---
_id: '64884'
abstract:
- lang: eng
text: "To address the challenges associated with poor drug solubility and uncontrolled
drug release in conventional dosage forms, a combination of polymer design and
advanced drug delivery approaches has been employed. The development of pH-responsive
nanoparticles for controlled and selective drug release represents a notable advance
in adaptive nanomedicine. This study explores the design of a pH-responsive polymer,
poly(1,4-phenyleneacetone dimethylene ketal) (PPADK). Additionally, the incorporation
of light-responsive ortho-nitrobenzyl groups (o-NB-PPADK) enhanced the degradation
upon exposure to light. Based on the polymer, nanoparticles were prepared using
the solvent displacement method. The fluorescence dye Lumogen® Red was incorporated
as a model substance. The nanoparticles were characterized by dynamic light scattering
to determine their hydrodynamic diameter and size distribution, and the surface
charge was analyzed. Atomic force microscopy was used to visualize the surface
morphology. The nanoparticles remained stable under physiological pH conditions
while exhibiting accelerated degradation and substance release in acidic environment,
a property potentially exploitable for tumor targeting. Further enhanced degradation
and correspondingly increased release was achieved by incorporating light-responsive
elements in the polymer structure.\r\nThe cytotoxicity of these newly designed
nanoparticles was evaluated in cell culture using a breast cancer cell line. These
results support the potential of o-NB-PPADK nanoparticles as a possible candidate
for selective and effective cancer therapy, combining stimuli-responsive degradation
mechanisms for improved therapeutic outcomes."
article_number: '126127'
article_type: original
author:
- first_name: Maurice
full_name: Kramer, Maurice
last_name: Kramer
- first_name: Matthias
full_name: van der Linde, Matthias
last_name: van der Linde
- first_name: Lisa
full_name: Hönscheid, Lisa
last_name: Hönscheid
- first_name: Corinna
full_name: Horky, Corinna
last_name: Horky
- first_name: Katharina
full_name: Völlmecke, Katharina
last_name: Völlmecke
- first_name: Dennis
full_name: Mulac, Dennis
last_name: Mulac
- first_name: Fabian
full_name: Herrmann, Fabian
last_name: Herrmann
- first_name: Dirk
full_name: Kuckling, Dirk
id: '287'
last_name: Kuckling
- first_name: Klaus
full_name: Langer, Klaus
last_name: Langer
citation:
ama: 'Kramer M, van der Linde M, Hönscheid L, et al. Enlightening release strategies:
Accelerated nanoparticle degradation and substance release utilizing light- and
pH-responsive polymers. International Journal of Pharmaceutics. 2025;684.
doi:10.1016/j.ijpharm.2025.126127'
apa: 'Kramer, M., van der Linde, M., Hönscheid, L., Horky, C., Völlmecke, K., Mulac,
D., Herrmann, F., Kuckling, D., & Langer, K. (2025). Enlightening release
strategies: Accelerated nanoparticle degradation and substance release utilizing
light- and pH-responsive polymers. International Journal of Pharmaceutics,
684, Article 126127. https://doi.org/10.1016/j.ijpharm.2025.126127'
bibtex: '@article{Kramer_van der Linde_Hönscheid_Horky_Völlmecke_Mulac_Herrmann_Kuckling_Langer_2025,
title={Enlightening release strategies: Accelerated nanoparticle degradation and
substance release utilizing light- and pH-responsive polymers}, volume={684},
DOI={10.1016/j.ijpharm.2025.126127},
number={126127}, journal={International Journal of Pharmaceutics}, publisher={Elsevier
BV}, author={Kramer, Maurice and van der Linde, Matthias and Hönscheid, Lisa and
Horky, Corinna and Völlmecke, Katharina and Mulac, Dennis and Herrmann, Fabian
and Kuckling, Dirk and Langer, Klaus}, year={2025} }'
chicago: 'Kramer, Maurice, Matthias van der Linde, Lisa Hönscheid, Corinna Horky,
Katharina Völlmecke, Dennis Mulac, Fabian Herrmann, Dirk Kuckling, and Klaus Langer.
