@article{52713,
abstract = {{ABSTRACT
OBJECTIVE:
The aim of this analysis was to investigate whether habitual intake of total dairy (TD) or different dairy types (liquid, solid, fermented, not-fermented, low-fat, high-fat, low-sugar and high-sugar dairy) during adolescence is associated with biomarkers of low-grade inflammation as well as risk factors of type 2 diabetes in young adulthood.
DESIGN:
Multivariable linear regression analyses were used to investigate prospective associations between estimated TD intake as well as intake of different types of dairy and a pro-inflammatory score, based on hsCRP, IL-6, IL-18, leptin and adiponectin, and insulin resistance assessed as HOMA2-IR in an open cohort study.
SETTING:
Dortmund, Germany
PARTICIPANTS:
Data from participants (n=375) of the DOrtmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study were included, for whom at least two 3-day weighed dietary records during adolescence (median age: 11 years) and one blood sample in young adulthood (>18 years) were available.
RESULTS:
There was no statistically significant association between TD intake or intake of any dairy type and the pro-inflammatory score (all p>0.05). TD intake as well as each dairy type intake and insulin resistance also showed no association (all p>0.05).
CONCLUSIONS:
The habitual intake of dairy or individual types of dairy during adolescence does not seem to have a major impact on low-grade systemic inflammation and insulin resistance in the long term. There was no indication regarding a restriction of dairy intake for healthy children and adolescents in terms of diabetes risk reduction.
}},
author = {{Hohoff, E and Jankovic, N and Perrar, I and Schnermann, ME and Herder, C and Nöthlings, U and Libuda, Lars and Alexy, U}},
issn = {{1368-9800}},
journal = {{Public Health Nutrition}},
keywords = {{Public Health, Environmental and Occupational Health, Nutrition and Dietetics, Medicine (miscellaneous)}},
pages = {{1--26}},
publisher = {{Cambridge University Press (CUP)}},
title = {{{The association between dairy intake in adolescents with inflammation and risk markers of type 2 diabetes during young adulthood – results of the DONALD study}}},
doi = {{10.1017/s1368980024000624}},
year = {{2024}},
}
@article{48486,
abstract = {{AbstractIntroductionIn Europe, most Internet searches for school‐related tasks are situated at home, where parents can support adolescents. Although the frequency (quantity) of parental support has already been analyzed, a research gap exists concerning the quality of parental support in adolescents' information‐related Internet use. The quality of parental support in the field of homework involvement is known to be a predictor of adolescents' learning motivation and academic achievement, often discussed with regard to self‐determination theory (SDT) in terms of autonomy support, structure, emotional support, and control. These categories were adapted in this study to analyze parents' support in adolescents' Internet searching activities.MethodsUsing a mixed‐methods approach, we combined quantitative questionnaires and qualitative observations to analyze joint information‐related Internet uses. Therefore, 243 parent–adolescent dyads were surveyed and six parent–adolescent dyads were observed by videography in 2019/2020 in Germany. The adolescents were 11 years old, on average.ResultsThe parents rated all qualities higher than the adolescents. Emotional support was rated highest by both groups, whereas structure was rated lowest. Adolescents' and parents' view on parental support differ. The qualitative study revealed parents' often interfering behavior, whereas emotional support was low. Further, the active role of adolescents was highlighted in both quantitative and qualitative data.ConclusionsBy combining quantitative and qualitative approaches, we demonstrated a fruitful application of SDT in analyzing the quality of parental support during adolescents' Internet searches at home and shed light on the co‐construction of joint Internet searches.}},
author = {{Kurock, Ricarda and Teichert, Jeannine and Meister, Dorothee M. and Gerhardts, Lara and Buhl, Heike M. and Bonanati, Sabrina}},
issn = {{0140-1971}},
journal = {{Journal of Adolescence}},
keywords = {{Psychiatry and Mental health, Developmental and Educational Psychology, Social Psychology, Pediatrics, Perinatology and Child Health}},
number = {{3}},
pages = {{566--579}},
publisher = {{Wiley}},
title = {{{A mixed‐methods study of the quality of parental support during adolescents' information‐related Internet use as a co‐construction process}}},
doi = {{http://dx.doi.org/10.1002/jad.12264}},
volume = {{96}},
year = {{2024}},
}
@inproceedings{45270,
abstract = {{Clinical depression is a serious mental disorder that poses challenges for both personal and public health. Millions of people struggle with depression each year, but for many, the disorder goes undiagnosed or untreated. Over the last decade, early depression detection on social media emerged as an interdisciplinary research field. However, there is still a gap in detecting hesitant, depression-susceptible individuals with minimal direct depressive signals at an early stage. We, therefore, take up this open point and leverage posts from Reddit to fill the addressed gap. Our results demonstrate the potential of contemporary Transformer architectures in yielding promising predictive capabilities for mental health research. Furthermore, we investigate the model’s interpretability using a surrogate and a topic modeling approach. Based on our findings, we consider this work as a further step towards developing a better understanding of mental eHealth and hope that our results can support the development of future technologies.}},
