@article{26420,
  author       = {{Hirtz, Raphael and Focker, Manuel and Libuda, Lars and Antel, Jochen and Ozturk, Dana and Kiewert, Cordula and Munteanu, Martin and Peters, Triinu and Fuhrer, Dagmar and Zwanziger, Denise and Thamm, Michael and Hebebrand, Johannes and Grasemann, Corinna}},
  issn         = {{1555-2101}},
  journal      = {{The Journal of Clinical Psychiatry}},
  title        = {{{Increased Prevalence of Subclinical Hypothyroidism and Thyroid Autoimmunity in Depressed Adolescents}}},
  doi          = {{10.4088/jcp.20m13511}},
  year         = {{2021}},
}

@article{26523,
  abstract     = {{<jats:title>Abstract</jats:title><jats:p>With this case report we support our medical hypothesis that metreleptin treatment ameliorates starvation related emotional, cognitive and behavioral symptomatology of anorexia nervosa (AN) and show for the first time strong effects in a male patient with AN. A 15.9 year old adolescent with severe AN of eight-month duration was treated off-label with metreleptin. Hyperactivity was assessed with accelerometry. Visual analogue scales (VAS), validated self- and clinician rating scales and lab results tracked changes from baseline to end of the 24-day dosing period and a five-month follow-up. Substantial improvements of mood and eating disorder related cognitions and hyperactivity set in after two days of treatment. During dosing, sub-physiological testosterone and TT3 levels normalized; clinically libido reemerged. Weight did not increase substantially during the dosing period. During follow-up target weight was attained; mood did not deteriorate; hyperactivity ceased. The results substantiate the strong effects seen in female cases and underscore the need for a double-blind placebo-controlled trial to confirm the observed strong, multiple and rapid onset beneficial effects of metreleptin in AN.</jats:p>}},
  author       = {{Antel, Jochen and Tan, Susanne and Grabler, Marvin and Ludwig, Christine and Lohkemper, Dominik and Brandenburg, Tim and Barth, Nikolaus and Hinney, Anke and Libuda, Lars and Remy, Miriam and Milos, Gabriella and Hebebrand, Johannes}},
  issn         = {{1018-8827}},
  journal      = {{European Child & Adolescent Psychiatry}},
  title        = {{{Rapid amelioration of anorexia nervosa in a male adolescent during metreleptin treatment including recovery from hypogonadotropic hypogonadism}}},
  doi          = {{10.1007/s00787-021-01778-7}},
  year         = {{2021}},
}

@inbook{26633,
  author       = {{Schlegel-Matthies, Kirsten and Wespi, Claudia}},
  booktitle    = {{Wirksamer Fachunterricht. Eine metaanalytische Betrachtung von Expertisen aus 17 Schulfächern}},
  editor       = {{Reinhardt, V. and Rehm , M. and Wilhem , M.}},
  pages        = {{200--217}},
  publisher    = {{Baltmannsweiler: Schneider-Verlag}},
  title        = {{{Befähigung zur Reflexion und zum Umgang mit Ambiguitäten. Zur Wirksamkeit von Unterricht für "Lebensführung"}}},
  year         = {{2021}},
}

@book{26635,
  author       = {{Schlegel-Matthies, Kirsten and Wespi, Claudia}},
  isbn         = {{ISBN-13: 9783834020314}},
  pages        = {{245}},
  publisher    = {{Baltmannsweiler: Schneider-Verlag.}},
  title        = {{{Wirksamer Unterricht für Lebensführung. (Unterrichtsqualität: Perspektiven von Expertinnen und Experten 12) }}},
  volume       = {{12}},
  year         = {{2021}},
}

@inproceedings{26830,
  author       = {{Mager, Thomas and Jürgenhake, Christoph and Dumitrescu, Roman}},
  booktitle    = {{14th International Congress Molded Interconnect Devices (MID)}},
  location     = {{Amberg}},
  pages        = {{1--9}},
  title        = {{{Approach for a modular design methodology for an efficient development of 3D MID components}}},
  year         = {{2021}},
}

