--- _id: '48486' abstract: - lang: eng text: AbstractIntroductionIn Europe, most Internet searches for school‐related tasks are situated at home, where parents can support adolescents. Although the frequency (quantity) of parental support has already been analyzed, a research gap exists concerning the quality of parental support in adolescents' information‐related Internet use. The quality of parental support in the field of homework involvement is known to be a predictor of adolescents' learning motivation and academic achievement, often discussed with regard to self‐determination theory (SDT) in terms of autonomy support, structure, emotional support, and control. These categories were adapted in this study to analyze parents' support in adolescents' Internet searching activities.MethodsUsing a mixed‐methods approach, we combined quantitative questionnaires and qualitative observations to analyze joint information‐related Internet uses. Therefore, 243 parent–adolescent dyads were surveyed and six parent–adolescent dyads were observed by videography in 2019/2020 in Germany. The adolescents were 11 years old, on average.ResultsThe parents rated all qualities higher than the adolescents. Emotional support was rated highest by both groups, whereas structure was rated lowest. Adolescents' and parents' view on parental support differ. The qualitative study revealed parents' often interfering behavior, whereas emotional support was low. Further, the active role of adolescents was highlighted in both quantitative and qualitative data.ConclusionsBy combining quantitative and qualitative approaches, we demonstrated a fruitful application of SDT in analyzing the quality of parental support during adolescents' Internet searches at home and shed light on the co‐construction of joint Internet searches. author: - first_name: Ricarda full_name: Kurock, Ricarda id: '78797' last_name: Kurock - first_name: Jeannine full_name: Teichert, Jeannine id: '83055' last_name: Teichert orcid: 0000-0002-7571-891X - first_name: Dorothee M. full_name: Meister, Dorothee M. id: '346' last_name: Meister orcid: orcid.org/0000-0002-9685-4988 - first_name: Lara full_name: Gerhardts, Lara last_name: Gerhardts - first_name: Heike M. full_name: Buhl, Heike M. id: '27152' last_name: Buhl - first_name: Sabrina full_name: Bonanati, Sabrina last_name: Bonanati citation: ama: Kurock R, Teichert J, Meister DM, Gerhardts L, Buhl HM, Bonanati S. A mixed‐methods study of the quality of parental support during adolescents’ information‐related Internet use as a co‐construction process. Journal of Adolescence. 2024;96(3):566-579. doi:http://dx.doi.org/10.1002/jad.12264 apa: Kurock, R., Teichert, J., Meister, D. M., Gerhardts, L., Buhl, H. M., & Bonanati, S. (2024). A mixed‐methods study of the quality of parental support during adolescents’ information‐related Internet use as a co‐construction process. Journal of Adolescence, 96(3), 566–579. http://dx.doi.org/10.1002/jad.12264 bibtex: '@article{Kurock_Teichert_Meister_Gerhardts_Buhl_Bonanati_2024, title={A mixed‐methods study of the quality of parental support during adolescents’ information‐related Internet use as a co‐construction process}, volume={96}, DOI={http://dx.doi.org/10.1002/jad.12264}, number={3}, journal={Journal of Adolescence}, publisher={Wiley}, author={Kurock, Ricarda and Teichert, Jeannine and Meister, Dorothee M. and Gerhardts, Lara and Buhl, Heike M. and Bonanati, Sabrina}, year={2024}, pages={566–579} }' chicago: 'Kurock, Ricarda, Jeannine Teichert, Dorothee M. Meister, Lara Gerhardts, Heike M. Buhl, and Sabrina Bonanati. “A Mixed‐methods Study of the Quality of Parental Support during Adolescents’ Information‐related Internet Use as a Co‐construction Process.” Journal of Adolescence 96, no. 3 (2024): 566–79. http://dx.doi.org/10.1002/jad.12264.' ieee: 'R. Kurock, J. Teichert, D. M. Meister, L. Gerhardts, H. M. Buhl, and S. Bonanati, “A mixed‐methods study of the quality