@article{61335,
  abstract     = {{<jats:p>Amidines are a ubiquitous class of bioactive compounds found in a wide variety of natural products; thus, efficient strategies for their preparation are in great demand. Herein, a novel protocol is reported for the synthesis of amidines based on P<jats:sup>III</jats:sup>/P<jats:sup>V</jats:sup>O redox catalysis. This two‐step, one‐pot approach involves the activation of amides via P<jats:sup>III</jats:sup>/P<jats:sup>V</jats:sup>O catalyzed in situ formation of imidoyl chloride intermediates which are directly converted upon reaction with amines into the corresponding amidines. Instead of traditionally used toxic and corrosive chloride sources, hexachloroacetone (HCA) is successfully employed as a halide source. The reaction proceeds with low catalyst loading (2 mol%) in BuOAc as the solvent. Under the optimized conditions, 20 amidines are prepared in yields up to 99%. A feasible mechanism is proposed based on experimental results. The synthetic potential of this method is evaluated in the preparation of the tyrosine kinase inhibitor (TKI) Erlotinib.</jats:p>}},
  author       = {{Medvaric, Viktorija and Paradies, Jan and Werner, Thomas}},
  issn         = {{1615-4150}},
  journal      = {{Advanced Synthesis and Catalysis}},
  keywords     = {{T2, T, CSSD}},
  publisher    = {{Wiley}},
  title        = {{{Synthesis of Amidines Via P(III)/P(V)=O Redox Catalyzed In Situ Formation of Imidoyl Chlorides From Amides}}},
  doi          = {{10.1002/adsc.70059}},
  year         = {{2025}},
}

@article{62086,
  author       = {{Stefanow, Vivian and Kell, Lukas and Leduskrasta, Aiga and Eh, Marcus and Panten, Johannes and Werner, Thomas}},
  issn         = {{0022-3263}},
  journal      = {{The Journal of Organic Chemistry}},
  keywords     = {{T4, CSSD}},
  number       = {{37}},
  pages        = {{12877--12887}},
  publisher    = {{American Chemical Society (ACS)}},
  title        = {{{Straightforward Access to Terpene-Based 1,2-Diols and Their Acetals as Fragrance Ingredients}}},
  doi          = {{10.1021/acs.joc.5c00889}},
  volume       = {{90}},
  year         = {{2025}},
}

@article{61336,
  author       = {{Zhou, Rundong and Medvaric, Viktorija and Werner, Thomas and Paradies, Jan}},
  issn         = {{0002-7863}},
  journal      = {{Journal of the American Chemical Society}},
  keywords     = {{T2, CSSD}},
  publisher    = {{American Chemical Society (ACS)}},
  title        = {{{Metal-Free Reduction of Nitrous Oxide via P<sup>III</sup>/P<sup>V</sup>═O Cycling: Mechanistic Insights and Catalytic Performance}}},
  doi          = {{10.1021/jacs.5c06190}},
  year         = {{2025}},
}

@article{62090,
  abstract     = {{<jats:p>The selective <jats:italic>N</jats:italic>-formylation and <jats:italic>N</jats:italic>-methylation of amines with carbon dioxide (CO<jats:sub>2</jats:sub>) catalyzed by methyltriphenylphosphonium methylcarbonate and tuned by polymethylhydrosiloxane or trimethoxysilane as reducing agents is reported.</jats:p>}},
  author       = {{Ren, Changyue and Terazzi, Constanza and Werner, Thomas}},
  issn         = {{1463-9262}},
  journal      = {{Green Chemistry}},
  keywords     = {{T1, T2, CSSD}},
  number       = {{1}},
  pages        = {{439--447}},
  publisher    = {{Royal Society of Chemistry (RSC)}},
  title        = {{{Tuneable reduction of CO<sub>2</sub> – organocatalyzed selective formylation and methylation of amines}}},
  doi          = {{10.1039/d3gc03993e}},
  volume       = {{26}},
  year         = {{2024}},
}

@article{62091,
  author       = {{Ren, Changyue and Spannenberg, Anke and Werner, Thomas}},
  issn         = {{2168-0485}},
  journal      = {{ACS Sustainable Chemistry &amp; Engineering}},
  keywords     = {{T1, T2, CSSD}},
  number       = {{29}},
  pages        = {{10969--10977}},
  publisher    = {{American Chemical Society (ACS)}},
  title        = {{{Phosphonium-Salt-Catalyzed <i>N</i>-Methylation and <i>N</i>-Formylation of Amines with CO<sub>2</sub>}}},
  doi          = {{10.1021/acssuschemeng.4c03464}},
  volume       = {{12}},
  year         = {{2024}},
}

