@article{46417,
  abstract     = {{ In this article a method for including a priori preferences of decision makers into multicriteria optimization problems is presented. A set of Pareto-optimal solutions is determined via desirability functions of the objectives which reveal experts’ preferences regarding different objective regions. An application to noisy objective functions is not straightforward but very relevant for practical applications. Two approaches are introduced in order to handle the respective uncertainties by means of the proposed preference-based Pareto optimization. By applying the methods to the original and uncertain Binh problem and a noisy single cut turning cost optimization problem, these approaches prove to be very effective in focusing on different parts of the Pareto front of the ori-ginal problem in both certain and noisy environments. }},
  author       = {{Trautmann, Heike and Mehnen, Jörn}},
  journal      = {{Engineering Optimization}},
  number       = {{1}},
  pages        = {{23--38}},
  publisher    = {{Taylor & Francis}},
  title        = {{{Preference-based Pareto optimization in certain and noisy environments}}},
  doi          = {{10.1080/03052150802347926}},
  volume       = {{41}},
  year         = {{2009}},
}

@article{54931,
  abstract     = {{Proteinuria and increased renal reabsorption of NaCl characterize the nephrotic syndrome. Here, we show that protein-rich urine from nephrotic rats and from patients with nephrotic syndrome activate the epithelial sodium channel (ENaC) in cultured M-1 mouse collecting duct cells and in Xenopus laevis oocytes heterologously expressing ENaC. The activation depended on urinary serine protease activity. We identified plasmin as a urinary serine protease by matrix-assisted laser desorption/ionization time of-flight mass spectrometry. Purified plasmin activated ENaC currents, and inhibitors of plasmin abolished urinary protease activity and the ability to activate ENaC. In nephrotic syndrome, tubular urokinase-type plasminogen activator likely converts filtered plasminogen to plasmin. Consistent with this, the combined application of urokinase-type plasminogen activator and plasminogen stimulated amiloride-sensitive transepithelial sodium transport in M-1 cells and increased amiloride-sensitive whole-cell currents in Xenopus laevis oocytes heterologously expressing ENaC. Activation of ENaC by plasmin involved cleavage and release of an inhibitory peptide from the ENaC gamma subunit ectodomain. These data suggest that a defective glomerular filtration barrier allows passage of proteolytic enzymes that have the ability to activate ENaC.}},
  author       = {{Svenningsen, Per and Bistrup, Claus and Friis, Ulla G. and Bertog, Marko and Haerteis, Silke and Krueger, Bettina and Stubbe, Jane and Jensen, Ole Nørregaard and Thiesson, Helle C. and Uhrenholt, Torben R. and Jespersen, Bente and Jensen, Boye L. and Korbmacher, Christoph and Skøtt, Ole}},
  journal      = {{Journal of the American Society of Nephrology}},
  number       = {{2}},
  pages        = {{299–310}},
  publisher    = {{Ovid Technologies (Wolters Kluwer Health)}},
  title        = {{{Plasmin in Nephrotic Urine Activates the Epithelial Sodium Channel}}},
  doi          = {{10.1681/asn.2008040364}},
  volume       = {{20}},
  year         = {{2009}},
}

@article{54932,
  abstract     = {{Incubation of microvascular endothelial cells with combretastatin A-4 phosphate (CA-4P), a microtubule-destabilizing compound that preferentially targets tumor vessels, altered cell morphology and induced scattering of Golgi stacks. Concomitantly, CA-4P up-regulated connective tissue growth factor (CTGF/CCN2), a pleiotropic factor with antiangiogenic properties. In contrast to the effects of other microtubule-targeting agents such as colchicine or nocodazole, up-regulation of CTGF was only detectable in sparse cells, which were not embedded in a cell monolayer. Furthermore, CA-4P induced CTGF expression in endothelial cells, forming tube-like structures on basement membrane gels. Up-regulation of CTGF by CA-4P was dependent on Rho kinase signaling and was increased when p42/44 mitogen-activated protein kinase was inhibited. Additionally, FoxO transcription factors were identified as potent regulators of CTGF expression in endothelial cells. Activation of FoxO transcription factors by inhibition of phosphatidylinositol 3-kinase/AKT signaling resulted in a synergistic increase in CA-4P-mediated CTGF induction. CA-4P-mediated expression of CTGF was thus potentiated by the inhibition of kinase pathways, which are targets of novel antineoplastic drugs. Up-regulation of CTGF by low concentrations of CA-4P may thus occur in newly formed tumor vessels and contribute to the microvessel destabilization and antiangiogenic effects of CA-4P observed in vivo.}},
  author       = {{Samarin, Jana and Rehm, Margot and Krueger, Bettina and Waschke, Jens and Goppelt-Struebe, Margarete}},
  journal      = {{Molecular Cancer Research}},
  number       = {{2}},
  pages        = {{180–188}},
  publisher    = {{American Association for Cancer Research (AACR)}},
  title        = {{{Up-Regulation of Connective Tissue Growth Factor in Endothelial Cells by the Microtubule-Destabilizing Agent Combretastatin A-4}}},
  doi          = {{10.1158/1541-7786.mcr-08-0292}},
  volume       = {{7}},
  year         = {{2009}},
}

