@article{50798, abstract = {{Abstract Background An infection with SARS-CoV-2 can lead to a variety of symptoms and complications, which can impair athletic activity. Objective We aimed to assess the clinical symptom patterns, diagnostic findings, and the extent of impairment in sport practice in a large cohort of athletes infected with SARS-CoV-2, both initially after infection and at follow-up. Additionally, we investigated whether baseline factors that may contribute to reduced exercise tolerance at follow-up can be identified. Methods In this prospective, observational, multicenter study, we recruited German COVID elite-athletes (cEAs, n = 444) and COVID non-elite athletes (cNEAs, n = 481) who tested positive for SARS-CoV-2 by PCR (polymerase chain reaction test). Athletes from the federal squad with no evidence of SARS-CoV-2 infection served as healthy controls (EAcon, n = 501). Questionnaires were used to assess load and duration of infectious symptoms, other complaints, exercise tolerance, and duration of training interruption at baseline and at follow-up 6 months after baseline. Diagnostic tests conducted at baseline included resting and exercise electrocardiogram (ECG), echocardiography, spirometry, and blood analyses. Results Most acute and infection-related symptoms and other complaints were more prevalent in cNEA than in cEAs. Compared to cEAs, EAcon had a low symptom load. In cNEAs, female athletes had a higher prevalence of complaints such as palpitations, dizziness, chest pain, myalgia, sleeping disturbances, mood swings, and concentration problems compared to male athletes (p < 0.05). Until follow-up, leading symptoms were drop in performance, concentration problems, and dyspnea on exertion. Female athletes had significantly higher prevalence for symptoms until follow-up compared to male. Pathological findings in ECG, echocardiography, and spirometry, attributed to SARS-CoV-2 infection, were rare in infected athletes. Most athletes reported a training interruption between 2 and 4 weeks (cNEAs: 52.9%, cEAs: 52.4%), while more cNEAs (27.1%) compared to cEAs (5.1%) had a training interruption lasting more than 4 weeks (p < 0.001). At follow-up, 13.8% of cNEAs and 9.9% of cEAs (p = 0.24) reported their current exercise tolerance to be under 70% compared to pre-infection state. A persistent loss of exercise tolerance at follow-up was associated with persistent complaints at baseline, female sex, a longer break in training, and age > 38 years. Periodical dichotomization of the data set showed a higher prevalence of infectious symptoms such as cough, sore throat, and coryza in the second phase of the pandemic, while a number of neuropsychiatric symptoms as well as dyspnea on exertion were less frequent in this period. Conclusions Compared to recreational athletes, elite athletes seem to be at lower risk of being or remaining symptomatic after SARS-CoV-2 infection. It remains to be determined whether persistent complaints after SARS-CoV-2 infection without evidence of accompanying organ damage may have a negative impact on further health and career in athletes. Identifying risk factors for an extended recovery period such as female sex and ongoing neuropsychological symptoms could help to identify athletes, who may require a more cautious approach to rebuilding their training regimen. Trial Registration Number DRKS00023717; 06.15.2021—retrospectively registered. }}, author = {{Widmann, Manuel and Gaidai, Roman and Schubert, Isabel and Grummt, Maximilian and Bensen, Lieselotte and Kerling, Arno and Quermann, Anne and Zacher, Jonas and Vollrath, Shirin and Bizjak, Daniel Alexander and Beckendorf, Claudia and Egger, Florian and Hasler, Erik and Mellwig, Klaus-Peter and Fütterer, Cornelia and Wimbauer, Fritz and Vogel, Azin and Schoenfeld, Julia and Wüstenfeld, Jan C. and Kastner, Tom and Barsch, Friedrich and Friedmann-Bette, Birgit and Bloch, Wilhelm and Meyer, Tim and Mayer, Frank and Wolfarth, Bernd and Roecker, Kai and Reinsberger, Claus and Haller, Bernhard and Niess, Andreas M. and Birnbaum, Mike Peter and Burgstahler, Christof