@inbook{26874,
  author       = {{Klünder, Nina}},
  booktitle    = {{Wörterbuch. Soziale Arbeit}},
  editor       = {{Amthor, Ralph-Christian and Goldberg, Brigitta and Hansbauer, Peter and Landes, Benjamin and Wintergerst, Theresia}},
  isbn         = {{978-3-7799-3869-9}},
  pages        = {{997--999}},
  publisher    = {{Beltz Juventa}},
  title        = {{{Wörterbuch. Soziale Arbeit}}},
  year         = {{2021}},
}

@article{27007,
  abstract     = {{<jats:title>Abstract</jats:title><jats:sec>
                <jats:title>Purpose</jats:title>
                <jats:p>To examine the association between fructose intake in adolescence and fatty liver indices (hepatic steatosis index (HSI), fatty liver index (FLI)) in young adulthood.</jats:p>
              </jats:sec><jats:sec>
                <jats:title>Methods</jats:title>
                <jats:p>Overall, 246 participants of the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study who had a fasting blood sample in adulthood (18–36 years), at least two 3-day weighed dietary records for calculating fructose intakes and other fructose-containing sugars (total (TS), free (FS), added sugar (AS)) as well as two complete 24-h urine samples for calculating sugar excretion (fructose excretion (FE), fructose + sucrose excretion (FE + SE)) in adolescence (males: 9.5–16.5 years; females: 8.5–15.5 years) were analysed using multivariable linear regression analyses.</jats:p>
              </jats:sec><jats:sec>
                <jats:title>Results</jats:title>
                <jats:p>On the level of dietary intake, no prospective associations were observed between adolescent fructose intake and both adult fatty liver indices, whereas higher FS intakes were associated with lower levels of HSI (<jats:italic>P</jats:italic><jats:sub>trend</jats:sub> = 0.02) and FLI (<jats:italic>P</jats:italic><jats:sub>trend</jats:sub> = 0.03). On the urinary excretion level, however, a higher FE (P<jats:sub>trend</jats:sub> = 0.03) and FE + SE (<jats:italic>P</jats:italic><jats:sub>trend</jats:sub> = 0.01) in adolescence were prospectively related to higher adult FLI values. No associations were observed between adolescent sugar excretion and adult HSI.</jats:p>
              </jats:sec><jats:sec>
                <jats:title>Conclusion</jats:title>
                <jats:p>The present study does not provide unambiguous support for a detrimental impact of adolescent fructose intake on adult liver health. Nonetheless, further examinations estimating exposure by means of urinary excretion as well as dietary intake levels appear warranted.</jats:p>
              </jats:sec>}},
  author       = {{Perrar, Ines and Buyken, Anette and Penczynski, Katharina J. and Remer, Thomas and Kuhnle, Gunter G. and Herder, Christian and Roden, Michael and Della Corte, Karen and Nöthlings, Ute and Alexy, Ute}},
  issn         = {{1436-6207}},
  journal      = {{European Journal of Nutrition}},
  pages        = {{3029--3041}},
  title        = {{{Relevance of fructose intake in adolescence for fatty liver indices in young adulthood}}},
  doi          = {{10.1007/s00394-020-02463-2}},
  year         = {{2021}},
}