@article{54944,
  abstract     = {{The epithelial sodium channel (ENaC) is probably a heterotrimer with three well characterized subunits (alphabetagamma). In humans an additional delta-subunit (delta-hENaC) exists but little is known about its function. Using the Xenopus laevis oocyte expression system, we compared the functional properties of alphabetagamma- and deltabetagamma-hENaC and investigated whether deltabetagamma-hENaC can be proteolytically activated. The amiloride-sensitive ENaC whole-cell current (DeltaI(ami)) was about 11-fold larger in oocytes expressing deltabetagamma-hENaC than in oocytes expressing alphabetagamma-hENaC. The 2-fold larger single-channel Na(+) conductance of deltabetagamma-hENaC cannot explain this difference. Using a chemiluminescence assay, we demonstrated that an increased channel surface expression is also not the cause. Thus, overall channel activity of deltabetagamma-hENaC must be higher than that of alphabetagamma-hENaC. Experiments exploiting the properties of the known betaS520C mutant ENaC confirmed this conclusion. Moreover, chymotrypsin had a reduced stimulatory effect on deltabetagamma-hENaC whole-cell currents compared with its effect on alphabetagamma-hENaC whole-cell currents (2-fold versus 5-fold). This suggests that the cell surface pool of so-called near-silent channels that can be proteolytically activated is smaller for deltabetagamma-hENaC than for alphabetagamma-hENaC. Proteolytic activation of deltabetagamma-hENaC was associated with the appearance of a delta-hENaC cleavage product at the cell surface. Finally, we demonstrated that a short inhibitory 13-mer peptide corresponding to a region of the extracellular loop of human alpha-ENaC inhibited DeltaI(ami) in oocytes expressing alphabetagamma-hENaC but not in those expressing deltabetagamma-hENaC. We conclude that the delta-subunit of ENaC alters proteolytic channel activation and enhances base-line channel activity.}},
  author       = {{Haerteis, Silke and Krueger, Bettina and Korbmacher, Christoph and Rauh, Robert}},
  journal      = {{Journal of Biological Chemistry}},
  number       = {{42}},
  pages        = {{29024–29040}},
  publisher    = {{American Society for Biochemistry and Molecular Biology}},
  title        = {{{The $\delta$-Subunit of the Epithelial Sodium Channel (ENaC) Enhances Channel Activity and Alters Proteolytic ENaC Activation}}},
  doi          = {{10.1074/jbc.m109.018945}},
  volume       = {{284}},
  year         = {{2009}},
}

@article{54938,
  abstract     = {{The lipid environment of the epithelial sodium channel (ENaC) and its possible association with so-called lipid rafts may be relevant to its function. The aim of our study was to confirm the association of ENaC with lipid rafts and to analyze the effect of cholesterol depletion of the plasma membrane by methyl-beta-cyclodextrin (MbetaCD) on channel function and regulation. Using sucrose density gradient centrifugation we demonstrated that a significant portion of ENaC protein distributes to low density fractions thought to be typical lipid raft fractions. Importantly, cholesterol depletion of cell lysate by MbetaCD shifted ENaC to non-raft fractions of higher density. Live cell imaging demonstrated that treatment with MbetaCD largely reduced filipin staining over time, confirming cholesterol depletion of the plasma membrane. For electrophysiological studies intact oocytes were exposed to 20 mM MbetaCD for three hours. MbetaCD treatment had no consistent effect on baseline whole-cell ENaC currents. In addition to the typical single channel conductance of about 5 pS, subconductance states of ENaC were occasionally observed in patches from MbetaCD treated but not from control oocytes. Importantly, in outside-out patch clamp recordings the stimulatory effect of recombinant SGK1 in the pipette solution was essentially abolished in oocytes pretreated with MbetaCD. These results indicate that ENaC activation by cytosolic SGK1 is compromised by removing cholesterol from the plasma membrane. Thus, ENaC activation by SGK1 may require the presence of an intact lipid environment and/or of lipid rafts as signalling platform.}},
  author       = {{Krueger, Bettina and Haerteis, Silke and Yang, Limin and Hartner, Andrea and Rauh, Robert and Korbmacher, Christoph and Diakov, Alexei}},
  journal      = {{Cellular Physiology and Biochemistry}},
  number       = {{5-6}},
  pages        = {{605–618}},
  publisher    = {{S. Karger AG}},
  title        = {{{Cholesterol Depletion of the Plasma Membrane Prevents Activation of the Epithelial Sodium Channel (ENaC) by SGK1}}},
  doi          = {{10.1159/000257516}},
  volume       = {{24}},
  year         = {{2009}},
}