and Cassel, Michael and Deibert, Peter and Esefeld, Katrin and Erz, Gunnar and Greiss, Franziska and Halle, Martin and Hesse, Judith and Keller, Karsten and Kopp, Christine and Matits, Lynn and Predel, Hans Georg and Rüdrich, Peter and Schneider, Gerald and Stapmanns, Philipp and Steinacker, Jürgen Michael and Szekessy, Sarah and Venhorst, Andreas and Zapf, Stephanie and Zickwolf, Christian}}, issn = {{0112-1642}}, journal = {{Sports Medicine}}, keywords = {{Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{COVID-19 in Female and Male Athletes: Symptoms, Clinical Findings, Outcome, and Prolonged Exercise Intolerance—A Prospective, Observational, Multicenter Cohort Study (CoSmo-S)}}}, doi = {{10.1007/s40279-023-01976-0}}, year = {{2024}}, } @article{35533, author = {{Büchel, Daniel and Torvik, Per Øyvind and Lehmann, Tim and Sandbakk, Øyvind and Baumeister, Jochen}}, issn = {{1530-0315}}, journal = {{Medicine & Science in Sports & Exercise}}, keywords = {{Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine}}, publisher = {{Ovid Technologies (Wolters Kluwer Health)}}, title = {{{The Mode of Endurance Exercise Influences Changes in EEG Resting State Graphs among High-Level Cross-Country Skiers}}}, doi = {{10.1249/mss.0000000000003122}}, volume = {{Publish Ahead of Print}}, year = {{2023}}, } @article{42118, author = {{Haase, Franziska Katharina and Prien, Annika and Douw, Linda and Feddermann‐Demont, Nina and Junge, Astrid and Reinsberger, Claus}}, issn = {{0905-7188}}, journal = {{Scandinavian Journal of Medicine & Science in Sports}}, keywords = {{Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine}}, publisher = {{Wiley}}, title = {{{Cortical thickness and neurocognitive performance in former high‐level female soccer and non‐contact sport athletes}}}, doi = {{10.1111/sms.14324}}, year = {{2023}}, } @article{42966, author = {{Sherman, David A. and Baumeister, Jochen and Stock, Matt S. and Murray, Amanda M. and Bazett-Jones, David M. and Norte, Grant E.}}, issn = {{1530-0315}}, journal = {{Medicine & Science in Sports & Exercise}}, keywords = {{Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine}}, publisher = {{Ovid Technologies (Wolters Kluwer Health)}}, title = {{{Weaker Quadriceps Corticomuscular Coherence in Individuals Following ACL Reconstruction during Force Tracing}}}, doi = {{10.1249/mss.0000000000003080}}, volume = {{Publish Ahead of Print}}, year = {{2023}}, } @article{45154, author = {{Gokeler, Alli and Nijmeijer, E. M. and Heuvelmans, P. and Tak, I. and Ramponi, C. and Benjaminse, A.}}, issn = {{0933-7946}}, journal = {{Arthroskopie}}, keywords = {{Orthopedics and Sports Medicine}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Motor learning principles during rehabilitation after anterior cruciate ligament injury Prinzipien motorischen Lernens während der Rehabilitation nach vorderer Kreuzbandverletzung}}}, doi = {{10.1007/s00142-023-00606-1}}, year = {{2023}}, } @article{46818, abstract = {{AbstractObjectiveConcerns about short‐ and long‐term consequences of repetitive heading contributed to heading restrictions in youth football in some countries. This prospective longitudinal cohort study aims to describe heading exposure in children's and youth football over two seasons using standardized video analysis.MethodsAll matches and training sessions of a male Under‐11 (n = 29), Under‐15 (n = 28), Under‐19 (n = 38), and female Under‐17 (n = 39) team were videotaped during the seasons 2019–2020 and 2020–2021. Heading frequencies and characteristics were analyzed. Individual heading exposure is presented as average incidence rates (IR) per 1000 match/training hours.ResultsIn 275 matches and 673 training sessions, 22 921 headers were observed. Heading IR per player in matches was 1256 (Under‐11 m), 1608 (Under‐15 m), 1050 (Under‐17 f), and 1966 (Under‐19 m). In training sessions, IR per player was 739 (Under‐11 m), 2206 (Under‐15 m), 1661 (Under‐17 f), and 1419 (Under‐19 m). Five Under‐15 males headed the ball five to eight times per training on average. Most headers were performed without