@article{24312, author = {{Vogtschmidt, Sascha and Fiebig, Isabel and Schöppner, Volker}}, journal = {{Joining Plastics}}, number = {{3-4}}, title = {{{Wechseldehnungsschweißen - Entwicklung einer Fügetechnologie für 3D-Geometrien}}}, year = {{2020}}, } @inproceedings{24318, author = {{Vogtschmidt, Sascha and Schöppner, Volker}}, booktitle = {{DVS CONGRESS 2020 - Große Schweißtechnische Tagung}}, title = {{{Wechseldehnungsschweißen - Entwicklung einer Fügetechnologie für 3D-Geometrien}}}, volume = {{365}}, year = {{2020}}, } @inproceedings{24478, author = {{Moritzer, Elmar and Wächter, Julian}}, location = {{Karlsruhe}}, title = {{{From filament production to material qualification for the FDM process}}}, year = {{2020}}, } @article{26526, author = {{Gappa, Monika and Filipiak‐Pittroff, Birgit and Libuda, Lars and Berg, Andrea and Koletzko, Sibylle and Bauer, Carl‐Peter and Heinrich, Joachim and Schikowski, Tamara and Berdel, Dietrich and Standl, Marie}}, issn = {{0105-4538}}, journal = {{Allergy}}, pages = {{1903--1907}}, title = {{{Long‐term effects of hydrolyzed formulae on atopic diseases in the GINI study}}}, doi = {{10.1111/all.14709}}, year = {{2020}}, } @article{26527, abstract = {{Abstract Background While observational studies revealed an inverse association between serum 25(OH)vitamin D (25(OH)D) and the risk of attention deficit/hyperactivity disorder (ADHD), the causality of this relationship remains unclear. Methods We conducted a bidirectional two-sample Mendelian Randomization (MR) study to examine whether 25(OH)D has an effect on the risk to develop ADHD or vice versa. Information on single nucleotide polymorphisms (SNP) associated with serum 25(OH)D was obtained from a genome-wide association study (GWAS) considering phenotype data from 79,366 individuals of European ancestry. Data on risk for ADHD were derived from a GWAS analysis with 20,183 individuals diagnosed with ADHD and 35,191 controls. For our analysis, we considered effect sizes based on the European participants (19,099 cases and 34,194 controls). Results Single SNP analyses showed a causal effect of vitamin D on ADHD risk for only one SNP (rs12785878, p = 0.024). The overall MR estimates did not reveal a causal effect of 25(OH)D on risk for ADHD. In the reverse analysis, neither any single nor the multi-SNP MR analyses showed a causal effect of ADHD on 25(OH)D. Conclusion Results from this two-sample MR study did not confirm a causal effect of 25(OH)D on ADHD or vice versa. Accordingly, our study does not provide evidence that improving 25(OH)D via supplementation could reduce the risk of developing ADHD. }}, author = {{Libuda, Lars and Naaresh, Roaa and Ludwig, Christine and Laabs, Björn-Hergen and Antel, Jochen and Föcker, Manuel and Hebebrand, Johannes and Hinney, Anke and Peters, Triinu}}, issn = {{1436-6207}}, journal = {{European Journal of Nutrition}}, pages = {{2581--2591}}, title = {{{A mendelian randomization study on causal effects of 25(OH)vitamin D levels on attention deficit/hyperactivity disorder}}}, doi = {{10.1007/s00394-020-02439-2}}, year = {{2020}}, } @article{26529, abstract = {{Abstract Purpose The influences of nutrition in childhood on puberty onset could have sustained consequences for health and wellbeing later in life. The aim of this study was to investigate the prospective association of diet quality prior to puberty with the timing of puberty onset. Methods We considered data from 3983 SCCNG (Southwest China Childhood Nutrition and Growth) study participants with dietary data, anthropometric measurement, and information on potential confounders at their baseline assessment (mean age: 7.1 years for girls and 7.3 years for boys; mean length of follow-up was 4.2 years). Cox proportional hazard regression estimating hazard ratios (HRs) and 95% confidence intervals (CIs) were used to examine the relationship between diet quality and puberty onset. Dietary intake at baseline was assessed using a validated food frequency questionnaire. Diet quality was determined using the Chinese Children Dietary Index (CCDI) which measures adherence to current