@inproceedings{28646, author = {{Pook, Sebastian and Gausemeier, J{\"u}rgen and Dorociak, Rafal}}, title = {{{Securing the reliability of tomorrow's systems with Self-Optimization}}}, year = {{2012}}, } @inproceedings{25810, abstract = {{The analysis of production systems by the use of discrete, event-based simulation is widely used and accepted as decision support method. It aims either at the comparison of competitive designs or the identification of a “best possible” configuration of the simulation model. Here, combinatorial techniques of simulation and optimization methods support the user in finding optimal solutions, which typically result in long computation times and though often prohibit a practical application in today’s industry. This paper presents a fast converging procedure as a combination of a swarm heuristic, namely the particle swarm optimization, and the material flow simulation to close this gap. Faster convergence is realized by a specific extension of classic PSO implementations. First results show the applicability with a simulation reference model. }}, author = {{Laroque, Christoph and Pater, Jan-Patrick}}, isbn = {{978-1-61208-234-9}}, pages = {{50--57}}, title = {{{An Automatic Approach for Parameter Optimization of Material Flow Simulation Models based on Particle Swarm Optimization}}}, year = {{2012}}, } @inproceedings{25811, author = {{Lauck, Sebastian and Hartmann, Philip and Laroque, Christoph}}, pages = {{20--25}}, publisher = {{International Institute of Informatics and Systemics}}, title = {{{Multi-Layer Architecture for Transition of Business-Models to common Software-Tools and Optimization of the Model-Structure exemplified with Microsoft SharePoint 2010}}}, year = {{2012}}, } @inproceedings{25818, author = {{Fischer, Jan-Hendrik and Delius, Robin and Horstkemper, Dennis and Laroque, Christoph}}, title = {{{Comparing a hybrid simulation & optimization approach with a purely stochastic optimization to increase the robustness of production plans}}}, year = {{2012}}, } @article{25821, author = {{Laroque, Christoph and Delius, Robin and Fischer, Jan-Hendrik}}, journal = {{International Journal on Advances in Systems and measurements}}, title = {{{Increase of robustness in production plans using a hybrid optimization and simulation approach}}}, year = {{2012}}, } @article{25820, author = {{Kaganova, Ekaterina}}, journal = {{Applied Mathematical Optimization and Modelling}}, title = {{{Robust solution approach to an uncertain CLSP problem}}}, year = {{2012}}, } @article{25827, abstract = {{Persistent trends like quickly changing production programs, increasing customer individual manufacturing and Sustainable Manufacturing create complex systems of objectives in manufacturing control. Service-oriented manufacturing systems and self-optimizing manufacturing resources offer the required flexibility to consider these objectives in accordance with the current organizational and economical situation. On the downside, this increase in flexibility make the control of manufacturing systems more difficult and presents new challenges regarding the scheduling. To meet these challenges, we developed scheduling framework that supports alternative process plans and considers the internal states trajectories of resources. In order to support the user in a complex decision-making environment, evolutionary multi-objective optimization is used to generate a set of relevant schedules and an interface to select the most appropriate schedule is provided. }}, author = {{Kl{\, Benjamin and Pater, Jan-Patrick and Honiden, Shinichi and Dangelmaier, Wilhelm}}, journal = {{Evolving Systems}}, number = {{1}}, pages = {{31--44}}, title = {{{A multi-objective evolutionary approach to scheduling for evolving manufacturing systems}}}, volume = {{3}}, year = {{2012}}, } @inproceedings{11833, abstract = {{In this paper we propose an approach to retrieve the geometry of an acoustic sensor network consisting of spatially distributed microphone arrays from unconstrained speech input. The calibration relies on Direction of Arrival (DoA) measurements which do not require a clock synchronization among the sensor nodes. The calibration problem is formulated as a cost function optimization task, which minimizes the squared differences between measured and predicted observations and additionally avoids the existence of minima that correspond to mirrored versions of the actual sensor orientations. Further, outlier measurements caused by reverberation are mitigated by a Random Sample Consensus (RANSAC) approach. The experimental results show a mean positioning error of at most 25 cm even in highly reverberant environments.