---
_id: '59509'
abstract:
- lang: eng
  text: <jats:title>Abstract</jats:title><jats:p>A strategy for multifunctional biosurfaces
    exploiting multiblock copolymers and the antipolyelectrolyte effect is reported.
    Combining a polyzwitterionic/antifouling and a polycationic/antibacterial block
    with a central anchoring block for attachment to titanium oxide surfaces affords
    surface coatings that exhibit antifouling properties against proteins and allow
    for surface regeneration by clearing adhering proteins by employing a salt washing
    step. The surfaces also kill bacteria by contact killing, which is aided by a
    nonfouling block. The synthesis of block copolymers of 4‐vinyl pyridine (VP),
    dimethyl 4‐vinylbenzyl phosphonate (DMVBP), and 4‐vinylbenzyltrimethyl ammonium
    chloride (TMA) is achieved on the multigram scale via RAFT polymerization with
    good end group retention and narrow dispersities. By polymer analogous reactions,
    poly(4‐vinyl pyridinium propane sulfonate‐<jats:italic>block</jats:italic>‐4‐vinylbenzyl
    phosphonic acid‐<jats:italic>block</jats:italic>‐4‐vinylbenzyl trimethylammonium
    chloride) (P(VSP<jats:sub>64</jats:sub>‐<jats:italic>b</jats:italic>‐PA<jats:sub>14</jats:sub>‐<jats:italic>b</jats:italic>‐TMA<jats:sub>64</jats:sub>))
    is obtained. The antifouling properties against the model protein pepsin and the
    salt‐induced surface regeneration are shown in surface plasmon resonance (SPR)
    experiments, while independently the antibacterial and antifouling properties
    of coated titanium substrates are successfully tested in preliminary microbiological
    assays against <jats:italic>Staphylococcus aureus</jats:italic> (<jats:italic>S.
    aureus</jats:italic>) and <jats:italic>Escherichia coli</jats:italic> (<jats:italic>E.
    coli</jats:italic>). This strategy may contribute to the development of long‐term
    effective antibacterial implant surface coatings to suppress biomedical device‐associated
    infections.</jats:p>
author:
- first_name: Rafael
  full_name: Methling, Rafael
  last_name: Methling
- first_name: Michael
  full_name: Greiter, Michael
  last_name: Greiter
- first_name: Jiwar
  full_name: Al‐Zawity, Jiwar
  last_name: Al‐Zawity
- first_name: Mareike
  full_name: Müller, Mareike
  last_name: Müller
- first_name: Holger
  full_name: Schönherr, Holger
  last_name: Schönherr
- first_name: Dirk
  full_name: Kuckling, Dirk
  id: '287'
  last_name: Kuckling
citation:
  ama: Methling R, Greiter M, Al‐Zawity J, Müller M, Schönherr H, Kuckling D. Salt‐Responsive
    Switchable Block Copolymer Brushes with Antibacterial and Antifouling Properties.
    <i>Macromolecular Bioscience</i>. 2024;25(1). doi:<a href="https://doi.org/10.1002/mabi.202400261">10.1002/mabi.202400261</a>
  apa: Methling, R., Greiter, M., Al‐Zawity, J., Müller, M., Schönherr, H., &#38;
    Kuckling, D. (2024). Salt‐Responsive Switchable Block Copolymer Brushes with Antibacterial
    and Antifouling Properties. <i>Macromolecular Bioscience</i>, <i>25</i>(1). <a
    href="https://doi.org/10.1002/mabi.202400261">https://doi.org/10.1002/mabi.202400261</a>
  bibtex: '@article{Methling_Greiter_Al‐Zawity_Müller_Schönherr_Kuckling_2024, title={Salt‐Responsive
    Switchable Block Copolymer Brushes with Antibacterial and Antifouling Properties},
    volume={25}, DOI={<a href="https://doi.org/10.1002/mabi.202400261">10.1002/mabi.202400261</a>},
    number={1}, journal={Macromolecular Bioscience}, publisher={Wiley}, author={Methling,
    Rafael and Greiter, Michael and Al‐Zawity, Jiwar and Müller, Mareike and Schönherr,
    Holger and Kuckling, Dirk}, year={2024} }'
  chicago: Methling, Rafael, Michael Greiter, Jiwar Al‐Zawity, Mareike Müller, Holger
    Schönherr, and Dirk Kuckling. “Salt‐Responsive Switchable Block Copolymer Brushes
    with Antibacterial and Antifouling Properties.” <i>Macromolecular Bioscience</i>
    25, no. 1 (2024). <a href="https://doi.org/10.1002/mabi.202400261">https://doi.org/10.1002/mabi.202400261</a>.
  ieee: 'R. Methling, M. Greiter, J. Al‐Zawity, M. Müller, H. Schönherr, and D. Kuckling,
    “Salt‐Responsive Switchable Block Copolymer Brushes with Antibacterial and Antifouling
    Properties,” <i>Macromolecular Bioscience</i>, vol. 25, no. 1, 2024, doi: <a href="https://doi.org/10.1002/mabi.202400261">10.1002/mabi.202400261</a>.'
  mla: Methling, Rafael, et al. “Salt‐Responsive Switchable Block Copolymer Brushes
    with Antibacterial and Antifouling Properties.” <i>Macromolecular Bioscience</i>,
    vol. 25, no. 1, Wiley, 2024, doi:<a href="https://doi.org/10.1002/mabi.202400261">10.1002/mabi.202400261</a>.
  short: R. Methling, M. Greiter, J. Al‐Zawity, M. Müller, H. Schönherr, D. Kuckling,
    Macromolecular Bioscience 25 (2024).
date_created: 2025-04-11T07:07:31Z
date_updated: 2025-04-11T07:09:03Z
department:
- _id: '163'
doi: 10.1002/mabi.202400261
intvolume: '        25'
issue: '1'
keyword:
- antibacterial coatings
- antipolyelectrolyte effect
- salt switchable polymers
- zwitterionic brushes
language:
- iso: eng
main_file_link:
- url: https://onlinelibrary.wiley.com/doi/10.1002/mabi.202400261
publication: Macromolecular Bioscience
publication_identifier:
  issn:
  - 1616-5187
  - 1616-5195
publication_status: published
publisher: Wiley
status: public
title: Salt‐Responsive Switchable Block Copolymer Brushes with Antibacterial and Antifouling
  Properties
type: journal_article
user_id: '94'
volume: 25
year: '2024'
...