@article{62088,
  author       = {{Tönjes, Jan and Medvarić, Viktorija and Werner, Thomas}},
  issn         = {{0022-3263}},
  journal      = {{The Journal of Organic Chemistry}},
  keywords     = {{T2, CSSD}},
  number       = {{15}},
  pages        = {{10729--10735}},
  publisher    = {{American Chemical Society (ACS)}},
  title        = {{{Synthesis of Trisubstituted Furans from Activated Alkenes by P(III)/P(V) Redox Cycling Catalysis}}},
  doi          = {{10.1021/acs.joc.4c00985}},
  volume       = {{89}},
  year         = {{2024}},
}

@article{62096,
  abstract     = {{<jats:title>Abstract</jats:title><jats:p>The biocatalytic kinetic resolution of cyclic carbonates derived from glycerol is reported. A selection of 26 esterases and lipases was tested for the asymmetric hydrolysis of the model substrate (epichlorohydrin carbonate) in aqueous medium. Among them, Pig Liver Esterase and Novozym® 435 showed the best selectivity with <jats:italic>E</jats:italic>=38 and 49, respectively. Both enzymes were employed for the conversion of 12 glycerol derivatives under optimized conditions. The resolution of halogenated carbonates afforded the unconverted enantiomer in up to &gt;99 : 1 <jats:italic>er</jats:italic>. Furthermore, Novozym® 435 was successfully recycled 10 times without significant loss of activity. Upscaling and isolation of the chiral carbonate was also demonstrated. Subsequent conversion of this chiral building block allowed the direct one‐pot synthesis of (<jats:italic>S</jats:italic>)‐Guaifenesin, (<jats:italic>S</jats:italic>)‐Mephenesin and (<jats:italic>S</jats:italic>)‐Chlorphenesin in up to 89 % yield and 94 : 6 <jats:italic>er</jats:italic>.</jats:p>}},
  author       = {{Terazzi, Constanza and Spannenberg, Anke and von Langermann, Jan and Werner, Thomas}},
  issn         = {{1867-3880}},
  journal      = {{ChemCatChem}},
  keywords     = {{T1, T4, CSSD}},
  number       = {{19}},
  publisher    = {{Wiley}},
  title        = {{{Chemoenzymatic Synthesis of Chiral Building Blocks Based on the Kinetic Resolution of Glycerol‐Derived Cyclic Carbonates}}},
  doi          = {{10.1002/cctc.202300917}},
  volume       = {{15}},
  year         = {{2023}},
}

@article{62095,
  author       = {{Tönjes, Jan and Kell, Lukas and Werner, Thomas}},
  issn         = {{1523-7060}},
  journal      = {{Organic Letters}},
  keywords     = {{T2, CSSD}},
  number       = {{51}},
  pages        = {{9114--9118}},
  publisher    = {{American Chemical Society (ACS)}},
  title        = {{{Organocatalytic Stereospecific Appel Reaction}}},
  doi          = {{10.1021/acs.orglett.3c03463}},
  volume       = {{25}},
  year         = {{2023}},
}

@article{37938,
  author       = {{Terazzi, Constanza and Laatz, Karoline and von Langermann, Jan and Werner, Thomas}},
  issn         = {{2168-0485}},
  journal      = {{ACS Sustainable Chemistry and Engineering}},
  keywords     = {{T1, T3, CSSD}},
  number       = {{40}},
  pages        = {{13335--13342}},
  publisher    = {{American Chemical Society (ACS)}},
  title        = {{{Synthesis of Cyclic Carbonates Catalyzed by CaI<sub>2</sub>–Et<sub>3</sub>N and Studies on Their Biocatalytic Kinetic Resolution}}},
  doi          = {{10.1021/acssuschemeng.2c03210}},
  volume       = {{10}},
  year         = {{2022}},
}

@article{37940,
  author       = {{Ren, Changyue and Spannenberg, Anke and Werner, Thomas}},
  issn         = {{2193-5807}},
  journal      = {{Asian Journal of Organic Chemistry}},
  keywords     = {{T1, T2, CSSD}},
  number       = {{9}},
  publisher    = {{Wiley}},
  title        = {{{Synthesis of Bifunctional Phosphonium Salts Bearing Perfluorinated Side Chains and Their Application in the Synthesis of Cyclic Carbonates from Epoxides and CO            <sub>2</sub>}}},
  doi          = {{10.1002/ajoc.202200156}},
  volume       = {{11}},
  year         = {{2022}},
}