}}, author = {{Jacob, Florian and Schmalenstroeer, Joerg and Haeb-Umbach, Reinhold}}, booktitle = {{International Workshop on Acoustic Signal Enhancement (IWAENC 2012)}}, keywords = {{Unsupervised, geometry calibration, microphone arrays, position self-calibration}}, title = {{{Microphone Array Position Self-Calibration from Reverberant Speech Input}}}, year = {{2012}}, } @inproceedings{46397, abstract = {{In multiobjective optimization, set-based performance indicators are commonly used to assess the quality of a Pareto front approximation. Based on the scalarization obtained by these indicators, a performance comparison of multiobjective optimization algorithms becomes possible. The R2 and the Hypervolume (HV) indicator represent two recommended approaches which have shown a correlated behavior in recent empirical studies. Whereas the HV indicator has been comprehensively analyzed in the last years, almost no studies on the R2 indicator exist. In this paper, we thus perform a comprehensive investigation of the properties of the R2 indicator in a theoretical and empirical way. The influence of the number and distribution of the weight vectors on the optimal distribution of μ solutions is analyzed. Based on a comparative analysis, specific characteristics and differences of the R2 and HV indicator are presented.}}, author = {{Brockhoff, Dimo and Wagner, Tobias and Trautmann, Heike}}, booktitle = {{Proceedings of the 14th Annual Conference on Genetic and Evolutionary Computation}}, isbn = {{9781450311779}}, keywords = {{hypervolume indicator, multiobjective optimization, performance assessment, r2 indicator}}, pages = {{465–472}}, publisher = {{Association for Computing Machinery}}, title = {{{On the Properties of the R2 Indicator}}}, doi = {{10.1145/2330163.2330230}}, year = {{2012}}, } @inproceedings{46396, abstract = {{The steady supply of new optimization methods makes the algorithm selection problem (ASP) an increasingly pressing and challenging task, specially for real-world black-box optimization problems. The introduced approach considers the ASP as a cost-sensitive classification task which is based on Exploratory Landscape Analysis. Low-level features gathered by systematic sampling of the function on the feasible set are used to predict a well-performing algorithm out of a given portfolio. Example-specific label costs are defined by the expected runtime of each candidate algorithm. We use one-sided support vector regression to solve this learning problem. The approach is illustrated by means of the optimization problems and algorithms of the BBOB’09/10 workshop.}}, author = {{Bischl, Bernd and Mersmann, Olaf and Trautmann, Heike and Preuß, Mike}}, booktitle = {{Proceedings of the 14th Annual Conference on Genetic and Evolutionary Computation}}, isbn = {{9781450311779}}, keywords = {{machine learning, exploratory landscape analysis, fitness landscape, benchmarking, evolutionary optimization, bbob test set, algorithm selection}}, pages = {{313–320}}, publisher = {{Association for Computing Machinery}}, title = {{{Algorithm Selection Based on Exploratory Landscape Analysis and Cost-Sensitive Learning}}}, doi = {{10.1145/2330163.2330209}}, year = {{2012}}, } @article{46399, abstract = {{Meta-modeling has become a crucial tool in solving expensive optimization problems. Much of the work in the past has focused on finding a good regression method to model the fitness function. Examples include classical linear regression, splines, neural networks, Kriging and support vector regression. This paper specifically draws attention to the fact that assessing model accuracy is a crucial aspect in the meta-modeling framework. Resampling strategies such as cross-validation, subsampling, bootstrapping, and nested resampling are prominent methods for model validation and are systematically discussed with respect to possible pitfalls, shortcomings, and specific features. A survey of meta-modeling techniques within evolutionary optimization is provided. In addition, practical examples illustrating some of the pitfalls associated with model selection and performance assessment are presented. Finally, recommendations are given for choosing a model validation technique for a particular setting.}}, author = {{Bischl, B and Mersmann, O and Trautmann, Heike and Weihs, C}}, journal = {{Evolutionary Computation Journal}}, number = {{2}}, pages = {{249–275}}, title = {{{Resampling Methods in Model Validation}}}, doi = {{10.1162/EVCO_a_00069}}, volume = {{20}}, year = {{2012}}, } @inproceedings{48890, abstract = {{With this paper we contribute to the understanding of the success of 2-opt based local search algorithms for solving the traveling salesman problem TSP. Although 2-opt is widely used in practice, it is hard to understand its success from a theoretical perspective. We take a statistical approach and examine the features of TSP instances that make the problem either hard or easy to solve. As a measure of problem difficulty for 2-opt we use the approximation ratio that it achieves on a given instance. Our investigations point out important features that make TSP instances hard or easy to be approximated by 2-opt.