[{"type":"journal_article","status":"public","_id":"59510","department":[{"_id":"163"}],"user_id":"94","article_number":"278","publication_identifier":{"issn":["2310-2861"]},"publication_status":"published","intvolume":"        11","citation":{"ama":"Killi N, Rumpke K, Kuckling D. Synthesis of Curcumin Derivatives via Knoevenagel Reaction Within a Continuously Driven Microfluidic Reactor Using Polymeric Networks Containing Piperidine as a Catalyst. <i>Gels</i>. 2025;11(4). doi:<a href=\"https://doi.org/10.3390/gels11040278\">10.3390/gels11040278</a>","ieee":"N. Killi, K. Rumpke, and D. Kuckling, “Synthesis of Curcumin Derivatives via Knoevenagel Reaction Within a Continuously Driven Microfluidic Reactor Using Polymeric Networks Containing Piperidine as a Catalyst,” <i>Gels</i>, vol. 11, no. 4, Art. no. 278, 2025, doi: <a href=\"https://doi.org/10.3390/gels11040278\">10.3390/gels11040278</a>.","chicago":"Killi, Naresh, Katja Rumpke, and Dirk Kuckling. “Synthesis of Curcumin Derivatives via Knoevenagel Reaction Within a Continuously Driven Microfluidic Reactor Using Polymeric Networks Containing Piperidine as a Catalyst.” <i>Gels</i> 11, no. 4 (2025). <a href=\"https://doi.org/10.3390/gels11040278\">https://doi.org/10.3390/gels11040278</a>.","apa":"Killi, N., Rumpke, K., &#38; Kuckling, D. (2025). Synthesis of Curcumin Derivatives via Knoevenagel Reaction Within a Continuously Driven Microfluidic Reactor Using Polymeric Networks Containing Piperidine as a Catalyst. <i>Gels</i>, <i>11</i>(4), Article 278. <a href=\"https://doi.org/10.3390/gels11040278\">https://doi.org/10.3390/gels11040278</a>","short":"N. Killi, K. Rumpke, D. Kuckling, Gels 11 (2025).","mla":"Killi, Naresh, et al. “Synthesis of Curcumin Derivatives via Knoevenagel Reaction Within a Continuously Driven Microfluidic Reactor Using Polymeric Networks Containing Piperidine as a Catalyst.” <i>Gels</i>, vol. 11, no. 4, 278, MDPI AG, 2025, doi:<a href=\"https://doi.org/10.3390/gels11040278\">10.3390/gels11040278</a>.","bibtex":"@article{Killi_Rumpke_Kuckling_2025, title={Synthesis of Curcumin Derivatives via Knoevenagel Reaction Within a Continuously Driven Microfluidic Reactor Using Polymeric Networks Containing Piperidine as a Catalyst}, volume={11}, DOI={<a href=\"https://doi.org/10.3390/gels11040278\">10.3390/gels11040278</a>}, number={4278}, journal={Gels}, publisher={MDPI AG}, author={Killi, Naresh and Rumpke, Katja and Kuckling, Dirk}, year={2025} }"},"date_updated":"2025-04-11T07:13:26Z","volume":11,"author":[{"last_name":"Killi","full_name":"Killi, Naresh","first_name":"Naresh"},{"first_name":"Katja","last_name":"Rumpke","full_name":"Rumpke, Katja"},{"first_name":"Dirk","full_name":"Kuckling, Dirk","id":"287","last_name":"Kuckling"}],"doi":"10.3390/gels11040278","main_file_link":[{"url":"https://www.mdpi.com/2310-2861/11/4/278"}],"publication":"Gels","abstract":[{"lang":"eng","text":"<jats:p>The use of organo-catalysis in continuous-flow reactor systems is gaining attention in medicinal chemistry due to its cost-effectiveness and reduced chemical waste. In this study, bioactive curcumin (CUM) derivatives were synthesized in a continuously operated microfluidic reactor (MFR), using piperidine-based polymeric networks as catalysts. Piperidine methacrylate and piperidine acrylate were synthesized and subsequently copolymerized with complementary monomers (MMA or DMAA) and crosslinkers (EGDMA or MBAM) via photopolymerization, yielding different polymeric networks. Initially, batch reactions were optimized for the organo-catalytic Knoevenagel condensation between CUM