@article{37828,
  abstract     = {{<jats:sec><jats:title>Introduction</jats:title><jats:p>Nursing staff is burdened by high workload and stress. Furthermore, heavy lifting, as well as transferring nursing home residents, cause lumbar tissue damage and back pain. Exercise intervention studies to reduce work-related problems are rare and the evidence for efficacy of studies among nurses is limited. Studies including targeted analysis of requirements are necessary to generate effective recommendations and tailored interventions for health promotion programmes. The purpose of this multicentred intervention study is to identify work-related problems, to implement health promotion programmes and to evaluate their effectiveness.</jats:p></jats:sec><jats:sec><jats:title>Methods and analysis</jats:title><jats:p>A randomised controlled trial will be conducted, including a total of 48 nursing home facilities in eight regions of Germany with an estimated sample size of 700 nurses. Standardised ergonomics and posture training (10 weeks, once a week for 20–30 min) and subsequently, back-fitness training (12 weeks, once a week for 45–60 min) will be administered. Following the implementation of standardised health promotion programmes, further demand-oriented interventions can be implemented. The perceived exposure to work-related demands, work-related pain in different parts of the body, health-related quality of life, perceived stress, work-related patterns of behaviour and experience, presentism behaviour, work environment as well as general needs and barriers to health promotion, will be assessed at baseline (pre-test), at 10 weeks (post-test, after ergonomics training), at 22 weeks (post-test, after back-fitness training) and at 34 weeks of the programme (follow-up).</jats:p></jats:sec><jats:sec><jats:title>Ethics and dissemination</jats:title><jats:p>The study was reviewed and approved by the local ethics committee of the University of Hamburg (AZ: 2018_168). The results of the study will be published in open-access and international journals. Furthermore, the results will be presented in the participating nursing homes and at national and international conferences.</jats:p></jats:sec><jats:sec><jats:title>Trial registration number</jats:title><jats:p>DRKS.de (DRKS00015241).</jats:p></jats:sec>}},
  author       = {{Otto, Ann-Kathrin and Pietschmann, Juliane and Appelles, Luisa-Marie and Bebenek, Michael and Bischoff, Laura L and Hildebrand, Claudia and Johnen, Bettina and Jöllenbeck, Thomas and Kemmler, Wolfgang and Klotzbier, Thomas and Korbus, Heide and Rudisch, Julian and Schott, Nadja and Schoene, Daniel and Voelcker-Rehage, Claudia and Vogel, Oliver and Vogt, Lutz and Weigelt, Matthias and Wilke, Jan and Zwingmann, Katharina and Wollesen, Bettina}},
  issn         = {{2044-6055}},
  journal      = {{BMJ Open}},
  keywords     = {{General Medicine}},
  number       = {{10}},
  publisher    = {{BMJ}},
  title        = {{{Physical activity and health promotion for nursing staff in elderly care: a study protocol for a randomised controlled trial}}},
  doi          = {{10.1136/bmjopen-2020-038202}},
  volume       = {{10}},
  year         = {{2020}},
}

@article{41079,
  author       = {{Schroeter-Wittke, Harald and Kirsner, Inge}},
  issn         = {{0079-4961}},
  journal      = {{Predigtstudien III/1}},
  pages        = {{72--79}},
  publisher    = {{Kreuz-Verlag}},
  title        = {{{1. Sonntag nach Weihnachten 27.12.2020. Lukas 2,(22-24)25-38(39-40): Missionarische Spiritualität }}},
  year         = {{2020}},
}

@book{41144,
  editor       = {{Wagenknecht, Inga and Bietz, I. and Kramer, A. and Müller, S. and Stibane, F.}},
  publisher    = {{Stadt Gießen}},
  title        = {{{Kommunale Planung für Senior*innen bis 2025. Fortschreibung des Altenhilfeplans aus dem Jahr 2013}}},
  year         = {{2020}},
}

@article{21420,
  author       = {{Mair, Christina and Scheffler, Wolfram and Senger, Isabell and Sureth-Sloane, Caren}},
  journal      = {{Steuer und Wirtschaft}},
  number       = {{4}},
  pages        = {{317--329}},
  title        = {{{Auswirkungen der digitalen Flexibilisierung des Fertigungsortes auf die Verteilung der Besteuerungsrechte – Ergebnisse von Modellrechnungen zum 3D-Druck-Verfahren}}},
  volume       = {{97}},
  year         = {{2020}},
}

