@inproceedings{22532, abstract = {{In this publication, further elements of the newly developed inductive localization in the near field are presented. The advantage of inductive localization is the usage of the magnetic fields, which have a very low influence of non-metallic materials in the environment and thus follows good applications in the area of medicine and biochemistry. This allows a precise localization of sensor platforms in inhomogeneous mixtures of materials, where classical methods have major problems with inhomogeneous dielectric conductivity or density. The calculation of the localization of the searched object differs from other methods such as ultrasound or electromagnetic waves due to the source-free propagation of the magnetic field. Therefore, new mathematical evaluation methods and systematic adaptations are necessary, which are presented in this paper in circuit analysis. For this purpose, the exact circuit influences of one coil and the influence of another coil are investigated and which resonance circuit should be selected for both coils for a inductive localization with optimized signal strength.}}, author = {{Lange, Sven and Hedayat, Christian and Kuhn, Harald and Hilleringmann, Ulrich}}, booktitle = {{2021 Smart Systems Integration (SSI)}}, isbn = {{9781665440929}}, keywords = {{Electrotechnical Characteristics of Real Coils, Inductive Localization, Resonant Circuit, Mutual Inductance, Near-Field}}, location = {{Grenoble, France }}, publisher = {{IEEE}}, title = {{{Adaptation and Optimization of Planar Coils for a More Accurate and Far-Reaching Magnetic Field-Based Localization in the Near Field}}}, doi = {{10.1109/ssi52265.2021.9466958}}, year = {{2021}}, } @article{22637, abstract = {{Abstract Doxorubicin (DOX) is a common drug in cancer chemotherapy, and its high DNA-binding affinity can be harnessed in preparing DOX-loaded DNA nanostructures for targeted delivery and therapeutics. Although DOX has been widely studied, the existing literature of DOX-loaded DNA-carriers remains limited and incoherent. Here, based on an in-depth spectroscopic analysis, we characterize and optimize the DOX loading into different 2D and 3D scaffolded DNA origami nanostructures (DONs). In our experimental conditions, all DONs show similar DOX binding capacities (one DOX molecule per two to three base pairs), and the binding equilibrium is reached within seconds, remarkably faster than previously acknowledged. To characterize drug release profiles, DON degradation and DOX release from the complexes upon DNase I digestion was studied. For the employed DONs, the relative doses (DOX molecules released per unit time) may vary by two orders of magnitude depending on the DON superstructure. In addition, we identify DOX aggregation mechanisms and spectral changes linked to pH, magnesium, and DOX concentration. These features have been largely ignored in experimenting with DNA nanostructures, but are probably the major sources of the incoherence of the experimental results so far. Therefore, we believe this work can act as a guide to tailoring the release profiles and developing better drug delivery systems based on DNA-carriers.}}, author = {{Ijäs, Heini and Shen, Boxuan and Heuer-Jungemann, Amelie and Keller, Adrian and Kostiainen, Mauri A and Liedl, Tim and Ihalainen, Janne A and Linko, Veikko}}, issn = {{0305-1048}}, journal = {{Nucleic Acids Research}}, pages = {{3048--3062}}, title = {{{Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release}}}, doi = {{10.1093/nar/gkab097}}, volume = {{49}}, year = {{2021}}, } @article{23023, abstract = {{DNA origami nanostructures (DONs) are promising substrates for the single-molecule investigation of biomolecular reactions and dynamics by in situ atomic force microscopy (AFM). For this, they are typically immobilized on mica substrates by adding millimolar concentrations of Mg2+ ions to the sample solution, which enable the adsorption of the negatively charged DONs at the like-charged mica surface. These non-physiological Mg2+ concentrations, however, present a serious limitation in such experiments as they may interfere with the reactions and processes under investigation. Therefore, we here evaluate three approaches to efficiently immobilize DONs at mica surfaces under essentially Mg2+-free conditions. These approaches rely on the pre-adsorption of different multivalent cations, i.e., Ni2+, poly-l-lysine (PLL), and spermidine (Spdn). DON adsorption is studied in phosphate-buffered saline (PBS) and pure water. In general, Ni2+ shows the worst performance with heavily deformed DONs. For 2D DON triangles, adsorption at PLL- and in particular Spdn-modified mica may outperform even Mg2+-mediated adsorption in terms of surface coverage, depending on the employed solution. For 3D six-helix bundles, less pronounced differences between the individual strategies are observed. Our results provide some general guidance for the immobilization of DONs at mica surfaces under Mg2+-free conditions and may aid future in situ AFM studies.