@article{62086,
  author       = {{Stefanow, Vivian and Kell, Lukas and Leduskrasta, Aiga and Eh, Marcus and Panten, Johannes and Werner, Thomas}},
  issn         = {{0022-3263}},
  journal      = {{The Journal of Organic Chemistry}},
  keywords     = {{T4, CSSD}},
  number       = {{37}},
  pages        = {{12877--12887}},
  publisher    = {{American Chemical Society (ACS)}},
  title        = {{{Straightforward Access to Terpene-Based 1,2-Diols and Their Acetals as Fragrance Ingredients}}},
  doi          = {{10.1021/acs.joc.5c00889}},
  volume       = {{90}},
  year         = {{2025}},
}

@article{62092,
  author       = {{Nyemeck, Suzanne L. and Eyong, Kenneth O. and Bidingha, Ronald and Kamdem, Michael HK. and Ndinteh, Derek T. and Odumosu, Patricia O. and Folefoc, Gabriel N. and Bilanda, Danielle C. and Egbe, Andrew E. and Werner, Thomas and Bekono, Boris D. and Ntie-Kang, Fidele}},
  issn         = {{1874-3900}},
  journal      = {{Phytochemistry Letters}},
  keywords     = {{T4}},
  pages        = {{59--67}},
  publisher    = {{Elsevier BV}},
  title        = {{{Design, isolation, synthesis, and mechanistic insight of flavonoids isolated from Beilschmiedia obscura, as potential α-glucosidase inhibitors}}},
  doi          = {{10.1016/j.phytol.2024.06.004}},
  volume       = {{62}},
  year         = {{2024}},
}

@article{62094,
  author       = {{Yemback, Pierre and Eyong, Kenneth O. and Efange, Noella M. and Kamdem, Michael HK. and Ndinteh, Derek T. and Odumosu, Patricia O. and Folefoc, Gabriel N. and Ayong, Lawrence and Werner, Thomas}},
  issn         = {{1874-3900}},
  journal      = {{Phytochemistry Letters}},
  keywords     = {{T4}},
  pages        = {{26--35}},
  publisher    = {{Elsevier BV}},
  title        = {{{Lupane derivatives: Design, isolation, synthesis and evaluation of antiplasmodial activity against Plasmodium falciparum 3D7 strain}}},
  doi          = {{10.1016/j.phytol.2023.06.009}},
  volume       = {{57}},
  year         = {{2023}},
}

@article{62096,
  abstract     = {{<jats:title>Abstract</jats:title><jats:p>The biocatalytic kinetic resolution of cyclic carbonates derived from glycerol is reported. A selection of 26 esterases and lipases was tested for the asymmetric hydrolysis of the model substrate (epichlorohydrin carbonate) in aqueous medium. Among them, Pig Liver Esterase and Novozym® 435 showed the best selectivity with <jats:italic>E</jats:italic>=38 and 49, respectively. Both enzymes were employed for the conversion of 12 glycerol derivatives under optimized conditions. The resolution of halogenated carbonates afforded the unconverted enantiomer in up to &gt;99 : 1 <jats:italic>er</jats:italic>. Furthermore, Novozym® 435 was successfully recycled 10 times without significant loss of activity. Upscaling and isolation of the chiral carbonate was also demonstrated. Subsequent conversion of this chiral building block allowed the direct one‐pot synthesis of (<jats:italic>S</jats:italic>)‐Guaifenesin, (<jats:italic>S</jats:italic>)‐Mephenesin and (<jats:italic>S</jats:italic>)‐Chlorphenesin in up to 89 % yield and 94 : 6 <jats:italic>er</jats:italic>.</jats:p>}},
  author       = {{Terazzi, Constanza and Spannenberg, Anke and von Langermann, Jan and Werner, Thomas}},
  issn         = {{1867-3880}},
  journal      = {{ChemCatChem}},
  keywords     = {{T1, T4, CSSD}},
  number       = {{19}},
  publisher    = {{Wiley}},
  title        = {{{Chemoenzymatic Synthesis of Chiral Building Blocks Based on the Kinetic Resolution of Glycerol‐Derived Cyclic Carbonates}}},
  doi          = {{10.1002/cctc.202300917}},
  volume       = {{15}},
  year         = {{2023}},
}

@article{37946,
  abstract     = {{<jats:title>Abstract</jats:title><jats:p>The facile synthesis of highly functionalized building blocks with potential biological activity is of great interest to medicinal chemistry. The benzoxepinone core structures commonly exhibit biological activity. Thus, a short and efficient synthetic route towards benzoxepine containing scaffold, which enables late stage modification was developed. Namely, base-free catalytic Wittig reactions enabled the synthesis of bromobenzoxepinones from readily available starting materials. Subsequent, Suzuki–Miyaura and Stille reactions proved to be suitable methods to access a variety of benzoxepinone diaryl derivatives by late stage modification in only three steps. This three-step reaction sequence is suitable for high throughput applications and gives facile access to highly complex molecular structures, which are suitable for further functionalization. The antiproliferative properties of selected arylbenzoxepinones­ were tested in vitro on monolayer tumor cell line A549. Notably, in this initial screening, these compounds were found to be active in the micromolar range.</jats:p>}},
  author       = {{Werner, Thomas and Grandane, Aiga and Pudnika, Linda and Domraceva, Ilona and Zalubovskis, Raivis}},
  issn         = {{0039-7881}},
  journal      = {{Synthesis}},
  keywords     = {{T2, T4, CSSD}},
  number       = {{19}},
  pages        = {{3545--3554}},
  publisher    = {{Georg Thieme Verlag KG}},
  title        = {{{Base-Free Catalytic Wittig-/Cross-Coupling Reaction Sequence as Short Synthetic Strategy for the Preparation of Highly Functionalized Arylbenzoxepinones}}},
  doi          = {{10.1055/a-1509-6078}},
  volume       = {{53}},
  year         = {{2021}},
}

