@article{64884,
  abstract     = {{To address the challenges associated with poor drug solubility and uncontrolled drug release in conventional dosage forms, a combination of polymer design and advanced drug delivery approaches has been employed. The development of pH-responsive nanoparticles for controlled and selective drug release represents a notable advance in adaptive nanomedicine. This study explores the design of a pH-responsive polymer, poly(1,4-phenyleneacetone dimethylene ketal) (PPADK). Additionally, the incorporation of light-responsive ortho-nitrobenzyl groups (o-NB-PPADK) enhanced the degradation upon exposure to light. Based on the polymer, nanoparticles were prepared using the solvent displacement method. The fluorescence dye Lumogen® Red was incorporated as a model substance. The nanoparticles were characterized by dynamic light scattering to determine their hydrodynamic diameter and size distribution, and the surface charge was analyzed. Atomic force microscopy was used to visualize the surface morphology. The nanoparticles remained stable under physiological pH conditions while exhibiting accelerated degradation and substance release in acidic environment, a property potentially exploitable for tumor targeting. Further enhanced degradation and correspondingly increased release was achieved by incorporating light-responsive elements in the polymer structure.
The cytotoxicity of these newly designed nanoparticles was evaluated in cell culture using a breast cancer cell line. These results support the potential of o-NB-PPADK nanoparticles as a possible candidate for selective and effective cancer therapy, combining stimuli-responsive degradation mechanisms for improved therapeutic outcomes.}},
  author       = {{Kramer, Maurice and van der Linde, Matthias and Hönscheid, Lisa and Horky, Corinna and Völlmecke, Katharina and Mulac, Dennis and Herrmann, Fabian and Kuckling, Dirk and Langer, Klaus}},
  issn         = {{0378-5173}},
  journal      = {{International Journal of Pharmaceutics}},
  keywords     = {{Nanoparticles, Drug delivery, Controlled release, Stimuli-responsiveTumor targeting}},
  publisher    = {{Elsevier BV}},
  title        = {{{Enlightening release strategies: Accelerated nanoparticle degradation and substance release utilizing light- and pH-responsive polymers}}},
  doi          = {{10.1016/j.ijpharm.2025.126127}},
  volume       = {{684}},
  year         = {{2025}},
}

@article{35657,
  abstract     = {{The controlled delivery of active pharmaceutical ingredients to the site of disease represents a major challenge in drug therapy. Particularly when drugs have to be transported across biological barriers, suitable drug delivery systems are of importance. In recent years responsive delivery systems have been developed which enable a controlled drug release depending on internal or external stimuli such as changes in pH, redox environment or light and temperature. In some studies delivery systems with reactivity against two different stimuli were established either to enhance the response by synergies of the stimuli or to broaden the window of possible trigger events. In the present review numerous exciting developments of pH-, light- and redox-cleavable polymers suitable for the preparation of smart delivery systems are described. The review discusses the different stimuli that can be used for a controlled drug release of polymer-based delivery systems. It puts a focus on the different polymers described for the preparation of stimuli-sensitive systems, their preparation techniques as well as their stimuli-responsive degradation. © 2022 The Authors. Polymer International published by John Wiley & Sons Ltd on behalf of Society of Industrial Chemistry.}},
  author       = {{Rust, Tarik and Jung, Dimitri and Langer, Klaus and Kuckling, Dirk}},
  issn         = {{0959-8103}},
  journal      = {{Polymer International}},
  keywords     = {{drug delivery system, stimuli, polymer, cleavable}},
  number       = {{1}},
  pages        = {{5--19}},
  publisher    = {{Wiley}},
  title        = {{{Stimuli‐accelerated polymeric drug delivery systems}}},
  doi          = {{10.1002/pi.6474}},
  volume       = {{72}},
  year         = {{2023}},
}

@inproceedings{9850,
  abstract     = {{A business model describes the mechanisms whereby a firm creates, delivers, and captures value. Following the steadily growing interest in business model innovation, software tools have shown great potential in supporting business model development and innovation. Yet, understanding the cognitive processes involved in the generation of business model ideas is an aspect of software design-knowledge that has so far been neglected. To investigate whether providing stimuli – in this case, brainstorming questions – can enhance individual creativity in this context, we conduct an exploratory experiment with over 100 participants. Our study is the first to systematically investigate the process of idea generation using a software-based business model development tool with stimuli. Our preliminary findings have the potential to support the future development of business model development tools and to refine the research design used to evaluate such tools.}},
  author       = {{Szopinski, Daniel}},
  booktitle    = {{Proceedings of the ACM Creativity & Cognition}},
  keywords     = {{Business model innovation, idea generation, cognitive stimuli, business model development tools, experiment, creativity support system}},
  location     = {{San Diego, USA}},
  title        = {{{Can stimuli improve business model idea generation? Developing software-based tools for business model innovation}}},
  year         = {{2019}},
}

