[{"department":[{"_id":"35"},{"_id":"22"}],"user_id":"1112","_id":"54950","language":[{"iso":"eng"}],"publication":"The Journal of Physiology","type":"journal_article","status":"public","abstract":[{"text":"The mechanisms by which proteases activate the epithelial sodium channel (ENaC) are not yet fully understood. We investigated the effect of extracellular proteases on rat ENaC heterologously expressed in Xenopus laevis oocytes. Application of trypsin increased ENaC whole-oocyte currents by about 8-fold without a concomitant increase in channel surface expression. The stimulatory effect of trypsin was preserved in oocytes expressing alphagamma-ENaC, but was abolished in oocytes expressing alphabeta-ENaC. Thus, the gamma-subunit appears to be essential for channel activation by extracellular proteases. Site-directed mutagenesis of a putative prostasin cleavage site in the extracellular loop of the gamma-subunit revealed that mutating the 181Lys residue to alanine (gammaK181A) increases ENaC baseline whole-oocyte currents, decreases channel surface expression, and largely reduces the stimulatory effect of extracellular proteases (trypsin, chymotrypsin and human neutrophil elastase). In single-channel recordings from outside-out patches we demonstrated that the gammaK181A mutation essentially abolishes the activation of near-silent channels by trypsin, while a stimulatory effect of trypsin on channel gating is preserved. This apparent dual effect of trypsin on channel gating and on the recruitment of near-silent channels was confirmed by experiments using the beta518C mutant ENaC which can be converted to a channel with an open probability of nearly one by exposure to a sulfhydryl reagent. Interestingly, the gammaK181A mutation results in the spontaneous appearance of a 67 kDa fragment of the gamma-subunit in the plasma membrane which can be prevented by a furin inhibitor and also occurs after channel activation by extracellular trypsin. This suggests that the mutation promotes channel cleavage and activation by endogenous proteases. This would lower the pool of near-silent channels and explain the constitutive activation and reduced responsiveness of the mutant channel to extracellular proteases. We conclude that the mutated site (K181A) affects a region in the gamma-subunit of ENaC that is functionally important for the activation of near-silent channels by extracellular proteases.","lang":"eng"}],"volume":586,"author":[{"full_name":"Diakov, Alexei","last_name":"Diakov","first_name":"Alexei"},{"first_name":"Katarzyna","full_name":"Bera, Katarzyna","last_name":"Bera"},{"first_name":"Marianna","last_name":"Mokrushina","full_name":"Mokrushina, Marianna"},{"first_name":"Bettina","orcid":"0000-0001-5351-1785","last_name":"Krueger","full_name":"Krueger, Bettina","id":"49428"},{"first_name":"Christoph","full_name":"Korbmacher, Christoph","last_name":"Korbmacher"}],"date_created":"2024-06-30T14:02:04Z","publisher":"Wiley","date_updated":"2024-07-11T05:13:55Z","doi":"10.1113/jphysiol.2008.154435","title":"Cleavage in the γ-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels","issue":"19","page":"4587–4608","intvolume":"       586","citation":{"apa":"Diakov, A., Bera, K., Mokrushina, M., Krueger, B., &#38; Korbmacher, C. (2008). Cleavage in the γ-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels. <i>The Journal of Physiology</i>, <i>586</i>(19), 4587–4608. <a href=\"https://doi.org/10.1113/jphysiol.2008.154435\">https://doi.org/10.1113/jphysiol.2008.154435</a>","short":"A. Diakov, K. Bera, M. Mokrushina, B. Krueger, C. Korbmacher, The Journal of Physiology 586 (2008) 4587–4608.","mla":"Diakov, Alexei, et al. “Cleavage in the γ-Subunit of the Epithelial Sodium Channel (ENaC) Plays an Important Role in the Proteolytic Activation of near-Silent Channels.” <i>The Journal of Physiology</i>, vol. 586, no. 19, Wiley, 2008, pp. 4587–4608, doi:<a href=\"https://doi.org/10.1113/jphysiol.2008.154435\">10.1113/jphysiol.2008.154435</a>.","bibtex":"@article{Diakov_Bera_Mokrushina_Krueger_Korbmacher_2008, title={Cleavage in the γ-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels}, volume={586}, DOI={<a href=\"https://doi.org/10.1113/jphysiol.2008.154435\">10.1113/jphysiol.2008.154435</a>}, number={19}, journal={The Journal of Physiology}, publisher={Wiley}, author={Diakov, Alexei and Bera, Katarzyna and Mokrushina, Marianna and Krueger, Bettina and Korbmacher, Christoph}, year={2008}, pages={4587–4608} }","ama":"Diakov A, Bera K, Mokrushina M, Krueger B, Korbmacher C. Cleavage in the γ-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels. <i>The Journal of Physiology</i>. 2008;586(19):4587–4608. doi:<a href=\"https://doi.org/10.1113/jphysiol.2008.154435\">10.1113/jphysiol.2008.154435</a>","ieee":"A. Diakov, K. Bera, M. Mokrushina, B. Krueger, and C. Korbmacher, “Cleavage in the γ-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels,” <i>The Journal of Physiology</i>, vol. 586, no. 19, pp. 4587–4608, 2008, doi: <a href=\"https://doi.org/10.1113/jphysiol.2008.154435\">10.1113/jphysiol.2008.154435</a>.","chicago":"Diakov, Alexei, Katarzyna Bera, Marianna Mokrushina, Bettina Krueger, and Christoph Korbmacher. “Cleavage in the γ-Subunit of the Epithelial Sodium Channel (ENaC) Plays an Important Role in the Proteolytic Activation of near-Silent Channels.” <i>The Journal of Physiology</i> 586, no. 19 (2008): 4587–4608. <a href=\"https://doi.org/10.1113/jphysiol.2008.154435\">https://doi.org/10.1113/jphysiol.2008.154435</a>."},"year":"2008"},{"project":[{"_id":"52","name":"Computing Resources Provided by the Paderborn Center for Parallel Computing"}],"_id":"13672","user_id":"16199","department":[{"_id":"15"},{"_id":"170"},{"_id":"295"},{"_id":"35"},{"_id":"230"},{"_id":"27"}],"article_number":"225003","language":[{"iso":"eng"}],"type":"journal_article","publication":"Journal of Physics: Condensed Matter","status":"public","date_updated":"2025-12-05T13:09:17Z","author":[{"last_name":"Hermann","full_name":"Hermann, A","first_name":"A"},{"first_name":"P","full_name":"Schwerdtfeger, P","last_name":"Schwerdtfeger"},{"full_name":"Schmidt, Wolf Gero","id":"468","orcid":"0000-0002-2717-5076","last_name":"Schmidt","first_name":"Wolf Gero"}],"date_created":"2019-10-09T09:34:43Z","volume":20,"title":"Theoretical study of the localization of excess electrons at the surface of ice","doi":"10.1088/0953-8984/20/22/225003","publication_status":"published","publication_identifier":{"issn":["0953-8984","1361-648X"]},"year":"2008","citation":{"apa":"Hermann, A., Schwerdtfeger, P., &#38; Schmidt, W. G. (2008). Theoretical study of the localization of excess electrons at the surface of ice. <i>Journal of Physics: Condensed Matter</i>, <i>20</i>, Article 225003. <a href=\"https://doi.org/10.1088/0953-8984/20/22/225003\">https://doi.org/10.1088/0953-8984/20/22/225003</a>","short":"A. Hermann, P. Schwerdtfeger, W.G. Schmidt, Journal of Physics: Condensed Matter 20 (2008).","mla":"Hermann, A., et al. “Theoretical Study of the Localization of Excess Electrons at the Surface of Ice.” <i>Journal of Physics: Condensed Matter</i>, vol. 20, 225003, 2008, doi:<a href=\"https://doi.org/10.1088/0953-8984/20/22/225003\">10.1088/0953-8984/20/22/225003</a>.","bibtex":"@article{Hermann_Schwerdtfeger_Schmidt_2008, title={Theoretical study of the localization of excess electrons at the surface of ice}, volume={20}, DOI={<a href=\"https://doi.org/10.1088/0953-8984/20/22/225003\">10.1088/0953-8984/20/22/225003</a>}, number={225003}, journal={Journal of Physics: Condensed Matter}, author={Hermann, A and Schwerdtfeger, P and Schmidt, Wolf Gero}, year={2008} }","ieee":"A. Hermann, P. Schwerdtfeger, and W. G. Schmidt, “Theoretical study of the localization of excess electrons at the surface of ice,” <i>Journal of Physics: Condensed Matter</i>, vol. 20, Art. no. 225003, 2008, doi: <a href=\"https://doi.org/10.1088/0953-8984/20/22/225003\">10.1088/0953-8984/20/22/225003</a>.","chicago":"Hermann, A, P Schwerdtfeger, and Wolf Gero Schmidt. “Theoretical Study of the Localization of Excess Electrons at the Surface of Ice.” <i>Journal of Physics: Condensed Matter</i> 20 (2008). <a href=\"https://doi.org/10.1088/0953-8984/20/22/225003\">https://doi.org/10.1088/0953-8984/20/22/225003</a>.","ama":"Hermann A, Schwerdtfeger P, Schmidt WG. Theoretical study of the localization of excess electrons at the surface of ice. <i>Journal of Physics: Condensed Matter</i>. 