---
_id: '64884'
abstract:
- lang: eng
  text: "To address the challenges associated with poor drug solubility and uncontrolled
    drug release in conventional dosage forms, a combination of polymer design and
    advanced drug delivery approaches has been employed. The development of pH-responsive
    nanoparticles for controlled and selective drug release represents a notable advance
    in adaptive nanomedicine. This study explores the design of a pH-responsive polymer,
    poly(1,4-phenyleneacetone dimethylene ketal) (PPADK). Additionally, the incorporation
    of light-responsive ortho-nitrobenzyl groups (o-NB-PPADK) enhanced the degradation
    upon exposure to light. Based on the polymer, nanoparticles were prepared using
    the solvent displacement method. The fluorescence dye Lumogen® Red was incorporated
    as a model substance. The nanoparticles were characterized by dynamic light scattering
    to determine their hydrodynamic diameter and size distribution, and the surface
    charge was analyzed. Atomic force microscopy was used to visualize the surface
    morphology. The nanoparticles remained stable under physiological pH conditions
    while exhibiting accelerated degradation and substance release in acidic environment,
    a property potentially exploitable for tumor targeting. Further enhanced degradation
    and correspondingly increased release was achieved by incorporating light-responsive
    elements in the polymer structure.\r\nThe cytotoxicity of these newly designed
    nanoparticles was evaluated in cell culture using a breast cancer cell line. These
    results support the potential of o-NB-PPADK nanoparticles as a possible candidate
    for selective and effective cancer therapy, combining stimuli-responsive degradation
    mechanisms for improved therapeutic outcomes."
article_number: '126127'
article_type: original
author:
- first_name: Maurice
  full_name: Kramer, Maurice
  last_name: Kramer
- first_name: Matthias
  full_name: van der Linde, Matthias
  last_name: van der Linde
- first_name: Lisa
  full_name: Hönscheid, Lisa
  last_name: Hönscheid
- first_name: Corinna
  full_name: Horky, Corinna
  last_name: Horky
- first_name: Katharina
  full_name: Völlmecke, Katharina
  last_name: Völlmecke
- first_name: Dennis
  full_name: Mulac, Dennis
  last_name: Mulac
- first_name: Fabian
  full_name: Herrmann, Fabian
  last_name: Herrmann
- first_name: Dirk
  full_name: Kuckling, Dirk
  id: '287'
  last_name: Kuckling
- first_name: Klaus
  full_name: Langer, Klaus
  last_name: Langer
citation:
  ama: 'Kramer M, van der Linde M, Hönscheid L, et al. Enlightening release strategies:
    Accelerated nanoparticle degradation and substance release utilizing light- and
    pH-responsive polymers. <i>International Journal of Pharmaceutics</i>. 2025;684.
    doi:<a href="https://doi.org/10.1016/j.ijpharm.2025.126127">10.1016/j.ijpharm.2025.126127</a>'
  apa: 'Kramer, M., van der Linde, M., Hönscheid, L., Horky, C., Völlmecke, K., Mulac,
    D., Herrmann, F., Kuckling, D., &#38; Langer, K. (2025). Enlightening release
    strategies: Accelerated nanoparticle degradation and substance release utilizing
    light- and pH-responsive polymers. <i>International Journal of Pharmaceutics</i>,
    <i>684</i>, Article 126127. <a href="https://doi.org/10.1016/j.ijpharm.2025.126127">https://doi.org/10.1016/j.ijpharm.2025.126127</a>'
  bibtex: '@article{Kramer_van der Linde_Hönscheid_Horky_Völlmecke_Mulac_Herrmann_Kuckling_Langer_2025,
    title={Enlightening release strategies: Accelerated nanoparticle degradation and
    substance release utilizing light- and pH-responsive polymers}, volume={684},
    DOI={<a href="https://doi.org/10.1016/j.ijpharm.2025.126127">10.1016/j.ijpharm.2025.126127</a>},
    number={126127}, journal={International Journal of Pharmaceutics}, publisher={Elsevier
    BV}, author={Kramer, Maurice and van der Linde, Matthias and Hönscheid, Lisa and
    Horky, Corinna and Völlmecke, Katharina and Mulac, Dennis and Herrmann, Fabian
    and Kuckling, Dirk and Langer, Klaus}, year={2025} }'
  chicago: 'Kramer, Maurice, Matthias van der Linde, Lisa Hönscheid, Corinna Horky,
    Katharina Völlmecke, Dennis Mulac, Fabian Herrmann, Dirk Kuckling, and Klaus Langer.
    “Enlightening Release Strategies: Accelerated Nanoparticle Degradation and Substance
    Release Utilizing Light- and PH-Responsive Polymers.” <i>International Journal
    of Pharmaceutics</i> 684 (2025). <a href="https://doi.org/10.1016/j.ijpharm.2025.126127">https://doi.org/10.1016/j.ijpharm.2025.126127</a>.'
  ieee: 'M. Kramer <i>et al.</i>, “Enlightening release strategies: Accelerated nanoparticle
    degradation and substance release utilizing light- and pH-responsive polymers,”
    <i>International Journal of Pharmaceutics</i>, vol. 684, Art. no. 126127, 2025,
    doi: <a href="https://doi.org/10.1016/j.ijpharm.2025.126127">10.1016/j.ijpharm.2025.126127</a>.'
  mla: 'Kramer, Maurice, et al. “Enlightening Release Strategies: Accelerated Nanoparticle
    Degradation and Substance Release Utilizing Light- and PH-Responsive Polymers.”