and 4-nitrobenzaldehyde, under various conditions, in the presence of polymer networks. Conversion was assessed using offline 1H NMR spectroscopy, revealing an increase in conversion with enhanced swelling properties of the polymer networks, which facilitated greater accessibility of catalytic sites. In continuous-flow MFR experiments, optimized polymer gel dots exhibited superior catalytic performance, achieving a conversion of up to 72%, compared to other compositions. This improvement was attributed to the enhanced swelling in the reaction mixture (DMSO/methanol, 7:3 v/v) at 40 °C over 72 h. Furthermore, the MFR system enabled the efficient synthesis of a series of CUM derivatives, demonstrating significantly higher conversion rates than traditional batch reactions. Notably, while batch reactions required 90% catalyst loading in the gel, the MFR system achieved a comparable or superior performance with only 50% catalyst, resulting in a higher turnover number. These findings underscore the advantages of continuous-flow organo-catalysis in enhancing catalytic efficiency and sustainability in organic synthesis.</jats:p>"}],"keyword":["flow chemistry","heterogeneous catalysis","sustainable synthesis","organo-catalysis","polymeric gel dots"],"language":[{"iso":"eng"}],"issue":"4","year":"2025","publisher":"MDPI AG","date_created":"2025-04-11T07:12:02Z","title":"Synthesis of Curcumin Derivatives via Knoevenagel Reaction Within a Continuously Driven Microfluidic Reactor Using Polymeric Networks Containing Piperidine as a Catalyst"},{"main_file_link":[{"open_access":"1","url":"https://www.sciencedirect.com/science/article/pii/S2666330925000536?via%3Dihub"}],"doi":"10.1016/j.jajp.2025.100332","author":[{"first_name":"Alex","full_name":"Jordan, Alex","id":"62451","orcid":"0009-0007-9546-6071","last_name":"Jordan"},{"last_name":"Hermelingmeier","id":"58649","full_name":"Hermelingmeier, Lucas","first_name":"Lucas"},{"first_name":"Julian","full_name":"Gilich, Julian","id":"44391","last_name":"Gilich"},{"id":"32056","full_name":"Meschut, Gerson","orcid":"0000-0002-2763-1246","last_name":"Meschut","first_name":"Gerson"},{"full_name":"De Santis, Marco Sebastian","id":"52239","last_name":"De Santis","first_name":"Marco Sebastian"},{"first_name":"Alexander","full_name":"Schlüter, Alexander","id":"103302","last_name":"Schlüter","orcid":"0000-0002-2569-1624"}],"volume":12,"oa":"1","date_updated":"2026-01-06T08:22:54Z","citation":{"mla":"Jordan, Alex, et al. “Comparison of the Economic Efficiency and Sustainability of Two Debonding Processes for Structurally Bonded Sills.” <i>Journal of Advanced Joining Processes</i>, vol. 12, 100332, Elsevier, 2025, doi:<a href=\"https://doi.org/10.1016/j.jajp.2025.100332\">10.1016/j.jajp.2025.100332</a>.","short":"A. Jordan, L. Hermelingmeier, J. Gilich, G. Meschut, M.S. De Santis, A. Schlüter, Journal of Advanced Joining Processes 12 (2025).","bibtex":"@article{Jordan_Hermelingmeier_Gilich_Meschut_De Santis_Schlüter_2025, title={Comparison of the economic efficiency and sustainability of two debonding processes for structurally bonded sills}, volume={12}, DOI={<a href=\"https://doi.org/10.1016/j.jajp.2025.100332\">10.1016/j.jajp.2025.100332</a>}, number={100332}, journal={Journal of Advanced Joining Processes}, publisher={Elsevier}, author={Jordan, Alex and Hermelingmeier, Lucas and Gilich, Julian and Meschut, Gerson and De Santis, Marco Sebastian and Schlüter, Alexander}, year={2025} }","apa":"Jordan, A., Hermelingmeier, L., Gilich, J., Meschut, G., De Santis, M. S., &#38; Schlüter, A. (2025). Comparison of