--- _id: '61335' abstract: - lang: eng text: Amidines are a ubiquitous class of bioactive compounds found in a wide variety of natural products; thus, efficient strategies for their preparation are in great demand. Herein, a novel protocol is reported for the synthesis of amidines based on PIII/PVO redox catalysis. This two‐step, one‐pot approach involves the activation of amides via PIII/PVO catalyzed in situ formation of imidoyl chloride intermediates which are directly converted upon reaction with amines into the corresponding amidines. Instead of traditionally used toxic and corrosive chloride sources, hexachloroacetone (HCA) is successfully employed as a halide source. The reaction proceeds with low catalyst loading (2 mol%) in BuOAc as the solvent. Under the optimized conditions, 20 amidines are prepared in yields up to 99%. A feasible mechanism is proposed based on experimental results. The synthetic potential of this method is evaluated in the preparation of the tyrosine kinase inhibitor (TKI) Erlotinib. article_number: '202500394' author: - first_name: Viktorija full_name: Medvaric, Viktorija id: '92677' last_name: Medvaric - first_name: Jan full_name: Paradies, Jan id: '53339' last_name: Paradies orcid: 0000-0002-3698-668X - first_name: Thomas full_name: Werner, Thomas id: '89271' last_name: Werner orcid: 0000-0001-9025-3244 citation: ama: Medvaric V, Paradies J, Werner T. Synthesis of Amidines Via P(III)/P(V)=O Redox Catalyzed In Situ Formation of Imidoyl Chlorides From Amides. Advanced Synthesis and Catalysis. Published online 2025. doi:10.1002/adsc.70059 apa: Medvaric, V., Paradies, J., & Werner, T. (2025). Synthesis of Amidines Via P(III)/P(V)=O Redox Catalyzed In Situ Formation of Imidoyl Chlorides From Amides. Advanced Synthesis and Catalysis, Article 202500394. https://doi.org/10.1002/adsc.70059 bibtex: '@article{Medvaric_Paradies_Werner_2025, title={Synthesis of Amidines Via P(III)/P(V)=O Redox Catalyzed In Situ Formation of Imidoyl Chlorides From Amides}, DOI={10.1002/adsc.70059}, number={202500394}, journal={Advanced Synthesis and Catalysis}, publisher={Wiley}, author={Medvaric, Viktorija and Paradies, Jan and Werner, Thomas}, year={2025} }' chicago: Medvaric, Viktorija, Jan Paradies, and Thomas Werner. “Synthesis of Amidines Via P(III)/P(V)=O Redox Catalyzed In Situ Formation of Imidoyl Chlorides From Amides.” Advanced Synthesis and Catalysis, 2025. https://doi.org/10.1002/adsc.70059. ieee: 'V. Medvaric, J. Paradies, and T. Werner, “Synthesis of Amidines Via P(III)/P(V)=O Redox Catalyzed In Situ Formation of Imidoyl Chlorides From Amides,” Advanced Synthesis and Catalysis, Art. no. 202500394, 2025, doi: 10.1002/adsc.70059.' mla: Medvaric, Viktorija, et al. “Synthesis of Amidines Via P(III)/P(V)=O Redox Catalyzed In Situ Formation of Imidoyl Chlorides From Amides.” Advanced Synthesis and Catalysis, 202500394, Wiley, 2025, doi:10.1002/adsc.70059. short: V. Medvaric, J. Paradies, T. Werner, Advanced Synthesis and Catalysis (2025). date_created: 2025-09-17T15:16:49Z date_updated: 2025-11-10T08:44:04Z department: - _id: '2' - _id: '389' doi: 10.1002/adsc.70059 keyword: - T2 - T - CSSD language: - iso: eng publication: Advanced Synthesis and Catalysis publication_identifier: issn: - 1615-4150 - 1615-4169 publication_status: published publisher: Wiley status: public title: Synthesis of Amidines Via P(III)/P(V)=O Redox Catalyzed In Situ Formation of Imidoyl Chlorides From Amides type: journal_article user_id: '89271' year: '2025' ... --- _id: '61336' article_number: jacs.5c06190 author: - first_name: Rundong full_name: Zhou, Rundong last_name: Zhou - first_name: Viktorija full_name: Medvaric, Viktorija id: '92677' last_name: Medvaric - first_name: Thomas full_name: Werner, Thomas id: '89271' last_name: Werner orcid: https://orcid.org/0000-0001-9025-3244 - first_name: Jan full_name: Paradies, Jan id: '53339' last_name: Paradies orcid: 0000-0002-3698-668X citation: ama: 'Zhou R, Medvaric V, Werner T, Paradies J. Metal-Free Reduction of Nitrous Oxide via P^III/P^V═O Cycling: Mechanistic Insights and Catalytic Performance. Journal of the American Chemical Society. Published online 2025. doi:10.1021/jacs.5c06190' apa: 'Zhou, R., Medvaric, V., Werner, T., & Paradies, J. (2025). Metal-Free Reduction of Nitrous Oxide via P^III/P^V═O Cycling: Mechanistic Insights and Catalytic Performance. Journal of the American Chemical Society, Article jacs. 5c06190. https://doi.org/10.1021/jacs.5c06190' bibtex: '@article{Zhou_Medvaric_Werner_Paradies_2025, title={Metal-Free Reduction of Nitrous Oxide via P^III/P^V═O Cycling: Mechanistic Insights and Catalytic Performance}, DOI={10.1021/jacs.5c06190}, number={jacs. 5c06190}, journal={Journal of the American Chemical Society}, publisher={American Chemical Society (ACS)}, author={Zhou, Rundong and Medvaric, Viktorija and Werner, Thomas and Paradies, Jan}, year={2025} }' chicago: 'Zhou, Rundong, Viktorija Medvaric, Thomas Werner, and Jan Paradies. “Metal-Free Reduction of Nitrous Oxide via P^III/P^V═O Cycling: Mechanistic Insights and Catalytic Performance.” Journal of the American Chemical Society, 2025. https://doi.org/10.1021/jacs.5c06190.' ieee: 'R. Zhou, V. Medvaric, T. Werner, and J. Paradies, “Metal-Free Reduction of Nitrous Oxide via P^III/P^V═O Cycling: Mechanistic Insights and Catalytic Performance,” Journal of the American Chemical Society, Art. no. jacs. 5c06190, 2025, doi: 10.1021/jacs.5c06190.' mla: 'Zhou, Rundong, et al. “Metal-Free Reduction of Nitrous Oxide via P^III/P^V═O Cycling: Mechanistic Insights and Catalytic Performance.” Journal of the American Chemical Society, jacs. 5c06190, American Chemical Society (ACS), 2025, doi:10.1021/jacs.5c06190.' short: R. Zhou, V. Medvaric, T. Werner, J. Paradies, Journal of the American Chemical Society (2025). date_created: 2025-09-17T15:18:11Z date_updated: 2025-11-10T08:43:50Z department: - _id: '2' - _id: '389' doi: 10.1021/jacs.5c06190 keyword: - T2 - CSSD language: - iso: eng publication: Journal of the American Chemical Society publication_identifier: issn: - 0002-7863 - 1520-5126 publication_status: published publisher: American Chemical Society (ACS) status: public title: 'Metal-Free Reduction of Nitrous Oxide via P^III/P^V═O Cycling: Mechanistic Insights and Catalytic Performance' type: journal_article user_id: '89271' year: '2025' ... --- _id: '62090' abstract: - lang: eng text: The selective N-formylation and N-methylation of amines with carbon dioxide (CO2) catalyzed by methyltriphenylphosphonium methylcarbonate and tuned by polymethylhydrosiloxane or trimethoxysilane as reducing agents is reported. author: - first_name: Changyue full_name: Ren, Changyue last_name: Ren - first_name: Constanza full_name: Terazzi, Constanza last_name: Terazzi - first_name: Thomas full_name: Werner, Thomas id: '89271' last_name: Werner orcid: 0000-0001-9025-3244 citation: ama: Ren C, Terazzi C, Werner T. Tuneable reduction of CO₂ – organocatalyzed selective formylation and methylation of amines. Green Chemistry. 