[{"date_created":"2022-09-15T09:33:08Z","type":"journal_article","keyword":["Biochemistry (medical)","Clinical Biochemistry","Endocrinology","Biochemistry","Endocrinology","Diabetes and Metabolism"],"issue":"5","publication":"The Journal of Clinical Endocrinology & Metabolism","abstract":[{"text":"Abstract\r\n \r\n Context\r\n The effects of energy-balanced bed rest on metabolic flexibility have not been thoroughly examined.\r\n \r\n \r\n Objective\r\n We investigated the effects of 21 days of bed rest, with and without whey protein supplementation, on metabolic flexibility while maintaining energy balance. We hypothesized that protein supplementation mitigates metabolic inflexibility by preventing muscle atrophy.\r\n \r\n \r\n Design and Setting\r\n Randomized crossover longitudinal study conducted at the German Aerospace Center, Cologne, Germany.\r\n \r\n \r\n Participants and Interventions\r\n Ten healthy men were randomly assigned to dietary countermeasure or isocaloric control diet during a 21-day bed rest.\r\n \r\n \r\n Outcome Measures\r\n Before and at the end of the bed rest, metabolic flexibility was assessed during a meal test. Secondary outcomes were glucose tolerance by oral glucose tolerance test, body composition by dual energy X-ray absorptiometry, ectopic fat storage by magnetic resonance imaging, and inflammation and oxidative stress markers.\r\n \r\n \r\n Results\r\n Bed rest decreased the ability to switch from fat to carbohydrate oxidation when transitioning from fasted to fed states (i.e., metabolic inflexibility), antioxidant capacity, fat-free mass (FFM), and muscle insulin sensitivity along with greater fat deposition in muscle (P < 0.05 for all). Changes in fasting insulin and inflammation were not observed. However, glucose tolerance was reduced during acute overfeeding. Protein supplementation did not prevent FFM loss and metabolic alterations.\r\n \r\n \r\n Conclusions\r\n Physical inactivity triggers metabolic inflexibility, even when energy balance is maintained. Although reduced insulin sensitivity and increased fat deposition were observed at the muscle level, systemic glucose intolerance was detected only in response to a moderately high-fat meal. This finding supports the role of physical inactivity in metabolic inflexibility and suggests that metabolic inflexibility precedes systemic glucose intolerance.\r\n ","lang":"eng"}],"extern":"1","language":[{"iso":"eng"}],"doi":"10.1210/jc.2017-02267","publication_identifier":{"issn":["0021-972X","1945-7197"]},"author":[{"first_name":"Floriane","last_name":"Rudwill","full_name":"Rudwill, Floriane"},{"first_name":"Donal","last_name":"O’Gorman","full_name":"O’Gorman, Donal"},{"full_name":"Lefai, Etienne","first_name":"Etienne","last_name":"Lefai"},{"full_name":"Chery, Isabelle","last_name":"Chery","first_name":"Isabelle"},{"first_name":"Alexandre","last_name":"Zahariev","full_name":"Zahariev, Alexandre"},{"full_name":"Normand, Sylvie","first_name":"Sylvie","last_name":"Normand"},{"last_name":"Pagano","first_name":"Allan F","full_name":"Pagano, Allan F"},{"full_name":"Chopard, Angèle","last_name":"Chopard","first_name":"Angèle"},{"last_name":"Damiot","first_name":"Anthony","full_name":"Damiot, Anthony"},{"last_name":"Laurens","first_name":"Claire","full_name":"Laurens, Claire"},{"full_name":"Hodson, Leanne","first_name":"Leanne","last_name":"Hodson"},{"last_name":"Canet-Soulas","first_name":"Emmanuelle","full_name":"Canet-Soulas, Emmanuelle"},{"last_name":"Heer","first_name":"Martina","full_name":"Heer, Martina"},{"last_name":"Meuthen","first_name":"Petra