@article{27731, author = {{Kühn, Tilman and Kroke, Anja and Remer, Thomas and Schönau, Eckhard and Buyken, Anette}}, issn = {{1740-8695}}, journal = {{Maternal & Child Nutrition}}, pages = {{642--649}}, title = {{{Is breastfeeding related to bone properties? A longitudinal analysis of associations between breastfeeding duration and pQCT parameters in children and adolescents}}}, doi = {{10.1111/j.1740-8709.2012.00443.x}}, year = {{2012}}, } @article{27753, author = {{Joslowski, G and Goletzke, J and Cheng, G and Günther, A L B and Bao, J and Brand-Miller, J C and Buyken, Anette}}, issn = {{0307-0565}}, journal = {{International Journal of Obesity}}, pages = {{1463--1471}}, title = {{{Prospective associations of dietary insulin demand, glycemic index, and glycemic load during puberty with body composition in young adulthood}}}, doi = {{10.1038/ijo.2011.241}}, year = {{2012}}, } @article{27766, author = {{Buyken, Anette and Alexy, U. and Kersting, M. and Remer, T.}}, issn = {{1436-9990}}, journal = {{Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz}}, pages = {{875--884}}, title = {{{Die DONALD Kohorte}}}, doi = {{10.1007/s00103-012-1503-6}}, year = {{2012}}, } @article{27767, author = {{von Kries, R. and Reulen, H. and Bayer, O. and Riedel, C. and Diethelm, K. and Buyken, Anette}}, issn = {{2047-6302}}, journal = {{Pediatric Obesity}}, pages = {{13--20}}, title = {{{Increase in prevalence of adiposity between the ages of 7 and 11 years reflects lower remission rates during this period}}}, doi = {{10.1111/j.2047-6310.2012.00084.x}}, year = {{2012}}, } @article{27786, author = {{Hauner, H. and Bechthold, A. and Boeing, H. and Brönstrup, A. and Buyken, Anette and Leschik-Bonnet, E. and Linseisen, J. and Schulze, M. and Strohm, D. and Wolfram, G.}}, issn = {{0012-0472}}, journal = {{DMW - Deutsche Medizinische Wochenschrift}}, pages = {{389--393}}, title = {{{Kohlenhydratzufuhr und Prävention ausgewählter ernährungsmitbedingter Krankheiten}}}, doi = {{10.1055/s-0031-1298916}}, year = {{2012}}, } @article{27787, author = {{Cheng, Guo and Buyken, Anette and Shi, Lijie and Karaolis-Danckert, Nadina and Kroke, Anja and Wudy, Stefan A and Degen, Gisela H and Remer, Thomas}}, issn = {{0029-6643}}, journal = {{Nutrition Reviews}}, pages = {{133--152}}, title = {{{Beyond overweight: nutrition as an important lifestyle factor influencing timing of puberty}}}, doi = {{10.1111/j.1753-4887.2011.00461.x}}, year = {{2012}}, } @inproceedings{1128, abstract = {{Our purpose is to perform data record extraction from onlineevent calendars exploiting sublanguage and domain characteristics. We therefore use so-called domain-dependent data (D³) completely based on language-specific key expressions and HTML patterns to recognize every single event given on the investigated web page. One of the most remarkable advantages of our method is that it does not require any additional classification steps based on machine learning algorithms or keyword extraction methods; it is a so-called one-step mining technique. Moreover, another important criteria is that our system is robust to DOM and layout modifications made by web designers. Thus, preliminary experimental results are provided to demonstrate proof-of-concept of such an approach tested on websites in the German opera domain. Furthermore, we could show that our proposed technique outperforms other data record mining applications run on event sites.}}, author = {{Lee, Yeong Su and Geierhos, Michaela and Song, Sa-Kwang and Jung, Hanmin}}, booktitle = {{Software Technology: Prooceedings, International Conference, SoftTech 2012, Cebu, Philippines, May 2012}}, editor = {{Chang, Chin-Chen and Gelogo, Yvette E. and Caytiles, Ronnie E.}}, issn = {{22871233}}, location = {{Cebu, Philippines}}, pages = {{134--139}}, publisher = {{SERSC}}, title = {{{A Proof-of-Concept of D³ Record Mining using Domain-Dependent Data}}}, volume = {{5}}, year = {{2012}}, } @article{21757, author = {{Koning, W. F.