[{"publication":"European Journal of Nutrition","citation":{"chicago":"Perrar, Ines, Anette Buyken, Katharina J. Penczynski, Thomas Remer, Gunter G. Kuhnle, Christian Herder, Michael Roden, Karen Della Corte, Ute Nöthlings, and Ute Alexy. “Relevance of Fructose Intake in Adolescence for Fatty Liver Indices in Young Adulthood.” European Journal of Nutrition, 2021, 3029–41. https://doi.org/10.1007/s00394-020-02463-2.","short":"I. Perrar, A. Buyken, K.J. Penczynski, T. Remer, G.G. Kuhnle, C. Herder, M. Roden, K. Della Corte, U. Nöthlings, U. Alexy, European Journal of Nutrition (2021) 3029–3041.","apa":"Perrar, I., Buyken, A., Penczynski, K. J., Remer, T., Kuhnle, G. G., Herder, C., Roden, M., Della Corte, K., Nöthlings, U., & Alexy, U. (2021). Relevance of fructose intake in adolescence for fatty liver indices in young adulthood. European Journal of Nutrition, 3029–3041. https://doi.org/10.1007/s00394-020-02463-2","ieee":"I. Perrar et al., “Relevance of fructose intake in adolescence for fatty liver indices in young adulthood,” European Journal of Nutrition, pp. 3029–3041, 2021, doi: 10.1007/s00394-020-02463-2.","ama":"Perrar I, Buyken A, Penczynski KJ, et al. Relevance of fructose intake in adolescence for fatty liver indices in young adulthood. European Journal of Nutrition. Published online 2021:3029-3041. doi:10.1007/s00394-020-02463-2","bibtex":"@article{Perrar_Buyken_Penczynski_Remer_Kuhnle_Herder_Roden_Della Corte_Nöthlings_Alexy_2021, title={Relevance of fructose intake in adolescence for fatty liver indices in young adulthood}, DOI={10.1007/s00394-020-02463-2}, journal={European Journal of Nutrition}, author={Perrar, Ines and Buyken, Anette and Penczynski, Katharina J. and Remer, Thomas and Kuhnle, Gunter G. and Herder, Christian and Roden, Michael and Della Corte, Karen and Nöthlings, Ute and Alexy, Ute}, year={2021}, pages={3029–3041} }","mla":"Perrar, Ines, et al. “Relevance of Fructose Intake in Adolescence for Fatty Liver Indices in Young Adulthood.” European Journal of Nutrition, 2021, pp. 3029–41, doi:10.1007/s00394-020-02463-2."},"abstract":[{"text":"Abstract\r\n Purpose\r\n To examine the association between fructose intake in adolescence and fatty liver indices (hepatic steatosis index (HSI), fatty liver index (FLI)) in young adulthood.\r\n \r\n Methods\r\n Overall, 246 participants of the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study who had a fasting blood sample in adulthood (18–36 years), at least two 3-day weighed dietary records for calculating fructose intakes and other fructose-containing sugars (total (TS), free (FS), added sugar (AS)) as well as two complete 24-h urine samples for calculating sugar excretion (fructose excretion (FE), fructose + sucrose excretion (FE + SE)) in adolescence (males: 9.5–16.5 years; females: 8.5–15.5 years) were analysed using multivariable linear regression analyses.\r\n \r\n Results\r\n On the level of dietary intake, no prospective associations were observed between adolescent fructose intake and both adult fatty liver indices, whereas higher FS intakes were associated with lower levels of HSI (Ptrend = 0.02) and FLI (Ptrend = 0.03). On the urinary excretion level, however, a higher FE (Ptrend = 0.03) and FE + SE (Ptrend = 0.01) in adolescence were prospectively related to higher adult FLI values. No associations were observed between adolescent sugar excretion and adult HSI.\r\n \r\n Conclusion\r\n The present study does not provide unambiguous support for a detrimental impact of adolescent fructose intake on adult liver health. Nonetheless, further examinations estimating exposure by means of urinary excretion as well as dietary intake levels appear warranted.\r\n ","lang":"eng"}],"date_created":"2021-10-29T13:48:27Z","type":"journal_article","department":[{"_id":"17"},{"_id":"22"},{"_id":"571"}],"status":"public","year":"2021","title":"Relevance of fructose intake in adolescence for fatty liver indices in young adulthood","author":[{"last_name":"Perrar","first_name":"Ines","full_name":"Perrar, Ines"},{"last_name":"Buyken","first_name":"Anette","full_name":"Buyken, Anette","id":"65985"},{"full_name":"Penczynski, Katharina J.","first_name":"Katharina J.","last_name":"Penczynski"},{"last_name":"Remer","first_name":"Thomas","full_name":"Remer, Thomas"},{"first_name":"Gunter G.","last_name":"Kuhnle","full_name":"Kuhnle, Gunter G."},{"full_name":"Herder, Christian","last_name":"Herder","first_name":"Christian"},{"first_name":"Michael","last_name":"Roden","full_name":"Roden, Michael"},{"first_name":"Karen","last_name":"Della Corte","full_name":"Della Corte, Karen"},{"full_name":"Nöthlings, Ute","last_name":"Nöthlings","first_name":"Ute"},{"last_name":"Alexy","first_name":"Ute","full_name":"Alexy, Ute"}],"publication_identifier":{"issn":["1436-6207","1436-6215"]},"publication_status":"published","date_updated":"2022-01-06T06:57:32Z","page":"3029-3041","_id":"27007","language":[{"iso":"eng"}],"user_id":"61597","doi":"10.1007/s00394-020-02463-2"},{"publication":"Frontiers in Nutrition","citation":{"bibtex":"@article{Della Corte_Penczynski_Kuhnle_Perrar_Herder_Roden_Wudy_Remer_Alexy_Buyken_2021, title={The Prospective Association of Dietary Sugar Intake in Adolescence With Risk Markers of Type 2 Diabetes in Young Adulthood}, DOI={10.3389/fnut.2020.615684}, journal={Frontiers in Nutrition}, author={Della Corte, Karen A. and Penczynski, Katharina and Kuhnle, Gunter and Perrar, Ines and Herder, Christian and Roden, Michael and Wudy, Stefan A. and Remer, Thomas and Alexy, Ute and Buyken, Anette}, year={2021} }","ama":"Della Corte KA, Penczynski K, Kuhnle G, et al. The Prospective Association of Dietary Sugar Intake in Adolescence With Risk Markers of Type 2 Diabetes in Young Adulthood. Frontiers in Nutrition. Published online 2021. doi:10.3389/fnut.2020.615684","mla":"Della Corte, Karen A., et al. “The Prospective Association of Dietary Sugar Intake in Adolescence With Risk Markers of Type 2 Diabetes in Young Adulthood.” Frontiers in Nutrition, 2021, doi:10.3389/fnut.2020.615684.","short":"K.A. Della Corte, K. Penczynski, G. Kuhnle, I. Perrar, C. Herder, M. Roden, S.A. Wudy, T. Remer, U. Alexy, A. Buyken, Frontiers in Nutrition (2021).","chicago":"Della Corte, Karen A., Katharina Penczynski, Gunter Kuhnle, Ines Perrar, Christian Herder, Michael Roden, Stefan A. Wudy, Thomas Remer, Ute Alexy, and Anette Buyken. “The Prospective Association of Dietary Sugar Intake in Adolescence With Risk Markers of Type 2 Diabetes in Young Adulthood.” Frontiers in Nutrition, 2021. https://doi.org/10.3389/fnut.2020.615684.","ieee":"K. A. Della Corte et al., “The Prospective Association of Dietary Sugar Intake in Adolescence With Risk Markers of Type 2 Diabetes in Young Adulthood,” Frontiers in Nutrition, 2021, doi: 10.3389/fnut.2020.615684.","apa":"Della Corte, K. A., Penczynski, K., Kuhnle, G., Perrar, I., Herder, C., Roden, M., Wudy, S. A., Remer, T., Alexy, U., & Buyken, A. (2021). The Prospective Association of Dietary Sugar Intake in Adolescence With Risk Markers of Type 2 Diabetes in Young Adulthood. Frontiers in Nutrition. https://doi.org/10.3389/fnut.2020.615684"},"abstract":[{"lang":"eng","text":"Purpose: To examine the prospective relevance of dietary sugar intake (based on dietary data as well as urinary excretion data) in adolescent years for insulin sensitivity and biomarkers of inflammation in young adulthood.Methods: Overall 254 participants of the DONALD study who had at least two 3-day weighed dietary records for calculating intakes of fructose, glucose, sucrose, total, free, added sugars, total sugars from sugar-sweetened beverages (SSB), juice, and sweets/sugar or at least two complete 24 h urine samples (n = 221) for calculating sugar excretion (urinary fructose and urinary fructose + sucrose) in adolescence (females: 9–15 years, males: 10–16 years) and a fasting blood sample in adulthood (18–36 years), were included in multivariable linear regression analyses assessing their prospective associations with adult homeostasis model assessment insulin sensitivity (HOMA2-%S) and a pro-inflammatory score (based on CRP, IL-6, IL-18, leptin, chemerin, adiponectin).Results: On the dietary intake level, no prospective associations were observed between adolescent fructose, sucrose, glucose, added, free, total sugar, or total sugar from SSB, juice or sweets/sugar intake and adult HOMA2-%S (p > 0.01). On the urinary level, however, higher excreted fructose levels were associated with improved adult HOMA2-%S (p = 0.008) among females only. No associations were observed between dietary or urinary sugars and the adult pro-inflammatory score (p > 0.01).Conclusion: The present study did not provide support that dietary sugar consumed in adolescence is associated with adult insulin sensitivity. The one potential exception was the moderate dietary consumption of fructose, which showed a beneficial association with adult fasting insulin and insulin sensitivity."}],"date_created":"2021-10-29T13:59:00Z","type":"journal_article","department":[{"_id":"17"},{"_id":"22"},{"_id":"571"},{"_id":"35"}],"status":"public","title":"The Prospective Association of Dietary Sugar Intake in Adolescence With Risk Markers of Type 2 Diabetes in Young Adulthood","year":"2021","publication_identifier":{"issn":["2296-861X"]},"author":[{"full_name":"Della Corte, Karen A.","last_name":"Della Corte","first_name":"Karen A."},{"full_name":"Penczynski, Katharina","first_name":"Katharina","last_name":"Penczynski"},{"first_name":"Gunter","last_name":"Kuhnle","full_name":"Kuhnle, Gunter"},{"last_name":"Perrar","first_name":"Ines","full_name":"Perrar, Ines"},{"last_name":"Herder","first_name":"Christian","full_name":"Herder, Christian"},{"last_name":"Roden","first_name":"Michael","full_name":"Roden, Michael"},{"full_name":"Wudy, Stefan A.","last_name":"Wudy","first_name":"Stefan A."},{"last_name":"Remer","first_name":"Thomas","full_name":"Remer, Thomas"},{"full_name":"Alexy, Ute","first_name":"Ute","last_name":"Alexy"},{"id":"65985","full_name":"Buyken, Anette","last_name":"Buyken","first_name":"Anette"}],"date_updated":"2022-01-06T06:57:32Z","publication_status":"published","language":[{"iso":"eng"}],"_id":"27014","doi":"10.3389/fnut.2020.615684","user_id":"61597"},{"date_updated":"2022-01-06T06:57:35Z","publication_status":"published","publication_identifier":{"issn":["0954-3007","1476-5640"]},"author":[{"last_name":"Jankovic","first_name":"Nicole","full_name":"Jankovic, Nicole"},{"full_name":"Schmitting, Sarah","first_name":"Sarah","last_name":"Schmitting"},{"first_name":"Bettina","last_name":"Krüger","orcid":"0000-0001-5351-1785","full_name":"Krüger, Bettina","id":"49428"},{"first_name":"Ute","last_name":"Nöthlings","full_name":"Nöthlings, Ute"},{"full_name":"Buyken, Anette E.","first_name":"Anette E.","last_name":"Buyken","id":"65985"},{"full_name":"Alexy, Ute","last_name":"Alexy","first_name":"Ute"}],"status":"public","year":"2021","title":"Changes in chronotype and social jetlag during adolescence and their association with concurrent changes in BMI-SDS and body composition, in the DONALD Study","doi":"10.1038/s41430-021-01024-y","user_id":"49428","_id":"27114","language":[{"iso":"eng"}],"abstract":[{"text":"Abstract\r\n Background/objectives\r\n Adolescence is a critical period for both the development of overweight and the transition toward a later chronotype, often accompanied by an increase in social jetlag. This study assessed whether changes in chronotype and social jetlag, are linked to changes in body composition during adolescence.