@article{27014,
  abstract     = {{<jats:p><jats:bold>Purpose:</jats:bold> To examine the prospective relevance of dietary sugar intake (based on dietary data as well as urinary excretion data) in adolescent years for insulin sensitivity and biomarkers of inflammation in young adulthood.</jats:p><jats:p><jats:bold>Methods:</jats:bold> Overall 254 participants of the DONALD study who had at least two 3-day weighed dietary records for calculating intakes of fructose, glucose, sucrose, total, free, added sugars, total sugars from sugar-sweetened beverages (SSB), juice, and sweets/sugar or at least two complete 24 h urine samples (<jats:italic>n</jats:italic> = 221) for calculating sugar excretion (urinary fructose and urinary fructose + sucrose) in adolescence (females: 9–15 years, males: 10–16 years) and a fasting blood sample in adulthood (18–36 years), were included in multivariable linear regression analyses assessing their prospective associations with adult homeostasis model assessment insulin sensitivity (HOMA2-%S) and a pro-inflammatory score (based on CRP, IL-6, IL-18, leptin, chemerin, adiponectin).</jats:p><jats:p><jats:bold>Results:</jats:bold> On the dietary intake level, no prospective associations were observed between adolescent fructose, sucrose, glucose, added, free, total sugar, or total sugar from SSB, juice or sweets/sugar intake and adult HOMA2-%S (<jats:italic>p</jats:italic> &amp;gt; 0.01). On the urinary level, however, higher excreted fructose levels were associated with improved adult HOMA2-%S (<jats:italic>p</jats:italic> = 0.008) among females only. No associations were observed between dietary or urinary sugars and the adult pro-inflammatory score (<jats:italic>p</jats:italic> &amp;gt; 0.01).</jats:p><jats:p><jats:bold>Conclusion:</jats:bold> The present study did not provide support that dietary sugar consumed in adolescence is associated with adult insulin sensitivity. The one potential exception was the moderate dietary consumption of fructose, which showed a beneficial association with adult fasting insulin and insulin sensitivity.</jats:p>}},
  author       = {{Della Corte, Karen A. and Penczynski, Katharina and Kuhnle, Gunter and Perrar, Ines and Herder, Christian and Roden, Michael and Wudy, Stefan A. and Remer, Thomas and Alexy, Ute and Buyken, Anette}},
  issn         = {{2296-861X}},
  journal      = {{Frontiers in Nutrition}},
  title        = {{{The Prospective Association of Dietary Sugar Intake in Adolescence With Risk Markers of Type 2 Diabetes in Young Adulthood}}},
  doi          = {{10.3389/fnut.2020.615684}},
  year         = {{2021}},
}

@article{27114,
  abstract     = {{<jats:title>Abstract</jats:title><jats:sec>
              <jats:title>Background/objectives</jats:title>
              <jats:p>Adolescence is a critical period for both the development of overweight and the transition toward a later chronotype, often accompanied by an increase in social jetlag. This study assessed whether changes in chronotype and social jetlag, are linked to changes in body composition during adolescence.</jats:p>
            </jats:sec><jats:sec>
              <jats:title>Subjects/methods</jats:title>
              <jats:p>We used data from the DONALD open cohort study, collected between 2014 and 2019, from 213 adolescents (9–17 years at baseline, 45% females) having at least two measures of chronotype and anthropometry (<jats:italic>N</jats:italic> = 572). Chronotype was assessed with the Munich Chronotype Questionnaire and defined as: midpoint of sleep corrected for sleep-debt (MSFsc) accumulated over the week (later MSFsc represents later chronotype). Social jetlag (SJL) defines the difference between midpoint of sleep during week and weekend. Calculations for Fat Free Mass Index (FFMI [kg/m<jats:sup>2</jats:sup>)]) and Fat Mass Index (FMI) [kg/m<jats:sup>2</jats:sup>)]) were based on body fat percentage, weight, and height. To analyze the associations, we used linear mixed-effect regression models. Finally, the total cohort was split into three biologically relevant age groups (cut-off set at &lt;12 years, ≥12 to ≤15 years and &gt;15 years).</jats:p>
            </jats:sec><jats:sec>
              <jats:title>Results</jats:title>
              <jats:p>Median follow-up was 2.1 years. Overall, change toward a later chronotype was significantly related with an increase in FMI (ß: 0.05, 95% CI: 0.01–0.08). A 1 h increase in social jetlag predicted an increase in BMI-SDS of 0.08 SDS units (95% CI: 0.01–0.14) and in FMI of 0.04 kg/m2 (95% CI: 0.003–0.08). Associations were stronger for the age group ≥12 to ≤15 years (<jats:italic>p</jats:italic> for interaction: &lt;0.001). No relationship was found with FFMI.</jats:p>
            </jats:sec><jats:sec>
              <jats:title>Conclusions</jats:title>
              <jats:p>Changes in MSFsc and SJL during adolescence were associated with concurrent changes in BMI-SDS and FMI. The age ≥12 to ≤15 years appears to be a sensitive period in which chronobiological changes were clearly associated with increasing body fatness.</jats:p>
            </jats:sec>}},
  author       = {{Jankovic, Nicole and Schmitting, Sarah and Krüger, Bettina and Nöthlings, Ute and Buyken, Anette E. and Alexy, Ute}},
  issn         = {{0954-3007}},
  journal      = {{European Journal of Clinical Nutrition}},
  title        = {{{Changes in chronotype and social jetlag during adolescence and their association with concurrent changes in BMI-SDS and body composition, in the DONALD Study}}},
  doi          = {{10.1038/s41430-021-01024-y}},
  year         = {{2021}},
}