2024;26(1):439-447. doi:10.1039/d3gc03993e apa: Ren, C., Terazzi, C., & Werner, T. (2024). Tuneable reduction of CO₂ – organocatalyzed selective formylation and methylation of amines. Green Chemistry, 26(1), 439–447. https://doi.org/10.1039/d3gc03993e bibtex: '@article{Ren_Terazzi_Werner_2024, title={Tuneable reduction of CO₂ – organocatalyzed selective formylation and methylation of amines}, volume={26}, DOI={10.1039/d3gc03993e}, number={1}, journal={Green Chemistry}, publisher={Royal Society of Chemistry (RSC)}, author={Ren, Changyue and Terazzi, Constanza and Werner, Thomas}, year={2024}, pages={439–447} }' chicago: 'Ren, Changyue, Constanza Terazzi, and Thomas Werner. “Tuneable Reduction of CO₂ – Organocatalyzed Selective Formylation and Methylation of Amines.” Green Chemistry 26, no. 1 (2024): 439–47. https://doi.org/10.1039/d3gc03993e.' ieee: 'C. Ren, C. Terazzi, and T. Werner, “Tuneable reduction of CO₂ – organocatalyzed selective formylation and methylation of amines,” Green Chemistry, vol. 26, no. 1, pp. 439–447, 2024, doi: 10.1039/d3gc03993e.' mla: Ren, Changyue, et al. “Tuneable Reduction of CO₂ – Organocatalyzed Selective Formylation and Methylation of Amines.” Green Chemistry, vol. 26, no. 1, Royal Society of Chemistry (RSC), 2024, pp. 439–47, doi:10.1039/d3gc03993e. short: C. Ren, C. Terazzi, T. Werner, Green Chemistry 26 (2024) 439–447. date_created: 2025-11-05T15:16:32Z date_updated: 2025-11-10T08:44:44Z department: - _id: '35' - _id: '2' doi: 10.1039/d3gc03993e intvolume: ' 26' issue: '1' keyword: - T1 - T2 - CSSD language: - iso: eng page: 439-447 publication: Green Chemistry publication_identifier: issn: - 1463-9262 - 1463-9270 publication_status: published publisher: Royal Society of Chemistry (RSC) status: public title: Tuneable reduction of CO₂ – organocatalyzed selective formylation and methylation of amines type: journal_article user_id: '89271' volume: 26 year: '2024' ... --- _id: '62091' author: - first_name: Changyue full_name: Ren, Changyue last_name: Ren - first_name: Anke full_name: Spannenberg, Anke last_name: Spannenberg - first_name: Thomas full_name: Werner, Thomas id: '89271' last_name: Werner orcid: 0000-0001-9025-3244 citation: ama: Ren C, Spannenberg A, Werner T. Phosphonium-Salt-Catalyzed N-Methylation and N-Formylation of Amines with CO₂. ACS Sustainable Chemistry & Engineering. 2024;12(29):10969-10977. doi:10.1021/acssuschemeng.4c03464 apa: Ren, C., Spannenberg, A., & Werner, T. (2024). Phosphonium-Salt-Catalyzed N-Methylation and N-Formylation of Amines with CO₂. ACS Sustainable Chemistry & Engineering, 12(29), 10969–10977. https://doi.org/10.1021/acssuschemeng.4c03464 bibtex: '@article{Ren_Spannenberg_Werner_2024, title={Phosphonium-Salt-Catalyzed N-Methylation and N-Formylation of Amines with CO₂}, volume={12}, DOI={10.1021/acssuschemeng.4c03464}, number={29}, journal={ACS Sustainable Chemistry & Engineering}, publisher={American Chemical Society (ACS)}, author={Ren, Changyue and Spannenberg, Anke and Werner, Thomas}, year={2024}, pages={10969–10977} }' chicago: 'Ren, Changyue, Anke Spannenberg, and Thomas Werner. “Phosphonium-Salt-Catalyzed N-Methylation and N-Formylation of Amines with CO₂.” ACS Sustainable Chemistry & Engineering 12, no. 29 (2024): 10969–77. https://doi.org/10.1021/acssuschemeng.4c03464.' ieee: 'C. Ren, A. Spannenberg, and T. Werner, “Phosphonium-Salt-Catalyzed N-Methylation and N-Formylation of Amines with CO₂,” ACS Sustainable Chemistry & Engineering, vol. 12, no. 29, pp. 10969–10977, 2024, doi: 10.1021/acssuschemeng.4c03464.' mla: Ren, Changyue, et al. “Phosphonium-Salt-Catalyzed N-Methylation and N-Formylation of Amines with CO₂.” ACS Sustainable Chemistry & Engineering, vol. 12, no. 29, American Chemical Society (ACS), 2024, pp. 10969–77, doi:10.1021/acssuschemeng.4c03464. short: C. Ren, A. Spannenberg, T. Werner, ACS Sustainable Chemistry & Engineering 12 (2024) 10969–10977. date_created: 2025-11-05T15:17:55Z date_updated: 2025-11-10T08:45:58Z department: - _id: '35' - _id: '2' doi: 10.1021/acssuschemeng.4c03464 intvolume: ' 12' issue: '29' keyword: - T1 - T2 - CSSD language: - iso: eng page: 10969-10977 publication: ACS Sustainable Chemistry & Engineering publication_identifier: issn: - 2168-0485 - 2168-0485 publication_status: published publisher: American Chemical Society (ACS) status: public title: Phosphonium-Salt-Catalyzed N-Methylation and N-Formylation of Amines with CO₂ type: journal_article user_id: '89271' volume: 12 year: '2024' ... --- _id: '62088' author: - first_name: Jan full_name: Tönjes, Jan last_name: Tönjes - first_name: Viktorija full_name: Medvarić, Viktorija last_name: Medvarić - first_name: Thomas full_name: Werner, Thomas last_name: Werner citation: ama: Tönjes J, Medvarić V, Werner T. Synthesis of Trisubstituted Furans from Activated Alkenes by P(III)/P(V) Redox Cycling Catalysis. The Journal of Organic Chemistry. 2024;89(15):10729-10735. doi:10.1021/acs.joc.4c00985 apa: Tönjes, J., Medvarić, V., & Werner, T. (2024). Synthesis of Trisubstituted Furans from Activated Alkenes by P(III)/P(V) Redox Cycling Catalysis. The Journal of Organic Chemistry, 89(15), 10729–10735. https://doi.org/10.1021/acs.joc.4c00985 bibtex: '@article{Tönjes_Medvarić_Werner_2024, title={Synthesis of Trisubstituted Furans from Activated Alkenes by P(III)/P(V) Redox Cycling Catalysis}, volume={89}, DOI={10.1021/acs.joc.4c00985}, number={15}, journal={The Journal of Organic Chemistry}, publisher={American Chemical Society (ACS)}, author={Tönjes, Jan and Medvarić, Viktorija and Werner, Thomas}, year={2024}, pages={10729–10735} }' chicago: 'Tönjes, Jan, Viktorija Medvarić, and Thomas Werner. “Synthesis of Trisubstituted Furans from Activated Alkenes by P(III)/P(V) Redox Cycling Catalysis.” The Journal of Organic Chemistry 89, no. 15 (2024): 10729–35. https://doi.org/10.1021/acs.joc.4c00985.' ieee: 'J. Tönjes, V. Medvarić, and T. Werner, “Synthesis of Trisubstituted Furans from Activated Alkenes by P(III)/P(V) Redox Cycling Catalysis,” The Journal of Organic Chemistry, vol. 89, no. 15, pp. 10729–10735, 2024, doi: 10.1021/acs.joc.4c00985.' mla: Tönjes, Jan, et al. “Synthesis of Trisubstituted Furans from Activated Alkenes by P(III)/P(V) Redox Cycling Catalysis.” The Journal of Organic Chemistry, vol. 89, no. 15, American Chemical Society (ACS), 2024, pp. 10729–35, doi:10.1021/acs.joc.4c00985. short: J. Tönjes, V. Medvarić, T. Werner, The Journal of Organic Chemistry 89 (2024) 10729–10735. date_created: 2025-11-05T15:12:46Z date_updated: 2025-11-10T08:45:17Z department: - _id: '35' - _id: '2' doi: 10.1021/acs.joc.4c00985 intvolume: ' 89' issue: '15' keyword: - T2 - CSSD language: - iso: eng page: 10729-10735 publication: The Journal of Organic Chemistry publication_identifier: issn: - 0022-3263 - 1520-6904 publication_status: published publisher: American Chemical Society (ACS) status: public title: Synthesis of Trisubstituted Furans from Activated Alkenes by P(III)/P(V) Redox Cycling Catalysis type: journal_article user_id: '89271' volume: 89 year: '2024' ... --- _id: '62095' author: - first_name: Jan full_name: Tönjes, Jan last_name: Tönjes - first_name: Lukas full_name: Kell, Lukas last_name: Kell - first_name: Thomas full_name: Werner, Thomas id: '89271' last_name: Werner orcid: 0000-0001-9025-3244 citation: ama: Tönjes J, Kell L, Werner T. Organocatalytic Stereospecific Appel Reaction. Organic Letters. 2023;25(51):9114-9118. doi:10.1021/acs.orglett.3c03463 apa: Tönjes, J., Kell, L., & Werner, T. (2023). Organocatalytic Stereospecific Appel Reaction. Organic Letters, 25(51), 9114–9118. https://doi.org/10.1021/acs.orglett.3c03463 bibtex: '@article{Tönjes_Kell_Werner_2023, title={Organocatalytic Stereospecific Appel Reaction}, volume={25}, DOI={10.1021/acs.orglett.3c03463}, number={51}, journal={Organic Letters}, publisher={American Chemical Society (ACS)}, author={Tönjes, Jan and Kell, Lukas and Werner, Thomas}, year={2023}, pages={9114–9118} }' chicago: 'Tönjes, Jan, Lukas Kell, and Thomas Werner. “Organocatalytic Stereospecific Appel Reaction.” Organic Letters 25, no. 51 (2023): 9114–18. https://doi.org/10.1021/acs.orglett.3c03463.' ieee: 'J. Tönjes, L. Kell, and T. Werner, “Organocatalytic Stereospecific Appel Reaction,” Organic Letters, vol. 25, no. 51, pp. 9114–9118, 2023, doi: 10.1021/acs.orglett.3c03463.' mla: Tönjes, Jan, et al. “Organocatalytic Stereospecific Appel Reaction.” Organic Letters, vol. 25, no. 51, American Chemical Society (ACS), 2023, pp. 9114–18, doi:10.1021/acs.orglett.3c03463. short: J. Tönjes, L. Kell, T. Werner, Organic Letters 25 (2023) 9114–9118. date_created: 2025-11-05T15:22:44Z date_updated: 2025-11-10T08:46:39Z department: - _id: '35' - _id: '2' doi: 10.1021/acs.orglett.3c03463 intvolume: ' 25' issue: '51' keyword: - T2 - CSSD language: - iso: eng page: 9114-9118 publication: Organic Letters publication_identifier: issn: - 1523-7060 - 1523-7052 publication_status: published publisher: American Chemical Society (ACS) status: public title: Organocatalytic Stereospecific Appel Reaction type: journal_article user_id: '89271' volume: 25 year: '2023' ... --- _id: '37940' author: - first_name: Changyue full_name: Ren, Changyue last_name: Ren - first_name: Anke full_name: Spannenberg, Anke last_name: Spannenberg - first_name: Thomas full_name: Werner, Thomas id: '89271' last_name: Werner orcid: 0000-0001-9025-3244 citation: ama: Ren C, Spannenberg A, Werner T. Synthesis of Bifunctional Phosphonium Salts Bearing Perfluorinated Side Chains and Their Application in the Synthesis of Cyclic Carbonates from Epoxides and CO ₂. Asian Journal of Organic Chemistry. 