of parental support during adolescents’ information‐related Internet use as a co‐construction process,” Journal of Adolescence, vol. 96, no. 3, pp. 566–579, 2024, doi: http://dx.doi.org/10.1002/jad.12264.' mla: Kurock, Ricarda, et al. “A Mixed‐methods Study of the Quality of Parental Support during Adolescents’ Information‐related Internet Use as a Co‐construction Process.” Journal of Adolescence, vol. 96, no. 3, Wiley, 2024, pp. 566–79, doi:http://dx.doi.org/10.1002/jad.12264. short: R. Kurock, J. Teichert, D.M. Meister, L. Gerhardts, H.M. Buhl, S. Bonanati, Journal of Adolescence 96 (2024) 566–579. date_created: 2023-10-26T12:01:24Z date_updated: 2025-07-03T09:06:39Z department: - _id: '427' - _id: '137' doi: http://dx.doi.org/10.1002/jad.12264 intvolume: ' 96' issue: '3' keyword: - Psychiatry and Mental health - Developmental and Educational Psychology - Social Psychology - Pediatrics - Perinatology and Child Health language: - iso: eng main_file_link: - open_access: '1' url: https://onlinelibrary.wiley.com/doi/10.1002/jad.12264 oa: '1' page: 566-579 project: - _id: '378' grant_number: 01JD1814A name: 'DigHomE: DigHomE: Digital Home Learning Environment – Gelingensbedingungen elterlicher Unterstützung bei der informationsorientierten Internetnutzung' publication: Journal of Adolescence publication_identifier: issn: - 0140-1971 - 1095-9254 publication_status: published publisher: Wiley quality_controlled: '1' status: public title: A mixed‐methods study of the quality of parental support during adolescents' information‐related Internet use as a co‐construction process type: journal_article user_id: '83055' volume: 96 year: '2024' ... --- _id: '33382' author: - first_name: Raphael full_name: Hirtz, Raphael last_name: Hirtz - first_name: Lars full_name: Libuda, Lars id: '88682' last_name: Libuda orcid: 0000-0003-1603-3133 - first_name: Anke full_name: Hinney, Anke last_name: Hinney - first_name: Manuel full_name: Föcker, Manuel last_name: Föcker - first_name: Judith full_name: Bühlmeier, Judith id: '89838' last_name: Bühlmeier - first_name: Paul-Martin full_name: Holterhus, Paul-Martin last_name: Holterhus - first_name: Alexandra full_name: Kulle, Alexandra last_name: Kulle - first_name: Cordula full_name: Kiewert, Cordula last_name: Kiewert - first_name: Ronny full_name: Kuhnert, Ronny last_name: Kuhnert - first_name: Caroline full_name: Cohrdes, Caroline last_name: Cohrdes - first_name: Triinu full_name: Peters, Triinu last_name: Peters - first_name: Johannes full_name: Hebebrand, Johannes last_name: Hebebrand - first_name: Corinna full_name: Grasemann, Corinna last_name: Grasemann citation: ama: 'Hirtz R, Libuda L, Hinney A, et al. Age at menarche relates to depression in adolescent girls: Comparing a clinical sample to the general pediatric population. Journal of Affective Disorders. 2022;318:103-112. doi:10.1016/j.jad.2022.08.092' apa: 'Hirtz, R., Libuda, L., Hinney, A., Föcker, M., Bühlmeier, J., Holterhus, P.-M., Kulle, A., Kiewert, C., Kuhnert, R., Cohrdes, C., Peters, T., Hebebrand, J., & Grasemann, C. (2022). Age at menarche relates to depression in adolescent girls: Comparing a clinical sample to the general pediatric population. Journal of Affective Disorders, 318, 103–112. https://doi.org/10.1016/j.jad.2022.08.092' bibtex: '@article{Hirtz_Libuda_Hinney_Föcker_Bühlmeier_Holterhus_Kulle_Kiewert_Kuhnert_Cohrdes_et al._2022, title={Age at menarche relates to depression in adolescent girls: Comparing a clinical sample to the general pediatric population}, volume={318}, DOI={10.1016/j.jad.2022.08.092}, journal={Journal of Affective Disorders}, publisher={Elsevier BV}, author={Hirtz, Raphael and Libuda, Lars and Hinney, Anke and Föcker, Manuel and Bühlmeier, Judith and Holterhus, Paul-Martin and Kulle, Alexandra and Kiewert, Cordula and Kuhnert, Ronny and Cohrdes, Caroline and et al.