@article{54945,
  abstract     = {{We describe a programming scheme for massively distributed systems that are assumed to self-organize according to a given set of simple rules. The focus of this investigation is operation and control in Sensor and Actor Networks (SANETs). The main issues addressed by self-organization techniques are scalability, network lifetime, and real-time support. In the literature, biological principles are often cited as inspirations for technical solutions, especially in the domain of self-organization. We developed a system named Rule-based Sensor Network (RSN) according to the observed communication and control behavior in cellular communication. Cellular signaling cascades allow the event-specific reaction initiated by individual cells in collaboration with their direct neighbors. Information between cells are transmitted via proteins and result in the cascade of protein-protein or protein-DNA interactions to produce a specific cellular answer, e.g. the activation of cells or the transmission of mediators. These processes are programmed in every individual cell and lead to a coordinated reaction on a higher organization platform. We transferred these mechanisms to operation and control in SANETs. In particular, a rule-based processing scheme relying on the main concepts of cellular signaling cascades has been developed. It relies on simple local rules and provides problem specific reaction such as local actuation control and data manipulation. We describe this RSN technology and demonstrate comparative simulation results that show the feasibility of our approach.}},
  author       = {{Dressler, Falko and Dietrich, Isabel and German, Reinhard and Krueger, Bettina}},
  issn         = {{1389-1286}},
  journal      = {{Elsevier Computer Networks}},
  number       = {{10}},
  pages        = {{1737–1750}},
  publisher    = {{Elsevier}},
  title        = {{{A Rule-based System for Programming Self-Organized Sensor and Actor Networks}}},
  doi          = {{10.1016/j.comnet.2008.09.007}},
  volume       = {{53}},
  year         = {{2009}},
}

@article{36050,
  author       = {{Schlegel-Matthies, Kirsten and Methfessel, Barbara and Bigga, Regine}},
  issn         = {{0342-5088}},
  journal      = {{Haushalt & Bildung}},
  number       = {{2}},
  pages        = {{10--14}},
  publisher    = {{Schneider-Verlag}},
  title        = {{{Materielle Ressourcen – oder: Warum, wozu und wie haben und nutzen wir Güter?}}},
  volume       = {{86}},
  year         = {{2009}},
}

@article{40220,
  author       = {{Wagenknecht, Inga and Meier-Gräwe, Uta and Fegert, Jörg M.}},
  issn         = {{0721-9121}},
  journal      = {{Frühförderung interdisziplinär}},
  pages        = {{82--91}},
  title        = {{{Frühe Hilfen rechnen sich}}},
  volume       = {{28}},
  year         = {{2009}},
}

@inproceedings{44069,
  abstract     = {{Recently it has been shown experimentally that it is possible to coherently control nano-optical excitations by using sophisticated shaped laser pulses. In this work a similar technique is used to theoretically investigate a hybrid nanostructure which consists of a metal aperture and a quantum wire. It is shown that one can concentrate the optically excited electron density at an arbitrary position due to wave packet dynamics by chosing particular frequency components and phases of the chirped laser pulse. The optimization process is performed with a genetic algorithm which is linked to a 3D-FDTD solver.}},
  author       = {{Meier, Torsten and Reichelt, Matthias}},
  booktitle    = {{DPG Spring meeting 2009}},
  issn         = {{0420-0195}},
  location     = {{Dresden, Germany}},
  number       = {{5}},
  title        = {{{Coherent control in hybrid metal-semiconductor nanostructures}}},
  volume       = {{44}},
  year         = {{2009}},
}