2008;20. doi:<a href=\"https://doi.org/10.1088/0953-8984/20/22/225003\">10.1088/0953-8984/20/22/225003</a>"},"intvolume":"        20"},{"title":"Involving the User in Semantic Search","doi":"10.1007/978-3-540-73345-4\\_58","date_updated":"2022-01-06T06:57:02Z","publisher":"Springer","date_created":"2021-10-04T21:54:26Z","author":[{"first_name":"Axel-Cyrille","last_name":"Ngonga Ngomo","full_name":"Ngonga Ngomo, Axel-Cyrille","id":"65716"},{"last_name":"Schumacher","full_name":"Schumacher, Frank","first_name":"Frank"}],"volume":4557,"year":"2007","citation":{"chicago":"Ngonga Ngomo, Axel-Cyrille, and Frank Schumacher. “Involving the User in Semantic Search.” In <i>Human Interface and the Management of Information. Methods, Techniques and Tools in Information Design, Symposium on Human Interface 2007, Held as Part of {HCI} International 2007, Beijing, China, July 22-27, 2007, Proceedings Part {I}</i>, edited by Michael J. Smith and Gavriel Salvendy, 4557:507–16. Lecture Notes in Computer Science. Springer, 2007. <a href=\"https://doi.org/10.1007/978-3-540-73345-4\\_58\">https://doi.org/10.1007/978-3-540-73345-4\\_58</a>.","ieee":"A.-C. Ngonga Ngomo and F. Schumacher, “Involving the User in Semantic Search,” in <i>Human Interface and the Management of Information. Methods, Techniques and Tools in Information Design, Symposium on Human Interface 2007, Held as Part of {HCI} International 2007, Beijing, China, July 22-27, 2007, Proceedings Part {I}</i>, 2007, vol. 4557, pp. 507–516, doi: <a href=\"https://doi.org/10.1007/978-3-540-73345-4\\_58\">10.1007/978-3-540-73345-4\\_58</a>.","ama":"Ngonga Ngomo A-C, Schumacher F. Involving the User in Semantic Search. In: J. Smith M, Salvendy G, eds. <i>Human Interface and the Management of Information. Methods, Techniques and Tools in Information Design, Symposium on Human Interface 2007, Held as Part of {HCI} International 2007, Beijing, China, July 22-27, 2007, Proceedings Part {I}</i>. Vol 4557. Lecture Notes in Computer Science. Springer; 2007:507-516. doi:<a href=\"https://doi.org/10.1007/978-3-540-73345-4\\_58\">10.1007/978-3-540-73345-4\\_58</a>","apa":"Ngonga Ngomo, A.-C., &#38; Schumacher, F. (2007). Involving the User in Semantic Search. In M. J. Smith &#38; G. Salvendy (Eds.), <i>Human Interface and the Management of Information. Methods, Techniques and Tools in Information Design, Symposium on Human Interface 2007, Held as Part of {HCI} International 2007, Beijing, China, July 22-27, 2007, Proceedings Part {I}</i> (Vol. 4557, pp. 507–516). Springer. <a href=\"https://doi.org/10.1007/978-3-540-73345-4\\_58\">https://doi.org/10.1007/978-3-540-73345-4\\_58</a>","bibtex":"@inproceedings{Ngonga Ngomo_Schumacher_2007, series={Lecture Notes in Computer Science}, title={Involving the User in Semantic Search}, volume={4557}, DOI={<a href=\"https://doi.org/10.1007/978-3-540-73345-4\\_58\">10.1007/978-3-540-73345-4\\_58</a>}, booktitle={Human Interface and the Management of Information. Methods, Techniques and Tools in Information Design, Symposium on Human Interface 2007, Held as Part of {HCI} International 2007, Beijing, China, July 22-27, 2007, Proceedings Part {I}}, publisher={Springer}, author={Ngonga Ngomo, Axel-Cyrille and Schumacher, Frank}, editor={J. Smith, Michael and Salvendy, Gavriel}, year={2007}, pages={507–516}, collection={Lecture Notes in Computer Science} }","mla":"Ngonga Ngomo, Axel-Cyrille, and Frank Schumacher. “Involving the User in Semantic Search.” <i>Human Interface and the Management of Information. Methods, Techniques and Tools in Information Design, Symposium on Human Interface 2007, Held as Part of {HCI} International 2007, Beijing, China, July 22-27, 2007, Proceedings Part {I}</i>, edited by Michael J. Smith and Gavriel Salvendy, vol. 4557, Springer, 2007, pp. 507–16, doi:<a href=\"https://doi.org/10.1007/978-3-540-73345-4\\_58\">10.1007/978-3-540-73345-4\\_58</a>.","short":"A.-C. Ngonga Ngomo, F. Schumacher, in: M. J. Smith, G. Salvendy (Eds.), Human Interface and the Management of Information. Methods, Techniques and Tools in Information Design, Symposium on Human Interface 2007, Held as Part of {HCI} International 2007, Beijing, China, July 22-27, 2007, Proceedings Part {I}, Springer, 2007, pp. 507–516."},"page":"507-516","intvolume":"      4557","language":[{"iso":"eng"}],"_id":"25395","user_id":"15526","series_title":"Lecture Notes in Computer Science","editor":[{"last_name":"J. Smith","full_name":"J. Smith, Michael","first_name":"Michael"},{"first_name":"Gavriel","full_name":"Salvendy, Gavriel","last_name":"Salvendy"}],"status":"public","type":"conference","publication":"Human Interface and the Management of Information. Methods, Techniques and Tools in Information Design, Symposium on Human Interface 2007, Held as Part of {HCI} International 2007, Beijing, China, July 22-27, 2007, Proceedings Part {I}"},{"status":"public","type":"journal_article","_id":"25934","department":[{"_id":"17"},{"_id":"22"},{"_id":"571"}],"user_id":"61597","intvolume":"        85","page":"1626-1633","citation":{"ama":"Günther A, Buyken A, Kroke A. Protein intake during the period of complementary feeding and early childhood and the association with body mass index and percentage body fat at 7 y of age. <i>Am J Clin Nutr</i>. 2007;85(6):1626-1633. doi:<a href=\"https://doi.org/10.1093/ajcn/85.6.1626\">10.1093/ajcn/85.6.1626</a>","ieee":"A. Günther, A. Buyken, and A. Kroke, “Protein intake during the period of complementary feeding and early childhood and the association with body mass index and percentage body fat at 7 y of age.,” <i>Am J Clin Nutr</i>, vol. 85, no. 6, pp. 1626–1633, 2007, doi: <a href=\"https://doi.org/10.1093/ajcn/85.6.1626\">10.1093/ajcn/85.6.1626</a>.","chicago":"Günther, AL, Anette Buyken, and A Kroke. “Protein Intake during the Period of Complementary Feeding and Early Childhood and the Association with Body Mass Index and Percentage Body Fat at 7 y of Age.” <i>Am J Clin Nutr</i> 85, no. 6 (2007): 1626–33. <a href=\"https://doi.org/10.1093/ajcn/85.6.1626\">https://doi.org/10.1093/ajcn/85.6.1626</a>.","apa":"Günther, A., Buyken, A., &#38; Kroke, A. (2007). Protein intake during the period of complementary feeding and early childhood and the association with body mass index and percentage body fat at 7 y of age. <i>Am J Clin Nutr</i>, <i>85</i>(6), 1626–1633. <a href=\"https://doi.org/10.1093/ajcn/85.6.1626\">https://doi.org/10.1093/ajcn/85.6.1626</a>","mla":"Günther, AL, et al. “Protein Intake during the Period of Complementary Feeding and Early Childhood and the Association with Body Mass Index and Percentage Body Fat at 7 y of Age.” <i>Am J Clin Nutr</i>, vol. 85, no. 6, 2007, pp. 1626–33, doi:<a href=\"https://doi.org/10.1093/ajcn/85.6.1626\">10.1093/ajcn/85.6.1626</a>.","bibtex":"@article{Günther_Buyken_Kroke_2007, title={Protein intake during the period of complementary feeding and early childhood and the association with body mass index and percentage body fat at 7 y of age.}, volume={85}, DOI={<a href=\"https://doi.org/10.1093/ajcn/85.6.1626\">10.1093/ajcn/85.6.1626</a>}, number={6}, journal={Am J Clin Nutr}, author={Günther, AL and Buyken, Anette and Kroke, A}, year={2007}, pages={1626–1633} }","short":"A. Günther, A. Buyken, A. Kroke, Am J Clin Nutr 85 (2007) 1626–1633."},"publication_identifier":{"issn":["0002-9165","1938-3207"]},"pmid":"1","doi":"10.1093/ajcn/85.6.1626","date_updated":"2022-01-06T06:57:14Z","volume":85,"author":[{"first_name":"AL","full_name":"Günther, AL","last_name":"Günther"},{"full_name":"Buyken, Anette","id":"65985","last_name":"Buyken","first_name":"Anette"},{"full_name":"Kroke, A","last_name":"Kroke","first_name":"A"}],"publication":"Am J Clin Nutr","language":[{"iso":"eng"}],"external_id":{"pmid":["17556702"]},"year":"2007","issue":"6","title":"Protein intake during the period of complementary feeding and early childhood and the association with body mass index and percentage body fat at 7 y of age.","date_created":"2021-10-08T12:14:00Z"},{"issue":"4","year":"2007","date_created":"2021-10-08T12:15:48Z","title":"Breakfast glycemic index affects subsequent daily energy intake in free-living healthy children.","publication":"Am J Clin Nutr","external_id":{"pmid":["17921374"]},"language":[{"iso":"eng"}],"publication_identifier":{"issn":["0002-9165","1938-3207"]},"pmid":"1","intvolume":"        86","page":"980-987","citation":{"ama":"Buyken A, Trauner K, Günther A, Kroke A, Remer T. Breakfast glycemic index affects subsequent daily energy intake in free-living healthy children. <i>Am J Clin Nutr</i>. 