\r\n \r\n Subjects/methods\r\n We used data from the DONALD open cohort study, collected between 2014 and 2019, from 213 adolescents (9–17 years at baseline, 45% females) having at least two measures of chronotype and anthropometry (N = 572). Chronotype was assessed with the Munich Chronotype Questionnaire and defined as: midpoint of sleep corrected for sleep-debt (MSFsc) accumulated over the week (later MSFsc represents later chronotype). Social jetlag (SJL) defines the difference between midpoint of sleep during week and weekend. Calculations for Fat Free Mass Index (FFMI [kg/m2)]) and Fat Mass Index (FMI) [kg/m2)]) were based on body fat percentage, weight, and height. To analyze the associations, we used linear mixed-effect regression models. Finally, the total cohort was split into three biologically relevant age groups (cut-off set at <12 years, ≥12 to ≤15 years and >15 years).\r\n \r\n Results\r\n Median follow-up was 2.1 years. Overall, change toward a later chronotype was significantly related with an increase in FMI (ß: 0.05, 95% CI: 0.01–0.08). A 1 h increase in social jetlag predicted an increase in BMI-SDS of 0.08 SDS units (95% CI: 0.01–0.14) and in FMI of 0.04 kg/m2 (95% CI: 0.003–0.08). Associations were stronger for the age group ≥12 to ≤15 years (p for interaction: <0.001). No relationship was found with FFMI.\r\n \r\n Conclusions\r\n Changes in MSFsc and SJL during adolescence were associated with concurrent changes in BMI-SDS and FMI. The age ≥12 to ≤15 years appears to be a sensitive period in which chronobiological changes were clearly associated with increasing body fatness.\r\n ","lang":"eng"}],"citation":{"short":"N. Jankovic, S. Schmitting, B. Krüger, U. Nöthlings, A.E. Buyken, U. Alexy, European Journal of Clinical Nutrition (2021).","chicago":"Jankovic, Nicole, Sarah Schmitting, Bettina Krüger, Ute Nöthlings, Anette E. Buyken, and Ute Alexy. “Changes in Chronotype and Social Jetlag during Adolescence and Their Association with Concurrent Changes in BMI-SDS and Body Composition, in the DONALD Study.” European Journal of Clinical Nutrition, 2021. https://doi.org/10.1038/s41430-021-01024-y.","apa":"Jankovic, N., Schmitting, S., Krüger, B., Nöthlings, U., Buyken, A. E., & Alexy, U. (2021). Changes in chronotype and social jetlag during adolescence and their association with concurrent changes in BMI-SDS and body composition, in the DONALD Study. European Journal of Clinical Nutrition. https://doi.org/10.1038/s41430-021-01024-y","ieee":"N. Jankovic, S. Schmitting, B. Krüger, U. Nöthlings, A. E. Buyken, and U. Alexy, “Changes in chronotype and social jetlag during adolescence and their association with concurrent changes in BMI-SDS and body composition, in the DONALD Study,” European Journal of Clinical Nutrition, 2021, doi: 10.1038/s41430-021-01024-y.","ama":"Jankovic N, Schmitting S, Krüger B, Nöthlings U, Buyken AE, Alexy U. Changes in chronotype and social jetlag during adolescence and their association with concurrent changes in BMI-SDS and body composition, in the DONALD Study. European Journal of Clinical Nutrition. Published online 2021. doi:10.1038/s41430-021-01024-y","bibtex":"@article{Jankovic_Schmitting_Krüger_Nöthlings_Buyken_Alexy_2021, title={Changes in chronotype and social jetlag during adolescence and their association with concurrent changes in BMI-SDS and body composition, in the DONALD Study}, DOI={10.1038/s41430-021-01024-y}, journal={European Journal of Clinical Nutrition}, author={Jankovic, Nicole and Schmitting, Sarah and Krüger, Bettina and Nöthlings, Ute and Buyken, Anette E. and Alexy, Ute}, year={2021} }","mla":"Jankovic, Nicole, et al. “Changes in Chronotype and Social Jetlag during Adolescence and Their Association with Concurrent Changes in BMI-SDS and Body Composition, in the DONALD Study.” European Journal of Clinical Nutrition, 2021, doi:10.1038/s41430-021-01024-y."},"publication":"European Journal of Clinical Nutrition","department":[{"_id":"35"},{"_id":"22"},{"_id":"571"}],"type":"journal_article","date_created":"2021-11-03T12:57:29Z"},{"publication_identifier":{"issn":["1422-4917","1664-2880"]},"author":[{"first_name":"Raphael","last_name":"Hirtz","full_name":"Hirtz, Raphael"},{"full_name":"Zheng, Yiran","last_name":"Zheng","first_name":"Yiran"},{"full_name":"Rajcsanyi, Luisa S.","last_name":"Rajcsanyi","first_name":"Luisa S."},{"full_name":"Libuda, Lars","first_name":"Lars","orcid":"0000-0003-1603-3133","last_name":"Libuda","id":"88682"},{"first_name":"Jochen","last_name":"Antel","full_name":"Antel, Jochen"},{"last_name":"Peters","first_name":"Triinu","full_name":"Peters, Triinu"},{"first_name":"Johannes","last_name":"Hebebrand","full_name":"Hebebrand, Johannes"},{"full_name":"Hinney, Anke","first_name":"Anke","last_name":"Hinney"}],"status":"public","title":"Ebenen der genetischen Analyse komplexer Phänotypen am Beispiel der Anorexia nervosa und der Varianz des Körpergewichts","year":"2021","date_updated":"2022-01-06T06:57:42Z","publication_status":"published","language":[{"iso":"ger"}],"_id":"27572","doi":"10.1024/1422-4917/a000829","user_id":"49428","citation":{"short":"R. Hirtz, Y. Zheng, L.S. Rajcsanyi, L. Libuda, J. Antel, T. Peters, J. Hebebrand, A. Hinney, Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie (2021).","chicago":"Hirtz, Raphael, Yiran Zheng, Luisa S. Rajcsanyi, Lars Libuda, Jochen Antel, Triinu Peters, Johannes Hebebrand, and Anke Hinney. “Ebenen der genetischen Analyse komplexer Phänotypen am Beispiel der Anorexia nervosa und der Varianz des Körpergewichts.” Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, 2021. https://doi.org/10.1024/1422-4917/a000829.","apa":"Hirtz, R., Zheng, Y., Rajcsanyi, L. S., Libuda, L., Antel, J., Peters, T., Hebebrand, J., & Hinney, A. (2021). Ebenen der genetischen Analyse komplexer Phänotypen am Beispiel der Anorexia nervosa und der Varianz des Körpergewichts. Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie. https://doi.org/10.1024/1422-4917/a000829","ieee":"R. Hirtz et al., “Ebenen der genetischen Analyse komplexer Phänotypen am Beispiel der Anorexia nervosa und der Varianz des Körpergewichts,” Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, 2021, doi: 10.1024/1422-4917/a000829.","ama":"Hirtz R, Zheng Y, Rajcsanyi LS, et al. Ebenen der genetischen Analyse komplexer Phänotypen am Beispiel der Anorexia nervosa und der Varianz des Körpergewichts. Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie. Published online 2021. doi:10.1024/1422-4917/a000829","bibtex":"@article{Hirtz_Zheng_Rajcsanyi_Libuda_Antel_Peters_Hebebrand_Hinney_2021, title={Ebenen der genetischen Analyse komplexer Phänotypen am Beispiel der Anorexia nervosa und der Varianz des Körpergewichts}, DOI={10.1024/1422-4917/a000829}, journal={Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie}, author={Hirtz, Raphael and Zheng, Yiran and Rajcsanyi, Luisa S. and Libuda, Lars and Antel, Jochen and Peters, Triinu and Hebebrand, Johannes and Hinney, Anke}, year={2021} }","mla":"Hirtz, Raphael, et al. “Ebenen der genetischen Analyse komplexer Phänotypen am Beispiel der Anorexia nervosa und der Varianz des Körpergewichts.” Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, 2021, doi:10.1024/1422-4917/a000829."},"publication":"Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie","abstract":[{"text":" Zusammenfassung. Genetische Varianten beeinflussen die Gewichtsregulation und die Entwicklung von Essstörungen. Zunächst haben familienbasierte, sogenannte formalgenetische Studien den erblichen Anteil an der Gewichtsregulation und an der Ätiologie von Essstörungen beleuchtet. In einer Vielzahl von Studien zeigten sich sowohl für die Varianz des Körpergewichts als auch für die Entstehung von Essstörungen Erblichkeitsschätzer (Heritabilitätsraten) von über 50 %. Mit diesem Wissen begab man sich in den 90er-Jahren des letzten Jahrhunderts auf die Suche nach den zugrundeliegenden Genen (genauer: genetischen Varianten), die das Körpergewicht, das Essverhalten oder beide Phänotypen auf Grundlage geteilter Mechanismen beeinflussen. Zunächst wurden Kandidatengenstudien durchgeführt. Dabei untersuchte man auf Grundlage unterschiedlicher, v. a. aber pathophysiologisch plausibler Überlegungen Gene mit hoher Relevanz für die untersuchten Phänotypen. Dieser Ansatz war für Essstörungen nicht sehr erfolgreich, für die Gewichtsregulation konnte eine Handvoll Gene identifiziert werden. Verbunden mit großen methodischen Fortschritten in der genetischen Forschung und v. a. der Etablierung sogenannter genomweiter Assoziationsstudien (GWAS) Anfang der 2000er-Jahre konnten bislang über 1000 Varianten/Genorte detektiert werden, die das Körpergewicht beeinflussen. Für die Essstörung Anorexia nervosa (AN) sind aktuell acht solcher Genorte beschrieben. Diese Ergebnisse, aber auch aktuelle Ansätze zu phänotypübergreifenden Analysen lassen Einblicke in die komplexe Regulation des Körpergewichtes zu und haben zudem unerwartete Pathomechanismen für AN aufgezeigt. ","lang":"eng"}],"date_created":"2021-11-18T19:30:20Z","department":[{"_id":"35"},{"_id":"22"},{"_id":"395"}],"type":"journal_article"},{"abstract":[{"lang":"eng","text":" Zusammenfassung. Einleitung: Klassische ernährungsepidemiologische Studien (Beobachtungsstudien und randomisierte Interventionsstudien) zeigen, dass die Ernährung ein wichtiger Ansatzpunkt für die Prävention und Therapie psychischer Störungen sein könnte. Diese Studientypen haben allerdings Limitationen, die bei der Ergebnisinterpretation berücksichtigt werden müssen. In dieser narrativen übersichtsarbeit wird beschrieben, wie genetische Studien ein Bindeglied darstellen können, um einen Zusammenhang zwischen Ernährung und psychischen Störungen herzustellen. Methodik: Im Artikel werden verschiedene Ansätze genetischer phänotypübergreifender Analysen sowie Beispiele für deren Anwendungen in der ernährungspsychiatrischen Forschung beschrieben. Darüber hinaus werden spezifische Voraussetzungen sowie Stärken und Schwächen diskutiert. Ergebnisse: Als Methoden genetischer phänotypübergreifender Analysen sind im Rahmen ernährungspsychiatrischer Forschung bislang genetische Korrelationsanalysen, Look-up-Analysen sowie Mendelsche Randomisierungsstudien (MR-Studien) eingesetzt worden. Genetische Korrelationsanalysen und Look-up-Analysen geben erste Hinweise auf mögliche genetische überlappungen zwischen einer psychischen Störung und einem Stoffwechselweg und/oder der Versorgung mit einem spezifischen Nährstoff. MR-Studien sind weitergehende Detailanalysen mit dem Ziel, Kausalzusammenhänge zu identifizieren, beinhalten allerdings sehr spezifische Grundvoraussetzungen für ihre Durchführung. Schlussfolgerung: Genetische phänotypübergreifende Analysen sind eine sinnvolle Ergänzung der klassischen Ernährungsepidemiologie. Insbesondere signifikante Ergebnisse von MR-Studien sind eine wichtige Grundlage zur Entwicklung geeigneter Ernährungsinterventionen, die in nachfolgenden randomisiert kontrollierten Interventionsstudien mit deutlich erhöhter Erfolgsaussicht getestet werden können. Sie sind somit wichtige Instrumente einer effizienten ernährungspsychiatrischen Forschung. "}],"publication":"Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie","citation":{"mla":"Libuda, Lars, et al. “Ernährungseffekten auf der Spur – Wie die Genetik helfen kann, Zusammenhänge zwischen Ernährung und seelischer Gesundheit aufzudecken.” Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, 2021, pp. 1–10, doi:10.1024/1422-4917/a000807.","ama":"Libuda L, Hebebrand J, Föcker M, Peters T, Hinney A. Ernährungseffekten auf der Spur – Wie die Genetik helfen kann, Zusammenhänge zwischen Ernährung und seelischer Gesundheit aufzudecken. Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie. Published online 2021:1-10. doi:10.1024/1422-4917/a000807","bibtex":"@article{Libuda_Hebebrand_Föcker_Peters_Hinney_2021, title={Ernährungseffekten auf der Spur – Wie die Genetik helfen kann, Zusammenhänge zwischen Ernährung und seelischer Gesundheit aufzudecken}, DOI={10.1024/1422-4917/a000807}, journal={Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie}, author={Libuda, Lars and Hebebrand, Johannes and Föcker, Manuel and Peters, Triinu and Hinney, Anke}, year={2021}, pages={1–10} }","apa":"Libuda, L., Hebebrand, J., Föcker, M., Peters, T., & Hinney, A. (2021). Ernährungseffekten auf der Spur – Wie die Genetik helfen kann, Zusammenhänge zwischen Ernährung und seelischer Gesundheit aufzudecken. Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, 1–10. https://doi.org/10.1024/1422-4917/a000807","ieee":"L. Libuda, J. Hebebrand, M. Föcker, T. Peters, and A. Hinney, “Ernährungseffekten auf der Spur – Wie die Genetik helfen kann, Zusammenhänge zwischen Ernährung und seelischer Gesundheit aufzudecken,” Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, pp. 1–10, 2021, doi: 10.1024/1422-4917/a000807.","chicago":"Libuda, Lars, Johannes Hebebrand, Manuel Föcker, Triinu Peters, and Anke Hinney. “Ernährungseffekten auf der Spur – Wie die Genetik helfen kann, Zusammenhänge zwischen Ernährung und seelischer Gesundheit aufzudecken.” Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, 2021, 1–10. https://doi.org/10.1024/1422-4917/a000807.","short":"L. Libuda, J. Hebebrand, M. Föcker, T. Peters, A. Hinney, Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie (2021) 1–10."},"type":"journal_article","department":[{"_id":"35"},{"_id":"22"},{"_id":"395"}],"date_created":"2021-11-18T19:33:20Z","date_updated":"2022-01-06T06:57:42Z","publication_status":"published","title":"Ernährungseffekten auf der Spur – Wie die Genetik helfen kann, Zusammenhänge zwischen Ernährung und seelischer Gesundheit aufzudecken","year":"2021","status":"public","author":[{"id":"88682","full_name":"Libuda, Lars","orcid":"0000-0003-1603-3133","last_name":"Libuda","first_name":"Lars"},{"last_name":"Hebebrand","first_name":"Johannes","full_name":"Hebebrand, Johannes"},{"full_name":"Föcker, Manuel","first_name":"Manuel","last_name":"Föcker"},{"full_name":"Peters, Triinu","last_name":"Peters","first_name":"Triinu"},{"last_name":"Hinney","first_name":"Anke","full_name":"Hinney, Anke"}],"publication_identifier":{"issn":["1422-4917","1664-2880"]},"doi":"10.1024/1422-4917/a000807","user_id":"49428","page":"1-10","_id":"27573","language":[{"iso":"ger"}]},{"_id":"27574","language":[{"iso":"eng"}],"user_id":"49428","doi":"10.3389/fendo.2021.662243","publication_identifier":{"issn":["1664-2392"]},"author":[{"full_name":"Hirtz, Raphael","first_name":"Raphael","last_name":"Hirtz"},{"id":"88682","orcid":"0000-0003-1603-3133","last_name":"Libuda","first_name":"Lars","full_name":"Libuda, Lars"},{"first_name":"Anke","last_name":"Hinney","full_name":"Hinney, Anke"},{"full_name":"Föcker, Manuel","last_name":"Föcker","first_name":"Manuel"},{"full_name":"Bühlmeier, Judith","first_name":"Judith","last_name":"Bühlmeier"},{"full_name":"Antel, Jochen","last_name":"Antel","first_name":"Jochen"},{"full_name":"Holterhus, Paul-Martin","first_name":"Paul-Martin","last_name":"Holterhus"},{"first_name":"Alexandra","last_name":"Kulle","full_name":"Kulle, Alexandra"},{"first_name":"Cordula","last_name":"Kiewert","full_name":"Kiewert, Cordula"},{"full_name":"Hebebrand, Johannes","last_name":"Hebebrand","first_name":"Johannes"},{"last_name":"Grasemann","first_name":"Corinna","full_name":"Grasemann, Corinna"}],"title":"Lack of Evidence for a Relationship Between the Hypothalamus-Pituitary-Adrenal and the Hypothalamus-Pituitary-Thyroid Axis in Adolescent Depression","year":"2021","status":"public","publication_status":"published","date_updated":"2022-01-06T06:57:42Z","date_created":"2021-11-18T19:35:06Z","department":[{"_id":"35"},{"_id":"22"},{"_id":"395"}],"type":"journal_article","citation":{"ama":"Hirtz R, Libuda L, Hinney A, et al. Lack of Evidence for a Relationship Between the Hypothalamus-Pituitary-Adrenal and the Hypothalamus-Pituitary-Thyroid Axis in Adolescent Depression. Frontiers in Endocrinology. Published online 2021. doi:10.3389/fendo.2021.662243","bibtex":"@article{Hirtz_Libuda_Hinney_Föcker_Bühlmeier_Antel_Holterhus_Kulle_Kiewert_Hebebrand_et al._2021, title={Lack of Evidence for a Relationship Between the Hypothalamus-Pituitary-Adrenal and the Hypothalamus-Pituitary-Thyroid Axis in Adolescent Depression}, DOI={10.3389/fendo.2021.662243}, journal={Frontiers in Endocrinology}, author={Hirtz, Raphael and Libuda, Lars and Hinney, Anke and Föcker, Manuel and Bühlmeier, Judith and Antel, Jochen and Holterhus, Paul-Martin and Kulle, Alexandra and Kiewert, Cordula and Hebebrand, Johannes and et al.}, year={2021} }","mla":"Hirtz, Raphael, et al. “Lack of Evidence for a Relationship Between the Hypothalamus-Pituitary-Adrenal and the Hypothalamus-Pituitary-Thyroid Axis in Adolescent Depression.” Frontiers in Endocrinology, 2021, doi:10.3389/fendo.2021.662243.","chicago":"Hirtz, Raphael, Lars Libuda, Anke Hinney, Manuel Föcker, Judith Bühlmeier, Jochen Antel, Paul-Martin Holterhus, et al. “Lack of Evidence for a Relationship Between the Hypothalamus-Pituitary-Adrenal and the Hypothalamus-Pituitary-Thyroid Axis in Adolescent Depression.” Frontiers in Endocrinology, 2021. https://doi.org/10.3389/fendo.2021.662243.","short":"R. Hirtz, L. Libuda, A. Hinney, M. Föcker, J. Bühlmeier, J. Antel, P.-M. Holterhus, A. Kulle, C. Kiewert, J. Hebebrand, C. Grasemann, Frontiers in Endocrinology (2021).","apa":"Hirtz, R., Libuda, L., Hinney, A., Föcker, M., Bühlmeier, J., Antel, J., Holterhus, P.-M., Kulle, A., Kiewert, C., Hebebrand, J., & Grasemann, C. (2021). Lack of Evidence for a Relationship Between the Hypothalamus-Pituitary-Adrenal and the Hypothalamus-Pituitary-Thyroid Axis in Adolescent Depression. Frontiers in Endocrinology. https://doi.org/10.3389/fendo.2021.662243","ieee":"R. Hirtz et al., “Lack of Evidence for a Relationship Between the Hypothalamus-Pituitary-Adrenal and the Hypothalamus-Pituitary-Thyroid Axis in Adolescent Depression,” Frontiers in Endocrinology, 2021, doi: 10.3389/fendo.2021.662243."},"publication":"Frontiers in Endocrinology","abstract":[{"text":"In adults with major depressive disorder (MDD), a dysfunction between the hypothalamus-pituitary-adrenal (HPA) and the hypothalamus-pituitary-thyroid (HPT) axis has been shown, but the interaction of both axes has not yet been studied in adolescent major depressive disorder (MDD). Data from 273 adolescents diagnosed with MDD from two single center cross-sectional studies were used for analysis. Serum levels of thyrotropin (TSH), free levothyroxine (fT4), and cortisol were determined as indicators of basal HPT and HPA axis functioning and compared to that of adolescent controls by t-tests. Quantile regression was employed in the sample of adolescents with MDD to investigate the relationship between both axes in the normal as well as the pathological range of cortisol levels, considering confounders of both axes. In adolescent MDD, cortisol levels and TSH levels were significantly elevated in comparison to controls (p = <.001, d = 1.35, large effect size, and p = <.001, d = 0.79, moderate effect size, respectively). There was a positive linear relationship between TSH and cortisol (p = .003, d = 0.25, small effect size) at the median of cortisol levels (50th percentile). However, no relationship between TSH and cortisol was found in hypercortisolemia (cortisol levels at the 97.5th percentile). These findings imply that HPT and HPA axis dysfunction is common in adolescents with MDD and that function of both axes is only loosely related. Moreover, the regulation of the HPA and HPT axis are likely subjected to age-related maturational adjustments since findings of this study differ from those reported in adults.","lang":"eng"}]},{"_id":"27746","language":[{"iso":"eng"}],"page":"2791-2799","doi":"10.1016/j.clnu.2021.03.041","user_id":"61597","publication_identifier":{"issn":["0261-5614"]},"author":[{"last_name":"Zhang","first_name":"Xiao","full_name":"Zhang, Xiao"},{"last_name":"Gong","first_name":"Yunhui","full_name":"Gong, Yunhui"},{"full_name":"Della Corte, Karen","first_name":"Karen","last_name":"Della Corte"},{"first_name":"Dianke","last_name":"Yu","full_name":"Yu, Dianke"},{"full_name":"Xue, Hongmei","last_name":"Xue","first_name":"Hongmei"},{"full_name":"Shan, Shufang","first_name":"Shufang","last_name":"Shan"},{"first_name":"Guo","last_name":"Tian","full_name":"Tian, Guo"},{"first_name":"Yi","last_name":"Liang","full_name":"Liang, Yi"},{"first_name":"Jieyi","last_name":"Zhang","full_name":"Zhang, Jieyi"},{"full_name":"He, Fang","last_name":"He","first_name":"Fang"},{"last_name":"Yang","first_name":"Dagang","full_name":"Yang, Dagang"},{"full_name":"Zhou, Rong","last_name":"Zhou","first_name":"Rong"},{"full_name":"Bao, Wei","last_name":"Bao","first_name":"Wei"},{"id":"65985","last_name":"Buyken","first_name":"Anette","full_name":"Buyken, Anette"},{"last_name":"Cheng","first_name":"Guo","full_name":"Cheng, Guo"}],"title":"Relevance of dietary glycemic index, glycemic load and fiber intake before and during pregnancy for the risk of gestational diabetes mellitus and maternal glucose homeostasis","year":"2021","status":"public","date_updated":"2022-01-06T06:57:44Z","publication_status":"published","date_created":"2021-11-23T16:19:11Z","department":[{"_id":"17"},{"_id":"22"},{"_id":"571"}],"type":"journal_article","citation":{"apa":"Zhang, X., Gong, Y., Della Corte, K., Yu, D., Xue, H., Shan, S., Tian, G., Liang, Y., Zhang, J., He, F., Yang, D., Zhou, R., Bao, W., Buyken, A., & Cheng, G. (2021). Relevance of dietary glycemic index, glycemic load and fiber intake before and during pregnancy for the risk of gestational diabetes mellitus and maternal glucose homeostasis. Clinical Nutrition, 2791–2799. https://doi.org/10.1016/j.clnu.2021.03.041","ieee":"X. Zhang et al., “Relevance of dietary glycemic index, glycemic load and fiber intake before and during pregnancy for the risk of gestational diabetes mellitus and maternal glucose homeostasis,” Clinical Nutrition, pp. 2791–2799, 2021, doi: 10.1016/j.clnu.2021.03.041.","chicago":"Zhang, Xiao, Yunhui Gong, Karen Della Corte, Dianke Yu, Hongmei Xue, Shufang Shan, Guo Tian, et al. “Relevance of Dietary Glycemic Index, Glycemic Load and Fiber Intake before and during Pregnancy for the Risk of Gestational Diabetes Mellitus and Maternal Glucose Homeostasis.” Clinical Nutrition, 2021, 2791–99. https://doi.org/10.1016/j.clnu.2021.03.041.","short":"X. Zhang, Y. Gong, K. Della Corte, D. Yu, H. Xue, S. Shan, G. Tian, Y. Liang, J. Zhang, F. He, D. Yang, R. Zhou, W. Bao, A. Buyken, G. Cheng, Clinical Nutrition (2021) 2791–2799.","mla":"Zhang, Xiao, et al. “Relevance of Dietary Glycemic Index, Glycemic Load and Fiber Intake before and during Pregnancy for the Risk of Gestational Diabetes Mellitus and Maternal Glucose Homeostasis.” Clinical Nutrition, 2021, pp. 2791–99, doi:10.1016/j.clnu.2021.03.041.","ama":"Zhang X, Gong Y, Della Corte K, et al. Relevance of dietary glycemic index, glycemic load and fiber intake before and during pregnancy for the risk of gestational diabetes mellitus and maternal glucose homeostasis. Clinical Nutrition. Published online 2021:2791-2799. doi:10.1016/j.clnu.2021.03.041","bibtex":"@article{Zhang_Gong_Della Corte_Yu_Xue_Shan_Tian_Liang_Zhang_He_et al._2021, title={Relevance of dietary glycemic index, glycemic load and fiber intake before and during pregnancy for the risk of gestational diabetes mellitus and maternal glucose homeostasis}, DOI={10.1016/j.clnu.2021.03.041}, journal={Clinical Nutrition}, author={Zhang, Xiao and Gong, Yunhui and Della Corte, Karen and Yu, Dianke and Xue, Hongmei and Shan, Shufang and Tian, Guo and Liang, Yi and Zhang, Jieyi and He, Fang and et al.