---
_id: '59620'
article_type: original
author:
- first_name: Tarik
full_name: Rust, Tarik
last_name: Rust
- first_name: Dimitri
full_name: Jung, Dimitri
last_name: Jung
- first_name: Axel
full_name: Hoppe, Axel
id: '62844'
last_name: Hoppe
- first_name: Timo
full_name: Schoppa, Timo
last_name: Schoppa
- first_name: Klaus
full_name: Langer, Klaus
last_name: Langer
- first_name: Dirk
full_name: Kuckling, Dirk
id: '287'
last_name: Kuckling
citation:
ama: Rust T, Jung D, Hoppe A, Schoppa T, Langer K, Kuckling D. Backbone-Degradable
(Co-)Polymers for Light-Triggered Drug Delivery. ACS Applied Polymer Materials.
2021;3(8):3831-3842. doi:10.1021/acsapm.1c00411
apa: Rust, T., Jung, D., Hoppe, A., Schoppa, T., Langer, K., & Kuckling, D.
(2021). Backbone-Degradable (Co-)Polymers for Light-Triggered Drug Delivery. ACS
Applied Polymer Materials, 3(8), 3831–3842. https://doi.org/10.1021/acsapm.1c00411
bibtex: '@article{Rust_Jung_Hoppe_Schoppa_Langer_Kuckling_2021, title={Backbone-Degradable
(Co-)Polymers for Light-Triggered Drug Delivery}, volume={3}, DOI={10.1021/acsapm.1c00411},
number={8}, journal={ACS Applied Polymer Materials}, publisher={American Chemical
Society (ACS)}, author={Rust, Tarik and Jung, Dimitri and Hoppe, Axel and Schoppa,
Timo and Langer, Klaus and Kuckling, Dirk}, year={2021}, pages={3831–3842} }'
chicago: 'Rust, Tarik, Dimitri Jung, Axel Hoppe, Timo Schoppa, Klaus Langer, and
Dirk Kuckling. “Backbone-Degradable (Co-)Polymers for Light-Triggered Drug Delivery.”
ACS Applied Polymer Materials 3, no. 8 (2021): 3831–42. https://doi.org/10.1021/acsapm.1c00411.'
ieee: 'T. Rust, D. Jung, A. Hoppe, T. Schoppa, K. Langer, and D. Kuckling, “Backbone-Degradable
(Co-)Polymers for Light-Triggered Drug Delivery,” ACS Applied Polymer Materials,
vol. 3, no. 8, pp. 3831–3842, 2021, doi: 10.1021/acsapm.1c00411.'
mla: Rust, Tarik, et al. “Backbone-Degradable (Co-)Polymers for Light-Triggered
Drug Delivery.” ACS Applied Polymer Materials, vol. 3, no. 8, American
Chemical Society (ACS), 2021, pp. 3831–42, doi:10.1021/acsapm.1c00411.
short: T. Rust, D. Jung, A. Hoppe, T. Schoppa, K. Langer, D. Kuckling, ACS Applied
Polymer Materials 3 (2021) 3831–3842.
date_created: 2025-04-22T06:02:11Z
date_updated: 2025-04-22T06:12:02Z
department:
- _id: '311'
doi: 10.1021/acsapm.1c00411
intvolume: ' 3'
issue: '8'
keyword:
- backbone-degradable
- light-responsive
- redox-responsive
- drug delivery
- nanoparticles
language:
- iso: eng
main_file_link:
- url: https://pubs.acs.org/doi/10.1021/acsapm.1c00411?ref=PDF
page: 3831-3842
publication: ACS Applied Polymer Materials
publication_identifier:
issn:
- 2637-6105
- 2637-6105
publication_status: published
publisher: American Chemical Society (ACS)
quality_controlled: '1'
status: public
title: Backbone-Degradable (Co-)Polymers for Light-Triggered Drug Delivery
type: journal_article
user_id: '62844'
volume: 3
year: '2021'
...
---
_id: '30934'
author:
- first_name: Laura
full_name: Mahlert, Laura
last_name: Mahlert
- first_name: Juliane
full_name: Anderski, Juliane
last_name: Anderski
- first_name: Timo
full_name: Schoppa, Timo
last_name: Schoppa
- first_name: Dennis
full_name: Mulac, Dennis
last_name: Mulac
- first_name: Jingjiang
full_name: Sun, Jingjiang
last_name: Sun
- first_name: Dirk
full_name: Kuckling, Dirk
id: '287'
last_name: Kuckling
- first_name: Klaus
full_name: Langer, Klaus
last_name: Langer
citation:
ama: Mahlert L, Anderski J, Schoppa T, et al. In vitro evaluation of innovative
light-responsive nanoparticles for controlled drug release in intestinal PDT.
