@article{54939, abstract = {{Background: Renal tubular epithelial cells of proximal and distal origin differ markedly in their physiological functions. Therefore, we hypothesized that they also differ in their capacity to undergo epithelial to mesenchymal alterations. Results: We used cultures of freshly isolated primary human tubular cells. To distinguish cells of different tubular origin we took advantage of the fact that human proximal epithelial cells uniquely express N-cadherin instead of E-cadherin as major cell-cell adhesion molecule. To provoke mesenchymal alteration we treated these cocultures with TGF-$\beta$ for up to 6 days. Within this time period, the morphology of distal tubular cells was barely altered. In contrast to tubular cell lines, E-cadherin was not down-regulated by TGF-$\beta$, even though TGF-$\beta$ signal transduction was initiated as demonstrated by nuclear localization of Smad2/3. Analysis of transcription factors and miRNAs possibly involved in E-cadherin regulation revealed high levels of miRNAs of the miR200-family, which may contribute to the stability of E-cadherin expression in human distal tubular epithelial cells. By contrast, proximal tubular epithelial cells altered their phenotype when treated with TGF-$\beta$. They became elongated and formed three-dimensional structures. Rho-kinases were identified as modulators of TGF-$\beta$-induced morphological alterations. Non-specific inhibition of Rho-kinases resulted in stabilization of the epithelial phenotype, while partial effects were observed upon downregulation of Rho-kinase isoforms ROCK1 and ROCK2. The distinct reactivity of proximal and distal cells was retained when the cells were cultured as polarized cells. Conclusions: Interference with Rho-kinase signaling provides a target to counteract TGF-$\beta$-mediated mesenchymal alterations of epithelial cells, particularly in proximal tubular epithelial cells. Furthermore, primary distal tubular cells differed from cell lines by their high phenotypic stability which included constant expression of E-cadherin. Our cell culture system of primary epithelial cells is thus suitable to understand and modulate cellular remodeling processes of distinct tubular cells relevant for human renal disease.}}, author = {{Keller, Christof and Kroening, Sven and Zuehlke, Jonathan and Kunath, Frank and Krueger, Bettina and Goppelt-Struebe, Margarete}}, issn = {{1932-6203}}, journal = {{PLOS ONE}}, number = {{8}}, pages = {{e43584}}, publisher = {{Public Library of Science}}, title = {{{Distinct Mesenchymal Alterations in N-Cadherin and E-Cadherin Positive Primary Renal Epithelial Cells}}}, doi = {{10.1371/journal.pone.0043584}}, volume = {{7}}, year = {{2012}}, } @article{39724, author = {{Redler, Andreas and Kitzerow, Heinz-Siegfried}}, issn = {{1042-7147}}, journal = {{Polymers for Advanced Technologies}}, keywords = {{Polymers and Plastics}}, number = {{1}}, pages = {{7--9}}, publisher = {{Wiley}}, title = {{{Three-dimensional structure in holographic polymer-dispersed liquid crystals}}}, doi = {{10.1002/pat.3040}}, volume = {{24}}, year = {{2012}}, } @article{40231, author = {{Meier-Gräwe, Uta and Wagenknecht, Inga}}, journal = {{Frühe Kindheit}}, pages = {{24--29}}, publisher = {{Deutsche Liga für das Kind in Familie und Gesellschaft e. V.}}, title = {{{Frühe Hilfen sind eine Zukunftsinvestition}}}, volume = {{14}}, year = {{2012}}, } @article{39520, author = {{Brockmeier, A and Rodriguez, F J Santos and Harrison, M and Hilleringmann, Ulrich}}, issn = {{0960-1317}}, journal = {{Journal of Micromechanics and Microengineering}}, keywords = {{Electrical and Electronic Engineering, Mechanical Engineering, Mechanics of Materials, Electronic, Optical and Magnetic Materials}}, number = {{12}}, publisher = {{IOP Publishing}}, title = {{{Surface tension and its role for vertical wet etching of silicon}}}, doi = {{10.1088/0960-1317/22/12/125012}}, volume = {{22}}, year = {{2012}}, } @article{39522, author = {{Brockmeier, A and Rodriguez, F J Santos and Harrison, M and Hilleringmann, Ulrich}}, issn = {{0960-1317}}, journal = {{Journal of Micromechanics and Microengineering}}, keywords = {{Electrical and Electronic Engineering, Mechanical Engineering, Mechanics of Materials, Electronic, Optical and Magnetic Materials}}, number = {{12}}, publisher = {{IOP Publishing}}, title = {{{Surface