}}, author = {{Xin, Yang and Zargariantabrizi, Amir Ardalan and Grundmeier, Guido and Keller, Adrian}}, issn = {{1420-3049}}, journal = {{Molecules}}, pages = {{4798}}, title = {{{Magnesium-Free Immobilization of DNA Origami Nanostructures at Mica Surfaces for Atomic Force Microscopy}}}, doi = {{10.3390/molecules26164798}}, volume = {{26}}, year = {{2021}}, } @article{16867, abstract = {{In this article, we present an efficient descent method for locally Lipschitz continuous multiobjective optimization problems (MOPs). The method is realized by combining a theoretical result regarding the computation of descent directions for nonsmooth MOPs with a practical method to approximate the subdifferentials of the objective functions. We show convergence to points which satisfy a necessary condition for Pareto optimality. Using a set of test problems, we compare our method to the multiobjective proximal bundle method by M\"akel\"a. The results indicate that our method is competitive while being easier to implement. While the number of objective function evaluations is larger, the overall number of subgradient evaluations is lower. Finally, we show that our method can be combined with a subdivision algorithm to compute entire Pareto sets of nonsmooth MOPs.}}, author = {{Gebken, Bennet and Peitz, Sebastian}}, journal = {{Journal of Optimization Theory and Applications}}, pages = {{696--723}}, title = {{{An efficient descent method for locally Lipschitz multiobjective optimization problems}}}, doi = {{10.1007/s10957-020-01803-w}}, volume = {{188}}, year = {{2021}}, } @article{16295, abstract = {{It is a challenging task to identify the objectives on which a certain decision was based, in particular if several, potentially conflicting criteria are equally important and a continuous set of optimal compromise decisions exists. This task can be understood as the inverse problem of multiobjective optimization, where the goal is to find the objective function vector of a given Pareto set. To this end, we present a method to construct the objective function vector of an unconstrained multiobjective optimization problem (MOP) such that the Pareto critical set contains a given set of data points with prescribed KKT multipliers. If such an MOP can not be found, then the method instead produces an MOP whose Pareto critical set is at least close to the data points. The key idea is to consider the objective function vector in the multiobjective KKT conditions as variable and then search for the objectives that minimize the Euclidean norm of the resulting system of equations. By expressing the objectives in a finite-dimensional basis, we transform this problem into a homogeneous, linear system of equations that can be solved efficiently. Potential applications of this approach include the identification of objectives (both from clean and noisy data) and the construction of surrogate models for expensive MOPs.}}, author = {{Gebken, Bennet and Peitz, Sebastian}}, journal = {{Journal of Global Optimization}}, pages = {{3--29}}, publisher = {{Springer}}, title = {{{Inverse multiobjective optimization: Inferring decision criteria from data}}}, doi = {{10.1007/s10898-020-00983-z}}, volume = {{80}}, year = {{2021}}, } @inproceedings{21953, author = {{Witschen, Linus Matthias and Wiersema, Tobias and Raeisi Nafchi, Masood and Bockhorn, Arne and Platzner, Marco}}, booktitle = {{Proceedings of International Symposium on Applied Reconfigurable Computing (ARC'21)}}, editor = {{Hannig, Frank and Derrien, Steven and Diniz, Pedro and Chillet, Daniel}}, location = {{Virtual conference}}, publisher = {{Springer Lecture Notes in Computer Science}}, title = {{{Timing Optimization for Virtual FPGA Configurations}}}, doi = {{10.1007/978-3-030-79025-7_4}}, year = {{2021}}, } @article{29653, author = {{Weber, Daniel and Heid, Stefan and Bode, Henrik and Lange, Jarren and Hüllermeier, Eyke and Wallscheid, Oliver}}, journal = {{IEEE Access}}, pages = {{35654–35669}}, publisher = {{IEEE}}, title = {{{Safe Bayesian Optimization for Data-Driven Power Electronics Control Design in Microgrids: From Simulations to Real-World Experiments}}}, doi = {{10.1109/ACCESS.2021.3062144}}, volume = {{9}}, year = {{2021}}, } @article{30906, abstract = {{Abstract Background Hand amputation can have a truly debilitating impact on the life of the affected person. A multifunctional myoelectric prosthesis controlled using pattern classification can be used to restore some of the lost motor abilities. However, learning to control an advanced prosthesis can be a challenging task, but virtual and augmented reality (AR) provide means to create an engaging and motivating training. Methods In this study, we present a novel training framework that integrates virtual elements within