@article{22637, abstract = {{Abstract Doxorubicin (DOX) is a common drug in cancer chemotherapy, and its high DNA-binding affinity can be harnessed in preparing DOX-loaded DNA nanostructures for targeted delivery and therapeutics. Although DOX has been widely studied, the existing literature of DOX-loaded DNA-carriers remains limited and incoherent. Here, based on an in-depth spectroscopic analysis, we characterize and optimize the DOX loading into different 2D and 3D scaffolded DNA origami nanostructures (DONs). In our experimental conditions, all DONs show similar DOX binding capacities (one DOX molecule per two to three base pairs), and the binding equilibrium is reached within seconds, remarkably faster than previously acknowledged. To characterize drug release profiles, DON degradation and DOX release from the complexes upon DNase I digestion was studied. For the employed DONs, the relative doses (DOX molecules released per unit time) may vary by two orders of magnitude depending on the DON superstructure. In addition, we identify DOX aggregation mechanisms and spectral changes linked to pH, magnesium, and DOX concentration. These features have been largely ignored in experimenting with DNA nanostructures, but are probably the major sources of the incoherence of the experimental results so far. Therefore, we believe this work can act as a guide to tailoring the release profiles and developing better drug delivery systems based on DNA-carriers.}}, author = {{Ijäs, Heini and Shen, Boxuan and Heuer-Jungemann, Amelie and Keller, Adrian and Kostiainen, Mauri A and Liedl, Tim and Ihalainen, Janne A and Linko, Veikko}}, issn = {{0305-1048}}, journal = {{Nucleic Acids Research}}, pages = {{3048--3062}}, title = {{{Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release}}}, doi = {{10.1093/nar/gkab097}}, volume = {{49}}, year = {{2021}}, } @article{23023, abstract = {{DNA origami nanostructures (DONs) are promising substrates for the single-molecule investigation of biomolecular reactions and dynamics by in situ atomic force microscopy (AFM). For this, they are typically immobilized on mica substrates by adding millimolar concentrations of Mg2+ ions to the sample solution, which enable the adsorption of the negatively charged DONs at the like-charged mica surface. These non-physiological Mg2+ concentrations, however, present a serious limitation in such experiments as they may interfere with the reactions and processes under investigation. Therefore, we here evaluate three approaches to efficiently immobilize DONs at mica surfaces under essentially Mg2+-free conditions. These approaches rely on the pre-adsorption of different multivalent cations, i.e., Ni2+, poly-l-lysine (PLL), and spermidine (Spdn). DON adsorption is studied in phosphate-buffered saline (PBS) and pure water. In general, Ni2+ shows the worst performance with heavily deformed DONs. For 2D DON triangles, adsorption at PLL- and in particular Spdn-modified mica may outperform even Mg2+-mediated adsorption in terms of surface coverage, depending on the employed solution. For 3D six-helix bundles, less pronounced differences between the individual strategies are observed. Our results provide some general guidance for the immobilization of DONs at mica surfaces under Mg2+-free conditions and may aid future in situ AFM studies.}}, author = {{Xin, Yang and Zargariantabrizi, Amir Ardalan and Grundmeier, Guido and Keller, Adrian}}, issn = {{1420-3049}}, journal = {{Molecules}}, pages = {{4798}}, title = {{{Magnesium-Free Immobilization of DNA Origami Nanostructures at Mica Surfaces for Atomic Force Microscopy}}}, doi = {{10.3390/molecules26164798}}, volume = {{26}}, year = {{2021}}, } @article{30906, abstract = {{Abstract Background Hand amputation can have a truly debilitating impact on the life of the affected person. A multifunctional myoelectric prosthesis controlled using pattern classification can be used to restore some of the lost motor abilities. However, learning to control an advanced prosthesis can be a challenging task, but virtual and augmented reality (AR) provide means to create an engaging and motivating training. Methods In this study, we present a novel training framework that integrates virtual elements within a real scene (AR) while allowing the view from the first-person perspective. The framework was evaluated in 13 able-bodied subjects and a limb-deficient person divided into intervention (IG) and control (CG) groups. The IG received training by performing simulated clothespin task and