2007;86(4):980-987. doi:<a href=\"https://doi.org/10.1093/ajcn/86.4.980\">10.1093/ajcn/86.4.980</a>","ieee":"A. Buyken, K. Trauner, A. Günther, A. Kroke, and T. Remer, “Breakfast glycemic index affects subsequent daily energy intake in free-living healthy children.,” <i>Am J Clin Nutr</i>, vol. 86, no. 4, pp. 980–987, 2007, doi: <a href=\"https://doi.org/10.1093/ajcn/86.4.980\">10.1093/ajcn/86.4.980</a>.","chicago":"Buyken, Anette, K Trauner, AL Günther, A Kroke, and T Remer. “Breakfast Glycemic Index Affects Subsequent Daily Energy Intake in Free-Living Healthy Children.” <i>Am J Clin Nutr</i> 86, no. 4 (2007): 980–87. <a href=\"https://doi.org/10.1093/ajcn/86.4.980\">https://doi.org/10.1093/ajcn/86.4.980</a>.","apa":"Buyken, A., Trauner, K., Günther, A., Kroke, A., &#38; Remer, T. (2007). Breakfast glycemic index affects subsequent daily energy intake in free-living healthy children. <i>Am J Clin Nutr</i>, <i>86</i>(4), 980–987. <a href=\"https://doi.org/10.1093/ajcn/86.4.980\">https://doi.org/10.1093/ajcn/86.4.980</a>","mla":"Buyken, Anette, et al. “Breakfast Glycemic Index Affects Subsequent Daily Energy Intake in Free-Living Healthy Children.” <i>Am J Clin Nutr</i>, vol. 86, no. 4, 2007, pp. 980–87, doi:<a href=\"https://doi.org/10.1093/ajcn/86.4.980\">10.1093/ajcn/86.4.980</a>.","bibtex":"@article{Buyken_Trauner_Günther_Kroke_Remer_2007, title={Breakfast glycemic index affects subsequent daily energy intake in free-living healthy children.}, volume={86}, DOI={<a href=\"https://doi.org/10.1093/ajcn/86.4.980\">10.1093/ajcn/86.4.980</a>}, number={4}, journal={Am J Clin Nutr}, author={Buyken, Anette and Trauner, K and Günther, AL and Kroke, A and Remer, T}, year={2007}, pages={980–987} }","short":"A. Buyken, K. Trauner, A. Günther, A. Kroke, T. Remer, Am J Clin Nutr 86 (2007) 980–987."},"volume":86,"author":[{"first_name":"Anette","id":"65985","full_name":"Buyken, Anette","last_name":"Buyken"},{"first_name":"K","full_name":"Trauner, K","last_name":"Trauner"},{"first_name":"AL","full_name":"Günther, AL","last_name":"Günther"},{"last_name":"Kroke","full_name":"Kroke, A","first_name":"A"},{"first_name":"T","full_name":"Remer, T","last_name":"Remer"}],"date_updated":"2022-01-06T06:57:14Z","doi":"10.1093/ajcn/86.4.980","type":"journal_article","status":"public","department":[{"_id":"17"},{"_id":"22"},{"_id":"571"}],"user_id":"61597","_id":"25935"},{"external_id":{"pmid":["18065589"]},"language":[{"iso":"eng"}],"publication":"Am J Clin Nutr","date_created":"2021-10-08T12:24:56Z","title":"How early dietary factors modify the effect of rapid weight gain in infancy on subsequent body-composition development in term children whose birth weight was appropriate for gestational age.","issue":"6","year":"2007","_id":"25936","user_id":"61597","department":[{"_id":"17"},{"_id":"22"},{"_id":"571"}],"type":"journal_article","status":"public","date_updated":"2022-01-06T06:57:14Z","author":[{"first_name":"N","last_name":"Karaolis-Danckert","full_name":"Karaolis-Danckert, N"},{"last_name":"Günther","full_name":"Günther, AL","first_name":"AL"},{"first_name":"A","full_name":"Kroke, A","last_name":"Kroke"},{"first_name":"C","last_name":"Hornberg","full_name":"Hornberg, C"},{"full_name":"Buyken, Anette","id":"65985","last_name":"Buyken","first_name":"Anette"}],"volume":86,"doi":"10.1093/ajcn/86.5.1700","publication_identifier":{"issn":["0002-9165","1938-3207"]},"pmid":"1","citation":{"apa":"Karaolis-Danckert, N., Günther, A., Kroke, A., Hornberg, C., &#38; Buyken, A. (2007). How early dietary factors modify the effect of rapid weight gain in infancy on subsequent body-composition development in term children whose birth weight was appropriate for gestational age. <i>Am J Clin Nutr</i>, <i>86</i>(6), 1700–1708. <a href=\"https://doi.org/10.1093/ajcn/86.5.1700\">https://doi.org/10.1093/ajcn/86.5.1700</a>","bibtex":"@article{Karaolis-Danckert_Günther_Kroke_Hornberg_Buyken_2007, title={How early dietary factors modify the effect of rapid weight gain in infancy on subsequent body-composition development in term children whose birth weight was appropriate for gestational age.}, volume={86}, DOI={<a href=\"https://doi.org/10.1093/ajcn/86.5.1700\">10.1093/ajcn/86.5.1700</a>}, number={6}, journal={Am J Clin Nutr}, author={Karaolis-Danckert, N and Günther, AL and Kroke, A and Hornberg, C and Buyken, Anette}, year={2007}, pages={1700–1708} }","short":"N. Karaolis-Danckert, A. Günther, A. Kroke, C. Hornberg, A. Buyken, Am J Clin Nutr 86 (2007) 1700–1708.","mla":"Karaolis-Danckert, N., et al. “How Early Dietary Factors Modify the Effect of Rapid Weight Gain in Infancy on Subsequent Body-Composition Development in Term Children Whose Birth Weight Was Appropriate for Gestational Age.” <i>Am J Clin Nutr</i>, vol. 86, no. 6, 2007, pp. 1700–08, doi:<a href=\"https://doi.org/10.1093/ajcn/86.5.1700\">10.1093/ajcn/86.5.1700</a>.","ieee":"N. Karaolis-Danckert, A. Günther, A. Kroke, C. Hornberg, and A. Buyken, “How early dietary factors modify the effect of rapid weight gain in infancy on subsequent body-composition development in term children whose birth weight was appropriate for gestational age.,” <i>Am J Clin Nutr</i>, vol. 86, no. 6, pp. 1700–1708, 2007, doi: <a href=\"https://doi.org/10.1093/ajcn/86.5.1700\">10.1093/ajcn/86.5.1700</a>.","chicago":"Karaolis-Danckert, N, AL Günther, A Kroke, C Hornberg, and Anette Buyken. “How Early Dietary Factors Modify the Effect of Rapid Weight Gain in Infancy on Subsequent Body-Composition Development in Term Children Whose Birth Weight Was Appropriate for Gestational Age.” <i>Am J Clin Nutr</i> 86, no. 6 (2007): 1700–1708. <a href=\"https://doi.org/10.1093/ajcn/86.5.1700\">https://doi.org/10.1093/ajcn/86.5.1700</a>.","ama":"Karaolis-Danckert N, Günther A, Kroke A, Hornberg C, Buyken A. How early dietary factors modify the effect of rapid weight gain in infancy on subsequent body-composition development in term children whose birth weight was appropriate for gestational age. <i>Am J Clin Nutr</i>. 2007;86(6):1700-1708. doi:<a href=\"https://doi.org/10.1093/ajcn/86.5.1700\">10.1093/ajcn/86.5.1700</a>"},"page":"1700-1708","intvolume":"        86"},{"publication":"Am J Clin Nutr","external_id":{"pmid":["18065597"]},"language":[{"iso":"eng"}],"issue":"6","year":"2007","date_created":"2021-10-08T12:30:04Z","title":"Early protein intake and later obesity risk: which protein sources at which time points throughout infancy and childhood are important for body mass index and body fat percentage at 7 y of age?","type":"journal_article","status":"public","_id":"25937","department":[{"_id":"17"},{"_id":"22"},{"_id":"571"}],"user_id":"61597","publication_identifier":{"issn":["0002-9165","1938-3207"]},"pmid":"1","page":"1765-1772","intvolume":"        86","citation":{"ama":"Günther A, Remer T, Kroke A, Buyken A. Early protein intake and later obesity risk: which protein sources at which time points throughout infancy and childhood are important for body mass index and body fat percentage at 7 y of age? <i>Am J Clin Nutr</i>. 2007;86(6):1765-1772. doi:<a href=\"https://doi.org/10.1093/ajcn/86.5.1765\">10.1093/ajcn/86.5.1765</a>","ieee":"A. Günther, T. Remer, A. Kroke, and A. Buyken, “Early protein intake and later obesity risk: which protein sources at which time points throughout infancy and childhood are important for body mass index and body fat percentage at 7 y of age?,” <i>Am J Clin Nutr</i>, vol. 86, no. 6, pp. 1765–1772, 2007, doi: <a href=\"https://doi.org/10.1093/ajcn/86.5.1765\">10.1093/ajcn/86.5.1765</a>.","chicago":"Günther, AL, T Remer, A Kroke, and Anette Buyken. “Early Protein Intake and Later Obesity Risk: Which Protein Sources at Which Time Points throughout Infancy and Childhood Are Important for Body Mass Index and Body Fat Percentage at 7 y of Age?” <i>Am J Clin Nutr</i> 86, no. 6 (2007): 1765–72. <a href=\"https://doi.org/10.1093/ajcn/86.5.1765\">https://doi.org/10.1093/ajcn/86.5.1765</a>.","apa":"Günther, A., Remer, T., Kroke, A., &#38; Buyken, A. (2007). Early protein intake and later obesity risk: which protein sources at which time points throughout infancy and childhood are important for body mass index and body fat percentage at 7 y of age? <i>Am J Clin Nutr</i>, <i>86</i>(6), 1765–1772. <a href=\"https://doi.org/10.1093/ajcn/86.5.1765\">https://doi.org/10.1093/ajcn/86.5.1765</a>","mla":"Günther, AL, et al. “Early Protein Intake and Later Obesity Risk: Which Protein Sources at Which Time Points throughout Infancy and Childhood Are Important for Body Mass Index and Body Fat Percentage at 7 y of Age?” <i>Am J Clin Nutr</i>, vol. 86, no. 6, 2007, pp. 1765–72, doi:<a href=\"https://doi.org/10.1093/ajcn/86.5.1765\">10.1093/ajcn/86.5.1765</a>.","bibtex":"@article{Günther_Remer_Kroke_Buyken_2007, title={Early protein intake and later obesity risk: which protein sources at which time points throughout infancy and childhood are important for body mass index and body fat percentage at 7 y of age?