International Journal of Pharmaceutics. 2019;565:199-208. doi:10.1016/j.ijpharm.2019.04.077
apa: Mahlert, L., Anderski, J., Schoppa, T., Mulac, D., Sun, J., Kuckling, D., &
Langer, K. (2019). In vitro evaluation of innovative light-responsive nanoparticles
for controlled drug release in intestinal PDT. International Journal of Pharmaceutics,
565, 199–208. https://doi.org/10.1016/j.ijpharm.2019.04.077
bibtex: '@article{Mahlert_Anderski_Schoppa_Mulac_Sun_Kuckling_Langer_2019, title={In
vitro evaluation of innovative light-responsive nanoparticles for controlled drug
release in intestinal PDT}, volume={565}, DOI={10.1016/j.ijpharm.2019.04.077},
journal={International Journal of Pharmaceutics}, publisher={Elsevier BV}, author={Mahlert,
Laura and Anderski, Juliane and Schoppa, Timo and Mulac, Dennis and Sun, Jingjiang
and Kuckling, Dirk and Langer, Klaus}, year={2019}, pages={199–208} }'
chicago: 'Mahlert, Laura, Juliane Anderski, Timo Schoppa, Dennis Mulac, Jingjiang
Sun, Dirk Kuckling, and Klaus Langer. “In Vitro Evaluation of Innovative Light-Responsive
Nanoparticles for Controlled Drug Release in Intestinal PDT.” International
Journal of Pharmaceutics 565 (2019): 199–208. https://doi.org/10.1016/j.ijpharm.2019.04.077.'
ieee: 'L. Mahlert et al., “In vitro evaluation of innovative light-responsive
nanoparticles for controlled drug release in intestinal PDT,” International
Journal of Pharmaceutics, vol. 565, pp. 199–208, 2019, doi: 10.1016/j.ijpharm.2019.04.077.'
mla: Mahlert, Laura, et al. “In Vitro Evaluation of Innovative Light-Responsive
Nanoparticles for Controlled Drug Release in Intestinal PDT.” International
Journal of Pharmaceutics, vol. 565, Elsevier BV, 2019, pp. 199–208, doi:10.1016/j.ijpharm.2019.04.077.
short: L. Mahlert, J. Anderski, T. Schoppa, D. Mulac, J. Sun, D. Kuckling, K. Langer,
International Journal of Pharmaceutics 565 (2019) 199–208.
date_created: 2022-04-21T09:12:07Z
date_updated: 2022-04-21T09:13:07Z
department:
- _id: '311'
doi: 10.1016/j.ijpharm.2019.04.077
intvolume: ' 565'
keyword:
- Light-responsive polymersPhotodynamic therapyControlled drug deliveryHT-29-MTX cellsIntestinal
cancer
language:
- iso: eng
page: 199-208
publication: International Journal of Pharmaceutics
publication_identifier:
issn:
- 0378-5173
publication_status: published
publisher: Elsevier BV
status: public
title: In vitro evaluation of innovative light-responsive nanoparticles for controlled
drug release in intestinal PDT
type: journal_article
user_id: '94'
volume: 565
year: '2019'
...
---
_id: '30936'
author:
- first_name: Jingjiang
full_name: Sun, Jingjiang
last_name: Sun
- first_name: Dimitri
full_name: Jung, Dimitri
last_name: Jung
- first_name: Timo
full_name: Schoppa, Timo
last_name: Schoppa
- first_name: Juliane
full_name: Anderski, Juliane
last_name: Anderski
- first_name: Marie-Theres
full_name: Picker, Marie-Theres
last_name: Picker
- first_name: Yi
full_name: Ren, Yi
last_name: Ren
- first_name: Dennis
full_name: Mulac, Dennis
last_name: Mulac
- first_name: Nora
full_name: Stein, Nora
last_name: Stein
- first_name: Klaus
full_name: Langer, Klaus
last_name: Langer
- first_name: Dirk
full_name: Kuckling, Dirk
id: '287'
last_name: Kuckling
citation:
ama: Sun J, Jung D, Schoppa T, et al. Light-Responsive Serinol-Based Polycarbonate
and Polyester as Degradable Scaffolds. ACS Applied Bio Materials. 2019;2(7):3038-3051.