author = {{Halimeh, Haya and Caron, Matthew and Müller, Oliver}},
booktitle = {{Hawaii International Conference on System Sciences}},
keywords = {{Social Media and Healthcare Technology, early depression detection, liwc, mental health, transfer learning, transformer architectures}},
title = {{{Early Depression Detection with Transformer Models: Analyzing the Relationship between Linguistic and Psychology-Based Features}}},
year = {{2023}},
}
@article{44591,
abstract = {{AbstractThe ability of various policy activities to reduce the reproduction rate of the COVID-19 disease is widely discussed. Using a stringency index that comprises a variety of lockdown levels, such as school and workplace closures, we analyze the effectiveness of government restrictions. At the same time, we investigate the capacity of a range of lockdown measures to lower the reproduction rate by considering vaccination rates and testing strategies. By including all three components in an SIR (Susceptible, Infected, Recovery) model, we show that a general and comprehensive test strategy is instrumental in reducing the spread of COVID-19. The empirical study demonstrates that testing and isolation represent a highly effective and preferable approach towards overcoming the pandemic, in particular until vaccination rates have risen to the point of herd immunity.}},
author = {{Fritz, Marlon and Gries, Thomas and Redlin, Margarete}},
issn = {{2199-9023}},
journal = {{International Journal of Health Economics and Management}},
keywords = {{Health Policy, Economics, Econometrics and Finance (miscellaneous)}},
publisher = {{Springer Science and Business Media LLC}},
title = {{{The effectiveness of vaccination, testing, and lockdown strategies against COVID-19}}},
doi = {{10.1007/s10754-023-09352-1}},
year = {{2023}},
}
@article{41456,
abstract = {{Abstract
Background
The German total diet study (TDS)—BfR MEAL Study—established its food list in 2016 based on food consumption data of children (0.5–<5 years) and adults (14–80 years). The list consists of 356 foods selected for analysis in order to ensure ≥90% coverage of the diet. Recently, new food consumption data for children (0.5–<6 and 6–<12 years) in Germany became available, which raised the opportunity to evaluate the applicability of the MEAL food list 2016 on new data.
Objective
We tested the hypotheses that the MEAL food list 2016 also covers ≥90% of the diet of the new collected food consumption data, and that the selection of foods from younger children and adults was sufficient to also cover the middle age group (6–<12 years). Strategies for updating the existing food list were assessed.
Methods
Three approaches evaluated the reusability and potential adjustment strategies of the existing food list. Approach 1 applied the existing food list to new food consumption data. Approach 2 allowed the extension of the existing food list to improve coverage of food consumption. Approach 3 set up a new food list based on the new data.
Results
The MEAL food list 2016 covered 94% of the overall diet of the new collected food consumption data. The diet of the middle age group was sufficiently covered with 91%. However, coverage on main food group or population subgroup level was <90% in some cases. Approach 3 most accurately identified relevant modifications to the existing food list. 94% of the MEAL food list 2016 could be re-used and 51 new foods were identified as potentially relevant.
Significance
The results suggest that a high investment in the coverage of a TDS food list will lower the effort and the resources to keep data updated in the long-term.
Impact
There is no established approach to update a TDS food list. This study provides comparative approaches to handle newly collected food consumption data for follow-on TDS activities. The results provide useful information for institutions planning or updating a TDS. Furthermore, new food consumption data for children in Germany recently became available and are here presented for the first time.
}},
author = {{Kolbaum, Anna Elena and Ptok, Sebastian and Jung, Christian and Libuda, Lars and Lindtner, Oliver}},
issn = {{1559-0631}},
journal = {{Journal of Exposure Science & Environmental Epidemiology}},
keywords = {{Public Health, Environmental and Occupational Health, Pollution, Toxicology, Epidemiology}},
publisher = {{Springer Science and Business Media LLC}},
title = {{{Reusability of Germany´s total diet study food list upon availability of new food consumption data—comparison of three update strategies}}},
doi = {{10.1038/s41370-023-00522-4}},
year = {{2023}},
}
@article{45807,
abstract = {{Abstract
Background
Occupational health interventions for leaders are underrepresented in small and medium-sized enterprises (SMEs). When creating and developing effective occupational health interventions, identification of the specific needs of the target group is regarded as an essential step before planning an intervention. Therefore, the aim of this study was (1) to examine the subjectively experienced work-related stressors of leaders in small and medium-sized IT and technological services enterprises, (2) to explore coping behaviors leaders use to deal with the experienced work-related stressors, (3) to investigate resources supporting the coping process and (4) to identify potentially self-perceived consequences resulting from the experienced stressors.