@article{62098,
  author       = {{Stefanow, Vivian and Grandane, Aiga and Eh, Marcus and Panten, Johannes and Spannenberg, Anke and Werner, Thomas}},
  issn         = {{1083-6160}},
  journal      = {{Organic Process Research &amp; Development}},
  keywords     = {{T4, CSSD}},
  number       = {{1}},
  pages        = {{89--97}},
  publisher    = {{American Chemical Society (ACS)}},
  title        = {{{Stereoselective Synthesis of a<i>cis</i>-Cedrane-8,9-diol as a Key Intermediate for an Amber Odorant}}},
  doi          = {{10.1021/acs.oprd.0c00423}},
  volume       = {{25}},
  year         = {{2021}},
}

@article{62099,
  author       = {{Stefanow, Vivian and Grandane, Aiga and Eh, Marcus and Panten, Johannes and Spannenberg, Anke and Werner, Thomas}},
  issn         = {{1083-6160}},
  journal      = {{Organic Process Research &amp; Development}},
  keywords     = {{T4, CSSD}},
  number       = {{1}},
  pages        = {{89--97}},
  publisher    = {{American Chemical Society (ACS)}},
  title        = {{{Stereoselective Synthesis of a<i>cis</i>-Cedrane-8,9-diol as a Key Intermediate for an Amber Odorant}}},
  doi          = {{10.1021/acs.oprd.0c00423}},
  volume       = {{25}},
  year         = {{2021}},
}

@article{37943,
  author       = {{Wirth, Marisa A. and Longwitz, Lars and Kanwischer, Marion and Gros, Peter and Leinweber, Peter and Werner, Thomas}},
  issn         = {{0147-6513}},
  journal      = {{Ecotoxicology and Environmental Safety}},
  keywords     = {{T4, CSSD}},
  publisher    = {{Elsevier BV}},
  title        = {{{AMPA-15N – Synthesis and application as standard compound in traceable degradation studies of glyphosate}}},
  doi          = {{10.1016/j.ecoenv.2021.112768}},
  volume       = {{225}},
  year         = {{2021}},
}

@article{62101,
  abstract     = {{<jats:title>Abstract</jats:title><jats:p>The carbon–carbon double bond of unsaturated carbonyl compounds was readily reduced by using a phosphetane oxide catalyst in the presence of a simple organosilane as the terminal reductant and water as the hydrogen source. Quantitative hydrogenation was observed when 1.0 mol % of a methyl‐substituted phosphetane oxide was employed as the catalyst. The procedure is highly selective towards activated double bonds, tolerating a variety of functional groups that are usually prone to reduction. In total, 25 alkenes and two alkynes were hydrogenated to the corresponding alkanes in excellent yields of up to 99 %. Notably, less active poly(methylhydrosiloxane) could also be utilized as the terminal reductant. Mechanistic investigations revealed the phosphane as the catalyst resting state and a protonation/deprotonation sequence as the crucial step in the catalytic cycle.</jats:p>}},
  author       = {{Longwitz, Lars and Werner, Thomas}},
  issn         = {{0044-8249}},
  journal      = {{Angewandte Chemie}},
  keywords     = {{T2, T4}},
  number       = {{7}},
  pages        = {{2782--2785}},
  publisher    = {{Wiley}},
  title        = {{{Reduction of Activated Alkenes by P<sup>III</sup>/P<sup>V</sup> Redox Cycling Catalysis}}},
  doi          = {{10.1002/ange.201912991}},
  volume       = {{132}},
  year         = {{2020}},
}

@misc{62147,
  author       = {{Werner, Thomas and Stefanow, V. and Grandane, A. and Panten, J. and Eh, M.}},
  keywords     = {{T4}},
  title        = {{{Novel processes for preparing cis-cedrandiol}}},
  year         = {{2020}},
}