}, year={2021}, pages={2791–2799} }"},"publication":"Clinical Nutrition"},{"publication":"Nutrition, Metabolism and Cardiovascular Diseases","citation":{"mla":"Nyasordzi, Juliana, et al. “Early Life Factors and Their Relevance for Markers of Cardiometabolic Risk in Early Adulthood.” Nutrition, Metabolism and Cardiovascular Diseases, 2021, pp. 2109–21, doi:10.1016/j.numecd.2021.03.024.","ama":"Nyasordzi J, Conrad J, Goletzke J, et al. Early life factors and their relevance for markers of cardiometabolic risk in early adulthood. Nutrition, Metabolism and Cardiovascular Diseases. Published online 2021:2109-2121. doi:10.1016/j.numecd.2021.03.024","bibtex":"@article{Nyasordzi_Conrad_Goletzke_Ludwig-Walz_Herder_Roden_Wudy_Hua_Remer_Buyken_2021, title={Early life factors and their relevance for markers of cardiometabolic risk in early adulthood}, DOI={10.1016/j.numecd.2021.03.024}, journal={Nutrition, Metabolism and Cardiovascular Diseases}, author={Nyasordzi, Juliana and Conrad, Johanna and Goletzke, Janina and Ludwig-Walz, Helena and Herder, Christian and Roden, Michael and Wudy, Stefan A. and Hua, Yifan and Remer, Thomas and Buyken, Anette}, year={2021}, pages={2109–2121} }","apa":"Nyasordzi, J., Conrad, J., Goletzke, J., Ludwig-Walz, H., Herder, C., Roden, M., Wudy, S. A., Hua, Y., Remer, T., & Buyken, A. (2021). Early life factors and their relevance for markers of cardiometabolic risk in early adulthood. Nutrition, Metabolism and Cardiovascular Diseases, 2109–2121. https://doi.org/10.1016/j.numecd.2021.03.024","ieee":"J. Nyasordzi et al., “Early life factors and their relevance for markers of cardiometabolic risk in early adulthood,” Nutrition, Metabolism and Cardiovascular Diseases, pp. 2109–2121, 2021, doi: 10.1016/j.numecd.2021.03.024.","short":"J. Nyasordzi, J. Conrad, J. Goletzke, H. Ludwig-Walz, C. Herder, M. Roden, S.A. Wudy, Y. Hua, T. Remer, A. Buyken, Nutrition, Metabolism and Cardiovascular Diseases (2021) 2109–2121.","chicago":"Nyasordzi, Juliana, Johanna Conrad, Janina Goletzke, Helena Ludwig-Walz, Christian Herder, Michael Roden, Stefan A. Wudy, Yifan Hua, Thomas Remer, and Anette Buyken. “Early Life Factors and Their Relevance for Markers of Cardiometabolic Risk in Early Adulthood.” Nutrition, Metabolism and Cardiovascular Diseases, 2021, 2109–21. https://doi.org/10.1016/j.numecd.2021.03.024."},"type":"journal_article","department":[{"_id":"17"},{"_id":"22"},{"_id":"571"}],"date_created":"2021-11-25T11:58:35Z","publication_status":"published","date_updated":"2022-01-06T06:57:45Z","title":"Early life factors and their relevance for markers of cardiometabolic risk in early adulthood","status":"public","year":"2021","author":[{"first_name":"Juliana","last_name":"Nyasordzi","full_name":"Nyasordzi, Juliana"},{"first_name":"Johanna","last_name":"Conrad","full_name":"Conrad, Johanna"},{"full_name":"Goletzke, Janina","first_name":"Janina","last_name":"Goletzke"},{"last_name":"Ludwig-Walz","first_name":"Helena","full_name":"Ludwig-Walz, Helena"},{"full_name":"Herder, Christian","first_name":"Christian","last_name":"Herder"},{"last_name":"Roden","first_name":"Michael","full_name":"Roden, Michael"},{"first_name":"Stefan A.","last_name":"Wudy","full_name":"Wudy, Stefan A."},{"first_name":"Yifan","last_name":"Hua","full_name":"Hua, Yifan"},{"full_name":"Remer, Thomas","last_name":"Remer","first_name":"Thomas"},{"id":"65985","first_name":"Anette","last_name":"Buyken","full_name":"Buyken, Anette"}],"publication_identifier":{"issn":["0939-4753"]},"user_id":"61597","doi":"10.1016/j.numecd.2021.03.024","page":"2109-2121","_id":"27790","language":[{"iso":"eng"}]},{"citation":{"ieee":"F. S. Atkinson, J. C. Brand-Miller, K. Foster-Powell, A. Buyken, and J. Goletzke, “International tables of glycemic index and glycemic load values 2021: a systematic review,” The American Journal of Clinical Nutrition, pp. 1625–1632, 2021, doi: 10.1093/ajcn/nqab233.","apa":"Atkinson, F. S., Brand-Miller, J. C., Foster-Powell, K., Buyken, A., & Goletzke, J. (2021). International tables of glycemic index and glycemic load values 2021: a systematic review. The American Journal of Clinical Nutrition, 1625–1632. https://doi.org/10.1093/ajcn/nqab233","short":"F.S. Atkinson, J.C. Brand-Miller, K. Foster-Powell, A. Buyken, J. Goletzke, The American Journal of Clinical Nutrition (2021) 1625–1632.","chicago":"Atkinson, Fiona S, Jennie C Brand-Miller, Kaye Foster-Powell, Anette Buyken, and Janina Goletzke. “International Tables of Glycemic Index and Glycemic Load Values 2021: A Systematic Review.” The American Journal of Clinical Nutrition, 2021, 1625–32. https://doi.org/10.1093/ajcn/nqab233.","mla":"Atkinson, Fiona S., et al. “International Tables of Glycemic Index and Glycemic Load Values 2021: A Systematic Review.” The American Journal of Clinical Nutrition, 2021, pp. 1625–32, doi:10.1093/ajcn/nqab233.","bibtex":"@article{Atkinson_Brand-Miller_Foster-Powell_Buyken_Goletzke_2021, title={International tables of glycemic index and glycemic load values 2021: a systematic review}, DOI={10.1093/ajcn/nqab233}, journal={The American Journal of Clinical Nutrition}, author={Atkinson, Fiona S and Brand-Miller, Jennie C and Foster-Powell, Kaye and Buyken, Anette and Goletzke, Janina}, year={2021}, pages={1625–1632} }","ama":"Atkinson FS, Brand-Miller JC, Foster-Powell K, Buyken A, Goletzke J. International tables of glycemic index and glycemic load values 2021: a systematic review. The American Journal of Clinical Nutrition. Published online 2021:1625-1632. doi:10.1093/ajcn/nqab233"},"publication":"The American Journal of Clinical Nutrition","abstract":[{"lang":"eng","text":"ABSTRACT\r\n \r\n Background\r\n Reliable tables of glycemic indexes (GIs) and glycemic loads (GLs) are critical to research examining the relationship between glycemic qualities of carbohydrate in foods, diets, and health. In the 12 years since the last edition of the tables, a large amount of new data has become available.\r\n \r\n \r\n Objectives\r\n To systematically review and tabulate published and unpublished sources of reliable GI values, including an assessment of the reliability of the data.\r\n \r\n \r\n Methods\r\n This edition of the tables lists over 4000 items, a 61% increase in the number of entries compared to the 2008 edition. The data have been separated into 2 lists. The first represents more precise values derived using the methodology recommended by the International Standards Organization (∼2100 items). The second list contains values determined using less robust methods, including using limited numbers of healthy subjects or with a large SEM (∼1900 food items).\r\n \r\n \r\n Results\r\n Dairy products, legumes, pasta, and fruits were usually low-GI foods (≤55 on the 100-point glucose scale) and had consistent values around the world. Cereals and cereal products, however, including whole-grain or whole-meal versions, showed wide variation in GI values, presumably arising from variations in manufacturing methods. Breads, breakfast cereals, rice, savory snack products, and regional foods were available in high-, medium-, and low-GI versions. Most varieties of potato were high-GI foods, but specific low-GI varieties have now been identified.\r\n \r\n \r\n Conclusions\r\n The availability of new data on the GIs of foods will facilitate wider research and application of the twin concepts of GI and GL. Although the 2021 edition of the tables improves the quality and quantity of GI data available for research and clinical practice, GI testing of regional foods remains a priority. This systematic review was registered in PROSPERO as #171204.\r\n "}],"date_created":"2021-11-25T12:01:37Z","department":[{"_id":"17"},{"_id":"22"},{"_id":"571"}],"type":"journal_article","publication_identifier":{"issn":["0002-9165","1938-3207"]},"author":[{"first_name":"Fiona S","last_name":"Atkinson","full_name":"Atkinson, Fiona S"},{"first_name":"Jennie C","last_name":"Brand-Miller","full_name":"Brand-Miller, Jennie C"},{"full_name":"Foster-Powell, Kaye","first_name":"Kaye","last_name":"Foster-Powell"},{"id":"65985","first_name":"Anette","last_name":"Buyken","full_name":"Buyken, Anette"},{"last_name":"Goletzke","first_name":"Janina","full_name":"Goletzke, Janina"}],"title":"International tables of glycemic index and glycemic load values 2021: a systematic review","status":"public","year":"2021","publication_status":"published","date_updated":"2022-01-06T06:57:45Z","language":[{"iso":"eng"}],"_id":"27793","page":"1625-1632","user_id":"61597","doi":"10.1093/ajcn/nqab233"},{"user_id":"35756","doi":"10.1186/s12984-021-00822-6","_id":"21264","language":[{"iso":"eng"}],"publication_status":"published","date_updated":"2022-01-06T06:54:52Z","publication_identifier":{"issn":["1743-0003"]},"author":[{"full_name":"Boschmann, Alexander","last_name":"Boschmann","first_name":"Alexander"},{"last_name":"Neuhaus","first_name":"Dorothee","full_name":"Neuhaus, Dorothee"},{"full_name":"Vogt, Sarah","last_name":"Vogt","first_name":"Sarah"},{"first_name":"Christian","last_name":"Kaltschmidt","full_name":"Kaltschmidt, Christian"},{"full_name":"Platzner, Marco","first_name":"Marco","last_name":"Platzner"},{"full_name":"Dosen, Strahinja","first_name":"Strahinja","last_name":"Dosen"}],"status":"public","title":"Immersive augmented reality system for the training of pattern classification control with a myoelectric prosthesis","year":"2021","type":"journal_article","date_created":"2021-02-22T10:43:02Z","abstract":[{"lang":"eng","text":"Abstract\n Background\n Hand amputation can have a truly debilitating impact on the life of the affected person. A multifunctional myoelectric prosthesis controlled using pattern classification can be used to restore some of the lost motor abilities. However, learning to control an advanced prosthesis can be a challenging task, but virtual and augmented reality (AR) provide means to create an engaging and motivating training.\n \n Methods\n In this study, we present a novel training framework that integrates virtual elements within a real scene (AR) while allowing the view from the first-person perspective. The framework was evaluated in 13 able-bodied subjects and a limb-deficient person divided into intervention (IG) and control (CG) groups. The IG received training by performing simulated clothespin task and both groups conducted a pre- and posttest with a real prosthesis. When training with the AR, the subjects received visual feedback on the generated grasping force. The main outcome measure was the number of pins that were successfully transferred within 20 min (task duration), while the number of dropped and broken pins were also registered. The participants were asked to score the difficulty of the real task (posttest), fun-factor and motivation, as well as the utility of the feedback.\n \n Results\n The performance (median/interquartile range) consistently increased during the training sessions (4/3 to 22/4). While the results were similar for the two groups in the pretest, the performance improved in the posttest only in IG. In addition, the subjects in IG transferred significantly more pins (28/10.5 versus 14.5/11), and dropped (1/2.5 versus 3.5/2) and broke (5/3.8 versus 14.5/9) significantly fewer pins in the posttest compared to CG. The participants in IG assigned (mean ± std) significantly lower scores to the difficulty compared to CG (5.2 ± 1.9 versus 7.1 ± 0.9), and they highly rated the fun factor (8.7 ± 1.3) and usefulness of feedback (8.5 ± 1.7).