[{"year":"2023","page":"88-99","intvolume":"       149","citation":{"ama":"Sherman DA, Baumeister J, Stock MS, Murray AM, Bazett-Jones DM, Norte GE. Brain activation and single-limb balance following anterior cruciate ligament reconstruction. <i>Clinical Neurophysiology</i>. 2023;149:88-99. doi:<a href=\"https://doi.org/10.1016/j.clinph.2023.02.175\">10.1016/j.clinph.2023.02.175</a>","chicago":"Sherman, David A., Jochen Baumeister, Matt S. Stock, Amanda M. Murray, David M. Bazett-Jones, and Grant E. Norte. “Brain Activation and Single-Limb Balance Following Anterior Cruciate Ligament Reconstruction.” <i>Clinical Neurophysiology</i> 149 (2023): 88–99. <a href=\"https://doi.org/10.1016/j.clinph.2023.02.175\">https://doi.org/10.1016/j.clinph.2023.02.175</a>.","ieee":"D. A. Sherman, J. Baumeister, M. S. Stock, A. M. Murray, D. M. Bazett-Jones, and G. E. Norte, “Brain activation and single-limb balance following anterior cruciate ligament reconstruction,” <i>Clinical Neurophysiology</i>, vol. 149, pp. 88–99, 2023, doi: <a href=\"https://doi.org/10.1016/j.clinph.2023.02.175\">10.1016/j.clinph.2023.02.175</a>.","short":"D.A. Sherman, J. Baumeister, M.S. Stock, A.M. Murray, D.M. Bazett-Jones, G.E. Norte, Clinical Neurophysiology 149 (2023) 88–99.","bibtex":"@article{Sherman_Baumeister_Stock_Murray_Bazett-Jones_Norte_2023, title={Brain activation and single-limb balance following anterior cruciate ligament reconstruction}, volume={149}, DOI={<a href=\"https://doi.org/10.1016/j.clinph.2023.02.175\">10.1016/j.clinph.2023.02.175</a>}, journal={Clinical Neurophysiology}, publisher={Elsevier BV}, author={Sherman, David A. and Baumeister, Jochen and Stock, Matt S. and Murray, Amanda M. and Bazett-Jones, David M. and Norte, Grant E.}, year={2023}, pages={88–99} }","mla":"Sherman, David A., et al. “Brain Activation and Single-Limb Balance Following Anterior Cruciate Ligament Reconstruction.” <i>Clinical Neurophysiology</i>, vol. 149, Elsevier BV, 2023, pp. 88–99, doi:<a href=\"https://doi.org/10.1016/j.clinph.2023.02.175\">10.1016/j.clinph.2023.02.175</a>.","apa":"Sherman, D. A., Baumeister, J., Stock, M. S., Murray, A. M., Bazett-Jones, D. M., &#38; Norte, G. E. (2023). Brain activation and single-limb balance following anterior cruciate ligament reconstruction. <i>Clinical Neurophysiology</i>, <i>149</i>, 88–99. <a href=\"https://doi.org/10.1016/j.clinph.2023.02.175\">https://doi.org/10.1016/j.clinph.2023.02.175</a>"},"publication_identifier":{"issn":["1388-2457"]},"publication_status":"published","title":"Brain activation and single-limb balance following anterior cruciate ligament reconstruction","doi":"10.1016/j.clinph.2023.02.175","date_updated":"2023-05-19T09:34:35Z","publisher":"Elsevier BV","volume":149,"date_created":"2023-05-19T09:33:37Z","author":[{"first_name":"David A.","full_name":"Sherman, David A.","last_name":"Sherman"},{"first_name":"Jochen","last_name":"Baumeister","orcid":"0000-0003-2683-5826","full_name":"Baumeister, Jochen","id":"46"},{"full_name":"Stock, Matt S.","last_name":"Stock","first_name":"Matt S."},{"first_name":"Amanda M.","last_name":"Murray","full_name":"Murray, Amanda M."},{"first_name":"David M.","last_name":"Bazett-Jones","full_name":"Bazett-Jones, David M."},{"first_name":"Grant E.","last_name":"Norte","full_name":"Norte, Grant E."}],"status":"public","publication":"Clinical Neurophysiology","type":"journal_article","keyword":["Physiology (medical)","Neurology (clinical)","Neurology","Sensory Systems"],"language":[{"iso":"eng"}],"_id":"45159","department":[{"_id":"17"}],"user_id":"46"},{"language":[{"iso":"eng"}],"keyword":["Physiology (medical)","Public Health","Environmental and Occupational Health","Orthopedics and Sports Medicine","General Medicine","Public Health","Environmental and Occupational Health","Physiology"],"publication":"European Journal of Applied Physiology","abstract":[{"lang":"eng","text":"<jats:title>Abstract</jats:title><jats:sec>\r\n<jats:title>Purpose</jats:title>\r\n<jats:p>Space flight and bed rest (BR) lead to a rapid decline in exercise capacity. Whey protein plus potassium bicarbonate diet-supplementation (NUTR) could attenuate this effect by improving oxidative metabolism. We evaluated the impact of 21-day BR and NUTR on fatigue resistance of plantar flexor muscles (PF) during repeated shortening contractions, and whether any change was related to altered energy metabolism and muscle oxygenation.