---
_id: '57971'
abstract:
- lang: eng
  text: 'Repetitive TMS (rTMS) with a frequency of 5-10~Hz is widely used for language
    mapping. However, it may be accompanied by discomfort and is limited in the number
    and reliability of evoked language errors. We, here, systematically tested the
    influence of different stimulation frequencies (i.e., 10, 30, and 50 Hz) on tolerability,
    number, reliability, and cortical distribution of language errors aiming at improved
    language mapping. 15 right-handed, healthy subjects (m~=~8, median age: 29 yrs)
    were investigated in two sessions, separated by 2-5 days. In each session, 10,
    30, and 50 Hz rTMS were applied over the left hemisphere in a randomized order
    during a picture naming task. Overall, 30 Hz rTMS evoked significantly more errors
    (20 $\pm$ 12{%}) compared to 50 Hz (12 $\pm$ 8{%}; p {\textless}.01), whereas
    error rates were comparable between 30/50 and 10~Hz (18 $\pm$ 11{%}). Across all
    conditions, a significantly higher error rate was found in Session 1 (19 $\pm$
    13{%}) compared to Session 2 (13 $\pm$ 7{%}, p {\textless}.05). The error rate
    was poorly reliable between sessions for 10 (intraclass correlation coefficient,
    ICC~=~.315) and 30 Hz (ICC~=~.427), whereas 50 Hz showed a moderate reliability
    (ICC~=~.597). Spatial reliability of language errors was low to moderate with
    a tendency toward increased reliability for higher frequencies, for example, within
    frontal regions. Compared to 10~Hz, both, 30 and 50 Hz were rated as less painful.
    Taken together, our data favor the use of rTMS-protocols employing higher frequencies
    for evoking language errors reliably and with reduced discomfort, depending on
    the region of interest.'
author:
- first_name: Charlotte
  full_name: Nettekoven, Charlotte
  last_name: Nettekoven
- first_name: Julia
  full_name: Pieczewski, Julia
  last_name: Pieczewski
- first_name: Volker
  full_name: Neuschmelting, Volker
  last_name: Neuschmelting
- first_name: Kristina
  full_name: Jonas, Kristina
  id: '94540'
  last_name: Jonas
  orcid: 0000-0002-1067-9139
- first_name: Roland
  full_name: Goldbrunner, Roland
  last_name: Goldbrunner
- first_name: Christian
  full_name: Grefkes, Christian
  last_name: Grefkes
- first_name: Carolin
  full_name: Weiss Lucas, Carolin
  last_name: Weiss Lucas
citation:
  ama: Nettekoven C, Pieczewski J, Neuschmelting V, et al. Improving the efficacy
    and reliability of rTMS language mapping by increasing the stimulation frequency.
    <i>Human brain mapping</i>. 2021;42(16):5309–5321. doi:<a href="https://doi.org/10.1002/hbm.25619">10.1002/hbm.25619</a>
  apa: Nettekoven, C., Pieczewski, J., Neuschmelting, V., Jonas, K., Goldbrunner,
    R., Grefkes, C., &#38; Weiss Lucas, C. (2021). Improving the efficacy and reliability
    of rTMS language mapping by increasing the stimulation frequency. <i>Human Brain
    Mapping</i>, <i>42</i>(16), 5309–5321. <a href="https://doi.org/10.1002/hbm.25619">https://doi.org/10.1002/hbm.25619</a>
  bibtex: '@article{Nettekoven_Pieczewski_Neuschmelting_Jonas_Goldbrunner_Grefkes_Weiss
    Lucas_2021, title={Improving the efficacy and reliability of rTMS language mapping
    by increasing the stimulation frequency}, volume={42}, DOI={<a href="https://doi.org/10.1002/hbm.25619">10.1002/hbm.25619</a>},
    number={16}, journal={Human brain mapping}, author={Nettekoven, Charlotte and
    Pieczewski, Julia and Neuschmelting, Volker and Jonas, Kristina and Goldbrunner,
    Roland and Grefkes, Christian and Weiss Lucas, Carolin}, year={2021}, pages={5309–5321}
    }'
  chicago: 'Nettekoven, Charlotte, Julia Pieczewski, Volker Neuschmelting, Kristina
    Jonas, Roland Goldbrunner, Christian Grefkes, and Carolin Weiss Lucas. “Improving
    the Efficacy and Reliability of RTMS Language Mapping by Increasing the Stimulation
    Frequency.” <i>Human Brain Mapping</i> 42, no. 16 (2021): 5309–5321. <a href="https://doi.org/10.1002/hbm.25619">https://doi.org/10.1002/hbm.25619</a>.'
  ieee: 'C. Nettekoven <i>et al.</i>, “Improving the efficacy and reliability of rTMS
    language mapping by increasing the stimulation frequency,” <i>Human brain mapping</i>,
    vol. 42, no. 16, pp. 5309–5321, 2021, doi: <a href="https://doi.org/10.1002/hbm.25619">10.1002/hbm.25619</a>.'
  mla: Nettekoven, Charlotte, et al. “Improving the Efficacy and Reliability of RTMS
    Language Mapping by Increasing the Stimulation Frequency.” <i>Human Brain Mapping</i>,
    vol. 42, no. 16, 2021, pp. 5309–5321, doi:<a href="https://doi.org/10.1002/hbm.25619">10.1002/hbm.25619</a>.
  short: C. Nettekoven, J. Pieczewski, V. Neuschmelting, K. Jonas, R. Goldbrunner,
    C. Grefkes, C. Weiss Lucas, Human Brain Mapping 42 (2021) 5309–5321.
date_created: 2025-01-06T12:11:43Z
date_updated: 2026-04-13T11:37:55Z
doi: 10.1002/hbm.25619
extern: '1'
intvolume: '        42'
issue: '16'
keyword:
- Adult
- Brain Mapping
- Cerebral Cortex/diagnostic imaging/physiology
- Female
- Humans
- Magnetic Resonance Imaging
- Male
- Pattern Recognition
- Psycholinguistics
- Reproducibility of Results
- Speech/physiology
- Transcranial Magnetic Stimulation
- Visual/physiology
- Young Adult
language:
- iso: eng
page: 5309–5321
publication: Human brain mapping
status: public
title: Improving the efficacy and reliability of rTMS language mapping by increasing
  the stimulation frequency
type: journal_article
user_id: '61071'
volume: 42
year: '2021'
...