tension and its role for vertical wet etching of silicon}}}, doi = {{10.1088/0960-1317/22/12/125012}}, volume = {{22}}, year = {{2012}}, } @article{52225, author = {{Schäfer, Mirko and Wagner, Johannes and Schlüter, Alexander and Hesselbach, Jens}}, issn = {{2305-9974}}, journal = {{SNE Simulation Notes Europe}}, number = {{1}}, pages = {{1--6}}, publisher = {{ARGESIM Arbeitsgemeinschaft Simulation News}}, title = {{{Energy Flows in Industrial Buildings and Machines using the Example of a Node Model}}}, doi = {{10.11128/sne.22.tn.10103}}, volume = {{22}}, year = {{2012}}, } @inproceedings{60458, abstract = {{Digital 3D models are key components in many industrial and scientific sectors. In numerous domains polygonmeshes have become a de facto standard for model representation. In practice meshes often have a number ofdefects and flaws that make them incompatible with quality requirements of specific applications. Hence, repairingsuch defects in order to achieve compatibility is a highly important task - in academic as well as industrial applications. In this tutorial we first systematically analyze typical application contexts together with their requirementsand issues, as well as the various types of defects that typically play a role. Subsequently, we considerexisting techniques to process, repair, and improve the structure, geometry, and topology of imperfect meshes,aiming at making them appropriate to case-by-case requirements. We present seminal works and key algorithms,discuss extensions and improvements, and analyze the respective advantages and disadvantages depending onthe application context. Furthermore, we outline directions where further research is particularly important orpromising.}}, author = {{Campen, Marcel and Attene, Marco and Kobbelt, Leif}}, booktitle = {{Eurographics 2012 Tutorials}}, title = {{{A Practical Guide to Polygon Mesh Repairing}}}, doi = {{10.2312/CONF/EG2012/TUTORIALS/T4}}, year = {{2012}}, } @article{52868, author = {{Grimme, Britta and Lipinski, John and Schöner, Gregor}}, journal = {{Experimental brain research}}, pages = {{185–200}}, publisher = {{Springer}}, title = {{{Naturalistic arm movements during obstacle avoidance in 3D and the identification of movement primitives}}}, volume = {{222}}, year = {{2012}}, } @inproceedings{25421, author = {{Ngonga Ngomo, Axel-Cyrille and Auer, Sören}}, booktitle = {{{IJCAI} 2011, Proceedings of the 22nd International Joint Conference on Artificial Intelligence, Barcelona, Catalonia, Spain, July 16-22, 2011}}, editor = {{Walsh, Toby}}, pages = {{2312--2317}}, publisher = {{{IJCAI/AAAI}}}, title = {{{LIMES - A Time-Efficient Approach for Large-Scale Link Discovery on the Web of Data}}}, doi = {{10.5591/978-1-57735-516-8/IJCAI11-385}}, year = {{2011}}, } @inproceedings{25427, author = {{Shekarpour, Saeedeh and Auer, Sören and Ngonga Ngomo, Axel-Cyrille and Gerber, Daniel and Hellmann, Sebastian and Stadler, Claus}}, booktitle = {{Proceedings of the 2011 {IEEE/WIC/ACM} International Conference on Web Intelligence, {WI} 2011, Campus Scientifique de la Doua, Lyon, France, August 22-27, 2011}}, editor = {{Boissier, Olivier and Benatallah, Boualem and P. Papazoglou, Mike and W. Ras, Zbigniew and Hacid, Mohand-Said}}, pages = {{203--210}}, publisher = {{{IEEE} Computer Society}}, title = {{{Keyword-Driven SPARQL Query Generation Leveraging Background Knowledge}}}, doi = {{10.1109/WI-IAT.2011.70}}, year = {{2011}}, } @inproceedings{26660, abstract = {{During rescue scenarios it is indispensable to obtain an overview of the situation. Unmanned aerial vehicles (UAVs) can gather the necessary information in a fast and efficient way. This paper presents an approach for path planning in 3D environments offering a solution to explore disaster areas including, e.g., partially or completely destroyed buildings. Using multiple UAVs decreases the time needed to receive a complete overview if the problem of coordination and task allocation is solved. We present an approach for the use of multiple UAVs. The UAVs work in a distributed manner without any central coordination instance and cover the exploration of terrains as well as goal-oriented path planning. When using multiple UAVs redundant exploration is avoided through the use of inter-UAV-communication. The approach is based on potential fields and uses the simplicity of the gradient