}}, journal = {{IEEE Computer Graphics and Applications}}, number = {{5}}, pages = {{81--83}}, publisher = {{IEEE}}, title = {{{Teaching 3D Computer Animation to Illustrators: The Instructor as Translator and Technical Director}}}, doi = {{10.1109/MCG.2012.106}}, volume = {{32}}, year = {{2012}}, } @inproceedings{788, author = {{Dannewitz, Christian and Herlich, Matthias and Karl, Holger}}, booktitle = {{37th Annual IEEE Conference on Local Computer Networks, Workshop Proceedings, Clearwater Beach, FL, USA, October 22-25, 2012}}, pages = {{1061----1069}}, title = {{{OpenNetInf - prototyping an information-centric Network Architecture}}}, doi = {{10.1109/LCNW.2012.6424044}}, year = {{2012}}, } @inproceedings{619, abstract = {{Dynamics in networks is caused by a variety of reasons, like nodes moving in 2D (or 3D) in multihop cellphone networks, joins and leaves in peer-to-peer networks, evolution in social networks, and many others. In order to understand such kinds of dynamics, and to design distributed algorithms that behave well under dynamics, many ways to model dynamics are introduced and analyzed w.r.t. correctness and eciency of distributed algorithms. In [16], Kuhn, Lynch, and Oshman have introduced a very general, worst case type model of dynamics: The edge set of the network may change arbitrarily from step to step, the only restriction is that it is connected at all times and the set of nodes does not change. An extended model demands that a xed connected subnetwork is maintained over each time interval of length T (T-interval dynamics). They have presented, among others, algorithms for counting the number of nodes under such general models of dynamics.In this paper, we generalize their models and algorithms by adding random edge faults, i.e., we consider fault-prone dynamic networks: We assume that an edge currently existing may fail to transmit data with some probability p. We rst observe that strong counting, i.e., each node knows the correct count and stops, is not possible in a model with random edge faults. Our main two positive results are feasibility and runtime bounds for weak counting, i.e., stopping is no longer required (but still a correct count in each node), and for strong counting with an upper bound, i.e., an upper bound N on n is known to all nodes.}}, author = {{Brandes, Philipp and Meyer auf der Heide, Friedhelm}}, booktitle = {{Proceedings of the 4th Workshop on Theoretical Aspects of Dynamic Distributed Systems (TADDS)}}, pages = {{9--14}}, title = {{{Distributed Computing in Fault-Prone Dynamic Networks}}}, doi = {{10.1145/2414815.2414818}}, year = {{2012}}, } @inproceedings{16408, abstract = {{We present a parallel rendering system for heterogeneous PC clusters to visualize massive models. One single, powerful visualization node is supported by a group of backend nodes with weak graphics performance. While the visualization node renders the visible objects, the backend nodes asynchronously perform visibility tests and supply the front end with visible scene objects. The visualization node stores only currently visible objects in its memory, while the scene is distributed among the backend nodes’ memory without redundancy. To efficiently compute the occlusion tests in spite of that each backend node stores only a fraction of the original geometry, we complete the scene by adding highly simplified versions of the objects stored on other nodes. We test our system with 15 backend nodes. It is able to render a ≈ 350,M polygons (≈ 8.5,GiB) large aircraft model with 20, to 30,fps and thus allows a walk-through in real-time. }}, author = {{Suess, Tim and Koch, Clemens and Jähn, Claudius and Fischer, Matthias and Meyer auf der Heide, Friedhelm}}, booktitle = {{Advances in Visual Computing}}, isbn = {{9783642331787}}, issn = {{0302-9743}}, pages = {{502--512}}, title = {{{Asynchronous Occlusion Culling on Heterogeneous PC Clusters for Distributed 3D Scenes}}}, doi = {{10.1007/978-3-642-33179-4_48}}, volume = {{7431}}, year = {{2012}}, } @inproceedings{22164, abstract = {{Generative production techniques have the advantage of manufacturing parts via an additive process without needing a forming tool. One of these additive manufacturing technologies is "Fused Deposition Modeling" (FDM). It is one of the most used additive manufacturing processes to produce prototypes and end-use parts. From a 3D-CAD data set, components and assemblies are manufactured out of thermoplastic material layer by layer by means of an additive process. An extrusion head deposits the molten thermoplastic filament to create each layer with a particular tool path. Due to the thermal fusion the material bonds with the layer beneath and solidifies. Thus a permanent bonding of two layers is formed. In this paper the mechanical data of parts, manufactured with the system Fortus 400mc from Stratasys with the material Ultem*9085 are presented. Tensile and flexural tests according to both, the ASTM and the ISO standard, are conducted. Test specimens are generated with the standard parameters of the native software in different build directions. The tests show different strength and strain characteristics that depend on the given structure as a result of the build direction. Furthermore tensile specimens according to the ASTM standard are generated with changed parameters of the native software to increase the mechanical strength properties. The results are compared to injection molded strength properties.