[{"date_updated":"2024-02-03T12:42:48Z","publisher":"Wiley","date_created":"2024-02-03T12:41:16Z","author":[{"first_name":"Jaime Andres","last_name":"Garcia-Diosa","full_name":"Garcia-Diosa, Jaime Andres"},{"first_name":"Guido","last_name":"Grundmeier","id":"194","full_name":"Grundmeier, Guido"},{"last_name":"Keller","orcid":"0000-0001-7139-3110","id":"48864","full_name":"Keller, Adrian","first_name":"Adrian"}],"title":"Effect of DNA Origami Nanostructures on Bacterial Growth","doi":"10.1002/cbic.202400091","publication_identifier":{"issn":["1439-4227","1439-7633"]},"publication_status":"published","year":"2024","citation":{"chicago":"Garcia-Diosa, Jaime Andres, Guido Grundmeier, and Adrian Keller. “Effect of DNA Origami Nanostructures on Bacterial Growth.” <i>ChemBioChem</i>, 2024. <a href=\"https://doi.org/10.1002/cbic.202400091\">https://doi.org/10.1002/cbic.202400091</a>.","ieee":"J. A. Garcia-Diosa, G. Grundmeier, and A. Keller, “Effect of DNA Origami Nanostructures on Bacterial Growth,” <i>ChemBioChem</i>, 2024, doi: <a href=\"https://doi.org/10.1002/cbic.202400091\">10.1002/cbic.202400091</a>.","apa":"Garcia-Diosa, J. A., Grundmeier, G., &#38; Keller, A. (2024). Effect of DNA Origami Nanostructures on Bacterial Growth. <i>ChemBioChem</i>. <a href=\"https://doi.org/10.1002/cbic.202400091\">https://doi.org/10.1002/cbic.202400091</a>","ama":"Garcia-Diosa JA, Grundmeier G, Keller A. Effect of DNA Origami Nanostructures on Bacterial Growth. <i>ChemBioChem</i>. Published online 2024. doi:<a href=\"https://doi.org/10.1002/cbic.202400091\">10.1002/cbic.202400091</a>","short":"J.A. Garcia-Diosa, G. Grundmeier, A. Keller, ChemBioChem (2024).","mla":"Garcia-Diosa, Jaime Andres, et al. “Effect of DNA Origami Nanostructures on Bacterial Growth.” <i>ChemBioChem</i>, Wiley, 2024, doi:<a href=\"https://doi.org/10.1002/cbic.202400091\">10.1002/cbic.202400091</a>.","bibtex":"@article{Garcia-Diosa_Grundmeier_Keller_2024, title={Effect of DNA Origami Nanostructures on Bacterial Growth}, DOI={<a href=\"https://doi.org/10.1002/cbic.202400091\">10.1002/cbic.202400091</a>}, journal={ChemBioChem}, publisher={Wiley}, author={Garcia-Diosa, Jaime Andres and Grundmeier, Guido and Keller, Adrian}, year={2024} }"},"_id":"51121","department":[{"_id":"302"}],"user_id":"48864","keyword":["Organic Chemistry","Molecular Biology","Molecular Medicine","Biochemistry"],"language":[{"iso":"eng"}],"publication":"ChemBioChem","type":"journal_article","abstract":[{"text":"<jats:p>DNA origami nanostructures are a powerful tool in biomedicine and can be used to combat drug‐resistant bacterial infections. However, the effect of unmodified DNA origami nanostructures on bacteria is yet to be elucidated. With the aim to obtain a better understanding of this phenomenon, the effect of three DNA origami shapes, i.e., DNA origami triangles, six‐helix bundles (6HBs), and 24‐helix bundles (24HBs), on the growth of Gram‐negative Escherichia coli and Gram‐positive Bacillus subtilis is investigated. These results reveal that while triangles and 24HBs can be used as a source of nutrients by E. coli and thereby promote population growth, their effect is much smaller than that of genomic single‐ and double‐stranded DNA. However, no effect on E. coli population growth is observed for the 6HBs. On the other hand, B. subtilis does not show any significant changes in population growth when cultured with the different DNA origami shapes or genomic DNA. The detailed effect of DNA origami nanostructures on bacterial growth thus depends on the competence signals and uptake mechanism of each bacterial species, as well as the DNA origami shape. This should be considered in the development of antimicrobial DNA origami nanostructures.