}, volume={86}, DOI={<a href=\"https://doi.org/10.1093/ajcn/86.5.1765\">10.1093/ajcn/86.5.1765</a>}, number={6}, journal={Am J Clin Nutr}, author={Günther, AL and Remer, T and Kroke, A and Buyken, Anette}, year={2007}, pages={1765–1772} }","short":"A. Günther, T. Remer, A. Kroke, A. Buyken, Am J Clin Nutr 86 (2007) 1765–1772."},"date_updated":"2022-01-06T06:57:14Z","volume":86,"author":[{"first_name":"AL","full_name":"Günther, AL","last_name":"Günther"},{"full_name":"Remer, T","last_name":"Remer","first_name":"T"},{"last_name":"Kroke","full_name":"Kroke, A","first_name":"A"},{"last_name":"Buyken","id":"65985","full_name":"Buyken, Anette","first_name":"Anette"}],"doi":"10.1093/ajcn/86.5.1765"},{"page":"1370-1379","citation":{"ieee":"L. Libuda <i>et al.</i>, “Pattern of beverage consumption and long-term association with body-weight status in German adolescents – results from the DONALD study,” <i>British Journal of Nutrition</i>, pp. 1370–1379, 2007, doi: <a href=\"https://doi.org/10.1017/s0007114507862362\">10.1017/s0007114507862362</a>.","chicago":"Libuda, Lars, Ute Alexy, Wolfgang Sichert-Hellert, Peter Stehle, Nadina Karaolis-Danckert, Anette Buyken, and Mathilde Kersting. “Pattern of Beverage Consumption and Long-Term Association with Body-Weight Status in German Adolescents – Results from the DONALD Study.” <i>British Journal of Nutrition</i>, 2007, 1370–79. <a href=\"https://doi.org/10.1017/s0007114507862362\">https://doi.org/10.1017/s0007114507862362</a>.","ama":"Libuda L, Alexy U, Sichert-Hellert W, et al. Pattern of beverage consumption and long-term association with body-weight status in German adolescents – results from the DONALD study. <i>British Journal of Nutrition</i>. Published online 2007:1370-1379. doi:<a href=\"https://doi.org/10.1017/s0007114507862362\">10.1017/s0007114507862362</a>","short":"L. Libuda, U. Alexy, W. Sichert-Hellert, P. Stehle, N. Karaolis-Danckert, A. Buyken, M. Kersting, British Journal of Nutrition (2007) 1370–1379.","mla":"Libuda, Lars, et al. “Pattern of Beverage Consumption and Long-Term Association with Body-Weight Status in German Adolescents – Results from the DONALD Study.” <i>British Journal of Nutrition</i>, 2007, pp. 1370–79, doi:<a href=\"https://doi.org/10.1017/s0007114507862362\">10.1017/s0007114507862362</a>.","bibtex":"@article{Libuda_Alexy_Sichert-Hellert_Stehle_Karaolis-Danckert_Buyken_Kersting_2007, title={Pattern of beverage consumption and long-term association with body-weight status in German adolescents – results from the DONALD study}, DOI={<a href=\"https://doi.org/10.1017/s0007114507862362\">10.1017/s0007114507862362</a>}, journal={British Journal of Nutrition}, author={Libuda, Lars and Alexy, Ute and Sichert-Hellert, Wolfgang and Stehle, Peter and Karaolis-Danckert, Nadina and Buyken, Anette and Kersting, Mathilde}, year={2007}, pages={1370–1379} }","apa":"Libuda, L., Alexy, U., Sichert-Hellert, W., Stehle, P., Karaolis-Danckert, N., Buyken, A., &#38; Kersting, M. (2007). Pattern of beverage consumption and long-term association with body-weight status in German adolescents – results from the DONALD study. <i>British Journal of Nutrition</i>, 1370–1379. <a href=\"https://doi.org/10.1017/s0007114507862362\">https://doi.org/10.1017/s0007114507862362</a>"},"year":"2007","publication_identifier":{"issn":["0007-1145","1475-2662"]},"publication_status":"published","doi":"10.1017/s0007114507862362","title":"Pattern of beverage consumption and long-term association with body-weight status in German adolescents – results from the DONALD study","author":[{"first_name":"Lars","full_name":"Libuda, Lars","id":"88682","last_name":"Libuda","orcid":"0000-0003-1603-3133"},{"last_name":"Alexy","full_name":"Alexy, Ute","first_name":"Ute"},{"last_name":"Sichert-Hellert","full_name":"Sichert-Hellert, Wolfgang","first_name":"Wolfgang"},{"full_name":"Stehle, Peter","last_name":"Stehle","first_name":"Peter"},{"first_name":"Nadina","full_name":"Karaolis-Danckert, Nadina","last_name":"Karaolis-Danckert"},{"id":"65985","full_name":"Buyken, Anette","last_name":"Buyken","first_name":"Anette"},{"first_name":"Mathilde","last_name":"Kersting","full_name":"Kersting, Mathilde"}],"date_created":"2021-11-03T20:20:28Z","date_updated":"2022-01-06T06:57:35Z","status":"public","abstract":[{"lang":"eng","text":"<jats:p>In the present study the relationship between the consumption of different beverage groups and body-weight status in 5 years of study participation in German adolescents was investigated. We used anthropometric and dietary data from 3 d weighed records of 244 subjects between 9 and 18 years of age participating in the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study. Only subjects with at least four out of six possible weighed dietary records were considered. A repeated-measures regression model (PROC MIXED) was used to analyse the effect of beverage consumption on body-weight status. BMI standard deviation scores (BMI-SDS) and body fat percentage (%BF) were chosen as the dependent variables. In boys, energetic beverage consumption was not associated with BMI-SDS or %BF, neither cross-sectionally nor prospectively. In girls, baseline consumption of energetic beverages did not predict baseline BMI-SDS, baseline %BF, or change in either variable over the study period. However, an increase in energetic beverage consumption over the study period was associated with an increase in BMI-SDS (+0.070 SDS/MJ increase in energetic beverage consumption; <jats:italic>P</jats:italic> = 0·01). Separate consideration of regular soft drinks and fruit juices revealed that, in girls, BMI-SDS increased with increased fruit juice consumption (+0·096 SDS/MJ increase in fruit juice consumption; <jats:italic>P</jats:italic> = 0·01), and to a lesser extent with regular soft drink consumption (+0·055 SDS/MJ increase in regular soft drink consumption; <jats:italic>P</jats:italic> = 0·08). In conclusion, these results suggest that an increase in energetic beverage consumption may result in weight gain, at least in adolescent girls.</jats:p>"}],"publication":"British Journal of Nutrition","type":"journal_article","language":[{"iso":"eng"}],"department":[{"_id":"35"},{"_id":"22"},{"_id":"395"}],"user_id":"49428","_id":"27138"},{"department":[{"_id":"35"},{"_id":"22"},{"_id":"395"}],"user_id":"49428","_id":"27588","language":[{"iso":"ger"}],"publication":"Monatsschriften Kinderheilkunde","type":"journal_article","status":"public","volume":155,"date_created":"2021-11-19T09:52:27Z","author":[{"orcid":"0000-0003-1603-3133","last_name":"Libuda","id":"88682","full_name":"Libuda, Lars","first_name":"Lars"},{"first_name":"U.","full_name":"Alexey, U.","last_name":"Alexey"}],"date_updated":"2022-01-06T06:57:42Z","title":"DONALD News: Zuckerhaltige Getränke und Übergewicht bei Kindern.","publication_status":"published","intvolume":"       155","page":"684","citation":{"ama":"Libuda L, Alexey U. DONALD News: Zuckerhaltige Getränke und Übergewicht bei Kindern. <i>Monatsschriften Kinderheilkunde</i>. 2007;155:684.","ieee":"L. Libuda and U. Alexey, “DONALD News: Zuckerhaltige Getränke und Übergewicht bei Kindern.,” <i>Monatsschriften Kinderheilkunde</i>, vol. 155, p. 684, 2007.","chicago":"Libuda, Lars, and U. Alexey. “DONALD News: Zuckerhaltige Getränke und Übergewicht bei Kindern.” <i>Monatsschriften Kinderheilkunde</i> 155 (2007): 684.","short":"L. Libuda, U. Alexey, Monatsschriften Kinderheilkunde 155 (2007) 684.","bibtex":"@article{Libuda_Alexey_2007, title={DONALD News: Zuckerhaltige Getränke und Übergewicht bei Kindern.}, volume={155}, journal={Monatsschriften Kinderheilkunde}, author={Libuda, Lars and Alexey, U.