@article{52713, abstract = {{ABSTRACT OBJECTIVE: The aim of this analysis was to investigate whether habitual intake of total dairy (TD) or different dairy types (liquid, solid, fermented, not-fermented, low-fat, high-fat, low-sugar and high-sugar dairy) during adolescence is associated with biomarkers of low-grade inflammation as well as risk factors of type 2 diabetes in young adulthood. DESIGN: Multivariable linear regression analyses were used to investigate prospective associations between estimated TD intake as well as intake of different types of dairy and a pro-inflammatory score, based on hsCRP, IL-6, IL-18, leptin and adiponectin, and insulin resistance assessed as HOMA2-IR in an open cohort study. SETTING: Dortmund, Germany PARTICIPANTS: Data from participants (n=375) of the DOrtmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study were included, for whom at least two 3-day weighed dietary records during adolescence (median age: 11 years) and one blood sample in young adulthood (>18 years) were available. RESULTS: There was no statistically significant association between TD intake or intake of any dairy type and the pro-inflammatory score (all p>0.05). TD intake as well as each dairy type intake and insulin resistance also showed no association (all p>0.05). CONCLUSIONS: The habitual intake of dairy or individual types of dairy during adolescence does not seem to have a major impact on low-grade systemic inflammation and insulin resistance in the long term. There was no indication regarding a restriction of dairy intake for healthy children and adolescents in terms of diabetes risk reduction. }}, author = {{Hohoff, E and Jankovic, N and Perrar, I and Schnermann, ME and Herder, C and Nöthlings, U and Libuda, Lars and Alexy, U}}, issn = {{1368-9800}}, journal = {{Public Health Nutrition}}, keywords = {{Public Health, Environmental and Occupational Health, Nutrition and Dietetics, Medicine (miscellaneous)}}, pages = {{1--26}}, publisher = {{Cambridge University Press (CUP)}}, title = {{{The association between dairy intake in adolescents with inflammation and risk markers of type 2 diabetes during young adulthood – results of the DONALD study}}}, doi = {{10.1017/s1368980024000624}}, year = {{2024}}, } @article{52712, author = {{Buyken, Anette and Libuda, Lars}}, journal = {{DGEwissen}}, title = {{{Ernährung und Alltagsbewältigung - Ein Spannungsfeld für Individuum, Haushalt und Gesellschaft}}}, year = {{2024}}, } @article{36505, abstract = {{Young adults with a later chronotype are vulnerable for a discrepancy in sleep rhythm between work- and free days, called social jet lag (SJL). This study analysed (i) chronotype/SJL association with visceral fat/skeletal muscle mass, (ii) the attribution to physical activity behaviour, and (iii) chronotype-specific changes in physical activity behaviour in young adults during the Covid-19 pandemic lockdown. Chronotype and SJL were derived from the Munich-Chrono-Type-Questionnaire in 320 German students (age 18–25 years) from September 2019 to January 2020, 156 of these participated in an online follow-up survey in June 2020. Body composition was assessed by bioimpedance analysis at baseline. Multivariable linear regression analyses were used to relate chronotype/SJL to body composition; the contribution of self-reported physical activity was tested by mediation analysis. At baseline, a later chronotype and a larger SJL were associated with a higher visceral fat mass (P<0.05), this relation was notably mediated by the attention to physical activity (P<0.05). Chronotype (P = 0.02) but not SJL (P = 0.87) was inversely associated with skeletal muscle mass. During the pandemic lockdown, chronotype hardly changed, but SJL was reduced. Timing and physical activity behaviour remained in most participants and changes were unrelated to chronotype (all P>0.07). A later chronotype/higher SJL may increase the risk of a higher visceral fat mass even in this relatively healthy sample, which may be partly due to their physical activity behaviour. Despite a reduction in SJL during the pandemic lockdown, later chronotypes did not change their physical activity behaviour more than earlier chronotypes.}}, author = {{Krueger, Betina and Stutz, Bianca and Jankovic, Nicole and Alexy, Ute and Kilanowski, Anna and Libuda, Lars and Buyken, Anette E.