the economic efficiency and sustainability of two debonding processes for structurally bonded sills. <i>Journal of Advanced Joining Processes</i>, <i>12</i>, Article 100332. <a href=\"https://doi.org/10.1016/j.jajp.2025.100332\">https://doi.org/10.1016/j.jajp.2025.100332</a>","chicago":"Jordan, Alex, Lucas Hermelingmeier, Julian Gilich, Gerson Meschut, Marco Sebastian De Santis, and Alexander Schlüter. “Comparison of the Economic Efficiency and Sustainability of Two Debonding Processes for Structurally Bonded Sills.” <i>Journal of Advanced Joining Processes</i> 12 (2025). <a href=\"https://doi.org/10.1016/j.jajp.2025.100332\">https://doi.org/10.1016/j.jajp.2025.100332</a>.","ieee":"A. Jordan, L. Hermelingmeier, J. Gilich, G. Meschut, M. S. De Santis, and A. Schlüter, “Comparison of the economic efficiency and sustainability of two debonding processes for structurally bonded sills,” <i>Journal of Advanced Joining Processes</i>, vol. 12, Art. no. 100332, 2025, doi: <a href=\"https://doi.org/10.1016/j.jajp.2025.100332\">10.1016/j.jajp.2025.100332</a>.","ama":"Jordan A, Hermelingmeier L, Gilich J, Meschut G, De Santis MS, Schlüter A. Comparison of the economic efficiency and sustainability of two debonding processes for structurally bonded sills. <i>Journal of Advanced Joining Processes</i>. 2025;12. doi:<a href=\"https://doi.org/10.1016/j.jajp.2025.100332\">10.1016/j.jajp.2025.100332</a>"},"intvolume":"        12","publication_status":"published","publication_identifier":{"issn":["2666-3309"]},"article_number":"100332","article_type":"original","user_id":"103302","department":[{"_id":"157"},{"_id":"876"},{"_id":"321"},{"_id":"9"}],"_id":"60837","status":"public","type":"journal_article","title":"Comparison of the economic efficiency and sustainability of two debonding processes for structurally bonded sills","date_created":"2025-07-30T11:04:28Z","publisher":"Elsevier","year":"2025","quality_controlled":"1","language":[{"iso":"eng"}],"keyword":["Sustainable debonding","Structural adhesives","Sustainable joining technologies","Life Cycle Assessment (LCA)","Automotive repair process","Economically efficient debonding"],"abstract":[{"text":"In light of growing demands for resource efficiency and sustainability in vehicle engineering, the environmentally compatible separation of structural adhesive joints is gaining increasing relevance. This study presents a comparative analysis of two physically based debonding methods: the established hot-air process and a cryogenic cold process based on liquid nitrogen (LN2). The primary objective is to assess the ecological impact and process-related sustainability of both approaches.\r\nExperimental investigations were conducted on a component-representative triple-sheet structure that simulates common automotive flange joints. Thermal input was applied either by convective heating using a hot air gun or by direct cooling through a contact-based LN2 tool. The resulting temperature profiles were recorded using spatially distributed thermocouples. Subsequently, the outer panel was selectively debonded to replicate a repair scenario, and the mechanical integrity of the remaining adhesive joint was evaluated through Mode I testing of L-shaped specimens. Process data served as input for an Life Cycle Assessment (LCA) according to DIN EN ISO 14040.