---
_id: '28646'
author:
- first_name: 'Sebastian '
  full_name: 'Pook, Sebastian '
  last_name: Pook
- first_name: J{\"u}rgen
  full_name: Gausemeier, J{\"u}rgen
  last_name: Gausemeier
- first_name: Rafal
  full_name: ' Dorociak, Rafal'
  last_name: ' Dorociak'
citation:
  ama: 'Pook S, Gausemeier J,  Dorociak R. Securing the reliability of tomorrow’s
    systems with Self-Optimization. In: ; 2012.'
  apa: "Pook, S., Gausemeier, J., &#38;  Dorociak, R. (2012). <i>Securing the reliability
    of tomorrow’s systems with Self-Optimization</i>. The Annual Reliability and Maintainability
    Symposium \x96 RAMS 2012."
  bibtex: '@inproceedings{Pook_Gausemeier_ Dorociak_2012, place={Reno, Nevada, USA},
    title={Securing the reliability of tomorrow’s systems with Self-Optimization},
    author={Pook, Sebastian  and Gausemeier, J{\"u}rgen and  Dorociak, Rafal}, year={2012}
    }'
  chicago: Pook, Sebastian , J{\"u}rgen Gausemeier, and Rafal  Dorociak. “Securing
    the Reliability of Tomorrow’s Systems with Self-Optimization.” Reno, Nevada, USA,
    2012.
  ieee: "S. Pook, J. Gausemeier, and R.  Dorociak, “Securing the reliability of tomorrow’s
    systems with Self-Optimization,” presented at the The Annual Reliability and Maintainability
    Symposium \x96 RAMS 2012, 2012."
  mla: Pook, Sebastian, et al. <i>Securing the Reliability of Tomorrow’s Systems with
    Self-Optimization</i>. 2012.
  short: 'S. Pook, J. Gausemeier, R.  Dorociak, in: Reno, Nevada, USA, 2012.'
conference:
  end_date: 2012-01-26
  name: "The Annual Reliability and Maintainability Symposium \x96 RAMS 2012"
  start_date: 2012-01-23
date_created: 2021-12-11T18:14:14Z
date_updated: 2022-01-25T18:07:26Z
department:
- _id: '676'
language:
- iso: eng
place: Reno, Nevada, USA
publication_status: published
status: public
title: Securing the reliability of tomorrow's systems with Self-Optimization
type: conference
user_id: '71124'
year: '2012'
...
---
_id: '25810'
abstract:
- lang: eng
  text: "The analysis of production systems by the use of discrete, event-based simulation
    is widely used and accepted as decision support method. It aims either at the
    comparison of competitive designs or the identification of a “best possible” configuration
    of the simulation model. Here, combinatorial techniques of simulation and optimization
    methods support the user in finding optimal solutions, which typically result
    in long computation times and though often prohibit a practical application in
    today’s industry. This paper presents a fast converging procedure as a combination
    of a swarm heuristic, namely the particle swarm optimization, and the material
    flow simulation to close this gap. Faster convergence is realized by a specific
    extension of classic PSO implementations. First results show the applicability
    with a simulation reference model.\r\n"
author:
- first_name: 'Christoph '
  full_name: 'Laroque, Christoph '
  last_name: Laroque
- first_name: ' Jan-Patrick'
  full_name: Pater,  Jan-Patrick
  last_name: Pater
citation:
  ama: 'Laroque C, Pater  Jan-Patrick. An Automatic Approach for Parameter Optimization
    of Material Flow Simulation Models based on Particle Swarm Optimization. In: ;
    2012:50-57.'
  apa: Laroque, C., &#38; Pater,  Jan-Patrick. (2012). <i>An Automatic Approach for
    Parameter Optimization of Material Flow Simulation Models based on Particle Swarm
    Optimization</i>. 50–57.
  bibtex: '@inproceedings{Laroque_Pater_2012, title={An Automatic Approach for Parameter
    Optimization of Material Flow Simulation Models based on Particle Swarm Optimization},
    author={Laroque, Christoph  and Pater,  Jan-Patrick}, year={2012}, pages={50–57}
    }'
  chicago: Laroque, Christoph , and  Jan-Patrick Pater. “An Automatic Approach for
    Parameter Optimization of Material Flow Simulation Models Based on Particle Swarm
    Optimization,” 50–57, 2012.
  ieee: C. Laroque and  Jan-Patrick Pater, “An Automatic Approach for Parameter Optimization
    of Material Flow Simulation Models based on Particle Swarm Optimization,” 2012,
    pp. 50–57.
  mla: Laroque, Christoph, and  Jan-Patrick Pater. <i>An Automatic Approach for Parameter
    Optimization of Material Flow Simulation Models Based on Particle Swarm Optimization</i>.
    2012, pp. 50–57.
  short: 'C. Laroque,  Jan-Patrick Pater, in: 2012, pp. 50–57.'
conference:
  name: SIMUL 2012, The Fourth International Conference on Advances in System Simulation
date_created: 2021-10-07T18:14:06Z
date_updated: 2022-01-25T18:18:19Z
department:
- _id: '671'
language:
- iso: eng
page: 50-57
publication_identifier:
  isbn:
  - 978-1-61208-234-9
publication_status: published
status: public
title: An Automatic Approach for Parameter Optimization of Material Flow Simulation
  Models based on Particle Swarm Optimization
type: conference
user_id: '71124'
year: '2012'
...
---
_id: '25811'
alternative_title:
- icEIC - DeMset - ICTA 2012
author:
- first_name: Sebastian
  full_name: Lauck, Sebastian
  last_name: Lauck
- first_name: Philip
  full_name: Hartmann, Philip
  last_name: Hartmann
- first_name: Christoph
  full_name: Laroque, Christoph
  last_name: Laroque
citation:
  ama: 'Lauck S, Hartmann P, Laroque C. Multi-Layer Architecture for Transition of
    Business-Models to common Software-Tools and Optimization of the Model-Structure
    exemplified with Microsoft SharePoint 2010. In: International Institute of Informatics
    and Systemics; 2012:20-25.'
  apa: Lauck, S., Hartmann, P., &#38; Laroque, C. (2012). <i>Multi-Layer Architecture
    for Transition of Business-Models to common Software-Tools and Optimization of
    the Model-Structure exemplified with Microsoft SharePoint 2010</i>. 20–25.
  bibtex: '@inproceedings{Lauck_Hartmann_Laroque_2012, title={Multi-Layer Architecture
    for Transition of Business-Models to common Software-Tools and Optimization of
    the Model-Structure exemplified with Microsoft SharePoint 2010}, publisher={International
    Institute of Informatics and Systemics}, author={Lauck, Sebastian and Hartmann,
    Philip and Laroque, Christoph}, year={2012}, pages={20–25} }'
  chicago: Lauck, Sebastian, Philip Hartmann, and Christoph Laroque. “Multi-Layer
    Architecture for Transition of Business-Models to Common Software-Tools and Optimization
    of the Model-Structure Exemplified with Microsoft SharePoint 2010,” 20–25. International
    Institute of Informatics and Systemics, 2012.
  ieee: S. Lauck, P. Hartmann, and C. Laroque, “Multi-Layer Architecture for Transition
    of Business-Models to common Software-Tools and Optimization of the Model-Structure
    exemplified with Microsoft SharePoint 2010,” 2012, pp. 20–25.
  mla: Lauck, Sebastian, et al. <i>Multi-Layer Architecture for Transition of Business-Models
    to Common Software-Tools and Optimization of the Model-Structure Exemplified with
    Microsoft SharePoint 2010</i>. International Institute of Informatics and Systemics,
    2012, pp. 20–25.
  short: 'S. Lauck, P. Hartmann, C. Laroque, in: International Institute of Informatics
    and Systemics, 2012, pp. 20–25.'
date_created: 2021-10-07T18:20:49Z
date_updated: 2022-01-25T18:18:33Z
department:
- _id: '671'
language:
- iso: eng
page: 20-25
publisher: International Institute of Informatics and Systemics
status: public
title: Multi-Layer Architecture for Transition of Business-Models to common Software-Tools
  and Optimization of the Model-Structure exemplified with Microsoft SharePoint 2010
type: conference
user_id: '71124'
year: '2012'
...
---
_id: '25818'
alternative_title:
- APMOD 2012
author:
- first_name: Jan-Hendrik
  full_name: Fischer, Jan-Hendrik
  last_name: Fischer
- first_name: ' Robin'
  full_name: Delius,  Robin
  last_name: Delius
- first_name: Dennis
  full_name: Horstkemper, Dennis
  last_name: Horstkemper
- first_name: ' Christoph'
  full_name: Laroque,  Christoph
  last_name: Laroque
citation:
  ama: 'Fischer J-H, Delius  Robin, Horstkemper D, Laroque  Christoph. Comparing a
    hybrid simulation &#38; optimization approach with a purely stochastic optimization
    to increase the robustness of production plans. In: ; 2012.'
  apa: Fischer, J.-H., Delius,  Robin, Horstkemper, D., &#38; Laroque,  Christoph.
    (2012). <i>Comparing a hybrid simulation &#38; optimization approach with a purely
    stochastic optimization to increase the robustness of production plans</i>.
  bibtex: '@inproceedings{Fischer_Delius_Horstkemper_Laroque_2012, title={Comparing
    a hybrid simulation &#38; optimization approach with a purely stochastic optimization
    to increase the robustness of production plans}, author={Fischer, Jan-Hendrik
    and Delius,  Robin and Horstkemper, Dennis and Laroque,  Christoph}, year={2012}
    }'
  chicago: Fischer, Jan-Hendrik,  Robin Delius, Dennis Horstkemper, and  Christoph
    Laroque. “Comparing a Hybrid Simulation &#38; Optimization Approach with a Purely
    Stochastic Optimization to Increase the Robustness of Production Plans,” 2012.
  ieee: J.-H. Fischer,  Robin Delius, D. Horstkemper, and  Christoph Laroque, “Comparing
    a hybrid simulation &#38; optimization approach with a purely stochastic optimization
    to increase the robustness of production plans,” 2012.
  mla: Fischer, Jan-Hendrik, et al. <i>Comparing a Hybrid Simulation &#38; Optimization
    Approach with a Purely Stochastic Optimization to Increase the Robustness of Production
    Plans</i>. 2012.
  short: 'J.-H. Fischer,  Robin Delius, D. Horstkemper,  Christoph Laroque, in: 2012.'
conference:
  end_date: 2012-03-30
  start_date: 2012-03-28
date_created: 2021-10-07T19:02:51Z
date_updated: 2022-01-25T18:19:26Z
department:
- _id: '671'
language:
- iso: eng
publication_status: published
status: public
title: Comparing a hybrid simulation & optimization approach with a purely stochastic
  optimization to increase the robustness of production plans
type: conference
user_id: '71124'
year: '2012'
...