}}, issn = {{1932-6203}}, journal = {{PLOS ONE}}, keywords = {{Multidisciplinary}}, number = {{1}}, publisher = {{Public Library of Science (PLoS)}}, title = {{{The association of chronotype and social jet lag with body composition in German students: The role of physical activity behaviour and the impact of the pandemic lockdown}}}, doi = {{10.1371/journal.pone.0279620}}, volume = {{18}}, year = {{2023}}, } @article{41456, abstract = {{Abstract Background The German total diet study (TDS)—BfR MEAL Study—established its food list in 2016 based on food consumption data of children (0.5–<5 years) and adults (14–80 years). The list consists of 356 foods selected for analysis in order to ensure ≥90% coverage of the diet. Recently, new food consumption data for children (0.5–<6 and 6–<12 years) in Germany became available, which raised the opportunity to evaluate the applicability of the MEAL food list 2016 on new data. Objective We tested the hypotheses that the MEAL food list 2016 also covers ≥90% of the diet of the new collected food consumption data, and that the selection of foods from younger children and adults was sufficient to also cover the middle age group (6–<12 years). Strategies for updating the existing food list were assessed. Methods Three approaches evaluated the reusability and potential adjustment strategies of the existing food list. Approach 1 applied the existing food list to new food consumption data. Approach 2 allowed the extension of the existing food list to improve coverage of food consumption. Approach 3 set up a new food list based on the new data. Results The MEAL food list 2016 covered 94% of the overall diet of the new collected food consumption data. The diet of the middle age group was sufficiently covered with 91%. However, coverage on main food group or population subgroup level was <90% in some cases. Approach 3 most accurately identified relevant modifications to the existing food list. 94% of the MEAL food list 2016 could be re-used and 51 new foods were identified as potentially relevant. Significance The results suggest that a high investment in the coverage of a TDS food list will lower the effort and the resources to keep data updated in the long-term. Impact There is no established approach to update a TDS food list. This study provides comparative approaches to handle newly collected food consumption data for follow-on TDS activities. The results provide useful information for institutions planning or updating a TDS. Furthermore, new food consumption data for children in Germany recently became available and are here presented for the first time. }}, author = {{Kolbaum, Anna Elena and Ptok, Sebastian and Jung, Christian and Libuda, Lars and Lindtner, Oliver}}, issn = {{1559-0631}}, journal = {{Journal of Exposure Science & Environmental Epidemiology}}, keywords = {{Public Health, Environmental and Occupational Health, Pollution, Toxicology, Epidemiology}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Reusability of Germany´s total diet study food list upon availability of new food consumption data—comparison of three update strategies}}}, doi = {{10.1038/s41370-023-00522-4}}, year = {{2023}}, } @article{45813, abstract = {{A previous follow-up of the GINIplus study showed that breastfeeding could protect against early eczema. However, effects diminished in adolescence, possibly indicating a “rebound effect” in breastfed children after initial protection. We evaluated the role of early eczema until three years of age on allergies until young adulthood and assessed whether early eczema modifies the association between breastfeeding and allergies. Data from GINIplus until 20-years of age (N = 4058) were considered. Information on atopic eczema, asthma, and rhinitis was based on reported physician’s diagnoses. Adjusted Odds Ratios (aOR) were modelled by using generalized estimating equations. Early eczema was associated with eczema (aORs = 3.2–14.4), asthma (aORs = 2.2–2.7), and rhinitis (aORs = 1.2–2.7) until young adulthood. For eczema, this association decreased with age (p-for-interaction = 0.002–0.006). Longitudinal models did not show associations between breastfeeding and the respective allergies from 5 to 20 years of age. Moreover, early eczema generally did not modify the association between milk feeding and allergies except for rhinitis in participants without family history of atopy. Early eczema strongly predicts allergies until young adulthood. While preventive effects of full breastfeeding on eczema in infants with family history of atopy does not persist until young adulthood, the hypothesis of a rebound effect after initial protection cannot be confirmed.