Methods
Ten semi-structured interviews with leaders in small and medium-sized IT and technological services enterprises were conducted. The interviews were transcribed and analyzed with content-structuring qualitative content analysis in accordance to Kuckartz.
Results
Leaders in small and medium-sized IT and technological services enterprises experience various stressors caused by work organization as well as industry-related stressors and other work-related stressors. To address the experienced stressors, leaders apply problem focused coping behaviors (e.g. performing changes on structural and personal level), emotional focused coping behaviors (e.g. balancing activities, cognitive restructuring) as well as the utilization of social support. Helpful resources for the coping process include organizational, social and personal resources. As a result of the experienced work-related stressors, interviewees stated to experience different health impairments, negative effects on work quality as well as neglect of leisure activities and lack of time for family and friends.
Conclusion
The identified experienced work-related stressors, applied coping behaviors, utilized resources and emerging consequences underpin the urgent need for the development and performance of health-oriented leadership interventions for leaders in small and medium- sized IT and technological services. The results of this study can be used when designing a target-oriented intervention for the examined target group.
}},
author = {{Dannheim, Indra and Buyken, Anette and Kroke, Anja}},
issn = {{1471-2458}},
journal = {{BMC Public Health}},
keywords = {{Public Health, Environmental and Occupational Health}},
number = {{1}},
publisher = {{Springer Science and Business Media LLC}},
title = {{{Work-related stressors and coping behaviors among leaders in small and medium-sized IT and technological services enterprises}}},
doi = {{10.1186/s12889-023-15581-3}},
volume = {{23}},
year = {{2023}},
}
@article{45806,
abstract = {{Abstract
Objective:
To systematically review the impact of choice architecture interventions (CAI) on the food choice of healthy adolescents in a secondary school setting. Factors potentially contributing to the effectiveness of CAI types and numbers implemented and its long-term success were examined.
Design:
PUBMED and Web of Science were systematically searched in October 2021. Publications were included following predefined inclusion criteria and grouped according to number and duration of implemented interventions. Intervention impact was determined by systematic description of the reported quantitative changes in food choice and/or consumption. Intervention types were compared with regards to food selection and sustained effects either during or following the intervention.
Setting:
CAI on food choice of healthy adolescents in secondary schools.
Participants:
Not applicable
Results:
Fourteen studies were included; four randomized controlled trials and five each of controlled or uncontrolled pre-post design, respectively. Four studies implemented a single CAI type, with ten implementing > 1. Three studies investigated CAI effects over the course of a school year either by continuous or repeated data collection, while ten studies’ schools were visited on selected days during intervention. Twelve studies reported desired changes in overall food selection, yet effects were not always significant, and appeared less conclusive for longer term studies.
Conclusions:
This review found promising evidence that CAI can be effective in encouraging favorable food choices in healthy adolescents in a secondary school setting. However, further studies designed to evaluate complex interventions are needed.
}},
author = {{Schulte, Eva A. and Winkler, Gertrud and Brombach, Christine and Buyken, Anette}},
issn = {{1368-9800}},
journal = {{Public Health Nutrition}},
keywords = {{Public Health, Environmental and Occupational Health, Nutrition and Dietetics, Medicine (miscellaneous)}},
pages = {{1--23}},
publisher = {{Cambridge University Press (CUP)}},
title = {{{Choice architecture interventions promoting sustained healthier food choice and consumption by students in a secondary school setting: A systematic review of intervention studies}}},
doi = {{10.1017/s1368980023001118}},
year = {{2023}},
}
@article{45981,
abstract = {{Jede Schwangerschaft bringt physische, psychische und soziale Veränderungen mit sich. Diese können zu Stress und ambivalenten Gefühlen bei Schwangeren führen, die einen starken Einfluss auf das Wohlbefinden und die Gesundheit von Mutter und Kind haben. Zur Förderung eines komplikationslosen Verlaufs der Schwangerschaft wird in der Forschungsliteratur die Stärkung der gesundheitlichen Ressourcen gefordert. Das Zürcher Ressourcen Modell (ZRM) ist ein ressourcenaktivierendes Selbstmanagementtraining, welches nach aktuellen Studienergebnissen die Gefühlsregulierung unterstützen und Stress reduzieren kann. Ziel dieser Studie war die erstmalige Wirksamkeitsprüfung des ZRM in der Schwangerschaft. Angenommen wurde, dass durch die Aktivierung der persönlichen Ressourcen der Schwangeren das Stresserleben reduziert und das subjektive Wohlbefinden gesteigert werden kann. Die Konstrukte „Stress“ und „Wohlbefinden“ wurden anhand von fünf psychometrischen Parametern operationalisiert. Durchgeführt wurde eine quasiexperimentelle unkontrollierte 6‑stündige Online-Interventionsstudie mit dem ZRM im Januar 2021 an N = 32 Schwangeren, basierend auf einem Prä-Post-Follow-up-Design. Zur Überprüfung der gebildeten Hypothesen wurden einfaktorielle Varianzanalysen (rmANOVAs) durchgeführt.