“Enlightening Release Strategies: Accelerated Nanoparticle Degradation and Substance
Release Utilizing Light- and PH-Responsive Polymers.” International Journal
of Pharmaceutics 684 (2025). https://doi.org/10.1016/j.ijpharm.2025.126127.'
ieee: 'M. Kramer et al., “Enlightening release strategies: Accelerated nanoparticle
degradation and substance release utilizing light- and pH-responsive polymers,”
International Journal of Pharmaceutics, vol. 684, Art. no. 126127, 2025,
doi: 10.1016/j.ijpharm.2025.126127.'
mla: 'Kramer, Maurice, et al. “Enlightening Release Strategies: Accelerated Nanoparticle
Degradation and Substance Release Utilizing Light- and PH-Responsive Polymers.”
International Journal of Pharmaceutics, vol. 684, 126127, Elsevier BV,
2025, doi:10.1016/j.ijpharm.2025.126127.'
short: M. Kramer, M. van der Linde, L. Hönscheid, C. Horky, K. Völlmecke, D. Mulac,
F. Herrmann, D. Kuckling, K. Langer, International Journal of Pharmaceutics 684
(2025).
date_created: 2026-03-11T08:46:17Z
date_updated: 2026-03-11T08:52:22Z
department:
- _id: '163'
doi: 10.1016/j.ijpharm.2025.126127
intvolume: ' 684'
keyword:
- Nanoparticles
- Drug delivery
- Controlled release
- Stimuli-responsiveTumor targeting
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/S0378517325009640?via%3Dihub
publication: International Journal of Pharmaceutics
publication_identifier:
issn:
- 0378-5173
publication_status: published
publisher: Elsevier BV
status: public
title: 'Enlightening release strategies: Accelerated nanoparticle degradation and
substance release utilizing light- and pH-responsive polymers'
type: journal_article
user_id: '94'
volume: 684
year: '2025'
...
---
_id: '35657'
abstract:
- lang: eng
text: The controlled delivery of active pharmaceutical ingredients to the site of
disease represents a major challenge in drug therapy. Particularly when drugs
have to be transported across biological barriers, suitable drug delivery systems
are of importance. In recent years responsive delivery systems have been developed
which enable a controlled drug release depending on internal or external stimuli
such as changes in pH, redox environment or light and temperature. In some studies
delivery systems with reactivity against two different stimuli were established
either to enhance the response by synergies of the stimuli or to broaden the window
of possible trigger events. In the present review numerous exciting developments
of pH-, light- and redox-cleavable polymers suitable for the preparation of smart
delivery systems are described. The review discusses the different stimuli that
can be used for a controlled drug release of polymer-based delivery systems. It
puts a focus on the different polymers described for the preparation of stimuli-sensitive
systems, their preparation techniques as well as their stimuli-responsive degradation.
© 2022 The Authors. Polymer International published by John Wiley & Sons Ltd on
behalf of Society of Industrial Chemistry.
article_type: original
author:
- first_name: Tarik
full_name: Rust, Tarik
last_name: Rust
- first_name: Dimitri
full_name: Jung, Dimitri
last_name: Jung
- first_name: Klaus
full_name: Langer, Klaus
last_name: Langer
- first_name: Dirk
full_name: Kuckling, Dirk
id: '287'
last_name: Kuckling
citation:
ama: Rust T, Jung D, Langer K, Kuckling D. Stimuli‐accelerated polymeric drug delivery
systems. Polymer International. 2023;72(1):5-19. doi:10.1002/pi.6474
apa: Rust, T., Jung, D., Langer, K., & Kuckling, D. (2023). Stimuli‐accelerated
polymeric drug delivery systems. Polymer International, 72(1), 5–19.
https://doi.org/10.1002/pi.6474
bibtex: '@article{Rust_Jung_Langer_Kuckling_2023, title={Stimuli‐accelerated polymeric
drug delivery systems}, volume={72}, DOI={10.1002/pi.6474},
number={1}, journal={Polymer International}, publisher={Wiley}, author={Rust,
Tarik and Jung, Dimitri and Langer, Klaus and Kuckling, Dirk}, year={2023}, pages={5–19}
}'
chicago: 'Rust, Tarik, Dimitri Jung, Klaus Langer, and Dirk Kuckling. “Stimuli‐accelerated
Polymeric Drug Delivery Systems.” Polymer International 72, no. 1 (2023):
5–19. https://doi.org/10.1002/pi.6474.'