}}, author = {{Mersmann, Olaf and Bischl, Bernd and Bossek, Jakob and Trautmann, Heike and Wagner, Markus and Neumann, Frank}}, booktitle = {{Revised Selected Papers of the 6th International Conference on Learning and Intelligent Optimization - Volume 7219}}, isbn = {{978-3-642-34412-1}}, keywords = {{2-opt, Classification, Feature Selection, MARS, TSP}}, pages = {{115–129}}, publisher = {{Springer-Verlag}}, title = {{{Local Search and the Traveling Salesman Problem: A Feature-Based Characterization of Problem Hardness}}}, year = {{2012}}, } @inbook{48888, abstract = {{With this paper we contribute to the understanding of the success of 2-opt based local search algorithms for solving the traveling salesman problem (TSP). Although 2-opt is widely used in practice, it is hard to understand its success from a theoretical perspective. We take a statistical approach and examine the features of TSP instances that make the problem either hard or easy to solve. As a measure of problem difficulty for 2-opt we use the approximation ratio that it achieves on a given instance. Our investigations point out important features that make TSP instances hard or easy to be approximated by 2-opt.}}, author = {{Mersmann, Olaf and Bischl, Bernd and Bossek, Jakob and Trautmann, Heike and Wagner, Markus and Neumann, Frank}}, booktitle = {{Learning and Intelligent Optimization}}, isbn = {{978-3-642-34412-1 978-3-642-34413-8}}, pages = {{115–129}}, publisher = {{Springer Berlin Heidelberg}}, title = {{{Local Search and the Traveling Salesman Problem: A Feature-Based Characterization of Problem Hardness}}}, doi = {{10.1007/978-3-642-34413-8_9}}, volume = {{7219}}, year = {{2012}}, } @inbook{49699, author = {{Jacke, Christoph}}, booktitle = {{GLEIS 22 - Fünfundzwanzig Jahre Konzerte.}}, editor = {{Skroblin, David and Dietrich, Frank}}, pages = {{6--8}}, publisher = {{Oktober Verlag}}, title = {{{Der Club „Gleis 22". 25 Jahre andere Räume, andere Musiken, Kommunikation und Kreativität.}}}, year = {{2012}}, } @inproceedings{46398, abstract = {{With this paper we contribute to the understanding of the success of 2-opt based local search algorithms for solving the traveling salesman problem (TSP). Although 2-opt is widely used in practice, it is hard to understand its success from a theoretical perspective. We take a statistical approach and examine the features of TSP instances that make the problem either hard or easy to solve. As a measure of problem difficulty for 2-opt we use the approximation ratio that it achieves on a given instance. Our investigations point out important features that make TSP instances hard or easy to be approximated by 2-opt.}}, author = {{Mersmann, Olaf and Bischl, Bernd and Bossek, Jakob and Trautmann, Heike and Wagner, Markus and Neumann, Frank}}, booktitle = {{Learning and Intelligent Optimization}}, editor = {{Hamadi, Youssef and Schoenauer, Marc}}, isbn = {{978-3-642-34413-8}}, pages = {{115–129}}, publisher = {{Springer Berlin Heidelberg}}, title = {{{Local Search and the Traveling Salesman Problem: A Feature-Based Characterization of Problem Hardness}}}, doi = {{https://doi.org/10.1007/978-3-642-34413-8_9}}, year = {{2012}}, } @article{54937, abstract = {{Purpose: The epithelial sodium channel (ENaC) is typically expressed in sodium-absorbing epithelia. Several reports suggest that ENaC is also expressed in ocular tissues and may play a role in aqueous humor secretion and glaucoma. However, the precise localization of ENaC in the human eye is still unclear. Here, the authors studied ENaC expression in 12 normal human donor eyes and in six eyes of patients with glaucoma. Methods: Quantitative real-time PCR was used to investigate the expression of $\alpha$-, $\beta$-, $\gamma$-, and $\delta$-ENaC transcripts in ocular tissues. In addition, the authors performed immunohistochemical studies using recently generated antibodies against human $\beta$- and $\gamma$-ENaC. Results: At the mRNA level, all four ENaC subunits were found to be expressed in a wide range of ocular tissues from normal and glaucomatous human eyes, with the cornea, ciliary body, iris, and retina showing the highest expression levels. At the protein level, $\beta$- and $\gamma$-ENaC subunits showed distinct distribution patterns and could be immunolocalized primarily to the cell membranes of epithelial cells of the cornea and to the conjunctiva, iris, ciliary body, lens, and retinal pigment epithelium but also to vascular endothelial cells, smooth muscle cells, stromal cells, and retinal neurons. The authors found no altered mRNA level of any subunit in glaucomatous eyes. Conclusions: All four ENaC subunits ($\alpha$$\beta$$\gamma$$\delta$) are expressed in the normal human eye, with distinct localization of subunits possibly reflecting different functional states of the channel. The (patho-)physiological roles of ENaC in the various localizations in the eye remain to be determined.