@article{40217,
  author       = {{Wagenknecht, Inga and Meier-Gräwe, Uta}},
  issn         = {{2196-8225}},
  journal      = {{Praxis der Kinderpsychologie und Kinderpsychiatrie}},
  keywords     = {{Electrical and Electronic Engineering, Atomic and Molecular Physics, and Optics}},
  number       = {{7}},
  pages        = {{643--665}},
  publisher    = {{Vandenhoeck & Ruprecht GmbH & Co, KG}},
  title        = {{{Psychische Auffälligkeiten bei Kindern und Jugendlichen, für die das Jugendamt in Anspruch genommen wurde}}},
  doi          = {{10.13109/prkk.2020.69.7.643}},
  volume       = {{69}},
  year         = {{2020}},
}

@article{30118,
  abstract     = {{<jats:title>Zusammenfassung</jats:title><jats:p>
          Einleitung Im Rahmen der Demenz vom Alzheimer-Typ (DAT) zeigt sich eine gestörte neuronale Netzwerkorganisation, welche sich unter anderem auch im Default Mode Netzwerk (DMN) widerspiegelt. Multimodale Interventionen, wie zum Beispiel Golf, können einen positiven Einfluss auf die funktionelle Integrität der Netzwerke haben.</jats:p><jats:p>
          Methodik Im Rahmen einer Pilotstudie wurde der Einfluss des Erlernens der Sportart Golf bei sieben älteren Menschen (&gt; 60 Jahre) mit subjektiven Gedächtnisbeschwerden auf die funktionelle Konnektivität des DMN untersucht. Die Probanden haben 22 Wochen unter Anleitung eines professionellen Golftrainers dreimal wöchentlich je 60 min trainiert. Vor (Messzeitpunkt 0, MZP0) und nach der Intervention (Messzeitpunkt 1, MZP1) wurde eine Elektroenzephalografie (EEG)-Messung unter Ruhebedingungen (resting-state) durchgeführt. Die EEG-Daten wurden mit einem Magnetresonanztomographie-Template koregistriert. Die Konnektivitätsanalyse wurde in 15 Regionen des DMN durchgeführt und im Längsschnitt verglichen. Dabei wurden die Frequenzbänder beta (14–29 Hz) und theta (5–7 Hz) berücksichtigt.</jats:p><jats:p>
          Ergebnisse Nach der Intervention wurde eine höhere funktionelle Konnektivität im gesamten DMN bei 5 / 7 Teilnehmenden im beta Frequenzband bzw. bei 6 / 7 Probanden im theta Frequenzband zu MZP1 im Vergleich zu MZP0 gemessen. Im anterioren DMN war bei allen Probanden und Probandinnen die funktionelle Konnektivität im beta Frequenzband zu MZP1 im Vergleich zu MZP 0 höher, während sie im theta-Band bei 6 von 7 Teilnehmenden niedriger war. Im posterioren DMN war bei 6 von 7 (beta), bzw. 5 von 7 (theta) Probanden und Probandinnen die funktionelle Konnektivität zu MZP1 höher als zu MZP0. Spearman-Korrelationsanalysen zeigen zudem einen Zusammenhang zwischen der Teilnahmehäufigkeit und der prozentualen Veränderung der funktionellen Konnektivität im gesamten DMN des beta Frequenzbandes (r = 0,786, p = 0,036) und im anterioren DMN des theta Frequenzbandes (r = –0,821, p = 0,023).</jats:p><jats:p>
          Fazit Auf Basis der vorliegenden Daten lässt sich vermuten, dass das Erlernen der Sportart Golf einen Einfluss auf das DMN haben könnte. Die Ergebnisse bilden die Grundlage für die Planung einer Studie mit einer größeren Kohorte und randomisierten kontrollierten Design.</jats:p>}},
  author       = {{Ströhlein, Julia Kristin and Vieluf, Solveig and van den Bongard, Franziska and Gölz, Christian Johannes and Reinsberger, Claus}},
  issn         = {{1613-0863}},
  journal      = {{B&G Bewegungstherapie und Gesundheitssport}},
  number       = {{02}},
  pages        = {{65--72}},
  publisher    = {{Georg Thieme Verlag KG}},
  title        = {{{Golf spielen gegen die Vergesslichkeit: Effekte des Erlernens der Sportart auf das Default Mode Netzwerk des Gehirns}}},
  doi          = {{10.1055/a-1120-7002}},
  volume       = {{36}},
  year         = {{2020}},
}