}}, author = {{Bagsik, A. and Schöppner, Volker and Klemp, E.}}, booktitle = {{1st International Conference on Thermo-Mechanically Graded Materials}}, isbn = {{9783942267588}}, pages = {{129--134}}, title = {{{Tensile and Flexural Properties of Fused Deposition Modeling Parts Manufactured with ULTEM*9085}}}, volume = {{1}}, year = {{2012}}, } @inproceedings{22024, abstract = {{Generative production techniques have the advantage of manufacturing parts via an additive process without needing a forming tool. One of these additive manufacturing technologies is “Fused Deposition Modeling” (FDM). It is one of the most used additive manufacturing processes to produce prototypes and end-use parts. From a 3D-CAD data set, components and assemblies are manufactured out of thermoplastic material layer by layer by means of an additive process. An extrusion head deposits the molten thermoplastic filament to create each layer with a particular tool path. In this paper the mechanical data of parts, manufactured with the system Fortus 400mc from Stratasys with the material Ultem*9085 are presented. Tensile specimens are generated with the standard parameters as well as with changed parameters of the native software to analyze the influence of these parameters on the mechanical strength properties. The tensile tests show different strength and strain characteristics that depend on the given structure and as a result of the build direction. Furthermore the toolpath parameters have an effect on the strength characteristics and the break behavior. In addition, tensile specimens are tested under the influence of different temperatures and after a thermal cycling. }}, author = {{Bagsik, A. and Schöppner, Volker and Klemp, E.}}, booktitle = {{5th International Conference on Polymer and Mould Innovations}}, pages = {{266--272}}, publisher = {{Centre for Polymer and Material Technology, Univ. College, Ghent Univ.}}, title = {{{Extensive Analysis of the mechanical strength properties of Fused Deposition Modeling Parts manufactured with ULTEM 9085}}}, doi = {{https://www.tib.eu/de/suchen/id/TIBKAT%3A756276616}}, volume = {{5}}, year = {{2012}}, } @inbook{49699, author = {{Jacke, Christoph}}, booktitle = {{GLEIS 22 - Fünfundzwanzig Jahre Konzerte.}}, editor = {{Skroblin, David and Dietrich, Frank}}, pages = {{6--8}}, publisher = {{Oktober Verlag}}, title = {{{Der Club „Gleis 22". 25 Jahre andere Räume, andere Musiken, Kommunikation und Kreativität.}}}, year = {{2012}}, } @article{54937, abstract = {{Purpose: The epithelial sodium channel (ENaC) is typically expressed in sodium-absorbing epithelia. Several reports suggest that ENaC is also expressed in ocular tissues and may play a role in aqueous humor secretion and glaucoma. However, the precise localization of ENaC in the human eye is still unclear. Here, the authors studied ENaC expression in 12 normal human donor eyes and in six eyes of patients with glaucoma. Methods: Quantitative real-time PCR was used to investigate the expression of $\alpha$-, $\beta$-, $\gamma$-, and $\delta$-ENaC transcripts in ocular tissues. In addition, the authors performed immunohistochemical studies using recently generated antibodies against human $\beta$- and $\gamma$-ENaC. Results: At the mRNA level, all four ENaC subunits were found to be expressed in a wide range of ocular tissues from normal and glaucomatous human eyes, with the cornea, ciliary body, iris, and retina showing the highest expression levels. At the protein level, $\beta$- and $\gamma$-ENaC subunits showed distinct distribution patterns and could be immunolocalized primarily to the cell membranes of epithelial cells of the cornea and to the conjunctiva, iris, ciliary body, lens, and retinal pigment epithelium but also to vascular endothelial cells, smooth muscle cells, stromal cells, and retinal neurons. The authors found no altered mRNA level of any subunit in glaucomatous eyes. Conclusions: All four ENaC subunits ($\alpha$$\beta$$\gamma$$\delta$) are expressed in the normal human eye, with distinct localization of subunits possibly reflecting different functional states of the channel. The (patho-)physiological roles of ENaC in the various localizations in the eye remain to be determined.