</jats:p>\r\n</jats:sec><jats:sec>\r\n<jats:title>Methods</jats:title>\r\n<jats:p>Ten healthy men received a standardized isocaloric diet with (<jats:italic>n</jats:italic> = 5) or without (<jats:italic>n</jats:italic> = 5) NUTR. Eight bouts of 24 concentric plantar flexions (30 s each bout) with 20 s rest between bouts were employed. PF muscle size was assessed by means of peripheral quantitative computed tomography. PF muscle volume was assessed with magnetic resonance imaging. PF muscle force, contraction velocity, power and surface electromyogram signals were recorded during each contraction, as well as energy metabolism (<jats:sup>31</jats:sup>P nuclear magnetic resonance spectroscopy) and oxygenation (near-infrared spectroscopy). Cardiopulmonary parameters were measured during an incremental cycle exercise test.</jats:p>\r\n</jats:sec><jats:sec>\r\n<jats:title>Results</jats:title>\r\n<jats:p>BR caused 10–15% loss of PF volume that was partly recovered 3 days after re-ambulation, as a consequence of fluid redistribution. Unexpectedly, PF fatigue resistance was not affected by BR or NUTR. BR induced a shift in muscle metabolism toward glycolysis and some signs of impaired muscle oxygen extraction. NUTR did not attenuate the BR-induced-shift in energy metabolism.</jats:p>\r\n</jats:sec><jats:sec>\r\n<jats:title>Conclusions</jats:title>\r\n<jats:p>Twenty-one days’ BR did not impair PF fatigue resistance, but the shift to glycolytic metabolism and indications of impaired oxygen extraction may be early signs of developing reduced muscle fatigue resistance.</jats:p>\r\n</jats:sec>"}],"date_created":"2022-09-15T09:30:41Z","publisher":"Springer Science and Business Media LLC","title":"Effects of 21 days of bed rest and whey protein supplementation on plantar flexor muscle fatigue resistance during repeated shortening contractions","issue":"5","year":"2020","user_id":"89838","_id":"33389","extern":"1","type":"journal_article","status":"public","author":[{"first_name":"Alessandra","full_name":"Bosutti, Alessandra","last_name":"Bosutti"},{"last_name":"Mulder","full_name":"Mulder, Edwin","first_name":"Edwin"},{"first_name":"Jochen","last_name":"Zange","full_name":"Zange, Jochen"},{"last_name":"Bühlmeier","full_name":"Bühlmeier, Judith","id":"89838","first_name":"Judith"},{"full_name":"Ganse, Bergita","last_name":"Ganse","first_name":"Bergita"},{"last_name":"Degens","full_name":"Degens, Hans","first_name":"Hans"}],"volume":120,"date_updated":"2022-09-15T09:48:23Z","doi":"10.1007/s00421-020-04333-5","publication_status":"published","publication_identifier":{"issn":["1439-6319","1439-6327"]},"citation":{"ama":"Bosutti A, Mulder E, Zange J, Bühlmeier J, Ganse B, Degens H. Effects of 21 days of bed rest and whey protein supplementation on plantar flexor muscle fatigue resistance during repeated shortening contractions. <i>European Journal of Applied Physiology</i>. 2020;120(5):969-983. doi:<a href=\"https://doi.org/10.1007/s00421-020-04333-5\">10.1007/s00421-020-04333-5</a>","chicago":"Bosutti, Alessandra, Edwin Mulder, Jochen Zange, Judith Bühlmeier, Bergita Ganse, and Hans Degens. “Effects of 21 Days of Bed Rest and Whey Protein Supplementation on Plantar Flexor Muscle Fatigue Resistance during Repeated Shortening Contractions.” <i>European Journal of Applied Physiology</i> 120, no. 5 (2020): 969–83. <a href=\"https://doi.org/10.1007/s00421-020-04333-5\">https://doi.org/10.1007/s00421-020-04333-5</a>.","ieee":"A. Bosutti, E. Mulder, J. Zange, J. Bühlmeier, B. Ganse, and H. Degens, “Effects of 21 days of bed rest and whey protein supplementation on plantar flexor muscle fatigue resistance during repeated shortening contractions,” <i>European Journal of Applied Physiology</i>, vol. 120, no. 5, pp. 