---
_id: '32416'
abstract:
- lang: eng
  text: In recent years, sequence-defined oligomers (SDOs) gained increasing interest
    due to their perfectly controlled molecular structure, thus providing defined
    properties. In order to tune the properties, different functionalities need to
    be incorporated into the oligomers and the chain tacticity needs to be controlled.
    Beside the synthesis of SDOs, suitable methods need to be found to analyze the
    molecular structure. In this work, oligomers exhibiting an alternating or block-wise
    sequence of side chain functionalities were analyzed using a hyphenation of ultra-high-performance
    liquid chromatography and electrospray ionization mass spectrometry enhanced by
    ion mobility separation (IMS). Moieties in the side chains were varied according
    to polarity and bulkiness. Moreover, chain tacticity was varied. Drift times in
    the IMS cell and the corresponding collision cross section (CCS) values were shown
    to be individual parameters allowing the identification of SDOs, even in the case
    that SDO structures only differ in sequence or tacticity of side chain functionalities.
    Thus, a library of CCS values was obtained as reference used for the analysis
    of complex mixtures of SDOs.
article_type: original
author:
- first_name: Marie-Theres
  full_name: Berg, Marie-Theres
  last_name: Berg
- first_name: Artjom
  full_name: Herberg, Artjom
  id: '94'
  last_name: Herberg
- first_name: Dirk
  full_name: Kuckling, Dirk
  id: '287'
  last_name: Kuckling
citation:
  ama: Berg M-T, Herberg A, Kuckling D. Hyphenation of ultra-high-performance liquid
    chromatography and ion mobility mass spectrometry for the analysis of sequence-defined
    oligomers with different functionalities and tacticity. <i>International Journal
    of Polymer Analysis and Characterization</i>. Published online 2022:1-12. doi:<a
    href="https://doi.org/10.1080/1023666x.2022.2100968">10.1080/1023666x.2022.2100968</a>
  apa: Berg, M.-T., Herberg, A., &#38; Kuckling, D. (2022). Hyphenation of ultra-high-performance
    liquid chromatography and ion mobility mass spectrometry for the analysis of sequence-defined
    oligomers with different functionalities and tacticity. <i>International Journal
    of Polymer Analysis and Characterization</i>, 1–12. <a href="https://doi.org/10.1080/1023666x.2022.2100968">https://doi.org/10.1080/1023666x.2022.2100968</a>
  bibtex: '@article{Berg_Herberg_Kuckling_2022, title={Hyphenation of ultra-high-performance
    liquid chromatography and ion mobility mass spectrometry for the analysis of sequence-defined
    oligomers with different functionalities and tacticity}, DOI={<a href="https://doi.org/10.1080/1023666x.2022.2100968">10.1080/1023666x.2022.2100968</a>},
    journal={International Journal of Polymer Analysis and Characterization}, publisher={Informa
    UK Limited}, author={Berg, Marie-Theres and Herberg, Artjom and Kuckling, Dirk},
    year={2022}, pages={1–12} }'
  chicago: Berg, Marie-Theres, Artjom Herberg, and Dirk Kuckling. “Hyphenation of
    Ultra-High-Performance Liquid Chromatography and Ion Mobility Mass Spectrometry
    for the Analysis of Sequence-Defined Oligomers with Different Functionalities
    and Tacticity.” <i>International Journal of Polymer Analysis and Characterization</i>,
    2022, 1–12. <a href="https://doi.org/10.1080/1023666x.2022.2100968">https://doi.org/10.1080/1023666x.2022.2100968</a>.
  ieee: 'M.-T. Berg, A. Herberg, and D. Kuckling, “Hyphenation of ultra-high-performance
    liquid chromatography and ion mobility mass spectrometry for the analysis of sequence-defined
    oligomers with different functionalities and tacticity,” <i>International Journal
    of Polymer Analysis and Characterization</i>, pp. 1–12, 2022, doi: <a href="https://doi.org/10.1080/1023666x.2022.2100968">10.1080/1023666x.2022.2100968</a>.'
  mla: Berg, Marie-Theres, et al. “Hyphenation of Ultra-High-Performance Liquid Chromatography
    and Ion Mobility Mass Spectrometry for the Analysis of Sequence-Defined Oligomers
    with Different Functionalities and Tacticity.” <i>International Journal of Polymer
    Analysis and Characterization</i>, Informa UK Limited, 2022, pp. 1–12, doi:<a
    href="https://doi.org/10.1080/1023666x.2022.2100968">10.1080/1023666x.2022.2100968</a>.
  short: M.-T. Berg, A. Herberg, D. Kuckling, International Journal of Polymer Analysis
    and Characterization (2022) 1–12.
date_created: 2022-07-26T06:38:52Z
date_updated: 2023-01-10T08:14:52Z
department:
- _id: '163'
doi: 10.1080/1023666x.2022.2100968
keyword:
- Ultra-high-performance liquid chromatography
- ion mobility separation
- mass spectrometry
- LC-MS hyphenation
- sequence-defined oligomers
language:
- iso: eng
page: 1-12
publication: International Journal of Polymer Analysis and Characterization
publication_identifier:
  issn:
  - 1023-666X
  - 1563-5341
publication_status: published
publisher: Informa UK Limited
status: public
title: Hyphenation of ultra-high-performance liquid chromatography and ion mobility
  mass spectrometry for the analysis of sequence-defined oligomers with different
  functionalities and tacticity
type: journal_article
user_id: '94'
year: '2022'
...