Die 1-faktoriellen rmANOVAs ergaben, dass die ZRM-Intervention das Stresserleben allgemein und schwangerschaftsspezifisch sowie das Angsterleben signifikant senken konnte. Handlungsorientierung nach Misserfolg und emotionales Wohlbefinden konnten signifikant gesteigert werden. Hinsichtlich der subjektiven Vitalität ließ sich lediglich deskriptiv eine Steigerung der Werte verzeichnen.
Die ZRM-Intervention erwies sich als wirksame Methode zur Optimierung der Stressbewältigung und Steigerung des Wohlbefindens während der Schwangerschaft. Es kann zielführend sein, das ZRM-Training als Ergänzung zur üblichen Geburtsvorbereitung einzusetzen. Zukünftige Forschungsarbeiten sollten v. a. die Übertragbarkeit der Ergebnisse unter Einbindung einer Kontrollgruppe sicherstellen.}},
author = {{Schneider, Tamara and Weber, Julia and Bauer, Nicola H.}},
issn = {{1861-6755}},
journal = {{Prävention und Gesundheitsförderung}},
keywords = {{Public Health, Environmental and Occupational Health}},
publisher = {{Springer Science and Business Media LLC}},
title = {{{„Löwenstark in der Schwangerschaft!“ Ressourcenaktivierung und Stressreduktion mit dem Zürcher Ressourcen Modell (ZRM®) – eine unkontrollierte Interventionsstudie }}},
doi = {{10.1007/s11553-023-01058-z}},
year = {{2023}},
}
@techreport{46534,
abstract = {{We study the effect of education on health (hospital stays, number of diagnosed conditions, self-rated poor health, and obesity) over the life-cycle in Germany, using compulsory schooling reforms as a source of exogenous variation. Our results suggest a positive correlation of health and education which increases over the life-cycle. We do not, however, find any positive local average treatment effects of an additional year of schooling on health or health care utilization for individuals up to age 79. An exception is obesity, where positive effects of schooling start to be visible around age 60 and become very large in age group 75-79. The results in age group 75-79 need to be interpreted with caution, however, due to small sample size and possible problems of attrition.}},
author = {{Schmitz, Hendrik and Tawiah, Beatrice Baaba}},
keywords = {{Education, health, life-cycle effects, compulsory schooling}},
publisher = {{RWI - Leibniz-Institut für Wirtschaftsforschung, Ruhr-University Bochum, TU Dortmund University, University of Duisburg-Essen}},
title = {{{Life-cycle health effects of compulsory schooling}}},
volume = {{1006}},
year = {{2023}},
}
@article{43061,
abstract = {{Purpose: The aim of this study was to examine whether cortical activity changes during exercise with increasing cognitive demands in preadolescent children. Method: Twenty healthy children (8.75 [0.91] y) performed one movement game, which was conducted with lower and higher cognitive demands. During a baseline measurement and both exercise conditions, cortical activity was recorded using a 64-channel electroencephalographic system, and heart rate was assessed. Ratings of perceived excertion and perceived cognitive engagement were examined after each condition. To analyze power spectral density in the theta, alpha-1, and alpha-2 frequency bands, an adaptive mixture independent component analysis was used to determine the spatiotemporal sources of cortical activity, and brain components were clustered to identify spatial clusters. Results: One-way repeated-measures analyses of variance revealed significant main effects for condition on theta in the prefrontal cluster, on alpha-1 in the prefrontal, central, bilateral motor, bilateral parieto-occipital, and occipital clusters, and on alpha-2 in the left motor, central, and left parieto-occipital clusters. Compared with the lower cognitive demand exercise, cortical activity was significantly higher in theta power in the prefrontal cluster and in alpha-1 power in the occipital cluster during the higher cognitive demand exercise. Conclusion: The present study shows that exercise complexity seems to influence cortical processing as it increased with increasing cognitive demands.}},
author = {{Becker, Linda and Büchel, Daniel and Lehmann, Tim and Kehne, Miriam and Baumeister, Jochen}},
issn = {{0899-8493}},
journal = {{Pediatric Exercise Science}},
keywords = {{Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine, Pediatrics, Perinatology and Child Health}},
pages = {{1--11}},
publisher = {{Human Kinetics}},
title = {{{Mobile Electroencephalography Reveals Differences in Cortical Processing During Exercises With Lower and Higher Cognitive Demands in Preadolescent Children}}},
doi = {{10.1123/pes.2021-0212}},
year = {{2023}},
}
@article{45824,