\n \n Conclusion\n The results demonstrated that the proposed AR system allows for the transfer of skills from the simulated to the real task while providing a positive user experience. The present study demonstrates the effectiveness and flexibility of the proposed AR framework. Importantly, the developed system is open source and available for download and further development.\n "}],"citation":{"mla":"Boschmann, Alexander, et al. “Immersive Augmented Reality System for the Training of Pattern Classification Control with a Myoelectric Prosthesis.” Journal of NeuroEngineering and Rehabilitation, 2021, doi:10.1186/s12984-021-00822-6.","bibtex":"@article{Boschmann_Neuhaus_Vogt_Kaltschmidt_Platzner_Dosen_2021, title={Immersive augmented reality system for the training of pattern classification control with a myoelectric prosthesis}, DOI={10.1186/s12984-021-00822-6}, journal={Journal of NeuroEngineering and Rehabilitation}, author={Boschmann, Alexander and Neuhaus, Dorothee and Vogt, Sarah and Kaltschmidt, Christian and Platzner, Marco and Dosen, Strahinja}, year={2021} }","ama":"Boschmann A, Neuhaus D, Vogt S, Kaltschmidt C, Platzner M, Dosen S. Immersive augmented reality system for the training of pattern classification control with a myoelectric prosthesis. Journal of NeuroEngineering and Rehabilitation. 2021. doi:10.1186/s12984-021-00822-6","ieee":"A. Boschmann, D. Neuhaus, S. Vogt, C. Kaltschmidt, M. Platzner, and S. Dosen, “Immersive augmented reality system for the training of pattern classification control with a myoelectric prosthesis,” Journal of NeuroEngineering and Rehabilitation, 2021.","apa":"Boschmann, A., Neuhaus, D., Vogt, S., Kaltschmidt, C., Platzner, M., & Dosen, S. (2021). Immersive augmented reality system for the training of pattern classification control with a myoelectric prosthesis. Journal of NeuroEngineering and Rehabilitation. https://doi.org/10.1186/s12984-021-00822-6","short":"A. Boschmann, D. Neuhaus, S. Vogt, C. Kaltschmidt, M. Platzner, S. Dosen, Journal of NeuroEngineering and Rehabilitation (2021).","chicago":"Boschmann, Alexander, Dorothee Neuhaus, Sarah Vogt, Christian Kaltschmidt, Marco Platzner, and Strahinja Dosen. “Immersive Augmented Reality System for the Training of Pattern Classification Control with a Myoelectric Prosthesis.” Journal of NeuroEngineering and Rehabilitation, 2021. https://doi.org/10.1186/s12984-021-00822-6."},"publication":"Journal of NeuroEngineering and Rehabilitation"},{"doi":"10.1093/nar/gkab097","user_id":"48864","volume":49,"page":"3048-3062","language":[{"iso":"eng"}],"_id":"22637","date_updated":"2022-01-06T06:55:37Z","publication_status":"published","intvolume":" 49","year":"2021","title":"Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release","status":"public","publication_identifier":{"issn":["0305-1048","1362-4962"]},"author":[{"first_name":"Heini","last_name":"Ijäs","full_name":"Ijäs, Heini"},{"first_name":"Boxuan","last_name":"Shen","full_name":"Shen, Boxuan"},{"first_name":"Amelie","last_name":"Heuer-Jungemann","full_name":"Heuer-Jungemann, Amelie"},{"id":"48864","first_name":"Adrian","last_name":"Keller","orcid":"0000-0001-7139-3110","full_name":"Keller, Adrian"},{"last_name":"Kostiainen","first_name":"Mauri A","full_name":"Kostiainen, Mauri A"},{"first_name":"Tim","last_name":"Liedl","full_name":"Liedl, Tim"},{"full_name":"Ihalainen, Janne A","last_name":"Ihalainen","first_name":"Janne A"},{"full_name":"Linko, Veikko","last_name":"Linko","first_name":"Veikko"}],"type":"journal_article","department":[{"_id":"302"}],"date_created":"2021-07-08T11:46:53Z","abstract":[{"text":"Abstract\r\n Doxorubicin (DOX) is a common drug in cancer chemotherapy, and its high DNA-binding affinity can be harnessed in preparing DOX-loaded DNA nanostructures for targeted delivery and therapeutics. Although DOX has been widely studied, the existing literature of DOX-loaded DNA-carriers remains limited and incoherent. Here, based on an in-depth spectroscopic analysis, we characterize and optimize the DOX loading into different 2D and 3D scaffolded DNA origami nanostructures (DONs). In our experimental conditions, all DONs show similar DOX binding capacities (one DOX molecule per two to three base pairs), and the binding equilibrium is reached within seconds, remarkably faster than previously acknowledged. To characterize drug release profiles, DON degradation and DOX release from the complexes upon DNase I digestion was studied. For the employed DONs, the relative doses (DOX molecules released per unit time) may vary by two orders of magnitude depending on the DON superstructure. In addition, we identify DOX aggregation mechanisms and spectral changes linked to pH, magnesium, and DOX concentration. These features have been largely ignored in experimenting with DNA nanostructures, but are probably the major sources of the incoherence of the experimental results so far. Therefore, we believe this work can act as a guide to tailoring the release profiles and developing better drug delivery systems based on DNA-carriers.","lang":"eng"}],"publication":"Nucleic Acids Research","citation":{"bibtex":"@article{Ijäs_Shen_Heuer-Jungemann_Keller_Kostiainen_Liedl_Ihalainen_Linko_2021, title={Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release}, volume={49}, DOI={10.1093/nar/gkab097}, journal={Nucleic Acids Research}, author={Ijäs, Heini and Shen, Boxuan and Heuer-Jungemann, Amelie and Keller, Adrian and Kostiainen, Mauri A and Liedl, Tim and Ihalainen, Janne A and Linko, Veikko}, year={2021}, pages={3048–3062} }","ama":"Ijäs H, Shen B, Heuer-Jungemann A, et al. Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release. Nucleic Acids Research. 2021;49:3048-3062. doi:10.1093/nar/gkab097","mla":"Ijäs, Heini, et al. “Unraveling the Interaction between Doxorubicin and DNA Origami Nanostructures for Customizable Chemotherapeutic Drug Release.” Nucleic Acids Research, vol. 49, 2021, pp. 3048–62, doi:10.1093/nar/gkab097.","short":"H. Ijäs, B. Shen, A. Heuer-Jungemann, A. Keller, M.A. Kostiainen, T. Liedl, J.A. Ihalainen, V. Linko, Nucleic Acids Research 49 (2021) 3048–3062.","chicago":"Ijäs, Heini, Boxuan Shen, Amelie Heuer-Jungemann, Adrian Keller, Mauri A Kostiainen, Tim Liedl, Janne A Ihalainen, and Veikko Linko. “Unraveling the Interaction between Doxorubicin and DNA Origami Nanostructures for Customizable Chemotherapeutic Drug Release.” Nucleic Acids Research 49 (2021): 3048–62. https://doi.org/10.1093/nar/gkab097.","ieee":"H. Ijäs et al., “Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release,” Nucleic Acids Research, vol. 49, pp. 3048–3062, 2021.","apa":"Ijäs, H., Shen, B., Heuer-Jungemann, A., Keller, A., Kostiainen, M. A., Liedl, T., … Linko, V. (2021). Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release. Nucleic Acids Research, 49, 3048–3062. https://doi.org/10.1093/nar/gkab097"}},{"author":[{"first_name":"Yang","last_name":"Xin","full_name":"Xin, Yang"},{"full_name":"Zargariantabrizi, Amir Ardalan","last_name":"Zargariantabrizi","first_name":"Amir Ardalan"},{"first_name":"Guido","last_name":"Grundmeier","full_name":"Grundmeier, Guido","id":"194"},{"id":"48864","full_name":"Keller, Adrian","first_name":"Adrian","orcid":"0000-0001-7139-3110","last_name":"Keller"}],"publication_identifier":{"issn":["1420-3049"]},"status":"public","year":"2021","title":"Magnesium-Free Immobilization of DNA Origami Nanostructures at Mica Surfaces for Atomic Force Microscopy","intvolume":" 26","publication_status":"published","date_updated":"2022-01-06T06:55:45Z","language":[{"iso":"eng"}],"_id":"23023","page":"4798","volume":26,"user_id":"48864","doi":"10.3390/molecules26164798","citation":{"short":"Y. Xin, A.A. Zargariantabrizi, G. Grundmeier, A. Keller, Molecules 26 (2021) 4798.","chicago":"Xin, Yang, Amir Ardalan Zargariantabrizi, Guido Grundmeier, and Adrian Keller. “Magnesium-Free Immobilization of DNA Origami Nanostructures at Mica Surfaces for Atomic Force Microscopy.” Molecules 26 (2021): 4798. https://doi.org/10.3390/molecules26164798.","apa":"Xin, Y., Zargariantabrizi, A. A., Grundmeier, G., & Keller, A. (2021). Magnesium-Free Immobilization of DNA Origami Nanostructures at Mica Surfaces for Atomic Force Microscopy. Molecules, 26, 4798. https://doi.org/10.3390/molecules26164798","ieee":"Y. Xin, A. A. Zargariantabrizi, G. Grundmeier, and A. Keller, “Magnesium-Free Immobilization of DNA Origami Nanostructures at Mica Surfaces for Atomic Force Microscopy,” Molecules, vol. 26, p. 4798, 2021.","ama":"Xin Y, Zargariantabrizi AA, Grundmeier G, Keller A. Magnesium-Free Immobilization of DNA Origami Nanostructures at Mica Surfaces for Atomic Force Microscopy. Molecules. 2021;26:4798. doi:10.3390/molecules26164798","bibtex":"@article{Xin_Zargariantabrizi_Grundmeier_Keller_2021, title={Magnesium-Free Immobilization of DNA Origami Nanostructures at Mica Surfaces for Atomic Force Microscopy}, volume={26}, DOI={10.3390/molecules26164798}, journal={Molecules}, author={Xin, Yang and Zargariantabrizi, Amir Ardalan and Grundmeier, Guido and Keller, Adrian}, year={2021}, pages={4798} }","mla":"Xin, Yang, et al. “Magnesium-Free Immobilization of DNA Origami Nanostructures at Mica Surfaces for Atomic Force Microscopy.” Molecules, vol. 26, 2021, p. 4798, doi:10.3390/molecules26164798."},"publication":"Molecules","abstract":[{"text":"DNA origami nanostructures (DONs) are promising substrates for the single-molecule investigation of biomolecular reactions and dynamics by in situ atomic force microscopy (AFM). For this, they are typically immobilized on mica substrates by adding millimolar concentrations of Mg2+ ions to the sample solution, which enable the adsorption of the negatively charged DONs at the like-charged mica surface. These non-physiological Mg2+ concentrations, however, present a serious limitation in such experiments as they may interfere with the reactions and processes under investigation. Therefore, we here evaluate three approaches to efficiently immobilize DONs at mica surfaces under essentially Mg2+-free conditions. These approaches rely on the pre-adsorption of different multivalent cations, i.e., Ni2+, poly-l-lysine (PLL), and spermidine (Spdn). DON adsorption is studied in phosphate-buffered saline (PBS) and pure water. In general, Ni2+ shows the worst performance with heavily deformed DONs. For 2D DON triangles, adsorption at PLL- and in particular Spdn-modified mica may outperform even Mg2+-mediated adsorption in terms of surface coverage, depending on the employed solution. For 3D six-helix bundles, less pronounced differences between the individual strategies are observed. Our results provide some general guidance for the immobilization of DONs at mica surfaces under Mg2+-free conditions and may aid future in situ AFM studies.","lang":"eng"}],"date_created":"2021-08-09T06:17:59Z","department":[{"_id":"302"}],"type":"journal_article"},{"citation":{"mla":"Boschmann, Alexander, et al. “Immersive Augmented Reality System for the Training of Pattern Classification Control with a Myoelectric Prosthesis.” Journal of NeuroEngineering and Rehabilitation, vol. 18, no. 1, 25, Springer Science and Business Media LLC, 2021, doi:10.1186/s12984-021-00822-6.","ama":"Boschmann A, Neuhaus D, Vogt S, Kaltschmidt C, Platzner M, Dosen S. Immersive augmented reality system for the training of pattern classification control with a myoelectric prosthesis. Journal of NeuroEngineering and Rehabilitation. 