@article{45126,
  abstract     = {{<jats:title>Abstract</jats:title><jats:sec>
                <jats:title>Purpose</jats:title>
                <jats:p>It has been reported that there is no correlation between anterior tibia translation (ATT) in passive and dynamic situations. Passive ATT (ATTp) may be different to dynamic ATT (ATTd) due to muscle activation patterns. This study aimed to investigate whether muscle activation during jumping can control ATT in healthy participants.</jats:p>
              </jats:sec><jats:sec>
                <jats:title>Methods</jats:title>
                <jats:p>ATTp of twenty-one healthy participants was measured using a KT-1000 arthrometer. All participants performed single leg hops for distance during which ATTd, knee flexion angles and knee flexion moments were measured using a 3D motion capture system. During both tests, sEMG signals were recorded.</jats:p>
              </jats:sec><jats:sec>
                <jats:title>Results</jats:title>
                <jats:p>A negative correlation was found between ATTp and the maximal ATTd (r = − 0.47, <jats:italic>p</jats:italic> = 0.028). An N-Way ANOVA showed that larger semitendinosus activity was seen when ATTd was larger, while less biceps femoris activity and rectus femoris activity were seen. Moreover, larger knee extension moment, knee flexion angle and ground reaction force in the anterior-posterior direction were seen when ATTd was larger.</jats:p>
              </jats:sec><jats:sec>
                <jats:title>Conclusion</jats:title>
                <jats:p>Participants with more ATTp showed smaller ATTd during jump landing. Muscle activation did not contribute to reduce ATTd during impact of a jump-landing at the observed knee angles. However, subjects with large ATTp landed with less knee flexion and consequently showed less ATTd. The results of this study give information on how healthy people control knee laxity during jump-landing.</jats:p>
              </jats:sec><jats:sec>
                <jats:title>Level of evidence</jats:title>
                <jats:p>III</jats:p>
              </jats:sec>}},
  author       = {{Keizer, Michèle N. J. and Hijmans, Juha M. and Gokeler, Alli and Benjaminse, Anne and Otten, Egbert}},
  issn         = {{2197-1153}},
  journal      = {{Journal of Experimental Orthopaedics}},
  keywords     = {{Orthopedics and Sports Medicine}},
  number       = {{1}},
  publisher    = {{Springer Science and Business Media LLC}},
  title        = {{{Healthy subjects with lax knees use less knee flexion rather than muscle control to limit anterior tibia translation during landing}}},
  doi          = {{10.1186/s40634-020-00246-6}},
  volume       = {{7}},
  year         = {{2020}},
}

@book{45662,
  author       = {{Lutz, Katharina and Offergeld, Jana and Freymuth, Nina and Arp, Anna Liza}},
  title        = {{{Gemeinsam Forschung gestalten. Handreichung zu partizipativer Forschung}}},
  year         = {{2020}},
}

@inproceedings{56490,
  author       = {{Hieke, Willi and Turhan, Anni-Yasmin}},
  booktitle    = {{Proceedings of the 6th Workshop on Formal and Cognitive Reasoning co-located with 43rd German Conference on Artificial Intelligence (KI-2020), Online / Bamberg, Germany, September 22, 2020}},
  editor       = {{Beierle, Christoph and Ragni, Marco and Stolzenburg, Frieder and Thimm, Matthias}},
  pages        = {{69–82}},
  publisher    = {{CEUR-WS.org}},
  title        = {{{Towards Model Transformation in Description Logics - Investigating the Case of Transductions}}},
  volume       = {{2680}},
  year         = {{2020}},
}