}, year={2007}, pages={684} }","mla":"Libuda, Lars, and U. Alexey. “DONALD News: Zuckerhaltige Getränke und Übergewicht bei Kindern.” <i>Monatsschriften Kinderheilkunde</i>, vol. 155, 2007, p. 684.","apa":"Libuda, L., &#38; Alexey, U. (2007). DONALD News: Zuckerhaltige Getränke und Übergewicht bei Kindern. <i>Monatsschriften Kinderheilkunde</i>, <i>155</i>, 684."},"year":"2007"},{"publication_identifier":{"issn":["0149-5992","1935-5548"]},"publication_status":"published","page":"2986-2986","citation":{"apa":"Buyken, A., &#38; Liese, A. D. (2007). Dietary Glycemic Index, Glycemic Load, Fiber, Simple Sugars, and Insulin Resistance: The Inter99 Study: Response to Lau et al. <i>Diabetes Care</i>, 2986–2986. <a href=\"https://doi.org/10.2337/diacare.28.12.2986\">https://doi.org/10.2337/diacare.28.12.2986</a>","mla":"Buyken, Anette, and A. D. Liese. “Dietary Glycemic Index, Glycemic Load, Fiber, Simple Sugars, and Insulin Resistance: The Inter99 Study: Response to Lau et Al.” <i>Diabetes Care</i>, 2007, pp. 2986–2986, doi:<a href=\"https://doi.org/10.2337/diacare.28.12.2986\">10.2337/diacare.28.12.2986</a>.","bibtex":"@article{Buyken_Liese_2007, title={Dietary Glycemic Index, Glycemic Load, Fiber, Simple Sugars, and Insulin Resistance: The Inter99 Study: Response to Lau et al.}, DOI={<a href=\"https://doi.org/10.2337/diacare.28.12.2986\">10.2337/diacare.28.12.2986</a>}, journal={Diabetes Care}, author={Buyken, Anette and Liese, A. D.}, year={2007}, pages={2986–2986} }","short":"A. Buyken, A.D. Liese, Diabetes Care (2007) 2986–2986.","ieee":"A. Buyken and A. D. Liese, “Dietary Glycemic Index, Glycemic Load, Fiber, Simple Sugars, and Insulin Resistance: The Inter99 Study: Response to Lau et al.,” <i>Diabetes Care</i>, pp. 2986–2986, 2007, doi: <a href=\"https://doi.org/10.2337/diacare.28.12.2986\">10.2337/diacare.28.12.2986</a>.","chicago":"Buyken, Anette, and A. D. Liese. “Dietary Glycemic Index, Glycemic Load, Fiber, Simple Sugars, and Insulin Resistance: The Inter99 Study: Response to Lau et Al.” <i>Diabetes Care</i>, 2007, 2986–2986. <a href=\"https://doi.org/10.2337/diacare.28.12.2986\">https://doi.org/10.2337/diacare.28.12.2986</a>.","ama":"Buyken A, Liese AD. Dietary Glycemic Index, Glycemic Load, Fiber, Simple Sugars, and Insulin Resistance: The Inter99 Study: Response to Lau et al. <i>Diabetes Care</i>. Published online 2007:2986-2986. doi:<a href=\"https://doi.org/10.2337/diacare.28.12.2986\">10.2337/diacare.28.12.2986</a>"},"year":"2007","date_created":"2021-11-23T12:46:02Z","author":[{"first_name":"Anette","last_name":"Buyken","id":"65985","full_name":"Buyken, Anette"},{"full_name":"Liese, A. D.","last_name":"Liese","first_name":"A. D."}],"date_updated":"2022-01-06T06:57:44Z","doi":"10.2337/diacare.28.12.2986","title":"Dietary Glycemic Index, Glycemic Load, Fiber, Simple Sugars, and Insulin Resistance: The Inter99 Study: Response to Lau et al.","publication":"Diabetes Care","type":"journal_article","status":"public","department":[{"_id":"17"},{"_id":"22"},{"_id":"571"}],"user_id":"61597","_id":"27710","language":[{"iso":"eng"}]},{"type":"journal_article","publication":"European Journal of Cardiovascular Prevention & Rehabilitation","status":"public","user_id":"61597","department":[{"_id":"17"},{"_id":"22"},{"_id":"571"}],"_id":"27789","language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"issn":["1741-8267"]},"citation":{"ama":"Buyken A, von Eckardstein A, Schulte H, Cullen P, Assmann G. Type 2 diabetes mellitus and risk of coronary heart disease: results of the 10-year follow-up of the PROCAM study. <i>European Journal of Cardiovascular Prevention &#38; Rehabilitation</i>. Published online 2007:230-236. doi:<a href=\"https://doi.org/10.1097/hjr.0b013e3280142037\">10.1097/hjr.0b013e3280142037</a>","ieee":"A. Buyken, A. von Eckardstein, H. Schulte, P. Cullen, and G. Assmann, “Type 2 diabetes mellitus and risk of coronary heart disease: results of the 10-year follow-up of the PROCAM study,” <i>European Journal of Cardiovascular Prevention &#38; Rehabilitation</i>, pp. 230–236, 2007, doi: <a href=\"https://doi.org/10.1097/hjr.0b013e3280142037\">10.1097/hjr.0b013e3280142037</a>.","chicago":"Buyken, Anette, Arnold von Eckardstein, Helmut Schulte, Paul Cullen, and Gerd Assmann. “Type 2 Diabetes Mellitus and Risk of Coronary Heart Disease: Results of the 10-Year Follow-up of the PROCAM Study.” <i>European Journal of Cardiovascular Prevention &#38; Rehabilitation</i>, 2007, 230–36. <a href=\"https://doi.org/10.1097/hjr.0b013e3280142037\">https://doi.org/10.1097/hjr.0b013e3280142037</a>.","bibtex":"@article{Buyken_von Eckardstein_Schulte_Cullen_Assmann_2007, title={Type 2 diabetes mellitus and risk of coronary heart disease: results of the 10-year follow-up of the PROCAM study}, DOI={<a href=\"https://doi.org/10.1097/hjr.0b013e3280142037\">10.1097/hjr.0b013e3280142037</a>}, journal={European Journal of Cardiovascular Prevention &#38; Rehabilitation}, author={Buyken, Anette and von Eckardstein, Arnold and Schulte, Helmut and Cullen, Paul and Assmann, Gerd}, year={2007}, pages={230–236} }","short":"A. Buyken, A. von Eckardstein, H. Schulte, P. Cullen, G. Assmann, European Journal of Cardiovascular Prevention &#38; Rehabilitation (2007) 230–236.","mla":"Buyken, Anette, et al. “Type 2 Diabetes Mellitus and Risk of Coronary Heart Disease: Results of the 10-Year Follow-up of the PROCAM Study.” <i>European Journal of Cardiovascular Prevention &#38; Rehabilitation</i>, 2007, pp. 230–36, doi:<a href=\"https://doi.org/10.1097/hjr.0b013e3280142037\">10.1097/hjr.0b013e3280142037</a>.","apa":"Buyken, A., von Eckardstein, A., Schulte, H., Cullen, P., &#38; Assmann, G. (2007). Type 2 diabetes mellitus and risk of coronary heart disease: results of the 10-year follow-up of the PROCAM study. <i>European Journal of Cardiovascular Prevention &#38; Rehabilitation</i>, 230–236. <a href=\"https://doi.org/10.1097/hjr.0b013e3280142037\">https://doi.org/10.1097/hjr.0b013e3280142037</a>"},"page":"230-236","year":"2007","date_created":"2021-11-25T11:57:36Z","author":[{"last_name":"Buyken","id":"65985","full_name":"Buyken, Anette","first_name":"Anette"},{"first_name":"Arnold","last_name":"von Eckardstein","full_name":"von Eckardstein, Arnold"},{"first_name":"Helmut","full_name":"Schulte, Helmut","last_name":"Schulte"},{"full_name":"Cullen, Paul","last_name":"Cullen","first_name":"Paul"},{"full_name":"Assmann, Gerd","last_name":"Assmann","first_name":"Gerd"}],"date_updated":"2022-01-06T06:57:45Z","doi":"10.1097/hjr.0b013e3280142037","title":"Type 2 diabetes mellitus and risk of coronary heart disease: results of the 10-year follow-up of the PROCAM study"},{"status":"public","publication":"Haushalt & Bildung","type":"journal_article","language":[{"iso":"eng"}],"_id":"27889","department":[{"_id":"35"},{"_id":"22"},{"_id":"396"}],"user_id":"49428","year":"2007","page":"35-46","intvolume":"        84","citation":{"short":"K. Schlegel-Matthies, Haushalt &#38; Bildung 84 (2007) 35–46.","mla":"Schlegel-Matthies, Kirsten. “Zum Umgang Mit Vielfalt Im Haushaltsbezogenen Unterricht.” <i>Haushalt &#38; Bildung</i>, vol. 84, no. 1, 2007, pp. 35–46.","bibtex":"@article{Schlegel-Matthies_2007, title={Zum Umgang mit Vielfalt im haushaltsbezogenen Unterricht}, volume={84}, number={1}, journal={Haushalt &#38; Bildung}, author={Schlegel-Matthies, Kirsten}, year={2007}, pages={35–46} }","apa":"Schlegel-Matthies, K. (2007). Zum Umgang mit Vielfalt im haushaltsbezogenen Unterricht. <i>Haushalt &#38; Bildung</i>, <i>84</i>(1), 35–46.","chicago":"Schlegel-Matthies, Kirsten. “Zum Umgang Mit Vielfalt Im Haushaltsbezogenen Unterricht.” <i>Haushalt &#38; Bildung</i> 84, no. 1 (2007): 35–46.","ieee":"K. Schlegel-Matthies, “Zum Umgang mit Vielfalt im haushaltsbezogenen Unterricht,” <i>Haushalt &#38; Bildung</i>, vol. 84, no. 1, pp. 35–46, 2007.","ama":"Schlegel-Matthies K. Zum Umgang mit Vielfalt im haushaltsbezogenen Unterricht. <i>Haushalt &#38; Bildung</i>. 2007;84(1):35-46."},"issue":"1","title":"Zum Umgang mit Vielfalt im haushaltsbezogenen Unterricht","date_updated":"2022-01-06T06:57:47Z","volume":84,"date_created":"2021-11-25T19:48:22Z","author":[{"first_name":"Kirsten","last_name":"Schlegel-Matthies","full_name":"Schlegel-Matthies, Kirsten","id":"459"}]},{"publication_status":"published","issue":"2","year":"2007","citation":{"ama":"Schlegel-Matthies K. Vermittlung von Konsum- und Finanzkompetenzen für Kinder und Jugendliche - Möglichkeiten und Grenzen pädagogischen Handelns. <i>Der pädagogische Blick Zeitschrift für Wissenschaft und Praxis in pädagogischen Berufen</i>. 