2022;11(9). doi:10.1002/ajoc.202200156 apa: Ren, C., Spannenberg, A., & Werner, T. (2022). Synthesis of Bifunctional Phosphonium Salts Bearing Perfluorinated Side Chains and Their Application in the Synthesis of Cyclic Carbonates from Epoxides and CO ₂. Asian Journal of Organic Chemistry, 11(9). https://doi.org/10.1002/ajoc.202200156 bibtex: '@article{Ren_Spannenberg_Werner_2022, title={Synthesis of Bifunctional Phosphonium Salts Bearing Perfluorinated Side Chains and Their Application in the Synthesis of Cyclic Carbonates from Epoxides and CO ₂}, volume={11}, DOI={10.1002/ajoc.202200156}, number={9}, journal={Asian Journal of Organic Chemistry}, publisher={Wiley}, author={Ren, Changyue and Spannenberg, Anke and Werner, Thomas}, year={2022} }' chicago: Ren, Changyue, Anke Spannenberg, and Thomas Werner. “Synthesis of Bifunctional Phosphonium Salts Bearing Perfluorinated Side Chains and Their Application in the Synthesis of Cyclic Carbonates from Epoxides and CO ₂.” Asian Journal of Organic Chemistry 11, no. 9 (2022). https://doi.org/10.1002/ajoc.202200156. ieee: 'C. Ren, A. Spannenberg, and T. Werner, “Synthesis of Bifunctional Phosphonium Salts Bearing Perfluorinated Side Chains and Their Application in the Synthesis of Cyclic Carbonates from Epoxides and CO ₂,” Asian Journal of Organic Chemistry, vol. 11, no. 9, 2022, doi: 10.1002/ajoc.202200156.' mla: Ren, Changyue, et al. “Synthesis of Bifunctional Phosphonium Salts Bearing Perfluorinated Side Chains and Their Application in the Synthesis of Cyclic Carbonates from Epoxides and CO ₂.” Asian Journal of Organic Chemistry, vol. 11, no. 9, Wiley, 2022, doi:10.1002/ajoc.202200156. short: C. Ren, A. Spannenberg, T. Werner, Asian Journal of Organic Chemistry 11 (2022). date_created: 2023-01-22T20:19:21Z date_updated: 2025-11-10T08:47:20Z department: - _id: '35' - _id: '2' - _id: '657' doi: 10.1002/ajoc.202200156 intvolume: ' 11' issue: '9' keyword: - T1 - T2 - CSSD language: - iso: eng publication: Asian Journal of Organic Chemistry publication_identifier: issn: - 2193-5807 - 2193-5815 publication_status: published publisher: Wiley status: public title: Synthesis of Bifunctional Phosphonium Salts Bearing Perfluorinated Side Chains and Their Application in the Synthesis of Cyclic Carbonates from Epoxides and CO ₂ type: journal_article user_id: '89271' volume: 11 year: '2022' ... --- _id: '37946' abstract: - lang: eng text: AbstractThe facile synthesis of highly functionalized building blocks with potential biological activity is of great interest to medicinal chemistry. The benzoxepinone core structures commonly exhibit biological activity. Thus, a short and efficient synthetic route towards benzoxepine containing scaffold, which enables late stage modification was developed. Namely, base-free catalytic Wittig reactions enabled the synthesis of bromobenzoxepinones from readily available starting materials. Subsequent, Suzuki–Miyaura and Stille reactions proved to be suitable methods to access a variety of benzoxepinone diaryl derivatives by late stage modification in only three steps. This three-step reaction sequence is suitable for high throughput applications and gives facile access to highly complex molecular structures, which are suitable for further functionalization. The antiproliferative properties of selected arylbenzoxepinones were tested in vitro on monolayer tumor cell line A549. Notably, in this initial screening, these compounds were found to be active in the micromolar range. author: - first_name: Thomas full_name: Werner, Thomas id: '89271' last_name: Werner orcid: 0000-0001-9025-3244 - first_name: Aiga full_name: Grandane, Aiga last_name: Grandane - first_name: Linda full_name: Pudnika, Linda last_name: Pudnika - first_name: Ilona full_name: Domraceva, Ilona last_name: Domraceva - first_name: Raivis full_name: Zalubovskis, Raivis last_name: Zalubovskis citation: ama: Werner T, Grandane A, Pudnika L, Domraceva I, Zalubovskis R. Base-Free Catalytic Wittig-/Cross-Coupling Reaction Sequence as Short Synthetic Strategy for the Preparation of Highly Functionalized Arylbenzoxepinones. Synthesis. 2021;53(19):3545-3554. doi:10.1055/a-1509-6078 apa: Werner, T., Grandane, A., Pudnika, L., Domraceva, I., & Zalubovskis, R. (2021). Base-Free Catalytic Wittig-/Cross-Coupling Reaction Sequence as Short Synthetic Strategy for the Preparation of Highly Functionalized Arylbenzoxepinones. Synthesis, 53(19), 3545–3554. https://doi.org/10.1055/a-1509-6078 bibtex: '@article{Werner_Grandane_Pudnika_Domraceva_Zalubovskis_2021, title={Base-Free Catalytic Wittig-/Cross-Coupling Reaction Sequence as Short Synthetic Strategy for the Preparation of Highly Functionalized Arylbenzoxepinones}, volume={53}, DOI={10.1055/a-1509-6078}, number={19}, journal={Synthesis}, publisher={Georg Thieme Verlag KG}, author={Werner, Thomas and Grandane, Aiga and Pudnika, Linda and Domraceva, Ilona and Zalubovskis, Raivis}, year={2021}, pages={3545–3554} }' chicago: 'Werner, Thomas, Aiga Grandane, Linda Pudnika, Ilona Domraceva, and Raivis Zalubovskis. “Base-Free Catalytic Wittig-/Cross-Coupling Reaction Sequence as Short Synthetic Strategy for the Preparation of Highly Functionalized Arylbenzoxepinones.” Synthesis 53, no. 19 (2021): 3545–54. https://doi.org/10.1055/a-1509-6078.' ieee: 'T. Werner, A. Grandane, L. Pudnika, I. Domraceva, and R. Zalubovskis, “Base-Free Catalytic Wittig-/Cross-Coupling Reaction Sequence as Short Synthetic Strategy for the Preparation of Highly Functionalized Arylbenzoxepinones,” Synthesis, vol. 53, no. 19, pp. 3545–3554, 2021, doi: 10.1055/a-1509-6078.' mla: Werner, Thomas, et al. “Base-Free Catalytic Wittig-/Cross-Coupling Reaction Sequence as Short Synthetic Strategy for the Preparation of Highly Functionalized Arylbenzoxepinones.” Synthesis, vol. 53, no. 19, Georg Thieme Verlag KG, 2021, pp. 3545–54, doi:10.1055/a-1509-6078. short: T. Werner, A. Grandane, L. Pudnika, I. Domraceva, R. Zalubovskis, Synthesis 53 (2021) 3545–3554. date_created: 2023-01-22T20:27:34Z date_updated: 2025-11-10T08:47:47Z department: - _id: '35' - _id: '2' - _id: '657' doi: 10.1055/a-1509-6078 intvolume: ' 53' issue: '19' keyword: - T2 - T4 - CSSD language: - iso: eng page: 3545-3554 publication: Synthesis publication_identifier: issn: - 0039-7881 - 1437-210X publication_status: published publisher: Georg Thieme Verlag KG status: public title: Base-Free Catalytic Wittig-/Cross-Coupling Reaction Sequence as Short Synthetic Strategy for the Preparation of Highly Functionalized Arylbenzoxepinones type: journal_article user_id: '89271' volume: 53 year: '2021' ... --- _id: '37945' abstract: - lang: eng text:

PMHS proved to be a suitable terminal reductant for P(iii)/P(v) redox cycling with a methyl-substituted phosphetane as catalyst and BuOAc as solvent. The formation of water by silanol condensation was identified as main pathway of siloxane formation.

