[{"language":[{"iso":"eng"}],"keyword":["Chemistry (miscellaneous)","Analytical Chemistry","Organic Chemistry","Physical and Theoretical Chemistry","Molecular Medicine","Drug Discovery","Pharmaceutical Science"],"abstract":[{"text":"<jats:p>This article presents the potential-dependent adsorption of two proteins, bovine serum albumin (BSA) and lysozyme (LYZ), on Ti6Al4V alloy at pH 7.4 and 37 °C. The adsorption process was studied on an electropolished alloy under cathodic and anodic overpotentials, compared to the open circuit potential (OCP). To analyze the adsorption process, various complementary interface analytical techniques were employed, including PM-IRRAS (polarization-modulation infrared reflection-absorption spectroscopy), AFM (atomic force microscopy), XPS (X-ray photoelectron spectroscopy), and E-QCM (electrochemical quartz crystal microbalance) measurements. The polarization experiments were conducted within a potential range where charging of the electric double layer dominates, and Faradaic currents can be disregarded. The findings highlight the significant influence of the interfacial charge distribution on the adsorption of BSA and LYZ onto the alloy surface. Furthermore, electrochemical analysis of the protein layers formed under applied overpotentials demonstrated improved corrosion protection properties. These studies provide valuable insights into protein adsorption on titanium alloys under physiological conditions, characterized by varying potentials of the passive alloy.</jats:p>","lang":"eng"}],"publication":"Molecules","title":"Electrode Potential-Dependent Studies of Protein Adsorption on Ti6Al4V Alloy","date_created":"2023-07-03T08:06:28Z","publisher":"MDPI AG","year":"2023","issue":"13","user_id":"48864","department":[{"_id":"302"}],"_id":"45828","status":"public","type":"journal_article","doi":"10.3390/molecules28135109","author":[{"first_name":"Belma","last_name":"Duderija","full_name":"Duderija, Belma","id":"54863"},{"first_name":"Alejandro","full_name":"González-Orive, Alejandro","last_name":"González-Orive"},{"full_name":"Ebbert, Christoph","id":"7266","last_name":"Ebbert","first_name":"Christoph"},{"last_name":"Neßlinger","full_name":"Neßlinger, Vanessa","first_name":"Vanessa"},{"first_name":"Adrian","full_name":"Keller, Adrian","id":"48864","orcid":"0000-0001-7139-3110","last_name":"Keller"},{"id":"194","full_name":"Grundmeier, Guido","last_name":"Grundmeier","first_name":"Guido"}],"volume":28,"date_updated":"2023-07-03T08:07:55Z","citation":{"ieee":"B. Duderija, A. González-Orive, C. Ebbert, V. Neßlinger, A. Keller, and G. Grundmeier, “Electrode Potential-Dependent Studies of Protein Adsorption on Ti6Al4V Alloy,” <i>Molecules</i>, vol. 28, no. 13, p. 5109, 2023, doi: <a href=\"https://doi.org/10.3390/molecules28135109\">10.3390/molecules28135109</a>.","chicago":"Duderija, Belma, Alejandro González-Orive, Christoph Ebbert, Vanessa Neßlinger, Adrian Keller, and Guido Grundmeier. “Electrode Potential-Dependent Studies of Protein Adsorption on Ti6Al4V Alloy.” <i>Molecules</i> 28, no. 13 (2023): 5109. <a href=\"https://doi.org/10.3390/molecules28135109\">https://doi.org/10.3390/molecules28135109</a>.","ama":"Duderija B, González-Orive A, Ebbert C, Neßlinger V, Keller A, Grundmeier G. Electrode Potential-Dependent Studies of Protein Adsorption on Ti6Al4V Alloy. <i>Molecules</i>. 