2007;15(2):89-96.","chicago":"Schlegel-Matthies, Kirsten. “Vermittlung von Konsum- und Finanzkompetenzen für Kinder und Jugendliche - Möglichkeiten und Grenzen pädagogischen Handelns.” <i>Der pädagogische Blick. Zeitschrift für Wissenschaft und Praxis in pädagogischen Berufen</i> 15, no. 2 (2007): 89–96.","ieee":"K. Schlegel-Matthies, “Vermittlung von Konsum- und Finanzkompetenzen für Kinder und Jugendliche - Möglichkeiten und Grenzen pädagogischen Handelns,” <i>Der pädagogische Blick. Zeitschrift für Wissenschaft und Praxis in pädagogischen Berufen</i>, vol. 15, no. 2, pp. 89–96, 2007.","apa":"Schlegel-Matthies, K. (2007). Vermittlung von Konsum- und Finanzkompetenzen für Kinder und Jugendliche - Möglichkeiten und Grenzen pädagogischen Handelns. <i>Der pädagogische Blick. Zeitschrift für Wissenschaft und Praxis in pädagogischen Berufen</i>, <i>15</i>(2), 89–96.","bibtex":"@article{Schlegel-Matthies_2007, title={Vermittlung von Konsum- und Finanzkompetenzen für Kinder und Jugendliche - Möglichkeiten und Grenzen pädagogischen Handelns}, volume={15}, number={2}, journal={Der pädagogische Blick. Zeitschrift für Wissenschaft und Praxis in pädagogischen Berufen}, author={Schlegel-Matthies, Kirsten}, year={2007}, pages={89–96} }","mla":"Schlegel-Matthies, Kirsten. “Vermittlung von Konsum- und Finanzkompetenzen für Kinder und Jugendliche - Möglichkeiten und Grenzen pädagogischen Handelns.” <i>Der pädagogische Blick. Zeitschrift für Wissenschaft und Praxis in pädagogischen Berufen</i>, vol. 15, no. 2, 2007, pp. 89–96.","short":"K. Schlegel-Matthies, Der pädagogische Blick. Zeitschrift für Wissenschaft und Praxis in pädagogischen Berufen 15 (2007) 89–96."},"page":"89-96","intvolume":"        15","date_updated":"2022-01-06T06:57:47Z","date_created":"2021-11-25T19:51:03Z","author":[{"first_name":"Kirsten","last_name":"Schlegel-Matthies","id":"459","full_name":"Schlegel-Matthies, Kirsten"}],"volume":15,"title":"Vermittlung von Konsum- und Finanzkompetenzen für Kinder und Jugendliche - Möglichkeiten und Grenzen pädagogischen Handelns","type":"journal_article","publication":"Der pädagogische Blick. Zeitschrift für Wissenschaft und Praxis in pädagogischen Berufen","status":"public","_id":"27890","user_id":"49428","department":[{"_id":"35"},{"_id":"22"},{"_id":"396"}],"language":[{"iso":"ger"}]},{"title":"REVIS - Moderne Ernährungs- und Verbraucherbildung","publisher":"aid","date_updated":"2022-01-06T06:57:48Z","date_created":"2021-11-25T20:03:38Z","author":[{"first_name":"A.","last_name":"Oepping","full_name":"Oepping, A."},{"id":"459","full_name":"Schlegel-Matthies, Kirsten","last_name":"Schlegel-Matthies","first_name":"Kirsten"}],"year":"2007","place":"Bonn","citation":{"apa":"Oepping, A., &#38; Schlegel-Matthies, K. (2007). <i>REVIS - Moderne Ernährungs- und Verbraucherbildung</i>. aid.","mla":"Oepping, A., and Kirsten Schlegel-Matthies. <i>REVIS - Moderne Ernährungs- und Verbraucherbildung</i>. aid, 2007.","bibtex":"@book{Oepping_Schlegel-Matthies_2007, place={Bonn}, title={REVIS - Moderne Ernährungs- und Verbraucherbildung}, publisher={aid}, author={Oepping, A. and Schlegel-Matthies, Kirsten}, year={2007} }","short":"A. Oepping, K. Schlegel-Matthies, REVIS - Moderne Ernährungs- und Verbraucherbildung, aid, Bonn, 2007.","ama":"Oepping A, Schlegel-Matthies K. <i>REVIS - Moderne Ernährungs- und Verbraucherbildung</i>. aid; 2007.","chicago":"Oepping, A., and Kirsten Schlegel-Matthies. <i>REVIS - Moderne Ernährungs- und Verbraucherbildung</i>. Bonn: aid, 2007.","ieee":"A. Oepping and K. Schlegel-Matthies, <i>REVIS - Moderne Ernährungs- und Verbraucherbildung</i>. Bonn: aid, 2007."},"publication_status":"published","language":[{"iso":"ger"}],"_id":"27891","user_id":"459","department":[{"_id":"35"},{"_id":"22"},{"_id":"396"}],"status":"public","type":"book"},{"has_accepted_license":"1","page":"499--505","citation":{"ama":"Fischer M, Laroque C, Huber D, et al. Interactive Refinement of a Material Flow Simulation Model by Comparing Multiple Simulation Runs in one 3D Environment. In: <i>European Simulation and Modelling Conference (ESM 2007)</i>. ; 2007:499--505.","chicago":"Fischer, Matthias, Christoph  Laroque, Daniel  Huber, Jens  Krokowski, Bengt  Mueck, Michael  Kortenjan, Mark Aufenanger, and Wilhelm  Dangelmaier. “Interactive Refinement of a Material Flow Simulation Model by Comparing Multiple Simulation Runs in One 3D Environment.” In <i>European Simulation and Modelling Conference (ESM 2007)</i>, 499--505, 2007.","ieee":"M. Fischer <i>et al.</i>, “Interactive Refinement of a Material Flow Simulation Model by Comparing Multiple Simulation Runs in one 3D Environment,” in <i>European Simulation and Modelling Conference (ESM 2007)</i>, 2007, pp. 499--505.","apa":"Fischer, M., Laroque, C., Huber, D., Krokowski, J., Mueck, B., Kortenjan, M., …  Dangelmaier, W. (2007). Interactive Refinement of a Material Flow Simulation Model by Comparing Multiple Simulation Runs in one 3D Environment. In <i>European Simulation and Modelling Conference (ESM 2007)</i> (pp. 499--505).","short":"M. Fischer, C. Laroque, D. Huber, J. Krokowski, B. Mueck, M. Kortenjan, M. Aufenanger, W.  Dangelmaier, in: European Simulation and Modelling Conference (ESM 2007), 2007, pp. 499--505.","bibtex":"@inproceedings{Fischer_Laroque_Huber_Krokowski_Mueck_Kortenjan_Aufenanger_ Dangelmaier_2007, title={Interactive Refinement of a Material Flow Simulation Model by Comparing Multiple Simulation Runs in one 3D Environment}, booktitle={European Simulation and Modelling Conference (ESM 2007)}, author={Fischer, Matthias and Laroque, Christoph  and Huber, Daniel  and Krokowski, Jens  and Mueck, Bengt  and Kortenjan, Michael  and Aufenanger, Mark and  Dangelmaier, Wilhelm}, year={2007}, pages={499--505} }","mla":"Fischer, Matthias, et al. “Interactive Refinement of a Material Flow Simulation Model by Comparing Multiple Simulation Runs in One 3D Environment.” <i>European Simulation and Modelling Conference (ESM 2007)</i>, 2007, pp. 499--505."},"year":"2007","date_created":"2020-08-26T09:23:24Z","author":[{"last_name":"Fischer","id":"146","full_name":"Fischer, Matthias","first_name":"Matthias"},{"first_name":"Christoph ","full_name":"Laroque, Christoph ","last_name":"Laroque"},{"first_name":"Daniel ","last_name":"Huber","full_name":"Huber, Daniel "},{"last_name":"Krokowski","full_name":"Krokowski, Jens ","first_name":"Jens "},{"first_name":"Bengt ","full_name":"Mueck, Bengt ","last_name":"Mueck"},{"full_name":"Kortenjan, Michael ","last_name":"Kortenjan","first_name":"Michael "},{"first_name":"Mark","full_name":"Aufenanger, Mark","last_name":"Aufenanger"},{"first_name":"Wilhelm","last_name":" Dangelmaier","full_name":" Dangelmaier, Wilhelm"}],"date_updated":"2022-01-06T06:53:29Z","title":"Interactive Refinement of a Material Flow Simulation Model by Comparing Multiple Simulation Runs in one 3D Environment","publication":"European Simulation and Modelling Conference (ESM 2007)","type":"conference","status":"public","file":[{"content_type":"application/pdf","success":1,"relation":"main_file","date_updated":"2020-08-26T09:22:47Z","creator":"koala","date_created":"2020-08-26T09:22:47Z","file_size":389588,"access_level":"closed","file_name":"ESM07_final.pdf","file_id":"18348"}],"abstract":[{"lang":"eng","text":"The validation of material flow models as well as the selection of promising strategies for the generation of a successful experiment plan is a time-consuming process. A new approach is presented, which supports the simulation expert in his working process by giving him the opportunity to modify the simulated simulation run and afterwards compare the effects of his modification with the original setting, online and in one user interface, implemented by switching the visualizations between the simulation runs or opening up to 5 parallel 3D windows. The method developed therefore clones existing simulation runs online and allows the navigation within these existing simulation runs. The method has been implemented and is validated by a test model, which describes in detail the new working process of a modeler. New research questions are derived from this work, which will define following working steps.