Frings","full_name":"Meuthen, Petra Frings"},{"last_name":"Bühlmeier","first_name":"Judith","full_name":"Bühlmeier, Judith","id":"89838"},{"first_name":"Natalie","last_name":"Baecker","full_name":"Baecker, Natalie"},{"full_name":"Meiller, Laure","last_name":"Meiller","first_name":"Laure"},{"full_name":"Gauquelin-Koch, Guillemette","first_name":"Guillemette","last_name":"Gauquelin-Koch"},{"full_name":"Blanc, Stéphane","last_name":"Blanc","first_name":"Stéphane"},{"full_name":"Simon, Chantal","first_name":"Chantal","last_name":"Simon"},{"last_name":"Bergouignan","first_name":"Audrey","full_name":"Bergouignan, Audrey"}],"year":"2018","title":"Metabolic Inflexibility Is an Early Marker of Bed-Rest–Induced Glucose Intolerance Even When Fat Mass Is Stable","intvolume":" 103","date_updated":"2022-09-15T09:44:47Z","publication_status":"published","citation":{"short":"F. Rudwill, D. O’Gorman, E. Lefai, I. Chery, A. Zahariev, S. Normand, A.F. Pagano, A. Chopard, A. Damiot, C. Laurens, L. Hodson, E. Canet-Soulas, M. Heer, P.F. Meuthen, J. Bühlmeier, N. Baecker, L. Meiller, G. Gauquelin-Koch, S. Blanc, C. Simon, A. Bergouignan, The Journal of Clinical Endocrinology & Metabolism 103 (2018) 1910–1920.","chicago":"Rudwill, Floriane, Donal O’Gorman, Etienne Lefai, Isabelle Chery, Alexandre Zahariev, Sylvie Normand, Allan F Pagano, et al. “Metabolic Inflexibility Is an Early Marker of Bed-Rest–Induced Glucose Intolerance Even When Fat Mass Is Stable.” The Journal of Clinical Endocrinology & Metabolism 103, no. 5 (2018): 1910–20. https://doi.org/10.1210/jc.2017-02267.","apa":"Rudwill, F., O’Gorman, D., Lefai, E., Chery, I., Zahariev, A., Normand, S., Pagano, A. F., Chopard, A., Damiot, A., Laurens, C., Hodson, L., Canet-Soulas, E., Heer, M., Meuthen, P. F., Bühlmeier, J., Baecker, N., Meiller, L., Gauquelin-Koch, G., Blanc, S., … Bergouignan, A. (2018). Metabolic Inflexibility Is an Early Marker of Bed-Rest–Induced Glucose Intolerance Even When Fat Mass Is Stable. The Journal of Clinical Endocrinology & Metabolism, 103(5), 1910–1920. https://doi.org/10.1210/jc.2017-02267","ieee":"F. Rudwill et al., “Metabolic Inflexibility Is an Early Marker of Bed-Rest–Induced Glucose Intolerance Even When Fat Mass Is Stable,” The Journal of Clinical Endocrinology & Metabolism, vol. 103, no. 5, pp. 1910–1920, 2018, doi: 10.1210/jc.2017-02267.","ama":"Rudwill F, O’Gorman D, Lefai E, et al. Metabolic Inflexibility Is an Early Marker of Bed-Rest–Induced Glucose Intolerance Even When Fat Mass Is Stable. The Journal of Clinical Endocrinology & Metabolism. 2018;103(5):1910-1920. doi:10.1210/jc.2017-02267","bibtex":"@article{Rudwill_O’Gorman_Lefai_Chery_Zahariev_Normand_Pagano_Chopard_Damiot_Laurens_et al._2018, title={Metabolic Inflexibility Is an Early Marker of Bed-Rest–Induced Glucose Intolerance Even When Fat Mass Is Stable}, volume={103}, DOI={10.1210/jc.2017-02267}, number={5}, journal={The Journal of Clinical Endocrinology & Metabolism}, publisher={The Endocrine Society}, author={Rudwill, Floriane and O’Gorman, Donal and Lefai, Etienne and Chery, Isabelle and Zahariev, Alexandre and Normand, Sylvie and Pagano, Allan F and Chopard, Angèle and Damiot, Anthony and Laurens, Claire and et al.}, year={2018}, pages={1910–1920} }","mla":"Rudwill, Floriane, et al. “Metabolic Inflexibility Is an Early Marker of Bed-Rest–Induced Glucose Intolerance Even When Fat Mass Is Stable.” The Journal of Clinical Endocrinology & Metabolism, vol. 103, no. 5, The Endocrine Society, 2018, pp. 1910–20, doi:10.1210/jc.2017-02267."