heading duels. Flight distance was predominantly 5–20 m (54%) in matches and <5 m (65%) in training. While head impact location most frequently was at frontal areas, one‐third of all headers in Under‐11 in matches hit temporal, parietal, and occipital parts of the head.ConclusionHeading incidence was low in the youngest age group, whereas (predominantly five) Under‐15 males showed very high heading exposures in training. In assessment and regulation of heading burden, training sessions and individual heading behavior should specifically be addressed. Recommendations for heading the ball in practice should account for individual and age‐related differences.}}, author = {{Reeschke, Rebecca and Haase, Franziska Katharina and Dautzenberg, Lena and Krutsch, Werner and Reinsberger, Claus}}, issn = {{0905-7188}}, journal = {{Scandinavian Journal of Medicine & Science in Sports}}, keywords = {{Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine}}, number = {{9}}, pages = {{1821--1830}}, publisher = {{Wiley}}, title = {{{Training matters: Heading incidence and characteristics in children's and youth football (soccer) players}}}, doi = {{10.1111/sms.14408}}, volume = {{33}}, year = {{2023}}, } @article{37466, abstract = {{Typically, head fakes in basketball are generated to, and actually do, deteriorate performance on the side of the observer. However, potential costs at the side of the producer of a fake action have only rarely been investigated before. It is thus not clear yet if the benefit (i.e., slowed reactions in the observer) of performing a head fake is overestimated due to concurrently arising fake production costs (i.e., slowed performance in the producer of a head fake). Therefore, we studied potential head-fake production costs with two experiments. Novice participants were asked to generate passes to the left or right side, either with or without head fakes. In Experiment 1, these actions were determined by an auditory stimulus (i.e., a 440 Hz or 1200 Hz sinus or jigsaw wave). After an interstimulus interval (ISI) of either 0 ms, 800 ms, or 1500 ms, which served the preparation of the action, the cued action had to be executed. In Experiment 2, passing to the left or right, either with or without a head fake, was determined by a visual stimulus (i.e., a player with a red or blue jersey defending either the right or left side). After an ISI of either 0 ms, 400 ms, 800 ms, or 1200 ms, the cued action had to be executed. In both experiments, we observed higher reaction times (RTs) for passes with head fakes as compared to passes without head fakes for no and an intermediate preparation interval (from ISI 0 ms to 800 ms), but no difference for a long preparation interval (for an ISI of 1200 ms and 1500 ms). Both experiments show that generating fake actions produces performance costs, however, these costs can be overcome by a longer preparation phase before movement execution.}}, author = {{Güldenpenning, Iris and Weigelt, Matthias and Böer, Nils Tobias and Kunde, Wilfried}}, issn = {{0167-9457}}, journal = {{Human Movement Science}}, keywords = {{Experimental and Cognitive Psychology, Orthopedics and Sports Medicine, General Medicine, Biophysics}}, publisher = {{Elsevier BV}}, title = {{{Producing deceptive actions in sports: The costs of generating head fakes in basketball}}}, doi = {{10.1016/j.humov.2022.103045}}, volume = {{87}}, year = {{2023}}, } @article{43061, abstract = {{Purpose: The aim of this study was to examine whether cortical activity changes during exercise with increasing cognitive demands in preadolescent children. Method: Twenty healthy children (8.75 [0.91] y) performed one movement game, which was conducted with lower and higher cognitive demands. During a baseline measurement and both exercise conditions, cortical activity was recorded using a 64-channel electroencephalographic system, and heart rate was assessed. Ratings of perceived excertion and perceived cognitive engagement were examined after each condition. To analyze power spectral density in the theta, alpha-1, and alpha-2 frequency bands, an