\r\n"}],"department":[{"_id":"63"}],"user_id":"15415","_id":"18347","file_date_updated":"2020-08-26T09:22:47Z","language":[{"iso":"eng"}],"ddc":["004"]},{"language":[{"iso":"eng"}],"_id":"18349","series_title":"Verlagsschriftenreihe des Heinz Nixdorf Instituts, Paderborn","user_id":"5786","department":[{"_id":"63"},{"_id":"26"}],"status":"public","type":"conference","publication":"Augmented & Virtual Reality in der Produktentstehung","title":"Ein ganzheitlicher Ansatz zur immersiven 3D-Materialflusssimulation innerhalb der Digitalen Fabrik","date_updated":"2022-01-06T06:53:29Z","publisher":"Verlagsschriftenreihe des Heinz Nixdorf Instituts, Paderborn","author":[{"last_name":"Dangelmaier","full_name":"Dangelmaier, Wilhelm","first_name":"Wilhelm"},{"full_name":" Laroque, Christoph ","last_name":" Laroque","first_name":"Christoph "},{"last_name":"Fischer","full_name":"Fischer, Matthias","id":"146","first_name":"Matthias"}],"date_created":"2020-08-26T09:30:58Z","volume":209,"year":"2007","citation":{"chicago":"Dangelmaier, Wilhelm, Christoph   Laroque, and Matthias Fischer. “Ein Ganzheitlicher Ansatz Zur Immersiven 3D-Materialflusssimulation Innerhalb Der Digitalen Fabrik.” In <i>Augmented &#38; Virtual Reality in Der Produktentstehung</i>, 209:95–110. Verlagsschriftenreihe Des Heinz Nixdorf Instituts, Paderborn. Verlagsschriftenreihe des Heinz Nixdorf Instituts, Paderborn, 2007.","ieee":"W. Dangelmaier, C.  Laroque, and M. Fischer, “Ein ganzheitlicher Ansatz zur immersiven 3D-Materialflusssimulation innerhalb der Digitalen Fabrik,” in <i>Augmented &#38; Virtual Reality in der Produktentstehung</i>, 2007, vol. 209, pp. 95–110.","ama":"Dangelmaier W,  Laroque C, Fischer M. Ein ganzheitlicher Ansatz zur immersiven 3D-Materialflusssimulation innerhalb der Digitalen Fabrik. In: <i>Augmented &#38; Virtual Reality in Der Produktentstehung</i>. Vol 209. Verlagsschriftenreihe des Heinz Nixdorf Instituts, Paderborn. Verlagsschriftenreihe des Heinz Nixdorf Instituts, Paderborn; 2007:95-110.","bibtex":"@inproceedings{Dangelmaier_ Laroque_Fischer_2007, series={Verlagsschriftenreihe des Heinz Nixdorf Instituts, Paderborn}, title={Ein ganzheitlicher Ansatz zur immersiven 3D-Materialflusssimulation innerhalb der Digitalen Fabrik}, volume={209}, booktitle={Augmented &#38; Virtual Reality in der Produktentstehung}, publisher={Verlagsschriftenreihe des Heinz Nixdorf Instituts, Paderborn}, author={Dangelmaier, Wilhelm and  Laroque, Christoph  and Fischer, Matthias}, year={2007}, pages={95–110}, collection={Verlagsschriftenreihe des Heinz Nixdorf Instituts, Paderborn} }","short":"W. Dangelmaier, C.  Laroque, M. Fischer, in: Augmented &#38; Virtual Reality in Der Produktentstehung, Verlagsschriftenreihe des Heinz Nixdorf Instituts, Paderborn, 2007, pp. 95–110.","mla":"Dangelmaier, Wilhelm, et al. “Ein Ganzheitlicher Ansatz Zur Immersiven 3D-Materialflusssimulation Innerhalb Der Digitalen Fabrik.” <i>Augmented &#38; Virtual Reality in Der Produktentstehung</i>, vol. 209, Verlagsschriftenreihe des Heinz Nixdorf Instituts, Paderborn, 2007, pp. 95–110.","apa":"Dangelmaier, W.,  Laroque, C., &#38; Fischer, M. (2007). Ein ganzheitlicher Ansatz zur immersiven 3D-Materialflusssimulation innerhalb der Digitalen Fabrik. <i>Augmented &#38; Virtual Reality in Der Produktentstehung</i>, <i>209</i>, 95–110."},"intvolume":"       209","page":"95-110"},{"publication":"Proceedings of the 10th International Symposium on Modeling Analysis and Simulation of Wireless and Mobile Systems, MSWiM 2007, Chania, Crete Island, Greece, October 22-26, 2007","type":"conference","status":"public","department":[{"_id":"75"}],"user_id":"15572","_id":"832","page":"36--44","citation":{"short":"D. H. Woldegebreal, S. Valentin, H. Karl, in: Proceedings of the 10th International Symposium on Modeling Analysis and Simulation of Wireless and Mobile Systems, MSWiM 2007, Chania, Crete Island, Greece, October 22-26, 2007, 2007, pp. 36--44.","bibtex":"@inproceedings{H. Woldegebreal_Valentin_Karl_2007, title={Outage probability analysis of cooperative transmission protocols without and with network coding: inter-user channels based comparison}, DOI={<a href=\"https://doi.org/10.1145/1298126.1298136\">10.1145/1298126.1298136</a>}, booktitle={Proceedings of the 10th International Symposium on Modeling Analysis and Simulation of Wireless and Mobile Systems, MSWiM 2007, Chania, Crete Island, Greece, October 22-26, 2007}, author={H. Woldegebreal, Dereje and Valentin, Stefan and Karl, Holger}, year={2007}, pages={36--44} }","mla":"H. 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Woldegebreal D, Valentin S, Karl H. Outage probability analysis of cooperative transmission protocols without and with network coding: inter-user channels based comparison. In: <i>Proceedings of the 10th International Symposium on Modeling Analysis and Simulation of Wireless and Mobile Systems, MSWiM 2007, Chania, Crete Island, Greece, October 22-26, 2007</i>. ; 2007:36--44. doi:<a href=\"https://doi.org/10.1145/1298126.1298136\">10.1145/1298126.1298136</a>","chicago":"H. Woldegebreal, Dereje, Stefan Valentin, and Holger Karl. “Outage Probability Analysis of Cooperative Transmission Protocols without and with Network Coding: Inter-User Channels Based Comparison.” In <i>Proceedings of the 10th International Symposium on Modeling Analysis and Simulation of Wireless and Mobile Systems, MSWiM 2007, Chania, Crete Island, Greece, October 22-26, 2007</i>, 36--44, 2007. <a href=\"https://doi.org/10.1145/1298126.1298136\">https://doi.org/10.1145/1298126.1298136</a>.","ieee":"D. H. Woldegebreal, S. Valentin, and H. Karl, “Outage probability analysis of cooperative transmission protocols without and with network coding: inter-user channels based comparison,” in <i>Proceedings of the 10th International Symposium on Modeling Analysis and Simulation of Wireless and Mobile Systems, MSWiM 2007, Chania, Crete Island, Greece, October 22-26, 2007</i>, 2007, pp. 36--44."},"year":"2007","date_created":"2017-11-27T10:22:27Z","author":[{"first_name":"Dereje","last_name":"H. Woldegebreal","full_name":"H. Woldegebreal, Dereje"},{"first_name":"Stefan","full_name":"Valentin, Stefan","last_name":"Valentin"},{"first_name":"Holger","last_name":"Karl","full_name":"Karl, Holger","id":"126"}],"date_updated":"2022-01-06T07:03:53Z","doi":"10.1145/1298126.1298136","title":"Outage probability analysis of cooperative transmission protocols without and with network coding: inter-user channels based comparison"},{"_id":"34681","series_title":"Kolloquium Fremdsprachenunterricht ","user_id":"616","language":[{"iso":"ger"}],"extern":"1","type":"conference","publication":"Band zur Tagung: Multilateralität und europäischer Bildungsauftrag, Bremen (20.-22. Juni 2006)","editor":[{"first_name":"D.","last_name":"Elsner","full_name":"Elsner, D."},{"first_name":"L. ","full_name":"Küster, L. 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Juni 2006)</i>, Bremen, 2007, vol. 31, pp. 165–178.","chicago":"Behrent, Sigrid. “En route vers un but commun: Besonderheiten der Kommunikation zwischen Sprachlernern und Implikationen für die Fremdsprachendidaktik.” In <i>Band zur Tagung: Multilateralität und europäischer Bildungsauftrag, Bremen (20.-22. Juni 2006)</i>, edited by D. Elsner, L.  Küster, and B. Viebrock, 31:165–78. Kolloquium Fremdsprachenunterricht . Frankfurt a.M.: Peter Lang, 2007.","ama":"Behrent S. En route vers un but commun: Besonderheiten der Kommunikation zwischen Sprachlernern und Implikationen für die Fremdsprachendidaktik. In: Elsner D, Küster L, Viebrock B, eds. <i>Band zur Tagung: Multilateralität und europäischer Bildungsauftrag, Bremen (20.-22. Juni 2006)</i>. Vol 31. Kolloquium Fremdsprachenunterricht . Peter Lang; 2007:165-178.","apa":"Behrent, S. (2007). En route vers un but commun: Besonderheiten der Kommunikation zwischen Sprachlernern und Implikationen für die Fremdsprachendidaktik. In D. Elsner, L. Küster, &#38; B. Viebrock (Eds.), <i>Band zur Tagung: Multilateralität und europäischer Bildungsauftrag, Bremen (20.-22. Juni 2006)</i> (Vol. 31, pp. 165–178). Peter Lang.","bibtex":"@inproceedings{Behrent_2007, place={Frankfurt a.M.}, series={Kolloquium Fremdsprachenunterricht }, title={En route vers un but commun: Besonderheiten der Kommunikation zwischen Sprachlernern und Implikationen für die Fremdsprachendidaktik.}, volume={31}, booktitle={Band zur Tagung: Multilateralität und europäischer Bildungsauftrag, Bremen (20.