}, year={2022}, pages={103–112} }' chicago: 'Hirtz, Raphael, Lars Libuda, Anke Hinney, Manuel Föcker, Judith Bühlmeier, Paul-Martin Holterhus, Alexandra Kulle, et al. “Age at Menarche Relates to Depression in Adolescent Girls: Comparing a Clinical Sample to the General Pediatric Population.” Journal of Affective Disorders 318 (2022): 103–12. https://doi.org/10.1016/j.jad.2022.08.092.' ieee: 'R. Hirtz et al., “Age at menarche relates to depression in adolescent girls: Comparing a clinical sample to the general pediatric population,” Journal of Affective Disorders, vol. 318, pp. 103–112, 2022, doi: 10.1016/j.jad.2022.08.092.' mla: 'Hirtz, Raphael, et al. “Age at Menarche Relates to Depression in Adolescent Girls: Comparing a Clinical Sample to the General Pediatric Population.” Journal of Affective Disorders, vol. 318, Elsevier BV, 2022, pp. 103–12, doi:10.1016/j.jad.2022.08.092.' short: R. Hirtz, L. Libuda, A. Hinney, M. Föcker, J. Bühlmeier, P.-M. Holterhus, A. Kulle, C. Kiewert, R. Kuhnert, C. Cohrdes, T. Peters, J. Hebebrand, C. Grasemann, Journal of Affective Disorders 318 (2022) 103–112. date_created: 2022-09-15T09:15:58Z date_updated: 2022-09-15T09:48:03Z department: - _id: '17' doi: 10.1016/j.jad.2022.08.092 extern: '1' intvolume: ' 318' keyword: - Psychiatry and Mental health - Clinical Psychology language: - iso: eng page: 103-112 publication: Journal of Affective Disorders publication_identifier: issn: - 0165-0327 publication_status: published publisher: Elsevier BV status: public title: 'Age at menarche relates to depression in adolescent girls: Comparing a clinical sample to the general pediatric population' type: journal_article user_id: '89838' volume: 318 year: '2022' ... --- _id: '32326' abstract: - lang: eng text: AbstractGenetic factors are relevant for both eating disorders and body weight regulation. A recent genome-wide association study (GWAS) for anorexia nervosa (AN) detected eight genome-wide significant chromosomal loci. One of these loci, rs10747478, was also genome-wide and significantly associated with body mass index (BMI). The nearest coding gene is the Polypyrimidine Tract Binding Protein 2 gene (PTBP2). To detect mutations in PTBP2, Sanger sequencing of the coding region was performed in 192 female patients with AN (acute or recovered) and 191 children or adolescents with (extreme) obesity. Twenty-five variants were identified. Twenty-three of these were predicted to be pathogenic or functionally relevant in at least one in silico tool. Two novel synonymous variants (p.Ala77Ala and p.Asp195Asp), one intronic SNP (rs188987764), and the intronic deletion (rs561340981) located in the highly conserved region of PTBP2 may have functional consequences. Ten of 20 genes interacting with PTBP2 were studied for their impact on body weight regulation based on either previous functional studies or GWAS hits for body weight or BMI. In a GWAS for BMI (Pulit et al. 2018), the number of genome-wide significant associations at the PTBP2 locus was different between males (60 variants) and females (two variants, one of these also significant in males). More than 65% of these 61 variants showed differences in the effect size pertaining to BMI between sexes (absolute value of Z-score >2, two-sided p < 0.05). One LD block overlapping 5′UTR and all coding regions of PTBP2 comprises 56 significant variants in males. The analysis based on sex-stratified BMI GWAS summary statistics implies that PTBP2 may have a more pronounced effect on body weight regulation in males than in females. article_number: '241' author: - first_name: Yiran full_name: Zheng, Yiran last_name: Zheng - first_name: Luisa Sophie full_name: Rajcsanyi, Luisa Sophie last_name: Rajcsanyi - first_name: Beate full_name: Herpertz-Dahlmann, Beate last_name: Herpertz-Dahlmann - first_name: Jochen full_name: Seitz, Jochen last_name: Seitz - first_name: Martina full_name: de Zwaan, Martina last_name: de Zwaan - first_name: Wolfgang full_name: Herzog, Wolfgang last_name: Herzog - first_name: Stefan full_name: Ehrlich, Stefan