a real scene (AR) while allowing the view from the first-person perspective. The framework was evaluated in 13 able-bodied subjects and a limb-deficient person divided into intervention (IG) and control (CG) groups. The IG received training by performing simulated clothespin task and both groups conducted a pre- and posttest with a real prosthesis. When training with the AR, the subjects received visual feedback on the generated grasping force. The main outcome measure was the number of pins that were successfully transferred within 20 min (task duration), while the number of dropped and broken pins were also registered. The participants were asked to score the difficulty of the real task (posttest), fun-factor and motivation, as well as the utility of the feedback. Results The performance (median/interquartile range) consistently increased during the training sessions (4/3 to 22/4). While the results were similar for the two groups in the pretest, the performance improved in the posttest only in IG. In addition, the subjects in IG transferred significantly more pins (28/10.5 versus 14.5/11), and dropped (1/2.5 versus 3.5/2) and broke (5/3.8 versus 14.5/9) significantly fewer pins in the posttest compared to CG. The participants in IG assigned (mean ± std) significantly lower scores to the difficulty compared to CG (5.2 ± 1.9 versus 7.1 ± 0.9), and they highly rated the fun factor (8.7 ± 1.3) and usefulness of feedback (8.5 ± 1.7). Conclusion The results demonstrated that the proposed AR system allows for the transfer of skills from the simulated to the real task while providing a positive user experience. The present study demonstrates the effectiveness and flexibility of the proposed AR framework. Importantly, the developed system is open source and available for download and further development. }}, author = {{Boschmann, Alexander and Neuhaus, Dorothee and Vogt, Sarah and Kaltschmidt, Christian and Platzner, Marco and Dosen, Strahinja}}, issn = {{1743-0003}}, journal = {{Journal of NeuroEngineering and Rehabilitation}}, keywords = {{Health Informatics, Rehabilitation}}, number = {{1}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Immersive augmented reality system for the training of pattern classification control with a myoelectric prosthesis}}}, doi = {{10.1186/s12984-021-00822-6}}, volume = {{18}}, year = {{2021}}, } @inproceedings{26821, author = {{Wibbeke, Tim Michael and Bartley, Auerélie and Chudalla, Nick and Meschut, Gerson}}, booktitle = {{Fahrzeug + Karosserie und kfz-betrieb (Hrsg,); Tagungsband zu den Würzburger Karosserie- und Schadenstagen 22./23. Oktober 2021}}, title = {{{Fügen und Trennen von Kfz-Karosseriestrukturen in Leichtbauweise}}}, year = {{2021}}, } @article{23494, author = {{Stumpe, Miriam and Rößler, David and Schryen, Guido and Kliewer, Natalia}}, journal = {{EURO Journal on Transportation and Logistics}}, title = {{{Study on Sensitivity of Electric Bus Systems under Simultaneous Optimization of Charging Infrastructure and Vehicle Schedules}}}, doi = {{https://doi.org/10.1016/j.ejtl.2021.100049}}, volume = {{10}}, year = {{2021}}, } @article{30649, abstract = {{Nowadays, the production of modern lightweight structures, like a body in white structure requires a wide variety of mechanical joining processes. To fulfill the various demands, mechanical joining processes and joining elements (JE) are used. Very often, they are adapted to the application, which leads in turn to a numerous of different variants, high costs, and loss of the process chain versatility. To overcome this drawback, an innovative approach is the usage of individually produced and task-adapted JE, the so-called friction spun joint connectors (FSJC). These connectors can be modified in shape as well as in material properties. This flexibility offers high potential for lightweight design but also increases the necessary analytical effort regarding the forming process as well as the manufactured joint's properties. Therefore, a new analysis strategy based on the Finite-Element-Method (FEM) is proposed, which numerically determines the local load bearing capacity within a given joint in order to identify the critical regions for load transfer. The process of joining element manufacturing and the analysis strategy will be described in detail and optimization results of the joints are shown. Numerical results are discussed and possible recommendations for joint manufacturing are derived.