</jats:p>","lang":"eng"}],"status":"public"},{"abstract":[{"lang":"eng","text":"<jats:p>This article presents the potential-dependent adsorption of two proteins, bovine serum albumin (BSA) and lysozyme (LYZ), on Ti6Al4V alloy at pH 7.4 and 37 °C. The adsorption process was studied on an electropolished alloy under cathodic and anodic overpotentials, compared to the open circuit potential (OCP). To analyze the adsorption process, various complementary interface analytical techniques were employed, including PM-IRRAS (polarization-modulation infrared reflection-absorption spectroscopy), AFM (atomic force microscopy), XPS (X-ray photoelectron spectroscopy), and E-QCM (electrochemical quartz crystal microbalance) measurements. The polarization experiments were conducted within a potential range where charging of the electric double layer dominates, and Faradaic currents can be disregarded. The findings highlight the significant influence of the interfacial charge distribution on the adsorption of BSA and LYZ onto the alloy surface. Furthermore, electrochemical analysis of the protein layers formed under applied overpotentials demonstrated improved corrosion protection properties. These studies provide valuable insights into protein adsorption on titanium alloys under physiological conditions, characterized by varying potentials of the passive alloy.</jats:p>"}],"status":"public","publication":"Molecules","type":"journal_article","keyword":["Chemistry (miscellaneous)","Analytical Chemistry","Organic Chemistry","Physical and Theoretical Chemistry","Molecular Medicine","Drug Discovery","Pharmaceutical Science"],"article_number":"5109","language":[{"iso":"eng"}],"_id":"46023","department":[{"_id":"321"},{"_id":"302"}],"user_id":"54863","year":"2023","intvolume":"        28","citation":{"apa":"Duderija, B., González-Orive, A., Ebbert, C., Neßlinger, V., Keller, A., &#38; Grundmeier, G. (2023). Electrode Potential-Dependent Studies of Protein Adsorption on Ti6Al4V Alloy. <i>Molecules</i>, <i>28</i>(13), Article 5109. <a href=\"https://doi.org/10.3390/molecules28135109\">https://doi.org/10.3390/molecules28135109</a>","short":"B. Duderija, A. González-Orive, C. Ebbert, V. Neßlinger, A. Keller, G. Grundmeier, Molecules 28 (2023).","mla":"Duderija, Belma, et al. “Electrode Potential-Dependent Studies of Protein Adsorption on Ti6Al4V Alloy.” <i>Molecules</i>, vol. 28, no. 13, 5109, MDPI AG, 2023, doi:<a href=\"https://doi.org/10.3390/molecules28135109\">10.3390/molecules28135109</a>.","bibtex":"@article{Duderija_González-Orive_Ebbert_Neßlinger_Keller_Grundmeier_2023, title={Electrode Potential-Dependent Studies of Protein Adsorption on Ti6Al4V Alloy}, volume={28}, DOI={<a href=\"https://doi.org/10.3390/molecules28135109\">10.3390/molecules28135109</a>}, number={135109}, journal={Molecules}, publisher={MDPI AG}, author={Duderija, Belma and González-Orive, Alejandro and Ebbert, Christoph and Neßlinger, Vanessa and Keller, Adrian and Grundmeier, Guido}, year={2023} }","ama":"Duderija B, González-Orive A, Ebbert C, Neßlinger V, Keller A, Grundmeier G. Electrode Potential-Dependent Studies of Protein Adsorption on Ti6Al4V Alloy. <i>Molecules</i>. 2023;28(13). doi:<a href=\"https://doi.org/10.3390/molecules28135109\">10.3390/molecules28135109</a>","chicago":"Duderija, Belma, Alejandro González-Orive, Christoph Ebbert, Vanessa Neßlinger, Adrian Keller, and Guido Grundmeier. “Electrode Potential-Dependent Studies of Protein Adsorption on Ti6Al4V Alloy.” <i>Molecules</i> 28, no. 13 (2023). <a href=\"https://doi.org/10.3390/molecules28135109\">https://doi.org/10.3390/molecules28135109</a>.","ieee":"B. Duderija, A. González-Orive, C. Ebbert, V. Neßlinger, A. Keller, and G. Grundmeier, “Electrode Potential-Dependent Studies of Protein Adsorption on Ti6Al4V Alloy,” <i>Molecules</i>, vol. 28, no. 13, Art. no. 5109, 2023, doi: <a href=\"https://doi.org/10.3390/molecules28135109\">10.3390/molecules28135109</a>."