last_name: Ehrlich - first_name: Stephan full_name: Zipfel, Stephan last_name: Zipfel - first_name: Katrin full_name: Giel, Katrin last_name: Giel - first_name: Karin full_name: Egberts, Karin last_name: Egberts - first_name: Roland full_name: Burghardt, Roland last_name: Burghardt - first_name: Manuel full_name: Föcker, Manuel last_name: Föcker - first_name: Saad full_name: Al-Lahham, Saad last_name: Al-Lahham - first_name: Triinu full_name: Peters, Triinu last_name: Peters - first_name: Lars full_name: Libuda, Lars id: '88682' last_name: Libuda orcid: 0000-0003-1603-3133 - first_name: Jochen full_name: Antel, Jochen last_name: Antel - first_name: Johannes full_name: Hebebrand, Johannes last_name: Hebebrand - first_name: Anke full_name: Hinney, Anke last_name: Hinney citation: ama: Zheng Y, Rajcsanyi LS, Herpertz-Dahlmann B, et al. PTBP2 – a gene with relevance for both Anorexia nervosa and body weight regulation. Translational Psychiatry. 2022;12(1). doi:10.1038/s41398-022-02018-5 apa: Zheng, Y., Rajcsanyi, L. S., Herpertz-Dahlmann, B., Seitz, J., de Zwaan, M., Herzog, W., Ehrlich, S., Zipfel, S., Giel, K., Egberts, K., Burghardt, R., Föcker, M., Al-Lahham, S., Peters, T., Libuda, L., Antel, J., Hebebrand, J., & Hinney, A. (2022). PTBP2 – a gene with relevance for both Anorexia nervosa and body weight regulation. Translational Psychiatry, 12(1), Article 241. https://doi.org/10.1038/s41398-022-02018-5 bibtex: '@article{Zheng_Rajcsanyi_Herpertz-Dahlmann_Seitz_de Zwaan_Herzog_Ehrlich_Zipfel_Giel_Egberts_et al._2022, title={PTBP2 – a gene with relevance for both Anorexia nervosa and body weight regulation}, volume={12}, DOI={10.1038/s41398-022-02018-5}, number={1241}, journal={Translational Psychiatry}, publisher={Springer Science and Business Media LLC}, author={Zheng, Yiran and Rajcsanyi, Luisa Sophie and Herpertz-Dahlmann, Beate and Seitz, Jochen and de Zwaan, Martina and Herzog, Wolfgang and Ehrlich, Stefan and Zipfel, Stephan and Giel, Katrin and Egberts, Karin and et al.}, year={2022} }' chicago: Zheng, Yiran, Luisa Sophie Rajcsanyi, Beate Herpertz-Dahlmann, Jochen Seitz, Martina de Zwaan, Wolfgang Herzog, Stefan Ehrlich, et al. “PTBP2 – a Gene with Relevance for Both Anorexia Nervosa and Body Weight Regulation.” Translational Psychiatry 12, no. 1 (2022). https://doi.org/10.1038/s41398-022-02018-5. ieee: 'Y. Zheng et al., “PTBP2 – a gene with relevance for both Anorexia nervosa and body weight regulation,” Translational Psychiatry, vol. 12, no. 1, Art. no. 241, 2022, doi: 10.1038/s41398-022-02018-5.' mla: Zheng, Yiran, et al. “PTBP2 – a Gene with Relevance for Both Anorexia Nervosa and Body Weight Regulation.” Translational Psychiatry, vol. 12, no. 1, 241, Springer Science and Business Media LLC, 2022, doi:10.1038/s41398-022-02018-5. short: Y. Zheng, L.S. Rajcsanyi, B. Herpertz-Dahlmann, J. Seitz, M. de Zwaan, W. Herzog, S. Ehrlich, S. Zipfel, K. Giel, K. Egberts, R. Burghardt, M. Föcker, S. Al-Lahham, T. Peters, L. Libuda, J. Antel, J. Hebebrand, A. Hinney, Translational Psychiatry 12 (2022). date_created: 2022-07-06T15:14:13Z date_updated: 2022-10-26T15:49:24Z department: - _id: '35' doi: 10.1038/s41398-022-02018-5 intvolume: ' 12' issue: '1' keyword: - Biological Psychiatry - Cellular and Molecular Neuroscience - Psychiatry and Mental health language: - iso: eng publication: Translational Psychiatry publication_identifier: issn: - 2158-3188 publication_status: published publisher: Springer Science and Business Media LLC status: public title: PTBP2 – a gene with relevance for both Anorexia nervosa and body weight regulation type: journal_article user_id: '88682' volume: 12 year: '2022' ... --- _id: '32327' abstract: - lang: eng text: 'AbstractThere is preliminary evidence that adrenal steroids other than cortisol may be valuable biomarkers for major depressive disorder (MDD). So far, studies have been conducted in adults only, and conclusions are limited, mainly due to small sample