2021;18(1). doi:10.1186/s12984-021-00822-6","bibtex":"@article{Boschmann_Neuhaus_Vogt_Kaltschmidt_Platzner_Dosen_2021, title={Immersive augmented reality system for the training of pattern classification control with a myoelectric prosthesis}, volume={18}, DOI={10.1186/s12984-021-00822-6}, number={125}, journal={Journal of NeuroEngineering and Rehabilitation}, publisher={Springer Science and Business Media LLC}, author={Boschmann, Alexander and Neuhaus, Dorothee and Vogt, Sarah and Kaltschmidt, Christian and Platzner, Marco and Dosen, Strahinja}, year={2021} }","apa":"Boschmann, A., Neuhaus, D., Vogt, S., Kaltschmidt, C., Platzner, M., & Dosen, S. (2021). Immersive augmented reality system for the training of pattern classification control with a myoelectric prosthesis. Journal of NeuroEngineering and Rehabilitation, 18(1), Article 25. https://doi.org/10.1186/s12984-021-00822-6","ieee":"A. Boschmann, D. Neuhaus, S. Vogt, C. Kaltschmidt, M. Platzner, and S. Dosen, “Immersive augmented reality system for the training of pattern classification control with a myoelectric prosthesis,” Journal of NeuroEngineering and Rehabilitation, vol. 18, no. 1, Art. no. 25, 2021, doi: 10.1186/s12984-021-00822-6.","short":"A. Boschmann, D. Neuhaus, S. Vogt, C. Kaltschmidt, M. Platzner, S. Dosen, Journal of NeuroEngineering and Rehabilitation 18 (2021).","chicago":"Boschmann, Alexander, Dorothee Neuhaus, Sarah Vogt, Christian Kaltschmidt, Marco Platzner, and Strahinja Dosen. “Immersive Augmented Reality System for the Training of Pattern Classification Control with a Myoelectric Prosthesis.” Journal of NeuroEngineering and Rehabilitation 18, no. 1 (2021). https://doi.org/10.1186/s12984-021-00822-6."},"status":"public","volume":18,"user_id":"398","publisher":"Springer Science and Business Media LLC","_id":"30906","abstract":[{"text":"Abstract\r\n Background\r\n Hand amputation can have a truly debilitating impact on the life of the affected person. A multifunctional myoelectric prosthesis controlled using pattern classification can be used to restore some of the lost motor abilities. However, learning to control an advanced prosthesis can be a challenging task, but virtual and augmented reality (AR) provide means to create an engaging and motivating training.\r\n \r\n Methods\r\n In this study, we present a novel training framework that integrates virtual elements within a real scene (AR) while allowing the view from the first-person perspective. The framework was evaluated in 13 able-bodied subjects and a limb-deficient person divided into intervention (IG) and control (CG) groups. The IG received training by performing simulated clothespin task and both groups conducted a pre- and posttest with a real prosthesis. When training with the AR, the subjects received visual feedback on the generated grasping force. The main outcome measure was the number of pins that were successfully transferred within 20 min (task duration), while the number of dropped and broken pins were also registered. The participants were asked to score the difficulty of the real task (posttest), fun-factor and motivation, as well as the utility of the feedback.\r\n \r\n Results\r\n The performance (median/interquartile range) consistently increased during the training sessions (4/3 to 22/4). While the results were similar for the two groups in the pretest, the performance improved in the posttest only in IG. In addition, the subjects in IG transferred significantly more pins (28/10.5 versus 14.5/11), and dropped (1/2.5 versus 3.5/2) and broke (5/3.8 versus 14.5/9) significantly fewer pins in the posttest compared to CG. The participants in IG assigned (mean ± std) significantly lower scores to the difficulty compared to CG (5.2 ± 1.9 versus 7.1 ± 0.9), and they highly rated the fun factor (8.7 ± 1.3) and usefulness of feedback (8.5 ± 1.7).\r\n \r\n Conclusion\r\n The results demonstrated that the proposed AR system allows for the transfer of skills from the simulated to the real task while providing a positive user experience. The present study demonstrates the effectiveness and flexibility of the proposed AR framework. Importantly, the developed system is open source and available for download and further development.\r\n ","lang":"eng"}],"publication":"Journal of NeuroEngineering and Rehabilitation","issue":"1","department":[{"_id":"78"}],"keyword":["Health Informatics","Rehabilitation"],"type":"journal_article","date_created":"2022-04-18T10:02:20Z","intvolume":" 18","publication_status":"published","date_updated":"2022-04-18T10:04:16Z","publication_identifier":{"issn":["1743-0003"]},"author":[{"last_name":"Boschmann","first_name":"Alexander","full_name":"Boschmann, Alexander"},{"full_name":"Neuhaus, Dorothee","last_name":"Neuhaus","first_name":"Dorothee"},{"full_name":"Vogt, Sarah","first_name":"Sarah","last_name":"Vogt"},{"last_name":"Kaltschmidt","first_name":"Christian","full_name":"Kaltschmidt, Christian"},{"id":"398","full_name":"Platzner, Marco","first_name":"Marco","last_name":"Platzner"},{"full_name":"Dosen, Strahinja","first_name":"Strahinja","last_name":"Dosen"}],"year":"2021","title":"Immersive augmented reality system for the training of pattern classification control with a myoelectric prosthesis","doi":"10.1186/s12984-021-00822-6","language":[{"iso":"eng"}],"article_number":"25"},{"publication":"Fahrzeug + Karosserie und kfz-betrieb (Hrsg,); Tagungsband zu den Würzburger Karosserie- und Schadenstagen 22./23. Oktober 2021","citation":{"bibtex":"@inproceedings{Wibbeke_Bartley_Chudalla_Meschut_2021, title={Fügen und Trennen von Kfz-Karosseriestrukturen in Leichtbauweise}, booktitle={Fahrzeug + Karosserie und kfz-betrieb (Hrsg,); Tagungsband zu den Würzburger Karosserie- und Schadenstagen 22./23. Oktober 2021}, author={Wibbeke, Tim Michael and Bartley, Auerélie and Chudalla, Nick and Meschut, Gerson}, year={2021} }","ama":"Wibbeke TM, Bartley A, Chudalla N, Meschut G. Fügen und Trennen von Kfz-Karosseriestrukturen in Leichtbauweise. In: Fahrzeug + Karosserie Und Kfz-Betrieb (Hrsg,); Tagungsband Zu Den Würzburger Karosserie- Und Schadenstagen 22./23. Oktober 2021. ; 2021.","mla":"Wibbeke, Tim Michael, et al. “Fügen Und Trennen von Kfz-Karosseriestrukturen in Leichtbauweise.” Fahrzeug + Karosserie Und Kfz-Betrieb (Hrsg,); Tagungsband Zu Den Würzburger Karosserie- Und Schadenstagen 22./23. Oktober 2021, 2021.","short":"T.M. Wibbeke, A. Bartley, N. Chudalla, G. Meschut, in: Fahrzeug + Karosserie Und Kfz-Betrieb (Hrsg,); Tagungsband Zu Den Würzburger Karosserie- Und Schadenstagen 22./23. Oktober 2021, 2021.","chicago":"Wibbeke, Tim Michael, Auerélie Bartley, Nick Chudalla, and Gerson Meschut. “Fügen Und Trennen von Kfz-Karosseriestrukturen in Leichtbauweise.” In Fahrzeug + Karosserie Und Kfz-Betrieb (Hrsg,); Tagungsband Zu Den Würzburger Karosserie- Und Schadenstagen 22./23. Oktober 2021, 2021.","ieee":"T. M. Wibbeke, A. Bartley, N. Chudalla, and G. Meschut, “Fügen und Trennen von Kfz-Karosseriestrukturen in Leichtbauweise,” 2021.","apa":"Wibbeke, T. M., Bartley, A., Chudalla, N., & Meschut, G. (2021). Fügen und Trennen von Kfz-Karosseriestrukturen in Leichtbauweise. Fahrzeug + Karosserie Und Kfz-Betrieb (Hrsg,); Tagungsband Zu Den Würzburger Karosserie- Und Schadenstagen 22./23. Oktober 2021."},"type":"conference","department":[{"_id":"43"},{"_id":"157"}],"date_created":"2021-10-25T12:05:22Z","date_updated":"2022-04-25T11:24:34Z","title":"Fügen und Trennen von Kfz-Karosseriestrukturen in Leichtbauweise","status":"public","year":"2021","author":[{"full_name":"Wibbeke, Tim Michael","last_name":"Wibbeke","first_name":"Tim Michael"},{"full_name":"Bartley, Auerélie","last_name":"Bartley","first_name":"Auerélie"},{"full_name":"Chudalla, Nick","last_name":"Chudalla","first_name":"Nick","id":"41235"},{"id":"32056","last_name":"Meschut","orcid":"0000-0002-2763-1246","first_name":"Gerson","full_name":"Meschut, Gerson"}],"user_id":"41235","language":[{"iso":"eng"}],"_id":"26821"},{"author":[{"full_name":"Ludwig-Walz, Helena","first_name":"Helena","last_name":"Ludwig-Walz"},{"full_name":"Nyasordzi, Juliana","last_name":"Nyasordzi","first_name":"Juliana"},{"full_name":"Weber, Katharina S.","last_name":"Weber","first_name":"Katharina S."},{"id":"65985","full_name":"Buyken, Anette","last_name":"Buyken","first_name":"Anette"},{"full_name":"Kroke, Anja","first_name":"Anja","last_name":"Kroke"}],"publication_identifier":{"issn":["0939-4753"]},"year":"2021","title":"Maternal pregnancy weight or gestational weight gain and offspring's blood pressure: A systematic review","intvolume":" 32","publication_status":"published","date_updated":"2022-08-18T10:41:47Z","language":[{"iso":"eng"}],"doi":"10.1016/j.numecd.2021.11.011","publication":"Nutrition, Metabolism and Cardiovascular Diseases","issue":"4","date_created":"2022-08-18T10:34:46Z","department":[{"_id":"17"},{"_id":"22"},{"_id":"571"}],"keyword":["Cardiology and Cardiovascular Medicine","Nutrition and Dietetics","Endocrinology","Diabetes and Metabolism","Medicine (miscellaneous)"],"type":"journal_article","status":"public","_id":"33008","publisher":"Elsevier BV","page":"833-852","volume":32,"user_id":"61597","citation":{"ieee":"H. Ludwig-Walz, J. Nyasordzi, K. S. Weber, A. Buyken, and A. Kroke, “Maternal pregnancy weight or gestational weight gain and offspring’s blood pressure: A systematic review,” Nutrition, Metabolism and Cardiovascular Diseases, vol. 32, no. 4, pp. 833–852, 2021, doi: 10.1016/j.numecd.2021.11.011.","apa":"Ludwig-Walz, H., Nyasordzi, J., Weber, K. S., Buyken, A., & Kroke, A. (2021). Maternal pregnancy weight or gestational weight gain and offspring’s blood pressure: A systematic review. Nutrition, Metabolism and Cardiovascular Diseases, 32(4), 833–852. https://doi.org/10.1016/j.numecd.2021.11.011","chicago":"Ludwig-Walz, Helena, Juliana Nyasordzi, Katharina S. Weber, Anette Buyken, and Anja Kroke. “Maternal Pregnancy Weight or Gestational Weight Gain and Offspring’s Blood Pressure: A Systematic Review.” Nutrition, Metabolism and Cardiovascular Diseases 32, no. 4 (2021): 833–52. https://doi.org/10.1016/j.numecd.2021.11.011.","short":"H. Ludwig-Walz, J. Nyasordzi, K.S. Weber, A. Buyken, A. Kroke, Nutrition, Metabolism and Cardiovascular Diseases 32 (2021) 833–852.","mla":"Ludwig-Walz, Helena, et al. “Maternal Pregnancy Weight or Gestational Weight Gain and Offspring’s Blood Pressure: A Systematic Review.” Nutrition, Metabolism and Cardiovascular Diseases, vol. 32, no. 4, Elsevier BV, 2021, pp. 833–52, doi:10.1016/j.numecd.2021.11.011.","bibtex":"@article{Ludwig-Walz_Nyasordzi_Weber_Buyken_Kroke_2021, title={Maternal pregnancy weight or gestational weight gain and offspring’s blood pressure: A systematic review}, volume={32}, DOI={10.1016/j.numecd.2021.11.011}, number={4}, journal={Nutrition, Metabolism and Cardiovascular Diseases}, publisher={Elsevier BV}, author={Ludwig-Walz, Helena and Nyasordzi, Juliana and Weber, Katharina S. and Buyken, Anette and Kroke, Anja}, year={2021}, pages={833–852} }","ama":"Ludwig-Walz H, Nyasordzi J, Weber KS, Buyken A, Kroke A. Maternal pregnancy weight or gestational weight gain and offspring’s blood pressure: A systematic review. Nutrition, Metabolism and Cardiovascular Diseases. 