dietary recommendations (theoretical range: 0–160 points). Age at Tanner stage 2 for breast/genital development (B2/G2), menarche or voice break (M/VB) were used as pubertal markers. Results The CCDI score ranged from 56.2 to 136.3 for girls and 46.1–131.5 for boys. Pubertal markers consistently indicate that girls and boys with higher diet quality were more likely to enter their puberty later than their counterparts with lower CCDI scores (higher vs. lower CCDI tertiles: adjusted HR for age at B2: 0.85 (95% CI, 0.81–0.94), p for trend = 0.02; G2: 0.86 (95% CI,0.80–0.96), p for trend = 0.02; M: 0.86 (95% CI,0.80–0.95), p for trend = 0.02; VB: 0.86 (95% CI,0.79–0.98), p for trend = 0.03), after adjustment for paternal education level, baseline energy intake, and pre-pubertal body fat. Conclusions Our data suggested a later puberty onset and later timing of progressed puberty stages in children with a high diet quality, which were independent of pre-pubertal body fat. }}, author = {{Duan, Ruonan and Qiao, Tian and Chen, Yue and Chen, Mengxue and Xue, Hongmei and Zhou, Xue and Yang, Mingzhe and Liu, Yan and Zhao, Li and Libuda, Lars and Cheng, Guo}}, issn = {{1436-6207}}, journal = {{European Journal of Nutrition}}, pages = {{2423--2434}}, title = {{{The overall diet quality in childhood is prospectively associated with the timing of puberty}}}, doi = {{10.1007/s00394-020-02425-8}}, year = {{2020}}, } @book{26872, author = {{Klünder, Nina}}, pages = {{135}}, publisher = {{Beltz Juventa}}, title = {{{Die Ernährungsversorgung in Familien zwischen Zeit, Alltag und Haushaltsführung. Eine Mixed-Methods-Untersuchung}}}, year = {{2020}}, } @techreport{26886, author = {{Müller, Heinz and Klünder, Nina}}, pages = {{74}}, title = {{{Der Jugendamts-Monitor. Aufgaben – Trends – Daten}}}, year = {{2020}}, } @article{27013, abstract = {{AbstractFlavonoids are suggested to reduce disease risk. Since dietary habits are acquired during early life, describing age and time trends of flavonoid intake and major food sources are important for monitoring and disease prevention in later life. We aimed to describe total flavonoid intake and food sources and to investigate age and time trends of flavonoid intake in 3–18-year-olds, from the Dortmund Nutritional and Anthropometric Longitudinally Designed study from 1985 to 2016. Intake was assessed annually using 3-d weighed food records (WFR). Flavonoid values were assigned using the United States Department of Agriculture database. Foods contributing to intake were determined. Age and time trends in total flavonoid and isoflavone density were analysed by sex with PROC MIXED. In total, 1312 children completed 10 758 WFR. Across all ages, daily mean total flavonoid density was lower in boys compared with girls (134 v. 146 mg/4184 kJ) and no difference in median isoflavone density (0·04 mg/4184 kJ per d) was found. The top five foods contributing to total flavonoid intake were apple with peel (15·0/17·1 %), strawberries (5·9/6·1 %), chocolate spread (3·9/3·5 %), orange juice (3·5/3·4 %) and pasta (3·5/3·4 %) for boys and girls, respectively. Overall, in boys, total flavonoid density decreased over the course of age and time. In girls, there was no association with age or time. In both sexes, isoflavone density followed a U-shaped age trend with no change over time. From a public health perspective, the overall observed downwards trend of flavonoid intake in boys deserves attention. Future initiatives should be tailored at maintaining a high flavonoid density as children age, specifically among boys.