@article{37946,
  abstract     = {{<jats:title>Abstract</jats:title><jats:p>The facile synthesis of highly functionalized building blocks with potential biological activity is of great interest to medicinal chemistry. The benzoxepinone core structures commonly exhibit biological activity. Thus, a short and efficient synthetic route towards benzoxepine containing scaffold, which enables late stage modification was developed. Namely, base-free catalytic Wittig reactions enabled the synthesis of bromobenzoxepinones from readily available starting materials. Subsequent, Suzuki–Miyaura and Stille reactions proved to be suitable methods to access a variety of benzoxepinone diaryl derivatives by late stage modification in only three steps. This three-step reaction sequence is suitable for high throughput applications and gives facile access to highly complex molecular structures, which are suitable for further functionalization. The antiproliferative properties of selected arylbenzoxepinones­ were tested in vitro on monolayer tumor cell line A549. Notably, in this initial screening, these compounds were found to be active in the micromolar range.</jats:p>}},
  author       = {{Werner, Thomas and Grandane, Aiga and Pudnika, Linda and Domraceva, Ilona and Zalubovskis, Raivis}},
  issn         = {{0039-7881}},
  journal      = {{Synthesis}},
  keywords     = {{T2, T4, CSSD}},
  number       = {{19}},
  pages        = {{3545--3554}},
  publisher    = {{Georg Thieme Verlag KG}},
  title        = {{{Base-Free Catalytic Wittig-/Cross-Coupling Reaction Sequence as Short Synthetic Strategy for the Preparation of Highly Functionalized Arylbenzoxepinones}}},
  doi          = {{10.1055/a-1509-6078}},
  volume       = {{53}},
  year         = {{2021}},
}

@article{37944,
  abstract     = {{<p>A Mn–PNP complex proved to be a suitable catalyst for the transfer hydrogenation of amides, carbamates, urea derivatives and even polyurethanes.</p>}},
  author       = {{Liu, Xin and Werner, Thomas}},
  issn         = {{2041-6520}},
  journal      = {{Chemical Science}},
  keywords     = {{T1, T3, CSSD}},
  number       = {{31}},
  pages        = {{10590--10597}},
  publisher    = {{Royal Society of Chemistry (RSC)}},
  title        = {{{Indirect reduction of CO<sub>2</sub> and recycling of polymers by manganese-catalyzed transfer hydrogenation of amides, carbamates, urea derivatives, and polyurethanes}}},
  doi          = {{10.1039/d1sc02663a}},
  volume       = {{12}},
  year         = {{2021}},
}

@article{37945,
  abstract     = {{<p>PMHS proved to be a suitable terminal reductant for P(<sc>iii</sc>)/P(<sc>v</sc>) redox cycling with a methyl-substituted phosphetane as catalyst and BuOAc as solvent. The formation of water by silanol condensation was identified as main pathway of siloxane formation.</p>}},
  author       = {{Tönjes, Jan and Longwitz, Lars and Werner, Thomas}},
  issn         = {{1463-9262}},
  journal      = {{Green Chemistry}},
  keywords     = {{T2, CSSD}},
  number       = {{13}},
  pages        = {{4852--4857}},
  publisher    = {{Royal Society of Chemistry (RSC)}},
  title        = {{{Poly(methylhydrosiloxane) as a reductant in the catalytic base-free Wittig reaction}}},
  doi          = {{10.1039/d1gc00953b}},
  volume       = {{23}},
  year         = {{2021}},
}

@article{62098,
  author       = {{Stefanow, Vivian and Grandane, Aiga and Eh, Marcus and Panten, Johannes and Spannenberg, Anke and Werner, Thomas}},
  issn         = {{1083-6160}},
  journal      = {{Organic Process Research &amp; Development}},
  keywords     = {{T4, CSSD}},
  number       = {{1}},
  pages        = {{89--97}},
  publisher    = {{American Chemical Society (ACS)}},
  title        = {{{Stereoselective Synthesis of a<i>cis</i>-Cedrane-8,9-diol as a Key Intermediate for an Amber Odorant}}},
  doi          = {{10.1021/acs.oprd.0c00423}},
  volume       = {{25}},
  year         = {{2021}},
}

@article{62099,
  author       = {{Stefanow, Vivian and Grandane, Aiga and Eh, Marcus and Panten, Johannes and Spannenberg, Anke and Werner, Thomas}},
  issn         = {{1083-6160}},
  journal      = {{Organic Process Research &amp; Development}},
  keywords     = {{T4, CSSD}},
  number       = {{1}},
  pages        = {{89--97}},
  publisher    = {{American Chemical Society (ACS)}},
  title        = {{{Stereoselective Synthesis of a<i>cis</i>-Cedrane-8,9-diol as a Key Intermediate for an Amber Odorant}}},
  doi          = {{10.1021/acs.oprd.0c00423}},
  volume       = {{25}},
  year         = {{2021}},
}