},"publication_identifier":{"issn":["1420-3049"]},"publication_status":"published","issue":"13","title":"Electrode Potential-Dependent Studies of Protein Adsorption on Ti6Al4V Alloy","doi":"10.3390/molecules28135109","publisher":"MDPI AG","date_updated":"2024-02-06T12:33:55Z","volume":28,"date_created":"2023-07-12T07:55:40Z","author":[{"last_name":"Duderija","full_name":"Duderija, Belma","first_name":"Belma"},{"full_name":"González-Orive, Alejandro","last_name":"González-Orive","first_name":"Alejandro"},{"last_name":"Ebbert","full_name":"Ebbert, Christoph","first_name":"Christoph"},{"first_name":"Vanessa","full_name":"Neßlinger, Vanessa","last_name":"Neßlinger"},{"full_name":"Keller, Adrian","last_name":"Keller","first_name":"Adrian"},{"first_name":"Guido","last_name":"Grundmeier","full_name":"Grundmeier, Guido"}]},{"citation":{"chicago":"Hanke, Marcel, Emilia Tomm, Guido Grundmeier, and Adrian Keller. “Effect of Ionic Strength on the Thermal Stability of DNA Origami Nanostructures.” <i>ChemBioChem</i>, 2023. <a href=\"https://doi.org/10.1002/cbic.202300338\">https://doi.org/10.1002/cbic.202300338</a>.","ieee":"M. Hanke, E. Tomm, G. Grundmeier, and A. Keller, “Effect of Ionic Strength on the Thermal Stability of DNA Origami Nanostructures,” <i>ChemBioChem</i>, 2023, doi: <a href=\"https://doi.org/10.1002/cbic.202300338\">10.1002/cbic.202300338</a>.","ama":"Hanke M, Tomm E, Grundmeier G, Keller A. Effect of Ionic Strength on the Thermal Stability of DNA Origami Nanostructures. <i>ChemBioChem</i>. Published online 2023. doi:<a href=\"https://doi.org/10.1002/cbic.202300338\">10.1002/cbic.202300338</a>","bibtex":"@article{Hanke_Tomm_Grundmeier_Keller_2023, title={Effect of Ionic Strength on the Thermal Stability of DNA Origami Nanostructures}, DOI={<a href=\"https://doi.org/10.1002/cbic.202300338\">10.1002/cbic.202300338</a>}, journal={ChemBioChem}, publisher={Wiley}, author={Hanke, Marcel and Tomm, Emilia and Grundmeier, Guido and Keller, Adrian}, year={2023} }","short":"M. Hanke, E. Tomm, G. Grundmeier, A. Keller, ChemBioChem (2023).","mla":"Hanke, Marcel, et al. “Effect of Ionic Strength on the Thermal Stability of DNA Origami Nanostructures.” <i>ChemBioChem</i>, Wiley, 2023, doi:<a href=\"https://doi.org/10.1002/cbic.202300338\">10.1002/cbic.202300338</a>.","apa":"Hanke, M., Tomm, E., Grundmeier, G., &#38; Keller, A. (2023). Effect of Ionic Strength on the Thermal Stability of DNA Origami Nanostructures. <i>ChemBioChem</i>. <a href=\"https://doi.org/10.1002/cbic.202300338\">https://doi.org/10.1002/cbic.202300338</a>"},"year":"2023","publication_identifier":{"issn":["1439-4227","1439-7633"]},"publication_status":"published","doi":"10.1002/cbic.202300338","title":"Effect of Ionic Strength on the Thermal Stability of DNA Origami Nanostructures","author":[{"full_name":"Hanke, Marcel","last_name":"Hanke","first_name":"Marcel"},{"last_name":"Tomm","full_name":"Tomm, Emilia","first_name":"Emilia"},{"first_name":"Guido","full_name":"Grundmeier, Guido","id":"194","last_name":"Grundmeier"},{"full_name":"Keller, Adrian","id":"48864","orcid":"0000-0001-7139-3110","last_name":"Keller","first_name":"Adrian"}],"date_created":"2023-05-05T10:47:29Z","date_updated":"2023-05-05T10:48:00Z","publisher":"Wiley","status":"public","publication":"ChemBioChem","type":"journal_article","language":[{"iso":"eng"}],"keyword":["Organic Chemistry","Molecular Biology","Molecular Medicine","Biochemistry"],"department":[{"_id":"302"}],"user_id":"48864","_id":"44503"},{"publication_identifier":{"issn":["1420-3049"]},"publication_status":"published","page":"5109","intvolume":"        28","citation":{"ieee":"B. Duderija, A. González-Orive, C. Ebbert, V. Neßlinger, A. Keller, and G. Grundmeier, “Electrode Potential-Dependent Studies of Protein Adsorption on Ti6Al4V Alloy,” <i>Molecules</i>, vol. 28, no. 13, p. 5109, 2023, doi: <a href=\"https://doi.org/10.3390/molecules28135109\">10.3390/molecules28135109</a>.","chicago":"Duderija, Belma, Alejandro González-Orive, Christoph Ebbert, Vanessa Neßlinger, Adrian Keller, and Guido Grundmeier. “Electrode Potential-Dependent Studies of Protein Adsorption on Ti6Al4V Alloy.” <i>Molecules</i> 28, no. 13 (2023): 5109. <a href=\"https://doi.org/10.3390/molecules28135109\">https://doi.org/10.3390/molecules28135109</a>.","ama":"Duderija B, González-Orive A, Ebbert C, Neßlinger V, Keller A, Grundmeier G. Electrode Potential-Dependent Studies of Protein Adsorption on Ti6Al4V Alloy. <i>Molecules</i>. 