ieee: 'T. Rust, D. Jung, K. Langer, and D. Kuckling, “Stimuli‐accelerated polymeric
drug delivery systems,” Polymer International, vol. 72, no. 1, pp. 5–19,
2023, doi: 10.1002/pi.6474.'
mla: Rust, Tarik, et al. “Stimuli‐accelerated Polymeric Drug Delivery Systems.”
Polymer International, vol. 72, no. 1, Wiley, 2023, pp. 5–19, doi:10.1002/pi.6474.
short: T. Rust, D. Jung, K. Langer, D. Kuckling, Polymer International 72 (2023)
5–19.
date_created: 2023-01-10T08:25:22Z
date_updated: 2023-01-10T08:31:31Z
department:
- _id: '163'
doi: 10.1002/pi.6474
intvolume: ' 72'
issue: '1'
keyword:
- drug delivery system
- stimuli
- polymer
- cleavable
language:
- iso: eng
main_file_link:
- url: https://onlinelibrary.wiley.com/doi/10.1002/pi.6474
page: 5-19
publication: Polymer International
publication_identifier:
issn:
- 0959-8103
- 1097-0126
publication_status: published
publisher: Wiley
status: public
title: Stimuli‐accelerated polymeric drug delivery systems
type: journal_article
user_id: '94'
volume: 72
year: '2023'
...
---
_id: '9850'
abstract:
- lang: eng
text: A business model describes the mechanisms whereby a firm creates, delivers,
and captures value. Following the steadily growing interest in business model
innovation, software tools have shown great potential in supporting business model
development and innovation. Yet, understanding the cognitive processes involved
in the generation of business model ideas is an aspect of software design-knowledge
that has so far been neglected. To investigate whether providing stimuli – in
this case, brainstorming questions – can enhance individual creativity in this
context, we conduct an exploratory experiment with over 100 participants. Our
study is the first to systematically investigate the process of idea generation
using a software-based business model development tool with stimuli. Our preliminary
findings have the potential to support the future development of business model
development tools and to refine the research design used to evaluate such tools.
accept: '1'
author:
- first_name: Daniel
full_name: Szopinski, Daniel
id: '36372'
last_name: Szopinski
citation:
ama: 'Szopinski D. Can stimuli improve business model idea generation? Developing
software-based tools for business model innovation. In: Proceedings of the
ACM Creativity & Cognition. ; 2019.'
apa: Szopinski, D. (2019). Can stimuli improve business model idea generation? Developing
software-based tools for business model innovation. In Proceedings of the ACM
Creativity & Cognition. San Diego, USA.
bibtex: '@inproceedings{Szopinski_2019, title={Can stimuli improve business model
idea generation? Developing software-based tools for business model innovation},
booktitle={Proceedings of the ACM Creativity & Cognition}, author={Szopinski,
Daniel}, year={2019} }'
chicago: Szopinski, Daniel. “Can Stimuli Improve Business Model Idea Generation?
Developing Software-Based Tools for Business Model Innovation.” In Proceedings
of the ACM Creativity & Cognition, 2019.
ieee: D. Szopinski, “Can stimuli improve business model idea generation? Developing
software-based tools for business model innovation,” in Proceedings of the
ACM Creativity & Cognition, San Diego, USA, 2019.
mla: Szopinski, Daniel. “Can Stimuli Improve Business Model Idea Generation? Developing
Software-Based Tools for Business Model Innovation.” Proceedings of the ACM
Creativity & Cognition, 2019.
short: 'D. Szopinski, in: Proceedings of the ACM Creativity & Cognition, 2019.'