}}, author = {{Wischer, Christian and Steinfelder, Christian and Homberg, Werner and Brosius, Alexander}}, journal = {{IOP Conference Series: Materials Science and Engineering}}, pages = {{012007}}, title = {{{Joining with Friction Spun Joint Connectors – Manufacturing and Analysis}}}, doi = {{10.1088/1757-899x/1157/1/012007}}, volume = {{1157}}, year = {{2021}}, } @article{16294, abstract = {{Model predictive control is a prominent approach to construct a feedback control loop for dynamical systems. Due to real-time constraints, the major challenge in MPC is to solve model-based optimal control problems in a very short amount of time. For linear-quadratic problems, Bemporad et al. have proposed an explicit formulation where the underlying optimization problems are solved a priori in an offline phase. In this article, we present an extension of this concept in two significant ways. We consider nonlinear problems and - more importantly - problems with multiple conflicting objective functions. In the offline phase, we build a library of Pareto optimal solutions from which we then obtain a valid compromise solution in the online phase according to a decision maker's preference. Since the standard multi-parametric programming approach is no longer valid in this situation, we instead use interpolation between different entries of the library. To reduce the number of problems that have to be solved in the offline phase, we exploit symmetries in the dynamical system and the corresponding multiobjective optimal control problem. The results are verified using two different examples from autonomous driving.}}, author = {{Ober-Blöbaum, Sina and Peitz, Sebastian}}, journal = {{International Journal of Robust and Nonlinear Control}}, pages = {{380--403}}, title = {{{Explicit multiobjective model predictive control for nonlinear systems with symmetries}}}, doi = {{10.1002/rnc.5281}}, volume = {{31(2)}}, year = {{2021}}, } @article{24140, author = {{Ramaswamy, Arunselvan and Redder, Adrian and Quevedo, Daniel E.}}, journal = {{IEEE Transactions on Automatic Control}}, pages = {{1--1}}, title = {{{Distributed optimization over time-varying networks with stochastic information delays}}}, doi = {{10.1109/TAC.2021.3108492}}, year = {{2021}}, } @inproceedings{21726, author = {{Triebus, Marcel and Tröster, Thomas}}, booktitle = {{9th NRW Nano Conference - Innovations in Materials and Applications}}, location = {{Web}}, title = {{{HyOpt - Optimization-Based Development of Hybrid Materials}}}, year = {{2021}}, } @article{33008, author = {{Ludwig-Walz, Helena and Nyasordzi, Juliana and Weber, Katharina S. and Buyken, Anette and Kroke, Anja}}, issn = {{0939-4753}}, journal = {{Nutrition, Metabolism and Cardiovascular Diseases}}, keywords = {{Cardiology and Cardiovascular Medicine, Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous)}}, number = {{4}}, pages = {{833--852}}, publisher = {{Elsevier BV}}, title = {{{Maternal pregnancy weight or gestational weight gain and offspring's blood pressure: A systematic review}}}, doi = {{10.1016/j.numecd.2021.11.011}}, volume = {{32}}, year = {{2021}}, } @article{27575, abstract = {{There is a distinct increase in the prevalence of depression with the onset of puberty. The role of peripubertal testosterone levels in boys in this context is insufficiently understood and may be modulated by a functional polymorphism of the androgen receptor gene (AR), a variable number of CAG repeats. Moreover, there is preliminary evidence that the relationship between testosterone, CAG repeat length, and the severity of depressive symptoms may differ between subclinical and overt depression, but this has neither been studied in a clinical sample of adolescents with depression nor compared between subclinical and overt depression in an adequately powered study. To investigate the relationship between free testosterone, CAG repeat length of the AR, depression status (subclinical vs. overt), and the severity of depressive symptoms, 118 boys treated as in- or daycare patients at a single psychiatric hospital were studied. Of these, 73 boys had at least mild depressive symptoms according to the Beck Depression Inventory-II (BDI-II > 13). Higher-order moderation analysis in the multiple regression framework revealed a constant relationship between free testosterone and depression severity irrespective of the number of CAG repeats in adolescents with a BDI-II score ≤ 13. In adolescents with a BDI-II score > 13, however, there was a significant negative relationship between free testosterone and BDI-II score in patients with <19 CAG repeats and a significant positive relationship regarding free testosterone and BDI-II score in those with more than 28 CAG repeats, even when considering important covariates. These results suggest that the effects of testosterone on mood in male adolescents with depression depend on the genetic make-up of the AR as well as on depression status. This complex relationship should be considered by future studies addressing mental health issues against an endocrine background and may, moreover, contribute to tailored treatment concepts in psychiatric medicine, especially in adults.