method to calculate paths for fast exploration of the terrain. }}, author = {{Rasche, Christoph and Stern, Claudius and Kleinjohann, Lisa and Kleinjohann, Bernd}}, booktitle = {{The 5th International Conference on Automation, Robotics and Applications (ICARA 2011)}}, title = {{{A Distributed Multi-UAV Path Planning Approach for 3D Environments}}}, year = {{2011}}, } @inproceedings{26702, author = {{Thuy, Andreas}}, booktitle = {{Reconfigurable Communication-centric Systems-on-Chip (ReCoSoC), 2011 6th International Workshop on }}, publisher = {{IEEE Xplore}}, title = {{{ Comparison of periodic and aperiodic task models for cyber-physical-systems}}}, year = {{2011}}, } @article{26904, author = {{Herbst, Antje and Diethelm, Katharina and Cheng, Guo and Alexy, Ute and Icks, Andrea and Buyken, Anette}}, issn = {{0022-3166}}, journal = {{The Journal of Nutrition}}, pages = {{1348--1354}}, title = {{{Direction of Associations between Added Sugar Intake in Early Childhood and Body Mass Index at Age 7 Years May Depend on Intake Levels}}}, doi = {{10.3945/jn.110.137000}}, year = {{2011}}, } @article{26906, abstract = {{AbstractObjectiveNutrition-related health problems such as obesity are frequent among children and adolescents of Turkish descent living in Germany, yet data on their dietary habits are scarce. One reason might be the lack of validated assessment tools for this target group. We therefore aimed to validate protein and K intakes from one 24 h recall against levels estimated from one 24 h urine sample in children and adolescents of Turkish descent living in Germany.DesignCross-sectional analyses comprised estimation of mean differences, Pearson correlation coefficients, cross-classifications and Bland–Altman plots to assess the agreement between the nutritional intake estimated from a single 24 h recall and a single 24 h urine sample collected on the previous day.SettingDortmund, Germany.SubjectsData from forty-three study participants (aged 5–18 years; 26 % overweight) with a traditional Turkish background were included.ResultsThe 24 h recall significantly overestimated mean protein and K intake by 10·7 g/d (95 % CI of mean difference: 0·6, 20·7 g/d) and 344 mg/d (95 % CI 8, 680 mg/d), respectively. Correlations between intake estimates were r = 0·25 (P = 0·1) and 0·31 (P = 0·05). Both methods classified 70 % and 69 % of the participants into the same/adjacent quartile of protein and K intake and misclassified 7 % and 7 %, respectively, into the opposite quartile. Bland–Altman plots indicated a wide scattering of differences in both protein and K intake.ConclusionsAmong children and adolescents of traditional Turkish descent living in Germany, one 24 h recall may only be valid for categorizing subjects into high, medium or low consumers.}}, author = {{Bokhof, Beate and Buyken, Anette and Doğan, Canan and Karaboğa, Arzu and Kaiser, Josa and Sonntag, Antje and Kroke, Anja}}, issn = {{1368-9800}}, journal = {{Public Health Nutrition}}, pages = {{640--647}}, title = {{{Validation of protein and potassium intakes assessed from 24 h recalls against levels estimated from 24 h urine samples in children and adolescents of Turkish descent living in Germany: results from the EVET! Study}}}, doi = {{10.1017/s1368980011002734}}, year = {{2011}}, } @article{27010, author = {{Diethelm, Katharina and Remer, Thomas and Jilani, Hannah and Kunz, Clemens and Buyken, Anette}}, issn = {{0261-5614}}, journal = {{Clinical Nutrition}}, pages = {{640--646}}, title = {{{Associations between the macronutrient composition of the evening meal and average daily sleep duration in early childhood}}}, doi = {{10.1016/j.clnu.2011.05.004}}, year = {{2011}}, } @article{27011, abstract = {{There are no published data regarding the overall dietary glycaemic index (GI) and glycaemic load (GL) of Australian children and adolescents. We therefore aim to describe the dietary GI and GL of participants of the 2007 Australian National Children's Nutrition and Physical Activity Survey (2007ANCNPAS), and to identify the main foods contributing to their GL. Children, aged 2–16 years, who provided two 24 h recalls in the 2007ANCNPAS were included. A final dataset of 4184 participants was analysed. GI of each food item was assigned using a previously published method. GL was calculated, and food groups contributing to the GL were described