\r\nThe cryogenic method achieved a 40% reduction in carbon footprint compared to the hot-air process (0.337 kg vs. 0.559 kg CO2-equivalents), primarily due to its shorter process time and more efficient heat transfer. While the hot-air method’s impact is mainly driven by electrical energy use, that of the cold method stems from cryogenic media consumption. Notwithstanding certain disadvantages in specific impact categories, the LN2-based process exhibits a superior overall ecological performance and signifies a promising solution for repair- and recycling-oriented adhesive separation in structural vehicle applications.","lang":"eng"}],"publication":"Journal of Advanced Joining Processes"},{"publisher":"MDPI","date_created":"2024-09-03T13:49:42Z","title":"Gas Sensing with Nanoporous In2O3 under Cyclic Optical Activation: Machine Learning-Aided Classification of H2 and H2O","quality_controlled":"1","issue":"9","year":"2024","ddc":["540"],"keyword":["resistive gas sensor","chemiresistor","semiconductor","metal oxide","In2O3","mesoporous","hydrogen","humidtiy","machine learning","sustainable"],"language":[{"iso":"eng"}],"publication":"Chemosensors","abstract":[{"lang":"eng","text":"Clean hydrogen is a key aspect of carbon neutrality, necessitating robust methods for monitoring hydrogen concentration in critical infrastructures like pipelines or power plants. While semiconducting metal oxides such as In2O3 can monitor gas concentrations down to the ppm range, they often exhibit cross-sensitivity to other gases like H2O. In this study, we investigated whether cyclic optical illumination of a gas-sensitive In2O3 layer creates identifiable changes in a gas sensor´s electronic resistance that can be linked to H2 and H2O concentrations via machine learning. We exposed nanostructured In2O3 with a large surface area of 95 m2 g-1 to H2 concentrations (0-800 ppm) and relative humidity (0-70%) under cyclic activation utilizing blue light. The sensors were tested for 20 classes of gas combinations. A support vector machine achieved classification rates up to 92.0%, with reliable reproducibility (88.2 ± 2.7%) across five individual sensors using 10-fold cross-validation. Our findings suggest that cyclic optical activation can be used as a tool to classify H2 and H2O concentrations."}],"file":[{"file_size":3275869,"access_level":"closed","file_name":"chemosensors-12-00178.pdf","file_id":"56000","date_updated":"2024-09-03T13:58:18Z","creator":"cweinber","date_created":"2024-09-03T13:58:18Z","success":1,"relation":"main_file","content_type":"application/pdf"}],"license":"https://creativecommons.org/licenses/by/4.0/","oa":"1","date_updated":"2025-11-26T12:14:21Z","author":[{"first_name":"Dominik ","full_name":"Baier, Dominik ","last_name":"Baier"},{"last_name":"Krüger","full_name":"Krüger, Alexander ","first_name":"Alexander "},{"last_name":"Wagner","full_name":"Wagner, Thorsten ","first_name":"Thorsten "},{"id":"23547","full_name":"Tiemann, Michael","orcid":"0000-0003-1711-2722","last_name":"Tiemann","first_name":"Michael"},{"last_name":"Weinberger","full_name":"Weinberger, Christian","id":"11848","first_name":"Christian"}],"volume":12,"main_file_link":[{"open_access":"1","url":"https://www.mdpi.com/2227-9040/12/9/178"}],"doi":"10.3390/chemosensors12090178","publication_status":"published","has_accepted_license":"1","publication_identifier":{"issn":["2227-9040"]},"citation":{"ieee":"D. Baier, A. Krüger, T. Wagner, M. Tiemann, and C. Weinberger, “Gas Sensing with Nanoporous In2O3 under Cyclic Optical Activation: Machine Learning-Aided Classification of H2 and H2O,” <i>Chemosensors</i>, vol. 12, no. 9, p. 178, 2024, doi: <a href=\"https://doi.org/10.3390/chemosensors12090178\">10.3390/chemosensors12090178</a>.","chicago":"Baier, Dominik , Alexander  Krüger, Thorsten  Wagner, Michael Tiemann, and Christian Weinberger. “Gas Sensing with Nanoporous In2O3 under Cyclic Optical Activation: Machine Learning-Aided Classification of H2 and H2O.” <i>Chemosensors</i> 12, no. 9 (2024): 178. <a href=\"https://doi.org/10.3390/chemosensors12090178\">https://doi.org/10.3390/chemosensors12090178</a>.","ama":"Baier D, Krüger A, Wagner T, Tiemann M, Weinberger C. Gas Sensing with Nanoporous In2O3 under Cyclic Optical Activation: Machine Learning-Aided Classification of H2 and H2O. <i>Chemosensors</i>. 