---
_id: '25821'
author:
- first_name: ' Christoph '
  full_name: 'Laroque,  Christoph '
  last_name: Laroque
- first_name: 'Robin '
  full_name: 'Delius, Robin '
  last_name: Delius
- first_name: Jan-Hendrik
  full_name: Fischer, Jan-Hendrik
  last_name: Fischer
citation:
  ama: Laroque  Christoph , Delius R, Fischer J-H. Increase of robustness in production
    plans using a hybrid optimization and simulation approach. <i>International Journal
    on Advances in Systems and measurements</i>. Published online 2012.
  apa: Laroque,  Christoph , Delius, R., &#38; Fischer, J.-H. (2012). Increase of
    robustness in production plans using a hybrid optimization and simulation approach.
    <i>International Journal on Advances in Systems and Measurements</i>.
  bibtex: '@article{Laroque_Delius_Fischer_2012, title={Increase of robustness in
    production plans using a hybrid optimization and simulation approach}, journal={International
    Journal on Advances in Systems and measurements}, author={Laroque,  Christoph  and
    Delius, Robin  and Fischer, Jan-Hendrik}, year={2012} }'
  chicago: Laroque,  Christoph , Robin  Delius, and Jan-Hendrik Fischer. “Increase
    of Robustness in Production Plans Using a Hybrid Optimization and Simulation Approach.”
    <i>International Journal on Advances in Systems and Measurements</i>, 2012.
  ieee: Christoph  Laroque, R. Delius, and J.-H. Fischer, “Increase of robustness
    in production plans using a hybrid optimization and simulation approach,” <i>International
    Journal on Advances in Systems and measurements</i>, 2012.
  mla: Laroque,  Christoph , et al. “Increase of Robustness in Production Plans Using
    a Hybrid Optimization and Simulation Approach.” <i>International Journal on Advances
    in Systems and Measurements</i>, 2012.
  short: Christoph  Laroque, R. Delius, J.-H. Fischer, International Journal on Advances
    in Systems and Measurements (2012).
date_created: 2021-10-07T19:08:24Z
date_updated: 2022-01-25T18:19:35Z
department:
- _id: '671'
language:
- iso: eng
publication: International Journal on Advances in Systems and measurements
publication_status: published
status: public
title: Increase of robustness in production plans using a hybrid optimization and
  simulation approach
type: journal_article
user_id: '71124'
year: '2012'
...
---
_id: '25820'
author:
- first_name: Ekaterina
  full_name: Kaganova, Ekaterina
  last_name: Kaganova
citation:
  ama: Kaganova E. Robust solution approach to an uncertain CLSP problem. <i>Applied
    Mathematical Optimization and Modelling</i>. Published online 2012.
  apa: Kaganova, E. (2012). Robust solution approach to an uncertain CLSP problem.
    <i>Applied Mathematical Optimization and Modelling</i>.
  bibtex: '@article{Kaganova_2012, title={Robust solution approach to an uncertain
    CLSP problem}, journal={Applied Mathematical Optimization and Modelling}, author={Kaganova,
    Ekaterina}, year={2012} }'
  chicago: Kaganova, Ekaterina. “Robust Solution Approach to an Uncertain CLSP Problem.”
    <i>Applied Mathematical Optimization and Modelling</i>, 2012.
  ieee: E. Kaganova, “Robust solution approach to an uncertain CLSP problem,” <i>Applied
    Mathematical Optimization and Modelling</i>, 2012.
  mla: Kaganova, Ekaterina. “Robust Solution Approach to an Uncertain CLSP Problem.”
    <i>Applied Mathematical Optimization and Modelling</i>, 2012.
  short: E. Kaganova, Applied Mathematical Optimization and Modelling (2012).
date_created: 2021-10-07T19:05:15Z
date_updated: 2022-01-25T18:19:26Z
department:
- _id: '671'
language:
- iso: eng
publication: Applied Mathematical Optimization and Modelling
publication_status: published
status: public
title: Robust solution approach to an uncertain CLSP problem
type: journal_article
user_id: '71124'
year: '2012'
...
---
_id: '25827'
abstract:
- lang: eng
  text: "Persistent trends like quickly changing production programs, increasing customer
    individual manufacturing and Sustainable Manufacturing create complex systems
    of objectives in manufacturing control. Service-oriented manufacturing systems
    and self-optimizing manufacturing resources offer the required flexibility to
    consider these objectives in accordance with the current organizational and economical
    situation. On the downside, this increase in flexibility make the control of manufacturing
    systems more difficult and presents new challenges regarding the scheduling. To
    meet these challenges, we developed scheduling framework that supports alternative
    process plans and considers the internal states trajectories of resources. In
    order to support the user in a complex decision-making environment, evolutionary
    multi-objective optimization is used to generate a set of relevant schedules and
    an interface to select the most appropriate schedule is provided.\r\n"
author:
- first_name: Benjamin
  full_name: Kl{\, Benjamin
  last_name: Kl{\
- first_name: 'Jan-Patrick '
  full_name: 'Pater, Jan-Patrick '
  last_name: Pater
- first_name: Shinichi
  full_name: Honiden, Shinichi
  last_name: Honiden
- first_name: Wilhelm
  full_name: Dangelmaier, Wilhelm
  last_name: Dangelmaier
citation:
  ama: Kl{\ B, Pater J-P, Honiden S, Dangelmaier W. A multi-objective evolutionary
    approach to scheduling for evolving manufacturing systems. <i>Evolving Systems</i>.
    2012;3(1):31-44.
  apa: Kl{\, B., Pater, J.-P., Honiden, S., &#38; Dangelmaier, W. (2012). A multi-objective
    evolutionary approach to scheduling for evolving manufacturing systems. <i>Evolving
    Systems</i>, <i>3</i>(1), 31–44.
  bibtex: '@article{Kl{\_Pater_Honiden_Dangelmaier_2012, title={A multi-objective
    evolutionary approach to scheduling for evolving manufacturing systems}, volume={3},
    number={1}, journal={Evolving Systems}, author={Kl{\, Benjamin and Pater, Jan-Patrick  and
    Honiden, Shinichi and Dangelmaier, Wilhelm}, year={2012}, pages={31–44} }'
  chicago: 'Kl{\, Benjamin, Jan-Patrick  Pater, Shinichi Honiden, and Wilhelm Dangelmaier.
    “A Multi-Objective Evolutionary Approach to Scheduling for Evolving Manufacturing
    Systems.” <i>Evolving Systems</i> 3, no. 1 (2012): 31–44.'
  ieee: B. Kl{\, J.-P. Pater, S. Honiden, and W. Dangelmaier, “A multi-objective evolutionary
    approach to scheduling for evolving manufacturing systems,” <i>Evolving Systems</i>,
    vol. 3, no. 1, pp. 31–44, 2012.
  mla: Kl{\, Benjamin, et al. “A Multi-Objective Evolutionary Approach to Scheduling
    for Evolving Manufacturing Systems.” <i>Evolving Systems</i>, vol. 3, no. 1, 2012,
    pp. 31–44.
  short: B. Kl{\, J.-P. Pater, S. Honiden, W. Dangelmaier, Evolving Systems 3 (2012)
    31–44.
date_created: 2021-10-07T20:33:24Z
date_updated: 2022-01-25T18:20:05Z
department:
- _id: '671'
intvolume: '         3'
issue: '1'
language:
- iso: eng
page: 31-44
publication: Evolving Systems
publication_status: published
status: public
title: A multi-objective evolutionary approach to scheduling for evolving manufacturing
  systems
type: journal_article
user_id: '71124'
volume: 3
year: '2012'
...
---
_id: '11833'
abstract:
- lang: eng
  text: In this paper we propose an approach to retrieve the geometry of an acoustic
    sensor network consisting of spatially distributed microphone arrays from unconstrained
    speech input. The calibration relies on Direction of Arrival (DoA) measurements
    which do not require a clock synchronization among the sensor nodes. The calibration
    problem is formulated as a cost function optimization task, which minimizes the
    squared differences between measured and predicted observations and additionally
    avoids the existence of minima that correspond to mirrored versions of the actual
    sensor orientations. Further, outlier measurements caused by reverberation are
    mitigated by a Random Sample Consensus (RANSAC) approach. The experimental results
    show a mean positioning error of at most 25 cm even in highly reverberant environments.
author:
- first_name: Florian
  full_name: Jacob, Florian
  last_name: Jacob
- first_name: Joerg
  full_name: Schmalenstroeer, Joerg
  id: '460'
  last_name: Schmalenstroeer
- first_name: Reinhold
  full_name: Haeb-Umbach, Reinhold
  id: '242'
  last_name: Haeb-Umbach
citation:
  ama: 'Jacob F, Schmalenstroeer J, Haeb-Umbach R. Microphone Array Position Self-Calibration
    from Reverberant Speech Input. In: <i>International Workshop on Acoustic Signal
    Enhancement (IWAENC 2012)</i>. ; 2012.'
  apa: Jacob, F., Schmalenstroeer, J., &#38; Haeb-Umbach, R. (2012). Microphone Array
    Position Self-Calibration from Reverberant Speech Input. <i>International Workshop
    on Acoustic Signal Enhancement (IWAENC 2012)</i>.
  bibtex: '@inproceedings{Jacob_Schmalenstroeer_Haeb-Umbach_2012, title={Microphone
    Array Position Self-Calibration from Reverberant Speech Input}, booktitle={International
    Workshop on Acoustic Signal Enhancement (IWAENC 2012)}, author={Jacob, Florian
    and Schmalenstroeer, Joerg and Haeb-Umbach, Reinhold}, year={2012} }'
  chicago: Jacob, Florian, Joerg Schmalenstroeer, and Reinhold Haeb-Umbach. “Microphone
    Array Position Self-Calibration from Reverberant Speech Input.” In <i>International
    Workshop on Acoustic Signal Enhancement (IWAENC 2012)</i>, 2012.
  ieee: F. Jacob, J. Schmalenstroeer, and R. Haeb-Umbach, “Microphone Array Position
    Self-Calibration from Reverberant Speech Input,” 2012.
  mla: Jacob, Florian, et al. “Microphone Array Position Self-Calibration from Reverberant
    Speech Input.” <i>International Workshop on Acoustic Signal Enhancement (IWAENC
    2012)</i>, 2012.
  short: 'F. Jacob, J. Schmalenstroeer, R. Haeb-Umbach, in: International Workshop
    on Acoustic Signal Enhancement (IWAENC 2012), 2012.'
date_created: 2019-07-12T05:29:08Z
date_updated: 2023-10-26T08:10:52Z
department:
- _id: '54'
keyword:
- Unsupervised
- geometry calibration
- microphone arrays
- position self-calibration
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://groups.uni-paderborn.de/nt/pubs/2012/JaScHa12.pdf
oa: '1'
publication: International Workshop on Acoustic Signal Enhancement (IWAENC 2012)
quality_controlled: '1'
related_material:
  link:
  - description: Video
    relation: supplementary_material
    url: https://groups.uni-paderborn.de/nt/pubs/2012/Microphine_Array_Position_Self-Calibration_from_Reverberant_Speech_Input.mp4
  - description: Poster
    relation: supplementary_material
    url: https://groups.uni-paderborn.de/nt/pubs/2012/JaScHa12_Poster.pdf
  - description: Demonstrator
    relation: supplementary_material
    url: https://groups.uni-paderborn.de/nt/pubs/2012/JaScHa12_Demonstrator.pdf
status: public
title: Microphone Array Position Self-Calibration from Reverberant Speech Input
type: conference
user_id: '460'
year: '2012'
...