by age group and sex. The weighted mean dietary GI and GL of the participants were 54 (sd 5) and 136 (sd 44), respectively. Among the nutrients examined, Ca had the highest inverse relationship with GI (P < 0·001), while percentage energy from starch was most positively associated with GI. The association between fibre density and GI was modest, and percentage energy from sugar had an inverse relationship with GI. Daily dietary GL contributed by energy-dense and/or nutrient-poor (EDNP) items in subjects aged 14–16 years was more than doubled that of subjects aged 2–3 years. To conclude, Australian children and adolescents were having a high-GI dietary pattern characterised by high-starchy food intake and low Ca intake. A significant proportion of their dietary GL was from EDNP foods. Efforts to reduce dietary GI and GL in children and adolescents should focus on energy-dense starchy foods.}}, author = {{Chun Yu Louie, Jimmy and Buyken, Anette and Heyer, Kristina and Flood, Victoria M.}}, issn = {{0007-1145}}, journal = {{British Journal of Nutrition}}, pages = {{1273--1282}}, title = {{{Dietary glycaemic index and glycaemic load among Australian children and adolescents}}}, doi = {{10.1017/s0007114511001577}}, year = {{2011}}, } @article{27068, abstract = {{AbstractObjectiveHighly processed foods such as convenience foods usually have a high salt content and therefore might indirectly act as adipogenic due to an increasing consumption of sugar-containing beverages (SCB). We examined the association between dietary salt and body weight status.DesignWe used data on urinary Na excretion as an indicator of dietary salt and BMI standard deviation score (BMI-SDS) and percentage body fat (%BF) of children and adolescents participating in the DONALD (Dortmund Nutritional and Anthropometric Longitudinally Designed) Study.SettingDortmund, Germany.SubjectsChildren and adolescents (n 364) who had at least two 24 h urine samples and two dietary records in the observational period between 2003 and 2009 were considered in our data analysis.ResultsRepeated-measures regression models revealed that urinary Na was positively associated with BMI-SDS (+0·202 SDS/g Na excretion at baseline; P < 0·001) and %BF (+1·303 %BF/g Na excretion at baseline; P < 0·01) at baseline in boys and girls. These associations remained significant after adjustment for SCB consumption and total energy intake. Furthermore, there was a positive trend between baseline Na excretion and the individual change in %BF in the study period (+0·364 increase in %BF/g Na excretion at baseline), which was confirmed after inclusion of SCB consumption or total energy intake. There was no significant association between the change in Na excretion and the concurrent change of either BMI-SDS or %BF in any model.ConclusionsOur results suggest that a high intake of processed salty foods could have a negative impact on body weight status in children and adolescents independently from their consumption of SCB.}}, author = {{Libuda, Lars and Kersting, Mathilde and Alexy, Ute}}, issn = {{1368-9800}}, journal = {{Public Health Nutrition}}, pages = {{433--441}}, title = {{{Consumption of dietary salt measured by urinary sodium excretion and its association with body weight status in healthy children and adolescents}}}, doi = {{10.1017/s1368980011002138}}, year = {{2011}}, } @article{27069, author = {{Alexy, Ute and Cheng, Guo and Libuda, Lars and Hilbig, Annett and Kersting, Mathilde}}, issn = {{0261-5614}}, journal = {{Clinical Nutrition}}, pages = {{78--84}}, title = {{{24h-Sodium excretion and hydration status in children and adolescents - Results of the DONALD Study}}}, doi = {{10.1016/j.clnu.2011.08.014}}, year = {{2011}}, } @article{27076, author = {{Muckelbauer, R. and Libuda, Lars and Clausen, K. and Kersting, M.}}, issn = {{1436-9990}}, journal = {{Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz}}, pages = {{339--348}}, title = {{{Ansätze der Übergewichtsprävention durch verbessertes Trinkverhalten im Setting Grundschule}}}, doi = {{10.1007/s00103-010-1224-7}}, year = {{2011}}, } @inbook{27589, author = {{Muckelbauer, R. and Libuda, Lars and Kersting, M.}}, booktitle = {{Developing Children´s Food Products.}}, isbn = {{978-1-84569-431-9 }}, publisher = {{Woodhead Publishing Limited }}, title = {{{Fluids and children’s health. }}}, year = {{2011}}, }