@article{6066,
  abstract     = {{Selective visual attention improves performance in many tasks. Among others, it leads to 'prior entry'—earlier perception of an attended compared to an unattended stimulus. Whether this phenomenon is purely based on an increase of the processing rate of the attended stimulus or if a decrease in the processing rate of the unattended stimulus also contributes to the effect is, up to now, unanswered. Here we describe a novel approach to this question based on Bundesen’s Theory of Visual Attention, which we use to overcome the limitations of earlier prior-entry assessment with temporal order judgments (TOJs) that only allow relative statements regarding the processing speed of attended and unattended stimuli. Prevalent models of prior entry in TOJs either indirectly predict a pure acceleration or cannot model the difference between acceleration and deceleration. In a paradigm that combines a letter-identification task with TOJs, we show that indeed acceleration of the attended and deceler}},
  author       = {{Tünnermann, Jan and Petersen, Anders and Scharlau, Ingrid}},
  issn         = {{1534-7362}},
  journal      = {{Journal of Vision}},
  keywords     = {{unattended stimuli, attention speed, cognitive processing, Attention, Humans, Judgment, Mental Recall, Visual Perception, Stimulus Parameters, Visual Perception, Visual Attention, Cognitive Processes, Velocity}},
  number       = {{3}},
  title        = {{{Does attention speed up processing? Decreases and increases of processing rates in visual prior entry.}}},
  doi          = {{10.1167/15.3.1}},
  volume       = {{15}},
  year         = {{2015}},
}

@article{6065,
  abstract     = {{In the direct parameter specification (DPS) mode of sensorimotor control, response parameters can be specified by stimuli that are not consciously perceived [Psychological Research/Psychologische Forschung 52 (1990) 207]. DPS is contingent on the current intentions. The invisible stimuli can be processed for the purposes of sensorimotor control only if they match the actual intentions, for example, share task-relevant features. The present experiments explore whether attentional capture by masked abrupt-onset stimuli is mediated via DPS. Participants judged which of two visual targets appeared first. Masked primes preceded one of the targets. The primes were either similar to the targets or not, in shape, or in color. Target-like (task-relevant), but not distractor-like (task-irrelevant), primes facilitated perceptual latencies of targets trailing at their positions. Thus, the latency effects resulted from DPS of an attention shift, rather than from bottom-up capture or from top-down }},
  author       = {{Scharlau, Ingrid and Ansorge, Ulrich}},
  issn         = {{0042-6989}},
  journal      = {{Vision Research}},
  keywords     = {{direct parameter specification, DPS, attention shift, latency priming, sensorimotor control, stimuli, task-relevant features, visual targets, color, shape, latency effects, Adult, Attention, Discrimination (Psychology), Female, Humans, Judgment, Male, Perceptual Masking, Reaction Time, Visual Perception, Attention, Perceptual Motor Processes, Response Latency, Stimulus Onset, Visual Stimulation, Form and Shape Perception, Sensory Adaptation}},
  number       = {{12}},
  pages        = {{1351 -- 1363}},
  title        = {{{Direct parameter specification of an attention shift: Evidence from perceptual latency priming.}}},
  volume       = {{43}},
  year         = {{2003}},
}

@article{6078,
  abstract     = {{Four experiments investigated the influence of a metacontrast-masked prime on temporal order judgments. The main results were (1) that a masked prime reduced the latency of the mask's conscious perception (perceptual latency priming), (2) that this effect was independent of whether the prime suffered strong or weak masking, (3) that it was unaffected by the degree of visual similarity between the prime and the mask, and that (4) there was no difference between congruent and incongruent primes. Finding (1) suggests that location cueing affects not only response times but also the latency of conscious perception. (2) The finding that priming was unaffected by the prime's detectability argues against a response bias interpretation of this effect. (3) Since visual similarity had no effect on the prime's efficiency, it is unlikely that sensory priming was involved. (4) The lack of a divergence between the effects of congruent and incongruent primes implies a functional difference between t}},
  author       = {{Scharlau, Ingrid and Neumann, Odmar}},
  issn         = {{0340-0727}},
  journal      = {{Psychological Research}},
  keywords     = {{perceptual latency priming, temporal order judgments, masked stimuli, unmasked stimuli, attentional interpretation, response times, location cueing, visual perception, Adult, Attention, Female, Humans, Male, Models, Psychological, Perceptual Masking, Psychometrics, Reaction Time, Task Performance and Analysis, Time Perception, Masking, Reaction Time, Response Latency, Stimulus Parameters, Visual Contrast, Attention, Cues, Priming, Temporal Frequency, Temporal Order (Judgment)}},
  number       = {{3}},
  pages        = {{184 -- 196}},
  title        = {{{Perceptual latency priming by masked and unmasked stimuli: Evidence for an attentional interpretation.}}},
  volume       = {{67}},
  year         = {{2003}},
}