adaptive mixture independent component analysis was used to determine the spatiotemporal sources of cortical activity, and brain components were clustered to identify spatial clusters. Results: One-way repeated-measures analyses of variance revealed significant main effects for condition on theta in the prefrontal cluster, on alpha-1 in the prefrontal, central, bilateral motor, bilateral parieto-occipital, and occipital clusters, and on alpha-2 in the left motor, central, and left parieto-occipital clusters. Compared with the lower cognitive demand exercise, cortical activity was significantly higher in theta power in the prefrontal cluster and in alpha-1 power in the occipital cluster during the higher cognitive demand exercise. Conclusion: The present study shows that exercise complexity seems to influence cortical processing as it increased with increasing cognitive demands.}}, author = {{Becker, Linda and Büchel, Daniel and Lehmann, Tim and Kehne, Miriam and Baumeister, Jochen}}, issn = {{0899-8493}}, journal = {{Pediatric Exercise Science}}, keywords = {{Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine, Pediatrics, Perinatology and Child Health}}, pages = {{1--11}}, publisher = {{Human Kinetics}}, title = {{{Mobile Electroencephalography Reveals Differences in Cortical Processing During Exercises With Lower and Higher Cognitive Demands in Preadolescent Children}}}, doi = {{10.1123/pes.2021-0212}}, year = {{2023}}, } @article{49636, abstract = {{Abstract Purpose Wearables serve to quantify the on-court activity in intermittent sports such as field hockey (FH). Based on objective data, benchmarks can be determined to tailor training intensity and volume. Next to average and accumulated values, the most intense periods (MIPs) during competitive FH matches are of special interest, since these quantify the peak intensities players experience throughout the intermittent matches. The aim of this study was to retrospectively compare peak intensities between training and competition sessions in a male FH team competing in the first german division. Methods Throughout an 8-week in-season period, 372 individual activity datasets (144 datasets from competitive sessions) were recorded using the Polar Team Pro sensor (Kempele, Finland). MIPs were calculated applying a rolling window approach with predefined window length (1–5 min) and calculated for Total distance, High-Intensity-Running distance (> 16 km/h), Sprinting distance (> 20 km/h) and Acceleration load. Significant differences between training and competition MIPs were analysed through non-parametric statistical tests (P < 0.05). Results Analyses revealed higher MIPs during competition for all considered outcomes (P < 0.001). Effect size estimation revealed strongest effects for sprinting distance (d = 1.89 to d = 1.22) and lowest effect sizes for acceleration load (d = 0.92 to d = 0.49). Conclusion The present findings demonstrate that peak intensities during training do not reach those experienced during competitive sessions in a male FH team. Training routines such as manipulations of court-dimensions and team sizes might contribute to this discrepancy. Coaches should compare training and competition intensities to recalibrate training routines to optimize athletes’ preparation for competition. }}, author = {{Büchel, Daniel and Döring, Michael and Baumeister, Jochen}}, issn = {{2096-6709}}, journal = {{Journal of Science in Sport and Exercise}}, keywords = {{Nutrition and Dietetics, Rehabilitation, Orthopedics and Sports Medicine, Physical Therapy, Sports Therapy and Rehabilitation, Physiology}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{A Comparison of the Most Intense Periods (MIPs) During Competitive Matches and Training Over an 8-Week Period in a Male Elite Field Hockey Team}}}, doi = {{10.1007/s42978-023-00261-w}}, year = {{2023}}, } @article{32578, abstract = {{Abstract Background The outcome after ACL reconstruction (ACLR) is in general disappointing with unacceptable number of athletes that do not return to pre-injury level of sports, high re-injury