969–983, 2020, doi: <a href=\"https://doi.org/10.1007/s00421-020-04333-5\">10.1007/s00421-020-04333-5</a>.","short":"A. Bosutti, E. Mulder, J. Zange, J. Bühlmeier, B. Ganse, H. Degens, European Journal of Applied Physiology 120 (2020) 969–983.","bibtex":"@article{Bosutti_Mulder_Zange_Bühlmeier_Ganse_Degens_2020, title={Effects of 21 days of bed rest and whey protein supplementation on plantar flexor muscle fatigue resistance during repeated shortening contractions}, volume={120}, DOI={<a href=\"https://doi.org/10.1007/s00421-020-04333-5\">10.1007/s00421-020-04333-5</a>}, number={5}, journal={European Journal of Applied Physiology}, publisher={Springer Science and Business Media LLC}, author={Bosutti, Alessandra and Mulder, Edwin and Zange, Jochen and Bühlmeier, Judith and Ganse, Bergita and Degens, Hans}, year={2020}, pages={969–983} }","mla":"Bosutti, Alessandra, et al. “Effects of 21 Days of Bed Rest and Whey Protein Supplementation on Plantar Flexor Muscle Fatigue Resistance during Repeated Shortening Contractions.” <i>European Journal of Applied Physiology</i>, vol. 120, no. 5, Springer Science and Business Media LLC, 2020, pp. 969–83, doi:<a href=\"https://doi.org/10.1007/s00421-020-04333-5\">10.1007/s00421-020-04333-5</a>.","apa":"Bosutti, A., Mulder, E., Zange, J., Bühlmeier, J., Ganse, B., &#38; Degens, H. (2020). Effects of 21 days of bed rest and whey protein supplementation on plantar flexor muscle fatigue resistance during repeated shortening contractions. <i>European Journal of Applied Physiology</i>, <i>120</i>(5), 969–983. <a href=\"https://doi.org/10.1007/s00421-020-04333-5\">https://doi.org/10.1007/s00421-020-04333-5</a>"},"page":"969-983","intvolume":"       120"},{"language":[{"iso":"eng"}],"keyword":["Physiology (medical)","Physiology"],"department":[{"_id":"35"},{"_id":"17"},{"_id":"176"}],"user_id":"33213","_id":"30116","status":"public","publication":"Frontiers in Physiology","type":"journal_article","doi":"10.3389/fphys.2018.01540","title":"Improved Neural Control of Movements Manifests in Expertise-Related Differences in Force Output and Brain Network Dynamics","volume":9,"author":[{"first_name":"Christian Johannes","last_name":"Gölz","orcid":"0000-0003-0536-1481","full_name":"Gölz, Christian Johannes","id":"33725"},{"last_name":"Voelcker-Rehage","full_name":"Voelcker-Rehage, Claudia","first_name":"Claudia"},{"full_name":"Mora, Karin","last_name":"Mora","first_name":"Karin"},{"first_name":"Eva-Maria","last_name":"Reuter","full_name":"Reuter, Eva-Maria"},{"first_name":"Ben","last_name":"Godde","full_name":"Godde, Ben"},{"first_name":"Michael","full_name":"Dellnitz, Michael","last_name":"Dellnitz"},{"first_name":"Claus","id":"48978","full_name":"Reinsberger, Claus","last_name":"Reinsberger"},{"full_name":"Vieluf, Solveig","last_name":"Vieluf","first_name":"Solveig"}],"date_created":"2022-02-25T12:02:21Z","date_updated":"2023-02-06T09:29:40Z","publisher":"Frontiers Media SA","intvolume":"         9","citation":{"ama":"Gölz CJ, Voelcker-Rehage C, Mora K, et al. Improved Neural Control of Movements Manifests in Expertise-Related Differences in Force Output and Brain Network Dynamics. <i>Frontiers in Physiology</i>. 2018;9. doi:<a href=\"https://doi.org/10.3389/fphys.2018.01540\">10.3389/fphys.2018.01540</a>","ieee":"C. J. Gölz <i>et al.</i>, “Improved Neural Control of Movements Manifests in Expertise-Related Differences in Force Output and Brain Network Dynamics,” <i>Frontiers in Physiology</i>, vol. 9, 2018, doi: <a href=\"https://doi.org/10.3389/fphys.2018.01540\">10.3389/fphys.2018.01540</a>.","chicago":"Gölz, Christian Johannes, Claudia Voelcker-Rehage, Karin Mora, Eva-Maria Reuter, Ben Godde, Michael Dellnitz, Claus Reinsberger, and Solveig Vieluf. “Improved Neural Control of Movements Manifests in Expertise-Related Differences in Force Output and Brain Network Dynamics.” <i>Frontiers in Physiology</i> 9 (2018). <a href=\"https://doi.org/10.3389/fphys.2018.01540\">https://doi.org/10.3389/fphys.2018.01540</a>.","apa":"Gölz, C. J., Voelcker-Rehage, C., Mora, K., Reuter, E.