}}, author = {{Libuda, Lars and Filipiak-Pittroff, Birgit and Standl, Marie and Schikowski, Tamara and von Berg, Andrea and Koletzko, Sibylle and Bauer, Carl-Peter and Heinrich, Joachim and Berdel, Dietrich and Gappa, Monika}}, issn = {{2072-6643}}, journal = {{Nutrients}}, keywords = {{Food Science, Nutrition and Dietetics}}, number = {{12}}, publisher = {{MDPI AG}}, title = {{{Full Breastfeeding and Allergic Diseases—Long-Term Protection or Rebound Effects?}}}, doi = {{10.3390/nu15122780}}, volume = {{15}}, year = {{2023}}, } @article{50352, author = {{Kolbaum, AE and Jung, C and Jaeger, A and Libuda, Lars and Lindtner, O}}, issn = {{0278-6915}}, journal = {{Food Chem Toxicol}}, pages = {{114404}}, title = {{{Assessment of long-term dietary cadmium exposure in children in Germany: Does consideration of data from total diet studies reduce uncertainties from food monitoring programmes?}}}, volume = {{184}}, year = {{2023}}, } @article{33383, author = {{Bühlmeier, Judith and Frölich, Stefanie and Ludwig, Christine and Knoll-Pientka, Nadja and Schmidt, Börge and Föcker, Manuel and Libuda, Lars}}, issn = {{1436-6207}}, journal = {{European Journal of Nutrition}}, keywords = {{Nutrition and Dietetics, Medicine (miscellaneous)}}, number = {{6}}, pages = {{3307--3308}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Correction to: Changes in patterns of eating habits and food intake during the first German COVID-19 lockdown: results of a cross-sectional online survey}}}, doi = {{10.1007/s00394-022-02952-6}}, volume = {{61}}, year = {{2022}}, } @article{33382, author = {{Hirtz, Raphael and Libuda, Lars and Hinney, Anke and Föcker, Manuel and Bühlmeier, Judith and Holterhus, Paul-Martin and Kulle, Alexandra and Kiewert, Cordula and Kuhnert, Ronny and Cohrdes, Caroline and Peters, Triinu and Hebebrand, Johannes and Grasemann, Corinna}}, issn = {{0165-0327}}, journal = {{Journal of Affective Disorders}}, keywords = {{Psychiatry and Mental health, Clinical Psychology}}, pages = {{103--112}}, publisher = {{Elsevier BV}}, title = {{{Age at menarche relates to depression in adolescent girls: Comparing a clinical sample to the general pediatric population}}}, doi = {{10.1016/j.jad.2022.08.092}}, volume = {{318}}, year = {{2022}}, } @article{32326, abstract = {{AbstractGenetic factors are relevant for both eating disorders and body weight regulation. A recent genome-wide association study (GWAS) for anorexia nervosa (AN) detected eight genome-wide significant chromosomal loci. One of these loci, rs10747478, was also genome-wide and significantly associated with body mass index (BMI). The nearest coding gene is the Polypyrimidine Tract Binding Protein 2 gene (PTBP2). To detect mutations in PTBP2, Sanger sequencing of the coding region was performed in 192 female patients with AN (acute or recovered) and 191 children or adolescents with (extreme) obesity. Twenty-five variants were identified. Twenty-three of these were predicted to be pathogenic or functionally relevant in at least one in silico tool. Two novel synonymous variants (p.Ala77Ala and p.Asp195Asp), one intronic SNP (rs188987764), and the intronic deletion (rs561340981) located in the highly conserved region of PTBP2 may have functional consequences. Ten of 20 genes interacting with PTBP2 were studied for their impact on body weight regulation based on either previous functional studies or GWAS hits for body weight or BMI. In a GWAS for BMI (Pulit et al. 2018), the number of genome-wide significant associations at the PTBP2 locus was different between males (60 variants) and females (two variants, one of these also significant in males). More than 65% of these 61 variants showed differences in the effect size pertaining to BMI between sexes (absolute value of Z-score >2, two-sided p < 0.05). One LD block overlapping 5′UTR and all coding regions of PTBP2 comprises 56 significant variants in males. The analysis based on sex-stratified BMI GWAS summary statistics implies that PTBP2 may have a more pronounced effect on body weight regulation in males than in females.