abstract = {{As cognitive function is critical for muscle coordination, cognitive training may also improve neuromuscular control strategy and knee function following an anterior cruciate ligament reconstruction (ACLR). The purpose of this case-control study was to examine the effects of cognitive training on joint stiffness regulation in response to negative visual stimuli and knee function following ACLR. A total of 20 ACLR patients and 20 healthy controls received four weeks of online cognitive training. Executive function, joint stiffness in response to emotionally evocative visual stimuli (neutral, fearful, knee injury related), and knee function outcomes before and after the intervention were compared. Both groups improved executive function following the intervention (p = 0.005). The ACLR group had greater mid-range stiffness in response to fearful (p = 0.024) and injury-related pictures (p = 0.017) than neutral contents before the intervention, while no post-intervention stiffness differences were observed among picture types. The ACLR group showed better single-legged hop for distance after cognitive training (p = 0.047), while the healthy group demonstrated no improvement. Cognitive training enhanced executive function, which may reduce joint stiffness dysregulation in response to emotionally arousing images and improve knee function in ACLR patients, presumably by facilitating neural processing necessary for neuromuscular control.}},
author = {{An, Yong Woo and Kim, Kyung-Min and DiTrani Lobacz, Andrea and Baumeister, Jochen and Higginson, Jill S. and Rosen, Jeffrey and Swanik, Charles Buz}},
issn = {{2227-9032}},
journal = {{Healthcare}},
keywords = {{Health Information Management, Health Informatics, Health Policy, Leadership and Management}},
number = {{13}},
publisher = {{MDPI AG}},
title = {{{Cognitive Training Improves Joint Stiffness Regulation and Function in ACLR Patients Compared to Healthy Controls}}},
doi = {{10.3390/healthcare11131875}},
volume = {{11}},
year = {{2023}},
}
@article{33382,
author = {{Hirtz, Raphael and Libuda, Lars and Hinney, Anke and Föcker, Manuel and Bühlmeier, Judith and Holterhus, Paul-Martin and Kulle, Alexandra and Kiewert, Cordula and Kuhnert, Ronny and Cohrdes, Caroline and Peters, Triinu and Hebebrand, Johannes and Grasemann, Corinna}},
issn = {{0165-0327}},
journal = {{Journal of Affective Disorders}},
keywords = {{Psychiatry and Mental health, Clinical Psychology}},
pages = {{103--112}},
publisher = {{Elsevier BV}},
title = {{{Age at menarche relates to depression in adolescent girls: Comparing a clinical sample to the general pediatric population}}},
doi = {{10.1016/j.jad.2022.08.092}},
volume = {{318}},
year = {{2022}},
}
@article{33692,
abstract = {{Abstract
An individual’s relation to time may be an important driver of pro-environmental behaviour. We studied whether young individual’s gender and time-orientation are associated with pro-environmental behaviour. In a controlled laboratory environment with students in Germany, participants earned money by performing a real-effort task and were then offered the opportunity to invest their money into an environmental project that supports climate protection. Afterwards, we controlled for their time-orientation. In this consequential behavioural setting, we find that males who scored higher on future-negative orientation showed significantly more pro-environmental behaviour compared to females who scored higher on future-negative orientation and males who scored lower on future-negative orientation. Interestingly, our results are completely reversed when it comes to past-positive orientation. These findings have practical implications regarding the most appropriate way to address individuals in order to achieve more pro-environmental behaviour.}},
author = {{Hoffmann, Christin and Hoppe, Julia Amelie and Ziemann, Niklas}},
issn = {{1748-9326}},
journal = {{Environmental Research Letters}},
keywords = {{Public Health, Environmental and Occupational Health, General Environmental Science, Renewable Energy, Sustainability and the Environment}},
number = {{10}},
publisher = {{IOP Publishing}},
title = {{{Who has the future in mind? Gender, time perspectives, and pro-environmental behaviour}}},
doi = {{10.1088/1748-9326/ac9296}},
volume = {{17}},
year = {{2022}},
}
@article{32326,