2024;12(9):178. doi:<a href=\"https://doi.org/10.3390/chemosensors12090178\">10.3390/chemosensors12090178</a>","mla":"Baier, Dominik, et al. “Gas Sensing with Nanoporous In2O3 under Cyclic Optical Activation: Machine Learning-Aided Classification of H2 and H2O.” <i>Chemosensors</i>, vol. 12, no. 9, MDPI, 2024, p. 178, doi:<a href=\"https://doi.org/10.3390/chemosensors12090178\">10.3390/chemosensors12090178</a>.","bibtex":"@article{Baier_Krüger_Wagner_Tiemann_Weinberger_2024, title={Gas Sensing with Nanoporous In2O3 under Cyclic Optical Activation: Machine Learning-Aided Classification of H2 and H2O}, volume={12}, DOI={<a href=\"https://doi.org/10.3390/chemosensors12090178\">10.3390/chemosensors12090178</a>}, number={9}, journal={Chemosensors}, publisher={MDPI}, author={Baier, Dominik  and Krüger, Alexander  and Wagner, Thorsten  and Tiemann, Michael and Weinberger, Christian}, year={2024}, pages={178} }","short":"D. Baier, A. Krüger, T. Wagner, M. Tiemann, C. Weinberger, Chemosensors 12 (2024) 178.","apa":"Baier, D., Krüger, A., Wagner, T., Tiemann, M., &#38; Weinberger, C. (2024). Gas Sensing with Nanoporous In2O3 under Cyclic Optical Activation: Machine Learning-Aided Classification of H2 and H2O. <i>Chemosensors</i>, <i>12</i>(9), 178. <a href=\"https://doi.org/10.3390/chemosensors12090178\">https://doi.org/10.3390/chemosensors12090178</a>"},"page":"178","intvolume":"        12","_id":"55999","user_id":"11848","department":[{"_id":"2"},{"_id":"307"}],"article_type":"original","file_date_updated":"2024-09-03T13:58:18Z","type":"journal_article","status":"public"},{"date_created":"2023-04-13T09:11:33Z","author":[{"first_name":"Moritz","id":"44763","full_name":"Ostermann, Moritz","last_name":"Ostermann","orcid":"https://orcid.org/0000-0003-1146-0443"},{"first_name":"Julian","full_name":"Grenz, Julian","last_name":"Grenz"},{"full_name":"Triebus, Marcel","id":"66036","last_name":"Triebus","first_name":"Marcel"},{"full_name":"Cerdas, Felipe","last_name":"Cerdas","first_name":"Felipe"},{"first_name":"Thorsten","full_name":"Marten, Thorsten","id":"338","last_name":"Marten"},{"full_name":"Tröster, Thomas","id":"553","last_name":"Tröster","first_name":"Thomas"},{"last_name":"Herrmann","full_name":"Herrmann, Christoph","first_name":"Christoph"}],"volume":16,"date_updated":"2023-04-13T09:19:56Z","oa":"1","publisher":"MDPI AG","main_file_link":[{"open_access":"1","url":"https://www.mdpi.com/1996-1073/16/8/3371"}],"doi":"10.3390/en16083371","title":"Integrating Prospective Scenarios in Life Cycle Engineering: Case Study of Lightweight Structures","issue":"8","publication_status":"published","publication_identifier":{"issn":["1996-1073"]},"quality_controlled":"1","citation":{"apa":"Ostermann, M., Grenz, J., Triebus, M., Cerdas, F., Marten, T., Tröster, T., &#38; Herrmann, C. (2023). Integrating Prospective Scenarios in Life Cycle Engineering: Case Study of Lightweight Structures. <i>Energies</i>, <i>16</i>(8), Article 3371. <a href=\"https://doi.org/10.3390/en16083371\">https://doi.org/10.3390/en16083371</a>","bibtex":"@article{Ostermann_Grenz_Triebus_Cerdas_Marten_Tröster_Herrmann_2023, title={Integrating