@article{63329,
  abstract     = {{<jats:title>Abstract</jats:title><jats:p>Recent experimental work has revealed that interstitial fluid flow can mobilize two types of tumor cell migration mechanisms. One is a chemotactic-driven mechanism where chemokine (chemical component) bounded to the extracellular matrix (ECM) is released and skewed in the flow direction. This leads to higher chemical concentrations downstream which the tumor cells can sense and migrate toward. The other is a mechanism where the flowing fluid imposes a stress on the tumor cells which triggers them to go in the upstream direction. Researchers have suggested that these two migration modes possibly can play a role in metastatic behavior, i.e., the process where tumor cells are able to break loose from the primary tumor and move to nearby lymphatic vessels. In Waldeland and Evje (J Biomech 81:22–35, 2018), a mathematical cell–fluid model was put forward based on a mixture theory formulation. It was demonstrated that the model was able to capture the main characteristics of the two competing migration mechanisms. The objective of the current work is to seek deeper insight into certain qualitative aspects of these competing mechanisms by means of mathematical methods. For that purpose, we propose a simpler version of the cell–fluid model mentioned above but such that the two competing migration mechanisms are retained. An initial cell distribution in a one-dimensional slab is exposed to a constant fluid flow from one end to the other, consistent with the experimental setup. Then, we explore by means of analytical estimates the long-time behavior of the two competing migration mechanisms for two different scenarios: (i) when the initial cell volume fraction is low and (ii) when the initial cell volume fraction is high. In particular, it is demonstrated in a strict mathematical sense that for a sufficiently low initial cell volume fraction, the downstream migration dominates in the sense that the solution converges to a downstream-dominated steady state as time elapses. On the other hand, with a sufficiently high initial cell volume fraction, the upstream migration mechanism is the stronger in the sense that the solution converges to an upstream-dominated steady state.
</jats:p>}},
  author       = {{Evje, Steinar and Winkler, Michael}},
  issn         = {{0938-8974}},
  journal      = {{Journal of Nonlinear Science}},
  number       = {{4}},
  pages        = {{1809--1847}},
  publisher    = {{Springer Science and Business Media LLC}},
  title        = {{{Mathematical Analysis of Two Competing Cancer Cell Migration Mechanisms Driven by Interstitial Fluid Flow}}},
  doi          = {{10.1007/s00332-020-09625-w}},
  volume       = {{30}},
  year         = {{2020}},
}

@inproceedings{25617,
  author       = {{Schöppner, Volker and Sporkmann, F.}},
  booktitle    = {{35th International Conference of the Polymer Processing Society (PPS)}},
  location     = {{Cesme (Türkei)}},
  title        = {{{Analysis of the Characteristic Flow Areas for Erdmenger-Elements to Predict the Throughput-Pressure Behavior of Co-Rotating Twin Screw Extruders by Using 3D FEM Simulation}}},
  year         = {{2019}},
}

@misc{28364,
  author       = {{Gausemeier, Jürgen}},
  isbn         = {{978-3-947647-09-5}},
  publisher    = {{Verlagsschriftenreihe des Heinz Nixdorf Instituts, Paderborn}},
  title        = {{{Vorausschau und Technologieplanung. 15. Symposium für Vorausschau und Technologieplanung, Heinz Nixdorf Institut, 21. und 22. November 2019}}},
  volume       = {{390}},
  year         = {{2019}},
}

@inproceedings{24060,
  abstract     = {{In diesem Artikel stellen wir eine Methode zur nicht-invasiven dynamischen Speicher- und IO-Analyse mit QEMU für sicherheitskritische eingebettete Software für die RISC-V Befehlssatzarchitektur vor. Die Implementierung basiert auf einer Erweiterung des Tiny Code Generator (TCG) des quelloffenen CPU-Emulators QEMU um die dynamische Identifikation von Zugriffen auf Datenspeicher sowie auf an die CPU angeschlossene IO-Geräte. Wir demonstrieren die Funktionalität der Methode anhand eines Versuchsaufbaus, bei dem eine Schließsystemkontrolle mittels serieller UART-Schnittstelle an einen RISC-V-Prozessor angebunden ist. Dieses Szenario zeigt, dass ein unberechtigter Zugriff auf die UART-Schnittstelle frühzeitig aufgedeckt und ein Angriff auf eine Zugangskontrolle somit endeckt werden kann. }},
  author       = {{Adelt, Peer and Koppelmann, Bastian and Müller, Wolfgang and Scheytt, Christoph}},
  booktitle    = {{MBMV 2019-22.Workshop Methoden und Beschreibungssprachen zur Modellierung und Verifikation von Schaltungen und Systemen (MBMV 2019)}},
  isbn         = {{978-3-8007-4945-4}},
  title        = {{{Analyse sicherheitskritischer Software für RISC-V Prozessoren}}},
  year         = {{2019}},
}