doi:10.1021/acsabm.9b00347
apa: Sun, J., Jung, D., Schoppa, T., Anderski, J., Picker, M.-T., Ren, Y., Mulac,
D., Stein, N., Langer, K., & Kuckling, D. (2019). Light-Responsive Serinol-Based
Polycarbonate and Polyester as Degradable Scaffolds. ACS Applied Bio Materials,
2(7), 3038–3051. https://doi.org/10.1021/acsabm.9b00347
bibtex: '@article{Sun_Jung_Schoppa_Anderski_Picker_Ren_Mulac_Stein_Langer_Kuckling_2019,
title={Light-Responsive Serinol-Based Polycarbonate and Polyester as Degradable
Scaffolds}, volume={2}, DOI={10.1021/acsabm.9b00347},
number={7}, journal={ACS Applied Bio Materials}, publisher={American Chemical
Society (ACS)}, author={Sun, Jingjiang and Jung, Dimitri and Schoppa, Timo and
Anderski, Juliane and Picker, Marie-Theres and Ren, Yi and Mulac, Dennis and Stein,
Nora and Langer, Klaus and Kuckling, Dirk}, year={2019}, pages={3038–3051} }'
chicago: 'Sun, Jingjiang, Dimitri Jung, Timo Schoppa, Juliane Anderski, Marie-Theres
Picker, Yi Ren, Dennis Mulac, Nora Stein, Klaus Langer, and Dirk Kuckling. “Light-Responsive
Serinol-Based Polycarbonate and Polyester as Degradable Scaffolds.” ACS Applied
Bio Materials 2, no. 7 (2019): 3038–51. https://doi.org/10.1021/acsabm.9b00347.'
ieee: 'J. Sun et al., “Light-Responsive Serinol-Based Polycarbonate and Polyester
as Degradable Scaffolds,” ACS Applied Bio Materials, vol. 2, no. 7, pp.
3038–3051, 2019, doi: 10.1021/acsabm.9b00347.'
mla: Sun, Jingjiang, et al. “Light-Responsive Serinol-Based Polycarbonate and Polyester
as Degradable Scaffolds.” ACS Applied Bio Materials, vol. 2, no. 7, American
Chemical Society (ACS), 2019, pp. 3038–51, doi:10.1021/acsabm.9b00347.
short: J. Sun, D. Jung, T. Schoppa, J. Anderski, M.-T. Picker, Y. Ren, D. Mulac,
N. Stein, K. Langer, D. Kuckling, ACS Applied Bio Materials 2 (2019) 3038–3051.
date_created: 2022-04-21T09:15:22Z
date_updated: 2022-04-21T09:16:31Z
department:
- _id: '311'
doi: 10.1021/acsabm.9b00347
intvolume: ' 2'
issue: '7'
keyword:
- light-responsive polymers
- biodegradable polymers
- polycondensation
language:
- iso: eng
page: 3038-3051
publication: ACS Applied Bio Materials
publication_identifier:
issn:
- 2576-6422
- 2576-6422
publication_status: published
publisher: American Chemical Society (ACS)
status: public
title: Light-Responsive Serinol-Based Polycarbonate and Polyester as Degradable Scaffolds
type: journal_article
user_id: '94'
volume: 2
year: '2019'
...
---
_id: '13186'
abstract:
- lang: eng
text: Ligands DMEG6etqu, TMG6etqu, DMEG6buqu, and TMG6buqu were developed on the
basis of guanidine quinoline (GUAqu) ligands 1,3-dimethyl-N-(quinolin-8-yl)imidazolidin-2-imine
(DMEGqu) and 1,1,3,3-tetramethyl-2-(quinolin-8-yl)guanidine (TMGqu). These ligands
feature an alkyl substituent at the C6 of the quinoline backbone. The synthetic
strategy developed here enables inexpensive syntheses of any kind of C6-substituted
GUAqu ligands. On one hand, the alkylation increases the solubility of corresponding
copper complexes in apolar atom transfer radical polymerization (ATRP) monomers
like styrene. On the other hand, it has a significant electronic influence and
thus an effect on the donor properties of the new ligands. Seven CuI and CuII
complexes of DMEG6etqu and TMG6etqu have been crystallized and were studied with
regard to their structural and electrochemical properties. CuI and CuII complexes
of DMEG6buqu and TMG6buqu turned out to be perfectly soluble in pure styrene even
at room temperature, which makes them excellent catalysts in the ATRP of apolar
monomers. The key characteristics of the ATRP equilibrium, KATRP and kact, were
determined for the new complexes. In addition, we used our recently developed
DFT methodology, NBO analysis, and isodesmic reactions to predict the influence
of the introduced alkyl substituents. It turned out that high conformational freedom
in the complex structures leads to a significant uncertainty in prediction of
the thermodynamic properties.