---
_id: '46397'
abstract:
- lang: eng
  text: In multiobjective optimization, set-based performance indicators are commonly
    used to assess the quality of a Pareto front approximation. Based on the scalarization
    obtained by these indicators, a performance comparison of multiobjective optimization
    algorithms becomes possible. The R2 and the Hypervolume (HV) indicator represent
    two recommended approaches which have shown a correlated behavior in recent empirical
    studies. Whereas the HV indicator has been comprehensively analyzed in the last
    years, almost no studies on the R2 indicator exist. In this paper, we thus perform
    a comprehensive investigation of the properties of the R2 indicator in a theoretical
    and empirical way. The influence of the number and distribution of the weight
    vectors on the optimal distribution of μ solutions is analyzed. Based on a comparative
    analysis, specific characteristics and differences of the R2 and HV indicator
    are presented.
author:
- first_name: Dimo
  full_name: Brockhoff, Dimo
  last_name: Brockhoff
- first_name: Tobias
  full_name: Wagner, Tobias
  last_name: Wagner
- first_name: Heike
  full_name: Trautmann, Heike
  id: '100740'
  last_name: Trautmann
  orcid: 0000-0002-9788-8282
citation:
  ama: 'Brockhoff D, Wagner T, Trautmann H. On the Properties of the R2 Indicator.
    In: <i>Proceedings of the 14th Annual Conference on Genetic and Evolutionary Computation</i>.
    GECCO ’12. Association for Computing Machinery; 2012:465–472. doi:<a href="https://doi.org/10.1145/2330163.2330230">10.1145/2330163.2330230</a>'
  apa: Brockhoff, D., Wagner, T., &#38; Trautmann, H. (2012). On the Properties of
    the R2 Indicator. <i>Proceedings of the 14th Annual Conference on Genetic and
    Evolutionary Computation</i>, 465–472. <a href="https://doi.org/10.1145/2330163.2330230">https://doi.org/10.1145/2330163.2330230</a>
  bibtex: '@inproceedings{Brockhoff_Wagner_Trautmann_2012, place={New York, NY, USA},
    series={GECCO ’12}, title={On the Properties of the R2 Indicator}, DOI={<a href="https://doi.org/10.1145/2330163.2330230">10.1145/2330163.2330230</a>},
    booktitle={Proceedings of the 14th Annual Conference on Genetic and Evolutionary
    Computation}, publisher={Association for Computing Machinery}, author={Brockhoff,
    Dimo and Wagner, Tobias and Trautmann, Heike}, year={2012}, pages={465–472}, collection={GECCO
    ’12} }'
  chicago: 'Brockhoff, Dimo, Tobias Wagner, and Heike Trautmann. “On the Properties
    of the R2 Indicator.” In <i>Proceedings of the 14th Annual Conference on Genetic
    and Evolutionary Computation</i>, 465–472. GECCO ’12. New York, NY, USA: Association
    for Computing Machinery, 2012. <a href="https://doi.org/10.1145/2330163.2330230">https://doi.org/10.1145/2330163.2330230</a>.'
  ieee: 'D. Brockhoff, T. Wagner, and H. Trautmann, “On the Properties of the R2 Indicator,”
    in <i>Proceedings of the 14th Annual Conference on Genetic and Evolutionary Computation</i>,
    2012, pp. 465–472, doi: <a href="https://doi.org/10.1145/2330163.2330230">10.1145/2330163.2330230</a>.'
  mla: Brockhoff, Dimo, et al. “On the Properties of the R2 Indicator.” <i>Proceedings
    of the 14th Annual Conference on Genetic and Evolutionary Computation</i>, Association
    for Computing Machinery, 2012, pp. 465–472, doi:<a href="https://doi.org/10.1145/2330163.2330230">10.1145/2330163.2330230</a>.
  short: 'D. Brockhoff, T. Wagner, H. Trautmann, in: Proceedings of the 14th Annual
    Conference on Genetic and Evolutionary Computation, Association for Computing
    Machinery, New York, NY, USA, 2012, pp. 465–472.'
date_created: 2023-08-04T15:52:42Z
date_updated: 2023-10-16T13:47:23Z
department:
- _id: '34'
- _id: '819'
doi: 10.1145/2330163.2330230
keyword:
- hypervolume indicator
- multiobjective optimization
- performance assessment
- r2 indicator
language:
- iso: eng
page: 465–472
place: New York, NY, USA
publication: Proceedings of the 14th Annual Conference on Genetic and Evolutionary
  Computation
publication_identifier:
  isbn:
  - '9781450311779'
publisher: Association for Computing Machinery
series_title: GECCO ’12
status: public
title: On the Properties of the R2 Indicator
type: conference
user_id: '15504'
year: '2012'
...
---
_id: '46396'
abstract:
- lang: eng
  text: The steady supply of new optimization methods makes the algorithm selection
    problem (ASP) an increasingly pressing and challenging task, specially for real-world
    black-box optimization problems. The introduced approach considers the ASP as
    a cost-sensitive classification task which is based on Exploratory Landscape Analysis.
    Low-level features gathered by systematic sampling of the function on the feasible
    set are used to predict a well-performing algorithm out of a given portfolio.
    Example-specific label costs are defined by the expected runtime of each candidate
    algorithm. We use one-sided support vector regression to solve this learning problem.
    The approach is illustrated by means of the optimization problems and algorithms
    of the BBOB’09/10 workshop.
author:
- first_name: Bernd
  full_name: Bischl, Bernd
  last_name: Bischl
- first_name: Olaf
  full_name: Mersmann, Olaf
  last_name: Mersmann
- first_name: Heike
  full_name: Trautmann, Heike
  id: '100740'
  last_name: Trautmann
  orcid: 0000-0002-9788-8282
- first_name: Mike
  full_name: Preuß, Mike
  last_name: Preuß
citation:
  ama: 'Bischl B, Mersmann O, Trautmann H, Preuß M. Algorithm Selection Based on Exploratory
    Landscape Analysis and Cost-Sensitive Learning. In: <i>Proceedings of the 14th
    Annual Conference on Genetic and Evolutionary Computation</i>. GECCO ’12. Association
    for Computing Machinery; 2012:313–320. doi:<a href="https://doi.org/10.1145/2330163.2330209">10.1145/2330163.2330209</a>'
  apa: Bischl, B., Mersmann, O., Trautmann, H., &#38; Preuß, M. (2012). Algorithm
    Selection Based on Exploratory Landscape Analysis and Cost-Sensitive Learning.
    <i>Proceedings of the 14th Annual Conference on Genetic and Evolutionary Computation</i>,
    313–320. <a href="https://doi.org/10.1145/2330163.2330209">https://doi.org/10.1145/2330163.2330209</a>
  bibtex: '@inproceedings{Bischl_Mersmann_Trautmann_Preuß_2012, place={New York, NY,
    USA}, series={GECCO ’12}, title={Algorithm Selection Based on Exploratory Landscape
    Analysis and Cost-Sensitive Learning}, DOI={<a href="https://doi.org/10.1145/2330163.2330209">10.1145/2330163.2330209</a>},
    booktitle={Proceedings of the 14th Annual Conference on Genetic and Evolutionary
    Computation}, publisher={Association for Computing Machinery}, author={Bischl,
    Bernd and Mersmann, Olaf and Trautmann, Heike and Preuß, Mike}, year={2012}, pages={313–320},
    collection={GECCO ’12} }'
  chicago: 'Bischl, Bernd, Olaf Mersmann, Heike Trautmann, and Mike Preuß. “Algorithm
    Selection Based on Exploratory Landscape Analysis and Cost-Sensitive Learning.”
    In <i>Proceedings of the 14th Annual Conference on Genetic and Evolutionary Computation</i>,
    313–320. GECCO ’12. New York, NY, USA: Association for Computing Machinery, 2012.
    <a href="https://doi.org/10.1145/2330163.2330209">https://doi.org/10.1145/2330163.2330209</a>.'
  ieee: 'B. Bischl, O. Mersmann, H. Trautmann, and M. Preuß, “Algorithm Selection
    Based on Exploratory Landscape Analysis and Cost-Sensitive Learning,” in <i>Proceedings
    of the 14th Annual Conference on Genetic and Evolutionary Computation</i>, 2012,
    pp. 313–320, doi: <a href="https://doi.org/10.1145/2330163.2330209">10.1145/2330163.2330209</a>.'
  mla: Bischl, Bernd, et al. “Algorithm Selection Based on Exploratory Landscape Analysis
    and Cost-Sensitive Learning.” <i>Proceedings of the 14th Annual Conference on
    Genetic and Evolutionary Computation</i>, Association for Computing Machinery,
    2012, pp. 313–320, doi:<a href="https://doi.org/10.1145/2330163.2330209">10.1145/2330163.2330209</a>.
  short: 'B. Bischl, O. Mersmann, H. Trautmann, M. Preuß, in: Proceedings of the 14th
    Annual Conference on Genetic and Evolutionary Computation, Association for Computing
    Machinery, New York, NY, USA, 2012, pp. 313–320.'
date_created: 2023-08-04T15:51:56Z
date_updated: 2023-10-16T13:48:48Z
department:
- _id: '34'
- _id: '819'
doi: 10.1145/2330163.2330209
keyword:
- machine learning
- exploratory landscape analysis
- fitness landscape
- benchmarking
- evolutionary optimization
- bbob test set
- algorithm selection
language:
- iso: eng
page: 313–320
place: New York, NY, USA
publication: Proceedings of the 14th Annual Conference on Genetic and Evolutionary
  Computation
publication_identifier:
  isbn:
  - '9781450311779'
publisher: Association for Computing Machinery
series_title: GECCO ’12
status: public
title: Algorithm Selection Based on Exploratory Landscape Analysis and Cost-Sensitive
  Learning
type: conference
user_id: '15504'
year: '2012'
...