@inproceedings{24502,
  abstract     = {{Liquid atomization is expected to be a key process in Flame Spray Pyrolysis, as it determines the primary droplet size and velocity distribution, which represent initial conditions for flame shape and temperature field. A well-defined manipulation of atomization may be achieved by variation of nozzle geometry, injection parameter or fluid properties. However, change of fluid properties, e.g. varying solvents or increasing the precursor concentration, also influences the final particle properties. In this work, the influence of precursor concentration on fluid properties, spray and particle formation in Flame Spray Pyrolysis is experimentally investigated. High-speed shadowgraphy and Phase-Doppler measurements are conducted in a semi-closed combustion chamber with a well-defined burner geometry (SpraySyn burner) that is based on a coaxial atomization principle. By adding precursor to the flammable solvent, resulting spray characteristics, flame shape and appearance are changed in color, shape and mean droplet size distribution. Compared to resulting mean droplet sizes of pure solvent mixtures (D32, 22 μm), mean droplet sizes in the center of the precursor flame at 30 mm above the burner are generally smaller (D32, 18 μm). Persisting high share of small droplets in the droplet size distribution are presented, that presumably origin from an accumulation of metal organic precursor at the droplet surface during combustion, that acts as a diffusive barrier for high volatility solvent and thus reduces droplet evaporation. Sufficiently high above the nozzle exit, increasing the precursor concentration does not affect the radial distribution of mean droplet sizes but leads to increased mean particle sizes. More precursor presumably leads to higher concentrations of prime particles in the flame, thus probability of particle collusion and agglomeration. High-speed imaging at nozzle exit revealed random fluctuations of initial jet diameter, paired with jet axis shifting around 1000 Hz. These superposed fluctuations determine the initial conditions for atomization, induce pulsations in the flame and thus initiate the entire chain of the particle synthesis process.}},
  author       = {{Bieber, M. and Tischendorf, R. and Reddemann, M. and Schmid, H.-J. and Kneer, R.}},
  keywords     = {{FSP, nanoparticle synthesis, in situ measurements}},
  location     = {{Paris}},
  publisher    = {{ILASS (European Conference on Liquid Atomization and Spray Systems)}},
  title        = {{{Influence of precursor concentration on spray and particle formation in flame spray pyrolysis}}},
  year         = {{2019}},
}

@article{27003,
  author       = {{Perrar, Ines and Schmitting, Sarah and Della Corte, Karen W. and Buyken, Anette and Alexy, Ute}},
  issn         = {{1436-6207}},
  journal      = {{European Journal of Nutrition}},
  pages        = {{1043--1054}},
  title        = {{{Age and time trends in sugar intake among children and adolescents: results from the DONALD study}}},
  doi          = {{10.1007/s00394-019-01965-y}},
  year         = {{2019}},
}

@article{27004,
  author       = {{Wong, Tommy H. T. and Buyken, Anette and Brand-Miller, Jennie C. and Louie, Jimmy Chun Yu}},
  issn         = {{1436-6207}},
  journal      = {{European Journal of Nutrition}},
  pages        = {{2357--2367}},
  title        = {{{Is there a soft drink vs. alcohol seesaw? A cross-sectional analysis of dietary data in the Australian Health Survey 2011–12}}},
  doi          = {{10.1007/s00394-019-02084-4}},
  year         = {{2019}},
}