author: - first_name: Jan full_name: Tönjes, Jan last_name: Tönjes - first_name: Lars full_name: Longwitz, Lars last_name: Longwitz - first_name: Thomas full_name: Werner, Thomas id: '89271' last_name: Werner orcid: 0000-0001-9025-3244 citation: ama: Tönjes J, Longwitz L, Werner T. Poly(methylhydrosiloxane) as a reductant in the catalytic base-free Wittig reaction. Green Chemistry. 2021;23(13):4852-4857. doi:10.1039/d1gc00953b apa: Tönjes, J., Longwitz, L., & Werner, T. (2021). Poly(methylhydrosiloxane) as a reductant in the catalytic base-free Wittig reaction. Green Chemistry, 23(13), 4852–4857. https://doi.org/10.1039/d1gc00953b bibtex: '@article{Tönjes_Longwitz_Werner_2021, title={Poly(methylhydrosiloxane) as a reductant in the catalytic base-free Wittig reaction}, volume={23}, DOI={10.1039/d1gc00953b}, number={13}, journal={Green Chemistry}, publisher={Royal Society of Chemistry (RSC)}, author={Tönjes, Jan and Longwitz, Lars and Werner, Thomas}, year={2021}, pages={4852–4857} }' chicago: 'Tönjes, Jan, Lars Longwitz, and Thomas Werner. “Poly(Methylhydrosiloxane) as a Reductant in the Catalytic Base-Free Wittig Reaction.” Green Chemistry 23, no. 13 (2021): 4852–57. https://doi.org/10.1039/d1gc00953b.' ieee: 'J. Tönjes, L. Longwitz, and T. Werner, “Poly(methylhydrosiloxane) as a reductant in the catalytic base-free Wittig reaction,” Green Chemistry, vol. 23, no. 13, pp. 4852–4857, 2021, doi: 10.1039/d1gc00953b.' mla: Tönjes, Jan, et al. “Poly(Methylhydrosiloxane) as a Reductant in the Catalytic Base-Free Wittig Reaction.” Green Chemistry, vol. 23, no. 13, Royal Society of Chemistry (RSC), 2021, pp. 4852–57, doi:10.1039/d1gc00953b. short: J. Tönjes, L. Longwitz, T. Werner, Green Chemistry 23 (2021) 4852–4857. date_created: 2023-01-22T20:25:13Z date_updated: 2025-11-10T08:48:01Z department: - _id: '35' - _id: '2' - _id: '657' doi: 10.1039/d1gc00953b intvolume: ' 23' issue: '13' keyword: - T2 - CSSD language: - iso: eng page: 4852-4857 publication: Green Chemistry publication_identifier: issn: - 1463-9262 - 1463-9270 publication_status: published publisher: Royal Society of Chemistry (RSC) status: public title: Poly(methylhydrosiloxane) as a reductant in the catalytic base-free Wittig reaction type: journal_article user_id: '89271' volume: 23 year: '2021' ... --- _id: '62101' abstract: - lang: eng text: AbstractThe carbon–carbon double bond of unsaturated carbonyl compounds was readily reduced by using a phosphetane oxide catalyst in the presence of a simple organosilane as the terminal reductant and water as the hydrogen source. Quantitative hydrogenation was observed when 1.0 mol % of a methyl‐substituted phosphetane oxide was employed as the catalyst. The procedure is highly selective towards activated double bonds, tolerating a variety of functional groups that are usually prone to reduction. In total, 25 alkenes and two alkynes were hydrogenated to the corresponding alkanes in excellent yields of up to 99 %. Notably, less active poly(methylhydrosiloxane) could also be utilized as the terminal reductant. Mechanistic investigations revealed the phosphane as the catalyst resting state and a protonation/deprotonation sequence as the crucial step in the catalytic cycle. author: - first_name: Lars full_name: Longwitz, Lars last_name: Longwitz - first_name: Thomas full_name: Werner, Thomas id: '89271' last_name: Werner orcid: 0000-0001-9025-3244 citation: ama: Longwitz L, Werner T. Reduction of Activated Alkenes by P^III/P^V Redox Cycling Catalysis. Angewandte Chemie. 2020;132(7):2782-2785. doi:10.1002/ange.201912991 apa: Longwitz, L., & Werner, T. (2020). Reduction of Activated Alkenes by P^III/P^V Redox Cycling Catalysis. Angewandte Chemie, 132(7), 2782–2785. https://doi.org/10.1002/ange.201912991 bibtex: '@article{Longwitz_Werner_2020, title={Reduction of Activated Alkenes by P^III/P^V Redox Cycling Catalysis}, volume={132}, DOI={10.1002/ange.201912991}, number={7}, journal={Angewandte Chemie}, publisher={Wiley}, author={Longwitz, Lars and Werner, Thomas}, year={2020}, pages={2782–2785} }' chicago: 'Longwitz, Lars, and Thomas Werner. “Reduction of Activated Alkenes by P^III/P^V Redox Cycling Catalysis.” Angewandte Chemie 132, no. 7 (2020): 2782–85. https://doi.org/10.1002/ange.201912991.' ieee: 'L. Longwitz and T. Werner, “Reduction of Activated Alkenes by P^III/P^V Redox Cycling Catalysis,” Angewandte Chemie, vol. 132, no. 7, pp. 2782–2785, 2020, doi: 10.1002/ange.201912991.' mla: Longwitz, Lars, and Thomas Werner. “Reduction of Activated Alkenes by P^III/P^V Redox Cycling Catalysis.” Angewandte Chemie, vol. 132, no. 7, Wiley, 2020, pp. 2782–85, doi:10.1002/ange.201912991. short: L. Longwitz, T. Werner, Angewandte Chemie 132 (2020) 2782–2785. date_created: 2025-11-05T15:39:06Z date_updated: 2025-11-10T08:11:23Z department: - _id: '35' - _id: '2' doi: 10.1002/ange.201912991 intvolume: ' 132' issue: '7' keyword: - T2 - T4 language: - iso: eng page: 2782-2785 publication: Angewandte Chemie publication_identifier: issn: - 0044-8249 - 1521-3757 publication_status: published publisher: Wiley status: public title: Reduction of Activated Alkenes by P^III/P^V Redox Cycling Catalysis type: journal_article user_id: '89271' volume: 132 year: '2020' ... --- _id: '62102' abstract: - lang: eng text: AbstractThe carbon–carbon double bond of unsaturated carbonyl compounds was readily reduced by using a phosphetane oxide catalyst in the presence of a simple organosilane as the terminal reductant and water as the hydrogen source. Quantitative hydrogenation was observed when 1.0 mol % of a methyl‐substituted phosphetane oxide was employed as the catalyst. The procedure is highly selective towards activated double bonds, tolerating a variety of functional groups that are usually prone to reduction. In total, 25 alkenes and two alkynes were hydrogenated to the corresponding alkanes in excellent yields of up to 99 %. Notably, less active poly(methylhydrosiloxane) could also be utilized as the terminal reductant. Mechanistic investigations revealed the phosphane as the catalyst resting state and a protonation/deprotonation sequence as the crucial step in the catalytic cycle. author: - first_name: Lars full_name: Longwitz, Lars last_name: Longwitz - first_name: Thomas full_name: Werner, Thomas id: '89271' last_name: Werner orcid: 0000-0001-9025-3244 citation: ama: Longwitz L, Werner T. Reduction of Activated Alkenes by P^III/P^V Redox Cycling Catalysis. Angewandte Chemie International Edition. 