}}, author = {{Rienks, Johanna and Penczynski, Katharina J. and Schmitting, Sarah and Buyken, Anette and Nöthlings, Ute}}, issn = {{0007-1145}}, journal = {{British Journal of Nutrition}}, pages = {{1198--1206}}, title = {{{Dietary flavonoids among children and adolescents in the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study: intake, food sources and trends from 1985 until 2016}}}, doi = {{10.1017/s000711452000183x}}, year = {{2020}}, } @article{27019, abstract = {{AbstractTo examine the hypothesis that normalization of low circulating leptin levels in patients with anorexia nervosa ameliorates hyperactivity, three seriously ill females with hyperactivity were treated off-label with metreleptin (recombinant human leptin) for up to 14 days. Drive for activity, repetitive thoughts of food, inner restlessness, and weight phobia decreased in two patients. Surprisingly, depression improved rapidly in all patients. No serious adverse events occurred. Due to obvious limitations of uncontrolled case series, placebo-controlled clinical trials are mandatory to confirm the observed rapid onset of beneficial effects. Our findings suggest an important role of hypoleptinemia in the mental and behavioral phenotype of anorexia nervosa.}}, author = {{Milos, Gabriella and Antel, Jochen and Kaufmann, Lisa-Katrin and Barth, Nikolaus and Koller, Antonia and Tan, Susanne and Wiesing, Urban and Hinney, Anke and Libuda, Lars and Wabitsch, Martin and von Känel, Roland and Hebebrand, Johannes}}, issn = {{2158-3188}}, journal = {{Translational Psychiatry}}, title = {{{Short-term metreleptin treatment of patients with anorexia nervosa: rapid on-set of beneficial cognitive, emotional, and behavioral effects}}}, doi = {{10.1038/s41398-020-00977-1}}, year = {{2020}}, } @article{27020, author = {{Peters, Triinu and Nüllig, Lena and Antel, Jochen and Naaresh, Roaa and Laabs, Björn-Hergen and Tegeler, Lisa and Amhaouach, Chaima and Libuda, Lars and Hinney, Anke and Hebebrand, Johannes}}, issn = {{1664-8021}}, journal = {{Frontiers in Genetics}}, title = {{{The Role of Genetic Variation of BMI, Body Composition, and Fat Distribution for Mental Traits and Disorders: A Look-Up and Mendelian Randomization Study}}}, doi = {{10.3389/fgene.2020.00373}}, year = {{2020}}, } @article{27795, author = {{Kupriyanova, Yuliya and Zaharia, Oana Patricia and Bobrov, Pavel and Karusheva, Yanislava and Burkart, Volker and Szendroedi, Julia and Hwang, Jong-Hee and Roden, Michael and Roden, M. and Al-Hasani, H. and Burkart, V. and Buyken, Anette and Geerling, G. and Hwang, J.H. and Herder, C. and Icks, A. and Jandeleit-Dahm, K. and Kahl, S. and Kotzka, J. and Kuss, O. and Lammert, E. and Trenkamp, S. and Rathmann, W. and Szendroedi, J. and Ziegler, D.}}, issn = {{0168-8278}}, journal = {{Journal of Hepatology}}, pages = {{1028--1037}}, title = {{{Early changes in hepatic energy metabolism and lipid content in recent-onset type 1 and 2 diabetes mellitus}}}, doi = {{10.1016/j.jhep.2020.11.030}}, year = {{2020}}, } @article{27797, abstract = {{Abstract Objective To provide a systematic overview of world dietary sugar and sugar-sweetened beverage (SSB) intake trends in children and adolescents. Data Sources Medline, Embase, and the Cochrane Central Register of Controlled Trials in the Cochrane Library were searched through January 2019 to identify longitudinal follow-up studies with time-trend data and repeated cross-sectional studies. Data Extraction Data from studies reporting ≥ 2 measurements (sugars, SSB, or sweets/candy) over ≥ 2 years and included ≥ 20 healthy, normal- or overweight children or adolescents aged 1–19 years. Data Analysis Data from 43 articles (n = 4 prospective cohort studies; n = 39 repeated cross-sectional studies) from 15 countries (n = 8 European countries plus Australia, Canada, China, South Korea, Mexico, Russia, and the United States) are presented narratively. According to the risk of bias in nonrandomized studies of interventions tool, 34 studies were judged to have a moderate risk of bias, and 5 to have a serious risk of bias. Conclusions Consumption among US children and adolescents increased substantially in the decades preceding 2000, followed by a faster and continued decline. As a whole, other international intake trends did not reveal drastic increases and decreases in SSB and dietary sugars; they tended to change only slightly across 3 decades. }}, author = {{Della Corte, Karen and Fife, Jessica and Gardner, Alexis and Murphy, Britta L and Kleis, Linda and Della Corte, Dennis and Schwingshackl, Lukas and LeCheminant, James D and Buyken, Anette}}, issn = {{0029-6643}}, journal = {{Nutrition Reviews}}, pages = {{274--288}}, title = {{{World trends in sugar-sweetened beverage and dietary sugar intakes in children and adolescents: a systematic review}}}, doi = {{10.1093/nutrit/nuaa070}}, year = {{2020}}, } @article{27799, abstract = {{Dietary fibre is a generic term describing non-absorbed plant carbohydrates and small amounts of associated non-carbohydrate components. The main contributors of fibre to the diet are the cell walls of plant tissues, which are supramolecular polymer networks containing variable proportions of cellulose, hemicelluloses, pectic substances, and non-carbohydrate components, such as lignin. Other contributors of fibre are the intracellular storage oligosaccharides, such as fructans. A distinction needs to be made between intrinsic sources of dietary fibre and purified forms of fibre, given that the three-dimensional matrix of the plant cell wall confers benefits beyond fibre isolates. Movement through the digestive tract modifies the cell wall structure and may affect the interactions with the colonic microbes (e.g., small intestinally non-absorbed carbohydrates are broken down by bacteria to short-chain fatty acids, absorbed by colonocytes). These aspects, combined with the fibre associated components (e.g., micronutrients, polyphenols, phytosterols, and phytoestrogens), may contribute to the health outcomes seen with the consumption of dietary fibre. Therefore, where possible, processing should minimise the degradation of the plant cell wall structures to preserve some of its benefits. Food labelling should include dietary fibre values and distinguish between intrinsic and added fibre. Labelling may also help achieve the recommended intake of 14 g/1000 kcal/day.}}, author = {{Augustin, Livia S. A. and Aas, Anne-Marie and Astrup, Arnie and Atkinson, Fiona S. and Baer-Sinnott, Sara and Barclay, Alan W. and Brand-Miller, Jennie C. and Brighenti, Furio and Bullo, Monica and Buyken, Anette and Ceriello, Antonio and Ellis, Peter R. and Ha, Marie-Ann and Henry, Jeyakumar C. and Kendall, Cyril W. C. and La Vecchia, Carlo and Liu, Simin and Livesey, Geoffrey and Poli, Andrea and Salas-Salvadó, Jordi and Riccardi, Gabriele and Riserus, Ulf and Rizkalla, Salwa W. and Sievenpiper, John L. and Trichopoulou, Antonia and Usic, Kathy and Wolever, Thomas M. S. and Willett, Walter C. and Jenkins, David J. A.}}, issn = {{2072-6643}}, journal = {{Nutrients}}, title = {{{Dietary Fibre Consensus from the International Carbohydrate Quality Consortium (ICQC)}}}, doi = {{10.3390/nu12092553}}, year = {{2020}}, } @article{27800, abstract = {{ A lower 24-h urine pH (24h-pH), i.e., a higher renal excretion of free protons, at a given acid load to the body, denotes a reduction in the kidney’s capacity for net acid excretion (NAE). There is increasing evidence, not only for patients with type 2 diabetes but also for healthy individuals, that higher body fatness or waist circumference (WC) has a negative impact on renal function to excrete acids (NAE). We hypothesized that adiposity-related inflammation molecules might mediate this relation between adiposity and renal acid excretion function. Twelve biomarkers of inflammation were measured in fasting blood samples from 162 adult participants (18–25 yr old) of the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study who had undergone anthropometric measurements and collected 24-h urine samples. Both Baron and Kenny’s (B&K’s) steps to test mediation and causal mediation analysis were conducted to examine the potential mediatory roles of biomarkers of inflammation in the WC-24-h pH relationship after strictly controlling for laboratory-measured NAE. In B&K’s mediation analysis, leptin, soluble intercellular adhesion molecule 1 (sICAM-1), and adiponectin significantly associated with the outcome 24-h pH and attenuated the WC-pH relation. In agreement herewith, causal mediation analysis estimated the “natural indirect effects” of WC on 24-h pH via leptin ( P = 0.01) and adiponectin ( P = 0.03) to be significant, with a trend for sICAM-1 ( P = 0.09). The calculated proportions