}}, author = {{Krueger, Bettina and Schlötzer-Schrehardt, Ursula and Haerteis, Silke and Zenkel, Matthias and Chankiewitz, Verena E. and Amann, Kerstin U. and Kruse, Friedrich E. and Korbmacher, Christoph}}, journal = {{Investigative Opthalmology & Visual Science}}, number = {{2}}, pages = {{596–604}}, publisher = {{Association for Research in Vision and Ophthalmology (ARVO)}}, title = {{{Four Subunits ($\alpha$$\beta$$\gamma$$\delta$) of the Epithelial Sodium Channel (ENaC) Are Expressed in the Human Eye in Various Locations}}}, doi = {{10.1167/iovs.11-8581}}, volume = {{53}}, year = {{2012}}, } @article{54930, abstract = {{Background: Increased expression of the pro-fibrotic protein connective tissue growth factor (CTGF) has been detected in injured kidneys and elevated urinary levels of CTGF are discussed as prognostic marker of chronic kidney disease. There is evidence that epithelial cells lining the renal tubular system contribute to uptake and secretion of CTGF. However, the role of different types of tubular epithelial cells in these processes so far has not been addressed in primary cultures of human cells. Results: Tubular epithelial cells of proximal and distal origin were isolated from human kidneys and cultured as polarized cells in insert wells. The pro-fibrotic stimuli lysophosphatidic acid (LPA) and transforming growth factor $\beta$ (TGF-$\beta$) were used to induce CTGF secretion.LPA activated CTGF secretion in proximal tubular cells when applied from either the apical or the basolateral side as shown by immunocytochemistry. CTGF was secreted exclusively to the apical side. Signaling pathways activated by LPA included MAP kinase and Rho kinase signaling. TGF-$\beta$ applied from either side also stimulated CTGF secretion primarily to the apical side with little basolateral release.Interestingly, TGF-$\beta$ activation induced different signaling pathways depending on the side of TGF-$\beta$ application. Smad signaling was almost exclusively activated from the basolateral side most prominently in cells of distal origin. Only part of these cells also synthesized CTGF indicating that Smad activation alone was not sufficient for CTGF induction. MAP kinases were involved in apical TGF-$\beta$-mediated activation of CTGF synthesis in proximal cells and a subset of epithelial cells of distal origin. This subpopulation of distal tubular cells was also able to internalize recombinant apical CTGF, in addition to proximal cells which were the main cells to take up exogenous CTGF. Conclusions: Analysis of polarized human primary renal epithelial cells in a transwell system shows that vectorial secretion of the pro-fibrotic protein CTGF depends on the cell type, the stimulus and the signaling pathway activated. In all conditions, CTGF was secreted mainly to the apical side upon TGF-$\beta$ and LPA treatment and therefore, likely contributes to increased urinary CTGF levels in vivo. Moreover, CTGF secreted basolaterally may be active as paracrine pro-fibrotic mediator.}}, author = {{Zuehlke, Jonathan and Ebenau, Astrid and Krueger, Bettina and Goppelt-Struebe, Margarete}}, journal = {{Cell Communication and Signaling}}, number = {{1}}, publisher = {{Springer}}, title = {{{Vectorial secretion of CTGF as a cell-type specific response to LPA and TGF-$\beta$ in human tubular epithelial cells}}}, doi = {{10.1186/1478-811x-10-25}}, volume = {{10}}, year = {{2012}}, } @article{54934, abstract = {{Aldosterone is thought to be the main hormone to stimulate the epithelial sodium channel (ENaC) in the aldosterone-sensitive distal nephron (ASDN) comprising the late distal convoluted tubule (DCT2), the connecting tubule (CNT) and the entire collecting duct (CD). There is immunohistochemical evidence for an axial gradient of ENaC expression along the ASDN with highest expression in the DCT2 and CNT. However, most of our knowledge about renal ENaC function stems from studies in the cortical collecting duct (CCD). Here we investigated ENaC function in the transition zone of DCT2/CNT or CNT/CCD microdissected from mice maintained on different sodium diets to vary plasma aldosterone levels. Single-channel recordings demonstrated amiloride-sensitive Na(+) channels in DCT2/CNT with biophysical properties typical for ENaC previously described in CNT/CCD. In animals maintained on a standard salt diet, the average ENaC-mediated whole cell current ($\Delta$I(ami)) was higher in DCT2/CNT than in CNT/CCD. A low salt diet increased $\Delta$I(ami) in CNT/CCD but had little effect on $\Delta$I(ami) in DCT2/CNT. To investigate whether aldosterone is necessary for ENaC activity in the DCT2/CNT, we used aldosterone synthase knockout (AS(-/-)) mice that lack aldosterone. In CNT/CCD of AS(-/-) mice, $\Delta$I(ami) was lower than that in wild-type (WT) animals and was not stimulated by a low salt diet. In contrast, in DCT2/CNT of AS(-/-) mice, $\Delta$I(ami) was similar to that in DCT2/CNT of WT animals both on a standard and on a low salt diet. We conclude that ENaC function in the DCT2/CNT is largely independent of aldosterone which is in contrast to its known aldosterone sensitivity in CNT/CCD.