conference:
location: San Diego, USA
name: ACM Creativity & Cognition 2019
date_created: 2019-05-20T09:59:01Z
date_updated: 2019-10-17T06:58:46Z
ddc:
- '330'
department:
- _id: '276'
file:
- access_level: closed
content_type: application/pdf
creator: dsz
date_created: 2019-10-17T06:58:40Z
date_updated: 2019-10-17T06:58:40Z
file_id: '13899'
file_name: p547-szopinski(1).pdf
file_size: 1005738
relation: main_file
success: 1
file_date_updated: 2019-10-17T06:58:40Z
keyword:
- Business model innovation
- idea generation
- cognitive stimuli
- business model development tools
- experiment
- creativity support system
language:
- iso: eng
project:
- _id: '1'
name: SFB 901
- _id: '4'
name: SFB 901 - Project Area C
- _id: '17'
name: SFB 901 - Subproject C5
publication: Proceedings of the ACM Creativity & Cognition
status: public
title: Can stimuli improve business model idea generation? Developing software-based
tools for business model innovation
type: conference
user_id: '36372'
year: '2019'
...
---
_id: '6066'
abstract:
- lang: eng
text: Selective visual attention improves performance in many tasks. Among others,
it leads to 'prior entry'—earlier perception of an attended compared to an unattended
stimulus. Whether this phenomenon is purely based on an increase of the processing
rate of the attended stimulus or if a decrease in the processing rate of the unattended
stimulus also contributes to the effect is, up to now, unanswered. Here we describe
a novel approach to this question based on Bundesen’s Theory of Visual Attention,
which we use to overcome the limitations of earlier prior-entry assessment with
temporal order judgments (TOJs) that only allow relative statements regarding
the processing speed of attended and unattended stimuli. Prevalent models of prior
entry in TOJs either indirectly predict a pure acceleration or cannot model the
difference between acceleration and deceleration. In a paradigm that combines
a letter-identification task with TOJs, we show that indeed acceleration of the
attended and deceler
author:
- first_name: Jan
full_name: Tünnermann, Jan
last_name: Tünnermann
- first_name: Anders
full_name: Petersen, Anders
last_name: Petersen
- first_name: Ingrid
full_name: Scharlau, Ingrid
id: '451'
last_name: Scharlau
orcid: 0000-0003-2364-9489
citation:
ama: Tünnermann J, Petersen A, Scharlau I. Does attention speed up processing? Decreases
and increases of processing rates in visual prior entry. Journal of Vision.
2015;15(3). doi:10.1167/15.3.1
apa: Tünnermann, J., Petersen, A., & Scharlau, I. (2015). Does attention speed
up processing? Decreases and increases of processing rates in visual prior entry.
Journal of Vision, 15(3). https://doi.org/10.1167/15.3.1
bibtex: '@article{Tünnermann_Petersen_Scharlau_2015, title={Does attention speed
up processing? Decreases and increases of processing rates in visual prior entry.},
volume={15}, DOI={10.1167/15.3.1},
number={3}, journal={Journal of Vision}, author={Tünnermann, Jan and Petersen,
Anders and Scharlau, Ingrid}, year={2015} }'
chicago: Tünnermann, Jan, Anders Petersen, and Ingrid Scharlau. “Does Attention
Speed up Processing? Decreases and Increases of Processing Rates in Visual Prior
Entry.” Journal of Vision 15, no. 3 (2015). https://doi.org/10.1167/15.3.1.
ieee: 'J. Tünnermann, A. Petersen, and I. Scharlau, “Does attention speed up processing?
Decreases and increases of processing rates in visual prior entry.,” Journal
of Vision, vol. 15, no. 3, 2015, doi: 10.1167/15.3.1.'
mla: Tünnermann, Jan, et al. “Does Attention Speed up Processing? Decreases and
Increases of Processing Rates in Visual Prior Entry.” Journal of Vision,
vol. 15, no. 3, 2015, doi:10.1167/15.3.1.
short: J. Tünnermann, A. Petersen, I. Scharlau, Journal of Vision 15 (2015).
date_created: 2018-12-10T07:01:56Z
date_updated: 2022-06-06T16:31:07Z
department:
- _id: '424'
doi: 10.1167/15.3.1
intvolume: ' 15'
issue: '3'
keyword:
- unattended stimuli
- attention speed
- cognitive processing
- Attention
- Humans
- Judgment
- Mental Recall
- Visual Perception
- Stimulus Parameters
- Visual Perception
- Visual Attention
- Cognitive Processes
- Velocity
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://jov.arvojournals.org/article.aspx?articleid=2213282
oa: '1'
publication: Journal of Vision
publication_identifier:
issn:
- 1534-7362
publication_status: published
status: public
title: Does attention speed up processing? Decreases and increases of processing rates
in visual prior entry.
type: journal_article
user_id: '42165'
volume: 15
year: '2015'
...