-22. Juni 2006)}, publisher={Peter Lang}, author={Behrent, Sigrid}, editor={Elsner, D. and Küster, L.  and Viebrock, B.}, year={2007}, pages={165–178}, collection={Kolloquium Fremdsprachenunterricht } }","short":"S. Behrent, in: D. Elsner, L. Küster, B. Viebrock (Eds.), Band zur Tagung: Multilateralität und europäischer Bildungsauftrag, Bremen (20.-22. Juni 2006), Peter Lang, Frankfurt a.M., 2007, pp. 165–178.","mla":"Behrent, Sigrid. “En route vers un but commun: Besonderheiten der Kommunikation zwischen Sprachlernern und Implikationen für die Fremdsprachendidaktik.” <i>Band zur Tagung: Multilateralität und europäischer Bildungsauftrag, Bremen (20.-22. Juni 2006)</i>, edited by D. Elsner et al., vol. 31, Peter Lang, 2007, pp. 165–78."},"page":"165-178","intvolume":"        31"},{"type":"conference","publication":"Human Interface and the Management of Information. Interacting in Information Environments, Symposium on Human Interface 2007, Held as Part of HCI International 2007, Beijing, China, July 22-27, 2007, Proceedings, Part II","status":"public","editor":[{"first_name":"Michael J.","full_name":"Smith, Michael J.","last_name":"Smith"},{"first_name":"Gavriel","full_name":"Salvendy, Gavriel","last_name":"Salvendy"}],"series_title":"Lecture Notes in Computer Science","user_id":"405","_id":"24068","language":[{"iso":"eng"}],"keyword":["Ver{\\"],"publication_identifier":{"isbn":["978-3-540-73353-9"]},"quality_controlled":"1","citation":{"apa":"Koch, R., Harnasch, R., Lee, B.-S., &#38; Pottebaum, J. (2007). Rapid and Precise Mobile Data Processing for Fire Brigades and Rescue Services (SAFeR/GÜTER/SHARE). In M. J. Smith &#38; G. Salvendy (Eds.), <i>Human Interface and the Management of Information. Interacting in Information Environments, Symposium on Human Interface 2007, Held as Part of HCI International 2007, Beijing, China, July 22-27, 2007, Proceedings, Part II</i> (pp. 1050–1059). Springer. <a href=\"https://doi.org/10.1007/978-3-540-73354-6_114\">https://doi.org/10.1007/978-3-540-73354-6_114</a>","short":"R. Koch, R. Harnasch, B.-S. Lee, J. Pottebaum, in: M.J. Smith, G. Salvendy (Eds.), Human Interface and the Management of Information. 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Rapid and Precise Mobile Data Processing for Fire Brigades and Rescue Services (SAFeR/GÜTER/SHARE). In: Smith MJ, Salvendy G, eds. <i>Human Interface and the Management of Information. Interacting in Information Environments, Symposium on Human Interface 2007, Held as Part of HCI International 2007, Beijing, China, July 22-27, 2007, Proceedings, Part II</i>. Lecture Notes in Computer Science. Springer; 2007:1050-1059. doi:<a href=\"https://doi.org/10.1007/978-3-540-73354-6_114\">10.1007/978-3-540-73354-6_114</a>","chicago":"Koch, Rainer, Rüdiger Harnasch, Bo-Sik Lee, and Jens Pottebaum. “Rapid and Precise Mobile Data Processing for Fire Brigades and Rescue Services (SAFeR/GÜTER/SHARE).” In <i>Human Interface and the Management of Information. Interacting in Information Environments, Symposium on Human Interface 2007, Held as Part of HCI International 2007, Beijing, China, July 22-27, 2007, Proceedings, Part II</i>, edited by Michael J. Smith and Gavriel Salvendy, 1050–59. 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D., Krueger, B., Posern, G., &#38; Goppelt-Struebe, M. (2007). Actin-dependent regulation of connective tissue growth factor. <i>American Journal of Physiology-Cell Physiology</i>, <i>292</i>(5), C1732–C1738. <a href=\"https://doi.org/10.1152/ajpcell.00552.2006\">https://doi.org/10.1152/ajpcell.00552.2006</a>","short":"S. Muehlich, I. Cicha, C.D. Garlichs, B. Krueger, G. Posern, M. Goppelt-Struebe, American Journal of Physiology-Cell Physiology 292 (2007) C1732–C1738.","bibtex":"@article{Muehlich_Cicha_Garlichs_Krueger_Posern_Goppelt-Struebe_2007, title={Actin-dependent regulation of connective tissue growth factor}, volume={292}, DOI={<a href=\"https://doi.org/10.1152/ajpcell.00552.2006\">10.1152/ajpcell.00552.2006</a>}, number={5}, journal={American Journal of Physiology-Cell Physiology}, publisher={American Physiological Society}, author={Muehlich, Susanne and Cicha, Iwona and Garlichs, Christoph D. and Krueger, Bettina and Posern, Guido and Goppelt-Struebe, Margarete}, year={2007}, pages={C1732–C1738} }","mla":"Muehlich, Susanne, et al. “Actin-Dependent Regulation of Connective Tissue Growth Factor.” <i>American Journal of Physiology-Cell Physiology</i>, vol. 292, no. 5, American Physiological Society, 2007, pp. C1732–C1738, doi:<a href=\"https://doi.org/10.1152/ajpcell.00552.2006\">10.1152/ajpcell.00552.2006</a>.","ama":"Muehlich S, Cicha I, Garlichs CD, Krueger B, Posern G, Goppelt-Struebe M. Actin-dependent regulation of connective tissue growth factor. <i>American Journal of Physiology-Cell Physiology</i>. 2007;292(5):C1732–C1738. doi:<a href=\"https://doi.org/10.1152/ajpcell.00552.2006\">10.1152/ajpcell.00552.2006</a>","ieee":"S. Muehlich, I. Cicha, C. D. Garlichs, B. Krueger, G. Posern, and M. Goppelt-Struebe, “Actin-dependent regulation of connective tissue growth factor,” <i>American Journal of Physiology-Cell Physiology</i>, vol. 292, no. 5, pp. C1732–C1738, 2007, doi: <a href=\"https://doi.org/10.1152/ajpcell.00552.2006\">10.1152/ajpcell.00552.2006</a>.","chicago":"Muehlich, Susanne, Iwona Cicha, Christoph D. Garlichs, Bettina Krueger, Guido Posern, and Margarete Goppelt-Struebe. “Actin-Dependent Regulation of Connective Tissue Growth Factor.” <i>American Journal of Physiology-Cell Physiology</i> 292, no. 5 (2007): C1732–C1738. <a href=\"https://doi.org/10.1152/ajpcell.00552.2006\">https://doi.org/10.1152/ajpcell.00552.2006</a>."},"publisher":"American Physiological Society","date_updated":"2024-06-30T13:50:05Z","volume":292,"date_created":"2024-06-30T13:49:55Z","author":[{"first_name":"Susanne","full_name":"Muehlich, Susanne","last_name":"Muehlich"},{"last_name":"Cicha","full_name":"Cicha, Iwona","first_name":"Iwona"},{"last_name":"Garlichs","full_name":"Garlichs, Christoph D.","first_name":"Christoph D."},{"full_name":"Krueger, Bettina","id":"49428","orcid":"0000-0001-5351-1785","last_name":"Krueger","first_name":"Bettina"},{"last_name":"Posern","full_name":"Posern, Guido","first_name":"Guido"},{"full_name":"Goppelt-Struebe, Margarete","last_name":"Goppelt-Struebe","first_name":"Margarete"}],"title":"Actin-dependent regulation of connective tissue growth factor","doi":"10.1152/ajpcell.00552.2006","publication":"American Journal of Physiology-Cell Physiology","type":"journal_article","abstract":[{"text":"Expression of connective tissue growth factor (CTGF) in endothelial cells is modulated by shear stress affecting the organization of the cytoskeleton. The molecular connection between alterations of actin and CTGF expression was investigated in human umbilical vein endothelial cells (HUVEC) and a microvascular endothelial cell line. Overexpression of nonpolymerizable monomeric actin R62D interfered with stress fiber formation in HUVEC and concomitantly reduced immunoreactive CTGF. In microvascular endothelial cells, flow-dependent upregulation of CTGF was prevented by this actin mutant. In contrast, overexpression of actin S14C strengthened filamentous actin and increased CTGF expression. These data indicated an inverse relationship between CTGF expression and monomeric actin. Coexpression of the mutant actins and different CTGF promoter constructs revealed an actin-sensitive site between 3 and 4.5 kb of the CTGF promoter. A CArG-like box at -3791 bp was responsible for actin-dependent CTGF induction as shown by mutagenesis. Overexpression of actin S14C activated the nonmutated promoter significantly more strongly than the mutated promoter. Actin polymerization is regulated by the small GTPase RhoA and activation of serum response factor (SRF). Overexpression of constitutively active RhoA or SRF significantly increased CTGF protein synthesis. The 4.5-kb promoter construct, but not the construct with a mutation in the CArG box, was activated by SRF or RhoA, providing evidence for a functional role of this site in CTGF induction. These findings provide novel evidence that monomeric actin is the connecting link between alterations in the cytoskeleton and CTGF gene expression and demonstrate the importance of SRF in regulating CTGF transcription.","lang":"eng"}],"status":"public","_id":"54935","department":[{"_id":"35"},{"_id":"22"}],"user_id":"49428","language":[{"iso":"eng"}]}]