both groups conducted a pre- and posttest with a real prosthesis. When training with the AR, the subjects received visual feedback on the generated grasping force. The main outcome measure was the number of pins that were successfully transferred within 20 min (task duration), while the number of dropped and broken pins were also registered. The participants were asked to score the difficulty of the real task (posttest), fun-factor and motivation, as well as the utility of the feedback. Results The performance (median/interquartile range) consistently increased during the training sessions (4/3 to 22/4). While the results were similar for the two groups in the pretest, the performance improved in the posttest only in IG. In addition, the subjects in IG transferred significantly more pins (28/10.5 versus 14.5/11), and dropped (1/2.5 versus 3.5/2) and broke (5/3.8 versus 14.5/9) significantly fewer pins in the posttest compared to CG. The participants in IG assigned (mean ± std) significantly lower scores to the difficulty compared to CG (5.2 ± 1.9 versus 7.1 ± 0.9), and they highly rated the fun factor (8.7 ± 1.3) and usefulness of feedback (8.5 ± 1.7). Conclusion The results demonstrated that the proposed AR system allows for the transfer of skills from the simulated to the real task while providing a positive user experience. The present study demonstrates the effectiveness and flexibility of the proposed AR framework. Importantly, the developed system is open source and available for download and further development. }}, author = {{Boschmann, Alexander and Neuhaus, Dorothee and Vogt, Sarah and Kaltschmidt, Christian and Platzner, Marco and Dosen, Strahinja}}, issn = {{1743-0003}}, journal = {{Journal of NeuroEngineering and Rehabilitation}}, keywords = {{Health Informatics, Rehabilitation}}, number = {{1}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Immersive augmented reality system for the training of pattern classification control with a myoelectric prosthesis}}}, doi = {{10.1186/s12984-021-00822-6}}, volume = {{18}}, year = {{2021}}, } @inproceedings{26821, author = {{Wibbeke, Tim Michael and Bartley, Auerélie and Chudalla, Nick and Meschut, Gerson}}, booktitle = {{Fahrzeug + Karosserie und kfz-betrieb (Hrsg,); Tagungsband zu den Würzburger Karosserie- und Schadenstagen 22./23. Oktober 2021}}, title = {{{Fügen und Trennen von Kfz-Karosseriestrukturen in Leichtbauweise}}}, year = {{2021}}, } @article{33008, author = {{Ludwig-Walz, Helena and Nyasordzi, Juliana and Weber, Katharina S. and Buyken, Anette and Kroke, Anja}}, issn = {{0939-4753}}, journal = {{Nutrition, Metabolism and Cardiovascular Diseases}}, keywords = {{Cardiology and Cardiovascular Medicine, Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous)}}, number = {{4}}, pages = {{833--852}}, publisher = {{Elsevier BV}}, title = {{{Maternal pregnancy weight or gestational weight gain and offspring's blood pressure: A systematic review}}}, doi = {{10.1016/j.numecd.2021.11.011}}, volume = {{32}}, year = {{2021}}, } @article{27575, abstract = {{There is a distinct increase in the prevalence of depression with the onset of puberty. The role of peripubertal testosterone levels in boys in this context is insufficiently understood and may be modulated by a functional polymorphism of the androgen receptor gene (AR), a variable number of CAG repeats. Moreover, there is preliminary evidence that the relationship between testosterone, CAG repeat length, and the severity of depressive symptoms may differ between subclinical and overt depression, but this has neither been studied in a clinical sample of adolescents with depression nor compared between subclinical and overt depression in an adequately powered study. To investigate the relationship between free testosterone, CAG repeat length of the AR, depression status (subclinical vs. overt), and the severity of depressive symptoms, 118 boys treated as in- or daycare patients at a single psychiatric hospital were studied. Of these, 73 boys had at least mild depressive symptoms according to the Beck Depression Inventory-II (BDI-II &gt; 13). Higher-order moderation analysis in the multiple regression framework revealed a constant relationship between free testosterone and depression severity irrespective of the number of CAG repeats in adolescents with a BDI-II score ≤ 13. In adolescents with a BDI-II score &gt; 13, however, there was a significant negative relationship between free testosterone and BDI-II score in patients with &lt;19 CAG repeats and a significant positive relationship regarding free testosterone and BDI-II score in those with more than 28 CAG repeats, even when considering important covariates. These results suggest that the effects of testosterone on mood in male adolescents with depression depend on the genetic make-up of the AR as well as on depression status. This complex relationship should be considered by future studies addressing mental health issues against an endocrine background and may, moreover, contribute to tailored treatment concepts in psychiatric medicine, especially in adults.