2021;32(4):833-852. doi:10.1016/j.numecd.2021.11.011"}},{"extern":"1","abstract":[{"text":"There is a distinct increase in the prevalence of depression with the onset of puberty. The role of peripubertal testosterone levels in boys in this context is insufficiently understood and may be modulated by a functional polymorphism of the androgen receptor gene (AR), a variable number of CAG repeats. Moreover, there is preliminary evidence that the relationship between testosterone, CAG repeat length, and the severity of depressive symptoms may differ between subclinical and overt depression, but this has neither been studied in a clinical sample of adolescents with depression nor compared between subclinical and overt depression in an adequately powered study. To investigate the relationship between free testosterone, CAG repeat length of the AR, depression status (subclinical vs. overt), and the severity of depressive symptoms, 118 boys treated as in- or daycare patients at a single psychiatric hospital were studied. Of these, 73 boys had at least mild depressive symptoms according to the Beck Depression Inventory-II (BDI-II > 13). Higher-order moderation analysis in the multiple regression framework revealed a constant relationship between free testosterone and depression severity irrespective of the number of CAG repeats in adolescents with a BDI-II score ≤ 13. In adolescents with a BDI-II score > 13, however, there was a significant negative relationship between free testosterone and BDI-II score in patients with <19 CAG repeats and a significant positive relationship regarding free testosterone and BDI-II score in those with more than 28 CAG repeats, even when considering important covariates. These results suggest that the effects of testosterone on mood in male adolescents with depression depend on the genetic make-up of the AR as well as on depression status. This complex relationship should be considered by future studies addressing mental health issues against an endocrine background and may, moreover, contribute to tailored treatment concepts in psychiatric medicine, especially in adults.","lang":"eng"}],"publication":"Frontiers in Psychiatry","citation":{"ama":"Hirtz R, Libuda L, Hinney A, et al. Size Matters: The CAG Repeat Length of the Androgen Receptor Gene, Testosterone, and Male Adolescent Depression Severity. Frontiers in Psychiatry. Published online 2021. doi:10.3389/fpsyt.2021.732759","bibtex":"@article{Hirtz_Libuda_Hinney_Föcker_Bühlmeier_Holterhus_Kulle_Kiewert_Hebebrand_Grasemann_2021, title={Size Matters: The CAG Repeat Length of the Androgen Receptor Gene, Testosterone, and Male Adolescent Depression Severity}, DOI={10.3389/fpsyt.2021.732759}, journal={Frontiers in Psychiatry}, author={Hirtz, Raphael and Libuda, Lars and Hinney, Anke and Föcker, Manuel and Bühlmeier, Judith and Holterhus, Paul-Martin and Kulle, Alexandra and Kiewert, Cordula and Hebebrand, Johannes and Grasemann, Corinna}, year={2021} }","mla":"Hirtz, Raphael, et al. “Size Matters: The CAG Repeat Length of the Androgen Receptor Gene, Testosterone, and Male Adolescent Depression Severity.” Frontiers in Psychiatry, 2021, doi:10.3389/fpsyt.2021.732759.","short":"R. Hirtz, L. Libuda, A. Hinney, M. Föcker, J. Bühlmeier, P.-M. Holterhus, A. Kulle, C. Kiewert, J. Hebebrand, C. Grasemann, Frontiers in Psychiatry (2021).","chicago":"Hirtz, Raphael, Lars Libuda, Anke Hinney, Manuel Föcker, Judith Bühlmeier, Paul-Martin Holterhus, Alexandra Kulle, Cordula Kiewert, Johannes Hebebrand, and Corinna Grasemann. “Size Matters: The CAG Repeat Length of the Androgen Receptor Gene, Testosterone, and Male Adolescent Depression Severity.” Frontiers in Psychiatry, 2021. https://doi.org/10.3389/fpsyt.2021.732759.","apa":"Hirtz, R., Libuda, L., Hinney, A., Föcker, M., Bühlmeier, J., Holterhus, P.-M., Kulle, A., Kiewert, C., Hebebrand, J., & Grasemann, C. (2021). Size Matters: The CAG Repeat Length of the Androgen Receptor Gene, Testosterone, and Male Adolescent Depression Severity. Frontiers in Psychiatry. https://doi.org/10.3389/fpsyt.2021.732759","ieee":"R. Hirtz et al., “Size Matters: The CAG Repeat Length of the Androgen Receptor Gene, Testosterone, and Male Adolescent Depression Severity,” Frontiers in Psychiatry, 2021, doi: 10.3389/fpsyt.2021.732759."},"type":"journal_article","department":[{"_id":"35"},{"_id":"22"},{"_id":"395"}],"date_created":"2021-11-18T19:57:38Z","publication_status":"published","date_updated":"2022-09-15T09:40:45Z","year":"2021","title":"Size Matters: The CAG Repeat Length of the Androgen Receptor Gene, Testosterone, and Male Adolescent Depression Severity","status":"public","publication_identifier":{"issn":["1664-0640"]},"author":[{"full_name":"Hirtz, Raphael","last_name":"Hirtz","first_name":"Raphael"},{"full_name":"Libuda, Lars","first_name":"Lars","last_name":"Libuda","orcid":"0000-0003-1603-3133","id":"88682"},{"full_name":"Hinney, Anke","first_name":"Anke","last_name":"Hinney"},{"full_name":"Föcker, Manuel","last_name":"Föcker","first_name":"Manuel"},{"full_name":"Bühlmeier, Judith","first_name":"Judith","last_name":"Bühlmeier"},{"last_name":"Holterhus","first_name":"Paul-Martin","full_name":"Holterhus, Paul-Martin"},{"last_name":"Kulle","first_name":"Alexandra","full_name":"Kulle, Alexandra"},{"full_name":"Kiewert, Cordula","last_name":"Kiewert","first_name":"Cordula"},{"full_name":"Hebebrand, Johannes","last_name":"Hebebrand","first_name":"Johannes"},{"full_name":"Grasemann, Corinna","last_name":"Grasemann","first_name":"Corinna"}],"user_id":"89838","doi":"10.3389/fpsyt.2021.732759","language":[{"iso":"eng"}],"_id":"27575"},{"abstract":[{"lang":"eng","text":"(1) Background: Evidence has accumulated that patients with anorexia nervosa (AN) are at higher risk for vitamin D deficiency than healthy controls. In epidemiologic studies, low 25(OH) vitamin D (25(OH)D) levels were associated with depression. This study analyzed the relationship between 25(OH)D serum levels in adolescent patients and AN and depressive symptoms over the course of treatment. (2) Methods: 25(OH)D levels and depressive symptoms were analyzed in 93 adolescent (in-)patients with AN from the Anorexia Nervosa Day patient versus Inpatient (ANDI) multicenter trial at clinic admission, discharge, and 1 year follow up. Mixed regression models were used to analyze the relationship between 25(OH)D levels and depressive symptoms assessed by the Beck Depression Inventory (BDI-II). (3) Results: Although mean 25(OH)D levels constantly remained in recommended ranges (≥50 nmol/L) during AN treatment, levels decreased from (in)patient admission to 1 year follow up. Levels of 25(OH)D were neither cross-sectionally, prospectively, nor longitudinally associated with the BDI-II score. (4) Conclusions: This study did not confirm that 25(OH)D levels are associated with depressive symptoms in patients with AN. However, increasing risks of vitamin D deficiency over the course of AN treatment indicate that clinicians should monitor 25(OH)D levels."}],"extern":"1","citation":{"mla":"Föcker, Manuel, et al. “Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms.” Nutrients, 2356, 2021, doi:10.3390/nu13072356.","ama":"Föcker M, Timmesfeld N, Bühlmeier J, et al. Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms. Nutrients. Published online 2021. doi:10.3390/nu13072356","bibtex":"@article{Föcker_Timmesfeld_Bühlmeier_Zwanziger_Führer_Grasemann_Ehrlich_Egberts_Fleischhaker_Wewetzer_et al._2021, title={Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms}, DOI={10.3390/nu13072356}, number={2356}, journal={Nutrients}, author={Föcker, Manuel and Timmesfeld, Nina and Bühlmeier, Judith and Zwanziger, Denise and Führer, Dagmar and Grasemann, Corinna and Ehrlich, Stefan and Egberts, Karin and Fleischhaker, Christian and Wewetzer, Christoph and et al.}, year={2021} }","apa":"Föcker, M., Timmesfeld, N., Bühlmeier, J., Zwanziger, D., Führer, D., Grasemann, C., Ehrlich, S., Egberts, K., Fleischhaker, C., Wewetzer, C., Wessing, I., Seitz, J., Herpertz-Dahlmann, B., Hebebrand, J., & Libuda, L. (2021). Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms. Nutrients, Article 2356. https://doi.org/10.3390/nu13072356","ieee":"M. Föcker et al., “Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms,” Nutrients, Art. no. 2356, 2021, doi: 10.3390/nu13072356.","short":"M. Föcker, N. Timmesfeld, J. Bühlmeier, D. Zwanziger, D. Führer, C. Grasemann, S. Ehrlich, K. Egberts, C. Fleischhaker, C. Wewetzer, I. Wessing, J. Seitz, B. Herpertz-Dahlmann, J. Hebebrand, L. Libuda, Nutrients (2021).","chicago":"Föcker, Manuel, Nina Timmesfeld, Judith Bühlmeier, Denise Zwanziger, Dagmar Führer, Corinna Grasemann, Stefan Ehrlich, et al. “Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms.” Nutrients, 2021. https://doi.org/10.3390/nu13072356."},"publication":"Nutrients","department":[{"_id":"35"},{"_id":"22"},{"_id":"395"}],"type":"journal_article","date_created":"2021-11-18T19:23:23Z","date_updated":"2022-09-15T09:42:11Z","publication_status":"published","publication_identifier":{"issn":["2072-6643"]},"author":[{"full_name":"Föcker, Manuel","last_name":"Föcker","first_name":"Manuel"},{"last_name":"Timmesfeld","first_name":"Nina","full_name":"Timmesfeld, Nina"},{"first_name":"Judith","last_name":"Bühlmeier","full_name":"Bühlmeier, Judith","id":"89838"},{"full_name":"Zwanziger, Denise","first_name":"Denise","last_name":"Zwanziger"},{"full_name":"Führer, Dagmar","last_name":"Führer","first_name":"Dagmar"},{"full_name":"Grasemann, Corinna","last_name":"Grasemann","first_name":"Corinna"},{"full_name":"Ehrlich, Stefan","last_name":"Ehrlich","first_name":"Stefan"},{"last_name":"Egberts","first_name":"Karin","full_name":"Egberts, Karin"},{"full_name":"Fleischhaker, Christian","last_name":"Fleischhaker","first_name":"Christian"},{"first_name":"Christoph","last_name":"Wewetzer","full_name":"Wewetzer, Christoph"},{"full_name":"Wessing, Ida","last_name":"Wessing","first_name":"Ida"},{"full_name":"Seitz, Jochen","first_name":"Jochen","last_name":"Seitz"},{"full_name":"Herpertz-Dahlmann, Beate","first_name":"Beate","last_name":"Herpertz-Dahlmann"},{"last_name":"Hebebrand","first_name":"Johannes","full_name":"Hebebrand, Johannes"},{"id":"88682","full_name":"Libuda, Lars","orcid":"0000-0003-1603-3133","first_name":"Lars","last_name":"Libuda"}],"title":"Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms","status":"public","year":"2021","doi":"10.3390/nu13072356","user_id":"89838","_id":"27571","language":[{"iso":"eng"}],"article_number":"2356"},{"citation":{"mla":"Freff, Jana, et al. “Alterations in B Cell Subsets Correlate with Body Composition Parameters in Female Adolescents with Anorexia Nervosa.” Scientific Reports, 2021, doi:10.1038/s41598-020-80693-4.","bibtex":"@article{Freff_Schwarte_Bröker_Bühlmeier_Kraft_Öztürk_Hinney_Arolt_Dannlowski_Romer_et al._2021, title={Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa}, DOI={10.1038/s41598-020-80693-4}, journal={Scientific Reports}, author={Freff, Jana and Schwarte, Kathrin and Bröker, Lisa and Bühlmeier, Judith and Kraft, Isabelle and Öztürk, Dana and Hinney, Anke and Arolt, Volker and Dannlowski, Udo and Romer, Georg and et al.}, year={2021} }","ama":"Freff J, Schwarte K, Bröker L, et al. Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa. Scientific Reports. Published online 2021. doi:10.1038/s41598-020-80693-4","ieee":"J. Freff et al., “Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa,” Scientific Reports, 2021, doi: 10.1038/s41598-020-80693-4.","apa":"Freff, J., Schwarte, K., Bröker, L., Bühlmeier, J., Kraft, I., Öztürk, D., Hinney, A., Arolt, V., Dannlowski, U., Romer, G., Baune, B. T., Hebebrand, J., Föcker, M., & Alferink, J. (2021). Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa. Scientific Reports. https://doi.org/10.1038/s41598-020-80693-4","chicago":"Freff, Jana, Kathrin Schwarte, Lisa Bröker, Judith Bühlmeier, Isabelle Kraft, Dana Öztürk, Anke Hinney, et al. “Alterations in B Cell Subsets Correlate with Body Composition Parameters in Female Adolescents with Anorexia Nervosa.” Scientific Reports, 2021. https://doi.org/10.1038/s41598-020-80693-4.","short":"J. Freff, K. Schwarte, L. Bröker, J. Bühlmeier, I. Kraft, D. Öztürk, A. Hinney, V. Arolt, U. Dannlowski, G. Romer, B.T. Baune, J. Hebebrand, M. Föcker, J. Alferink, Scientific Reports (2021)."