2023;28(13):5109. doi:<a href=\"https://doi.org/10.3390/molecules28135109\">10.3390/molecules28135109</a>","apa":"Duderija, B., González-Orive, A., Ebbert, C., Neßlinger, V., Keller, A., &#38; Grundmeier, G. (2023). Electrode Potential-Dependent Studies of Protein Adsorption on Ti6Al4V Alloy. <i>Molecules</i>, <i>28</i>(13), 5109. <a href=\"https://doi.org/10.3390/molecules28135109\">https://doi.org/10.3390/molecules28135109</a>","mla":"Duderija, Belma, et al. “Electrode Potential-Dependent Studies of Protein Adsorption on Ti6Al4V Alloy.” <i>Molecules</i>, vol. 28, no. 13, MDPI AG, 2023, p. 5109, doi:<a href=\"https://doi.org/10.3390/molecules28135109\">10.3390/molecules28135109</a>.","bibtex":"@article{Duderija_González-Orive_Ebbert_Neßlinger_Keller_Grundmeier_2023, title={Electrode Potential-Dependent Studies of Protein Adsorption on Ti6Al4V Alloy}, volume={28}, DOI={<a href=\"https://doi.org/10.3390/molecules28135109\">10.3390/molecules28135109</a>}, number={13}, journal={Molecules}, publisher={MDPI AG}, author={Duderija, Belma and González-Orive, Alejandro and Ebbert, Christoph and Neßlinger, Vanessa and Keller, Adrian and Grundmeier, Guido}, year={2023}, pages={5109} }","short":"B. Duderija, A. González-Orive, C. Ebbert, V. Neßlinger, A. Keller, G. Grundmeier, Molecules 28 (2023) 5109."},"volume":28,"author":[{"last_name":"Duderija","id":"54863","full_name":"Duderija, Belma","first_name":"Belma"},{"full_name":"González-Orive, Alejandro","last_name":"González-Orive","first_name":"Alejandro"},{"first_name":"Christoph","last_name":"Ebbert","full_name":"Ebbert, Christoph","id":"7266"},{"first_name":"Vanessa","full_name":"Neßlinger, Vanessa","last_name":"Neßlinger"},{"first_name":"Adrian","orcid":"0000-0001-7139-3110","last_name":"Keller","id":"48864","full_name":"Keller, Adrian"},{"last_name":"Grundmeier","id":"194","full_name":"Grundmeier, Guido","first_name":"Guido"}],"date_updated":"2023-07-03T08:07:55Z","doi":"10.3390/molecules28135109","type":"journal_article","status":"public","department":[{"_id":"302"}],"user_id":"48864","_id":"45828","issue":"13","year":"2023","date_created":"2023-07-03T08:06:28Z","publisher":"MDPI AG","title":"Electrode Potential-Dependent Studies of Protein Adsorption on Ti6Al4V Alloy","publication":"Molecules","abstract":[{"text":"<jats:p>This article presents the potential-dependent adsorption of two proteins, bovine serum albumin (BSA) and lysozyme (LYZ), on Ti6Al4V alloy at pH 7.4 and 37 °C. The adsorption process was studied on an electropolished alloy under cathodic and anodic overpotentials, compared to the open circuit potential (OCP). To analyze the adsorption process, various complementary interface analytical techniques were employed, including PM-IRRAS (polarization-modulation infrared reflection-absorption spectroscopy), AFM (atomic force microscopy), XPS (X-ray photoelectron spectroscopy), and E-QCM (electrochemical quartz crystal microbalance) measurements. The polarization experiments were conducted within a potential range where charging of the electric double layer dominates, and Faradaic currents can be disregarded. The findings highlight the significant influence of the interfacial charge distribution on the adsorption of BSA and LYZ onto the alloy surface. Furthermore, electrochemical analysis of the protein layers formed under applied overpotentials demonstrated improved corrosion protection properties. These studies provide valuable insights into protein adsorption on titanium alloys under physiological conditions, characterized by varying potentials of the passive alloy.</jats:p>","lang":"eng"}],"language":[{"iso":"eng"}],"keyword":["Chemistry (miscellaneous)","Analytical Chemistry","Organic Chemistry","Physical and Theoretical Chemistry","Molecular Medicine","Drug Discovery","Pharmaceutical Science"]},{"publication_status":"published","publication_identifier":{"issn":["1420-3049"]},"citation":{"ieee":"J. Huang, Y. Qiu, F. Lücke, J. Su, G. Grundmeier, and A. Keller, “Multiprotein Adsorption from Human Serum at Gold and Oxidized Iron Surfaces Studied by Atomic Force Microscopy and Polarization-Modulation Infrared Reflection Absorption Spectroscopy,” <i>Molecules</i>, vol. 28, no. 16, Art. no. 6060, 2023, doi: <a