abstract = {{AbstractGenetic factors are relevant for both eating disorders and body weight regulation. A recent genome-wide association study (GWAS) for anorexia nervosa (AN) detected eight genome-wide significant chromosomal loci. One of these loci, rs10747478, was also genome-wide and significantly associated with body mass index (BMI). The nearest coding gene is the Polypyrimidine Tract Binding Protein 2 gene (PTBP2). To detect mutations in PTBP2, Sanger sequencing of the coding region was performed in 192 female patients with AN (acute or recovered) and 191 children or adolescents with (extreme) obesity. Twenty-five variants were identified. Twenty-three of these were predicted to be pathogenic or functionally relevant in at least one in silico tool. Two novel synonymous variants (p.Ala77Ala and p.Asp195Asp), one intronic SNP (rs188987764), and the intronic deletion (rs561340981) located in the highly conserved region of PTBP2 may have functional consequences. Ten of 20 genes interacting with PTBP2 were studied for their impact on body weight regulation based on either previous functional studies or GWAS hits for body weight or BMI. In a GWAS for BMI (Pulit et al. 2018), the number of genome-wide significant associations at the PTBP2 locus was different between males (60 variants) and females (two variants, one of these also significant in males). More than 65% of these 61 variants showed differences in the effect size pertaining to BMI between sexes (absolute value of Z-score >2, two-sided p < 0.05). One LD block overlapping 5′UTR and all coding regions of PTBP2 comprises 56 significant variants in males. The analysis based on sex-stratified BMI GWAS summary statistics implies that PTBP2 may have a more pronounced effect on body weight regulation in males than in females.}},
author = {{Zheng, Yiran and Rajcsanyi, Luisa Sophie and Herpertz-Dahlmann, Beate and Seitz, Jochen and de Zwaan, Martina and Herzog, Wolfgang and Ehrlich, Stefan and Zipfel, Stephan and Giel, Katrin and Egberts, Karin and Burghardt, Roland and Föcker, Manuel and Al-Lahham, Saad and Peters, Triinu and Libuda, Lars and Antel, Jochen and Hebebrand, Johannes and Hinney, Anke}},
issn = {{2158-3188}},
journal = {{Translational Psychiatry}},
keywords = {{Biological Psychiatry, Cellular and Molecular Neuroscience, Psychiatry and Mental health}},
number = {{1}},
publisher = {{Springer Science and Business Media LLC}},
title = {{{PTBP2 – a gene with relevance for both Anorexia nervosa and body weight regulation}}},
doi = {{10.1038/s41398-022-02018-5}},
volume = {{12}},
year = {{2022}},
}
@article{33385,
abstract = {{Abstract
Background
In Sub-Saharan African countries, rapid urbanization and increasing socio-economic status are associated with a transition to decreased physical activity (PA). A more sedentary lifestyle is linked to increased body fat leading to increments in leptin levels. Since rodent and human studies in high-income countries have shown that starvation-induced hypoleptinemia triggers high PA, efforts are warranted to pursue the hypothesis that low leptin levels in lean children of low- and middle-income countries (LMIC) are also associated with high PA.
Methods
In this cross-sectional study, we assessed seven-day PA with triaxial accelerometry (ActiGraph GT3X) among 223 primary school children (9 to 12 years of age) in rural Tanzania. Moderate-to-vigorous PA (MVPA) and total accelerometer counts per day were outcome variables. Leptin was determined using enzyme linked immunosorbent assay tests from dried blood spots. Anthropometric assessments were conducted and food insecurity and socio-demographic data were gathered using semi-structured interviews.
Results
In this sample of school children in rural Tanzania, leptin concentrations (median: 0.91 ng/mL, P25: 0.55, P75: 1.69), body mass index z-scores (median: -1.35, P25: -1.93, P75: -0.82), and height-for-age-z-scores (median: -1.16, P25: -1.96, P75: -0.61) were low. In contrast, PA levels were high with a median MVPA time of 119 min/day. Linear regression confirmed that leptin levels were negatively associated with MVPA (beta: -18.1; 95%CI: -29.7; -6.5; p = 0.002) and total accelerometer counts (beta: -90,256; 95%CI: -154,146; -26,365; p = 0.006). Children residing in areas with better infrastructure had lower MVPA levels (p < 0.001) and tended to have higher leptin levels (p = 0.062) than children residing in areas only reachable via dirt roads.
Conclusion
Our cross-sectional field study is the first that supports the hypothesis of low leptin levels as a potential endocrine trigger of high PA in lean children of a LMIC. We observed early signs of a PA transition towards a less active lifestyle in a subgroup residing in areas with better infrastructure that concomitantly tended to have higher leptin concentrations. Considering that area-dependent PA differences were more pronounced among girls than boys, whereas differences in leptin levels were less pronounced, not only biological, but also external factors explain PA transition.