-M., Godde, B., Dellnitz, M., Reinsberger, C., &#38; Vieluf, S. (2018). Improved Neural Control of Movements Manifests in Expertise-Related Differences in Force Output and Brain Network Dynamics. <i>Frontiers in Physiology</i>, <i>9</i>. <a href=\"https://doi.org/10.3389/fphys.2018.01540\">https://doi.org/10.3389/fphys.2018.01540</a>","bibtex":"@article{Gölz_Voelcker-Rehage_Mora_Reuter_Godde_Dellnitz_Reinsberger_Vieluf_2018, title={Improved Neural Control of Movements Manifests in Expertise-Related Differences in Force Output and Brain Network Dynamics}, volume={9}, DOI={<a href=\"https://doi.org/10.3389/fphys.2018.01540\">10.3389/fphys.2018.01540</a>}, journal={Frontiers in Physiology}, publisher={Frontiers Media SA}, author={Gölz, Christian Johannes and Voelcker-Rehage, Claudia and Mora, Karin and Reuter, Eva-Maria and Godde, Ben and Dellnitz, Michael and Reinsberger, Claus and Vieluf, Solveig}, year={2018} }","short":"C.J. Gölz, C. Voelcker-Rehage, K. Mora, E.-M. Reuter, B. Godde, M. Dellnitz, C. Reinsberger, S. Vieluf, Frontiers in Physiology 9 (2018).","mla":"Gölz, Christian Johannes, et al. “Improved Neural Control of Movements Manifests in Expertise-Related Differences in Force Output and Brain Network Dynamics.” <i>Frontiers in Physiology</i>, vol. 9, Frontiers Media SA, 2018, doi:<a href=\"https://doi.org/10.3389/fphys.2018.01540\">10.3389/fphys.2018.01540</a>."},"year":"2018","publication_identifier":{"issn":["1664-042X"]},"publication_status":"published"},{"intvolume":"         9","citation":{"ama":"Scheer V, Vieluf S, Cramer L, Jakobsmeyer R, Heitkamp H-C. Changes in Running Economy During a 65-km Ultramarathon. <i>Frontiers in Physiology</i>. 2018;9. doi:<a href=\"https://doi.org/10.3389/fphys.2018.01809\">10.3389/fphys.2018.01809</a>","ieee":"V. Scheer, S. Vieluf, L. Cramer, R. Jakobsmeyer, and H.-C. Heitkamp, “Changes in Running Economy During a 65-km Ultramarathon,” <i>Frontiers in Physiology</i>, vol. 9, 2018, doi: <a href=\"https://doi.org/10.3389/fphys.2018.01809\">10.3389/fphys.2018.01809</a>.","chicago":"Scheer, Volker, Solveig Vieluf, Leoni Cramer, Rasmus Jakobsmeyer, and Hans-Christian Heitkamp. “Changes in Running Economy During a 65-Km Ultramarathon.” <i>Frontiers in Physiology</i> 9 (2018). <a href=\"https://doi.org/10.3389/fphys.2018.01809\">https://doi.org/10.3389/fphys.2018.01809</a>.","short":"V. Scheer, S. Vieluf, L. Cramer, R. Jakobsmeyer, H.-C. Heitkamp, Frontiers in Physiology 9 (2018).","bibtex":"@article{Scheer_Vieluf_Cramer_Jakobsmeyer_Heitkamp_2018, title={Changes in Running Economy During a 65-km Ultramarathon}, volume={9}, DOI={<a href=\"https://doi.org/10.3389/fphys.2018.01809\">10.3389/fphys.2018.01809</a>}, journal={Frontiers in Physiology}, publisher={Frontiers Media SA}, author={Scheer, Volker and Vieluf, Solveig and Cramer, Leoni and Jakobsmeyer, Rasmus and Heitkamp, Hans-Christian}, year={2018} }","mla":"Scheer, Volker, et al. “Changes in Running Economy During a 65-Km Ultramarathon.” <i>Frontiers in Physiology</i>, vol. 9, Frontiers Media SA, 2018, doi:<a href=\"https://doi.org/10.3389/fphys.2018.01809\">10.3389/fphys.2018.01809</a>.","apa":"Scheer, V., Vieluf, S., Cramer, L., Jakobsmeyer, R., &#38; Heitkamp, H.-C. (2018). Changes in Running Economy During a 65-km Ultramarathon. <i>Frontiers in Physiology</i>, <i>9</i>. <a href=\"https://doi.org/10.3389/fphys.2018.01809\">https://doi.org/10.3389/fphys.2018.01809</a>"},"year":"2018","publication_identifier":{"issn":["1664-042X"]},"publication_status":"published","doi":"10.3389/fphys.2018.01809","title":"Changes in Running Economy During a 65-km Ultramarathon","volume":9,"author":[{"last_name":"Scheer","full_name":"Scheer, Volker","first_name":"Volker"},{"last_name":"Vieluf","full_name":"Vieluf, Solveig","first_name":"Solveig"},{"full_name":"Cramer, Leoni","last_name":"Cramer","first_name":"Leoni"},{"orcid":"0000-0002-9385-0834","last_name":"Jakobsmeyer","full_name":"Jakobsmeyer, Rasmus","id":"9583","first_name":"Rasmus"},{"first_name":"Hans-Christian","full_name":"Heitkamp, Hans-Christian","last_name":"Heitkamp"}],"date_created":"2023-02-10T12:48:48Z","date_updated":"2025-08-28T13:38:57Z","publisher":"Frontiers