---
_id: '46399'
abstract:
- lang: eng
  text: Meta-modeling has become a crucial tool in solving expensive optimization
    problems. Much of the work in the past has focused on finding a good regression
    method to model the fitness function. Examples include classical linear regression,
    splines, neural networks, Kriging and support vector regression. This paper specifically
    draws attention to the fact that assessing model accuracy is a crucial aspect
    in the meta-modeling framework. Resampling strategies such as cross-validation,
    subsampling, bootstrapping, and nested resampling are prominent methods for model
    validation and are systematically discussed with respect to possible pitfalls,
    shortcomings, and specific features. A survey of meta-modeling techniques within
    evolutionary optimization is provided. In addition, practical examples illustrating
    some of the pitfalls associated with model selection and performance assessment
    are presented. Finally, recommendations are given for choosing a model validation
    technique for a particular setting.
author:
- first_name: B
  full_name: Bischl, B
  last_name: Bischl
- first_name: O
  full_name: Mersmann, O
  last_name: Mersmann
- first_name: Heike
  full_name: Trautmann, Heike
  id: '100740'
  last_name: Trautmann
  orcid: 0000-0002-9788-8282
- first_name: C
  full_name: Weihs, C
  last_name: Weihs
citation:
  ama: Bischl B, Mersmann O, Trautmann H, Weihs C. Resampling Methods in Model Validation.
    <i>Evolutionary Computation Journal</i>. 2012;20(2):249–275. doi:<a href="https://doi.org/10.1162/EVCO_a_00069">10.1162/EVCO_a_00069</a>
  apa: Bischl, B., Mersmann, O., Trautmann, H., &#38; Weihs, C. (2012). Resampling
    Methods in Model Validation. <i>Evolutionary Computation Journal</i>, <i>20</i>(2),
    249–275. <a href="https://doi.org/10.1162/EVCO_a_00069">https://doi.org/10.1162/EVCO_a_00069</a>
  bibtex: '@article{Bischl_Mersmann_Trautmann_Weihs_2012, title={Resampling Methods
    in Model Validation}, volume={20}, DOI={<a href="https://doi.org/10.1162/EVCO_a_00069">10.1162/EVCO_a_00069</a>},
    number={2}, journal={Evolutionary Computation Journal}, author={Bischl, B and
    Mersmann, O and Trautmann, Heike and Weihs, C}, year={2012}, pages={249–275} }'
  chicago: 'Bischl, B, O Mersmann, Heike Trautmann, and C Weihs. “Resampling Methods
    in Model Validation.” <i>Evolutionary Computation Journal</i> 20, no. 2 (2012):
    249–275. <a href="https://doi.org/10.1162/EVCO_a_00069">https://doi.org/10.1162/EVCO_a_00069</a>.'
  ieee: 'B. Bischl, O. Mersmann, H. Trautmann, and C. Weihs, “Resampling Methods in
    Model Validation,” <i>Evolutionary Computation Journal</i>, vol. 20, no. 2, pp.
    249–275, 2012, doi: <a href="https://doi.org/10.1162/EVCO_a_00069">10.1162/EVCO_a_00069</a>.'
  mla: Bischl, B., et al. “Resampling Methods in Model Validation.” <i>Evolutionary
    Computation Journal</i>, vol. 20, no. 2, 2012, pp. 249–275, doi:<a href="https://doi.org/10.1162/EVCO_a_00069">10.1162/EVCO_a_00069</a>.
  short: B. Bischl, O. Mersmann, H. Trautmann, C. Weihs, Evolutionary Computation
    Journal 20 (2012) 249–275.
date_created: 2023-08-04T15:54:41Z
date_updated: 2023-10-16T13:53:58Z
department:
- _id: '34'
- _id: '819'
doi: 10.1162/EVCO_a_00069
intvolume: '        20'
issue: '2'
language:
- iso: eng
page: 249–275
publication: Evolutionary Computation Journal
status: public
title: Resampling Methods in Model Validation
type: journal_article
user_id: '15504'
volume: 20
year: '2012'
...
---
_id: '48890'
abstract:
- lang: eng
  text: With this paper we contribute to the understanding of the success of 2-opt
    based local search algorithms for solving the traveling salesman problem TSP.
    Although 2-opt is widely used in practice, it is hard to understand its success
    from a theoretical perspective. We take a statistical approach and examine the
    features of TSP instances that make the problem either hard or easy to solve.
    As a measure of problem difficulty for 2-opt we use the approximation ratio that
    it achieves on a given instance. Our investigations point out important features
    that make TSP instances hard or easy to be approximated by 2-opt.
author:
- first_name: Olaf
  full_name: Mersmann, Olaf
  last_name: Mersmann
- first_name: Bernd
  full_name: Bischl, Bernd
  last_name: Bischl
- first_name: Jakob
  full_name: Bossek, Jakob
  id: '102979'
  last_name: Bossek
  orcid: 0000-0002-4121-4668
- first_name: Heike
  full_name: Trautmann, Heike
  last_name: Trautmann
- first_name: Markus
  full_name: Wagner, Markus
  last_name: Wagner
- first_name: Frank
  full_name: Neumann, Frank
  last_name: Neumann
citation:
  ama: 'Mersmann O, Bischl B, Bossek J, Trautmann H, Wagner M, Neumann F. Local Search
    and the Traveling Salesman Problem: A Feature-Based Characterization of Problem
    Hardness. In: <i>Revised Selected Papers of the 6th International Conference on
    Learning and Intelligent Optimization - Volume 7219</i>. LION 6. Springer-Verlag;
    2012:115–129.'
  apa: 'Mersmann, O., Bischl, B., Bossek, J., Trautmann, H., Wagner, M., &#38; Neumann,
    F. (2012). Local Search and the Traveling Salesman Problem: A Feature-Based Characterization
    of Problem Hardness. <i>Revised Selected Papers of the 6th International Conference
    on Learning and Intelligent Optimization - Volume 7219</i>, 115–129.'
  bibtex: '@inproceedings{Mersmann_Bischl_Bossek_Trautmann_Wagner_Neumann_2012, place={Berlin,
    Heidelberg}, series={LION 6}, title={Local Search and the Traveling Salesman Problem:
    A Feature-Based Characterization of Problem Hardness}, booktitle={Revised Selected
    Papers of the 6th International Conference on Learning and Intelligent Optimization
    - Volume 7219}, publisher={Springer-Verlag}, author={Mersmann, Olaf and Bischl,
    Bernd and Bossek, Jakob and Trautmann, Heike and Wagner, Markus and Neumann, Frank},
    year={2012}, pages={115–129}, collection={LION 6} }'
  chicago: 'Mersmann, Olaf, Bernd Bischl, Jakob Bossek, Heike Trautmann, Markus Wagner,
    and Frank Neumann. “Local Search and the Traveling Salesman Problem: A Feature-Based
    Characterization of Problem Hardness.” In <i>Revised Selected Papers of the 6th
    International Conference on Learning and Intelligent Optimization - Volume 7219</i>,
    115–129. LION 6. Berlin, Heidelberg: Springer-Verlag, 2012.'
  ieee: 'O. Mersmann, B. Bischl, J. Bossek, H. Trautmann, M. Wagner, and F. Neumann,
    “Local Search and the Traveling Salesman Problem: A Feature-Based Characterization
    of Problem Hardness,” in <i>Revised Selected Papers of the 6th International Conference
    on Learning and Intelligent Optimization - Volume 7219</i>, 2012, pp. 115–129.'
  mla: 'Mersmann, Olaf, et al. “Local Search and the Traveling Salesman Problem: A
    Feature-Based Characterization of Problem Hardness.” <i>Revised Selected Papers
    of the 6th International Conference on Learning and Intelligent Optimization -
    Volume 7219</i>, Springer-Verlag, 2012, pp. 115–129.'
  short: 'O. Mersmann, B. Bischl, J. Bossek, H. Trautmann, M. Wagner, F. Neumann,
    in: Revised Selected Papers of the 6th International Conference on Learning and
    Intelligent Optimization - Volume 7219, Springer-Verlag, Berlin, Heidelberg, 2012,
    pp. 115–129.'
date_created: 2023-11-14T15:58:59Z
date_updated: 2023-12-13T10:48:58Z
department:
- _id: '819'
extern: '1'
keyword:
- 2-opt
- Classification
- Feature Selection
- MARS
- TSP
language:
- iso: eng
page: 115–129
place: Berlin, Heidelberg
publication: Revised Selected Papers of the 6th International Conference on Learning
  and Intelligent Optimization - Volume 7219
publication_identifier:
  isbn:
  - 978-3-642-34412-1
publisher: Springer-Verlag
series_title: LION 6
status: public
title: 'Local Search and the Traveling Salesman Problem: A Feature-Based Characterization
  of Problem Hardness'
type: conference
user_id: '102979'
year: '2012'
...
---
_id: '48888'
abstract:
- lang: eng
  text: With this paper we contribute to the understanding of the success of 2-opt
    based local search algorithms for solving the traveling salesman problem (TSP).
    Although 2-opt is widely used in practice, it is hard to understand its success
    from a theoretical perspective. We take a statistical approach and examine the
    features of TSP instances that make the problem either hard or easy to solve.