2023;28(13):5109. doi:<a href=\"https://doi.org/10.3390/molecules28135109\">10.3390/molecules28135109</a>","apa":"Duderija, B., González-Orive, A., Ebbert, C., Neßlinger, V., Keller, A., &#38; Grundmeier, G. (2023). Electrode Potential-Dependent Studies of Protein Adsorption on Ti6Al4V Alloy. <i>Molecules</i>, <i>28</i>(13), 5109. <a href=\"https://doi.org/10.3390/molecules28135109\">https://doi.org/10.3390/molecules28135109</a>","bibtex":"@article{Duderija_González-Orive_Ebbert_Neßlinger_Keller_Grundmeier_2023, title={Electrode Potential-Dependent Studies of Protein Adsorption on Ti6Al4V Alloy}, volume={28}, DOI={<a href=\"https://doi.org/10.3390/molecules28135109\">10.3390/molecules28135109</a>}, number={13}, journal={Molecules}, publisher={MDPI AG}, author={Duderija, Belma and González-Orive, Alejandro and Ebbert, Christoph and Neßlinger, Vanessa and Keller, Adrian and Grundmeier, Guido}, year={2023}, pages={5109} }","short":"B. Duderija, A. González-Orive, C. Ebbert, V. Neßlinger, A. Keller, G. Grundmeier, Molecules 28 (2023) 5109.","mla":"Duderija, Belma, et al. “Electrode Potential-Dependent Studies of Protein Adsorption on Ti6Al4V Alloy.” <i>Molecules</i>, vol. 28, no. 13, MDPI AG, 2023, p. 5109, doi:<a href=\"https://doi.org/10.3390/molecules28135109\">10.3390/molecules28135109</a>."},"page":"5109","intvolume":"        28","publication_status":"published","publication_identifier":{"issn":["1420-3049"]}},{"publication_identifier":{"issn":["2470-1343","2470-1343"]},"publication_status":"published","page":"2649-2660","intvolume":"         4","citation":{"chicago":"Hajiraissi, Roozbeh, Marcel Hanke, Alejandro Gonzalez Orive, Belma Duderija, Ulrike Hofmann, Yixin Zhang, Guido Grundmeier, and Adrian Keller. “Effect of Terminal Modifications on the Adsorption and Assembly of HIAPP(20–29).” <i>ACS Omega</i> 4 (2019): 2649–60. <a href=\"https://doi.org/10.1021/acsomega.8b03028\">https://doi.org/10.1021/acsomega.8b03028</a>.","ieee":"R. Hajiraissi <i>et al.</i>, “Effect of Terminal Modifications on the Adsorption and Assembly of hIAPP(20–29),” <i>ACS Omega</i>, vol. 4, pp. 2649–2660, 2019.","ama":"Hajiraissi R, Hanke M, Gonzalez Orive A, et al. Effect of Terminal Modifications on the Adsorption and Assembly of hIAPP(20–29). <i>ACS Omega</i>. 2019;4:2649-2660. doi:<a href=\"https://doi.org/10.1021/acsomega.8b03028\">10.1021/acsomega.8b03028</a>","apa":"Hajiraissi, R., Hanke, M., Gonzalez Orive, A., Duderija, B., Hofmann, U., Zhang, Y., … Keller, A. (2019). Effect of Terminal Modifications on the Adsorption and Assembly of hIAPP(20–29). <i>ACS Omega</i>, <i>4</i>, 2649–2660. <a href=\"https://doi.org/10.1021/acsomega.8b03028\">https://doi.org/10.1021/acsomega.8b03028</a>","mla":"Hajiraissi, Roozbeh, et al. “Effect of Terminal Modifications on the Adsorption and Assembly of HIAPP(20–29).” <i>ACS Omega</i>, vol. 4, 2019, pp. 2649–60, doi:<a href=\"https://doi.org/10.1021/acsomega.8b03028\">10.1021/acsomega.8b03028</a>.","short":"R. Hajiraissi, M. Hanke, A. Gonzalez Orive, B. Duderija, U. Hofmann, Y. Zhang, G. Grundmeier, A. Keller, ACS Omega 4 (2019) 2649–2660.","bibtex":"@article{Hajiraissi_Hanke_Gonzalez Orive_Duderija_Hofmann_Zhang_Grundmeier_Keller_2019, title={Effect of Terminal Modifications on the Adsorption and Assembly of hIAPP(20–29)}, volume={4}, DOI={<a href=\"https://doi.org/10.1021/acsomega.8b03028\">10.1021/acsomega.8b03028</a>}, journal={ACS Omega}, author={Hajiraissi, Roozbeh and Hanke, Marcel and Gonzalez Orive, Alejandro and Duderija, Belma and Hofmann, Ulrike and Zhang, Yixin and Grundmeier, Guido and