Media SA","status":"public","publication":"Frontiers in Physiology","type":"journal_article","language":[{"iso":"eng"}],"keyword":["Physiology (medical)","Physiology"],"department":[{"_id":"35"},{"_id":"176"}],"user_id":"9583","_id":"41968"},{"citation":{"apa":"Bosutti, A., Salanova, M., Blottner, D., Bühlmeier, J., Mulder, E., Rittweger, J., Yap, M. H., Ganse, B., &#38; Degens, H. (2016). Whey protein with potassium bicarbonate supplement attenuates the reduction in muscle oxidative capacity during 19 days of bed rest. <i>Journal of Applied Physiology</i>, <i>121</i>(4), 838–848. <a href=\"https://doi.org/10.1152/japplphysiol.00936.2015\">https://doi.org/10.1152/japplphysiol.00936.2015</a>","bibtex":"@article{Bosutti_Salanova_Blottner_Bühlmeier_Mulder_Rittweger_Yap_Ganse_Degens_2016, title={Whey protein with potassium bicarbonate supplement attenuates the reduction in muscle oxidative capacity during 19 days of bed rest}, volume={121}, DOI={<a href=\"https://doi.org/10.1152/japplphysiol.00936.2015\">10.1152/japplphysiol.00936.2015</a>}, number={4}, journal={Journal of Applied Physiology}, publisher={American Physiological Society}, author={Bosutti, Alessandra and Salanova, Michele and Blottner, Dieter and Bühlmeier, Judith and Mulder, Edwin and Rittweger, Jörn and Yap, Moi Hoon and Ganse, Bergita and Degens, Hans}, year={2016}, pages={838–848} }","mla":"Bosutti, Alessandra, et al. “Whey Protein with Potassium Bicarbonate Supplement Attenuates the Reduction in Muscle Oxidative Capacity during 19 Days of Bed Rest.” <i>Journal of Applied Physiology</i>, vol. 121, no. 4, American Physiological Society, 2016, pp. 838–48, doi:<a href=\"https://doi.org/10.1152/japplphysiol.00936.2015\">10.1152/japplphysiol.00936.2015</a>.","short":"A. Bosutti, M. Salanova, D. Blottner, J. Bühlmeier, E. Mulder, J. Rittweger, M.H. Yap, B. Ganse, H. Degens, Journal of Applied Physiology 121 (2016) 838–848.","ieee":"A. Bosutti <i>et al.</i>, “Whey protein with potassium bicarbonate supplement attenuates the reduction in muscle oxidative capacity during 19 days of bed rest,” <i>Journal of Applied Physiology</i>, vol. 121, no. 4, pp. 838–848, 2016, doi: <a href=\"https://doi.org/10.1152/japplphysiol.00936.2015\">10.1152/japplphysiol.00936.2015</a>.","chicago":"Bosutti, Alessandra, Michele Salanova, Dieter Blottner, Judith Bühlmeier, Edwin Mulder, Jörn Rittweger, Moi Hoon Yap, Bergita Ganse, and Hans Degens. “Whey Protein with Potassium Bicarbonate Supplement Attenuates the Reduction in Muscle Oxidative Capacity during 19 Days of Bed Rest.” <i>Journal of Applied Physiology</i> 121, no. 4 (2016): 838–48. <a href=\"https://doi.org/10.1152/japplphysiol.00936.2015\">https://doi.org/10.1152/japplphysiol.00936.2015</a>.","ama":"Bosutti A, Salanova M, Blottner D, et al. Whey protein with potassium bicarbonate supplement attenuates the reduction in muscle oxidative capacity during 19 days of bed rest. <i>Journal of Applied Physiology</i>. 2016;121(4):838-848. doi:<a href=\"https://doi.org/10.1152/japplphysiol.00936.2015\">10.1152/japplphysiol.00936.2015</a>"},"intvolume":"       121","page":"838-848","year":"2016","issue":"4","publication_status":"published","publication_identifier":{"issn":["8750-7587","1522-1601"]},"doi":"10.1152/japplphysiol.00936.2015","title":"Whey protein with potassium bicarbonate supplement attenuates the reduction in muscle oxidative capacity during 19 days of bed rest","author":[{"last_name":"Bosutti","full_name":"Bosutti, Alessandra","first_name":"Alessandra"},{"last_name":"Salanova","full_name":"Salanova, Michele","first_name":"Michele"},{"last_name":"Blottner","full_name":"Blottner, Dieter","first_name":"Dieter"},{"first_name":"Judith","full_name":"Bühlmeier, Judith","id":"89838","last_name":"Bühlmeier"},{"last_name":"Mulder","full_name":"Mulder, Edwin","first_name":"Edwin"},{"full_name":"Rittweger, Jörn","last_name":"Rittweger","first_name":"Jörn"},{"last_name":"Yap","full_name":"Yap, Moi Hoon","first_name":"Moi