    As a measure of problem difficulty for 2-opt we use the approximation ratio that
    it achieves on a given instance. Our investigations point out important features
    that make TSP instances hard or easy to be approximated by 2-opt.
author:
- first_name: Olaf
  full_name: Mersmann, Olaf
  last_name: Mersmann
- first_name: Bernd
  full_name: Bischl, Bernd
  last_name: Bischl
- first_name: Jakob
  full_name: Bossek, Jakob
  id: '102979'
  last_name: Bossek
  orcid: 0000-0002-4121-4668
- first_name: Heike
  full_name: Trautmann, Heike
  last_name: Trautmann
- first_name: Markus
  full_name: Wagner, Markus
  last_name: Wagner
- first_name: Frank
  full_name: Neumann, Frank
  last_name: Neumann
citation:
  ama: 'Mersmann O, Bischl B, Bossek J, Trautmann H, Wagner M, Neumann F. Local Search
    and the Traveling Salesman Problem: A Feature-Based Characterization of Problem
    Hardness. In: <i>Learning and Intelligent Optimization</i>. Vol 7219. Springer
    Berlin Heidelberg; 2012:115–129. doi:<a href="https://doi.org/10.1007/978-3-642-34413-8_9">10.1007/978-3-642-34413-8_9</a>'
  apa: 'Mersmann, O., Bischl, B., Bossek, J., Trautmann, H., Wagner, M., &#38; Neumann,
    F. (2012). Local Search and the Traveling Salesman Problem: A Feature-Based Characterization
    of Problem Hardness. In <i>Learning and Intelligent Optimization</i> (Vol. 7219,
    pp. 115–129). Springer Berlin Heidelberg. <a href="https://doi.org/10.1007/978-3-642-34413-8_9">https://doi.org/10.1007/978-3-642-34413-8_9</a>'
  bibtex: '@inbook{Mersmann_Bischl_Bossek_Trautmann_Wagner_Neumann_2012, place={Berlin,
    Heidelberg}, title={Local Search and the Traveling Salesman Problem: A Feature-Based
    Characterization of Problem Hardness}, volume={7219}, DOI={<a href="https://doi.org/10.1007/978-3-642-34413-8_9">10.1007/978-3-642-34413-8_9</a>},
    booktitle={Learning and Intelligent Optimization}, publisher={Springer Berlin
    Heidelberg}, author={Mersmann, Olaf and Bischl, Bernd and Bossek, Jakob and Trautmann,
    Heike and Wagner, Markus and Neumann, Frank}, year={2012}, pages={115–129} }'
  chicago: 'Mersmann, Olaf, Bernd Bischl, Jakob Bossek, Heike Trautmann, Markus Wagner,
    and Frank Neumann. “Local Search and the Traveling Salesman Problem: A Feature-Based
    Characterization of Problem Hardness.” In <i>Learning and Intelligent Optimization</i>,
    7219:115–129. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. <a href="https://doi.org/10.1007/978-3-642-34413-8_9">https://doi.org/10.1007/978-3-642-34413-8_9</a>.'
  ieee: 'O. Mersmann, B. Bischl, J. Bossek, H. Trautmann, M. Wagner, and F. Neumann,
    “Local Search and the Traveling Salesman Problem: A Feature-Based Characterization
    of Problem Hardness,” in <i>Learning and Intelligent Optimization</i>, vol. 7219,
    Berlin, Heidelberg: Springer Berlin Heidelberg, 2012, pp. 115–129.'
  mla: 'Mersmann, Olaf, et al. “Local Search and the Traveling Salesman Problem: A
    Feature-Based Characterization of Problem Hardness.” <i>Learning and Intelligent
    Optimization</i>, vol. 7219, Springer Berlin Heidelberg, 2012, pp. 115–129, doi:<a
    href="https://doi.org/10.1007/978-3-642-34413-8_9">10.1007/978-3-642-34413-8_9</a>.'
  short: 'O. Mersmann, B. Bischl, J. Bossek, H. Trautmann, M. Wagner, F. Neumann,
    in: Learning and Intelligent Optimization, Springer Berlin Heidelberg, Berlin,
    Heidelberg, 2012, pp. 115–129.'
date_created: 2023-11-14T15:58:59Z
date_updated: 2023-12-13T10:49:15Z
department:
- _id: '819'
doi: 10.1007/978-3-642-34413-8_9
extern: '1'
intvolume: '      7219'
language:
- iso: eng
page: 115–129
place: Berlin, Heidelberg
publication: Learning and Intelligent Optimization
publication_identifier:
  isbn:
  - 978-3-642-34412-1 978-3-642-34413-8
publisher: Springer Berlin Heidelberg
status: public
title: 'Local Search and the Traveling Salesman Problem: A Feature-Based Characterization
  of Problem Hardness'
type: book_chapter
user_id: '102979'
volume: 7219
year: '2012'
...
---
_id: '49699'
author:
- first_name: Christoph
  full_name: Jacke, Christoph
  id: '20747'
  last_name: Jacke
citation:
  ama: 'Jacke C. Der Club „Gleis 22". 25 Jahre andere Räume, andere Musiken, Kommunikation
    und Kreativität. In: Skroblin D, Dietrich F, eds. <i>GLEIS 22 - Fünfundzwanzig
    Jahre Konzerte.</i> Oktober Verlag; 2012:6-8.'
  apa: Jacke, C. (2012). Der Club „Gleis 22". 25 Jahre andere Räume, andere Musiken,
    Kommunikation und Kreativität. In D. Skroblin &#38; F. Dietrich (Eds.), <i>GLEIS
    22 - Fünfundzwanzig Jahre Konzerte.</i> (pp. 6–8). Oktober Verlag.
  bibtex: '@inbook{Jacke_2012, place={Münster}, title={Der Club „Gleis 22". 25 Jahre
    andere Räume, andere Musiken, Kommunikation und Kreativität.}, booktitle={GLEIS
    22 - Fünfundzwanzig Jahre Konzerte.}, publisher={Oktober Verlag}, author={Jacke,
    Christoph}, editor={Skroblin, David and Dietrich, Frank}, year={2012}, pages={6–8}
    }'
  chicago: 'Jacke, Christoph. “Der Club „Gleis 22". 25 Jahre andere Räume, andere
    Musiken, Kommunikation und Kreativität.” In <i>GLEIS 22 - Fünfundzwanzig Jahre
    Konzerte.</i>, edited by David Skroblin and Frank Dietrich, 6–8. Münster: Oktober
    Verlag, 2012.'
  ieee: 'C. Jacke, “Der Club „Gleis 22". 25 Jahre andere Räume, andere Musiken, Kommunikation
    und Kreativität.,” in <i>GLEIS 22 - Fünfundzwanzig Jahre Konzerte.</i>, D. Skroblin
    and F. Dietrich, Eds. Münster: Oktober Verlag, 2012, pp. 6–8.'
  mla: Jacke, Christoph. “Der Club „Gleis 22". 25 Jahre andere Räume, andere Musiken,
    Kommunikation und Kreativität.” <i>GLEIS 22 - Fünfundzwanzig Jahre Konzerte.</i>,
    edited by David Skroblin and Frank Dietrich, Oktober Verlag, 2012, pp. 6–8.
  short: 'C. Jacke, in: D. Skroblin, F. Dietrich (Eds.), GLEIS 22 - Fünfundzwanzig
    Jahre Konzerte., Oktober Verlag, Münster, 2012, pp. 6–8.'
date_created: 2023-12-15T12:23:02Z
date_updated: 2023-12-15T12:23:09Z
department:
- _id: '607'
editor:
- first_name: David
  full_name: Skroblin, David
  last_name: Skroblin
- first_name: Frank
  full_name: Dietrich, Frank
  last_name: Dietrich
language:
- iso: ger
page: 6-8
place: Münster
publication: GLEIS 22 - Fünfundzwanzig Jahre Konzerte.
publisher: Oktober Verlag
status: public
title: Der Club „Gleis 22". 25 Jahre andere Räume, andere Musiken, Kommunikation und
  Kreativität.
type: book_chapter
user_id: '90934'
year: '2012'
...
---
_id: '46398'
abstract:
- lang: eng
  text: With this paper we contribute to the understanding of the success of 2-opt
    based local search algorithms for solving the traveling salesman problem (TSP).
    Although 2-opt is widely used in practice, it is hard to understand its success
    from a theoretical perspective. We take a statistical approach and examine the
    features of TSP instances that make the problem either hard or easy to solve.
    As a measure of problem difficulty for 2-opt we use the approximation ratio that
    it achieves on a given instance. Our investigations point out important features
    that make TSP instances hard or easy to be approximated by 2-opt.
author:
- first_name: Olaf
  full_name: Mersmann, Olaf
  last_name: Mersmann
- first_name: Bernd
  full_name: Bischl, Bernd
  last_name: Bischl
- first_name: Jakob
  full_name: Bossek, Jakob
  id: '102979'
  last_name: Bossek
  orcid: 0000-0002-4121-4668
- first_name: Heike
  full_name: Trautmann, Heike
  id: '100740'
  last_name: Trautmann
  orcid: 0000-0002-9788-8282
- first_name: Markus
  full_name: Wagner, Markus
  last_name: Wagner
- first_name: Frank
  full_name: Neumann, Frank
  last_name: Neumann
citation:
  ama: 'Mersmann O, Bischl B, Bossek J, Trautmann H, Wagner M, Neumann F. Local Search
    and the Traveling Salesman Problem: A Feature-Based Characterization of Problem
    Hardness. In: Hamadi Y, Schoenauer M, eds. <i>Learning and Intelligent Optimization</i>.
    Springer Berlin Heidelberg; 2012:115–129. doi:<a href="https://doi.org/10.1007/978-3-642-34413-8_9">https://doi.org/10.1007/978-3-642-34413-8_9</a>'
  apa: 'Mersmann, O., Bischl, B., Bossek, J., Trautmann, H., Wagner, M., &#38; Neumann,
    F. (2012). Local Search and the Traveling Salesman Problem: A Feature-Based Characterization
    of Problem Hardness. In Y. Hamadi &#38; M. Schoenauer (Eds.), <i>Learning and
    Intelligent Optimization</i> (pp. 115–129). Springer Berlin Heidelberg. <a href="https://doi.org/10.1007/978-3-642-34413-8_9">https://doi.org/10.1007/978-3-642-34413-8_9</a>'
  bibtex: '@inproceedings{Mersmann_Bischl_Bossek_Trautmann_Wagner_Neumann_2012, place={Berlin,
    Heidelberg}, title={Local Search and the Traveling Salesman Problem: A Feature-Based
    Characterization of Problem Hardness}, DOI={<a href="https://doi.org/10.1007/978-3-642-34413-8_9">https://doi.org/10.1007/978-3-642-34413-8_9</a>},
    booktitle={Learning and Intelligent Optimization}, publisher={Springer Berlin
    Heidelberg}, author={Mersmann, Olaf and Bischl, Bernd and Bossek, Jakob and Trautmann,
    Heike and Wagner, Markus and Neumann, Frank}, editor={Hamadi, Youssef and Schoenauer,
    Marc}, year={2012}, pages={115–129} }'
  chicago: 'Mersmann, Olaf, Bernd Bischl, Jakob Bossek, Heike Trautmann, Markus Wagner,
    and Frank Neumann. “Local Search and the Traveling Salesman Problem: A Feature-Based
    Characterization of Problem Hardness.” In <i>Learning and Intelligent Optimization</i>,
    edited by Youssef Hamadi and Marc Schoenauer, 115–129. Berlin, Heidelberg: Springer
    Berlin Heidelberg, 2012. <a href="https://doi.org/10.1007/978-3-642-34413-8_9">https://doi.org/10.1007/978-3-642-34413-8_9</a>.'
  ieee: 'O. Mersmann, B. Bischl, J. Bossek, H. Trautmann, M. Wagner, and F. Neumann,
    “Local Search and the Traveling Salesman Problem: A Feature-Based Characterization
    of Problem Hardness,” in <i>Learning and Intelligent Optimization</i>, 2012, pp.