rates, early development of osteoarthritis and shorter careers. Athletes after ACLR have high expectation to return to sports which is in contrast with the current outcomes. The aim of this manuscript is to present an overview of factors that are needed to be incorporated and to personalize the rehabilitation process for an athlete who has undergone an ACLR. Level of evidence 4. }}, author = {{Gokeler, Alli and Grassi, Alberto and Hoogeslag, Roy and van Houten, Albert and Bolling, Caroline and Buckthorpe, Matthew and Norte, Grant and Benjaminse, Anne and Heuvelmans, Pieter and Di Paolo, Stefano and Tak, Igor and Villa, Francesco Della}}, issn = {{2197-1153}}, journal = {{Journal of Experimental Orthopaedics}}, keywords = {{Orthopedics and Sports Medicine}}, number = {{1}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Return to sports after ACL injury 5 years from now: 10 things we must do}}}, doi = {{10.1186/s40634-022-00514-7}}, volume = {{9}}, year = {{2022}}, } @article{32449, author = {{Di Paolo, Stefano and Nijmeijer, Eline and Bragonzoni, Laura and Dingshoff, Evelien and Gokeler, Alli and Benjaminse, Anne}}, issn = {{1746-1391}}, journal = {{European Journal of Sport Science}}, keywords = {{Orthopedics and Sports Medicine, Physical Therapy, Sports Therapy and Rehabilitation, General Medicine}}, pages = {{1--10}}, publisher = {{Informa UK Limited}}, title = {{{Comparing lab and field agility kinematics in young talented female football players: Implications for ACL injury prevention}}}, doi = {{10.1080/17461391.2022.2064771}}, year = {{2022}}, } @article{34478, abstract = {{Abstract Background The outcome after ACL reconstruction (ACLR) is in general disappointing with unacceptable number of athletes that do not return to pre-injury level of sports, high re-injury rates, early development of osteoarthritis and shorter careers. Athletes after ACLR have high expectation to return to sports which is in contrast with the current outcomes. The aim of this manuscript is to present an overview of factors that are needed to be incorporated and to personalize the rehabilitation process for an athlete who has undergone an ACLR. Level of evidence 4. }}, author = {{Gokeler, Alli and Grassi, Alberto and Hoogeslag, Roy and van Houten, Albert and Lehman, Tim and Bolling, Caroline and Buckthorpe, Matthew and Norte, Grant and Benjaminse, Anne and Heuvelmans, Pieter and Di Paolo, Stefano and Tak, Igor and Villa, Francesco Della}}, issn = {{2197-1153}}, journal = {{Journal of Experimental Orthopaedics}}, keywords = {{Orthopedics and Sports Medicine}}, number = {{1}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Return to sports after ACL injury 5 years from now: 10 things we must do}}}, doi = {{10.1186/s40634-022-00514-7}}, volume = {{9}}, year = {{2022}}, } @article{34477, author = {{Gokeler, Alli and Grassi, Alberto and Hoogeslag, Roy and van Houten, Albert and Lehman, Tim and Bolling, Caroline and Buckthorpe, Matthew and Norte, Grant and Benjaminse, Anne and Heuvelmans, Pieter and Di Paolo, Stefano and Tak, Igor and Villa, Francesco Della}}, issn = {{2197-1153}}, journal = {{Journal of Experimental Orthopaedics}}, keywords = {{Orthopedics and Sports Medicine}}, number = {{1}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Correction: Return to sports after ACL injury 5 years from now: 10 things we must do}}}, doi = {{10.1186/s40634-022-00548-x}}, volume = {{9}}, year = {{2022}}, } @article{34475, author = {{Di Paolo, Stefano and Nijmeijer, Eline and Bragonzoni, Laura and Dingshoff, Evelien and Gokeler, Alli and Benjaminse, Anne}}, issn = {{1746-1391}}, journal = {{European Journal of Sport Science}}, keywords = {{Orthopedics and Sports Medicine, Physical Therapy, Sports Therapy and Rehabilitation, General Medicine}}, pages = {{1--10}}, publisher = {{Informa UK Limited}}, title = {{{Comparing lab and field agility kinematics in young talented female football players: Implications for ACL injury prevention}}}, doi = {{10.1080/17461391.2022.2064771}}, year = {{2022}}, } @article{35539, author = {{Lehmann, Tim and Visser, Anton