---
_id: '59511'
abstract:
- lang: eng
  text: <jats:title>Abstract</jats:title><jats:p>To minimize or avoid the use of antibiotics,
    antimicrobial polymers have emerged as a promising option to fight biomaterial‐associated
    infections, e.g., on titanium‐based implants. However, the challenge is to develop
    active polymers that exhibit an antimicrobial effect and are compatible with human
    cells. Different studies aiming for biocidal polymers active in soluble mode,
    focused on the ratio of cationic to hydrophobic groups, while only marginal knowledge
    is available for immobilized components. Here a strong hydrophilic electrolyte
    4‐vinylbenzyltrimethylammonium chloride (TMA) is chosen as the cationic component.
    The block composition of the polycationic segment is modified with styrene (Sty)
    regarding the amphiphilic balance. To adsorb such polymers onto titanium surfaces
    they are equipped with a polyphosphonic acid anchor block by sequential reversible‐addition‐fragmentation
    chain‐transfer polymerization (RAFT) polymerization. The polymer composition affected
    the wetting behavior of adsorbed coatings with water contact angles ranging from
    17° to 72°, while zetapotential measurements confirmed high extent of positive
    charges for all adsorbed polymer coatings. The fundamentally modified block composition
    resulted in significantly improved cytocompatibility. Antimicrobial efficacy in
    early bacterial adhesion is still retained from slightly antiadhesive coatings
    to combined antiadhesive/biocidal activity depending on Sty/TMA ratio in random
    polymers while a block copolymer revealed lowest antimicrobial effect.</jats:p>
author:
- first_name: Cornelia
  full_name: Wolf‐Brandstetter, Cornelia
  last_name: Wolf‐Brandstetter
- first_name: Rafael
  full_name: Methling, Rafael
  last_name: Methling
- first_name: Dirk
  full_name: Kuckling, Dirk
  id: '287'
  last_name: Kuckling
citation:
  ama: Wolf‐Brandstetter C, Methling R, Kuckling D. Adsorbable and Antimicrobial Amphiphilic
    Block Copolymers with Enhanced Biocompatibility. <i>Macromolecular Materials and
    Engineering</i>. Published online 2025. doi:<a href="https://doi.org/10.1002/mame.202500078">10.1002/mame.202500078</a>
  apa: Wolf‐Brandstetter, C., Methling, R., &#38; Kuckling, D. (2025). Adsorbable
    and Antimicrobial Amphiphilic Block Copolymers with Enhanced Biocompatibility.
    <i>Macromolecular Materials and Engineering</i>. <a href="https://doi.org/10.1002/mame.202500078">https://doi.org/10.1002/mame.202500078</a>
  bibtex: '@article{Wolf‐Brandstetter_Methling_Kuckling_2025, title={Adsorbable and
    Antimicrobial Amphiphilic Block Copolymers with Enhanced Biocompatibility}, DOI={<a
    href="https://doi.org/10.1002/mame.202500078">10.1002/mame.202500078</a>}, journal={Macromolecular
    Materials and Engineering}, publisher={Wiley}, author={Wolf‐Brandstetter, Cornelia
    and Methling, Rafael and Kuckling, Dirk}, year={2025} }'
  chicago: Wolf‐Brandstetter, Cornelia, Rafael Methling, and Dirk Kuckling. “Adsorbable
    and Antimicrobial Amphiphilic Block Copolymers with Enhanced Biocompatibility.”
    <i>Macromolecular Materials and Engineering</i>, 2025. <a href="https://doi.org/10.1002/mame.202500078">https://doi.org/10.1002/mame.202500078</a>.
  ieee: 'C. Wolf‐Brandstetter, R. Methling, and D. Kuckling, “Adsorbable and Antimicrobial
    Amphiphilic Block Copolymers with Enhanced Biocompatibility,” <i>Macromolecular
    Materials and Engineering</i>, 2025, doi: <a href="https://doi.org/10.1002/mame.202500078">10.1002/mame.202500078</a>.'
  mla: Wolf‐Brandstetter, Cornelia, et al. “Adsorbable and Antimicrobial Amphiphilic
    Block Copolymers with Enhanced Biocompatibility.” <i>Macromolecular Materials
    and Engineering</i>, Wiley, 2025, doi:<a href="https://doi.org/10.1002/mame.202500078">10.1002/mame.202500078</a>.
  short: C. Wolf‐Brandstetter, R. Methling, D. Kuckling, Macromolecular Materials
    and Engineering (2025).
date_created: 2025-04-11T07:35:39Z
date_updated: 2025-04-11T07:43:06Z
department:
- _id: '163'
doi: 10.1002/mame.202500078
keyword:
- antiadhesive surfaces
- antimicrobial polymers
- grafting to
- polymerbrushes
language:
- iso: eng
main_file_link:
- url: https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202500078
publication: Macromolecular Materials and Engineering
publication_identifier:
  issn:
  - 1438-7492
  - 1439-2054
publication_status: published
publisher: Wiley
status: public
title: Adsorbable and Antimicrobial Amphiphilic Block Copolymers with Enhanced Biocompatibility
type: journal_article
user_id: '94'
year: '2025'
...