    115–129, doi: <a href="https://doi.org/10.1007/978-3-642-34413-8_9">https://doi.org/10.1007/978-3-642-34413-8_9</a>.'
  mla: 'Mersmann, Olaf, et al. “Local Search and the Traveling Salesman Problem: A
    Feature-Based Characterization of Problem Hardness.” <i>Learning and Intelligent
    Optimization</i>, edited by Youssef Hamadi and Marc Schoenauer, Springer Berlin
    Heidelberg, 2012, pp. 115–129, doi:<a href="https://doi.org/10.1007/978-3-642-34413-8_9">https://doi.org/10.1007/978-3-642-34413-8_9</a>.'
  short: 'O. Mersmann, B. Bischl, J. Bossek, H. Trautmann, M. Wagner, F. Neumann,
    in: Y. Hamadi, M. Schoenauer (Eds.), Learning and Intelligent Optimization, Springer
    Berlin Heidelberg, Berlin, Heidelberg, 2012, pp. 115–129.'
date_created: 2023-08-04T15:53:33Z
date_updated: 2024-06-10T11:57:32Z
department:
- _id: '34'
- _id: '819'
doi: https://doi.org/10.1007/978-3-642-34413-8_9
editor:
- first_name: Youssef
  full_name: Hamadi, Youssef
  last_name: Hamadi
- first_name: Marc
  full_name: Schoenauer, Marc
  last_name: Schoenauer
language:
- iso: eng
page: 115–129
place: Berlin, Heidelberg
publication: Learning and Intelligent Optimization
publication_identifier:
  isbn:
  - 978-3-642-34413-8
publisher: Springer Berlin Heidelberg
status: public
title: 'Local Search and the Traveling Salesman Problem: A Feature-Based Characterization
  of Problem Hardness'
type: conference
user_id: '15504'
year: '2012'
...
---
_id: '54937'
abstract:
- lang: eng
  text: 'Purpose: The epithelial sodium channel (ENaC) is typically expressed in sodium-absorbing
    epithelia. Several reports suggest that ENaC is also expressed in ocular tissues
    and may play a role in aqueous humor secretion and glaucoma. However, the precise
    localization of ENaC in the human eye is still unclear. Here, the authors studied
    ENaC expression in 12 normal human donor eyes and in six eyes of patients with
    glaucoma. Methods: Quantitative real-time PCR was used to investigate the expression
    of $\alpha$-, $\beta$-, $\gamma$-, and $\delta$-ENaC transcripts in ocular tissues.
    In addition, the authors performed immunohistochemical studies using recently
    generated antibodies against human $\beta$- and $\gamma$-ENaC. Results: At the
    mRNA level, all four ENaC subunits were found to be expressed in a wide range
    of ocular tissues from normal and glaucomatous human eyes, with the cornea, ciliary
    body, iris, and retina showing the highest expression levels. At the protein level,
    $\beta$- and $\gamma$-ENaC subunits showed distinct distribution patterns and
    could be immunolocalized primarily to the cell membranes of epithelial cells of
    the cornea and to the conjunctiva, iris, ciliary body, lens, and retinal pigment
    epithelium but also to vascular endothelial cells, smooth muscle cells, stromal
    cells, and retinal neurons. The authors found no altered mRNA level of any subunit
    in glaucomatous eyes. Conclusions: All four ENaC subunits ($\alpha$$\beta$$\gamma$$\delta$)
    are expressed in the normal human eye, with distinct localization of subunits
    possibly reflecting different functional states of the channel. The (patho-)physiological
    roles of ENaC in the various localizations in the eye remain to be determined.'
author:
- first_name: Bettina
  full_name: Krueger, Bettina
  id: '49428'
  last_name: Krueger
  orcid: 0000-0001-5351-1785
- first_name: Ursula
  full_name: Schlötzer-Schrehardt, Ursula
  last_name: Schlötzer-Schrehardt
- first_name: Silke
  full_name: Haerteis, Silke
  last_name: Haerteis
- first_name: Matthias
  full_name: Zenkel, Matthias
  last_name: Zenkel
- first_name: Verena E.
  full_name: Chankiewitz, Verena E.
  last_name: Chankiewitz
- first_name: Kerstin U.
  full_name: Amann, Kerstin U.
  last_name: Amann
- first_name: Friedrich E.
  full_name: Kruse, Friedrich E.
  last_name: Kruse
- first_name: Christoph
  full_name: Korbmacher, Christoph
  last_name: Korbmacher
citation:
  ama: Krueger B, Schlötzer-Schrehardt U, Haerteis S, et al. Four Subunits ($\alpha$$\beta$$\gamma$$\delta$)
    of the Epithelial Sodium Channel (ENaC) Are Expressed in the Human Eye in Various
    Locations. <i>Investigative Opthalmology &#38; Visual Science</i>. 2012;53(2):596–604.
    doi:<a href="https://doi.org/10.1167/iovs.11-8581">10.1167/iovs.11-8581</a>
  apa: Krueger, B., Schlötzer-Schrehardt, U., Haerteis, S., Zenkel, M., Chankiewitz,
    V. E., Amann, K. U., Kruse, F. E., &#38; Korbmacher, C. (2012). Four Subunits
    ($\alpha$$\beta$$\gamma$$\delta$) of the Epithelial Sodium Channel (ENaC) Are
    Expressed in the Human Eye in Various Locations. <i>Investigative Opthalmology
    &#38; Visual Science</i>, <i>53</i>(2), 596–604. <a href="https://doi.org/10.1167/iovs.11-8581">https://doi.org/10.1167/iovs.11-8581</a>
  bibtex: '@article{Krueger_Schlötzer-Schrehardt_Haerteis_Zenkel_Chankiewitz_Amann_Kruse_Korbmacher_2012,
    title={Four Subunits ($\alpha$$\beta$$\gamma$$\delta$) of the Epithelial Sodium
    Channel (ENaC) Are Expressed in the Human Eye in Various Locations}, volume={53},
    DOI={<a href="https://doi.org/10.1167/iovs.11-8581">10.1167/iovs.11-8581</a>},
    number={2}, journal={Investigative Opthalmology &#38; Visual Science}, publisher={Association
    for Research in Vision and Ophthalmology (ARVO)}, author={Krueger, Bettina and
    Schlötzer-Schrehardt, Ursula and Haerteis, Silke and Zenkel, Matthias and Chankiewitz,
    Verena E. and Amann, Kerstin U. and Kruse, Friedrich E. and Korbmacher, Christoph},
    year={2012}, pages={596–604} }'
  chicago: 'Krueger, Bettina, Ursula Schlötzer-Schrehardt, Silke Haerteis, Matthias
    Zenkel, Verena E. Chankiewitz, Kerstin U. Amann, Friedrich E. Kruse, and Christoph
    Korbmacher. “Four Subunits ($\alpha$$\beta$$\gamma$$\delta$) of the Epithelial
    Sodium Channel (ENaC) Are Expressed in the Human Eye in Various Locations.” <i>Investigative
    Opthalmology &#38; Visual Science</i> 53, no. 2 (2012): 596–604. <a href="https://doi.org/10.1167/iovs.11-8581">https://doi.org/10.1167/iovs.11-8581</a>.'
  ieee: 'B. Krueger <i>et al.</i>, “Four Subunits ($\alpha$$\beta$$\gamma$$\delta$)
    of the Epithelial Sodium Channel (ENaC) Are Expressed in the Human Eye in Various
    Locations,” <i>Investigative Opthalmology &#38; Visual Science</i>, vol. 53, no.
    2, pp. 596–604, 2012, doi: <a href="https://doi.org/10.1167/iovs.11-8581">10.1167/iovs.11-8581</a>.'
  mla: Krueger, Bettina, et al. “Four Subunits ($\alpha$$\beta$$\gamma$$\delta$) of
    the Epithelial Sodium Channel (ENaC) Are Expressed in the Human Eye in Various
    Locations.” <i>Investigative Opthalmology &#38; Visual Science</i>, vol. 53, no.
    2, Association for Research in Vision and Ophthalmology (ARVO), 2012, pp. 596–604,
    doi:<a href="https://doi.org/10.1167/iovs.11-8581">10.1167/iovs.11-8581</a>.
  short: B. Krueger, U. Schlötzer-Schrehardt, S. Haerteis, M. Zenkel, V.E. Chankiewitz,
    K.U. Amann, F.E. Kruse, C. Korbmacher, Investigative Opthalmology &#38; Visual
    Science 53 (2012) 596–604.
date_created: 2024-06-30T13:51:35Z
date_updated: 2024-06-30T13:52:14Z
department:
- _id: '35'
- _id: '22'
doi: 10.1167/iovs.11-8581
intvolume: '        53'
issue: '2'
language:
- iso: eng
page: 596–604
publication: Investigative Opthalmology & Visual Science
publisher: Association for Research in Vision and Ophthalmology (ARVO)
status: public
title: Four Subunits ($\alpha$$\beta$$\gamma$$\delta$) of the Epithelial Sodium Channel
  (ENaC) Are Expressed in the Human Eye in Various Locations
type: journal_article
user_id: '49428'
volume: 53
year: '2012'
...
---
_id: '54930'
abstract:
- lang: eng
  text: 'Background: Increased expression of the pro-fibrotic protein connective tissue
    growth factor (CTGF) has been detected in injured kidneys and elevated urinary
    levels of CTGF are discussed as prognostic marker of chronic kidney disease. There
    is evidence that epithelial cells lining the renal tubular system contribute to
    uptake and secretion of CTGF. However, the role of different types of tubular
    epithelial cells in these processes so far has not been addressed in primary cultures
    of human cells. Results: Tubular epithelial cells of proximal and distal origin
    were isolated from human kidneys and cultured as polarized cells in insert wells.
    The pro-fibrotic stimuli lysophosphatidic acid (LPA) and transforming growth factor
    $\beta$ (TGF-$\beta$) were used to induce CTGF secretion.LPA activated CTGF secretion
    in proximal tubular cells when applied from either the apical or the basolateral
    side as shown by immunocytochemistry. CTGF was secreted exclusively to the apical
    side. Signaling pathways activated by LPA included MAP kinase and Rho kinase signaling.