},"_id":"33392","publisher":"The Endocrine Society","page":"1910-1920","volume":103,"user_id":"89838","status":"public"},{"citation":{"bibtex":"@article{Bühlmeier_Frings-Meuthen_Remer_Maser-Gluth_Stehle_Biolo_Heer_2012, title={Alkaline Salts to Counteract Bone Resorption and Protein Wasting Induced by High Salt Intake: Results of a Randomized Controlled Trial}, volume={97}, DOI={10.1210/jc.2012-2857}, number={12}, journal={The Journal of Clinical Endocrinology & Metabolism}, publisher={The Endocrine Society}, author={Bühlmeier, Judith and Frings-Meuthen, Petra and Remer, Thomas and Maser-Gluth, Christiane and Stehle, Peter and Biolo, Gianni and Heer, Martina}, year={2012}, pages={4789–4797} }","ama":"Bühlmeier J, Frings-Meuthen P, Remer T, et al. Alkaline Salts to Counteract Bone Resorption and Protein Wasting Induced by High Salt Intake: Results of a Randomized Controlled Trial. The Journal of Clinical Endocrinology & Metabolism. 2012;97(12):4789-4797. doi:10.1210/jc.2012-2857","mla":"Bühlmeier, Judith, et al. “Alkaline Salts to Counteract Bone Resorption and Protein Wasting Induced by High Salt Intake: Results of a Randomized Controlled Trial.” The Journal of Clinical Endocrinology & Metabolism, vol. 97, no. 12, The Endocrine Society, 2012, pp. 4789–97, doi:10.1210/jc.2012-2857.","chicago":"Bühlmeier, Judith, Petra Frings-Meuthen, Thomas Remer, Christiane Maser-Gluth, Peter Stehle, Gianni Biolo, and Martina Heer. “Alkaline Salts to Counteract Bone Resorption and Protein Wasting Induced by High Salt Intake: Results of a Randomized Controlled Trial.” The Journal of Clinical Endocrinology & Metabolism 97, no. 12 (2012): 4789–97. https://doi.org/10.1210/jc.2012-2857.","short":"J. Bühlmeier, P. Frings-Meuthen, T. Remer, C. Maser-Gluth, P. Stehle, G. Biolo, M. Heer, The Journal of Clinical Endocrinology & Metabolism 97 (2012) 4789–4797.","ieee":"J. Bühlmeier et al., “Alkaline Salts to Counteract Bone Resorption and Protein Wasting Induced by High Salt Intake: Results of a Randomized Controlled Trial,” The Journal of Clinical Endocrinology & Metabolism, vol. 97, no. 12, pp. 4789–4797, 2012, doi: 10.1210/jc.2012-2857.","apa":"Bühlmeier, J., Frings-Meuthen, P., Remer, T., Maser-Gluth, C., Stehle, P., Biolo, G., & Heer, M. (2012). Alkaline Salts to Counteract Bone Resorption and Protein Wasting Induced by High Salt Intake: Results of a Randomized Controlled Trial. The Journal of Clinical Endocrinology & Metabolism, 97(12), 4789–4797. https://doi.org/10.1210/jc.2012-2857"},"status":"public","user_id":"89838","volume":97,"page":"4789-4797","_id":"33399","publisher":"The Endocrine Society","extern":"1","issue":"12","publication":"The Journal of Clinical Endocrinology & Metabolism","keyword":["Biochemistry (medical)","Clinical Biochemistry","Endocrinology","Biochemistry","Endocrinology","Diabetes and Metabolism"],"type":"journal_article","date_created":"2022-09-15T09:37:07Z","date_updated":"2022-09-15T09:43:26Z","publication_status":"published","intvolume":" 97","title":"Alkaline Salts to Counteract Bone Resorption and Protein Wasting Induced by High Salt Intake: Results of a Randomized Controlled Trial","year":"2012","publication_identifier":{"issn":["0021-972X","1945-7197"]},"author":[{"last_name":"Bühlmeier","first_name":"Judith","full_name":"Bühlmeier, Judith","id":"89838"},{"last_name":"Frings-Meuthen","first_name":"Petra","full_name":"Frings-Meuthen, Petra"},{"first_name":"Thomas","last_name":"Remer","full_name":"Remer, Thomas"},{"last_name":"Maser-Gluth","first_name":"Christiane","full_name":"Maser-Gluth, Christiane"},{"full_name":"Stehle, Peter","first_name":"Peter","last_name":"Stehle"},{"last_name":"Biolo","first_name":"Gianni","full_name":"Biolo, Gianni"},{"last_name":"Heer","first_name":"Martina","full_name":"Heer, Martina"}],"doi":"10.1210/jc.2012-2857","language":[{"iso":"eng"}]},{"citation":{"ama":"Gad MZ, Hassanein SI, Abdel-Maksoud SM, Shaban GM, Abou-Aisha K, Elgabarty H. Assessment of serum levels of asymmetric dimethylarginine, symmetric dimethylarginine and<scp>l</scp>-arginine in coronary artery disease. Biomarkers. 