author:
- first_name: Thomas
full_name: Rösener, Thomas
last_name: Rösener
- first_name: Alexander
full_name: Hoffmann, Alexander
last_name: Hoffmann
- first_name: Sonja
full_name: Herres-Pawlis, Sonja
last_name: Herres-Pawlis
citation:
ama: 'Rösener T, Hoffmann A, Herres-Pawlis S. Next Generation of Guanidine Quinoline
Copper Complexes for Highly Controlled ATRP: Influence of Backbone Substitution
on Redox Chemistry and Solubility. European Journal of Inorganic Chemistry.
2018;2018(27):3164-3175. doi:10.1002/ejic.201800511'
apa: 'Rösener, T., Hoffmann, A., & Herres-Pawlis, S. (2018). Next Generation
of Guanidine Quinoline Copper Complexes for Highly Controlled ATRP: Influence
of Backbone Substitution on Redox Chemistry and Solubility. European Journal
of Inorganic Chemistry, 2018(27), 3164–3175. https://doi.org/10.1002/ejic.201800511'
bibtex: '@article{Rösener_Hoffmann_Herres-Pawlis_2018, title={Next Generation of
Guanidine Quinoline Copper Complexes for Highly Controlled ATRP: Influence of
Backbone Substitution on Redox Chemistry and Solubility}, volume={2018}, DOI={10.1002/ejic.201800511}, number={27},
journal={European Journal of Inorganic Chemistry}, author={Rösener, Thomas and
Hoffmann, Alexander and Herres-Pawlis, Sonja}, year={2018}, pages={3164–3175}
}'
chicago: 'Rösener, Thomas, Alexander Hoffmann, and Sonja Herres-Pawlis. “Next Generation
of Guanidine Quinoline Copper Complexes for Highly Controlled ATRP: Influence
of Backbone Substitution on Redox Chemistry and Solubility.” European Journal
of Inorganic Chemistry 2018, no. 27 (2018): 3164–75. https://doi.org/10.1002/ejic.201800511.'
ieee: 'T. Rösener, A. Hoffmann, and S. Herres-Pawlis, “Next Generation of Guanidine
Quinoline Copper Complexes for Highly Controlled ATRP: Influence of Backbone Substitution
on Redox Chemistry and Solubility,” European Journal of Inorganic Chemistry,
vol. 2018, no. 27, pp. 3164–3175, 2018.'
mla: 'Rösener, Thomas, et al. “Next Generation of Guanidine Quinoline Copper Complexes
for Highly Controlled ATRP: Influence of Backbone Substitution on Redox Chemistry
and Solubility.” European Journal of Inorganic Chemistry, vol. 2018, no.
27, 2018, pp. 3164–75, doi:10.1002/ejic.201800511.'
short: T. Rösener, A. Hoffmann, S. Herres-Pawlis, European Journal of Inorganic
Chemistry 2018 (2018) 3164–3175.
date_created: 2019-09-11T11:00:06Z
date_updated: 2022-01-06T06:51:30Z
doi: 10.1002/ejic.201800511
intvolume: ' 2018'
issue: '27'
keyword:
- Copper
- Polymerization
- Redox chemistry
- Structure elucidation
- Ligand effects
language:
- iso: eng
page: 3164-3175
project:
- _id: '52'
name: Computing Resources Provided by the Paderborn Center for Parallel Computing
publication: European Journal of Inorganic Chemistry
status: public
title: 'Next Generation of Guanidine Quinoline Copper Complexes for Highly Controlled
ATRP: Influence of Backbone Substitution on Redox Chemistry and Solubility'
type: journal_article
user_id: '40778'
volume: 2018
year: '2018'
...