@article{27572,
  abstract     = {{<jats:p> Zusammenfassung. Genetische Varianten beeinflussen die Gewichtsregulation und die Entwicklung von Essstörungen. Zunächst haben familienbasierte, sogenannte formalgenetische Studien den erblichen Anteil an der Gewichtsregulation und an der Ätiologie von Essstörungen beleuchtet. In einer Vielzahl von Studien zeigten sich sowohl für die Varianz des Körpergewichts als auch für die Entstehung von Essstörungen Erblichkeitsschätzer (Heritabilitätsraten) von über 50 %. Mit diesem Wissen begab man sich in den 90er-Jahren des letzten Jahrhunderts auf die Suche nach den zugrundeliegenden Genen (genauer: genetischen Varianten), die das Körpergewicht, das Essverhalten oder beide Phänotypen auf Grundlage geteilter Mechanismen beeinflussen. Zunächst wurden Kandidatengenstudien durchgeführt. Dabei untersuchte man auf Grundlage unterschiedlicher, v. a. aber pathophysiologisch plausibler Überlegungen Gene mit hoher Relevanz für die untersuchten Phänotypen. Dieser Ansatz war für Essstörungen nicht sehr erfolgreich, für die Gewichtsregulation konnte eine Handvoll Gene identifiziert werden. Verbunden mit großen methodischen Fortschritten in der genetischen Forschung und v. a. der Etablierung sogenannter genomweiter Assoziationsstudien (GWAS) Anfang der 2000er-Jahre konnten bislang über 1000 Varianten/Genorte detektiert werden, die das Körpergewicht beeinflussen. Für die Essstörung Anorexia nervosa (AN) sind aktuell acht solcher Genorte beschrieben. Diese Ergebnisse, aber auch aktuelle Ansätze zu phänotypübergreifenden Analysen lassen Einblicke in die komplexe Regulation des Körpergewichtes zu und haben zudem unerwartete Pathomechanismen für AN aufgezeigt. </jats:p>}},
  author       = {{Hirtz, Raphael and Zheng, Yiran and Rajcsanyi, Luisa S. and Libuda, Lars and Antel, Jochen and Peters, Triinu and Hebebrand, Johannes and Hinney, Anke}},
  issn         = {{1422-4917}},
  journal      = {{Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie}},
  title        = {{{Ebenen der genetischen Analyse komplexer Phänotypen am Beispiel                     der Anorexia nervosa und der Varianz des Körpergewichts}}},
  doi          = {{10.1024/1422-4917/a000829}},
  year         = {{2021}},
}