}}, author = {{Krueger, Bettina and Schlötzer-Schrehardt, Ursula and Haerteis, Silke and Zenkel, Matthias and Chankiewitz, Verena E. and Amann, Kerstin U. and Kruse, Friedrich E. and Korbmacher, Christoph}}, journal = {{Investigative Opthalmology & Visual Science}}, number = {{2}}, pages = {{596–604}}, publisher = {{Association for Research in Vision and Ophthalmology (ARVO)}}, title = {{{Four Subunits ($\alpha$$\beta$$\gamma$$\delta$) of the Epithelial Sodium Channel (ENaC) Are Expressed in the Human Eye in Various Locations}}}, doi = {{10.1167/iovs.11-8581}}, volume = {{53}}, year = {{2012}}, } @article{54930, abstract = {{Background: Increased expression of the pro-fibrotic protein connective tissue growth factor (CTGF) has been detected in injured kidneys and elevated urinary levels of CTGF are discussed as prognostic marker of chronic kidney disease. There is evidence that epithelial cells lining the renal tubular system contribute to uptake and secretion of CTGF. However, the role of different types of tubular epithelial cells in these processes so far has not been addressed in primary cultures of human cells. Results: Tubular epithelial cells of proximal and distal origin were isolated from human kidneys and cultured as polarized cells in insert wells. The pro-fibrotic stimuli lysophosphatidic acid (LPA) and transforming growth factor $\beta$ (TGF-$\beta$) were used to induce CTGF secretion.LPA activated CTGF secretion in proximal tubular cells when applied from either the apical or the basolateral side as shown by immunocytochemistry. CTGF was secreted exclusively to the apical side. Signaling pathways activated by LPA included MAP kinase and Rho kinase signaling. TGF-$\beta$ applied from either side also stimulated CTGF secretion primarily to the apical side with little basolateral release.Interestingly, TGF-$\beta$ activation induced different signaling pathways depending on the side of TGF-$\beta$ application. Smad signaling was almost exclusively activated from the basolateral side most prominently in cells of distal origin. Only part of these cells also synthesized CTGF indicating that Smad activation alone was not sufficient for CTGF induction. MAP kinases were involved in apical TGF-$\beta$-mediated activation of CTGF synthesis in proximal cells and a subset of epithelial cells of distal origin. This subpopulation of distal tubular cells was also able to internalize recombinant apical CTGF, in addition to proximal cells which were the main cells to take up exogenous CTGF. Conclusions: Analysis of polarized human primary renal epithelial cells in a transwell system shows that vectorial secretion of the pro-fibrotic protein CTGF depends on the cell type, the stimulus and the signaling pathway activated. In all conditions, CTGF was secreted mainly to the apical side upon TGF-$\beta$ and LPA treatment and therefore, likely contributes to increased urinary CTGF levels in vivo. Moreover, CTGF secreted basolaterally may be active as paracrine pro-fibrotic mediator.}}, author = {{Zuehlke, Jonathan and Ebenau, Astrid and Krueger, Bettina and Goppelt-Struebe, Margarete}}, journal = {{Cell Communication and Signaling}}, number = {{1}}, publisher = {{Springer}}, title = {{{Vectorial secretion of CTGF as a cell-type specific response to LPA and TGF-$\beta$ in human tubular epithelial cells}}}, doi = {{10.1186/1478-811x-10-25}}, volume = {{10}}, year = {{2012}}, } @article{54934, abstract = {{Aldosterone is thought to be the main hormone to stimulate the epithelial sodium channel (ENaC) in the aldosterone-sensitive distal nephron (ASDN) comprising the late distal convoluted tubule (DCT2), the connecting tubule (CNT) and the entire collecting duct (CD). There is immunohistochemical evidence for an axial gradient of ENaC expression along the ASDN with highest expression in the DCT2 and CNT. However, most of our knowledge about renal ENaC function stems from studies in the cortical collecting duct (CCD). Here we investigated ENaC function in the transition zone of DCT2/CNT or