}}, author = {{Hirtz, Raphael and Libuda, Lars and Hinney, Anke and Föcker, Manuel and Bühlmeier, Judith and Holterhus, Paul-Martin and Kulle, Alexandra and Kiewert, Cordula and Hebebrand, Johannes and Grasemann, Corinna}}, issn = {{1664-0640}}, journal = {{Frontiers in Psychiatry}}, title = {{{Size Matters: The CAG Repeat Length of the Androgen Receptor Gene, Testosterone, and Male Adolescent Depression Severity}}}, doi = {{10.3389/fpsyt.2021.732759}}, year = {{2021}}, } @article{27571, abstract = {{(1) Background: Evidence has accumulated that patients with anorexia nervosa (AN) are at higher risk for vitamin D deficiency than healthy controls. In epidemiologic studies, low 25(OH) vitamin D (25(OH)D) levels were associated with depression. This study analyzed the relationship between 25(OH)D serum levels in adolescent patients and AN and depressive symptoms over the course of treatment. (2) Methods: 25(OH)D levels and depressive symptoms were analyzed in 93 adolescent (in-)patients with AN from the Anorexia Nervosa Day patient versus Inpatient (ANDI) multicenter trial at clinic admission, discharge, and 1 year follow up. Mixed regression models were used to analyze the relationship between 25(OH)D levels and depressive symptoms assessed by the Beck Depression Inventory (BDI-II). (3) Results: Although mean 25(OH)D levels constantly remained in recommended ranges (≥50 nmol/L) during AN treatment, levels decreased from (in)patient admission to 1 year follow up. Levels of 25(OH)D were neither cross-sectionally, prospectively, nor longitudinally associated with the BDI-II score. (4) Conclusions: This study did not confirm that 25(OH)D levels are associated with depressive symptoms in patients with AN. However, increasing risks of vitamin D deficiency over the course of AN treatment indicate that clinicians should monitor 25(OH)D levels.}}, author = {{Föcker, Manuel and Timmesfeld, Nina and Bühlmeier, Judith and Zwanziger, Denise and Führer, Dagmar and Grasemann, Corinna and Ehrlich, Stefan and Egberts, Karin and Fleischhaker, Christian and Wewetzer, Christoph and Wessing, Ida and Seitz, Jochen and Herpertz-Dahlmann, Beate and Hebebrand, Johannes and Libuda, Lars}}, issn = {{2072-6643}}, journal = {{Nutrients}}, title = {{{Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms}}}, doi = {{10.3390/nu13072356}}, year = {{2021}}, } @article{26632, abstract = {{AbstractAnorexia nervosa (AN) is a severe eating disorder and often associated with altered humoral immune responses. However, distinct B cell maturation stages in peripheral blood in adolescents with AN have not been characterized. Treatment effects and the relationship between clinical and B cell parameters are also not fully understood. Here we investigated the phenotype of circulating B cell subsets and the relationship with body composition in adolescents with AN before (T0, n = 24) and after 6 weeks (T1, n = 20) of treatment. Using multi-parameter flow cytometry, we found increased percentages of antigen-experienced B cells and plasmablasts in patients with AN compared to healthy controls (n = 20). In contrast, percentages of CD1d+CD5+ B cells and transitional B cells with immunoregulatory roles were reduced at T0 and T1. These B cell frequencies correlated positively with fat mass, fat mass index (FMI), free fat mass index, and body mass index standard deviation score. In addition, scavenger-like receptor CD5 expression levels were downregulated on transitional B cells and correlated with fat mass and FMI in AN. Our findings that regulatory B cell subgroups were reduced in AN and their strong relationship with body composition parameters point toward an impact of immunoregulatory B cells in the pathogenesis of AN.