@article{37943,
  author       = {{Wirth, Marisa A. and Longwitz, Lars and Kanwischer, Marion and Gros, Peter and Leinweber, Peter and Werner, Thomas}},
  issn         = {{0147-6513}},
  journal      = {{Ecotoxicology and Environmental Safety}},
  keywords     = {{T4, CSSD}},
  publisher    = {{Elsevier BV}},
  title        = {{{AMPA-15N – Synthesis and application as standard compound in traceable degradation studies of glyphosate}}},
  doi          = {{10.1016/j.ecoenv.2021.112768}},
  volume       = {{225}},
  year         = {{2021}},
}

@article{37948,
  author       = {{Liu, Xin and Werner, Thomas}},
  issn         = {{1615-4150}},
  journal      = {{Advanced Synthesis and Catalysis}},
  keywords     = {{T1, T3, CSSD}},
  number       = {{4}},
  pages        = {{1096--1104}},
  publisher    = {{Wiley}},
  title        = {{{Selective Construction of C−C and C=C Bonds by Manganese Catalyzed Coupling of Alcohols with Phosphorus Ylides}}},
  doi          = {{10.1002/adsc.202001209}},
  volume       = {{363}},
  year         = {{2021}},
}

@article{62102,
  abstract     = {{<jats:title>Abstract</jats:title><jats:p>The carbon–carbon double bond of unsaturated carbonyl compounds was readily reduced by using a phosphetane oxide catalyst in the presence of a simple organosilane as the terminal reductant and water as the hydrogen source. Quantitative hydrogenation was observed when 1.0 mol % of a methyl‐substituted phosphetane oxide was employed as the catalyst. The procedure is highly selective towards activated double bonds, tolerating a variety of functional groups that are usually prone to reduction. In total, 25 alkenes and two alkynes were hydrogenated to the corresponding alkanes in excellent yields of up to 99 %. Notably, less active poly(methylhydrosiloxane) could also be utilized as the terminal reductant. Mechanistic investigations revealed the phosphane as the catalyst resting state and a protonation/deprotonation sequence as the crucial step in the catalytic cycle.</jats:p>}},
  author       = {{Longwitz, Lars and Werner, Thomas}},
  issn         = {{1433-7851}},
  journal      = {{Angewandte Chemie International Edition}},
  keywords     = {{T2, T4, CSSD}},
  number       = {{7}},
  pages        = {{2760--2763}},
  publisher    = {{Wiley}},
  title        = {{{Reduction of Activated Alkenes by P<sup>III</sup>/P<sup>V</sup> Redox Cycling Catalysis}}},
  doi          = {{10.1002/anie.201912991}},
  volume       = {{59}},
  year         = {{2020}},
}

@article{37951,
  author       = {{Liu, Xin and Longwitz, Lars and Spiegelberg, Brian and Tönjes, Jan and Beweries, Torsten and Werner, Thomas}},
  issn         = {{2155-5435}},
  journal      = {{ACS Catalysis}},
  keywords     = {{T3, CSSD}},
  number       = {{22}},
  pages        = {{13659--13667}},
  publisher    = {{American Chemical Society (ACS)}},
  title        = {{{Erbium-Catalyzed Regioselective Isomerization–Cobalt-Catalyzed Transfer Hydrogenation Sequence for the Synthesis of Anti-Markovnikov Alcohols from Epoxides under Mild Conditions}}},
  doi          = {{10.1021/acscatal.0c03294}},
  volume       = {{10}},
  year         = {{2020}},
}

@article{37955,
  author       = {{Wulf, Christoph and Reckers, Matthias and Perechodjuk, Anna and Werner, Thomas}},
  issn         = {{2168-0485}},
  journal      = {{ACS Sustainable Chemistry and Engineering}},
  keywords     = {{T1, T3, CSSD}},
  number       = {{3}},
  pages        = {{1651--1658}},
  publisher    = {{American Chemical Society (ACS)}},
  title        = {{{Catalytic Systems for the Synthesis of Biscarbonates and Their Impact on the Sequential Preparation of Non-Isocyanate Polyurethanes}}},
  doi          = {{10.1021/acssuschemeng.9b06662}},
  volume       = {{8}},
  year         = {{2020}},
}