    <i>International Journal of Pharmaceutics</i>, vol. 684, 126127, Elsevier BV,
    2025, doi:<a href="https://doi.org/10.1016/j.ijpharm.2025.126127">10.1016/j.ijpharm.2025.126127</a>.'
  short: M. Kramer, M. van der Linde, L. Hönscheid, C. Horky, K. Völlmecke, D. Mulac,
    F. Herrmann, D. Kuckling, K. Langer, International Journal of Pharmaceutics 684
    (2025).
date_created: 2026-03-11T08:46:17Z
date_updated: 2026-03-11T08:52:22Z
department:
- _id: '163'
doi: 10.1016/j.ijpharm.2025.126127
intvolume: '       684'
keyword:
- Nanoparticles
- Drug delivery
- Controlled release
- Stimuli-responsiveTumor targeting
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/S0378517325009640?via%3Dihub
publication: International Journal of Pharmaceutics
publication_identifier:
  issn:
  - 0378-5173
publication_status: published
publisher: Elsevier BV
status: public
title: 'Enlightening release strategies: Accelerated nanoparticle degradation and
  substance release utilizing light- and pH-responsive polymers'
type: journal_article
user_id: '94'
volume: 684
year: '2025'
...
---
_id: '30927'
article_number: '6081'
author:
- first_name: Berthold
  full_name: Reis, Berthold
  last_name: Reis
- first_name: David
  full_name: Vehlow, David
  last_name: Vehlow
- first_name: Tarik
  full_name: Rust, Tarik
  last_name: Rust
- first_name: Dirk
  full_name: Kuckling, Dirk
  id: '287'
  last_name: Kuckling
- first_name: Martin
  full_name: Müller, Martin
  last_name: Müller
citation:
  ama: Reis B, Vehlow D, Rust T, Kuckling D, Müller M. Thermoresponsive Catechol Based-Polyelectrolyte
    Complex Coatings for Controlled Release of Bortezomib. <i>International Journal
    of Molecular Science</i>. 2019;20(23). doi:<a href="https://doi.org/10.3390/ijms20236081">10.3390/ijms20236081</a>
  apa: Reis, B., Vehlow, D., Rust, T., Kuckling, D., &#38; Müller, M. (2019). Thermoresponsive
    Catechol Based-Polyelectrolyte Complex Coatings for Controlled Release of Bortezomib.
    <i>International Journal of Molecular Science</i>, <i>20</i>(23), Article 6081.
    <a href="https://doi.org/10.3390/ijms20236081">https://doi.org/10.3390/ijms20236081</a>
  bibtex: '@article{Reis_Vehlow_Rust_Kuckling_Müller_2019, title={Thermoresponsive
    Catechol Based-Polyelectrolyte Complex Coatings for Controlled Release of Bortezomib},
    volume={20}, DOI={<a href="https://doi.org/10.3390/ijms20236081">10.3390/ijms20236081</a>},
    number={236081}, journal={International Journal of Molecular Science}, publisher={MDPI},
    author={Reis, Berthold and Vehlow, David and Rust, Tarik and Kuckling, Dirk and
    Müller, Martin}, year={2019} }'
  chicago: Reis, Berthold, David Vehlow, Tarik Rust, Dirk Kuckling, and Martin Müller.
    “Thermoresponsive Catechol Based-Polyelectrolyte Complex Coatings for Controlled
    Release of Bortezomib.” <i>International Journal of Molecular Science</i> 20,
    no. 23 (2019). <a href="https://doi.org/10.3390/ijms20236081">https://doi.org/10.3390/ijms20236081</a>.
  ieee: 'B. Reis, D. Vehlow, T. Rust, D. Kuckling, and M. Müller, “Thermoresponsive
    Catechol Based-Polyelectrolyte Complex Coatings for Controlled Release of Bortezomib,”
    <i>International Journal of Molecular Science</i>, vol. 20, no. 23, Art. no. 6081,
    2019, doi: <a href="https://doi.org/10.3390/ijms20236081">10.3390/ijms20236081</a>.'
  mla: Reis, Berthold, et al. “Thermoresponsive Catechol Based-Polyelectrolyte Complex
    Coatings for Controlled Release of Bortezomib.” <i>International Journal of Molecular
    Science</i>, vol. 20, no. 23, 6081, MDPI, 2019, doi:<a href="https://doi.org/10.3390/ijms20236081">10.3390/ijms20236081</a>.
  short: B. Reis, D. Vehlow, T. Rust, D. Kuckling, M. Müller, International Journal
    of Molecular Science 20 (2019).
date_created: 2022-04-21T09:00:09Z
date_updated: 2022-04-21T09:00:31Z
department:
- _id: '311'
doi: 10.3390/ijms20236081
intvolume: '        20'
issue: '23'
keyword:
- catechol chemistry
- poly(caffeic acid)
- polyelectrolyte complex coatings
- thermoresponsive coatings
- controlled release
- bortezomib
- multiple myeloma
language:
- iso: eng
publication: International Journal of Molecular Science
publication_status: published
publisher: MDPI
status: public
title: Thermoresponsive Catechol Based-Polyelectrolyte Complex Coatings for Controlled
  Release of Bortezomib
type: journal_article
user_id: '94'
volume: 20
year: '2019'
...