sizes. Therefore, the present study assessed whether adrenal steroids serve as biomarkers for adolescent MDD. In 261 depressed adolescents (170 females) treated at a single psychiatric hospital, serum adrenal steroids (progesterone, 17-hydroxyprogesterone, 21-deoxycortisol, 11-deoxycortisol, cortisol, cortisone, deoxycorticosterone, corticosterone) were determined by liquid chromatography-tandem mass spectrometry. Findings were compared to that of an age- and sex-matched reference cohort (N = 255) by nonparametric analysis of variance. Nonparametric receiver operating characteristics (ROC) analyses were conducted to evaluate the diagnostic performance of single steroids and steroid ratios to classify depression status. Sensitivity analyses considered important confounders of adrenal functioning, and ROC results were verified by cross-validation. Compared to the reference cohort, levels of deoxycorticosterone and 21-deoxycortisol were decreased (P < 0.001). All other glucocorticoid- and mineralocorticoid-related steroids were increased (P < 0.001). The corticosterone to deoxycorticosterone ratio evidenced excellent classification characteristics, especially in females (AUC: 0.957; sensitivity: 0.902; specificity: 0.891). The adrenal steroid metabolome qualifies as a bio-readout reflecting adolescent MDD by a distinct steroid pattern that indicates dysfunction of the hypothalamus–pituitary–adrenal axis. Moreover, the corticosterone to deoxycorticosterone ratio may prospectively qualify to contribute to precision medicine in psychiatry by identifying those patients who might benefit from antiglucocorticoid treatment or those at risk for recurrence when adrenal dysfunction has not resolved.' article_number: '255' author: - first_name: Raphael full_name: Hirtz, Raphael last_name: Hirtz - first_name: Lars full_name: Libuda, Lars id: '88682' last_name: Libuda orcid: 0000-0003-1603-3133 - first_name: Anke full_name: Hinney, Anke last_name: Hinney - first_name: Manuel full_name: Föcker, Manuel last_name: Föcker - first_name: Judith full_name: Bühlmeier, Judith id: '89838' last_name: Bühlmeier - first_name: Paul-Martin full_name: Holterhus, Paul-Martin last_name: Holterhus - first_name: Alexandra full_name: Kulle, Alexandra last_name: Kulle - first_name: Cordula full_name: Kiewert, Cordula last_name: Kiewert - first_name: Berthold P. full_name: Hauffa, Berthold P. last_name: Hauffa - first_name: Johannes full_name: Hebebrand, Johannes last_name: Hebebrand - first_name: Corinna full_name: Grasemann, Corinna last_name: Grasemann citation: ama: 'Hirtz R, Libuda L, Hinney A, et al. The adrenal steroid profile in adolescent depression: a valuable bio-readout? Translational Psychiatry. 2022;12(1). doi:10.1038/s41398-022-01966-2' apa: 'Hirtz, R., Libuda, L., Hinney, A., Föcker, M., Bühlmeier, J., Holterhus, P.-M., Kulle, A., Kiewert, C., Hauffa, B. P., Hebebrand, J., & Grasemann, C. (2022). The adrenal steroid profile in adolescent depression: a valuable bio-readout? Translational Psychiatry, 12(1), Article 255. https://doi.org/10.1038/s41398-022-01966-2' bibtex: '@article{Hirtz_Libuda_Hinney_Föcker_Bühlmeier_Holterhus_Kulle_Kiewert_Hauffa_Hebebrand_et al._2022, title={The adrenal steroid profile in adolescent depression: a valuable bio-readout?}, volume={12}, DOI={10.1038/s41398-022-01966-2}, number={1255}, journal={Translational Psychiatry}, publisher={Springer Science and Business Media LLC}, author={Hirtz, Raphael and Libuda, Lars and Hinney, Anke and Föcker, Manuel and Bühlmeier, Judith and Holterhus, Paul-Martin and Kulle, Alexandra and Kiewert, Cordula and Hauffa, Berthold P. and Hebebrand, Johannes and et al.