---
_id: '30935'
author:
- first_name: Juliane
full_name: Anderski, Juliane
last_name: Anderski
- first_name: Laura
full_name: Mahlert, Laura
last_name: Mahlert
- first_name: Jingjiang
full_name: Sun, Jingjiang
last_name: Sun
- first_name: Wolfgang
full_name: Birnbaum, Wolfgang
last_name: Birnbaum
- first_name: Dennis
full_name: Mulac, Dennis
last_name: Mulac
- first_name: Sebastian
full_name: Schreiber, Sebastian
last_name: Schreiber
- first_name: Fabian
full_name: Herrmann, Fabian
last_name: Herrmann
- first_name: Dirk
full_name: Kuckling, Dirk
id: '287'
last_name: Kuckling
- first_name: Klaus
full_name: Langer, Klaus
last_name: Langer
citation:
ama: Anderski J, Mahlert L, Sun J, et al. Light-responsive nanoparticles based on
new polycarbonate polymers as innovative drug delivery systems for photosensitizers
in PDT. International Journal of Pharmaceutics. 2018;557:182-191. doi:10.1016/j.ijpharm.2018.12.040
apa: Anderski, J., Mahlert, L., Sun, J., Birnbaum, W., Mulac, D., Schreiber, S.,
Herrmann, F., Kuckling, D., & Langer, K. (2018). Light-responsive nanoparticles
based on new polycarbonate polymers as innovative drug delivery systems for photosensitizers
in PDT. International Journal of Pharmaceutics, 557, 182–191. https://doi.org/10.1016/j.ijpharm.2018.12.040
bibtex: '@article{Anderski_Mahlert_Sun_Birnbaum_Mulac_Schreiber_Herrmann_Kuckling_Langer_2018,
title={Light-responsive nanoparticles based on new polycarbonate polymers as innovative
drug delivery systems for photosensitizers in PDT}, volume={557}, DOI={10.1016/j.ijpharm.2018.12.040},
journal={International Journal of Pharmaceutics}, publisher={Elsevier BV}, author={Anderski,
Juliane and Mahlert, Laura and Sun, Jingjiang and Birnbaum, Wolfgang and Mulac,
Dennis and Schreiber, Sebastian and Herrmann, Fabian and Kuckling, Dirk and Langer,
Klaus}, year={2018}, pages={182–191} }'
chicago: 'Anderski, Juliane, Laura Mahlert, Jingjiang Sun, Wolfgang Birnbaum, Dennis
Mulac, Sebastian Schreiber, Fabian Herrmann, Dirk Kuckling, and Klaus Langer.
“Light-Responsive Nanoparticles Based on New Polycarbonate Polymers as Innovative
Drug Delivery Systems for Photosensitizers in PDT.” International Journal of
Pharmaceutics 557 (2018): 182–91. https://doi.org/10.1016/j.ijpharm.2018.12.040.'
ieee: 'J. Anderski et al., “Light-responsive nanoparticles based on new polycarbonate
polymers as innovative drug delivery systems for photosensitizers in PDT,” International
Journal of Pharmaceutics, vol. 557, pp. 182–191, 2018, doi: 10.1016/j.ijpharm.2018.12.040.'
mla: Anderski, Juliane, et al. “Light-Responsive Nanoparticles Based on New Polycarbonate
Polymers as Innovative Drug Delivery Systems for Photosensitizers in PDT.” International
Journal of Pharmaceutics, vol. 557, Elsevier BV, 2018, pp. 182–91, doi:10.1016/j.ijpharm.2018.12.040.
short: J. Anderski, L. Mahlert, J. Sun, W. Birnbaum, D. Mulac, S. Schreiber, F.
Herrmann, D. Kuckling, K. Langer, International Journal of Pharmaceutics 557 (2018)
182–191.
date_created: 2022-04-21T09:13:47Z
date_updated: 2022-04-21T09:14:49Z
department:
- _id: '311'
doi: 10.1016/j.ijpharm.2018.12.040
intvolume: ' 557'
keyword:
- NanoparticlesLight-responsive polymersPhotodynamic therapyPoly(lactic-co-glycolic
acid)Intestinal cancer
language:
- iso: eng
page: 182-191
publication: International Journal of Pharmaceutics
publication_identifier:
issn:
- 0378-5173
publication_status: published
publisher: Elsevier BV
status: public
title: Light-responsive nanoparticles based on new polycarbonate polymers as innovative
drug delivery systems for photosensitizers in PDT
type: journal_article
user_id: '94'
volume: 557
year: '2018'
...