---
_id: '6065'
abstract:
- lang: eng
text: 'In the direct parameter specification (DPS) mode of sensorimotor control,
response parameters can be specified by stimuli that are not consciously perceived
[Psychological Research/Psychologische Forschung 52 (1990) 207]. DPS is contingent
on the current intentions. The invisible stimuli can be processed for the purposes
of sensorimotor control only if they match the actual intentions, for example,
share task-relevant features. The present experiments explore whether attentional
capture by masked abrupt-onset stimuli is mediated via DPS. Participants judged
which of two visual targets appeared first. Masked primes preceded one of the
targets. The primes were either similar to the targets or not, in shape, or in
color. Target-like (task-relevant), but not distractor-like (task-irrelevant),
primes facilitated perceptual latencies of targets trailing at their positions.
Thus, the latency effects resulted from DPS of an attention shift, rather than
from bottom-up capture or from top-down '
author:
- first_name: Ingrid
full_name: Scharlau, Ingrid
id: '451'
last_name: Scharlau
orcid: 0000-0003-2364-9489
- first_name: Ulrich
full_name: Ansorge, Ulrich
last_name: Ansorge
citation:
ama: 'Scharlau I, Ansorge U. Direct parameter specification of an attention shift:
Evidence from perceptual latency priming. Vision Research. 2003;43(12):1351-1363.'
apa: 'Scharlau, I., & Ansorge, U. (2003). Direct parameter specification of
an attention shift: Evidence from perceptual latency priming. Vision Research,
43(12), 1351–1363.'
bibtex: '@article{Scharlau_Ansorge_2003, title={Direct parameter specification of
an attention shift: Evidence from perceptual latency priming.}, volume={43}, number={12},
journal={Vision Research}, author={Scharlau, Ingrid and Ansorge, Ulrich}, year={2003},
pages={1351–1363} }'
chicago: 'Scharlau, Ingrid, and Ulrich Ansorge. “Direct Parameter Specification
of an Attention Shift: Evidence from Perceptual Latency Priming.” Vision Research
43, no. 12 (2003): 1351–63.'
ieee: 'I. Scharlau and U. Ansorge, “Direct parameter specification of an attention
shift: Evidence from perceptual latency priming.,” Vision Research, vol.
43, no. 12, pp. 1351–1363, 2003.'
mla: 'Scharlau, Ingrid, and Ulrich Ansorge. “Direct Parameter Specification of an
Attention Shift: Evidence from Perceptual Latency Priming.” Vision Research,
vol. 43, no. 12, 2003, pp. 1351–63.'
short: I. Scharlau, U. Ansorge, Vision Research 43 (2003) 1351–1363.
date_created: 2018-12-10T07:01:37Z
date_updated: 2022-06-07T00:26:34Z
department:
- _id: '424'
extern: '1'
intvolume: ' 43'
issue: '12'
keyword:
- direct parameter specification
- DPS
- attention shift
- latency priming
- sensorimotor control
- stimuli
- task-relevant features
- visual targets
- color
- shape
- latency effects
- Adult
- Attention
- Discrimination (Psychology)
- Female
- Humans
- Judgment
- Male
- Perceptual Masking
- Reaction Time
- Visual Perception
- Attention
- Perceptual Motor Processes
- Response Latency
- Stimulus Onset
- Visual Stimulation
- Form and Shape Perception
- Sensory Adaptation
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://kw.uni-paderborn.de/fileadmin/fakultaet/Institute/psychologie/Kognitive_Psychologie/Publikationen/ScharlauAnsorge2003VisResDPS.pdf
oa: '1'
page: 1351 - 1363
publication: Vision Research
publication_identifier:
issn:
- 0042-6989
publication_status: published
status: public
title: 'Direct parameter specification of an attention shift: Evidence from perceptual
latency priming.'
type: journal_article
user_id: '42165'
volume: 43
year: '2003'
...