    TGF-$\beta$ applied from either side also stimulated CTGF secretion primarily
    to the apical side with little basolateral release.Interestingly, TGF-$\beta$
    activation induced different signaling pathways depending on the side of TGF-$\beta$
    application. Smad signaling was almost exclusively activated from the basolateral
    side most prominently in cells of distal origin. Only part of these cells also
    synthesized CTGF indicating that Smad activation alone was not sufficient for
    CTGF induction. MAP kinases were involved in apical TGF-$\beta$-mediated activation
    of CTGF synthesis in proximal cells and a subset of epithelial cells of distal
    origin. This subpopulation of distal tubular cells was also able to internalize
    recombinant apical CTGF, in addition to proximal cells which were the main cells
    to take up exogenous CTGF. Conclusions: Analysis of polarized human primary renal
    epithelial cells in a transwell system shows that vectorial secretion of the pro-fibrotic
    protein CTGF depends on the cell type, the stimulus and the signaling pathway
    activated. In all conditions, CTGF was secreted mainly to the apical side upon
    TGF-$\beta$ and LPA treatment and therefore, likely contributes to increased urinary
    CTGF levels in vivo. Moreover, CTGF secreted basolaterally may be active as paracrine
    pro-fibrotic mediator.'
author:
- first_name: Jonathan
  full_name: Zuehlke, Jonathan
  last_name: Zuehlke
- first_name: Astrid
  full_name: Ebenau, Astrid
  last_name: Ebenau
- first_name: Bettina
  full_name: Krueger, Bettina
  id: '49428'
  last_name: Krueger
  orcid: 0000-0001-5351-1785
- first_name: Margarete
  full_name: Goppelt-Struebe, Margarete
  last_name: Goppelt-Struebe
citation:
  ama: Zuehlke J, Ebenau A, Krueger B, Goppelt-Struebe M. Vectorial secretion of CTGF
    as a cell-type specific response to LPA and TGF-$\beta$ in human tubular epithelial
    cells. <i>Cell Communication and Signaling</i>. 2012;10(1). doi:<a href="https://doi.org/10.1186/1478-811x-10-25">10.1186/1478-811x-10-25</a>
  apa: Zuehlke, J., Ebenau, A., Krueger, B., &#38; Goppelt-Struebe, M. (2012). Vectorial
    secretion of CTGF as a cell-type specific response to LPA and TGF-$\beta$ in human
    tubular epithelial cells. <i>Cell Communication and Signaling</i>, <i>10</i>(1).
    <a href="https://doi.org/10.1186/1478-811x-10-25">https://doi.org/10.1186/1478-811x-10-25</a>
  bibtex: '@article{Zuehlke_Ebenau_Krueger_Goppelt-Struebe_2012, title={Vectorial
    secretion of CTGF as a cell-type specific response to LPA and TGF-$\beta$ in human
    tubular epithelial cells}, volume={10}, DOI={<a href="https://doi.org/10.1186/1478-811x-10-25">10.1186/1478-811x-10-25</a>},
    number={1}, journal={Cell Communication and Signaling}, publisher={Springer},
    author={Zuehlke, Jonathan and Ebenau, Astrid and Krueger, Bettina and Goppelt-Struebe,
    Margarete}, year={2012} }'
  chicago: Zuehlke, Jonathan, Astrid Ebenau, Bettina Krueger, and Margarete Goppelt-Struebe.
    “Vectorial Secretion of CTGF as a Cell-Type Specific Response to LPA and TGF-$\beta$
    in Human Tubular Epithelial Cells.” <i>Cell Communication and Signaling</i> 10,
    no. 1 (2012). <a href="https://doi.org/10.1186/1478-811x-10-25">https://doi.org/10.1186/1478-811x-10-25</a>.
  ieee: 'J. Zuehlke, A. Ebenau, B. Krueger, and M. Goppelt-Struebe, “Vectorial secretion
    of CTGF as a cell-type specific response to LPA and TGF-$\beta$ in human tubular
    epithelial cells,” <i>Cell Communication and Signaling</i>, vol. 10, no. 1, 2012,
    doi: <a href="https://doi.org/10.1186/1478-811x-10-25">10.1186/1478-811x-10-25</a>.'
  mla: Zuehlke, Jonathan, et al. “Vectorial Secretion of CTGF as a Cell-Type Specific
    Response to LPA and TGF-$\beta$ in Human Tubular Epithelial Cells.” <i>Cell Communication
    and Signaling</i>, vol. 10, no. 1, Springer, 2012, doi:<a href="https://doi.org/10.1186/1478-811x-10-25">10.1186/1478-811x-10-25</a>.
  short: J. Zuehlke, A. Ebenau, B. Krueger, M. Goppelt-Struebe, Cell Communication
    and Signaling 10 (2012).
date_created: 2024-06-30T13:45:36Z
date_updated: 2024-06-30T13:45:48Z
department:
- _id: '35'
- _id: '22'
doi: 10.1186/1478-811x-10-25
intvolume: '        10'
issue: '1'
language:
- iso: eng
publication: Cell Communication and Signaling
publisher: Springer
status: public
title: Vectorial secretion of CTGF as a cell-type specific response to LPA and TGF-$\beta$
  in human tubular epithelial cells
type: journal_article
user_id: '49428'
volume: 10
year: '2012'
...
---
_id: '54934'
abstract:
- lang: eng
  text: Aldosterone is thought to be the main hormone to stimulate the epithelial
    sodium channel (ENaC) in the aldosterone-sensitive distal nephron (ASDN) comprising
    the late distal convoluted tubule (DCT2), the connecting tubule (CNT) and the
    entire collecting duct (CD). There is immunohistochemical evidence for an axial
    gradient of ENaC expression along the ASDN with highest expression in the DCT2
    and CNT. However, most of our knowledge about renal ENaC function stems from studies
    in the cortical collecting duct (CCD). Here we investigated ENaC function in the
    transition zone of DCT2/CNT or CNT/CCD microdissected from mice maintained on
    different sodium diets to vary plasma aldosterone levels. Single-channel recordings
    demonstrated amiloride-sensitive Na(+) channels in DCT2/CNT with biophysical properties
    typical for ENaC previously described in CNT/CCD. In animals maintained on a standard
    salt diet, the average ENaC-mediated whole cell current ($\Delta$I(ami)) was higher
    in DCT2/CNT than in CNT/CCD. A low salt diet increased $\Delta$I(ami) in CNT/CCD
    but had little effect on $\Delta$I(ami) in DCT2/CNT. To investigate whether aldosterone
    is necessary for ENaC activity in the DCT2/CNT, we used aldosterone synthase knockout
    (AS(-/-)) mice that lack aldosterone. In CNT/CCD of AS(-/-) mice, $\Delta$I(ami)
    was lower than that in wild-type (WT) animals and was not stimulated by a low
    salt diet. In contrast, in DCT2/CNT of AS(-/-) mice, $\Delta$I(ami) was similar
    to that in DCT2/CNT of WT animals both on a standard and on a low salt diet. We
    conclude that ENaC function in the DCT2/CNT is largely independent of aldosterone
    which is in contrast to its known aldosterone sensitivity in CNT/CCD.
author:
- first_name: Viatcheslav
  full_name: Nesterov, Viatcheslav
  last_name: Nesterov
- first_name: Anke
  full_name: Dahlmann, Anke
  last_name: Dahlmann
- first_name: Bettina
  full_name: Krueger, Bettina
  id: '49428'
  last_name: Krueger
  orcid: 0000-0001-5351-1785
- first_name: Marko
  full_name: Bertog, Marko
  last_name: Bertog
- first_name: Johannes
  full_name: Loffing, Johannes
  last_name: Loffing
- first_name: Christoph
  full_name: Korbmacher, Christoph
  last_name: Korbmacher
citation:
  ama: Nesterov V, Dahlmann A, Krueger B, Bertog M, Loffing J, Korbmacher C. Aldosterone-dependent
    and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal
    nephron. <i>American Journal of Physiology-Renal Physiology</i>. 2012;303(9):F1289–F1299.
    doi:<a href="https://doi.org/10.1152/ajprenal.00247.2012">10.1152/ajprenal.00247.2012</a>
  apa: Nesterov, V., Dahlmann, A., Krueger, B., Bertog, M., Loffing, J., &#38; Korbmacher,
    C. (2012). Aldosterone-dependent and -independent regulation of the epithelial
    sodium channel (ENaC) in mouse distal nephron. <i>American Journal of Physiology-Renal
    Physiology</i>, <i>303</i>(9), F1289–F1299. <a href="https://doi.org/10.1152/ajprenal.00247.2012">https://doi.org/10.1152/ajprenal.00247.2012</a>
  bibtex: '@article{Nesterov_Dahlmann_Krueger_Bertog_Loffing_Korbmacher_2012, title={Aldosterone-dependent
    and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal
    nephron}, volume={303}, DOI={<a href="https://doi.org/10.1152/ajprenal.00247.2012">10.1152/ajprenal.00247.2012</a>},
    number={9}, journal={American Journal of Physiology-Renal Physiology}, publisher={American
    Physiological Society}, author={Nesterov, Viatcheslav and Dahlmann, Anke and Krueger,
    Bettina and Bertog, Marko and Loffing, Johannes and Korbmacher, Christoph}, year={2012},
    pages={F1289–F1299} }'
  chicago: 'Nesterov, Viatcheslav, Anke Dahlmann, Bettina Krueger, Marko Bertog, Johannes
    Loffing, and Christoph Korbmacher. “Aldosterone-Dependent and -Independent Regulation
    of the Epithelial Sodium Channel (ENaC) in Mouse Distal Nephron.” <i>American
    Journal of Physiology-Renal Physiology</i> 303, no. 9 (2012): F1289–F1299. <a
    href="https://doi.org/10.1152/ajprenal.00247.2012">https://doi.org/10.1152/ajprenal.00247.2012</a>.'
  ieee: 'V. Nesterov, A. Dahlmann, B. Krueger, M. Bertog, J. Loffing, and C. Korbmacher,
    “Aldosterone-dependent and -independent regulation of the epithelial sodium channel
    (ENaC) in mouse distal nephron,” <i>American Journal of Physiology-Renal Physiology</i>,
    vol. 303, no. 9, pp. F1289–F1299, 2012, doi: <a href="https://doi.org/10.1152/ajprenal.00247.2012">10.1152/ajprenal.00247.2012</a>.'
  mla: Nesterov, Viatcheslav, et al. “Aldosterone-Dependent and -Independent Regulation
    of the Epithelial Sodium Channel (ENaC) in Mouse Distal Nephron.” <i>American
    Journal of Physiology-Renal Physiology</i>, vol. 303, no. 9, American Physiological
    Society, 2012, pp. F1289–F1299, doi:<a href="https://doi.org/10.1152/ajprenal.00247.2012">10.1152/ajprenal.00247.2012</a>.
  short: V. Nesterov, A. Dahlmann, B. Krueger, M. Bertog, J. Loffing, C. Korbmacher,
    American Journal of Physiology-Renal Physiology 303 (2012) F1289–F1299.
date_created: 2024-06-30T13:49:18Z
date_updated: 2024-06-30T13:49:30Z
department:
- _id: '35'
- _id: '22'
doi: 10.1152/ajprenal.00247.2012
intvolume: '       303'
issue: '9'
language:
- iso: eng
page: F1289–F1299
publication: American Journal of Physiology-Renal Physiology
publisher: American Physiological Society
status: public
title: Aldosterone-dependent and -independent regulation of the epithelial sodium
  channel (ENaC) in mouse distal nephron
type: journal_article
user_id: '49428'
volume: 303
year: '2012'
...