}},
author = {{Ludwig, Christine and Knoll-Pientka, Nadja and Mwanri, Akwilina and Erfle, Celina and Onywera, Vincent and Tremblay, Mark S. and Bühlmeier, Judith and Luzak, Agnes and Ferland, Maike and Schulz, Holger and Libuda, Lars and Hebebrand, Johannes}},
issn = {{1471-2458}},
journal = {{BMC Public Health}},
keywords = {{Public Health, Environmental and Occupational Health}},
number = {{1}},
publisher = {{Springer Science and Business Media LLC}},
title = {{{Low leptin levels are associated with elevated physical activity among lean school children in rural Tanzania}}},
doi = {{10.1186/s12889-022-12949-9}},
volume = {{22}},
year = {{2022}},
}
@article{32327,
abstract = {{AbstractThere is preliminary evidence that adrenal steroids other than cortisol may be valuable biomarkers for major depressive disorder (MDD). So far, studies have been conducted in adults only, and conclusions are limited, mainly due to small sample sizes. Therefore, the present study assessed whether adrenal steroids serve as biomarkers for adolescent MDD. In 261 depressed adolescents (170 females) treated at a single psychiatric hospital, serum adrenal steroids (progesterone, 17-hydroxyprogesterone, 21-deoxycortisol, 11-deoxycortisol, cortisol, cortisone, deoxycorticosterone, corticosterone) were determined by liquid chromatography-tandem mass spectrometry. Findings were compared to that of an age- and sex-matched reference cohort (N = 255) by nonparametric analysis of variance. Nonparametric receiver operating characteristics (ROC) analyses were conducted to evaluate the diagnostic performance of single steroids and steroid ratios to classify depression status. Sensitivity analyses considered important confounders of adrenal functioning, and ROC results were verified by cross-validation. Compared to the reference cohort, levels of deoxycorticosterone and 21-deoxycortisol were decreased (P < 0.001). All other glucocorticoid- and mineralocorticoid-related steroids were increased (P < 0.001). The corticosterone to deoxycorticosterone ratio evidenced excellent classification characteristics, especially in females (AUC: 0.957; sensitivity: 0.902; specificity: 0.891). The adrenal steroid metabolome qualifies as a bio-readout reflecting adolescent MDD by a distinct steroid pattern that indicates dysfunction of the hypothalamus–pituitary–adrenal axis. Moreover, the corticosterone to deoxycorticosterone ratio may prospectively qualify to contribute to precision medicine in psychiatry by identifying those patients who might benefit from antiglucocorticoid treatment or those at risk for recurrence when adrenal dysfunction has not resolved.}},
author = {{Hirtz, Raphael and Libuda, Lars and Hinney, Anke and Föcker, Manuel and Bühlmeier, Judith and Holterhus, Paul-Martin and Kulle, Alexandra and Kiewert, Cordula and Hauffa, Berthold P. and Hebebrand, Johannes and Grasemann, Corinna}},
issn = {{2158-3188}},
journal = {{Translational Psychiatry}},
keywords = {{Biological Psychiatry, Cellular and Molecular Neuroscience, Psychiatry and Mental health}},
number = {{1}},
publisher = {{Springer Science and Business Media LLC}},
title = {{{The adrenal steroid profile in adolescent depression: a valuable bio-readout?}}},
doi = {{10.1038/s41398-022-01966-2}},
volume = {{12}},
year = {{2022}},
}
@article{37074,
abstract = {{Pointing is one of the first conventional means of communication and infants have various motives for engaging in it such as imperative, declarative, or informative. Little is known about the developmental paths of producing and understanding these different motives. In our longitudinal study (N = 58) during the second year of life, we experimentally elicited infants’ pointing production and comprehension in various settings and under pragmatically valid conditions. We followed two steps in our analyses and assessed the occurrence of canonical index-finger pointing for different motives and the engagement in an ongoing interaction in pursuit of a joint goal revealed by frequency and multimodal utterances. For understanding the developmental paths, we compared two groups: typically developing infants (TD) and infants who have been assessed as having delayed language development (LD). Results showed that the developmental paths differed according to the various motives. When comparing the two groups, for all motives, LD infants produced index-finger pointing 2 months later than TD infants. For the engagement, although the pattern was less consistent across settings, the frequency of pointing was comparable in both groups, but infants with LD used less canonical forms of pointing and made fewer multimodal contributions than TD children.}},
author = {{Rohlfing, Katharina J. and Lüke, Carina and Liszkowski, Ulf and Ritterfeld, Ute and Grimminger, Angela}},
issn = {{1660-4601}},
journal = {{International Journal of Environmental Research and Public Health}},
keywords = {{Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health}},
number = {{9}},
publisher = {{MDPI AG}},
title = {{{Developmental Paths of Pointing for Various Motives in Infants with and without Language Delay}}},
doi = {{10.3390/ijerph19094982}},
volume = {{19}},
year = {{2022}},
}
@article{40260,