}}, author = {{Freff, Jana and Schwarte, Kathrin and Bröker, Lisa and Bühlmeier, Judith and Kraft, Isabelle and Öztürk, Dana and Hinney, Anke and Arolt, Volker and Dannlowski, Udo and Romer, Georg and Baune, Bernhard T. and Hebebrand, Johannes and Föcker, Manuel and Alferink, Judith}}, issn = {{2045-2322}}, journal = {{Scientific Reports}}, title = {{{Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa}}}, doi = {{10.1038/s41598-020-80693-4}}, year = {{2021}}, } @article{26525, author = {{Hebebrand, Johannes and Antel, Jochen and Tan, Susanne and Wabitsch, Martin and Wiesing, Urban and Barth, Nikolaus and Ludwig, Christine and Bühlmeier, Judith and Libuda, Lars and Milos, Gabriella and Hinney, Anke}}, issn = {{1422-4917}}, journal = {{Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie}}, pages = {{1--5}}, title = {{{Kurzzeitige Behandlung von Patient_innen mit Anorexia nervosa mit rekombinant hergestelltem Human-Leptin (Metreleptin): Rasch einsetzende positive Effekte auf Stimmung, Kognition und Verhalten}}}, doi = {{10.1024/1422-4917/a000775}}, year = {{2021}}, } @article{30683, abstract = {{When joining lightweight parts of various materials, clinching is a cost efficient solution. In a production line, the quality of a clinch point is primarily controlled by measurement of dimensions, which are accessible from outside. However, methods such as visual testing and measuring the bottom thickness as well as the outer diameter are not able to deliver any information about the most significant geometrical characteristic of the clinch point, neck thickness and undercut. Furthermore, ex-situ destructive methods such as microsectioning cannot detect elastic deformations and cracks that close after unloading. In order to exceed the current limits, a new non-destructive in-situ testing method for the clinching process is necessary. This work proposes a concept to characterize clinch points in-situ by combining two complementary non-destructive methods, namely, computed tomography (CT) and ultrasonic testing. Firstly, clinch points with different geometrical characteristics are analysed experimentally using ex-situ CT to get a highly spatially resolved 3D-image of the object. In this context, highly X-ray attenuating materials enhancing the visibility of the sheet-sheet interface are investigated. Secondly, the test specimens are modelled using finite element method (FEM) and a transient dynamic analysis (TDA) is conducted to study the effect of the geometrical differences on the deformation energy and to qualify the TDA as a fast in-situ non-destructive method for characterizing clinch points at high temporal resolution. }}, author = {{Köhler, D. and Sadeghian, B. and Kupfer, R. and Troschitz, J. and Gude, M. and Brosius, A.}}, journal = {{Key Engineering Materials}}, pages = {{89--96}}, title = {{{A Method for Characterization of Geometric Deviations in Clinch Points with Computed Tomography and Transient Dynamic Analysis}}}, doi = {{10.4028/www.scientific.net/kem.883.89}}, volume = {{883}}, year = {{2021}}, } @article{35303, abstract = {{Abstract Purpose Studies about effects of lunch dietary Glycemic Index (GI) on cognition of schoolchildren are scarce. Our previous CogniDo GI study found no changes of cognition in the early postprandial phase after consumption of two rice types with medium vs. high dietary GI for lunch (i.e., 45 min after starting lunch). This study investigated whether the dietary GI of lunch has an impact on cognition of schoolchildren in the late postprandial phase, 90 min after lunch. Methods A randomized, 2 × 2 crossover intervention study was conducted at a comprehensive school with 5th and 6th grade students. Participants (n = 212) were randomly assigned to either sequence 1 or 2. In the first period, participants of sequence 1 received a dish with high GI rice (GI: 79), those of sequence 2 with medium GI rice (GI: 64)—in the second period, 1 week later, vice versa. Computer-based cognitive testing was performed 90 min after lunch examining tonic alertness, visual search and task switching, and working memory. Treatment effects and treatment effects adjusted for estimated lunch glycemic load (GL) were analyzed using a linear mixed model. Results The selected cognitive parameters were not affected by the GI of lunch 90 min after lunch, neither after intention-to-treat nor in the per-protocol analysis. Adjustment for GL also did not change results. Conclusion The present study revealed no notable differences after the consumption of two rice types with medium vs. high dietary GI for lunch in children’s cognitive function in the late postprandial phase, 90 min after lunch. Clinical trial registration German Clinical Trials Register (DRKS00013597); date of registration: 16/04/2018, retrospectively