@article{27573,
  abstract     = {{<jats:p> Zusammenfassung. Einleitung: Klassische ernährungsepidemiologische Studien (Beobachtungsstudien und randomisierte Interventionsstudien) zeigen, dass die Ernährung ein wichtiger Ansatzpunkt für die Prävention und Therapie psychischer Störungen sein könnte. Diese Studientypen haben allerdings Limitationen, die bei der Ergebnisinterpretation berücksichtigt werden müssen. In dieser narrativen übersichtsarbeit wird beschrieben, wie genetische Studien ein Bindeglied darstellen können, um einen Zusammenhang zwischen Ernährung und psychischen Störungen herzustellen. Methodik: Im Artikel werden verschiedene Ansätze genetischer phänotypübergreifender Analysen sowie Beispiele für deren Anwendungen in der ernährungspsychiatrischen Forschung beschrieben. Darüber hinaus werden spezifische Voraussetzungen sowie Stärken und Schwächen diskutiert. Ergebnisse: Als Methoden genetischer phänotypübergreifender Analysen sind im Rahmen ernährungspsychiatrischer Forschung bislang genetische Korrelationsanalysen, Look-up-Analysen sowie Mendelsche Randomisierungsstudien (MR-Studien) eingesetzt worden. Genetische Korrelationsanalysen und Look-up-Analysen geben erste Hinweise auf mögliche genetische überlappungen zwischen einer psychischen Störung und einem Stoffwechselweg und/oder der Versorgung mit einem spezifischen Nährstoff. MR-Studien sind weitergehende Detailanalysen mit dem Ziel, Kausalzusammenhänge zu identifizieren, beinhalten allerdings sehr spezifische Grundvoraussetzungen für ihre Durchführung. Schlussfolgerung: Genetische phänotypübergreifende Analysen sind eine sinnvolle Ergänzung der klassischen Ernährungsepidemiologie. Insbesondere signifikante Ergebnisse von MR-Studien sind eine wichtige Grundlage zur Entwicklung geeigneter Ernährungsinterventionen, die in nachfolgenden randomisiert kontrollierten Interventionsstudien mit deutlich erhöhter Erfolgsaussicht getestet werden können. Sie sind somit wichtige Instrumente einer effizienten ernährungspsychiatrischen Forschung. </jats:p>}},
  author       = {{Libuda, Lars and Hebebrand, Johannes and Föcker, Manuel and Peters, Triinu and Hinney, Anke}},
  issn         = {{1422-4917}},
  journal      = {{Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie}},
  pages        = {{1--10}},
  title        = {{{Ernährungseffekten auf der Spur – Wie die Genetik helfen kann,                     Zusammenhänge zwischen Ernährung und seelischer Gesundheit                     aufzudecken}}},
  doi          = {{10.1024/1422-4917/a000807}},
  year         = {{2021}},
}

@article{27574,
  abstract     = {{<jats:p>In adults with major depressive disorder (MDD), a dysfunction between the hypothalamus-pituitary-adrenal (HPA) and the hypothalamus-pituitary-thyroid (HPT) axis has been shown, but the interaction of both axes has not yet been studied in adolescent major depressive disorder (MDD). Data from 273 adolescents diagnosed with MDD from two single center cross-sectional studies were used for analysis. Serum levels of thyrotropin (TSH), free levothyroxine (fT4), and cortisol were determined as indicators of basal HPT and HPA axis functioning and compared to that of adolescent controls by t-tests. Quantile regression was employed in the sample of adolescents with MDD to investigate the relationship between both axes in the normal as well as the pathological range of cortisol levels, considering confounders of both axes. In adolescent MDD, cortisol levels and TSH levels were significantly elevated in comparison to controls (<jats:italic>p</jats:italic> = &amp;lt;.001, <jats:italic>d</jats:italic> = 1.35, large effect size, and <jats:italic>p</jats:italic> = &amp;lt;.001, <jats:italic>d</jats:italic> = 0.79, moderate effect size, respectively). There was a positive linear relationship between TSH and cortisol (<jats:italic>p</jats:italic> = .003, <jats:italic>d</jats:italic> = 0.25, small effect size) at the median of cortisol levels (50<jats:sup>th</jats:sup> percentile). However, no relationship between TSH and cortisol was found in hypercortisolemia (cortisol levels at the 97.5<jats:sup>th</jats:sup> percentile). These findings imply that HPT and HPA axis dysfunction is common in adolescents with MDD and that function of both axes is only loosely related. Moreover, the regulation of the HPA and HPT axis are likely subjected to age-related maturational adjustments since findings of this study differ from those reported in adults.</jats:p>}},
  author       = {{Hirtz, Raphael and Libuda, Lars and Hinney, Anke and Föcker, Manuel and Bühlmeier, Judith and Antel, Jochen and Holterhus, Paul-Martin and Kulle, Alexandra and Kiewert, Cordula and Hebebrand, Johannes and Grasemann, Corinna}},
  issn         = {{1664-2392}},
  journal      = {{Frontiers in Endocrinology}},
  title        = {{{Lack of Evidence for a Relationship Between the Hypothalamus-Pituitary-Adrenal and the Hypothalamus-Pituitary-Thyroid Axis in Adolescent Depression}}},
  doi          = {{10.3389/fendo.2021.662243}},
  year         = {{2021}},
}