}}, author = {{Zheng, Yiran and Rajcsanyi, Luisa Sophie and Herpertz-Dahlmann, Beate and Seitz, Jochen and de Zwaan, Martina and Herzog, Wolfgang and Ehrlich, Stefan and Zipfel, Stephan and Giel, Katrin and Egberts, Karin and Burghardt, Roland and Föcker, Manuel and Al-Lahham, Saad and Peters, Triinu and Libuda, Lars and Antel, Jochen and Hebebrand, Johannes and Hinney, Anke}}, issn = {{2158-3188}}, journal = {{Translational Psychiatry}}, keywords = {{Biological Psychiatry, Cellular and Molecular Neuroscience, Psychiatry and Mental health}}, number = {{1}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{PTBP2 – a gene with relevance for both Anorexia nervosa and body weight regulation}}}, doi = {{10.1038/s41398-022-02018-5}}, volume = {{12}}, year = {{2022}}, } @article{32328, abstract = {{Abstract Purpose The COVID-19 pandemic and public measures have a direct impact on the nutrition situation; studies show changes in food consumption, eating behavior or body weight but complex pattern analyses of changes rarely exist. Methods During the first German lockdown, a web-based survey was conducted among adults. It included 33 questions about changes in food intake, eating habits and physical activity, as well as anthropometrics and sociodemographic factors. Patterns of change were calculated based on changes in food intake and eating habits using two-step cluster analysis. To identify influencing factors for assignment to the patterns of change, binary logistic regression analyses were performed. Results Data from 2103 participants (81% female, 40 ± 14 years) were considered for analysis. Increased stockpiling, cooking, and variation in preparation was reported by 50–70%. The constant pattern (C-P, 36%) reported little change besides the above. The health-oriented pattern (HO-P; 37%) reported eating more healthy foods, avoiding unhealthy foods, and eating less and less frequently. The emotional-driven pattern (ED-P; 28%) exhibits higher influence of emotions on eating behavior, less avoidance of unhealthy foods, and increased consumption of sweets, pastries, and alcohol. The odds of changing eating behavior either to HO-P or ED-P were higher in women, people with migration background, younger participants, and increased with BMI categories. Conclusion Both, the ED-P and HO-P, exhibit distinctive reactions in eating habits and food intake when dealing with a distressing experience. In subgroups, these may lead to disturbances in eating behavior and increase the risk for eating disorders and obesity. }}, author = {{Bühlmeier, Judith and Frölich, Stefanie and Ludwig, Christine and Knoll-Pientka, Nadja and Schmidt, Börge and Föcker, Manuel and Libuda, Lars}}, issn = {{1436-6207}}, journal = {{European Journal of Nutrition}}, keywords = {{Nutrition and Dietetics, Medicine (miscellaneous)}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Changes in patterns of eating habits and food intake during the first German COVID-19 lockdown: results of a cross-sectional online survey}}}, doi = {{10.1007/s00394-022-02919-7}}, year = {{2022}}, } @article{33235, abstract = {{Abstract Purpose We aimed to investigate whether parental and siblings’ sugar-sweetened beverage (SSB) intake had prospective impact on children’s SSB consumption, and the potential sex difference in these associations. Methods This study included a total of 904 children and their parents enrolled from 2004 to 2011 China Health and Nutrition Survey (CHNS) cohort study. SSB consumption information was estimated using a short dietary questionnaire and total energy intake was assessed with three-day 24-h dietary assessments at recruitment and follow-up surveys. Multivariate logistic or linear regression analyses were used to assess the association for SSB consumption between parents, siblings and children after adjusting for age, body mass index (BMI) z-score, household income and parental educational level. Results In this study, a majority (87.6%) of children consumed SSB. Among them, the median consumption of SSB was 70.3 ml/day per capita and 205.4 ml/day per consumer. Parental SSB consumption was relevant to children’s SSB consumption, and this association was more pronounced in boys than in girls. Meanwhile, fathers