Keller, Adrian}, year={2019}, pages={2649–2660} }"},"year":"2019","volume":4,"author":[{"first_name":"Roozbeh","full_name":"Hajiraissi, Roozbeh","last_name":"Hajiraissi"},{"first_name":"Marcel","full_name":"Hanke, Marcel","last_name":"Hanke"},{"full_name":"Gonzalez Orive, Alejandro","last_name":"Gonzalez Orive","first_name":"Alejandro"},{"first_name":"Belma","last_name":"Duderija","full_name":"Duderija, Belma","id":"54863"},{"first_name":"Ulrike","full_name":"Hofmann, Ulrike","last_name":"Hofmann"},{"last_name":"Zhang","full_name":"Zhang, Yixin","first_name":"Yixin"},{"first_name":"Guido","last_name":"Grundmeier","full_name":"Grundmeier, Guido","id":"194"},{"first_name":"Adrian","id":"48864","full_name":"Keller, Adrian","last_name":"Keller","orcid":"0000-0001-7139-3110"}],"date_created":"2021-07-08T12:16:52Z","date_updated":"2022-01-06T06:55:38Z","doi":"10.1021/acsomega.8b03028","title":"Effect of Terminal Modifications on the Adsorption and Assembly of hIAPP(20–29)","publication":"ACS Omega","type":"journal_article","status":"public","department":[{"_id":"302"}],"user_id":"48864","_id":"22657","language":[{"iso":"eng"}]},{"department":[{"_id":"302"}],"user_id":"54863","_id":"22541","language":[{"iso":"eng"}],"publication":"Applied Surface Science","type":"journal_article","status":"public","abstract":[{"lang":"eng","text":"Monodisperse micron-sized silica particle monolayers deposited onto plasma-grown SiOx-ultra-thin films have been used as reference systems to investigate wetting, water adsorption and capillary bridge formation as a function of silica surface functionalization. 1H,1H, 2H,2H perfluorooctyltriethoxysil (FOTS) monolayers, have been deposited on the respective surfaces by means of chemical vapor deposition resulting in macroscopically low energy surfaces. X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared (FTIR) reflection absorption spectroscopy confirmed the monolayer formation. Water adsorption isotherms were studied by a combination of in-situ FTIR reflection spectroscopy and quartz crystal microbalance (QCM) while macroscopic wetting was analysed by contact angle measurements. The comparative data evaluation indicates that the macroscopic wetting behaviour was changed as expected, however, that water nanodroplets formed both at intrinsic defects of the FOTS monolayer and at the FOTS/SiOx interface. Capillary bridges of liquid water are dominantly formed in the confined particle contact areas and between surface asperities on the particles. The comparison of wetting, adsorption and capillary bridge formation shows that the hydrophobization of porous materials by organosilane monolayers leads to the formation of morphology dependent nanoscopic defects that act as sites for preferential capillary bridge formation."}],"date_created":"2021-07-07T08:40:38Z","author":[{"last_name":"Giner","full_name":"Giner, Ignacio","first_name":"Ignacio"},{"first_name":"Boray","full_name":"Torun, Boray","last_name":"Torun"},{"first_name":"Yan","last_name":"Han","full_name":"Han, Yan"},{"last_name":"Duderija","full_name":"Duderija, Belma","id":"54863","first_name":"Belma"},{"first_name":"Dennis","last_name":"Meinderink","full_name":"Meinderink, Dennis"},{"full_name":"Orive, Alejandro González","last_name":"Orive","first_name":"Alejandro González"},{"first_name":"Maria Teresa","last_name":"de los Arcos de Pedro","id":"54556","full_name":"de los Arcos de Pedro, Maria