href=\"https://doi.org/10.3390/molecules28166060\">10.3390/molecules28166060</a>.","chicago":"Huang, Jingyuan, Yunshu Qiu, Felix Lücke, Jiangling Su, Guido Grundmeier, and Adrian Keller. “Multiprotein Adsorption from Human Serum at Gold and Oxidized Iron Surfaces Studied by Atomic Force Microscopy and Polarization-Modulation Infrared Reflection Absorption Spectroscopy.” <i>Molecules</i> 28, no. 16 (2023). <a href=\"https://doi.org/10.3390/molecules28166060\">https://doi.org/10.3390/molecules28166060</a>.","ama":"Huang J, Qiu Y, Lücke F, Su J, Grundmeier G, Keller A. Multiprotein Adsorption from Human Serum at Gold and Oxidized Iron Surfaces Studied by Atomic Force Microscopy and Polarization-Modulation Infrared Reflection Absorption Spectroscopy. <i>Molecules</i>. 2023;28(16). doi:<a href=\"https://doi.org/10.3390/molecules28166060\">10.3390/molecules28166060</a>","apa":"Huang, J., Qiu, Y., Lücke, F., Su, J., Grundmeier, G., &#38; Keller, A. (2023). Multiprotein Adsorption from Human Serum at Gold and Oxidized Iron Surfaces Studied by Atomic Force Microscopy and Polarization-Modulation Infrared Reflection Absorption Spectroscopy. <i>Molecules</i>, <i>28</i>(16), Article 6060. <a href=\"https://doi.org/10.3390/molecules28166060\">https://doi.org/10.3390/molecules28166060</a>","mla":"Huang, Jingyuan, et al. “Multiprotein Adsorption from Human Serum at Gold and Oxidized Iron Surfaces Studied by Atomic Force Microscopy and Polarization-Modulation Infrared Reflection Absorption Spectroscopy.” <i>Molecules</i>, vol. 28, no. 16, 6060, MDPI AG, 2023, doi:<a href=\"https://doi.org/10.3390/molecules28166060\">10.3390/molecules28166060</a>.","short":"J. Huang, Y. Qiu, F. Lücke, J. Su, G. Grundmeier, A. Keller, Molecules 28 (2023).","bibtex":"@article{Huang_Qiu_Lücke_Su_Grundmeier_Keller_2023, title={Multiprotein Adsorption from Human Serum at Gold and Oxidized Iron Surfaces Studied by Atomic Force Microscopy and Polarization-Modulation Infrared Reflection Absorption Spectroscopy}, volume={28}, DOI={<a href=\"https://doi.org/10.3390/molecules28166060\">10.3390/molecules28166060</a>}, number={166060}, journal={Molecules}, publisher={MDPI AG}, author={Huang, Jingyuan and Qiu, Yunshu and Lücke, Felix and Su, Jiangling and Grundmeier, Guido and Keller, Adrian}, year={2023} }"},"intvolume":"        28","date_updated":"2023-08-16T10:53:08Z","author":[{"first_name":"Jingyuan","full_name":"Huang, Jingyuan","last_name":"Huang"},{"last_name":"Qiu","full_name":"Qiu, Yunshu","first_name":"Yunshu"},{"first_name":"Felix","last_name":"Lücke","full_name":"Lücke, Felix"},{"first_name":"Jiangling","full_name":"Su, Jiangling","last_name":"Su"},{"full_name":"Grundmeier, Guido","id":"194","last_name":"Grundmeier","first_name":"Guido"},{"first_name":"Adrian","full_name":"Keller, Adrian","id":"48864","last_name":"Keller","orcid":"0000-0001-7139-3110"}],"volume":28,"doi":"10.3390/molecules28166060","type":"journal_article","status":"public","_id":"46542","user_id":"48864","department":[{"_id":"302"}],"article_number":"6060","issue":"16","year":"2023","publisher":"MDPI AG","date_created":"2023-08-16T10:51:48Z","title":"Multiprotein Adsorption from Human Serum at Gold and Oxidized Iron Surfaces Studied by Atomic Force Microscopy and Polarization-Modulation Infrared Reflection Absorption Spectroscopy","publication":"Molecules","abstract":[{"text":"<jats:p>Multiprotein adsorption from complex body fluids represents a highly important and complicated phenomenon in medicine. In this work, multiprotein adsorption from diluted human serum at gold and oxidized iron surfaces is investigated at different serum concentrations and pH values. Adsorption-induced changes in surface topography and the total amount of adsorbed proteins are quantified by atomic force microscopy (AFM) and polarization-modulation infrared reflection absorption spectroscopy (PM-IRRAS), respectively. For both surfaces, stronger protein adsorption is observed at pH 6 compared to pH 7 and pH 8. PM-IRRAS furthermore provides some qualitative insights into the pH-dependent alterations in the composition of the adsorbed multiprotein films. Changes in the amide II/amide I band area ratio and in particular side-chain IR absorption suggest that the increased adsorption at pH 6 is accompanied by a change in protein film composition. Presumably, this is mostly driven by the adsorption of human serum albumin, which at pH 6 adsorbs more readily and thereby replaces other proteins with lower surface affinities in the resulting multiprotein film.