}}, author = {{Nesterov, Viatcheslav and Dahlmann, Anke and Krueger, Bettina and Bertog, Marko and Loffing, Johannes and Korbmacher, Christoph}}, journal = {{American Journal of Physiology-Renal Physiology}}, number = {{9}}, pages = {{F1289–F1299}}, publisher = {{American Physiological Society}}, title = {{{Aldosterone-dependent and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal nephron}}}, doi = {{10.1152/ajprenal.00247.2012}}, volume = {{303}}, year = {{2012}}, } @article{54939, abstract = {{Background: Renal tubular epithelial cells of proximal and distal origin differ markedly in their physiological functions. Therefore, we hypothesized that they also differ in their capacity to undergo epithelial to mesenchymal alterations. Results: We used cultures of freshly isolated primary human tubular cells. To distinguish cells of different tubular origin we took advantage of the fact that human proximal epithelial cells uniquely express N-cadherin instead of E-cadherin as major cell-cell adhesion molecule. To provoke mesenchymal alteration we treated these cocultures with TGF-$\beta$ for up to 6 days. Within this time period, the morphology of distal tubular cells was barely altered. In contrast to tubular cell lines, E-cadherin was not down-regulated by TGF-$\beta$, even though TGF-$\beta$ signal transduction was initiated as demonstrated by nuclear localization of Smad2/3. Analysis of transcription factors and miRNAs possibly involved in E-cadherin regulation revealed high levels of miRNAs of the miR200-family, which may contribute to the stability of E-cadherin expression in human distal tubular epithelial cells. By contrast, proximal tubular epithelial cells altered their phenotype when treated with TGF-$\beta$. They became elongated and formed three-dimensional structures. Rho-kinases were identified as modulators of TGF-$\beta$-induced morphological alterations. Non-specific inhibition of Rho-kinases resulted in stabilization of the epithelial phenotype, while partial effects were observed upon downregulation of Rho-kinase isoforms ROCK1 and ROCK2. The distinct reactivity of proximal and distal cells was retained when the cells were cultured as polarized cells. Conclusions: Interference with Rho-kinase signaling provides a target to counteract TGF-$\beta$-mediated mesenchymal alterations of epithelial cells, particularly in proximal tubular epithelial cells. Furthermore, primary distal tubular cells differed from cell lines by their high phenotypic stability which included constant expression of E-cadherin. Our cell culture system of primary epithelial cells is thus suitable to understand and modulate cellular remodeling processes of distinct tubular cells relevant for human renal disease.}}, author = {{Keller, Christof and Kroening, Sven and Zuehlke, Jonathan and Kunath, Frank and Krueger, Bettina and Goppelt-Struebe, Margarete}}, issn = {{1932-6203}}, journal = {{PLOS ONE}}, number = {{8}}, pages = {{e43584}}, publisher = {{Public Library of Science}}, title = {{{Distinct Mesenchymal Alterations in N-Cadherin and E-Cadherin Positive Primary Renal Epithelial Cells}}}, doi = {{10.1371/journal.pone.0043584}}, volume = {{7}}, year = {{2012}}, } @article{39724, author = {{Redler, Andreas and Kitzerow, Heinz-Siegfried}}, issn = {{1042-7147}}, journal = {{Polymers for Advanced Technologies}}, keywords = {{Polymers and Plastics}}, number = {{1}}, pages = {{7--9}}, publisher = {{Wiley}}, title = {{{Three-dimensional structure in holographic polymer-dispersed liquid crystals}}}, doi = {{10.1002/pat.3040}}, volume = {{24}}, year = {{2012}}, } @article{40231, author = {{Meier-Gräwe, Uta and Wagenknecht, Inga}}, journal = {{Frühe Kindheit}}, pages = {{24--29}}, publisher = {{Deutsche Liga für das Kind in Familie und Gesellschaft e. V.}}, title = {{{Frühe Hilfen sind eine Zukunftsinvestition}}}, volume = {{14}}, year = {{2012}}, }