}}, author = {{Hirtz, Raphael and Libuda, Lars and Hinney, Anke and Föcker, Manuel and Bühlmeier, Judith and Holterhus, Paul-Martin and Kulle, Alexandra and Kiewert, Cordula and Hebebrand, Johannes and Grasemann, Corinna}}, issn = {{1664-0640}}, journal = {{Frontiers in Psychiatry}}, title = {{{Size Matters: The CAG Repeat Length of the Androgen Receptor Gene, Testosterone, and Male Adolescent Depression Severity}}}, doi = {{10.3389/fpsyt.2021.732759}}, year = {{2021}}, } @article{27571, abstract = {{(1) Background: Evidence has accumulated that patients with anorexia nervosa (AN) are at higher risk for vitamin D deficiency than healthy controls. In epidemiologic studies, low 25(OH) vitamin D (25(OH)D) levels were associated with depression. This study analyzed the relationship between 25(OH)D serum levels in adolescent patients and AN and depressive symptoms over the course of treatment. (2) Methods: 25(OH)D levels and depressive symptoms were analyzed in 93 adolescent (in-)patients with AN from the Anorexia Nervosa Day patient versus Inpatient (ANDI) multicenter trial at clinic admission, discharge, and 1 year follow up. Mixed regression models were used to analyze the relationship between 25(OH)D levels and depressive symptoms assessed by the Beck Depression Inventory (BDI-II). (3) Results: Although mean 25(OH)D levels constantly remained in recommended ranges (≥50 nmol/L) during AN treatment, levels decreased from (in)patient admission to 1 year follow up. Levels of 25(OH)D were neither cross-sectionally, prospectively, nor longitudinally associated with the BDI-II score. (4) Conclusions: This study did not confirm that 25(OH)D levels are associated with depressive symptoms in patients with AN. However, increasing risks of vitamin D deficiency over the course of AN treatment indicate that clinicians should monitor 25(OH)D levels.}}, author = {{Föcker, Manuel and Timmesfeld, Nina and Bühlmeier, Judith and Zwanziger, Denise and Führer, Dagmar and Grasemann, Corinna and Ehrlich, Stefan and Egberts, Karin and Fleischhaker, Christian and Wewetzer, Christoph and Wessing, Ida and Seitz, Jochen and Herpertz-Dahlmann, Beate and Hebebrand, Johannes and Libuda, Lars}}, issn = {{2072-6643}}, journal = {{Nutrients}}, title = {{{Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms}}}, doi = {{10.3390/nu13072356}}, year = {{2021}}, } @article{26632, abstract = {{AbstractAnorexia nervosa (AN) is a severe eating disorder and often associated with altered humoral immune responses. However, distinct B cell maturation stages in peripheral blood in adolescents with AN have not been characterized. Treatment effects and the relationship between clinical and B cell parameters are also not fully understood. Here we investigated the phenotype of circulating B cell subsets and the relationship with body composition in adolescents with AN before (T0, n = 24) and after 6 weeks (T1, n = 20) of treatment. Using multi-parameter flow cytometry, we found increased percentages of antigen-experienced B cells and plasmablasts in patients with AN compared to healthy controls (n = 20). In contrast, percentages of CD1d+CD5+ B cells and transitional B cells with immunoregulatory roles were reduced at T0 and T1. These B cell frequencies correlated positively with fat mass, fat mass index (FMI), free fat mass index, and body mass index standard deviation score. In addition, scavenger-like receptor CD5 expression levels were downregulated on transitional B cells and correlated with fat mass and FMI in AN. Our findings that regulatory B cell subgroups were reduced in AN and their strong relationship with body composition parameters point toward an impact of immunoregulatory B cells in the pathogenesis of AN.}}, author = {{Freff, Jana and Schwarte, Kathrin and Bröker, Lisa and Bühlmeier, Judith and Kraft, Isabelle and Öztürk, Dana and Hinney, Anke and Arolt, Volker and Dannlowski, Udo and Romer, Georg and Baune, Bernhard T. and Hebebrand, Johannes and Föcker, Manuel and Alferink, Judith}}, issn = {{2045-2322}}, journal = {{Scientific Reports}}, title = {{{Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa}}}, doi = {{10.1038/s41598-020-80693-4}}, year = {{2021}}, } @article{26525, author = {{Hebebrand, Johannes and Antel, Jochen and Tan, Susanne and Wabitsch, Martin and Wiesing, Urban and Barth, Nikolaus and Ludwig, Christine and Bühlmeier, Judith and Libuda, Lars and Milos, Gabriella and Hinney, Anke}}, issn = {{1422-4917}}, journal = {{Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie}}, pages = {{1--5}}, title = {{{Kurzzeitige Behandlung von Patient_innen mit Anorexia nervosa mit rekombinant hergestelltem Human-Leptin (Metreleptin): Rasch einsetzende positive Effekte auf Stimmung, Kognition und Verhalten}}}, doi = {{10.1024/1422-4917/a000775}}, year = {{2021}}, } @article{30700, author = {{Zirngibl, C. and Dworschak, F. and Schleich, B. and Wartzack, S.}}, journal = {{Production Engineering}}, title = {{{Application of reinforcement learning for the optimization of clinch joint characteristics}}}, doi = {{10.1007/s11740-021-01098-4}}, year = {{2021}}, }