Teresa"},{"full_name":"Weinberger, Christian","last_name":"Weinberger","first_name":"Christian"},{"first_name":"Michael","orcid":"0000-0003-1711-2722","last_name":"Tiemann","full_name":"Tiemann, Michael","id":"23547"},{"full_name":"Schmid, Hans-Joachim","id":"464","orcid":"000-0001-8590-1921","last_name":"Schmid","first_name":"Hans-Joachim"},{"first_name":"Guido","id":"194","full_name":"Grundmeier, Guido","last_name":"Grundmeier"}],"date_updated":"2023-07-12T07:58:00Z","doi":"10.1016/j.apsusc.2018.12.221","title":"Water adsorption and capillary bridge formation on silica micro-particle layers modified with perfluorinated organosilane monolayers","publication_identifier":{"issn":["0169-4332"]},"publication_status":"published","page":"873-879","citation":{"chicago":"Giner, Ignacio, Boray Torun, Yan Han, Belma Duderija, Dennis Meinderink, Alejandro González Orive, Maria Teresa de los Arcos de Pedro, et al. “Water Adsorption and Capillary Bridge Formation on Silica Micro-Particle Layers Modified with Perfluorinated Organosilane Monolayers.” <i>Applied Surface Science</i>, 2019, 873–79. <a href=\"https://doi.org/10.1016/j.apsusc.2018.12.221\">https://doi.org/10.1016/j.apsusc.2018.12.221</a>.","ieee":"I. Giner <i>et al.</i>, “Water adsorption and capillary bridge formation on silica micro-particle layers modified with perfluorinated organosilane monolayers,” <i>Applied Surface Science</i>, pp. 873–879, 2019, doi: <a href=\"https://doi.org/10.1016/j.apsusc.2018.12.221\">10.1016/j.apsusc.2018.12.221</a>.","mla":"Giner, Ignacio, et al. “Water Adsorption and Capillary Bridge Formation on Silica Micro-Particle Layers Modified with Perfluorinated Organosilane Monolayers.” <i>Applied Surface Science</i>, 2019, pp. 873–79, doi:<a href=\"https://doi.org/10.1016/j.apsusc.2018.12.221\">10.1016/j.apsusc.2018.12.221</a>.","bibtex":"@article{Giner_Torun_Han_Duderija_Meinderink_Orive_de los Arcos de Pedro_Weinberger_Tiemann_Schmid_et al._2019, title={Water adsorption and capillary bridge formation on silica micro-particle layers modified with perfluorinated organosilane monolayers}, DOI={<a href=\"https://doi.org/10.1016/j.apsusc.2018.12.221\">10.1016/j.apsusc.2018.12.221</a>}, journal={Applied Surface Science}, author={Giner, Ignacio and Torun, Boray and Han, Yan and Duderija, Belma and Meinderink, Dennis and Orive, Alejandro González and de los Arcos de Pedro, Maria Teresa and Weinberger, Christian and Tiemann, Michael and Schmid, Hans-Joachim and et al.}, year={2019}, pages={873–879} }","short":"I. Giner, B. Torun, Y. Han, B. Duderija, D. Meinderink, A.G. Orive, M.T. de los Arcos de Pedro, C. Weinberger, M. Tiemann, H.-J. Schmid, G. Grundmeier, Applied Surface Science (2019) 873–879.","apa":"Giner, I., Torun, B., Han, Y., Duderija, B., Meinderink, D., Orive, A. G., de los Arcos de Pedro, M. T., Weinberger, C., Tiemann, M., Schmid, H.-J., &#38; Grundmeier, G. (2019). Water adsorption and capillary bridge formation on silica micro-particle layers modified with perfluorinated organosilane monolayers. <i>Applied Surface Science</i>, 873–879. <a href=\"https://doi.org/10.1016/j.apsusc.2018.12.221\">https://doi.org/10.1016/j.apsusc.2018.12.221</a>","ama":"Giner I, Torun B, Han Y, et al. Water adsorption and capillary bridge formation on silica micro-particle layers modified with perfluorinated organosilane monolayers. <i>Applied Surface Science</i>. Published online 2019:873-879. doi:<a href=\"https://doi.org/10.1016/j.apsusc.2018.12.221\">10.1016/j.apsusc.2018.12.221</a>"},"year":"2019"},{"page":"3517-3524","intvolume":"        34","citation":{"ama":"Hajiraissi R, Hanke M, Yang Y, et al. Adsorption and Fibrillization of Islet Amyloid Polypeptide at Self-Assembled Monolayers Studied by QCM-D, AFM, and PM-IRRAS. <i>Langmuir</i>. 