@inproceedings{2350,
  abstract     = {{Mapping applications that consist of a collection of cores to FPGA accelerators and optimizing their performance is a challenging task in high performance reconfigurable computing. We present IMORC, an architectural template and highly versatile on-chip interconnect. IMORC links provide asynchronous FIFOs and bitwidth conversion which allows for flexibly composing accelerators from cores running at full speed within their own clock domains, thus facilitating the re-use of cores and portability. Further, IMORC inserts performance counters for monitoring runtime data. In this paper, we first introduce the IMORC architectural template and the on-chip interconnect, and then demonstrate IMORC on the example of accelerating the k-th nearest neighbor thinning problem on an XD1000 reconfigurable computing system. Using IMORC's monitoring infrastructure, we gain insights into the data-dependent behavior of the application which, in turn, allow for optimizing the accelerator. }},
  author       = {{Schumacher, Tobias and Plessl, Christian and Platzner, Marco}},
  booktitle    = {{Proc. Int. Symp. on Field-Programmable Custom Computing Machines (FCCM)}},
  isbn         = {{978-1-4244-4450-2}},
  keywords     = {{IMORC, interconnect, performance}},
  pages        = {{275--278}},
  publisher    = {{IEEE Computer Society}},
  title        = {{{IMORC: Application Mapping, Monitoring and Optimization for High-Performance Reconfigurable Computing}}},
  doi          = {{10.1109/FCCM.2009.25}},
  year         = {{2009}},
}

@inproceedings{2262,
  abstract     = {{In this work we present EvoCache, a novel approach for implementing application-specific caches. The key innovation of EvoCache is to make the function that maps memory addresses from the CPU address space to cache indices programmable. We support arbitrary Boolean mapping functions that are implemented within a small reconfigurable logic fabric. For finding suitable cache mapping functions we rely on techniques from the evolvable hardware domain and utilize an evolutionary optimization procedure. We evaluate the use of EvoCache in an embedded processor for two specific applications (JPEG and BZIP2 compression) with respect to execution time, cache miss rate and energy consumption. We show that the evolvable hardware approach for optimizing the cache functions not only significantly improves the cache performance for the training data used during optimization, but that the evolved mapping functions generalize very well. Compared to a conventional cache architecture, EvoCache applied to test data achieves a reduction in execution time of up to 14.31% for JPEG (10.98% for BZIP2), and in energy consumption by 16.43% for JPEG (10.70% for BZIP2). We also discuss the integration of EvoCache into the operating system and show that the area and delay overheads introduced by EvoCache are acceptable. }},
  author       = {{Kaufmann, Paul and Plessl, Christian and Platzner, Marco}},
  booktitle    = {{Proc. NASA/ESA Conference on Adaptive Hardware and Systems (AHS)}},
  keywords     = {{EvoCache, evolvable hardware, computer architecture}},
  pages        = {{11--18}},
  publisher    = {{IEEE Computer Society}},
  title        = {{{EvoCaches: Application-specific Adaptation of Cache Mapping}}},
  year         = {{2009}},
}

@article{64055,
  abstract     = {{A program for iterative fitting procedures to determine the NMR parameters from 51V solid-state MAS NMR spectra was developed. It contains options to use genetic algorithms and downhill-simplex optimizing procedures to extract the optimal parameter sets, which describe our spectra. As computational kernel the SIMPSON program is employed. Other kernels like SPINEVOLUTION are easily incorporable. The algorithms are checked for their suitability for the present optimization problem and optimal simulation conditions are determined, with the focus on minimal processing time. The procedure leads to a very good agreement between experimental and simulated spectra in a passable period of time. First results for spectra of model compounds for the active site of vanadium haloperoxidases are presented.}},
  author       = {{Waechtler, Maria and Schweitzer, Annika and Gutmann, Torsten and Breitzke, Hergen and Buntkowsky, Gerd}},
  journal      = {{Solid State Nuclear Magnetic Resonance}},
  keywords     = {{51V MAS NMR spectroscopy, Genetic algorithms, Iterative fitting procedures, Model complexes for vanadium haloperoxidases}},
  number       = {{1}},
  pages        = {{37–48}},
  title        = {{{Efficient analysis of 51V solid-state MAS NMR spectra using genetic algorithms}}},
  doi          = {{10.1016/j.ssnmr.2008.11.003}},
  volume       = {{35}},
  year         = {{2009}},
}