seemed to have a stronger impact on whether children consume SSB than mothers which was reflected by lower P and higher OR. Additionally, children’s SSB intake was prospectively associated with their older siblings’ SSB consumption (Pfor trend < 0.03). Conclusions Parental and older siblings’ SSB consumption was relevant to children’s SSB intake. Particularly, boys were more susceptible to parental impact than girls, and fathers seemed to have a greater influence on children than mothers. }}, author = {{Liu, Xue-Ting and Xiong, Jing-Yuan and Xu, Yu-Jie and Zhao, Li and Libuda, Lars and Cheng, Guo}}, issn = {{1436-6207}}, journal = {{European Journal of Nutrition}}, keywords = {{Nutrition and Dietetics, Medicine (miscellaneous)}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Prospective association of family members’ sugar-sweetened beverages intake with children’s sugar-sweetened beverages consumption in China}}}, doi = {{10.1007/s00394-022-02971-3}}, year = {{2022}}, } @article{33234, author = {{Adan, Roger A.H. and Cirulli, Francesca and Dye, Louise and Higgs, Suzanne and Aarts, Kristien and van der Beek, Eline M. and Buitelaar, Jan K. and Destrebecq, Frédéric and De Witte, Elke and Hartmann, Tobias and Korosi, Aniko and Libuda, Lars and Dickson, Suzanne L.}}, issn = {{0889-1591}}, journal = {{Brain, Behavior, and Immunity}}, keywords = {{Behavioral Neuroscience, Endocrine and Autonomic Systems, Immunology}}, pages = {{201--203}}, publisher = {{Elsevier BV}}, title = {{{Towards new nutritional policies for brain health: A research perspective on future actions}}}, doi = {{10.1016/j.bbi.2022.07.012}}, volume = {{105}}, year = {{2022}}, } @article{33385, abstract = {{Abstract Background In Sub-Saharan African countries, rapid urbanization and increasing socio-economic status are associated with a transition to decreased physical activity (PA). A more sedentary lifestyle is linked to increased body fat leading to increments in leptin levels. Since rodent and human studies in high-income countries have shown that starvation-induced hypoleptinemia triggers high PA, efforts are warranted to pursue the hypothesis that low leptin levels in lean children of low- and middle-income countries (LMIC) are also associated with high PA. Methods In this cross-sectional study, we assessed seven-day PA with triaxial accelerometry (ActiGraph GT3X) among 223 primary school children (9 to 12 years of age) in rural Tanzania. Moderate-to-vigorous PA (MVPA) and total accelerometer counts per day were outcome variables. Leptin was determined using enzyme linked immunosorbent assay tests from dried blood spots. Anthropometric assessments were conducted and food insecurity and socio-demographic data were gathered using semi-structured interviews. Results In this sample of school children in rural Tanzania, leptin concentrations (median: 0.91 ng/mL, P25: 0.55, P75: 1.69), body mass index z-scores (median: -1.35, P25: -1.93, P75: -0.82), and height-for-age-z-scores (median: -1.16, P25: -1.96, P75: -0.61) were low. In contrast, PA levels were high with a median MVPA time of 119 min/day. Linear regression confirmed that leptin levels were negatively associated with MVPA (beta: -18.1; 95%CI: -29.7; -6.5; p = 0.002) and total accelerometer counts (beta: -90,256; 95%CI: -154,146; -26,365; p = 0.006). Children residing in areas with better infrastructure had lower MVPA levels (p < 0.001) and tended to have higher leptin levels (p = 0.062) than children residing in areas only reachable via dirt roads. Conclusion Our cross-sectional field study is the first that supports the hypothesis of low leptin levels as a potential endocrine trigger of high PA in lean children of a LMIC. We observed early signs of a PA transition towards a less active lifestyle in a subgroup residing in areas with better infrastructure that concomitantly tended to have higher leptin concentrations. Considering that area-dependent PA differences were more pronounced among girls than boys, whereas differences in leptin levels were less pronounced, not only biological, but also external factors explain PA transition. }}, author = {{Ludwig, Christine and Knoll-Pientka, Nadja and Mwanri, Akwilina and Erfle, Celina and Onywera, Vincent and Tremblay, Mark S. and Bühlmeier, Judith and Luzak, Agnes and Ferland, Maike and