2010;15(8):746-752. doi:10.3109/1354750x.2010.519784","bibtex":"@article{Gad_Hassanein_Abdel-Maksoud_Shaban_Abou-Aisha_Elgabarty_2010, title={Assessment of serum levels of asymmetric dimethylarginine, symmetric dimethylarginine and<scp>l</scp>-arginine in coronary artery disease}, volume={15}, DOI={10.3109/1354750x.2010.519784}, number={8}, journal={Biomarkers}, publisher={Informa UK Limited}, author={Gad, Mohamed Z. and Hassanein, Sally I. and Abdel-Maksoud, Sahar M. and Shaban, Gamal M. and Abou-Aisha, Khaled and Elgabarty, Hossam}, year={2010}, pages={746–752} }","mla":"Gad, Mohamed Z., et al. “Assessment of Serum Levels of Asymmetric Dimethylarginine, Symmetric Dimethylarginine And<scp>l</Scp>-Arginine in Coronary Artery Disease.” Biomarkers, vol. 15, no. 8, Informa UK Limited, 2010, pp. 746–52, doi:10.3109/1354750x.2010.519784.","chicago":"Gad, Mohamed Z., Sally I. Hassanein, Sahar M. Abdel-Maksoud, Gamal M. Shaban, Khaled Abou-Aisha, and Hossam Elgabarty. “Assessment of Serum Levels of Asymmetric Dimethylarginine, Symmetric Dimethylarginine And<scp>l</Scp>-Arginine in Coronary Artery Disease.” Biomarkers 15, no. 8 (2010): 746–52. https://doi.org/10.3109/1354750x.2010.519784.","short":"M.Z. Gad, S.I. Hassanein, S.M. Abdel-Maksoud, G.M. Shaban, K. Abou-Aisha, H. Elgabarty, Biomarkers 15 (2010) 746–752.","apa":"Gad, M. Z., Hassanein, S. I., Abdel-Maksoud, S. M., Shaban, G. M., Abou-Aisha, K., & Elgabarty, H. (2010). Assessment of serum levels of asymmetric dimethylarginine, symmetric dimethylarginine and<scp>l</scp>-arginine in coronary artery disease. Biomarkers, 15(8), 746–752. https://doi.org/10.3109/1354750x.2010.519784","ieee":"M. Z. Gad, S. I. Hassanein, S. M. Abdel-Maksoud, G. M. Shaban, K. Abou-Aisha, and H. Elgabarty, “Assessment of serum levels of asymmetric dimethylarginine, symmetric dimethylarginine and<scp>l</scp>-arginine in coronary artery disease,” Biomarkers, vol. 15, no. 8, pp. 746–752, 2010, doi: 10.3109/1354750x.2010.519784."},"status":"public","_id":"34315","publisher":"Informa UK Limited","page":"746-752","volume":15,"user_id":"60250","publication":"Biomarkers","issue":"8","date_created":"2022-12-09T12:17:07Z","type":"journal_article","keyword":["Health","Toxicology and Mutagenesis","Clinical Biochemistry","Biochemistry"],"author":[{"first_name":"Mohamed Z.","last_name":"Gad","full_name":"Gad, Mohamed Z."},{"last_name":"Hassanein","first_name":"Sally I.","full_name":"Hassanein, Sally I."},{"full_name":"Abdel-Maksoud, Sahar M.","last_name":"Abdel-Maksoud","first_name":"Sahar M."},{"first_name":"Gamal M.","last_name":"Shaban","full_name":"Shaban, Gamal M."},{"first_name":"Khaled","last_name":"Abou-Aisha","full_name":"Abou-Aisha, Khaled"},{"id":"60250","orcid":"0000-0002-4945-1481","first_name":"Hossam","last_name":"Elgabarty","full_name":"Elgabarty, Hossam"}],"publication_identifier":{"issn":["1354-750X","1366-5804"]},"title":"Assessment of serum levels of asymmetric dimethylarginine, symmetric dimethylarginine andl-arginine in coronary artery disease","year":"2010","intvolume":" 15","date_updated":"2022-12-09T12:17:22Z","publication_status":"published","language":[{"iso":"eng"}],"doi":"10.3109/1354750x.2010.519784"}]