@inproceedings{19813,
  abstract     = {{Autonomous robotic systems have been gaining the attention of research community in mobile ad hoc network since the past few years. While motion cost and communications cost constitute the primary energy consumers, each of them is investigated independently. By taking into account the power consumption of both entities, the overall energy efficiency of a system can be further improved. In this paper, the energy optimization problem of radio communication and motion is examined. We consider a hybrid wireless  network that consists of a single autonomous mobile node and multiple relay nodes. The mobile node interacts with the relays within its vicinity by continuously communicating high-bandwidth data, e.g. triggered by a multimedia application like video surveillance. The goal is to find the best path such that the energy consumption for both mobility and communications is minimized. We introduce the Radio-Energy-Aware (REA) path computation strategy by utilizing node mobility. Given the starting point, the target point and the position of the relays, our simulation results show that the proposed strategy improves the energy efficiency of mobile node compared to the Motion-Energy-Aware (MEA) path constructed based only on the mobility cost. }},
  author       = {{Ooi, Chia Ching and Schindelhauer, Christian}},
  booktitle    = {{MWCN'08: Proc. of IFIP Joint Conference on Mobile Wireless Communications Networks (MWCN 2008) and Personal Wireless Communications (PWC 2008)}},
  isbn         = {{9780387848389}},
  issn         = {{1571-5736}},
  publisher    = {{Springer}},
  title        = {{{Detours Save Energy in Mobile Wireless Networks}}},
  doi          = {{10.1007/978-0-387-84839-6_6}},
  year         = {{2008}},
}

@book{25839,
  author       = {{Parisi, Salvatore}},
  publisher    = {{Verlagsschriftenreihe des Heinz Nixdorf Instituts, Paderborn}},
  title        = {{{A Method for the intelligent Authoring of 3D Animations for Traimimg and Maintenance}}},
  volume       = {{228}},
  year         = {{2008}},
}

@article{25938,
  author       = {{Karaolis-Danckert, N and Buyken, Anette and Kulig, M and Kroke, A and Forster, J and Kamin, W and Schuster, A and Hornberg, C and Keil, T and Bergmann, RL and Wahn, U and Lau, S}},
  issn         = {{0002-9165}},
  journal      = {{Am J Clin Nutr}},
  number       = {{5}},
  pages        = {{1356--1364}},
  title        = {{{How pre- and postnatal risk factors modify the effect of rapid weight gain in infancy and early childhood on subsequent fat mass development: results from the Multicenter Allergy Study 90.}}},
  doi          = {{10.1093/ajcn/87.5.1356}},
  volume       = {{87}},
  year         = {{2008}},
}

@article{26891,
  author       = {{Buyken, Anette and Karaolis-Danckert, Nadina and Remer, Thomas}},
  issn         = {{0002-9165}},
  journal      = {{The American Journal of Clinical Nutrition}},
  pages        = {{221--230}},
  title        = {{{Association of prepubertal body composition in healthy girls and boys with the timing of early and late pubertal markers}}},
  doi          = {{10.3945/ajcn.2008.26733}},
  year         = {{2008}},
}

@article{26892,
  author       = {{Libuda, Lars and Alexy, Ute and Buyken, Anette and Sichert-Hellert, Wolfgang and Stehle, Peter and Kersting, Mathilde}},
  issn         = {{0007-1145}},
  journal      = {{British Journal of Nutrition}},
  title        = {{{Consumption of sugar-sweetened beverages and its association with nutrient intakes and diet quality in German children and adolescents}}},
  doi          = {{10.1017/s0007114508094671}},
  year         = {{2008}},
}

@article{27137,
  author       = {{Libuda, Lars and Alexy, Ute and Remer, Thomas and Stehle, Peter and Schoenau, Eckhard and Kersting, Mathilde}},
  issn         = {{0002-9165}},
  journal      = {{The American Journal of Clinical Nutrition}},
  pages        = {{1670--1677}},
  title        = {{{Association between long-term consumption of soft drinks and variables of bone modeling and remodeling in a sample of healthy German children and adolescents}}},
  doi          = {{10.3945/ajcn.2008.26414}},
  year         = {{2008}},
}

@article{27586,
  author       = {{Libuda, Lars and Alexey, U. and Stehle, P. and Kersting, M.}},
  journal      = {{Aktuelle Ernährungsmedizin}},
  pages        = {{123--131}},
  title        = {{{Konsum von Erfrischungsgetränken und Entwicklung des Körpergewichts im Kindes- und Jugendalter – Gibt es eine Verbindung? }}},
  doi          = {{10.1055/s-2007-986311}},
  volume       = {{33}},
  year         = {{2008}},
}

@article{27587,
  author       = {{Libuda, Lars and Kersting, M.}},
  journal      = {{Ernährungsumschau}},
  pages        = {{646}},
  title        = {{{DONALD News: Erfrischungsgetränke und Ernährungsqualität. }}},
  volume       = {{55}},
  year         = {{2008}},
}