Schulz, Holger and Libuda, Lars and Hebebrand, Johannes}}, issn = {{1471-2458}}, journal = {{BMC Public Health}}, keywords = {{Public Health, Environmental and Occupational Health}}, number = {{1}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Low leptin levels are associated with elevated physical activity among lean school children in rural Tanzania}}}, doi = {{10.1186/s12889-022-12949-9}}, volume = {{22}}, year = {{2022}}, } @article{33386, abstract = {{Abstract Background/objectives The transition to adolescence is characterised by considerable behavioural changes, including diet. This study describes the level of obesogenic eating behaviours in 10- and 15-year-olds, and their association with dietary intake. Subjects/methods Participants of the 10- and 15-year follow-ups of the German GINIplus and LISA birth cohort studies were included (N10 = 2257; N15 = 1880). Eating behaviours and dietary intake were assessed via self-report questionnaires. Sex-stratified, cross-sectional associations of “external eating”, “emotional eating” and “dietary restraint” (the latter at age 15 years only) with dietary intake (17 food groups—categorised into tertiles, macronutrients, and total energy) were assessed using multinomial logistic or multiple linear regression as required, adjusting for covariates and correcting for multiple testing. Results Reported levels of eating behaviours were low in both age-groups. External eating was higher in 10-year-old males than females, while all eating behaviours were most pronounced in 15-year-old females. At 10 years, emotional eating was associated with medium vegetable intake in females (Relative Risk Ratio (RRR) = 1.84, p = 0.0017). At 15 years, external eating was associated with total energy (kJ) in females (β = 718, p = 0.0002) and high butter intake in males (RRR = 1.96, p = 0.0019). Dietary restraint in females was inversely associated with total energy (β = −967, p < 0.0001) and omega-3 fatty acids (Means Ratio (MR) = 0.94, p = 0.0017), and positively associated with high fruit (RRR = 2.20, p = 0.0003) and whole grains (RRR = 1.94, p = 0.0013). Conclusion Obesogenic eating behaviour scores are low among children and adolescents of a predominantly high socioeconomic status population and present only few associations with specific aspects of diet, mainly among adolescent females. }}, author = {{Marb, Anne and Libuda, Lars and Standl, Marie and Koletzko, Sibylle and Bauer, Carl-Peter and Schikowski, Tamara and Berdel, Dietrich and von Berg, Andrea and Herberth, Gunda and Bühlmeier, Judith and Harris, Carla P.}}, issn = {{0954-3007}}, journal = {{European Journal of Clinical Nutrition}}, keywords = {{Nutrition and Dietetics, Medicine (miscellaneous)}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{Obesogenic eating behaviour and dietary intake in German children and adolescents: results from the GINIplus and LISA birth cohort studies}}}, doi = {{10.1038/s41430-022-01125-2}}, year = {{2022}}, } @article{35311, author = {{Jansen, K and Tempes, J and Drozdowska, A and Gutmann, M and Falkenstein, M and Buyken, Anette and Libuda, Lars and Rudolf, H and Lücke, T and Kersting, M}}, issn = {{0954-3007}}, journal = {{Eur J Clin Nutr}}, number = {{5}}, pages = {{779}}, title = {{{Correction: Short-term effects of carbohydrates differing in glycemic index (GI) consumed at lunch on children's cognitive function in a randomized crossover study.}}}, volume = {{76}}, year = {{2022}}, } @article{32327, abstract = {{AbstractThere is preliminary evidence that adrenal steroids other than cortisol may be valuable biomarkers for major depressive disorder (MDD). So far, studies have been conducted in adults only, and conclusions are limited, mainly due to small sample sizes. Therefore, the present study assessed whether adrenal steroids serve as biomarkers for adolescent MDD. In 261 depressed adolescents (170 females) treated at a single psychiatric hospital, serum adrenal steroids (progesterone, 17-hydroxyprogesterone, 21-deoxycortisol, 11-deoxycortisol, cortisol, cortisone, deoxycorticosterone, corticosterone) were determined by liquid chromatography-tandem mass spectrometry. Findings were compared to that of an age- and sex-matched reference cohort (N = 255) by nonparametric analysis of variance. Nonparametric receiver operating characteristics (ROC) analyses were conducted to evaluate the diagnostic performance of single steroids and steroid ratios to classify depression status. Sensitivity analyses considered important confounders of adrenal functioning, and ROC results were verified by cross-validation. Compared to the reference cohort, levels of deoxycorticosterone and 21-deoxycortisol were decreased (P < 0.001). All other glucocorticoid- and mineralocorticoid-related steroids were increased (P < 0.001). The corticosterone to deoxycorticosterone ratio evidenced excellent classification characteristics, especially in females (AUC: 0.957; sensitivity: 0.902; specificity: 0.891). The adrenal steroid metabolome qualifies as a bio-readout reflecting adolescent MDD by a distinct steroid pattern that indicates dysfunction of the hypothalamus–pituitary–adrenal axis. Moreover, the corticosterone to deoxycorticosterone ratio may prospectively qualify to contribute to precision medicine in psychiatry by identifying those patients who might benefit from antiglucocorticoid treatment or those at risk for recurrence when adrenal dysfunction has not resolved.}}, author = {{Hirtz, Raphael and Libuda, Lars and Hinney, Anke and Föcker, Manuel and Bühlmeier, Judith and Holterhus, Paul-Martin and Kulle, Alexandra and Kiewert, Cordula and Hauffa, Berthold P. and Hebebrand, Johannes and Grasemann, Corinna}}, issn = {{2158-3188}}, journal = {{Translational Psychiatry}}, keywords = {{Biological Psychiatry, Cellular and Molecular Neuroscience, Psychiatry and Mental health}}, number = {{1}}, publisher = {{Springer Science and Business Media LLC}}, title = {{{The adrenal steroid profile in adolescent depression: a valuable bio-readout?}}}, doi = {{10.1038/s41398-022-01966-2}}, volume = {{12}}, year = {{2022}}, } @article{26420, author = {{Hirtz, Raphael and Focker, Manuel and Libuda, Lars and Antel, Jochen and Ozturk, Dana and Kiewert, Cordula and Munteanu, Martin and Peters, Triinu and Fuhrer, Dagmar and Zwanziger, Denise and Thamm, Michael and Hebebrand, Johannes and Grasemann, Corinna}}, issn = {{1555-2101}}, journal = {{The Journal of Clinical Psychiatry}}, title = {{{Increased Prevalence of Subclinical Hypothyroidism and Thyroid Autoimmunity in Depressed Adolescents}}}, doi = {{10.4088/jcp.20m13511}}, year = {{2021}}, } @article{26523, abstract = {{AbstractWith this case report we support our medical hypothesis that metreleptin treatment ameliorates starvation related emotional, cognitive and behavioral symptomatology of anorexia nervosa (AN) and show for the first time strong effects in a male patient with AN. A 15.9 year old adolescent with severe AN of eight-month duration was treated off-label with metreleptin. Hyperactivity was assessed with accelerometry. Visual analogue scales (VAS), validated self- and clinician rating scales and lab results tracked changes from baseline to end of the 24-day dosing period and a five-month follow-up. Substantial improvements of mood and eating disorder related cognitions and hyperactivity set in after two days of treatment. During dosing, sub-physiological testosterone and TT3 levels normalized; clinically libido reemerged. Weight did not increase substantially during the dosing period. During follow-up target weight was attained; mood did not deteriorate; hyperactivity ceased. The results substantiate the strong effects seen in female cases and underscore the need for a double-blind placebo-controlled trial to confirm the observed strong, multiple and rapid onset beneficial effects of metreleptin in AN.}}, author = {{Antel, Jochen and Tan, Susanne and Grabler, Marvin and Ludwig, Christine and Lohkemper, Dominik and Brandenburg, Tim and Barth, Nikolaus and Hinney, Anke and Libuda, Lars and Remy, Miriam and Milos, Gabriella and Hebebrand, Johannes}}, issn = {{1018-8827}}, journal = {{European Child & Adolescent Psychiatry}}, title = {{{Rapid amelioration of anorexia nervosa in a male adolescent during metreleptin treatment including recovery from hypogonadotropic hypogonadism}}}, doi = {{10.1007/s00787-021-01778-7}}, year = {{2021}}, } @article{27572, abstract = {{ Zusammenfassung. Genetische Varianten beeinflussen die Gewichtsregulation und die Entwicklung von Essstörungen. Zunächst haben familienbasierte, sogenannte formalgenetische Studien den erblichen Anteil an der