2020;59(7):2760-2763. doi:10.1002/anie.201912991 apa: Longwitz, L., & Werner, T. (2020). Reduction of Activated Alkenes by P^III/P^V Redox Cycling Catalysis. Angewandte Chemie International Edition, 59(7), 2760–2763. https://doi.org/10.1002/anie.201912991 bibtex: '@article{Longwitz_Werner_2020, title={Reduction of Activated Alkenes by P^III/P^V Redox Cycling Catalysis}, volume={59}, DOI={10.1002/anie.201912991}, number={7}, journal={Angewandte Chemie International Edition}, publisher={Wiley}, author={Longwitz, Lars and Werner, Thomas}, year={2020}, pages={2760–2763} }' chicago: 'Longwitz, Lars, and Thomas Werner. “Reduction of Activated Alkenes by P^III/P^V Redox Cycling Catalysis.” Angewandte Chemie International Edition 59, no. 7 (2020): 2760–63. https://doi.org/10.1002/anie.201912991.' ieee: 'L. Longwitz and T. Werner, “Reduction of Activated Alkenes by P^III/P^V Redox Cycling Catalysis,” Angewandte Chemie International Edition, vol. 59, no. 7, pp. 2760–2763, 2020, doi: 10.1002/anie.201912991.' mla: Longwitz, Lars, and Thomas Werner. “Reduction of Activated Alkenes by P^III/P^V Redox Cycling Catalysis.” Angewandte Chemie International Edition, vol. 59, no. 7, Wiley, 2020, pp. 2760–63, doi:10.1002/anie.201912991. short: L. Longwitz, T. Werner, Angewandte Chemie International Edition 59 (2020) 2760–2763. date_created: 2025-11-05T15:39:56Z date_updated: 2025-11-10T08:49:52Z department: - _id: '35' - _id: '2' doi: 10.1002/anie.201912991 intvolume: ' 59' issue: '7' keyword: - T2 - T4 - CSSD language: - iso: eng page: 2760-2763 publication: Angewandte Chemie International Edition publication_identifier: issn: - 1433-7851 - 1521-3773 publication_status: published publisher: Wiley status: public title: Reduction of Activated Alkenes by P^III/P^V Redox Cycling Catalysis type: journal_article user_id: '89271' volume: 59 year: '2020' ... --- _id: '37953' author: - first_name: Yuya full_name: Hu, Yuya last_name: Hu - first_name: Sandra full_name: Peglow, Sandra last_name: Peglow - first_name: Lars full_name: Longwitz, Lars last_name: Longwitz - first_name: Marcus full_name: Frank, Marcus last_name: Frank - first_name: Jan Dirk full_name: Epping, Jan Dirk last_name: Epping - first_name: Volker full_name: Brüser, Volker last_name: Brüser - first_name: Thomas full_name: Werner, Thomas id: '89271' last_name: Werner orcid: 0000-0001-9025-3244 citation: ama: Hu Y, Peglow S, Longwitz L, et al. Plasma‐Assisted Immobilization of a Phosphonium Salt and Its Use as a Catalyst in the Valorization of CO ₂. ChemSusChem. 2020;13(7):1825-1833. doi:10.1002/cssc.201903384 apa: Hu, Y., Peglow, S., Longwitz, L., Frank, M., Epping, J. D., Brüser, V., & Werner, T. (2020). Plasma‐Assisted Immobilization of a Phosphonium Salt and Its Use as a Catalyst in the Valorization of CO ₂. ChemSusChem, 13(7), 1825–1833. https://doi.org/10.1002/cssc.201903384 bibtex: '@article{Hu_Peglow_Longwitz_Frank_Epping_Brüser_Werner_2020, title={Plasma‐Assisted Immobilization of a Phosphonium Salt and Its Use as a Catalyst in the Valorization of CO ₂}, volume={13}, DOI={10.1002/cssc.201903384}, number={7}, journal={ChemSusChem}, publisher={Wiley}, author={Hu, Yuya and Peglow, Sandra and Longwitz, Lars and Frank, Marcus and Epping, Jan Dirk and Brüser, Volker and Werner, Thomas}, year={2020}, pages={1825–1833} }' chicago: 'Hu, Yuya, Sandra Peglow, Lars Longwitz, Marcus Frank, Jan Dirk Epping, Volker Brüser, and Thomas Werner. “Plasma‐Assisted Immobilization of a Phosphonium Salt and Its Use as a Catalyst in the Valorization of CO ₂.” ChemSusChem 13, no. 7 (2020): 1825–33. https://doi.org/10.1002/cssc.201903384.' ieee: 'Y. Hu et al., “Plasma‐Assisted Immobilization of a Phosphonium Salt and Its Use as a Catalyst in the Valorization of CO ₂,” ChemSusChem, vol. 13, no. 7, pp. 1825–1833, 2020, doi: 10.1002/cssc.201903384.' mla: Hu, Yuya, et al. “Plasma‐Assisted Immobilization of a Phosphonium Salt and Its Use as a Catalyst in the Valorization of CO ₂.” ChemSusChem, vol. 13, no. 7, Wiley, 2020, pp. 1825–33, doi:10.1002/cssc.201903384. short: Y. Hu, S. Peglow, L. Longwitz, M. Frank, J.D. Epping, V. Brüser, T. Werner, ChemSusChem 13 (2020) 1825–1833. date_created: 2023-01-22T20:38:11Z date_updated: 2025-11-10T08:50:25Z department: - _id: '35' - _id: '2' - _id: '657' doi: 10.1002/cssc.201903384 extern: '1' intvolume: ' 13' issue: '7' keyword: - T2 - T1 - CSSD language: - iso: eng page: 1825-1833 publication: ChemSusChem publication_identifier: issn: - 1864-5631 - 1864-564X publication_status: published publisher: Wiley status: public title: Plasma‐Assisted Immobilization of a Phosphonium Salt and Its Use as a Catalyst in the Valorization of CO ₂ type: journal_article user_id: '89271' volume: 13 year: '2020' ... --- _id: '37952' article_number: '115496' author: - first_name: Aiga full_name: Grandane, Aiga last_name: Grandane - first_name: Alessio full_name: Nocentini, Alessio last_name: Nocentini - first_name: Thomas full_name: Werner, Thomas id: '89271' last_name: Werner orcid: 0000-0001-9025-3244 - first_name: Raivis full_name: Zalubovskis, Raivis last_name: Zalubovskis - first_name: Claudiu T. full_name: Supuran, Claudiu T. last_name: Supuran citation: ama: 'Grandane A, Nocentini A, Werner T, Zalubovskis R, Supuran CT. Benzoxepinones: A new isoform-selective class of tumor associated carbonic anhydrase inhibitors. Bioorganic and Medicinal Chemistry. 2020;28(11). doi:10.1016/j.bmc.2020.115496' apa: 'Grandane, A., Nocentini, A., Werner, T., Zalubovskis, R., & Supuran, C. T. (2020). Benzoxepinones: A new isoform-selective class of tumor associated carbonic anhydrase inhibitors. Bioorganic and Medicinal Chemistry, 28(11), Article 115496. https://doi.org/10.1016/j.bmc.2020.115496' bibtex: '@article{Grandane_Nocentini_Werner_Zalubovskis_Supuran_2020, title={Benzoxepinones: A new isoform-selective class of tumor associated carbonic anhydrase inhibitors}, volume={28}, DOI={10.1016/j.bmc.2020.115496}, number={11115496}, journal={Bioorganic and Medicinal Chemistry}, publisher={Elsevier BV}, author={Grandane, Aiga and Nocentini, Alessio and Werner, Thomas and Zalubovskis, Raivis and Supuran, Claudiu T.