},"publication":"Scientific Reports","extern":"1","abstract":[{"text":"AbstractAnorexia nervosa (AN) is a severe eating disorder and often associated with altered humoral immune responses. However, distinct B cell maturation stages in peripheral blood in adolescents with AN have not been characterized. Treatment effects and the relationship between clinical and B cell parameters are also not fully understood. Here we investigated the phenotype of circulating B cell subsets and the relationship with body composition in adolescents with AN before (T0, n = 24) and after 6 weeks (T1, n = 20) of treatment. Using multi-parameter flow cytometry, we found increased percentages of antigen-experienced B cells and plasmablasts in patients with AN compared to healthy controls (n = 20). In contrast, percentages of CD1d+CD5+ B cells and transitional B cells with immunoregulatory roles were reduced at T0 and T1. These B cell frequencies correlated positively with fat mass, fat mass index (FMI), free fat mass index, and body mass index standard deviation score. In addition, scavenger-like receptor CD5 expression levels were downregulated on transitional B cells and correlated with fat mass and FMI in AN. Our findings that regulatory B cell subgroups were reduced in AN and their strong relationship with body composition parameters point toward an impact of immunoregulatory B cells in the pathogenesis of AN.","lang":"eng"}],"date_created":"2021-10-20T18:56:17Z","department":[{"_id":"35"},{"_id":"22"},{"_id":"395"}],"type":"journal_article","author":[{"last_name":"Freff","first_name":"Jana","full_name":"Freff, Jana"},{"full_name":"Schwarte, Kathrin","last_name":"Schwarte","first_name":"Kathrin"},{"full_name":"Bröker, Lisa","first_name":"Lisa","last_name":"Bröker"},{"last_name":"Bühlmeier","first_name":"Judith","full_name":"Bühlmeier, Judith","id":"89838"},{"full_name":"Kraft, Isabelle","first_name":"Isabelle","last_name":"Kraft"},{"last_name":"Öztürk","first_name":"Dana","full_name":"Öztürk, Dana"},{"full_name":"Hinney, Anke","first_name":"Anke","last_name":"Hinney"},{"full_name":"Arolt, Volker","last_name":"Arolt","first_name":"Volker"},{"full_name":"Dannlowski, Udo","first_name":"Udo","last_name":"Dannlowski"},{"full_name":"Romer, Georg","first_name":"Georg","last_name":"Romer"},{"full_name":"Baune, Bernhard T.","last_name":"Baune","first_name":"Bernhard T."},{"full_name":"Hebebrand, Johannes","first_name":"Johannes","last_name":"Hebebrand"},{"last_name":"Föcker","first_name":"Manuel","full_name":"Föcker, Manuel"},{"first_name":"Judith","last_name":"Alferink","full_name":"Alferink, Judith"}],"publication_identifier":{"issn":["2045-2322"]},"title":"Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa","status":"public","year":"2021","publication_status":"published","date_updated":"2022-09-15T09:50:35Z","_id":"26632","language":[{"iso":"eng"}],"user_id":"89838","doi":"10.1038/s41598-020-80693-4"},{"extern":"1","publication":"Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie","citation":{"ieee":"J. Hebebrand et al., “Kurzzeitige Behandlung von Patient_innen mit Anorexia nervosa mit rekombinant hergestelltem Human-Leptin (Metreleptin): Rasch einsetzende positive Effekte auf Stimmung, Kognition und Verhalten,” Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, pp. 1–5, 2021, doi: 10.1024/1422-4917/a000775.","mla":"Hebebrand, Johannes, et al. “Kurzzeitige Behandlung von Patient_innen mit Anorexia nervosa mit rekombinant hergestelltem Human-Leptin (Metreleptin): Rasch einsetzende positive Effekte auf Stimmung, Kognition und Verhalten.” Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, 2021, pp. 1–5, doi:10.1024/1422-4917/a000775.","apa":"Hebebrand, J., Antel, J., Tan, S., Wabitsch, M., Wiesing, U., Barth, N., Ludwig, C., Bühlmeier, J., Libuda, L., Milos, G., & Hinney, A. (2021). Kurzzeitige Behandlung von Patient_innen mit Anorexia nervosa mit rekombinant hergestelltem Human-Leptin (Metreleptin): Rasch einsetzende positive Effekte auf Stimmung, Kognition und Verhalten. Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, 1–5. https://doi.org/10.1024/1422-4917/a000775","bibtex":"@article{Hebebrand_Antel_Tan_Wabitsch_Wiesing_Barth_Ludwig_Bühlmeier_Libuda_Milos_et al._2021, title={Kurzzeitige Behandlung von Patient_innen mit Anorexia nervosa mit rekombinant hergestelltem Human-Leptin (Metreleptin): Rasch einsetzende positive Effekte auf Stimmung, Kognition und Verhalten}, DOI={10.1024/1422-4917/a000775}, journal={Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie}, author={Hebebrand, Johannes and Antel, Jochen and Tan, Susanne and Wabitsch, Martin and Wiesing, Urban and Barth, Nikolaus and Ludwig, Christine and Bühlmeier, Judith and Libuda, Lars and Milos, Gabriella and et al.}, year={2021}, pages={1–5} }","short":"J. Hebebrand, J. Antel, S. Tan, M. Wabitsch, U. Wiesing, N. Barth, C. Ludwig, J. Bühlmeier, L. Libuda, G. Milos, A. Hinney, Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie (2021) 1–5.","ama":"Hebebrand J, Antel J, Tan S, et al. Kurzzeitige Behandlung von Patient_innen mit Anorexia nervosa mit rekombinant hergestelltem Human-Leptin (Metreleptin): Rasch einsetzende positive Effekte auf Stimmung, Kognition und Verhalten. Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie. Published online 2021:1-5. doi:10.1024/1422-4917/a000775","chicago":"Hebebrand, Johannes, Jochen Antel, Susanne Tan, Martin Wabitsch, Urban Wiesing, Nikolaus Barth, Christine Ludwig, et al. “Kurzzeitige Behandlung von Patient_innen mit Anorexia nervosa mit rekombinant hergestelltem Human-Leptin (Metreleptin): Rasch einsetzende positive Effekte auf Stimmung, Kognition und Verhalten.” Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, 2021, 1–5. https://doi.org/10.1024/1422-4917/a000775."},"type":"journal_article","department":[{"_id":"35"},{"_id":"22"}],"date_created":"2021-10-19T09:55:10Z","date_updated":"2022-09-15T09:50:49Z","publication_status":"published","status":"public","title":"Kurzzeitige Behandlung von Patient_innen mit Anorexia nervosa mit rekombinant hergestelltem Human-Leptin (Metreleptin): Rasch einsetzende positive Effekte auf Stimmung, Kognition und Verhalten","year":"2021","publication_identifier":{"issn":["1422-4917","1664-2880"]},"author":[{"full_name":"Hebebrand, Johannes","first_name":"Johannes","last_name":"Hebebrand"},{"last_name":"Antel","first_name":"Jochen","full_name":"Antel, Jochen"},{"last_name":"Tan","first_name":"Susanne","full_name":"Tan, Susanne"},{"full_name":"Wabitsch, Martin","first_name":"Martin","last_name":"Wabitsch"},{"full_name":"Wiesing, Urban","first_name":"Urban","last_name":"Wiesing"},{"last_name":"Barth","first_name":"Nikolaus","full_name":"Barth, Nikolaus"},{"full_name":"Ludwig, Christine","first_name":"Christine","last_name":"Ludwig"},{"first_name":"Judith","last_name":"Bühlmeier","full_name":"Bühlmeier, Judith","id":"89838"},{"full_name":"Libuda, Lars","last_name":"Libuda","first_name":"Lars","orcid":"0000-0003-1603-3133","id":"88682"},{"last_name":"Milos","first_name":"Gabriella","full_name":"Milos, Gabriella"},{"first_name":"Anke","last_name":"Hinney","full_name":"Hinney, Anke"}],"doi":"10.1024/1422-4917/a000775","user_id":"89838","page":"1-5","_id":"26525","language":[{"iso":"ger"}]},{"project":[{"grant_number":"418701707","_id":"130","name":"TRR 285: TRR 285"},{"name":"TRR 285 - C: TRR 285 - Project Area C","_id":"133"},{"_id":"148","name":"TRR 285 – C04: TRR 285 - Subproject C04"}],"abstract":[{"text":"When joining lightweight parts of various materials, clinching is a cost efficient solution. In a production line, the quality of a clinch point is primarily controlled by measurement of dimensions, which are accessible from outside. However, methods such as visual testing and measuring the bottom thickness as well as the outer diameter are not able to deliver any information about the most significant geometrical characteristic of the clinch point, neck thickness and undercut. Furthermore, ex-situ destructive methods such as microsectioning cannot detect elastic deformations and cracks that close after unloading. In order to exceed the current limits, a new non-destructive in-situ testing method for the clinching process is necessary. This work proposes a concept to characterize clinch points in-situ by combining two complementary non-destructive methods, namely, computed tomography (CT) and ultrasonic testing. Firstly, clinch points with different geometrical characteristics are analysed experimentally using ex-situ CT to get a highly spatially resolved 3D-image of the object. In this context, highly X-ray attenuating materials enhancing the visibility of the sheet-sheet interface are investigated. Secondly, the test specimens are modelled using finite element method (FEM) and a transient dynamic analysis (TDA) is conducted to study the effect of the geometrical differences on the deformation energy and to qualify the TDA as a fast in-situ non-destructive method for characterizing clinch points at high temporal resolution. ","lang":"eng"}],"citation":{"apa":"Köhler, D., Sadeghian, B., Kupfer, R., Troschitz, J., Gude, M., & Brosius, A. (2021). A Method for Characterization of Geometric Deviations in Clinch Points with Computed Tomography and Transient Dynamic Analysis. Key Engineering Materials, 883, 89–96. https://doi.org/10.4028/www.scientific.net/kem.883.89","ieee":"D. Köhler, B. Sadeghian, R. Kupfer, J. Troschitz, M. Gude, and A. Brosius, “A Method for Characterization of Geometric Deviations in Clinch Points with Computed Tomography and Transient Dynamic Analysis,” Key Engineering Materials, vol. 883, pp. 89–96, 2021, doi: 10.4028/www.scientific.net/kem.883.89.","chicago":"Köhler, D., B. Sadeghian, R. Kupfer, J. Troschitz, M. Gude, and A. Brosius. “A Method for Characterization of Geometric Deviations in Clinch Points with Computed Tomography and Transient Dynamic Analysis.” Key Engineering Materials 883 (2021): 89–96. https://doi.org/10.4028/www.scientific.net/kem.883.89.","short":"D. Köhler, B. Sadeghian, R. Kupfer, J. Troschitz, M. Gude, A. Brosius, Key Engineering Materials 883 (2021) 89–96.","mla":"Köhler, D., et al. “A Method for Characterization of Geometric Deviations in Clinch Points with Computed Tomography and Transient Dynamic Analysis.” Key Engineering Materials, vol. 883, 2021, pp. 89–96, doi:10.4028/www.scientific.net/kem.883.89.","ama":"Köhler D, Sadeghian B, Kupfer R, Troschitz J, Gude M, Brosius A. A Method for Characterization of Geometric Deviations in Clinch Points with Computed Tomography and Transient Dynamic Analysis. Key Engineering Materials. 2021;883:89-96. doi:10.4028/www.scientific.net/kem.883.89","bibtex":"@article{Köhler_Sadeghian_Kupfer_Troschitz_Gude_Brosius_2021, title={A Method for Characterization of Geometric Deviations in Clinch Points with Computed Tomography and Transient Dynamic Analysis}, volume={883}, DOI={10.4028/www.scientific.net/kem.883.89}, journal={Key Engineering Materials}, author={Köhler, D. and Sadeghian, B. and Kupfer, R. and Troschitz, J. and Gude, M. and Brosius, A.}, year={2021}, pages={89–96} }"},"publication":"Key Engineering Materials","department":[{"_id":"630"}],"type":"journal_article","date_created":"2022-03-29T08:46:40Z","intvolume":" 883","date_updated":"2023-01-02T11:48:16Z","author":[{"first_name":"D.","last_name":"Köhler","full_name":"Köhler, D."},{"last_name":"Sadeghian","first_name":"B.","full_name":"Sadeghian, B."},{"full_name":"Kupfer, R.","last_name":"Kupfer","first_name":"R."},{"first_name":"J.","last_name":"Troschitz","full_name":"Troschitz, J."},{"full_name":"Gude, M.","first_name":"M.","last_name":"Gude"},{"last_name":"Brosius","first_name":"A.","full_name":"Brosius, A."}],"year":"2021","title":"A Method for Characterization of Geometric Deviations in Clinch Points with Computed Tomography and Transient Dynamic Analysis","status":"public","volume":883,"user_id":"14931","doi":"10.4028/www.scientific.net/kem.883.89","_id":"30683","language":[{"iso":"eng"}],"page":"89-96"}]