Hoon"},{"first_name":"Bergita","full_name":"Ganse, Bergita","last_name":"Ganse"},{"first_name":"Hans","last_name":"Degens","full_name":"Degens, Hans"}],"date_created":"2022-09-15T09:34:29Z","volume":121,"date_updated":"2022-09-15T09:46:06Z","publisher":"American Physiological Society","status":"public","abstract":[{"text":"<jats:p> The effectiveness of whey protein plus potassium bicarbonate-enriched diet (WP+KHCO<jats:sub>3</jats:sub>) in mitigating disuse-induced changes in muscle fiber oxidative capacity and capillarization was investigated in a 21-day crossover design bed rest study. Ten healthy men (31 ± 6 yr) once received WP+KHCO<jats:sub>3</jats:sub> and once received a standardized isocaloric diet. Muscle biopsies were taken 2 days before and during the 19th day of bed rest (BR) from the soleus (SOL) and vastus lateralis (VL) muscle. Whole-body aerobic power (V̇o<jats:sub>2 max</jats:sub>), muscle fatigue, and isometric strength of knee extensor and plantar flexor muscles were monitored. Muscle fiber types and capillaries were identified by immunohistochemistry. Fiber oxidative capacity was determined as the optical density (OD) at 660 nm of succinate dehydrogenase (SDH)-stained sections. The product of fiber cross-sectional area and SDH-OD (integrated SDH) indicated the maximal oxygen consumption of that fiber. The maximal oxygen consumption supported by a capillary was calculated as the integrated SDH in its supply area. BR reduced isometric strength of knee extensor muscles ( P &lt; 0.05), and the fiber oxidative capacity ( P &lt; 0.001) and V̇o<jats:sub>2 max</jats:sub> ( P = 0.042), but had no significant impact on muscle capillarization or fatigue resistance of thigh muscles. The maximal oxygen consumption supported by a capillary was reduced by 24% in SOL and 16% in VL ( P &lt; 0.001). WP+KHCO<jats:sub>3</jats:sub> attenuated the disuse-induced reduction in fiber oxidative capacity in both muscles ( P &lt; 0.01). In conclusion, following 19 days of bed rest, the decrement in fiber oxidative capacity is proportionally larger than the loss of capillaries. WP+KHCO<jats:sub>3</jats:sub> appears to attenuate disuse-induced reductions in fiber oxidative capacity. </jats:p>","lang":"eng"}],"type":"journal_article","publication":"Journal of Applied Physiology","language":[{"iso":"eng"}],"extern":"1","keyword":["Physiology (medical)","Physiology"],"user_id":"89838","_id":"33394"},{"title":"Musculoskeletal effects of 5 days of bed rest with and without locomotion replacement training","publisher":"Springer Science and Business Media LLC","date_created":"2022-09-15T09:36:45Z","year":"2014","issue":"4","keyword":["Physiology (medical)","Public Health","Environmental and Occupational Health","Orthopedics and Sports Medicine","General Medicine","Public Health","Environmental and Occupational Health","Physiology"],"language":[{"iso":"eng"}],"publication":"European Journal of Applied Physiology","doi":"10.1007/s00421-014-3045-0","date_updated":"2022-09-15T09:55:02Z","volume":115,"author":[{"first_name":"E.","full_name":"Mulder, E.","last_name":"Mulder"},{"full_name":"Clément, G.","last_name":"Clément","first_name":"G."},{"first_name":"D.","full_name":"Linnarsson, D.","last_name":"Linnarsson"},{"full_name":"Paloski, W. H.","last_name":"Paloski","first_name":"W. H."},{"full_name":"Wuyts, F. P.","last_name":"Wuyts","first_name":"F. P."},{"full_name":"Zange, J.","last_name":"Zange","first_name":"J."},{"first_name":"P.","full_name":"Frings-Meuthen, P.","last_name":"Frings-Meuthen"},{"first_name":"B.","full_name":"Johannes, B.","last_name":"Johannes"},{"first_name":"V.","last_name":"Shushakov","full_name":"Shushakov, V."},{"first_name":"M.","last_name":"Grunewald","full_name":"Grunewald, M."},{"last_name":"Maassen","full_name":"Maassen, N.","first_name":"N."},{"first_name":"Judith","full_name":"Bühlmeier, Judith","id":"89838","last_name":"Bühlmeier"},{"full_name":"Rittweger, J.","last_name":"Rittweger","first_name":"J."