@article{27746,
  author       = {{Zhang, Xiao and Gong, Yunhui and Della Corte, Karen and Yu, Dianke and Xue, Hongmei and Shan, Shufang and Tian, Guo and Liang, Yi and Zhang, Jieyi and He, Fang and Yang, Dagang and Zhou, Rong and Bao, Wei and Buyken, Anette and Cheng, Guo}},
  issn         = {{0261-5614}},
  journal      = {{Clinical Nutrition}},
  pages        = {{2791--2799}},
  title        = {{{Relevance of dietary glycemic index, glycemic load and fiber intake before and during pregnancy for the risk of gestational diabetes mellitus and maternal glucose homeostasis}}},
  doi          = {{10.1016/j.clnu.2021.03.041}},
  year         = {{2021}},
}

@article{27790,
  author       = {{Nyasordzi, Juliana and Conrad, Johanna and Goletzke, Janina and Ludwig-Walz, Helena and Herder, Christian and Roden, Michael and Wudy, Stefan A. and Hua, Yifan and Remer, Thomas and Buyken, Anette}},
  issn         = {{0939-4753}},
  journal      = {{Nutrition, Metabolism and Cardiovascular Diseases}},
  pages        = {{2109--2121}},
  title        = {{{Early life factors and their relevance for markers of cardiometabolic risk in early adulthood}}},
  doi          = {{10.1016/j.numecd.2021.03.024}},
  year         = {{2021}},
}

@article{27793,
  abstract     = {{<jats:title>ABSTRACT</jats:title>
               <jats:sec>
                  <jats:title>Background</jats:title>
                  <jats:p>Reliable tables of glycemic indexes (GIs) and glycemic loads (GLs) are critical to research examining the relationship between glycemic qualities of carbohydrate in foods, diets, and health. In the 12 years since the last edition of the tables, a large amount of new data has become available.</jats:p>
               </jats:sec>
               <jats:sec>
                  <jats:title>Objectives</jats:title>
                  <jats:p>To systematically review and tabulate published and unpublished sources of reliable GI values, including an assessment of the reliability of the data.</jats:p>
               </jats:sec>
               <jats:sec>
                  <jats:title>Methods</jats:title>
                  <jats:p>This edition of the tables lists over 4000 items, a 61% increase in the number of entries compared to the 2008 edition. The data have been separated into 2 lists. The first represents more precise values derived using the methodology recommended by the International Standards Organization (∼2100 items). The second list contains values determined using less robust methods, including using limited numbers of healthy subjects or with a large SEM (∼1900 food items).</jats:p>
               </jats:sec>
               <jats:sec>
                  <jats:title>Results</jats:title>
                  <jats:p>Dairy products, legumes, pasta, and fruits were usually low-GI foods (≤55 on the 100-point glucose scale) and had consistent values around the world. Cereals and cereal products, however, including whole-grain or whole-meal versions, showed wide variation in GI values, presumably arising from variations in manufacturing methods. Breads, breakfast cereals, rice, savory snack products, and regional foods were available in high-, medium-, and low-GI versions. Most varieties of potato were high-GI foods, but specific low-GI varieties have now been identified.</jats:p>
               </jats:sec>
               <jats:sec>
                  <jats:title>Conclusions</jats:title>
                  <jats:p>The availability of new data on the GIs of foods will facilitate wider research and application of the twin concepts of GI and GL. Although the 2021 edition of the tables improves the quality and quantity of GI data available for research and clinical practice, GI testing of regional foods remains a priority. This systematic review was registered in PROSPERO as #171204.</jats:p>
               </jats:sec>}},
  author       = {{Atkinson, Fiona S and Brand-Miller, Jennie C and Foster-Powell, Kaye and Buyken, Anette and Goletzke, Janina}},
  issn         = {{0002-9165}},
  journal      = {{The American Journal of Clinical Nutrition}},
  pages        = {{1625--1632}},
  title        = {{{International tables of glycemic index and glycemic load values 2021: a systematic review}}},
  doi          = {{10.1093/ajcn/nqab233}},
  year         = {{2021}},
}