CNT/CCD microdissected from mice maintained on different sodium diets to vary plasma aldosterone levels. Single-channel recordings demonstrated amiloride-sensitive Na(+) channels in DCT2/CNT with biophysical properties typical for ENaC previously described in CNT/CCD. In animals maintained on a standard salt diet, the average ENaC-mediated whole cell current ($\Delta$I(ami)) was higher in DCT2/CNT than in CNT/CCD. A low salt diet increased $\Delta$I(ami) in CNT/CCD but had little effect on $\Delta$I(ami) in DCT2/CNT. To investigate whether aldosterone is necessary for ENaC activity in the DCT2/CNT, we used aldosterone synthase knockout (AS(-/-)) mice that lack aldosterone. In CNT/CCD of AS(-/-) mice, $\Delta$I(ami) was lower than that in wild-type (WT) animals and was not stimulated by a low salt diet. In contrast, in DCT2/CNT of AS(-/-) mice, $\Delta$I(ami) was similar to that in DCT2/CNT of WT animals both on a standard and on a low salt diet. We conclude that ENaC function in the DCT2/CNT is largely independent of aldosterone which is in contrast to its known aldosterone sensitivity in CNT/CCD.}}, author = {{Nesterov, Viatcheslav and Dahlmann, Anke and Krueger, Bettina and Bertog, Marko and Loffing, Johannes and Korbmacher, Christoph}}, journal = {{American Journal of Physiology-Renal Physiology}}, number = {{9}}, pages = {{F1289–F1299}}, publisher = {{American Physiological Society}}, title = {{{Aldosterone-dependent and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal nephron}}}, doi = {{10.1152/ajprenal.00247.2012}}, volume = {{303}}, year = {{2012}}, } @article{54939, abstract = {{Background: Renal tubular epithelial cells of proximal and distal origin differ markedly in their physiological functions. Therefore, we hypothesized that they also differ in their capacity to undergo epithelial to mesenchymal alterations. Results: We used cultures of freshly isolated primary human tubular cells. To distinguish cells of different tubular origin we took advantage of the fact that human proximal epithelial cells uniquely express N-cadherin instead of E-cadherin as major cell-cell adhesion molecule. To provoke mesenchymal alteration we treated these cocultures with TGF-$\beta$ for up to 6 days. Within this time period, the morphology of distal tubular cells was barely altered. In contrast to tubular cell lines, E-cadherin was not down-regulated by TGF-$\beta$, even though TGF-$\beta$ signal transduction was initiated as demonstrated by nuclear localization of Smad2/3. Analysis of transcription factors and miRNAs possibly involved in E-cadherin regulation revealed high levels of miRNAs of the miR200-family, which may contribute to the stability of E-cadherin expression in human distal tubular epithelial cells. By contrast, proximal tubular epithelial cells altered their phenotype when treated with TGF-$\beta$. They became elongated and formed three-dimensional structures. Rho-kinases were identified as modulators of TGF-$\beta$-induced morphological alterations. Non-specific inhibition of Rho-kinases resulted in stabilization of the epithelial phenotype, while partial effects were observed upon downregulation of Rho-kinase isoforms ROCK1 and ROCK2. The distinct reactivity of proximal and distal cells was retained when the cells were cultured as polarized cells. Conclusions: Interference with Rho-kinase signaling provides a target to counteract TGF-$\beta$-mediated mesenchymal alterations of epithelial cells, particularly in proximal tubular epithelial cells. Furthermore, primary distal tubular cells differed from cell lines by their high phenotypic stability which included constant expression of E-cadherin. Our cell culture system of primary epithelial cells is thus suitable to understand and modulate cellular remodeling processes of distinct tubular cells relevant for human renal disease.}}, author = {{Keller, Christof and Kroening, Sven and Zuehlke, Jonathan and Kunath, Frank and Krueger, Bettina and Goppelt-Struebe, Margarete}}, issn = {{1932-6203}}, journal = {{PLOS ONE}}, number = {{8}}, pages = {{e43584}}, publisher = {{Public Library of Science}}, title = {{{Distinct Mesenchymal Alterations in N-Cadherin and E-Cadherin Positive Primary Renal Epithelial Cells}}}, doi = {{10.1371/journal.pone.0043584}}, volume = {{7}}, year = {{2012}}, } @article{39724, author = {{Redler, Andreas and Kitzerow, Heinz-Siegfried}}, issn = {{1042-7147}}, journal = {{Polymers for Advanced Technologies}}, keywords = {{Polymers and Plastics}}, number = {{1}}, pages = {{7--9}}, publisher = {{Wiley}}, title = {{{Three-dimensional structure in holographic polymer-dispersed liquid crystals}}}, doi = {{10.1002/pat.3040}}, volume = {{24}}, year = {{2012}}, }