---
_id: '54939'
abstract:
- lang: eng
  text: 'Background: Renal tubular epithelial cells of proximal and distal origin
    differ markedly in their physiological functions. Therefore, we hypothesized that
    they also differ in their capacity to undergo epithelial to mesenchymal alterations.
    Results: We used cultures of freshly isolated primary human tubular cells. To
    distinguish cells of different tubular origin we took advantage of the fact that
    human proximal epithelial cells uniquely express N-cadherin instead of E-cadherin
    as major cell-cell adhesion molecule. To provoke mesenchymal alteration we treated
    these cocultures with TGF-$\beta$ for up to 6 days. Within this time period, the
    morphology of distal tubular cells was barely altered. In contrast to tubular
    cell lines, E-cadherin was not down-regulated by TGF-$\beta$, even though TGF-$\beta$
    signal transduction was initiated as demonstrated by nuclear localization of Smad2/3.
    Analysis of transcription factors and miRNAs possibly involved in E-cadherin regulation
    revealed high levels of miRNAs of the miR200-family, which may contribute to the
    stability of E-cadherin expression in human distal tubular epithelial cells. By
    contrast, proximal tubular epithelial cells altered their phenotype when treated
    with TGF-$\beta$. They became elongated and formed three-dimensional structures.
    Rho-kinases were identified as modulators of TGF-$\beta$-induced morphological
    alterations. Non-specific inhibition of Rho-kinases resulted in stabilization
    of the epithelial phenotype, while partial effects were observed upon downregulation
    of Rho-kinase isoforms ROCK1 and ROCK2. The distinct reactivity of proximal and
    distal cells was retained when the cells were cultured as polarized cells. Conclusions:
    Interference with Rho-kinase signaling provides a target to counteract TGF-$\beta$-mediated
    mesenchymal alterations of epithelial cells, particularly in proximal tubular
    epithelial cells. Furthermore, primary distal tubular cells differed from cell
    lines by their high phenotypic stability which included constant expression of
    E-cadherin. Our cell culture system of primary epithelial cells is thus suitable
    to understand and modulate cellular remodeling processes of distinct tubular cells
    relevant for human renal disease.'
author:
- first_name: Christof
  full_name: Keller, Christof
  last_name: Keller
- first_name: Sven
  full_name: Kroening, Sven
  last_name: Kroening
- first_name: Jonathan
  full_name: Zuehlke, Jonathan
  last_name: Zuehlke
- first_name: Frank
  full_name: Kunath, Frank
  last_name: Kunath
- first_name: Bettina
  full_name: Krueger, Bettina
  id: '49428'
  last_name: Krueger
  orcid: 0000-0001-5351-1785
- first_name: Margarete
  full_name: Goppelt-Struebe, Margarete
  last_name: Goppelt-Struebe
citation:
  ama: Keller C, Kroening S, Zuehlke J, Kunath F, Krueger B, Goppelt-Struebe M. Distinct
    Mesenchymal Alterations in N-Cadherin and E-Cadherin Positive Primary Renal Epithelial
    Cells. <i>PLOS ONE</i>. 2012;7(8):e43584. doi:<a href="https://doi.org/10.1371/journal.pone.0043584">10.1371/journal.pone.0043584</a>
  apa: Keller, C., Kroening, S., Zuehlke, J., Kunath, F., Krueger, B., &#38; Goppelt-Struebe,
    M. (2012). Distinct Mesenchymal Alterations in N-Cadherin and E-Cadherin Positive
    Primary Renal Epithelial Cells. <i>PLOS ONE</i>, <i>7</i>(8), e43584. <a href="https://doi.org/10.1371/journal.pone.0043584">https://doi.org/10.1371/journal.pone.0043584</a>
  bibtex: '@article{Keller_Kroening_Zuehlke_Kunath_Krueger_Goppelt-Struebe_2012, title={Distinct
    Mesenchymal Alterations in N-Cadherin and E-Cadherin Positive Primary Renal Epithelial
    Cells}, volume={7}, DOI={<a href="https://doi.org/10.1371/journal.pone.0043584">10.1371/journal.pone.0043584</a>},
    number={8}, journal={PLOS ONE}, publisher={Public Library of Science}, author={Keller,
    Christof and Kroening, Sven and Zuehlke, Jonathan and Kunath, Frank and Krueger,
    Bettina and Goppelt-Struebe, Margarete}, year={2012}, pages={e43584} }'
  chicago: 'Keller, Christof, Sven Kroening, Jonathan Zuehlke, Frank Kunath, Bettina
    Krueger, and Margarete Goppelt-Struebe. “Distinct Mesenchymal Alterations in N-Cadherin
    and E-Cadherin Positive Primary Renal Epithelial Cells.” <i>PLOS ONE</i> 7, no.
    8 (2012): e43584. <a href="https://doi.org/10.1371/journal.pone.0043584">https://doi.org/10.1371/journal.pone.0043584</a>.'
  ieee: 'C. Keller, S. Kroening, J. Zuehlke, F. Kunath, B. Krueger, and M. Goppelt-Struebe,
    “Distinct Mesenchymal Alterations in N-Cadherin and E-Cadherin Positive Primary
    Renal Epithelial Cells,” <i>PLOS ONE</i>, vol. 7, no. 8, p. e43584, 2012, doi:
    <a href="https://doi.org/10.1371/journal.pone.0043584">10.1371/journal.pone.0043584</a>.'
  mla: Keller, Christof, et al. “Distinct Mesenchymal Alterations in N-Cadherin and
    E-Cadherin Positive Primary Renal Epithelial Cells.” <i>PLOS ONE</i>, vol. 7,
    no. 8, Public Library of Science, 2012, p. e43584, doi:<a href="https://doi.org/10.1371/journal.pone.0043584">10.1371/journal.pone.0043584</a>.
  short: C. Keller, S. Kroening, J. Zuehlke, F. Kunath, B. Krueger, M. Goppelt-Struebe,
    PLOS ONE 7 (2012) e43584.
date_created: 2024-06-30T13:53:18Z
date_updated: 2024-06-30T13:53:30Z
department:
- _id: '35'
- _id: '22'
doi: 10.1371/journal.pone.0043584
intvolume: '         7'
issue: '8'
language:
- iso: eng
page: e43584
publication: PLOS ONE
publication_identifier:
  issn:
  - 1932-6203
publisher: Public Library of Science
status: public
title: Distinct Mesenchymal Alterations in N-Cadherin and E-Cadherin Positive Primary
  Renal Epithelial Cells
type: journal_article
user_id: '49428'
volume: 7
year: '2012'
...
---
_id: '39724'
alternative_title:
- 3D STRUCTURE IN HOLOGRAPHIC POLYMER-DISPERSED LIQUID CRYSTALS
author:
- first_name: Andreas
  full_name: Redler, Andreas
  last_name: Redler
- first_name: Heinz-Siegfried
  full_name: Kitzerow, Heinz-Siegfried
  id: '254'
  last_name: Kitzerow
citation:
  ama: Redler A, Kitzerow H-S. Three-dimensional structure in holographic polymer-dispersed
    liquid crystals. <i>Polymers for Advanced Technologies</i>. 2012;24(1):7-9. doi:<a
    href="https://doi.org/10.1002/pat.3040">10.1002/pat.3040</a>
  apa: Redler, A., &#38; Kitzerow, H.-S. (2012). Three-dimensional structure in holographic
    polymer-dispersed liquid crystals. <i>Polymers for Advanced Technologies</i>,
    <i>24</i>(1), 7–9. <a href="https://doi.org/10.1002/pat.3040">https://doi.org/10.1002/pat.3040</a>
  bibtex: '@article{Redler_Kitzerow_2012, title={Three-dimensional structure in holographic
    polymer-dispersed liquid crystals}, volume={24}, DOI={<a href="https://doi.org/10.1002/pat.3040">10.1002/pat.3040</a>},
    number={1}, journal={Polymers for Advanced Technologies}, publisher={Wiley}, author={Redler,
    Andreas and Kitzerow, Heinz-Siegfried}, year={2012}, pages={7–9} }'
  chicago: 'Redler, Andreas, and Heinz-Siegfried Kitzerow. “Three-Dimensional Structure
    in Holographic Polymer-Dispersed Liquid Crystals.” <i>Polymers for Advanced Technologies</i>
    24, no. 1 (2012): 7–9. <a href="https://doi.org/10.1002/pat.3040">https://doi.org/10.1002/pat.3040</a>.'
  ieee: 'A. Redler and H.-S. Kitzerow, “Three-dimensional structure in holographic
    polymer-dispersed liquid crystals,” <i>Polymers for Advanced Technologies</i>,
    vol. 24, no. 1, pp. 7–9, 2012, doi: <a href="https://doi.org/10.1002/pat.3040">10.1002/pat.3040</a>.'
  mla: Redler, Andreas, and Heinz-Siegfried Kitzerow. “Three-Dimensional Structure
    in Holographic Polymer-Dispersed Liquid Crystals.” <i>Polymers for Advanced Technologies</i>,
    vol. 24, no. 1, Wiley, 2012, pp. 7–9, doi:<a href="https://doi.org/10.1002/pat.3040">10.1002/pat.3040</a>.
  short: A. Redler, H.-S. Kitzerow, Polymers for Advanced Technologies 24 (2012) 7–9.
date_created: 2023-01-24T18:36:08Z
date_updated: 2023-01-24T18:36:33Z
department:
- _id: '313'
- _id: '230'
- _id: '638'
doi: 10.1002/pat.3040
intvolume: '        24'
issue: '1'
keyword:
- Polymers and Plastics
language:
- iso: eng
page: 7-9
publication: Polymers for Advanced Technologies
publication_identifier:
  issn:
  - 1042-7147
publication_status: published
publisher: Wiley
status: public
title: Three-dimensional structure in holographic polymer-dispersed liquid crystals
type: journal_article
user_id: '254'
volume: 24
year: '2012'
...