@article{21004,
  abstract     = {{Automated machine learning (AutoML) supports the algorithmic construction and data-specific customization of machine learning pipelines, including the selection, combination, and parametrization of machine learning algorithms as main constituents. Generally speaking, AutoML approaches comprise two major components: a search space model and an optimizer for traversing the space. Recent approaches have shown impressive results in the realm of supervised learning, most notably (single-label) classification (SLC). Moreover, first attempts at extending these approaches towards multi-label classification (MLC) have been made. While the space of candidate pipelines is already huge in SLC, the complexity of the search space is raised to an even higher power in MLC. One may wonder, therefore, whether and to what extent optimizers established for SLC can scale to this increased complexity, and how they compare to each other. This paper makes the following contributions: First, we survey existing approaches to AutoML for MLC. Second, we augment these approaches with optimizers not previously tried for MLC. Third, we propose a benchmarking framework that supports a fair and systematic comparison. Fourth, we conduct an extensive experimental study, evaluating the methods on a suite of MLC problems. We find a grammar-based best-first search to compare favorably to other optimizers.}},
  author       = {{Wever, Marcel Dominik and Tornede, Alexander and Mohr, Felix and Hüllermeier, Eyke}},
  issn         = {{0162-8828}},
  journal      = {{IEEE Transactions on Pattern Analysis and Machine Intelligence}},
  keywords     = {{Automated Machine Learning, Multi Label Classification, Hierarchical Planning, Bayesian Optimization}},
  pages        = {{1--1}},
  title        = {{{AutoML for Multi-Label Classification: Overview and Empirical Evaluation}}},
  doi          = {{10.1109/tpami.2021.3051276}},
  year         = {{2021}},
}

@article{21264,
  abstract     = {{<jats:title>Abstract</jats:title><jats:sec>
                <jats:title>Background</jats:title>
                <jats:p>Hand amputation can have a truly debilitating impact on the life of the affected person. A multifunctional myoelectric prosthesis controlled using pattern classification can be used to restore some of the lost motor abilities. However, learning to control an advanced prosthesis can be a challenging task, but virtual and augmented reality (AR) provide means to create an engaging and motivating training.</jats:p>
              </jats:sec><jats:sec>
                <jats:title>Methods</jats:title>
                <jats:p>In this study, we present a novel training framework that integrates virtual elements within a real scene (AR) while allowing the view from the first-person perspective. The framework was evaluated in 13 able-bodied subjects and a limb-deficient person divided into intervention (IG) and control (CG) groups. The IG received training by performing simulated clothespin task and both groups conducted a pre- and posttest with a real prosthesis. When training with the AR, the subjects received visual feedback on the generated grasping force. The main outcome measure was the number of pins that were successfully transferred within 20 min (task duration), while the number of dropped and broken pins were also registered. The participants were asked to score the difficulty of the real task (posttest), fun-factor and motivation, as well as the utility of the feedback.</jats:p>
              </jats:sec><jats:sec>
                <jats:title>Results</jats:title>
                <jats:p>The performance (median/interquartile range) consistently increased during the training sessions (4/3 to 22/4). While the results were similar for the two groups in the pretest, the performance improved in the posttest only in IG. In addition, the subjects in IG transferred significantly more pins (28/10.5 versus 14.5/11), and dropped (1/2.5 versus 3.5/2) and broke (5/3.8 versus 14.5/9) significantly fewer pins in the posttest compared to CG. The participants in IG assigned (mean ± std) significantly lower scores to the difficulty compared to CG (5.2 ± 1.9 versus 7.1 ± 0.9), and they highly rated the fun factor (8.7 ± 1.3) and usefulness of feedback (8.5 ± 1.7).</jats:p>
              </jats:sec><jats:sec>
                <jats:title>Conclusion</jats:title>
                <jats:p>The results demonstrated that the proposed AR system allows for the transfer of skills from the simulated to the real task while providing a positive user experience. The present study demonstrates the effectiveness and flexibility of the proposed AR framework. Importantly, the developed system is open source and available for download and further development.</jats:p>
              </jats:sec>}},
  author       = {{Boschmann, Alexander and Neuhaus, Dorothee and Vogt, Sarah and Kaltschmidt, Christian and Platzner, Marco and Dosen, Strahinja}},
  issn         = {{1743-0003}},
  journal      = {{Journal of NeuroEngineering and Rehabilitation}},
  title        = {{{Immersive augmented reality system for the training of pattern classification control with a myoelectric prosthesis}}},
  doi          = {{10.1186/s12984-021-00822-6}},
  year         = {{2021}},
}