abstract = {{BACKGROUND: Challenged by digital transformation, organizations increasingly integrate information and communication technologies into work designs. Often focal points of such digital reengineering initiatives are technical and economic aspects. Yet, as integration of new technologies affects how employee work and interact, there is a need to evaluate human-centered criteria (human-factor evaluation), optimally by involving employees as situational experts. OBJECTIVE: The present study develops an integrative and persona-based evaluation approach of human-centered criteria for application in participative digital (re-)design of work to support the joint optimization of the technical and social system. METHODS: Drawing on methods from usability evaluation, a persona-based approach is developed to facilitate comprehension and application of human-centered evaluation by employees. To that end, human-centered criteria from existing evaluation models are systemized with specific reference to digital transformation of work processes. The developed approach is tested in pilot runs of three German small and medium-sized enterprises (SMEs). RESULTS: The initial overview shows a divergence of specific human-centered criteria at the detailed level. Simultaneously, a high convergence is found for overarching dimensions and categories. The Integrative Socio-Digital Evaluation Model (ISDEM) is developed to balance complexity and abstraction of criteria. The derived persona-based approach (persISDEM) shows a good applicability in the pilot runs. CONCLUSIONS: The present study provides an amendment to existing work design approaches with an emphasis on employee participation, enabling organizations to foster employees’ comprehension and motivation to engage in evaluations of digital (re-)design of work and to create motivating and healthy jobs for successful digital transformation.}},
author = {{Schumacher, Jan-Philip and Depenbusch, Sarah and Straatmann, Tammo and Bender, Elena and Schaper, Niclas and Hamborg, Kai-Christoph}},
issn = {{1051-9815}},
journal = {{Work}},
keywords = {{Public Health, Environmental and Occupational Health, Rehabilitation}},
number = {{4}},
pages = {{1629--1654}},
publisher = {{IOS Press}},
title = {{{Participative human-factor evaluation in the context of digital work (re-)design}}},
doi = {{10.3233/wor-211248}},
volume = {{72}},
year = {{2022}},
}
@article{30117,
abstract = {{Objective: It is unclear whether and to what extent COVID-19 infection poses health risks and a chronic impairment of performance in athletes. Identification of individual health risk is an important decision-making basis for managing the pandemic risk of infection with SARS-CoV-2 in sports and return to play (RTP).Methods: This study aims 1) to analyze the longitudinal rate of seroprevalence of SARS-CoV-2 in German athletes, 2) to assess health-related consequences in athletes infected with SARS-CoV-2, and 3) to reveal effects of the COVID-19 pandemic in general and of a cleared SARS-CoV-2 infection on exercise performance. CoSmo-S is a prospective observational multicenter study establishing two cohorts: 1) athletes diagnosed positive for COVID-19 (cohort 1) and 2) federal squad athletes who perform their annual sports medical preparticipation screening (cohort 2). Comprehensive diagnostics including physical examination, laboratory blood analyses and blood biobanking, resting and exercise electrocardiogram (ECG), echocardiography, spirometry and exercise testing added by questionnaires are conducted at baseline and follow-up.Results and Conclusion: We expect that the results obtained, will allow us to formulate recommendations regarding RTP on a more evidence-based level.}},
author = {{Niess, Andreas Michael and Widmann, Manuel and Gaidai, Roman and Gölz, Christian Johannes and Schubert, Isabel and Castillo, Katty and Sachs, Jan Philipp and Bizjak, Daniel and Vollrath, Shirin and Wimbauer, Fritz and Vogel, Azin and Keller, Karsten and Burgstahler, Christof and Quermann, Anne and Kerling, Arno and Schneider, Gerald and Zacher, Jonas and Diebold, Katharina and Grummt, Maximilian and Beckendorf, Claudia and Buitenhuis, Johannes and Egger, Florian and Venhorst, Andreas and Morath, Oliver and Barsch, Friedrich and Mellwig, Klaus-Peter and Oesterschlink, Julian and Wüstenfeld, Jan and Predel, Hans-Georg and Deibert, Peter and Friedmann-Bette, Birgit and Mayer, Frank and Hirschmüller, Anja and Halle, Martin and Steinacker, Jürgen Michael and Wolfarth, Bernd and Meyer, Tim and Böttinger, Erwin and Flechtner-Mors, Marion and Bloch, Wilhelm and Haller, Bernhard and Roecker, Kai and Reinsberger, Claus}},
issn = {{1661-8564}},
journal = {{International Journal of Public Health}},
keywords = {{Public Health, Environmental and Occupational Health, Health (social science)}},
publisher = {{Frontiers Media SA}},
title = {{{COVID-19 in German Competitive Sports: Protocol for a Prospective Multicenter Cohort Study (CoSmo-S)}}},
doi = {{10.3389/ijph.2022.1604414}},
volume = {{67}},
year = {{2022}},
}
@inproceedings{58029,
author = {{Lieker, Emma and Nettekoven, Charlotte and Keil, Phillip and Louçäo, Ricardo and Jonas, Kristina and Lichtenstein, Thorsten and Picht, Thomas and Goldbrunner, Roland and Weiß-Lucas, Carolin}},
booktitle = {{73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie}},
keywords = {{Medicine and health}},
title = {{{Combining multiple tasks to identify clinically essential language tracts using fMRI-informed tractography: German Medical Science GMS Publishing House}}},
doi = {{10.3205/22DGNC076}},
year = {{2022}},
}