</jats:p>","lang":"eng"}],"keyword":["Chemistry (miscellaneous)","Analytical Chemistry","Organic Chemistry","Physical and Theoretical Chemistry","Molecular Medicine","Drug Discovery","Pharmaceutical Science"],"language":[{"iso":"eng"}]},{"year":"2022","intvolume":"        14","page":"e13952","citation":{"ieee":"J. Ring <i>et al.</i>, “The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity,” <i>EMBO Molecular Medicine</i>, vol. 14, p. e13952, 2022, doi: <a href=\"https://doi.org/10.15252/emmm.202113952\">10.15252/emmm.202113952</a>.","chicago":"Ring, Julia, Jelena Tadic, Selena Ristic, Michael Poglitsch, Martina Bergmann, Nemanja Radic, Dirk Mossmann, et al. “The HSP40 Chaperone Ydj1 Drives Amyloid Beta 42 Toxicity.” <i>EMBO Molecular Medicine</i> 14 (2022): e13952. <a href=\"https://doi.org/10.15252/emmm.202113952\">https://doi.org/10.15252/emmm.202113952</a>.","ama":"Ring J, Tadic J, Ristic S, et al. The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity. <i>EMBO Molecular Medicine</i>. 2022;14:e13952. doi:<a href=\"https://doi.org/10.15252/emmm.202113952\">10.15252/emmm.202113952</a>","apa":"Ring, J., Tadic, J., Ristic, S., Poglitsch, M., Bergmann, M., Radic, N., Mossmann, D., Liang, Y., Maglione, M., Jerkovic, A., Hajiraissi, R., Hanke, M., Küttner, V., Wolinski, H., Zimmermann, A., Domuz Trifunović, L., Mikolasch, L., Moretti, D. N., Broeskamp, F., … Madeo, F. (2022). The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity. <i>EMBO Molecular Medicine</i>, <i>14</i>, e13952. <a href=\"https://doi.org/10.15252/emmm.202113952\">https://doi.org/10.15252/emmm.202113952</a>","mla":"Ring, Julia, et al. “The HSP40 Chaperone Ydj1 Drives Amyloid Beta 42 Toxicity.” <i>EMBO Molecular Medicine</i>, vol. 14, EMBO, 2022, p. e13952, doi:<a href=\"https://doi.org/10.15252/emmm.202113952\">10.15252/emmm.202113952</a>.","short":"J. Ring, J. Tadic, S. Ristic, M. Poglitsch, M. Bergmann, N. Radic, D. Mossmann, Y. Liang, M. Maglione, A. Jerkovic, R. Hajiraissi, M. Hanke, V. Küttner, H. Wolinski, A. Zimmermann, L. Domuz Trifunović, L. Mikolasch, D.N. Moretti, F. Broeskamp, J. Westermayer, C. Abraham, S. Schauer, C. Dammbrueck, S.J. Hofer, M. Abdellatif, G. Grundmeier, G. Kroemer, R.J. Braun, N. Hansen, C. Sommer, M. Ninkovic, S. Seba, P. Rockenfeller, F. Vögtle, J. Dengjel, C. Meisinger, A. Keller, S.J. Sigrist, T. Eisenberg, F. Madeo, EMBO Molecular Medicine 14 (2022) e13952.","bibtex":"@article{Ring_Tadic_Ristic_Poglitsch_Bergmann_Radic_Mossmann_Liang_Maglione_Jerkovic_et al._2022, title={The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity}, volume={14}, DOI={<a href=\"https://doi.org/10.15252/emmm.202113952\">10.15252/emmm.202113952</a>}, journal={EMBO Molecular Medicine}, publisher={EMBO}, author={Ring, Julia and Tadic, Jelena and Ristic, Selena and Poglitsch, Michael and Bergmann, Martina and Radic, Nemanja and Mossmann, Dirk and Liang, YongTian and Maglione, Marta and Jerkovic, Andrea and et al.}, year={2022}, pages={e13952} }"},"publication_identifier":{"issn":["1757-4676","1757-4684"]},"publication_status":"published","title":"The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity","doi":"10.15252/emmm.202113952","date_updated":"2022-05-09T12:28:24Z","publisher":"EMBO","volume":14,"author":[{"last_name":"Ring","full_name":"Ring, Julia","first_name":"Julia"},{"full_name":"Tadic, Jelena","last_name":"Tadic","first_name":"Jelena"},{"last_name":"Ristic","full_name":"Ristic, Selena","first_name":"Selena"},{"last_name":"Poglitsch","full_name":"Poglitsch, Michael","first_name":"Michael"},{"first_name":"Martina","full_name":"Bergmann, Martina","last_name":"Bergmann"},{"last_name":"Radic","full_name":"Radic, Nemanja","first_name":"Nemanja"},{"last_name":"Mossmann","