and Havers, Tim and Büchel, Daniel and Baumeister, Jochen}}, issn = {{1530-0315}}, journal = {{Medicine &Science in Sports& Exercise}}, keywords = {{Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine}}, number = {{9S}}, pages = {{565--565}}, publisher = {{Ovid Technologies (Wolters Kluwer Health)}}, title = {{{Surface Instability Modulates Cortical Information Processing In Multi-Joint Compound Movements}}}, doi = {{10.1249/01.mss.0000882152.12078.64}}, volume = {{54}}, year = {{2022}}, } @article{35537, author = {{Büchel, Daniel and Allen, Carlos and Lehmann, Tim and Sandbakk, Øyvind and Baumeister, Jochen}}, issn = {{1530-0315}}, journal = {{Medicine &Science in Sports& Exercise}}, keywords = {{Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine}}, number = {{9S}}, pages = {{262--262}}, publisher = {{Ovid Technologies (Wolters Kluwer Health)}}, title = {{{Changes In Eeg Microstate Patterns Following Exhaustive Treadmill Exercise When Employing Reduced Channel Resolution}}}, doi = {{10.1249/01.mss.0000878300.82239.03}}, volume = {{54}}, year = {{2022}}, } @article{35623, author = {{Gokeler, Alli and Grassi, Alberto and Hoogeslag, Roy and van Houten, Albert and Lehmann, Tim and Bolling, Caroline and Buckthorpe, Matthew and Norte, Grant and Benjaminse, Anne and Heuvelmans, Pieter and Di Paolo, Stefano and Tak, Igor and Villa, Francesco Della}}, issn = {{2197-1153}}, journal = {{Journal of Experimental Orthopaedics}}, keywords = {{Orthopedics and Sports Medicine}}, number = {{1}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Correction: Return to sports after ACL injury 5 years from now: 10 things we must do}}}, doi = {{10.1186/s40634-022-00548-x}}, volume = {{9}}, year = {{2022}}, } @article{35624, author = {{Lehmann, Tim and Visser, Anton and Havers, Tim and Büchel, Daniel and Baumeister, Jochen}}, issn = {{1530-0315}}, journal = {{Medicine & Science in Sports & Exercise}}, keywords = {{Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine}}, number = {{9S}}, pages = {{565--565}}, publisher = {{Ovid Technologies (Wolters Kluwer Health)}}, title = {{{Surface Instability Modulates Cortical Information Processing In Multi-Joint Compound Movements}}}, doi = {{10.1249/01.mss.0000882152.12078.64}}, volume = {{54}}, year = {{2022}}, } @inproceedings{35627, author = {{Büchel, Daniel and Allen, Carlos and Lehmann, Tim and Sandbakk, Øyvind and Baumeister, Jochen}}, booktitle = {{Medicine & Science in Sports & Exercise}}, issn = {{1530-0315}}, keywords = {{Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine}}, number = {{9S}}, pages = {{262--262}}, publisher = {{Ovid Technologies (Wolters Kluwer Health)}}, title = {{{Changes In Eeg Microstate Patterns Following Exhaustive Treadmill Exercise When Employing Reduced Channel Resolution}}}, doi = {{10.1249/01.mss.0000878300.82239.03}}, volume = {{54}}, year = {{2022}}, } @article{45121, abstract = {{Abstract Background The outcome after ACL reconstruction (ACLR) is in general disappointing with unacceptable number of athletes that do not return to pre-injury level of sports, high re-injury rates, early development of osteoarthritis and shorter careers. Athletes after ACLR have high expectation to return to sports which is in contrast with the current outcomes. The aim of this manuscript is to present an overview of factors that are needed to be incorporated and to personalize the rehabilitation process for an athlete who has undergone an ACLR. Level of evidence 4. }}, author = {{Gokeler, Alli and Grassi, Alberto and Hoogeslag, Roy and van Houten, Albert and Lehmann, Tim and Bolling, Caroline and Buckthorpe, Matthew and Norte, Grant and Benjaminse, Anne and Heuvelmans, Pieter and Di Paolo, Stefano and Tak, Igor and Villa, Francesco Della}}, issn = {{2197-1153}}, journal = {{Journal of Experimental Orthopaedics}}, keywords = {{Orthopedics and Sports Medicine}}, number = {{1}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Return to sports after ACL injury 5 years from now: 10 things we must do}}}, doi = {{10.1186/s40634-022-00514-7}}, volume = {{9}}, year = {{2022}}, }