---
_id: '6078'
abstract:
- lang: eng
text: Four experiments investigated the influence of a metacontrast-masked prime
on temporal order judgments. The main results were (1) that a masked prime reduced
the latency of the mask's conscious perception (perceptual latency priming), (2)
that this effect was independent of whether the prime suffered strong or weak
masking, (3) that it was unaffected by the degree of visual similarity between
the prime and the mask, and that (4) there was no difference between congruent
and incongruent primes. Finding (1) suggests that location cueing affects not
only response times but also the latency of conscious perception. (2) The finding
that priming was unaffected by the prime's detectability argues against a response
bias interpretation of this effect. (3) Since visual similarity had no effect
on the prime's efficiency, it is unlikely that sensory priming was involved. (4)
The lack of a divergence between the effects of congruent and incongruent primes
implies a functional difference between t
author:
- first_name: Ingrid
full_name: Scharlau, Ingrid
id: '451'
last_name: Scharlau
orcid: 0000-0003-2364-9489
- first_name: Odmar
full_name: Neumann, Odmar
last_name: Neumann
citation:
ama: 'Scharlau I, Neumann O. Perceptual latency priming by masked and unmasked stimuli:
Evidence for an attentional interpretation. Psychological Research. 2003;67(3):184-196.'
apa: 'Scharlau, I., & Neumann, O. (2003). Perceptual latency priming by masked
and unmasked stimuli: Evidence for an attentional interpretation. Psychological
Research, 67(3), 184–196.'
bibtex: '@article{Scharlau_Neumann_2003, title={Perceptual latency priming by masked
and unmasked stimuli: Evidence for an attentional interpretation.}, volume={67},
number={3}, journal={Psychological Research}, author={Scharlau, Ingrid and Neumann,
Odmar}, year={2003}, pages={184–196} }'
chicago: 'Scharlau, Ingrid, and Odmar Neumann. “Perceptual Latency Priming by Masked
and Unmasked Stimuli: Evidence for an Attentional Interpretation.” Psychological
Research 67, no. 3 (2003): 184–96.'
ieee: 'I. Scharlau and O. Neumann, “Perceptual latency priming by masked and unmasked
stimuli: Evidence for an attentional interpretation.,” Psychological Research,
vol. 67, no. 3, pp. 184–196, 2003.'
mla: 'Scharlau, Ingrid, and Odmar Neumann. “Perceptual Latency Priming by Masked
and Unmasked Stimuli: Evidence for an Attentional Interpretation.” Psychological
Research, vol. 67, no. 3, 2003, pp. 184–96.'
short: I. Scharlau, O. Neumann, Psychological Research 67 (2003) 184–196.
date_created: 2018-12-10T07:05:43Z
date_updated: 2022-06-07T00:27:08Z
department:
- _id: '424'
extern: '1'
intvolume: ' 67'
issue: '3'
keyword:
- perceptual latency priming
- temporal order judgments
- masked stimuli
- unmasked stimuli
- attentional interpretation
- response times
- location cueing
- visual perception
- Adult
- Attention
- Female
- Humans
- Male
- Models
- Psychological
- Perceptual Masking
- Psychometrics
- Reaction Time
- Task Performance and Analysis
- Time Perception
- Masking
- Reaction Time
- Response Latency
- Stimulus Parameters
- Visual Contrast
- Attention
- Cues
- Priming
- Temporal Frequency
- Temporal Order (Judgment)
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://kw.uni-paderborn.de/fileadmin/fakultaet/Institute/psychologie/Kognitive_Psychologie/Publikationen/ScharlauNeumann2003PsychResPLP.pdf
oa: '1'
page: 184 - 196
publication: Psychological Research
publication_identifier:
issn:
- 0340-0727
publication_status: published
status: public
title: 'Perceptual latency priming by masked and unmasked stimuli: Evidence for an
attentional interpretation.'
type: journal_article
user_id: '42165'
volume: 67
year: '2003'
...