@article{27005,
  abstract     = {{<jats:title>ABSTRACT</jats:title>
               <jats:sec>
                  <jats:title>Background</jats:title>
                  <jats:p>There is controversy on the relevance of dietary sugar intake for cardiometabolic health.</jats:p>
               </jats:sec>
               <jats:sec>
                  <jats:title>Objective</jats:title>
                  <jats:p>The aim of this network meta-analysis (NMA) was to assess how isocaloric substitutions of dietary sugar with other carbohydrates affect cardiometabolic risk factors, comparing different intervention studies.</jats:p>
               </jats:sec>
               <jats:sec>
                  <jats:title>Methods</jats:title>
                  <jats:p>We included randomized controlled trials (RCTs) investigating the isocaloric effect of substituting dietary sugars (fructose, glucose, sucrose) with other sugars or starch on cardiometabolic risk markers, including LDL cholesterol, triacylglycerol (TG), fasting glucose (FG), glycated hemoglobin (HbA1c), insulin resistance (HOMA-IR), uric acid, C-reactive protein (CRP), alanine transaminase (ALT), aspartate transaminase (AST), and liver fat content. To identify the most beneficial intervention for each outcome, random-effects NMA was conducted by calculating pooled mean differences (MDs) with 95% CIs, and by ranking the surface under the cumulative ranking curves (SUCRAs). The certainty of evidence was evaluated using the Confidence In Network Meta-Analysis tool.</jats:p>
               </jats:sec>
               <jats:sec>
                  <jats:title>Results</jats:title>
                  <jats:p>Thirty-eight RCTs, including 1383 participants, were identified. A reduction in LDL-cholesterol concentrations was shown for the exchange of sucrose with starch (MD: −0.23 mmol/L; 95% CI: −0.38, −0.07 mmol/L) or fructose with starch (MD: −0.22 mmol/L; 95% CI: −0.39, −0.05 mmol/L; SUCRAstarch: 98%). FG concentrations were also lower for the exchange of sucrose with starch (MD: −0.14 mmol/L; 95% CI: −0.29, 0.01 mmol/L; SUCRAstarch: 91%). Replacing fructose with an equivalent energy amount of glucose reduced HOMA-IR (MD: −0.36; 95% CI: −0.71, −0.02; SUCRAglucose: 74%) and uric acid (MD: −23.77 µmol/L; 95% CI: −44.21, −3.32 µmol/L; SUCRAglucose: 93%). The certainty of evidence was rated very low to moderate. No significant effects were observed for TG, HbA1c, CRP, ALT, and AST.</jats:p>
               </jats:sec>
               <jats:sec>
                  <jats:title>Conclusions</jats:title>
                  <jats:p>Our findings indicate that substitution of sucrose and fructose with starch yielded lower LDL cholesterol. Insulin resistance and uric acid concentrations were beneficially affected by replacement of fructose with glucose. Our findings are limited by the very low to moderate certainty of evidence. This review was registered at www.crd.york.ac.uk/prospero as CRD42018080297.</jats:p>
               </jats:sec>}},
  author       = {{Schwingshackl, Lukas and Neuenschwander, Manuela and Hoffmann, Georg and Buyken, Anette and Schlesinger, Sabrina}},
  issn         = {{0002-9165}},
  journal      = {{The American Journal of Clinical Nutrition}},
  title        = {{{Dietary sugars and cardiometabolic risk factors: a network meta-analysis on isocaloric substitution interventions}}},
  doi          = {{10.1093/ajcn/nqz273}},
  year         = {{2019}},
}

@article{27006,
  abstract     = {{<jats:p>Trend analyses suggest that free sugar (FS) intake—while still exceeding 10%E—has decreased among German children and adolescents since 2005, yet that intakes may shift from sugars naturally occurring in foods to added sugars as children age. Thus, we analysed time and age trends in FS intake (%E) from food groups among 3–18 year-olds (1985–2016) using 10,761 3-day dietary records from 1312 DONALD participants (660 boys, 652 girls) by use of polynomial mixed-effects regression models. Among girls, FS from sugar &amp; sweets decreased from 1985 to 2016 (linear trend p &lt; 0.0001), but not among boys (p &gt; 0.05). In the total sample, FS intake from juices increased until 2000 and decreased since 2005 (linear, quadratic trend p &lt; 0.0001). FS from sugar sweetened beverages (SSB) decreased non-linearly from 1985 to 2016 (girls: linear, quadratic, cubic trend p &lt; 0.0001; boys: linear, quadratic, cubic trend p &lt; 0.02). Younger children consumed more FS from juices than older ones, who had a higher FS intake from SSB. FS intake from sugar &amp; sweets increased until early adolescence and decreased afterwards. Since sugar &amp; sweets represent the main source of FS intake and the source with the least pronounced decline in intake, public health measures should focus on these products.</jats:p>}},
  author       = {{Perrar, Ines and Schadow, Alena M. and Schmitting, Sarah and Buyken, Anette and Alexy, Ute}},
  issn         = {{2072-6643}},
  journal      = {{Nutrients}},
  title        = {{{Time and Age Trends in Free Sugar Intake from Food Groups among Children and Adolescents between 1985 and 2016}}},
  doi          = {{10.3390/nu12010020}},
  year         = {{2019}},
}