@article{62102,
  abstract     = {{<jats:title>Abstract</jats:title><jats:p>The carbon–carbon double bond of unsaturated carbonyl compounds was readily reduced by using a phosphetane oxide catalyst in the presence of a simple organosilane as the terminal reductant and water as the hydrogen source. Quantitative hydrogenation was observed when 1.0 mol % of a methyl‐substituted phosphetane oxide was employed as the catalyst. The procedure is highly selective towards activated double bonds, tolerating a variety of functional groups that are usually prone to reduction. In total, 25 alkenes and two alkynes were hydrogenated to the corresponding alkanes in excellent yields of up to 99 %. Notably, less active poly(methylhydrosiloxane) could also be utilized as the terminal reductant. Mechanistic investigations revealed the phosphane as the catalyst resting state and a protonation/deprotonation sequence as the crucial step in the catalytic cycle.</jats:p>}},
  author       = {{Longwitz, Lars and Werner, Thomas}},
  issn         = {{1433-7851}},
  journal      = {{Angewandte Chemie International Edition}},
  keywords     = {{T2, T4, CSSD}},
  number       = {{7}},
  pages        = {{2760--2763}},
  publisher    = {{Wiley}},
  title        = {{{Reduction of Activated Alkenes by P<sup>III</sup>/P<sup>V</sup> Redox Cycling Catalysis}}},
  doi          = {{10.1002/anie.201912991}},
  volume       = {{59}},
  year         = {{2020}},
}

@article{37952,
  author       = {{Grandane, Aiga and Nocentini, Alessio and Werner, Thomas and Zalubovskis, Raivis and Supuran, Claudiu T.}},
  issn         = {{0968-0896}},
  journal      = {{Bioorganic and Medicinal Chemistry}},
  keywords     = {{T4, T2, CSSD}},
  number       = {{11}},
  publisher    = {{Elsevier BV}},
  title        = {{{Benzoxepinones: A new isoform-selective class of tumor associated carbonic anhydrase inhibitors}}},
  doi          = {{10.1016/j.bmc.2020.115496}},
  volume       = {{28}},
  year         = {{2020}},
}

@article{37963,
  author       = {{Büttner, Hendrik and Kohrt, Christina and Wulf, Christoph and Schäffner, Benjamin and Groenke, Karsten and Hu, Yuya and Kruse, Daniela and Werner, Thomas}},
  issn         = {{1864-5631}},
  journal      = {{ChemSusChem}},
  keywords     = {{T1, T4, CSSD}},
  number       = {{12}},
  pages        = {{2701--2707}},
  publisher    = {{Wiley}},
  title        = {{{Life Cycle Assessment for the Organocatalytic Synthesis of Glycerol Carbonate Methacrylate}}},
  doi          = {{10.1002/cssc.201900678}},
  volume       = {{12}},
  year         = {{2019}},
}

@article{37960,
  author       = {{Stadler, Bernhard M. and Wulf, Christoph and Werner, Thomas and Tin, Sergey and de Vries, Johannes G.}},
  issn         = {{2155-5435}},
  journal      = {{ACS Catalysis}},
  keywords     = {{T4, CSSD}},
  number       = {{9}},
  pages        = {{8012--8067}},
  publisher    = {{American Chemical Society (ACS)}},
  title        = {{{Catalytic Approaches to Monomers for Polymers Based on Renewables}}},
  doi          = {{10.1021/acscatal.9b01665}},
  volume       = {{9}},
  year         = {{2019}},
}

@article{37965,
  author       = {{Grandane, Aiga and Longwitz, Lars and Roolf, Catrin and Spannenberg, Anke and Murua Escobar, Hugo and Junghanss, Christian and Suna, Edgars and Werner, Thomas}},
  issn         = {{0022-3263}},
  journal      = {{The Journal of Organic Chemistry}},
  keywords     = {{T2, T4, CSSD}},
  number       = {{3}},
  pages        = {{1320--1329}},
  publisher    = {{American Chemical Society (ACS)}},
  title        = {{{Intramolecular Base-Free Catalytic Wittig Reaction: Synthesis of Benzoxepinones}}},
  doi          = {{10.1021/acs.joc.8b02789}},
  volume       = {{84}},
  year         = {{2019}},
}

@article{62105,
  author       = {{Longwitz, Lars and Steinbauer, Johannes and Spannenberg, Anke and Werner, Thomas}},
  issn         = {{2155-5435}},
  journal      = {{ACS Catalysis}},
  keywords     = {{T1, T3, T4, CSSD}},
  number       = {{1}},
  pages        = {{665--672}},
  publisher    = {{American Chemical Society (ACS)}},
  title        = {{{Calcium-Based Catalytic System for the Synthesis of Bio-Derived Cyclic Carbonates under Mild Conditions}}},
  doi          = {{10.1021/acscatal.7b03367}},
  volume       = {{8}},
  year         = {{2018}},
}

@article{37970,
  author       = {{Longwitz, Lars and Steinbauer, Johannes and Spannenberg, Anke and Werner, Thomas}},
  issn         = {{2155-5435}},
  journal      = {{ACS Catalysis}},
  keywords     = {{T1, T3, T4}},
  number       = {{1}},
  pages        = {{665--672}},
  publisher    = {{American Chemical Society (ACS)}},
  title        = {{{Calcium-Based Catalytic System for the Synthesis of Bio-Derived Cyclic Carbonates under Mild Conditions}}},
  doi          = {{10.1021/acscatal.7b03367}},
  volume       = {{8}},
  year         = {{2017}},
}