full_name":"Mossmann, Dirk","first_name":"Dirk"},{"first_name":"YongTian","full_name":"Liang, YongTian","last_name":"Liang"},{"first_name":"Marta","last_name":"Maglione","full_name":"Maglione, Marta"},{"full_name":"Jerkovic, Andrea","last_name":"Jerkovic","first_name":"Andrea"},{"first_name":"Roozbeh","full_name":"Hajiraissi, Roozbeh","last_name":"Hajiraissi"},{"first_name":"Marcel","full_name":"Hanke, Marcel","last_name":"Hanke"},{"first_name":"Victoria","full_name":"Küttner, Victoria","last_name":"Küttner"},{"first_name":"Heimo","full_name":"Wolinski, Heimo","last_name":"Wolinski"},{"last_name":"Zimmermann","full_name":"Zimmermann, Andreas","first_name":"Andreas"},{"last_name":"Domuz Trifunović","full_name":"Domuz Trifunović, Lana","first_name":"Lana"},{"last_name":"Mikolasch","full_name":"Mikolasch, Leonie","first_name":"Leonie"},{"first_name":"Daiana N","last_name":"Moretti","full_name":"Moretti, Daiana N"},{"last_name":"Broeskamp","full_name":"Broeskamp, Filomena","first_name":"Filomena"},{"first_name":"Julia","full_name":"Westermayer, Julia","last_name":"Westermayer"},{"first_name":"Claudia","full_name":"Abraham, Claudia","last_name":"Abraham"},{"first_name":"Simon","last_name":"Schauer","full_name":"Schauer, Simon"},{"full_name":"Dammbrueck, Christopher","last_name":"Dammbrueck","first_name":"Christopher"},{"first_name":"Sebastian J","last_name":"Hofer","full_name":"Hofer, Sebastian J"},{"first_name":"Mahmoud","full_name":"Abdellatif, Mahmoud","last_name":"Abdellatif"},{"first_name":"Guido","last_name":"Grundmeier","id":"194","full_name":"Grundmeier, Guido"},{"first_name":"Guido","last_name":"Kroemer","full_name":"Kroemer, Guido"},{"full_name":"Braun, Ralf J","last_name":"Braun","first_name":"Ralf J"},{"full_name":"Hansen, Niklas","last_name":"Hansen","first_name":"Niklas"},{"first_name":"Cornelia","last_name":"Sommer","full_name":"Sommer, Cornelia"},{"last_name":"Ninkovic","full_name":"Ninkovic, Mirjana","first_name":"Mirjana"},{"first_name":"Sandra","full_name":"Seba, Sandra","last_name":"Seba"},{"full_name":"Rockenfeller, Patrick","last_name":"Rockenfeller","first_name":"Patrick"},{"full_name":"Vögtle, Friederike‐Nora","last_name":"Vögtle","first_name":"Friederike‐Nora"},{"full_name":"Dengjel, Jörn","last_name":"Dengjel","first_name":"Jörn"},{"first_name":"Chris","last_name":"Meisinger","full_name":"Meisinger, Chris"},{"orcid":"0000-0001-7139-3110","last_name":"Keller","full_name":"Keller, Adrian","id":"48864","first_name":"Adrian"},{"first_name":"Stephan J","full_name":"Sigrist, Stephan J","last_name":"Sigrist"},{"first_name":"Tobias","last_name":"Eisenberg","full_name":"Eisenberg, Tobias"},{"first_name":"Frank","last_name":"Madeo","full_name":"Madeo, Frank"}],"date_created":"2022-04-04T14:27:15Z","status":"public","publication":"EMBO Molecular Medicine","type":"journal_article","keyword":["Molecular Medicine"],"language":[{"iso":"eng"}],"_id":"30739","department":[{"_id":"302"}],"user_id":"48864"},{"publication_status":"published","publication_identifier":{"issn":["1664-8021"]},"year":"2021","citation":{"short":"T. Peters, J. Antel, R. Naaresh, B.-H. Laabs, M. Föcker, N. Albers, J. Bühlmeier, A. Hinney, L. Libuda, J. Hebebrand, Frontiers in Genetics 12 (2021).","bibtex":"@article{Peters_Antel_Naaresh_Laabs_Föcker_Albers_Bühlmeier_Hinney_Libuda_Hebebrand_2021, title={Suggestive Evidence for Causal Effect of Leptin Levels on Risk for Anorexia Nervosa: Results of a Mendelian Randomization Study}, volume={12}, DOI={<a href=\"https://doi.org/10.3389/fgene.2021.733606\">10.3389/fgene.2021.733606</a>}, journal={Frontiers in Genetics}, publisher={Frontiers Media SA}, author={Peters, Triinu and Antel, Jochen and Naaresh, Roaa and Laabs, Björn-Hergen and Föcker, Manuel and Albers, Nicola and Bühlmeier, Judith and Hinney, Anke and Libuda, Lars and Hebebrand, Johannes}, year={2021} }","mla":"Peters, Triinu, et al. “Suggestive Evidence for Causal Effect of Leptin Levels on Risk for Anorexia Nervosa: Results of a Mendelian Randomization Study.” <i>Frontiers in Genetics</i>, vol. 12, Frontiers Media SA, 2021, doi:<a href=\"https://doi.org/10.3389/fgene.2021.733606\">10.3389/fgene.2021.733606</a>.","apa":"Peters, T., Antel, J., Naaresh, R., Laabs, B.