@article{27023,
  abstract     = {{<jats:title>Abstract</jats:title>
               <jats:sec>
                  <jats:title>Background</jats:title>
                  <jats:p>Blood immunoreactive biomarkers, such as C-reactive protein (CRP), and metabolic abnormalities have been associated with schizophrenia. Studies comprehensively and bidirectionally probing possible causal links between such blood constituents and liability to schizophrenia are lacking.</jats:p>
               </jats:sec>
               <jats:sec>
                  <jats:title>Methods</jats:title>
                  <jats:p>To disentangle putative causal links between CRP blood levels and schizophrenia in both directions, we conducted multiple univariable Mendelian-randomization (MR) analyses, ranging from fixed-effect to inverse variance-weighted (IVW), weighted-median, MR Egger and generalized summary-data-based Mendelian-randomization (GSMR) models. To prioritize metabolic risk factors for schizophrenia, a novel multivariable approach was applied: multivariable Mendelian-randomization–Bayesian model averaging (MR-BMA).</jats:p>
               </jats:sec>
               <jats:sec>
                  <jats:title>Results</jats:title>
                  <jats:p>All forward univariable MR analyses consistently showed that CRP has a protective effect on schizophrenia, whereas reverse MR analyses consistently suggested absent causal effects of schizophrenia liability on CRP blood levels. Using MR-BMA, as the top protective factors for schizophrenia we prioritized leucine and as the prime risk-factor triglycerides in medium very-low-density lipoprotein (VLDL). The five best-performing MR-BMA models provided one additional risk factor: triglycerides in large VLDL; and two additional protective factors: citrate and lactate.</jats:p>
               </jats:sec>
               <jats:sec>
                  <jats:title>Conclusions</jats:title>
                  <jats:p>Our results add to a growing body of literature hinting at metabolic changes—in particular of triglycerides—independently of medication status in schizophrenia. We also highlight the absent effects of genetic liability to schizophrenia on CRP levels.</jats:p>
               </jats:sec>}},
  author       = {{Lin, Bochao D and Alkema, Anne and Peters, Triinu and Zinkstok, Janneke and Libuda, Lars and Hebebrand, Johannes and Antel, Jochen and Hinney, Anke and Cahn, Wiepke and Adan, Roger and Luykx, Jurjen J}},
  issn         = {{0300-5771}},
  journal      = {{International Journal of Epidemiology}},
  pages        = {{1505--1514}},
  title        = {{{Assessing causal links between metabolic traits, inflammation and schizophrenia: a univariable and multivariable, bidirectional Mendelian-randomization study}}},
  doi          = {{10.1093/ije/dyz176}},
  year         = {{2019}},
}

@article{27024,
  author       = {{Kalhoff, Hermann and Mesch, Christina M. and Stimming, Madlen and Israel, Andreas and Spitzer, Christoph and Beganovic, Latifa and Perez, Rocio Estella and Koletzko, Berthold and Warschburger, Petra and Kersting, Mathilde and Libuda, Lars}},
  issn         = {{0954-3007}},
  journal      = {{European Journal of Clinical Nutrition}},
  pages        = {{682--690}},
  title        = {{{Effects of LC-PUFA supply via complementary food on infant development—a food based intervention (RCT) embedded in a total diet concept}}},
  doi          = {{10.1038/s41430-019-0491-0}},
  year         = {{2019}},
}