mediated by leptin, adiponectin, and sICAM-1 were 64%, 23%, and 12%, respectively. Both mediation analyses identified an inflammatory cytokine (leptin) and an anti-inflammatory cytokine (adiponectin) along with sICAM-1 as being potentially involved in mediating adiposity-related influences on renal acid excretion capacity. }}, author = {{Hua, Yifan and Herder, Christian and Kalhoff, Hermann and Buyken, Anette and Esche, Jonas and Krupp, Danika and Wudy, Stefan A. and Remer, Thomas}}, issn = {{1931-857X}}, journal = {{American Journal of Physiology-Renal Physiology}}, pages = {{F469--F475}}, title = {{{Inflammatory mediators in the adipo-renal axis: leptin, adiponectin, and soluble ICAM-1}}}, doi = {{10.1152/ajprenal.00257.2020}}, year = {{2020}}, } @article{27801, author = {{Nyasordzi, Juliana and Penczynski, Katharina and Remer, Thomas and Buyken, Anette}}, issn = {{1932-6203}}, journal = {{PLOS ONE}}, title = {{{Early life factors and their relevance to intima-media thickness of the common carotid artery in early adulthood}}}, doi = {{10.1371/journal.pone.0233227}}, year = {{2020}}, } @article{27803, author = {{Schwingshackl, Lukas and Neuenschwander, Manuela and Hoffmann, Georg and Buyken, Anette and Schlesinger, Sabrina}}, issn = {{0002-9165}}, journal = {{The American Journal of Clinical Nutrition}}, pages = {{917--918}}, title = {{{Reply to Khan et al.}}}, doi = {{10.1093/ajcn/nqaa006}}, year = {{2020}}, } @article{27806, abstract = {{AbstractTrend analyses based on dietary records suggest decreases in the intakes of total sugar (TS), added and free sugar since 2005 among children and adolescents in Germany. In terms of age trends, TS intake decreased with increasing age. However, self-reported sugar intake in epidemiological studies is criticised, as it may be prone to bias due to selective underreporting. Furthermore, adolescents are more susceptible to underreporting than children. We thus analysed time and age trends in urinary fructose excretion (FE), sucrose excretion (SE) and the sum of both (FE + SE) as biomarkers for sugar intake among 8·5–16·5-year-old adolescents. Urinary sugar excretion was measured by UPLC-MS/MS in 997 24-h urine samples collected from 239 boys and 253 girls participating in the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study cohort between 1990 and 2016. Time and age trends of log-transformed FE, SE and FE + SE were analysed using polynomial mixed-effects regression models. Between 1990 and 2016, FE as well as FE + SE decreased (linear time trend: P = 0·0272 and P < 0·0001, respectively). A minor increase in excretion during adolescence was confined to FE (linear age trend: P = 0·0017). The present 24-h excretion measurements support a previously reported dietary record-based decline in sugar intake since 2005. However, the previously seen dietary record-based decrease in TS from childhood to late adolescence was not confirmed by our biomarker analysis, suggesting a constant sugar intake for the period of adolescence.}}, author = {{Perrar, Ines and Gray, Nicola and Kuhnle, Gunter G. and Remer, Thomas and Buyken, Anette and Alexy, Ute}}, issn = {{0007-1145}}, journal = {{British Journal of Nutrition}}, pages = {{164--172}}, title = {{{Sugar intake among German adolescents: trends from 1990 to 2016 based on biomarker excretion in 24-h urine samples}}}, doi = {{10.1017/s0007114520000665}}, year = {{2020}}, } @article{27807, abstract = {{There is no question that elevated postprandial glycemia is a significant driver of common chronic diseases globally [...]}}, author = {{Brand-Miller, Jennie and Buyken, Anette}}, issn = {{2072-6643}}, journal = {{Nutrients}}, title = {{{The Relationship between Glycemic Index and Health}}}, doi = {{10.3390/nu12020536}}, year = {{2020}}, } @proceedings{21019, editor = {{Ahrendt, Wolfgang and Wehrheim, Heike}}, isbn = {{978-3-030-50994-1}}, publisher = {{Springer}}, title = {{{Tests and Proofs - 14th International Conference, TAP@STAF 2020, Bergen, Norway, June 22-23, 2020, Proceedings [postponed]}}}, doi = {{10.1007/978-3-030-50995-8}}, volume = {{12165}}, year = {{2020}}, }