-H., Föcker, M., Albers, N., Bühlmeier, J., Hinney, A., Libuda, L., &#38; Hebebrand, J. (2021). Suggestive Evidence for Causal Effect of Leptin Levels on Risk for Anorexia Nervosa: Results of a Mendelian Randomization Study. <i>Frontiers in Genetics</i>, <i>12</i>. <a href=\"https://doi.org/10.3389/fgene.2021.733606\">https://doi.org/10.3389/fgene.2021.733606</a>","ama":"Peters T, Antel J, Naaresh R, et al. Suggestive Evidence for Causal Effect of Leptin Levels on Risk for Anorexia Nervosa: Results of a Mendelian Randomization Study. <i>Frontiers in Genetics</i>. 2021;12. doi:<a href=\"https://doi.org/10.3389/fgene.2021.733606\">10.3389/fgene.2021.733606</a>","chicago":"Peters, Triinu, Jochen Antel, Roaa Naaresh, Björn-Hergen Laabs, Manuel Föcker, Nicola Albers, Judith Bühlmeier, Anke Hinney, Lars Libuda, and Johannes Hebebrand. “Suggestive Evidence for Causal Effect of Leptin Levels on Risk for Anorexia Nervosa: Results of a Mendelian Randomization Study.” <i>Frontiers in Genetics</i> 12 (2021). <a href=\"https://doi.org/10.3389/fgene.2021.733606\">https://doi.org/10.3389/fgene.2021.733606</a>.","ieee":"T. Peters <i>et al.</i>, “Suggestive Evidence for Causal Effect of Leptin Levels on Risk for Anorexia Nervosa: Results of a Mendelian Randomization Study,” <i>Frontiers in Genetics</i>, vol. 12, 2021, doi: <a href=\"https://doi.org/10.3389/fgene.2021.733606\">10.3389/fgene.2021.733606</a>."},"intvolume":"        12","publisher":"Frontiers Media SA","date_updated":"2022-08-30T13:11:49Z","date_created":"2022-07-06T15:10:40Z","author":[{"last_name":"Peters","full_name":"Peters, Triinu","first_name":"Triinu"},{"full_name":"Antel, Jochen","last_name":"Antel","first_name":"Jochen"},{"last_name":"Naaresh","full_name":"Naaresh, Roaa","first_name":"Roaa"},{"first_name":"Björn-Hergen","last_name":"Laabs","full_name":"Laabs, Björn-Hergen"},{"first_name":"Manuel","last_name":"Föcker","full_name":"Föcker, Manuel"},{"full_name":"Albers, Nicola","last_name":"Albers","first_name":"Nicola"},{"last_name":"Bühlmeier","full_name":"Bühlmeier, Judith","first_name":"Judith"},{"full_name":"Hinney, Anke","last_name":"Hinney","first_name":"Anke"},{"first_name":"Lars","last_name":"Libuda","full_name":"Libuda, Lars"},{"first_name":"Johannes","last_name":"Hebebrand","full_name":"Hebebrand, Johannes"}],"volume":12,"title":"Suggestive Evidence for Causal Effect of Leptin Levels on Risk for Anorexia Nervosa: Results of a Mendelian Randomization Study","doi":"10.3389/fgene.2021.733606","type":"journal_article","publication":"Frontiers in Genetics","abstract":[{"text":"<jats:p>Genetic correlations suggest a coexisting genetic predisposition to both low leptin levels and risk for anorexia nervosa (AN). To investigate the causality and direction of these associations, we performed bidirectional two-sample Mendelian randomization (MR) analyses using data of the most recent genome-wide association study (GWAS) for AN and both a GWAS and an exome-wide-association-study (EWAS) for leptin levels. Most MR methods with genetic instruments from GWAS showed a causal effect of lower leptin levels on higher risk of AN (e.g. IVW b = −0.923, <jats:italic>p</jats:italic> = 1.5 × 10<jats:sup>−4</jats:sup>). Because most patients with AN are female, we additionally performed analyses using leptin GWAS data of females only. Again, there was a significant effect of leptin levels on the risk of AN (e.g. IVW b = −0.826, <jats:italic>p</jats:italic> = 1.1 × 10<jats:sup>−04</jats:sup>). MR with genetic instruments from EWAS showed no overall effect of leptin levels on the risk for AN. For the opposite direction, MR revealed no causal effect of AN on leptin levels. If our results are confirmed in extended GWAS data sets, a low endogenous leptin synthesis represents a risk factor for developing AN.</jats:p>","lang":"eng"}],"status":"public","_id":"32323","user_id":"88682","department":[{"_id":"35"}],"keyword":["Genetics (clinical)","Genetics","Molecular Medicine"],"language":[{"iso":"eng"}]}]