}, year={2022} }' chicago: 'Hirtz, Raphael, Lars Libuda, Anke Hinney, Manuel Föcker, Judith Bühlmeier, Paul-Martin Holterhus, Alexandra Kulle, et al. “The Adrenal Steroid Profile in Adolescent Depression: A Valuable Bio-Readout?” Translational Psychiatry 12, no. 1 (2022). https://doi.org/10.1038/s41398-022-01966-2.' ieee: 'R. Hirtz et al., “The adrenal steroid profile in adolescent depression: a valuable bio-readout?,” Translational Psychiatry, vol. 12, no. 1, Art. no. 255, 2022, doi: 10.1038/s41398-022-01966-2.' mla: 'Hirtz, Raphael, et al. “The Adrenal Steroid Profile in Adolescent Depression: A Valuable Bio-Readout?” Translational Psychiatry, vol. 12, no. 1, 255, Springer Science and Business Media LLC, 2022, doi:10.1038/s41398-022-01966-2.' short: R. Hirtz, L. Libuda, A. Hinney, M. Föcker, J. Bühlmeier, P.-M. Holterhus, A. Kulle, C. Kiewert, B.P. Hauffa, J. Hebebrand, C. Grasemann, Translational Psychiatry 12 (2022). date_created: 2022-07-06T15:14:39Z date_updated: 2023-01-06T11:48:51Z department: - _id: '35' doi: 10.1038/s41398-022-01966-2 intvolume: ' 12' issue: '1' keyword: - Biological Psychiatry - Cellular and Molecular Neuroscience - Psychiatry and Mental health language: - iso: eng publication: Translational Psychiatry publication_identifier: issn: - 2158-3188 publication_status: published publisher: Springer Science and Business Media LLC status: public title: 'The adrenal steroid profile in adolescent depression: a valuable bio-readout?' type: journal_article user_id: '88682' volume: 12 year: '2022' ... --- _id: '33986' abstract: - lang: eng text: ' Zusammenfassung. Genetische Varianten beeinflussen die Gewichtsregulation und die Entwicklung von Essstörungen. Zunächst haben familienbasierte, sogenannte formalgenetische Studien den erblichen Anteil an der Gewichtsregulation und an der Ätiologie von Essstörungen beleuchtet. In einer Vielzahl von Studien zeigten sich sowohl für die Varianz des Körpergewichts als auch für die Entstehung von Essstörungen Erblichkeitsschätzer (Heritabilitätsraten) von über 50 %. Mit diesem Wissen begab man sich in den 90er-Jahren des letzten Jahrhunderts auf die Suche nach den zugrundeliegenden Genen (genauer: genetischen Varianten), die das Körpergewicht, das Essverhalten oder beide Phänotypen auf Grundlage geteilter Mechanismen beeinflussen. Zunächst wurden Kandidatengenstudien durchgeführt. Dabei untersuchte man auf Grundlage unterschiedlicher, v. a. aber pathophysiologisch plausibler Überlegungen Gene mit hoher Relevanz für die untersuchten Phänotypen. Dieser Ansatz war für Essstörungen nicht sehr erfolgreich, für die Gewichtsregulation konnte eine Handvoll Gene identifiziert werden. Verbunden mit großen methodischen Fortschritten in der genetischen Forschung und v. a. der Etablierung sogenannter genomweiter Assoziationsstudien (GWAS) Anfang der 2000er-Jahre konnten bislang über 1000 Varianten/Genorte detektiert werden, die das Körpergewicht beeinflussen. Für die Essstörung Anorexia nervosa (AN) sind aktuell acht solcher Genorte beschrieben. Diese Ergebnisse, aber auch aktuelle Ansätze zu phänotypübergreifenden Analysen lassen Einblicke in die komplexe Regulation des Körpergewichtes zu und haben zudem unerwartete Pathomechanismen für AN aufgezeigt. ' author: - first_name: Raphael full_name: Hirtz, Raphael last_name: Hirtz - first_name: Yiran full_name: Zheng, Yiran last_name: Zheng - first_name: Luisa S. full_name: Rajcsanyi, Luisa S. last_name: Rajcsanyi - first_name: Lars full_name: Libuda, Lars id: '88682' last_name: Libuda orcid: 0000-0003-1603-3133 - first_name: Jochen full_name: Antel, Jochen last_name: Antel - first_name: Triinu full_name: Peters, Triinu last_name: Peters - first_name: Johannes full_name: Hebebrand, Johannes last_name: Hebebrand - first_name: Anke full_name: Hinney, Anke last_name: Hinney citation: ama: Hirtz R, Zheng Y, Rajcsanyi LS, et al. Ebenen der genetischen Analyse komplexer Phänotypen am Beispiel                    der Anorexia nervosa und der Varianz des Körpergewichts. Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie. 2021;50(3):175-185. doi:10.1024/1422-4917/a000829 apa: Hirtz, R., Zheng, Y., Rajcsanyi, L. S., Libuda, L., Antel, J., Peters, T., Hebebrand, J., & Hinney, A. (2021). Ebenen der genetischen Analyse komplexer Phänotypen am Beispiel                    der Anorexia nervosa und der Varianz des Körpergewichts. Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, 50(3), 175–185. https://doi.org/10.1024/1422-4917/a000829 bibtex: '@article{Hirtz_Zheng_Rajcsanyi_Libuda_Antel_Peters_Hebebrand_Hinney_2021, title={Ebenen der genetischen Analyse komplexer Phänotypen am Beispiel                    der Anorexia nervosa und der Varianz des Körpergewichts}, volume={50}, DOI={10.1024/1422-4917/a000829}, number={3}, journal={Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie}, publisher={Hogrefe Publishing Group}, author={Hirtz, Raphael and Zheng, Yiran and Rajcsanyi, Luisa S. and Libuda, Lars and Antel, Jochen and Peters, Triinu and Hebebrand, Johannes and Hinney, Anke}, year={2021}, pages={175–185} }' chicago: 'Hirtz, Raphael, Yiran Zheng, Luisa S. Rajcsanyi, Lars Libuda, Jochen Antel, Triinu Peters, Johannes Hebebrand, and Anke Hinney. “Ebenen der genetischen Analyse komplexer Phänotypen am Beispiel                    der Anorexia nervosa und der Varianz des Körpergewichts.” Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie 50, no. 3 (2021): 175–85. https://doi.org/10.1024/1422-4917/a000829.' ieee: 'R. Hirtz et al., “Ebenen der genetischen Analyse komplexer Phänotypen am Beispiel                    der Anorexia nervosa und der Varianz des Körpergewichts,” Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, vol. 50, no. 3, pp. 175–185, 2021, doi: 10.1024/1422-4917/a000829.' mla: Hirtz, Raphael, et al. “Ebenen der genetischen Analyse komplexer Phänotypen am Beispiel                    der Anorexia nervosa und der Varianz des Körpergewichts.” Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, vol. 50, no. 3, Hogrefe Publishing Group, 2021, pp. 175–85, doi:10.1024/1422-4917/a000829. short: R. Hirtz, Y. Zheng, L.S. Rajcsanyi, L. Libuda, J. Antel, T. Peters, J. Hebebrand, A. Hinney, Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie 50 (2021) 175–185. date_created: 2022-11-03T11:31:50Z date_updated: 2023-01-11T16:58:49Z department: - _id: '35' doi: 10.1024/1422-4917/a000829 intvolume: ' 50' issue: '3' keyword: - Psychiatry and Mental health - Clinical Psychology - General Medicine - Pediatrics - Perinatology and Child Health language: - iso: ger page: 175-185 publication: Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie publication_identifier: issn: - 1422-4917 - 1664-2880 publication_status: published publisher: Hogrefe Publishing Group status: public title: Ebenen der genetischen Analyse komplexer Phänotypen am Beispiel der Anorexia nervosa und der Varianz des Körpergewichts type: journal_article user_id: '88682' volume: 50 year: '2021' ... --- _id: '32434' abstract: - lang: eng text: Whereas initial findings have already identified cortical patterns accompanying proprioceptive deficiencies in patients after anterior cruciate ligament reconstruction (ACLR), little is known about compensatory sensorimotor mechanisms for re-establishing postural control. Therefore, the aim of the present study was to explore leg dependent patterns of cortical contributions to postural control in patients 6 weeks following ACLR. A total of 12 patients after ACLR (25.1 ± 3.2 years, 178.1 ± 9.7 cm, 77.5 ± 14.4 kg) and another 12 gender, age, and activity matched healthy controls participated in this study. All subjects performed 10 × 30 s. single leg stances on each leg, equipped with 64-channel mobile electroencephalography (EEG). Postural stability was quantified by area of sway and sway velocity. Estimations of the weighted phase lag index were conducted as a cortical measure of functional connectivity. The findings showed significant group × leg interactions for increased functional connectivity in the anterior cruciate ligament (ACL) injured leg, predominantly including fronto−parietal [F(1, 22) = 8.41, p ≤ 0.008, η2 = 0.28], fronto−occipital [F(1, 22) = 4.43, p ≤ 0.047, η2 = 0.17], parieto−motor [F(1, 22) = 10.30, p ≤ 0.004, η2 = 0.32], occipito−motor [F(1, 22) = 5.21, p ≤ 0.032, η2 = 0.19], and occipito−parietal [F(1, 22) = 4.60, p ≤ 0.043, η2 = 0.17] intra−hemispherical connections in the contralateral hemisphere and occipito−motor [F(1, 22) = 7.33, p ≤ 0.013, η2 = 0.25] on the ipsilateral hemisphere to the injured leg. Higher functional connectivity in patients after ACLR, attained by increased emphasis of functional connections incorporating the somatosensory and visual areas, may serve as a compensatory mechanism to control postural stability of the injured leg in the early phase of rehabilitation. These preliminary results may help to develop new neurophysiological assessments for detecting functional deficiencies after ACLR in the future. author: - first_name: Tim full_name: Lehmann, Tim id: '41584' last_name: Lehmann - first_name: Daniel full_name: Büchel, Daniel id: '41088' last_name: Büchel - first_name: Caroline full_name: Mouton, Caroline last_name: Mouton - first_name: Alli full_name: Gokeler, Alli last_name: Gokeler - first_name: Romain full_name: Seil, Romain last_name: Seil - first_name: Jochen full_name: Baumeister, Jochen id: '46' last_name: Baumeister orcid: 0000-0003-2683-5826 citation: ama: Lehmann T, Büchel D, Mouton C, Gokeler A, Seil R, Baumeister J. Functional Cortical Connectivity Related to Postural Control in Patients Six Weeks After Anterior Cruciate Ligament Reconstruction. Frontiers in Human Neuroscience. 2021;15. doi:10.3389/fnhum.2021.655116 apa: Lehmann, T., Büchel, D., Mouton, C., Gokeler, A., Seil, R., & Baumeister, J. (2021). Functional Cortical Connectivity Related to Postural Control in Patients Six Weeks After Anterior Cruciate Ligament Reconstruction. Frontiers in Human Neuroscience, 15. https://doi.org/10.3389/fnhum.2021.655116 bibtex: '@article{Lehmann_Büchel_Mouton_Gokeler_Seil_Baumeister_2021, title={Functional Cortical Connectivity Related to Postural Control in Patients Six Weeks After Anterior Cruciate Ligament Reconstruction}, volume={15}, DOI={10.3389/fnhum.2021.655116}, journal={Frontiers in Human Neuroscience}, publisher={Frontiers Media SA}, author={Lehmann, Tim and Büchel, Daniel and Mouton, Caroline and Gokeler, Alli and Seil, Romain and Baumeister, Jochen}, year={2021} }' chicago: Lehmann, Tim, Daniel Büchel, Caroline Mouton, Alli Gokeler, Romain Seil, and Jochen Baumeister. “Functional Cortical Connectivity Related to Postural Control in Patients Six Weeks After Anterior Cruciate Ligament Reconstruction.” Frontiers in Human Neuroscience 15 (2021). https://doi.org/10.3389/fnhum.2021.655116. ieee: 'T. Lehmann, D. Büchel, C. Mouton, A. Gokeler, R. Seil, and J. Baumeister, “Functional Cortical Connectivity Related to Postural Control in Patients Six Weeks After Anterior Cruciate Ligament Reconstruction,” Frontiers in Human Neuroscience, vol. 15, 2021, doi: 10.3389/fnhum.2021.655116.' mla: Lehmann, Tim, et al. “Functional Cortical Connectivity Related to Postural Control in Patients Six Weeks After Anterior Cruciate Ligament Reconstruction.” Frontiers in Human Neuroscience, vol. 15, Frontiers Media SA, 2021, doi:10.3389/fnhum.2021.655116. short: T. Lehmann, D. Büchel, C. Mouton, A. Gokeler, R. Seil, J. Baumeister, Frontiers in Human Neuroscience 15 (2021). date_created: 2022-07-27T07:47:56Z date_updated: 2023-03-13T15:20:11Z department: - _id: '17' - _id: '172' doi: 10.3389/fnhum.2021.655116 intvolume: ' 15' keyword: - Behavioral Neuroscience - Biological Psychiatry - Psychiatry and Mental health - Neurology - Neuropsychology and Physiological Psychology language: - iso: eng publication: Frontiers in Human Neuroscience publication_identifier: issn: - 1662-5161 publication_status: published publisher: Frontiers Media SA status: public title: Functional Cortical Connectivity Related to Postural Control in Patients Six Weeks After Anterior Cruciate Ligament Reconstruction type: journal_article user_id: '46' volume: 15 year: '2021' ...