}],"page":"727-738","intvolume":"       115","citation":{"chicago":"Mulder, E., G. Clément, D. Linnarsson, W. H. Paloski, F. P. Wuyts, J. Zange, P. Frings-Meuthen, et al. “Musculoskeletal Effects of 5 Days of Bed Rest with and without Locomotion Replacement Training.” <i>European Journal of Applied Physiology</i> 115, no. 4 (2014): 727–38. <a href=\"https://doi.org/10.1007/s00421-014-3045-0\">https://doi.org/10.1007/s00421-014-3045-0</a>.","ieee":"E. Mulder <i>et al.</i>, “Musculoskeletal effects of 5 days of bed rest with and without locomotion replacement training,” <i>European Journal of Applied Physiology</i>, vol. 115, no. 4, pp. 727–738, 2014, doi: <a href=\"https://doi.org/10.1007/s00421-014-3045-0\">10.1007/s00421-014-3045-0</a>.","ama":"Mulder E, Clément G, Linnarsson D, et al. Musculoskeletal effects of 5 days of bed rest with and without locomotion replacement training. <i>European Journal of Applied Physiology</i>. 2014;115(4):727-738. doi:<a href=\"https://doi.org/10.1007/s00421-014-3045-0\">10.1007/s00421-014-3045-0</a>","apa":"Mulder, E., Clément, G., Linnarsson, D., Paloski, W. H., Wuyts, F. P., Zange, J., Frings-Meuthen, P., Johannes, B., Shushakov, V., Grunewald, M., Maassen, N., Bühlmeier, J., &#38; Rittweger, J. (2014). Musculoskeletal effects of 5 days of bed rest with and without locomotion replacement training. <i>European Journal of Applied Physiology</i>, <i>115</i>(4), 727–738. <a href=\"https://doi.org/10.1007/s00421-014-3045-0\">https://doi.org/10.1007/s00421-014-3045-0</a>","bibtex":"@article{Mulder_Clément_Linnarsson_Paloski_Wuyts_Zange_Frings-Meuthen_Johannes_Shushakov_Grunewald_et al._2014, title={Musculoskeletal effects of 5 days of bed rest with and without locomotion replacement training}, volume={115}, DOI={<a href=\"https://doi.org/10.1007/s00421-014-3045-0\">10.1007/s00421-014-3045-0</a>}, number={4}, journal={European Journal of Applied Physiology}, publisher={Springer Science and Business Media LLC}, author={Mulder, E. and Clément, G. and Linnarsson, D. and Paloski, W. H. and Wuyts, F. P. and Zange, J. and Frings-Meuthen, P. and Johannes, B. and Shushakov, V. and Grunewald, M. and et al.}, year={2014}, pages={727–738} }","mla":"Mulder, E., et al. “Musculoskeletal Effects of 5 Days of Bed Rest with and without Locomotion Replacement Training.” <i>European Journal of Applied Physiology</i>, vol. 115, no. 4, Springer Science and Business Media LLC, 2014, pp. 727–38, doi:<a href=\"https://doi.org/10.1007/s00421-014-3045-0\">10.1007/s00421-014-3045-0</a>.","short":"E. Mulder, G. Clément, D. Linnarsson, W.H. Paloski, F.P. Wuyts, J. Zange, P. Frings-Meuthen, B. Johannes, V. Shushakov, M. Grunewald, N. Maassen, J. Bühlmeier, J. Rittweger, European Journal of Applied Physiology 115 (2014) 727–738."},"publication_identifier":{"issn":["1439-6319","1439-6327"]},"publication_status":"published","extern":"1","_id":"33398","user_id":"89838","status":"public","type":"journal_article"},{"keyword":["Physiology (medical)","Physiology"],"language":[{"iso":"eng"}],"publication":"Journal of Applied Physiology","abstract":[{"lang":"eng","text":"<jats:p>We examined, in immobilization, the effect of a diet high in sodium chloride (NaCl) on bone markers, nitrogen balance, and acid-base status. Eight healthy male test subjects participated in a 14-day head-down-tilt bed rest (HDBR) study. During the bed rest period they received, in a randomized crossover design, a high (7.7 meq Na<jats:sup>+</jats:sup>/kg body wt per day) and a low (0.7 meq Na<jats:sup>+</jats:sup>/kg body wt per day) NaCl diet. As expected, 24-h excretion of urinary calcium was significantly greater in the high-NaCl-intake HDBR phase than in the low-NaCl-intake HDBR phase ( P &lt; 0.001). High NaCl intake caused a 43–50% greater excretion of the bone resorption markers COOH- (CTX) and NH<jats:sub>2</jats:sub>- (NTX) terminal telopeptide of type I collagen in HDBR than low NaCl in HDBR (CTX/NTX: P &lt; 0.001). Serum concentrations of the bone formation markers bone-specific alkaline phosphatase (bAP) and NH<jats:sub>2</jats:sub>-terminal propeptide of type I procollagen (PINP) were identical in both NaCl intake phases. High NaCl intake led to a more negative nitrogen balance in HDBR ( P &lt; 0.001). Changes were accompanied by increased serum chloride concentration ( P = 0.008), reduced blood bicarbonate ( P = 0.017), and base excess ( P = 0.009) whereas net acid excretion was lower during high than during low NaCl intake in immobilization ( P &lt; 0.001). High NaCl intake during immobilization exacerbates disuse-induced bone and muscle loss by causing further protein wasting and an increase in bone resorption. Changes in the acid-base status, mainly caused by disturbances in electrolyte metabolism, seem to determine NaCl-induced degradation processes.