Gewichtsregulation und an der Ätiologie von Essstörungen beleuchtet. In einer Vielzahl von Studien zeigten sich sowohl für die Varianz des Körpergewichts als auch für die Entstehung von Essstörungen Erblichkeitsschätzer (Heritabilitätsraten) von über 50 %. Mit diesem Wissen begab man sich in den 90er-Jahren des letzten Jahrhunderts auf die Suche nach den zugrundeliegenden Genen (genauer: genetischen Varianten), die das Körpergewicht, das Essverhalten oder beide Phänotypen auf Grundlage geteilter Mechanismen beeinflussen. Zunächst wurden Kandidatengenstudien durchgeführt. Dabei untersuchte man auf Grundlage unterschiedlicher, v. a. aber pathophysiologisch plausibler Überlegungen Gene mit hoher Relevanz für die untersuchten Phänotypen. Dieser Ansatz war für Essstörungen nicht sehr erfolgreich, für die Gewichtsregulation konnte eine Handvoll Gene identifiziert werden. Verbunden mit großen methodischen Fortschritten in der genetischen Forschung und v. a. der Etablierung sogenannter genomweiter Assoziationsstudien (GWAS) Anfang der 2000er-Jahre konnten bislang über 1000 Varianten/Genorte detektiert werden, die das Körpergewicht beeinflussen. Für die Essstörung Anorexia nervosa (AN) sind aktuell acht solcher Genorte beschrieben. Diese Ergebnisse, aber auch aktuelle Ansätze zu phänotypübergreifenden Analysen lassen Einblicke in die komplexe Regulation des Körpergewichtes zu und haben zudem unerwartete Pathomechanismen für AN aufgezeigt. }}, author = {{Hirtz, Raphael and Zheng, Yiran and Rajcsanyi, Luisa S. and Libuda, Lars and Antel, Jochen and Peters, Triinu and Hebebrand, Johannes and Hinney, Anke}}, issn = {{1422-4917}}, journal = {{Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie}}, title = {{{Ebenen der genetischen Analyse komplexer Phänotypen am Beispiel der Anorexia nervosa und der Varianz des Körpergewichts}}}, doi = {{10.1024/1422-4917/a000829}}, year = {{2021}}, } @article{27573, abstract = {{ Zusammenfassung. Einleitung: Klassische ernährungsepidemiologische Studien (Beobachtungsstudien und randomisierte Interventionsstudien) zeigen, dass die Ernährung ein wichtiger Ansatzpunkt für die Prävention und Therapie psychischer Störungen sein könnte. Diese Studientypen haben allerdings Limitationen, die bei der Ergebnisinterpretation berücksichtigt werden müssen. In dieser narrativen übersichtsarbeit wird beschrieben, wie genetische Studien ein Bindeglied darstellen können, um einen Zusammenhang zwischen Ernährung und psychischen Störungen herzustellen. Methodik: Im Artikel werden verschiedene Ansätze genetischer phänotypübergreifender Analysen sowie Beispiele für deren Anwendungen in der ernährungspsychiatrischen Forschung beschrieben. Darüber hinaus werden spezifische Voraussetzungen sowie Stärken und Schwächen diskutiert. Ergebnisse: Als Methoden genetischer phänotypübergreifender Analysen sind im Rahmen ernährungspsychiatrischer Forschung bislang genetische Korrelationsanalysen, Look-up-Analysen sowie Mendelsche Randomisierungsstudien (MR-Studien) eingesetzt worden. Genetische Korrelationsanalysen und Look-up-Analysen geben erste Hinweise auf mögliche genetische überlappungen zwischen einer psychischen Störung und einem Stoffwechselweg und/oder der Versorgung mit einem spezifischen Nährstoff. MR-Studien sind weitergehende Detailanalysen mit dem Ziel, Kausalzusammenhänge zu identifizieren, beinhalten allerdings sehr spezifische Grundvoraussetzungen für ihre Durchführung. Schlussfolgerung: Genetische phänotypübergreifende Analysen sind eine sinnvolle Ergänzung der klassischen Ernährungsepidemiologie. Insbesondere signifikante Ergebnisse von MR-Studien sind eine wichtige Grundlage zur Entwicklung geeigneter Ernährungsinterventionen, die in nachfolgenden randomisiert kontrollierten Interventionsstudien mit deutlich erhöhter Erfolgsaussicht getestet werden können. Sie sind somit wichtige Instrumente einer effizienten ernährungspsychiatrischen Forschung. }}, author = {{Libuda, Lars and Hebebrand, Johannes and Föcker, Manuel and Peters, Triinu and Hinney, Anke}}, issn = {{1422-4917}}, journal = {{Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie}}, pages = {{1--10}}, title = {{{Ernährungseffekten auf der Spur – Wie die Genetik helfen kann, Zusammenhänge zwischen Ernährung und seelischer Gesundheit aufzudecken}}}, doi = {{10.1024/1422-4917/a000807}}, year = {{2021}}, }