2018;34:3517-3524. doi:<a href=\"https://doi.org/10.1021/acs.langmuir.7b03626\">10.1021/acs.langmuir.7b03626</a>","ieee":"R. Hajiraissi <i>et al.</i>, “Adsorption and Fibrillization of Islet Amyloid Polypeptide at Self-Assembled Monolayers Studied by QCM-D, AFM, and PM-IRRAS,” <i>Langmuir</i>, vol. 34, pp. 3517–3524, 2018.","chicago":"Hajiraissi, Roozbeh, Marcel Hanke, Yu Yang, Belma Duderija, Alejandro Gonzalez Orive, Guido Grundmeier, and Adrian Keller. “Adsorption and Fibrillization of Islet Amyloid Polypeptide at Self-Assembled Monolayers Studied by QCM-D, AFM, and PM-IRRAS.” <i>Langmuir</i> 34 (2018): 3517–24. <a href=\"https://doi.org/10.1021/acs.langmuir.7b03626\">https://doi.org/10.1021/acs.langmuir.7b03626</a>.","bibtex":"@article{Hajiraissi_Hanke_Yang_Duderija_Gonzalez Orive_Grundmeier_Keller_2018, title={Adsorption and Fibrillization of Islet Amyloid Polypeptide at Self-Assembled Monolayers Studied by QCM-D, AFM, and PM-IRRAS}, volume={34}, DOI={<a href=\"https://doi.org/10.1021/acs.langmuir.7b03626\">10.1021/acs.langmuir.7b03626</a>}, journal={Langmuir}, author={Hajiraissi, Roozbeh and Hanke, Marcel and Yang, Yu and Duderija, Belma and Gonzalez Orive, Alejandro and Grundmeier, Guido and Keller, Adrian}, year={2018}, pages={3517–3524} }","mla":"Hajiraissi, Roozbeh, et al. “Adsorption and Fibrillization of Islet Amyloid Polypeptide at Self-Assembled Monolayers Studied by QCM-D, AFM, and PM-IRRAS.” <i>Langmuir</i>, vol. 34, 2018, pp. 3517–24, doi:<a href=\"https://doi.org/10.1021/acs.langmuir.7b03626\">10.1021/acs.langmuir.7b03626</a>.","short":"R. Hajiraissi, M. Hanke, Y. Yang, B. Duderija, A. Gonzalez Orive, G. Grundmeier, A. Keller, Langmuir 34 (2018) 3517–3524.","apa":"Hajiraissi, R., Hanke, M., Yang, Y., Duderija, B., Gonzalez Orive, A., Grundmeier, G., &#38; Keller, A. (2018). Adsorption and Fibrillization of Islet Amyloid Polypeptide at Self-Assembled Monolayers Studied by QCM-D, AFM, and PM-IRRAS. <i>Langmuir</i>, <i>34</i>, 3517–3524. <a href=\"https://doi.org/10.1021/acs.langmuir.7b03626\">https://doi.org/10.1021/acs.langmuir.7b03626</a>"},"year":"2018","publication_identifier":{"issn":["0743-7463","1520-5827"]},"publication_status":"published","doi":"10.1021/acs.langmuir.7b03626","title":"Adsorption and Fibrillization of Islet Amyloid Polypeptide at Self-Assembled Monolayers Studied by QCM-D, AFM, and PM-IRRAS","volume":34,"author":[{"last_name":"Hajiraissi","full_name":"Hajiraissi, Roozbeh","first_name":"Roozbeh"},{"first_name":"Marcel","last_name":"Hanke","full_name":"Hanke, Marcel"},{"last_name":"Yang","full_name":"Yang, Yu","first_name":"Yu"},{"id":"54863","full_name":"Duderija, Belma","last_name":"Duderija","first_name":"Belma"},{"last_name":"Gonzalez Orive","full_name":"Gonzalez Orive, Alejandro","first_name":"Alejandro"},{"first_name":"Guido","last_name":"Grundmeier","full_name":"Grundmeier, Guido","id":"194"},{"last_name":"Keller","orcid":"0000-0001-7139-3110","id":"48864","full_name":"Keller, Adrian","first_name":"Adrian"}],"date_created":"2021-07-08T12:36:59Z","date_updated":"2022-01-06T06:55:38Z","status":"public","publication":"Langmuir","type":"journal_article","language":[{"iso":"eng"}],"department":[{"_id":"302"}],"user_id":"48864","_id":"22667"}]