registered. }}, author = {{Drozdowska, Alina and Sinningen, Kathrin and Falkenstein, Michael and Rudolf, Henrik and Libuda, Lars and Buyken, Anette and Lücke, Thomas and Kersting, Mathilde}}, issn = {{1436-6207}}, journal = {{European Journal of Nutrition}}, keywords = {{Nutrition and Dietetics, Medicine (miscellaneous)}}, number = {{3}}, pages = {{1637--1647}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Impact of lunch with carbohydrates differing in glycemic index on children's cognitive functioning in the late postprandial phase: a randomized crossover study}}}, doi = {{10.1007/s00394-021-02766-y}}, volume = {{61}}, year = {{2021}}, } @inbook{35774, author = {{Albers, Timm and Filipiak, Agnes and Franzen, Katja and Hellmich, Frank}}, booktitle = {{Grenzen. Gänge. Zwischen. Welten. Kontroversen – Entwicklungen – Perspektiven der Inklusionsforschung}}, editor = {{Schimek, Bernhard and Kremsner, Gertraud and Proyer, Michelle and Grubich, Rainer and Paudel, Florentine and Grubich-Müller, Regina}}, pages = {{207–214}}, publisher = {{Verlag Julius Klinkhardt}}, title = {{{Kompetenzentwicklung im inklusiven Unterricht (KinU) – eine internationale Perspektive}}}, doi = {{10.35468/5924-22}}, year = {{2021}}, } @article{47977, abstract = {{Orange-colored crystals of the oxoferrate tellurate K12+6xFe6Te4−xO27 [x=0.222(4)] were synthesized in a potassium hydroxide hydroflux with a molar water–base ratio n(H2O)/n(KOH) of 1.5 starting from Fe(NO3)3 ⋅ 9H2O, TeO2 and H2O2 at about 200 °C. By using (NH4)2TeO4 instead of TeO2, a fine powder consisting of microcrystalline spheres of K12+6xFe6Te4−xO27 was obtained. K12+6xFe6Te4−xO27 crystallizes in the acentric cubic space group Iurn:x-wiley:09476539:media:chem202102464:chem202102464-math-0001 3d. [FeIIIO5] pyramids share their apical atoms in [Fe2O9] groups and two of their edges with [TeVIO6] octahedra to form an open framework that consists of two loosely connected, but not interpenetrating, chiral networks. The flexibility of the hinged oxometalate network manifests in a piezoelectric response similar to that of LiNbO3.The potassium cations are mobile in channels that run along the <111> directions and cross in cavities acting as nodes. The ion conductivity of cold-pressed pellets of ball-milled K12+6xFe6Te4−xO27 is 2.3×10^(−4) S ⋅ cm^(−1) at room temperature. Magnetization measurements and neutron diffraction indicate antiferromagnetic coupling in the [Fe2O9] groups.}}, author = {{Albrecht, Ralf and Hoelzel, Markus and Beccard, Henrik and Rüsing, Michael and Eng, Lukas and Doert, Thomas and Ruck, Michael}}, issn = {{0947-6539}}, journal = {{Chemistry – A European Journal}}, keywords = {{General Chemistry, Catalysis, Organic Chemistry}}, number = {{57}}, pages = {{14299--14306}}, publisher = {{Wiley}}, title = {{{Potassium Ion Conductivity in the Cubic Labyrinth of a Piezoelectric, Antiferromagnetic Oxoferrate(III) Tellurate(VI)}}}, doi = {{10.1002/chem.202102464}}, volume = {{27}}, year = {{2021}}, } @article{47564, author = {{Reitze, Arnulf and Grünewald, Marcus and Riese, Julia}}, issn = {{0888-5885}}, journal = {{Industrial & Engineering Chemistry Research}}, keywords = {{Industrial and Manufacturing Engineering, General Chemical Engineering, General Chemistry}}, number = {{1}}, pages = {{740--746}}, publisher = {{American Chemical Society (ACS)}}, title = {{{Characterization of Liquid-Phase Distribution in 3D Printed Structured Packings with an Enclosed Column Wall}}}, doi = {{10.1021/acs.iecr.1c03931}}, volume = {{61}}, year = {{2021}}, } @phdthesis{52665, author = {{Hillebrand, Michael}}, isbn = {{978-3-947647-22-4}}, title = {{{Entwicklungssystematik zur Integration von Eigenschaften der Selbstheilung in Intelligente Technische Systeme }}}, volume = {{Band 403}}, year = {{2021}}, } @article{35744, author = {{Biehler, Rolf and Weigand, Hans-Georg}}, journal = {{mathematik lehren}}, number = {{228}}, pages = {{2–5}}, publisher = {{Friedrich Verlag}}, title = {{{3D-Geometrie–virtuell und real}}}, volume = {{2021}}, year = {{2021}}, } @article{35761, author = {{Höper, Lukas and Malin, Leah and Biehler, Rolf}}, journal = {{mathematik lehren}}, number = {{228}}, pages = {{19–22}}, publisher = {{Friedrich Verlag}}, title = {{{Schatten von 3D-Objekten: Modellierung mit GeoGebra 3D und Anwendungen in der Computergrafik}}}, volume = {{2021}}, year = {{2021}}, } @article{35763, author = {{Hüsing, Sven and Weiser, Niklas and Biehler, Rolf}}, journal = {{mathematik lehren}}, number = {{228}}, pages = {{23–27}}, publisher = {{Friedrich Verlag}}, title = {{{Faszination 3D-Film: Entwicklung einer 3D-Konstruktion}}}, volume = {{2021}}, year = {{2021}}, } @article{27508, abstract = {{To analyze the influence of suspension kinematics on tire wear, detailed simulation models are required. In this study, a non-linear, flexible multibody model of a rear axle system is built up in the simulation software MSC Adams/View. The physical model comprises the suspension kinematics, compliance, and dynamics as well as the non-linear behavior of the tire using the FTire model. FTire is chosen because it has a separate tire tread model to compute the contact pressure and friction force distribution in the tire contact patch. To build up the simulation model, a large amount of data is needed. Bushings, spring, and damper characteristics are modeled based on measurements. For the structural components (e.g., control arms), reverse engineering techniques are used. The components are 3D-scanned, reworked, and included as a modal reduced finite element (FE)-model using component mode synthesis by Craig–Bampton. Finally, the suspension model is validated by comparing the simulated kinematic and compliance characteristics to experimental results. To investigate the interaction of suspension kinematics and tire wear, straight line driving events, such as acceleration, driving with constant velocity, and deceleration, are simulated with different setups of wheel suspension kinematics. The influence of the setups on the resulting friction work between tire and road is examined, and an exemplarily calculation of tire wear based on a validated FTire tire model is carried out. The results demonstrate, on the one hand, that the chosen concept of elasto-kinematic axle leads to a relatively good match with experimental results and, on the other hand, that there are significant possibilities to reduce tire wear by adjusting the suspension kinematics.}}, author = {{Schütte, Jan and Sextro, Walter}}, issn = {{2624-8921}}, journal = {{Vehicles}}, pages = {{233--256}}, title = {{{Tire Wear Reduction Based on an Extended Multibody Rear Axle Model}}}, doi = {{10.3390/vehicles3020015}}, year = {{2021}}, } @article{45844, abstract = {{Abstract Abductive reasoning is a non-monotonic formalism stemming from the work of Peirce. It describes the process of deriving the most plausible explanations of known facts. Considering the positive version, asking for sets of variables as explanations, we study, besides the problem of wether there exists a set of explanations, two explanation size limited variants of this reasoning problem (less than or equal to, and equal to a given size bound). In this paper, we present a thorough two-dimensional classification of these problems: the first dimension is regarding the parameterized complexity under a wealth of different parameterizations, and the second dimension spans through all possible Boolean fragments of these problems in Schaefer’s constraint satisfaction framework with co-clones (T. J. Schaefer. The complexity of satisfiability problems. In Proceedings of the 10th Annual ACM Symposium on Theory of Computing, May 1–3, 1978, San Diego, California, USA, R.J. Lipton, W.A. Burkhard, W.J. Savitch, E.P. Friedman, A.V. Aho eds, pp. 216–226. ACM, 1978). Thereby, we almost complete the parameterized complexity classification program initiated by Fellows et al. (The parameterized complexity of abduction. In Proceedings of the Twenty-Sixth AAAI Conference on Articial Intelligence, July 22–26, 2012, Toronto, Ontario, Canada, J. Homann, B. Selman eds. AAAI Press, 2012), partially building on the results by Nordh and Zanuttini (What makes propositional abduction tractable. Artificial Intelligence, 172, 1245–1284, 2008). In this process, we outline a fine-grained analysis of the inherent parameterized intractability of these problems and pinpoint their FPT parts. As the standard algebraic approach is not applicable to our problems, we develop an alternative method that makes the algebraic tools partially available again.}}, author = {{Mahmood, Yasir and Meier, Arne and Schmidt, Johannes}}, issn = {{0955-792X}}, journal = {{Journal of Logic and Computation}}, keywords = {{Logic, Hardware and Architecture, Arts and Humanities (miscellaneous), Software, Theoretical Computer Science}}, number = {{1}}, pages = {{266--296}}, publisher = {{Oxford University Press (OUP)}}, title = {{{Parameterized complexity of abduction in Schaefer’s framework}}}, doi = {{10.1093/logcom/exaa079}}, volume = {{31}}, year = {{2021}}, }