}, year={2020} }' chicago: 'Grandane, Aiga, Alessio Nocentini, Thomas Werner, Raivis Zalubovskis, and Claudiu T. Supuran. “Benzoxepinones: A New Isoform-Selective Class of Tumor Associated Carbonic Anhydrase Inhibitors.” Bioorganic and Medicinal Chemistry 28, no. 11 (2020). https://doi.org/10.1016/j.bmc.2020.115496.' ieee: 'A. Grandane, A. Nocentini, T. Werner, R. Zalubovskis, and C. T. Supuran, “Benzoxepinones: A new isoform-selective class of tumor associated carbonic anhydrase inhibitors,” Bioorganic and Medicinal Chemistry, vol. 28, no. 11, Art. no. 115496, 2020, doi: 10.1016/j.bmc.2020.115496.' mla: 'Grandane, Aiga, et al. “Benzoxepinones: A New Isoform-Selective Class of Tumor Associated Carbonic Anhydrase Inhibitors.” Bioorganic and Medicinal Chemistry, vol. 28, no. 11, 115496, Elsevier BV, 2020, doi:10.1016/j.bmc.2020.115496.' short: A. Grandane, A. Nocentini, T. Werner, R. Zalubovskis, C.T. Supuran, Bioorganic and Medicinal Chemistry 28 (2020). date_created: 2023-01-22T20:36:02Z date_updated: 2025-11-10T08:51:24Z department: - _id: '35' - _id: '2' - _id: '657' doi: 10.1016/j.bmc.2020.115496 extern: '1' intvolume: ' 28' issue: '11' keyword: - T4 - T2 - CSSD language: - iso: eng publication: Bioorganic and Medicinal Chemistry publication_identifier: issn: - 0968-0896 publication_status: published publisher: Elsevier BV status: public title: 'Benzoxepinones: A new isoform-selective class of tumor associated carbonic anhydrase inhibitors' type: journal_article user_id: '89271' volume: 28 year: '2020' ... --- _id: '37958' author: - first_name: Lars full_name: Longwitz, Lars last_name: Longwitz - first_name: Anke full_name: Spannenberg, Anke last_name: Spannenberg - first_name: Thomas full_name: Werner, Thomas id: '89271' last_name: Werner orcid: 0000-0001-9025-3244 citation: ama: Longwitz L, Spannenberg A, Werner T. Phosphetane Oxides as Redox Cycling Catalysts in the Catalytic Wittig Reaction at Room Temperature. ACS Catalysis. 2019;9(10):9237-9244. doi:10.1021/acscatal.9b02456 apa: Longwitz, L., Spannenberg, A., & Werner, T. (2019). Phosphetane Oxides as Redox Cycling Catalysts in the Catalytic Wittig Reaction at Room Temperature. ACS Catalysis, 9(10), 9237–9244. https://doi.org/10.1021/acscatal.9b02456 bibtex: '@article{Longwitz_Spannenberg_Werner_2019, title={Phosphetane Oxides as Redox Cycling Catalysts in the Catalytic Wittig Reaction at Room Temperature}, volume={9}, DOI={10.1021/acscatal.9b02456}, number={10}, journal={ACS Catalysis}, publisher={American Chemical Society (ACS)}, author={Longwitz, Lars and Spannenberg, Anke and Werner, Thomas}, year={2019}, pages={9237–9244} }' chicago: 'Longwitz, Lars, Anke Spannenberg, and Thomas Werner. “Phosphetane Oxides as Redox Cycling Catalysts in the Catalytic Wittig Reaction at Room Temperature.” ACS Catalysis 9, no. 10 (2019): 9237–44. https://doi.org/10.1021/acscatal.9b02456.' ieee: 'L. Longwitz, A. Spannenberg, and T. Werner, “Phosphetane Oxides as Redox Cycling Catalysts in the Catalytic Wittig Reaction at Room Temperature,” ACS Catalysis, vol. 9, no. 10, pp. 9237–9244, 2019, doi: 10.1021/acscatal.9b02456.' mla: Longwitz, Lars, et al. “Phosphetane Oxides as Redox Cycling Catalysts in the Catalytic Wittig Reaction at Room Temperature.” ACS Catalysis, vol. 9, no. 10, American Chemical Society (ACS), 2019, pp. 9237–44, doi:10.1021/acscatal.9b02456. short: L. Longwitz, A. Spannenberg, T. Werner, ACS Catalysis 9 (2019) 9237–9244. date_created: 2023-01-22T20:41:56Z date_updated: 2025-11-10T08:54:03Z department: - _id: '35' - _id: '2' - _id: '657' doi: 10.1021/acscatal.9b02456 extern: '1' intvolume: ' 9' issue: '10' keyword: - T2 - CSSD language: - iso: eng page: 9237-9244 publication: ACS Catalysis publication_identifier: issn: - 2155-5435 - 2155-5435 publication_status: published publisher: American Chemical Society (ACS) status: public title: Phosphetane Oxides as Redox Cycling Catalysts in the Catalytic Wittig Reaction at Room Temperature type: journal_article user_id: '89271' volume: 9 year: '2019' ... --- _id: '37962' author: - first_name: Lars full_name: Longwitz, Lars last_name: Longwitz - first_name: Stefan full_name: Jopp, Stefan last_name: Jopp - first_name: Thomas full_name: Werner, Thomas id: '89271' last_name: Werner orcid: 0000-0001-9025-3244 citation: ama: Longwitz L, Jopp S, Werner T. Organocatalytic Chlorination of Alcohols by P(III)/P(V) Redox Cycling. The Journal of Organic Chemistry. 2019;84(12):7863-7870. doi:10.1021/acs.joc.9b00741 apa: Longwitz, L., Jopp, S., & Werner, T. (2019). Organocatalytic Chlorination of Alcohols by P(III)/P(V) Redox Cycling. The Journal of Organic Chemistry, 84(12), 7863–7870. https://doi.org/10.1021/acs.joc.9b00741 bibtex: '@article{Longwitz_Jopp_Werner_2019, title={Organocatalytic Chlorination of Alcohols by P(III)/P(V) Redox Cycling}, volume={84}, DOI={10.1021/acs.joc.9b00741}, number={12}, journal={The Journal of Organic Chemistry}, publisher={American Chemical Society (ACS)}, author={Longwitz, Lars and Jopp, Stefan and Werner, Thomas}, year={2019}, pages={7863–7870} }' chicago: 'Longwitz, Lars, Stefan Jopp, and Thomas Werner. “Organocatalytic Chlorination of Alcohols by P(III)/P(V) Redox Cycling.” The Journal of Organic Chemistry 84, no. 12 (2019): 7863–70. https://doi.org/10.1021/acs.joc.9b00741.' ieee: 'L. Longwitz, S. Jopp, and T. Werner, “Organocatalytic Chlorination of Alcohols by P(III)/P(V) Redox Cycling,” The Journal of Organic Chemistry, vol. 84, no. 12, pp. 7863–7870, 2019, doi: 10.1021/acs.joc.9b00741.' mla: Longwitz, Lars, et al. “Organocatalytic Chlorination of Alcohols by P(III)/P(V) Redox Cycling.” The Journal of Organic Chemistry, vol. 84, no. 12, American Chemical Society (ACS), 2019, pp. 7863–70, doi:10.1021/acs.joc.9b00741. short: L. Longwitz, S. Jopp, T. Werner, The Journal of Organic Chemistry 84 (2019) 7863–7870. date_created: 2023-01-22T20:44:02Z date_updated: 2025-11-10T08:54:28Z department: - _id: '35' - _id: '2' - _id: '657' doi: 10.1021/acs.joc.9b00741 extern: '1' intvolume: ' 84' issue: '12' keyword: - T2 - CSSD language: - iso: eng page: 7863-7870 publication: The Journal of Organic Chemistry publication_identifier: issn: - 0022-3263 - 1520-6904 publication_status: published publisher: American Chemical Society (ACS) status: public title: Organocatalytic Chlorination of Alcohols by P(III)/P(V) Redox Cycling type: journal_article user_id: '89271' volume: 84 year: '2019' ... --- _id: '37959' abstract: - lang: eng text: Catalytic nucleophilic substitution of alcohols makes organic synthesis greener author: - first_name: Lars full_name: Longwitz, Lars last_name: Longwitz - first_name: Thomas full_name: Werner, Thomas id: '89271' last_name: Werner orcid: 0000-0001-9025-3244 citation: ama: Longwitz L, Werner T. The Mitsunobu reaction, reimagined. Science. 