Prospective Scenarios in Life Cycle Engineering: Case Study of Lightweight Structures}, volume={16}, DOI={<a href=\"https://doi.org/10.3390/en16083371\">10.3390/en16083371</a>}, number={83371}, journal={Energies}, publisher={MDPI AG}, author={Ostermann, Moritz and Grenz, Julian and Triebus, Marcel and Cerdas, Felipe and Marten, Thorsten and Tröster, Thomas and Herrmann, Christoph}, year={2023} }","mla":"Ostermann, Moritz, et al. “Integrating Prospective Scenarios in Life Cycle Engineering: Case Study of Lightweight Structures.” <i>Energies</i>, vol. 16, no. 8, 3371, MDPI AG, 2023, doi:<a href=\"https://doi.org/10.3390/en16083371\">10.3390/en16083371</a>.","short":"M. Ostermann, J. Grenz, M. Triebus, F. Cerdas, T. Marten, T. Tröster, C. Herrmann, Energies 16 (2023).","ama":"Ostermann M, Grenz J, Triebus M, et al. Integrating Prospective Scenarios in Life Cycle Engineering: Case Study of Lightweight Structures. <i>Energies</i>. 2023;16(8). doi:<a href=\"https://doi.org/10.3390/en16083371\">10.3390/en16083371</a>","chicago":"Ostermann, Moritz, Julian Grenz, Marcel Triebus, Felipe Cerdas, Thorsten Marten, Thomas Tröster, and Christoph Herrmann. “Integrating Prospective Scenarios in Life Cycle Engineering: Case Study of Lightweight Structures.” <i>Energies</i> 16, no. 8 (2023). <a href=\"https://doi.org/10.3390/en16083371\">https://doi.org/10.3390/en16083371</a>.","ieee":"M. Ostermann <i>et al.</i>, “Integrating Prospective Scenarios in Life Cycle Engineering: Case Study of Lightweight Structures,” <i>Energies</i>, vol. 16, no. 8, Art. no. 3371, 2023, doi: <a href=\"https://doi.org/10.3390/en16083371\">10.3390/en16083371</a>."},"intvolume":"        16","year":"2023","user_id":"44763","department":[{"_id":"9"},{"_id":"321"},{"_id":"149"}],"_id":"43464","language":[{"iso":"eng"}],"article_number":"3371","keyword":["Life Cycle Engineering","Life Cycle Assessment","Lightweight Design","Prospective LCA","Future-oriented LCA","Energy System","Material production","Sustainable production"],"type":"journal_article","publication":"Energies","status":"public","abstract":[{"text":"<jats:p>Lightweight design is a common approach to reduce energy demand in the use stage of vehicles. The production of lightweight materials is usually associated with an increase in energy demand, so the environmental impacts of lightweight structures need to be assessed holistically using a life cycle assessment. To estimate the life cycle environmental impacts of a product in its developmental stage, for example, by life cycle engineering, future changes in relevant influencing factors must be considered. Prospective life cycle assessment provides methods for integrating future scenarios into life cycle assessment studies. However, approaches for integrating prospective life cycle assessment into product development are limited. The objective of this work is to provide the methodological foundation for integrating future scenarios of relevant influencing factors in the development of lightweight structures. The applicability of the novel methodology is demonstrated by a case study of a structural component in a steel, aluminium, and hybrid design. The results show that appropriate decarbonisation measures can reduce the life cycle greenhouse gas emissions by up to 95 percent until 2050. We also found that shifts in the environmentally optimal design are possible in future scenarios. Therefore, the methodology and data provided contribute to improved decision-making in product development.</jats:p>","lang":"eng"}]}]