@article{21337,
  abstract     = {{We present a flexible trust region descend algorithm for unconstrained and
convexly constrained multiobjective optimization problems. It is targeted at
heterogeneous and expensive problems, i.e., problems that have at least one
objective function that is computationally expensive. The method is
derivative-free in the sense that neither need derivative information be
available for the expensive objectives nor are gradients approximated using
repeated function evaluations as is the case in finite-difference methods.
Instead, a multiobjective trust region approach is used that works similarly to
its well-known scalar pendants. Local surrogate models constructed from
evaluation data of the true objective functions are employed to compute
possible descent directions. In contrast to existing multiobjective trust
region algorithms, these surrogates are not polynomial but carefully
constructed radial basis function networks. This has the important advantage
that the number of data points scales linearly with the parameter space
dimension. The local models qualify as fully linear and the corresponding
general scalar framework is adapted for problems with multiple objectives.
Convergence to Pareto critical points is proven and numerical examples
illustrate our findings.}},
  author       = {{Berkemeier, Manuel Bastian and Peitz, Sebastian}},
  issn         = {{2297-8747}},
  journal      = {{Mathematical and Computational Applications}},
  number       = {{2}},
  title        = {{{Derivative-Free Multiobjective Trust Region Descent Method Using Radial  Basis Function Surrogate Models}}},
  doi          = {{10.3390/mca26020031}},
  volume       = {{26}},
  year         = {{2021}},
}

@article{21633,
  abstract     = {{<jats:p>Higher quality requirements by customers demand higher precision and accuracy from manufacturing processes. Application oriented preparation of semi-finished materials is key for subsequent forming operations, therefore, straightening machines are employed. Straightening strengthens the material by increasing plastic deformation by means of strain hardening, resulting in undesirable reduction in formability when processing high strength materials, in particular. Conventional roll-type straightening machines process either bars or strips. This is achieved upon passing material between rolls arranged in two staggered rows. However, conventional straightening processes do not adapt to the local varying distortion of coiled strips. Innovative, self-correcting process control techniques, which adapt to the initial geometric characteristics of the strip, present a promising approach to fix this issue through optimization of the leveling process. Here, an innovative strategy to improve straightening of high strength steel materials (1.4310) is presented. This implements optimized leveling, adding minimal plastic deformation and, thus, strain hardening. To operate an intelligent straightening machine, a reliable online measurement of the surface defects is fundamentally essential. The MagnaTest, which is developed for material testing, is made feasible for such purposes after calibrating for curvature measurement. Preliminary results are promising in regards to measuring the curvature online, so that the following straightening process can be close loop controlled. The bending measurement is linked to open/closed loop control, therefore providing an optimal straightening result in regards to formability, leveling, and reduced strain hardening.</jats:p>}},
  author       = {{Bader, Fabian and Bathelt, Lukas and Djakow, Eugen and Homberg, Werner and Henke, Christian and Trächtler, Ansgar}},
  journal      = {{ESAFORM 2021}},
  title        = {{{Innovative Measurement Of Stress Superposed Steel Strip For Straightening Machines}}},
  doi          = {{10.25518/esaform21.2382}},
  year         = {{2021}},
}

@inproceedings{23576,
  author       = {{Biemelt, Patrick and Böhm, Sabrina and Gausemeier, Sandra and Trächtler, Ansgar}},
  booktitle    = {{Proceedings of the IEEE International Conference on Systems, Man, and Cybernetics (SMC)}},
  location     = {{Melbourne, Australia}},
  pages        = {{1619 -- 1626}},
  title        = {{{Subjective Evaluation of Filter- and Optimization-Based Motion Cueing Algorithms for a Hybrid Kinematics Driving Simulator}}},
  year         = {{2021}},
}