2019;365(6456):866-867. doi:10.1126/science.aay6635 apa: Longwitz, L., & Werner, T. (2019). The Mitsunobu reaction, reimagined. Science, 365(6456), 866–867. https://doi.org/10.1126/science.aay6635 bibtex: '@article{Longwitz_Werner_2019, title={The Mitsunobu reaction, reimagined}, volume={365}, DOI={10.1126/science.aay6635}, number={6456}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Longwitz, Lars and Werner, Thomas}, year={2019}, pages={866–867} }' chicago: 'Longwitz, Lars, and Thomas Werner. “The Mitsunobu Reaction, Reimagined.” Science 365, no. 6456 (2019): 866–67. https://doi.org/10.1126/science.aay6635.' ieee: 'L. Longwitz and T. Werner, “The Mitsunobu reaction, reimagined,” Science, vol. 365, no. 6456, pp. 866–867, 2019, doi: 10.1126/science.aay6635.' mla: Longwitz, Lars, and Thomas Werner. “The Mitsunobu Reaction, Reimagined.” Science, vol. 365, no. 6456, American Association for the Advancement of Science (AAAS), 2019, pp. 866–67, doi:10.1126/science.aay6635. short: L. Longwitz, T. Werner, Science 365 (2019) 866–867. date_created: 2023-01-22T20:42:20Z date_updated: 2025-11-10T09:01:38Z department: - _id: '35' - _id: '2' - _id: '657' doi: 10.1126/science.aay6635 intvolume: ' 365' issue: '6456' keyword: - T2 - CSSD language: - iso: eng page: 866-867 publication: Science publication_identifier: issn: - 0036-8075 - 1095-9203 publication_status: published publisher: American Association for the Advancement of Science (AAAS) status: public title: The Mitsunobu reaction, reimagined type: journal_article user_id: '89271' volume: 365 year: '2019' ... --- _id: '37966' abstract: - lang: eng text: "Abstract\r\n Numerous organic transformations are based on the use of stoichiometric amounts of phosphorus reagents. The formation of phosphane oxides from phosphanes is usually the thermodynamic driving force for these reactions. The stoichiometric amounts of phosphane oxide which are formed as by-products often significantly hamper the product purification. Organophosphorus catalysis based on P(III)/P(V) redox cycling aims to address these problems. Herein we present our recent advances in developing catalytic Wittig-type reactions. More specifically, we reported our results on catalytic Wittig reactions based on readily available Bu3P=O as pre-catalyst as well as the first microwave-assisted version of this reaction and the first enantioselective catalytic Wittig reaction utilizing chiral phosphane catalysts. Further developments led to the implementation of catalytic base-free Wittig reactions yielding highly functionalized alkylidene and arylidene succinates." author: - first_name: Lars full_name: Longwitz, Lars last_name: Longwitz - first_name: Thomas full_name: Werner, Thomas id: '89271' last_name: Werner orcid: 0000-0001-9025-3244 citation: ama: Longwitz L, Werner T. Recent advances in catalytic Wittig-type reactions based on P(III)/P(V) redox cycling. Pure and Applied Chemistry. 2019;91(1):95-102. doi:10.1515/pac-2018-0920 apa: Longwitz, L., & Werner, T. (2019). Recent advances in catalytic Wittig-type reactions based on P(III)/P(V) redox cycling. Pure and Applied Chemistry, 91(1), 95–102. https://doi.org/10.1515/pac-2018-0920 bibtex: '@article{Longwitz_Werner_2019, title={Recent advances in catalytic Wittig-type reactions based on P(III)/P(V) redox cycling}, volume={91}, DOI={10.1515/pac-2018-0920}, number={1}, journal={Pure and Applied Chemistry}, publisher={Walter de Gruyter GmbH}, author={Longwitz, Lars and Werner, Thomas}, year={2019}, pages={95–102} }' chicago: 'Longwitz, Lars, and Thomas Werner. “Recent Advances in Catalytic Wittig-Type Reactions Based on P(III)/P(V) Redox Cycling.” Pure and Applied Chemistry 91, no. 1 (2019): 95–102. https://doi.org/10.1515/pac-2018-0920.' ieee: 'L. Longwitz and T. Werner, “Recent advances in catalytic Wittig-type reactions based on P(III)/P(V) redox cycling,” Pure and Applied Chemistry, vol. 91, no. 1, pp. 95–102, 2019, doi: 10.1515/pac-2018-0920.' mla: Longwitz, Lars, and Thomas Werner. “Recent Advances in Catalytic Wittig-Type Reactions Based on P(III)/P(V) Redox Cycling.” Pure and Applied Chemistry, vol. 91, no. 1, Walter de Gruyter GmbH, 2019, pp. 95–102, doi:10.1515/pac-2018-0920. short: L. Longwitz, T. Werner, Pure and Applied Chemistry 91 (2019) 95–102. date_created: 2023-01-22T20:45:38Z date_updated: 2025-11-10T09:06:58Z department: - _id: '35' - _id: '2' - _id: '657' doi: 10.1515/pac-2018-0920 extern: '1' intvolume: ' 91' issue: '1' keyword: - T2 - CSSD language: - iso: eng page: 95-102 publication: Pure and Applied Chemistry publication_identifier: issn: - 1365-3075 - 0033-4545 publication_status: published publisher: Walter de Gruyter GmbH status: public title: Recent advances in catalytic Wittig-type reactions based on P(III)/P(V) redox cycling type: journal_article user_id: '89271' volume: 91 year: '2019' ... --- _id: '37965' author: - first_name: Aiga full_name: Grandane, Aiga last_name: Grandane - first_name: Lars full_name: Longwitz, Lars last_name: Longwitz - first_name: Catrin full_name: Roolf, Catrin last_name: Roolf - first_name: Anke full_name: Spannenberg, Anke last_name: Spannenberg - first_name: Hugo full_name: Murua Escobar, Hugo last_name: Murua Escobar - first_name: Christian full_name: Junghanss, Christian last_name: Junghanss - first_name: Edgars full_name: Suna, Edgars last_name: Suna - first_name: Thomas full_name: Werner, Thomas id: '89271' last_name: Werner orcid: 0000-0001-9025-3244 citation: ama: 'Grandane A, Longwitz L, Roolf C, et al. Intramolecular Base-Free Catalytic Wittig Reaction: Synthesis of Benzoxepinones. The Journal of Organic Chemistry. 2019;84(3):1320-1329. doi:10.1021/acs.joc.8b02789' apa: 'Grandane, A., Longwitz, L., Roolf, C., Spannenberg, A., Murua Escobar, H., Junghanss, C., Suna, E., & Werner, T. (2019). Intramolecular Base-Free Catalytic Wittig Reaction: Synthesis of Benzoxepinones. The Journal of Organic Chemistry, 84(3), 1320–1329. https://doi.org/10.1021/acs.joc.8b02789' bibtex: '@article{Grandane_Longwitz_Roolf_Spannenberg_Murua Escobar_Junghanss_Suna_Werner_2019, title={Intramolecular Base-Free Catalytic Wittig Reaction: Synthesis of Benzoxepinones}, volume={84}, DOI={10.1021/acs.joc.8b02789}, number={3}, journal={The Journal of Organic Chemistry}, publisher={American Chemical Society (ACS)}, author={Grandane, Aiga and Longwitz, Lars and Roolf, Catrin and Spannenberg, Anke and Murua Escobar, Hugo and Junghanss, Christian and Suna, Edgars and Werner, Thomas}, year={2019}, pages={1320–1329} }' chicago: 'Grandane, Aiga, Lars Longwitz, Catrin Roolf, Anke Spannenberg, Hugo Murua Escobar, Christian Junghanss, Edgars Suna, and Thomas Werner. “Intramolecular Base-Free Catalytic Wittig Reaction: Synthesis of Benzoxepinones.” The Journal of Organic Chemistry 84, no. 3 (2019): 1320–29. https://doi.org/10.1021/acs.joc.8b02789.' ieee: 'A. Grandane et al., “Intramolecular Base-Free Catalytic Wittig Reaction: Synthesis of Benzoxepinones,” The Journal of Organic Chemistry, vol. 84, no. 3, pp. 1320–1329, 2019, doi: 10.1021/acs.joc.8b02789.' mla: 'Grandane, Aiga, et al. “Intramolecular Base-Free Catalytic Wittig Reaction: Synthesis of Benzoxepinones.” The Journal of Organic Chemistry, vol. 84, no. 3, American Chemical Society (ACS), 2019, pp. 1320–29, doi:10.1021/acs.joc.8b02789.' short: A. Grandane, L. Longwitz, C. Roolf, A. Spannenberg, H. Murua Escobar, C. Junghanss, E. Suna, T. Werner, The Journal of Organic Chemistry 84 (2019) 1320–1329. date_created: 2023-01-22T20:45:12Z date_updated: 2025-11-10T09:10:18Z department: - _id: '35' - _id: '2' - _id: '657' doi: 10.1021/acs.joc.8b02789 extern: '1' intvolume: ' 84' issue: '3' keyword: - T2 - T4 - CSSD language: - iso: eng page: 1320-1329 publication: The Journal of Organic Chemistry publication_identifier: issn: - 0022-3263 - 1520-6904 publication_status: published publisher: American Chemical Society (ACS) status: public title: 'Intramolecular Base-Free Catalytic Wittig Reaction: Synthesis of Benzoxepinones' type: journal_article user_id: '89271' volume: 84 year: '2019' ... --- _id: '37967' author: - first_name: Johannes full_name: Steinbauer, Johannes last_name: Steinbauer - first_name: Christoph full_name: Kubis, Christoph last_name: Kubis - first_name: Ralf full_name: Ludwig, Ralf last_name: Ludwig - first_name: Thomas full_name: Werner, Thomas id: '89271' last_name: Werner orcid: 0000-0001-9025-3244 citation: ama: 'Steinbauer J, Kubis C, Ludwig R, Werner T. Mechanistic Study on the Addition of CO₂ to Epoxides Catalyzed by Ammonium and Phosphonium Salts: A Combined Spectroscopic and Kinetic Approach. ACS Sustainable Chemistry and Engineering. 