</jats:p>"}],"publisher":"American Physiological Society","date_created":"2022-09-15T09:37:29Z","title":"High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses","issue":"2","year":"2011","_id":"33400","user_id":"89838","extern":"1","type":"journal_article","status":"public","date_updated":"2022-09-15T09:43:45Z","volume":111,"author":[{"first_name":"Petra","full_name":"Frings-Meuthen, Petra","last_name":"Frings-Meuthen"},{"last_name":"Bühlmeier","id":"89838","full_name":"Bühlmeier, Judith","first_name":"Judith"},{"first_name":"Natalie","last_name":"Baecker","full_name":"Baecker, Natalie"},{"first_name":"Peter","full_name":"Stehle, Peter","last_name":"Stehle"},{"first_name":"Rolf","full_name":"Fimmers, Rolf","last_name":"Fimmers"},{"last_name":"May","full_name":"May, Francisca","first_name":"Francisca"},{"last_name":"Kluge","full_name":"Kluge, Goetz","first_name":"Goetz"},{"first_name":"Martina","last_name":"Heer","full_name":"Heer, Martina"}],"doi":"10.1152/japplphysiol.00454.2011","publication_identifier":{"issn":["8750-7587","1522-1601"]},"publication_status":"published","page":"537-542","intvolume":"       111","citation":{"chicago":"Frings-Meuthen, Petra, Judith Bühlmeier, Natalie Baecker, Peter Stehle, Rolf Fimmers, Francisca May, Goetz Kluge, and Martina Heer. “High Sodium Chloride Intake Exacerbates Immobilization-Induced Bone Resorption and Protein Losses.” <i>Journal of Applied Physiology</i> 111, no. 2 (2011): 537–42. <a href=\"https://doi.org/10.1152/japplphysiol.00454.2011\">https://doi.org/10.1152/japplphysiol.00454.2011</a>.","ieee":"P. Frings-Meuthen <i>et al.</i>, “High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses,” <i>Journal of Applied Physiology</i>, vol. 111, no. 2, pp. 537–542, 2011, doi: <a href=\"https://doi.org/10.1152/japplphysiol.00454.2011\">10.1152/japplphysiol.00454.2011</a>.","ama":"Frings-Meuthen P, Bühlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. <i>Journal of Applied Physiology</i>. 2011;111(2):537-542. doi:<a href=\"https://doi.org/10.1152/japplphysiol.00454.2011\">10.1152/japplphysiol.00454.2011</a>","short":"P. Frings-Meuthen, J. Bühlmeier, N. Baecker, P. Stehle, R. Fimmers, F. May, G. Kluge, M. Heer, Journal of Applied Physiology 111 (2011) 537–542.","bibtex":"@article{Frings-Meuthen_Bühlmeier_Baecker_Stehle_Fimmers_May_Kluge_Heer_2011, title={High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses}, volume={111}, DOI={<a href=\"https://doi.org/10.1152/japplphysiol.00454.2011\">10.1152/japplphysiol.00454.2011</a>}, number={2}, journal={Journal of Applied Physiology}, publisher={American Physiological Society}, author={Frings-Meuthen, Petra and Bühlmeier, Judith and Baecker, Natalie and Stehle, Peter and Fimmers, Rolf and May, Francisca and Kluge, Goetz and Heer, Martina}, year={2011}, pages={537–542} }","mla":"Frings-Meuthen, Petra, et al. “High Sodium Chloride Intake Exacerbates Immobilization-Induced Bone Resorption and Protein Losses.” <i>Journal of Applied Physiology</i>, vol. 111, no. 2, American Physiological Society, 2011, pp. 537–42, doi:<a href=\"https://doi.org/10.1152/japplphysiol.00454.2011\">10.1152/japplphysiol.00454.2011</a>.","apa":"Frings-Meuthen, P., Bühlmeier, J., Baecker, N., Stehle, P., Fimmers, R., May, F., Kluge, G., &#38; Heer, M. (2011). High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. <i>Journal of Applied Physiology</i>, <i>111</i>(2), 537–542. <a href=\"https://doi.org/10.1152/japplphysiol.00454.2011\">https://doi.org/10.1152/japplphysiol.00454.2011</a>"}}]