2018;6(8):10778-10788. doi:10.1021/acssuschemeng.8b02093' apa: 'Steinbauer, J., Kubis, C., Ludwig, R., & Werner, T. (2018). Mechanistic Study on the Addition of CO₂ to Epoxides Catalyzed by Ammonium and Phosphonium Salts: A Combined Spectroscopic and Kinetic Approach. ACS Sustainable Chemistry and Engineering, 6(8), 10778–10788. https://doi.org/10.1021/acssuschemeng.8b02093' bibtex: '@article{Steinbauer_Kubis_Ludwig_Werner_2018, title={Mechanistic Study on the Addition of CO₂ to Epoxides Catalyzed by Ammonium and Phosphonium Salts: A Combined Spectroscopic and Kinetic Approach}, volume={6}, DOI={10.1021/acssuschemeng.8b02093}, number={8}, journal={ACS Sustainable Chemistry and Engineering}, publisher={American Chemical Society (ACS)}, author={Steinbauer, Johannes and Kubis, Christoph and Ludwig, Ralf and Werner, Thomas}, year={2018}, pages={10778–10788} }' chicago: 'Steinbauer, Johannes, Christoph Kubis, Ralf Ludwig, and Thomas Werner. “Mechanistic Study on the Addition of CO₂ to Epoxides Catalyzed by Ammonium and Phosphonium Salts: A Combined Spectroscopic and Kinetic Approach.” ACS Sustainable Chemistry and Engineering 6, no. 8 (2018): 10778–88. https://doi.org/10.1021/acssuschemeng.8b02093.' ieee: 'J. Steinbauer, C. Kubis, R. Ludwig, and T. Werner, “Mechanistic Study on the Addition of CO₂ to Epoxides Catalyzed by Ammonium and Phosphonium Salts: A Combined Spectroscopic and Kinetic Approach,” ACS Sustainable Chemistry and Engineering, vol. 6, no. 8, pp. 10778–10788, 2018, doi: 10.1021/acssuschemeng.8b02093.' mla: 'Steinbauer, Johannes, et al. “Mechanistic Study on the Addition of CO₂ to Epoxides Catalyzed by Ammonium and Phosphonium Salts: A Combined Spectroscopic and Kinetic Approach.” ACS Sustainable Chemistry and Engineering, vol. 6, no. 8, American Chemical Society (ACS), 2018, pp. 10778–88, doi:10.1021/acssuschemeng.8b02093.' short: J. Steinbauer, C. Kubis, R. Ludwig, T. Werner, ACS Sustainable Chemistry and Engineering 6 (2018) 10778–10788. date_created: 2023-01-22T20:46:04Z date_updated: 2025-11-10T09:04:50Z department: - _id: '35' - _id: '2' - _id: '657' doi: 10.1021/acssuschemeng.8b02093 extern: '1' intvolume: ' 6' issue: '8' keyword: - T1 - T2 - CSSD language: - iso: eng page: 10778-10788 publication: ACS Sustainable Chemistry and Engineering publication_identifier: issn: - 2168-0485 - 2168-0485 publication_status: published publisher: American Chemical Society (ACS) status: public title: 'Mechanistic Study on the Addition of CO₂ to Epoxides Catalyzed by Ammonium and Phosphonium Salts: A Combined Spectroscopic and Kinetic Approach' type: journal_article user_id: '89271' volume: 6 year: '2018' ... --- _id: '37973' abstract: - lang: eng text:

An immobilized bifunctional phosphonium salt catalyst efficiently catalyzed the synthesis of cyclic carbonates under mild conditions, and was reused up to 15 times.

author: - first_name: J. full_name: Steinbauer, J. last_name: Steinbauer - first_name: L. full_name: Longwitz, L. last_name: Longwitz - first_name: M. full_name: Frank, M. last_name: Frank - first_name: J. full_name: Epping, J. last_name: Epping - first_name: U. full_name: Kragl, U. last_name: Kragl - first_name: Thomas full_name: Werner, Thomas id: '89271' last_name: Werner orcid: 0000-0001-9025-3244 citation: ama: Steinbauer J, Longwitz L, Frank M, Epping J, Kragl U, Werner T. Immobilized bifunctional phosphonium salts as recyclable organocatalysts in the cycloaddition of CO₂ and epoxides. Green Chemistry. 2017;19(18):4435-4445. doi:10.1039/c7gc01782k apa: Steinbauer, J., Longwitz, L., Frank, M., Epping, J., Kragl, U., & Werner, T. (2017). Immobilized bifunctional phosphonium salts as recyclable organocatalysts in the cycloaddition of CO₂ and epoxides. Green Chemistry, 19(18), 4435–4445. https://doi.org/10.1039/c7gc01782k bibtex: '@article{Steinbauer_Longwitz_Frank_Epping_Kragl_Werner_2017, title={Immobilized bifunctional phosphonium salts as recyclable organocatalysts in the cycloaddition of CO₂ and epoxides}, volume={19}, DOI={10.1039/c7gc01782k}, number={18}, journal={Green Chemistry}, publisher={Royal Society of Chemistry (RSC)}, author={Steinbauer, J. and Longwitz, L. and Frank, M. and Epping, J. and Kragl, U. and Werner, Thomas}, year={2017}, pages={4435–4445} }' chicago: 'Steinbauer, J., L. Longwitz, M. Frank, J. Epping, U. Kragl, and Thomas Werner. “Immobilized Bifunctional Phosphonium Salts as Recyclable Organocatalysts in the Cycloaddition of CO₂ and Epoxides.” Green Chemistry 19, no. 18 (2017): 4435–45. https://doi.org/10.1039/c7gc01782k.' ieee: 'J. Steinbauer, L. Longwitz, M. Frank, J. Epping, U. Kragl, and T. Werner, “Immobilized bifunctional phosphonium salts as recyclable organocatalysts in the cycloaddition of CO₂ and epoxides,” Green Chemistry, vol. 19, no. 18, pp. 4435–4445, 2017, doi: 10.1039/c7gc01782k.' mla: Steinbauer, J., et al. “Immobilized Bifunctional Phosphonium Salts as Recyclable Organocatalysts in the Cycloaddition of CO₂ and Epoxides.” Green Chemistry, vol. 19, no. 18, Royal Society of Chemistry (RSC), 2017, pp. 4435–45, doi:10.1039/c7gc01782k. short: J. Steinbauer, L. Longwitz, M. Frank, J. Epping, U. Kragl, T. Werner, Green Chemistry 19 (2017) 4435–4445. date_created: 2023-01-22T20:57:38Z date_updated: 2025-11-10T09:18:10Z department: - _id: '35' - _id: '2' - _id: '657' doi: 10.1039/c7gc01782k extern: '1' intvolume: ' 19' issue: '18' keyword: - T1 - T2 - CSSD language: - iso: eng page: 4435-4445 publication: Green Chemistry publication_identifier: issn: - 1463-9262 - 1463-9270 publication_status: published publisher: Royal Society of Chemistry (RSC) status: public title: Immobilized bifunctional phosphonium salts as recyclable organocatalysts in the cycloaddition of CO₂ and epoxides type: journal_article user_id: '89271' volume: 19 year: '2017' ...