--- _id: '65374' article_number: '109' author: - first_name: Laura full_name: Schlarbaum, Laura id: '96697' last_name: Schlarbaum - first_name: Nicole full_name: Jankovic, Nicole id: '105192' last_name: Jankovic orcid: https://orcid.org/0000-0002-9235-5356 - first_name: Judith full_name: Bühlmeier, Judith id: '89838' last_name: Bühlmeier - first_name: Eva full_name: Hohoff, Eva last_name: Hohoff - first_name: Rhea full_name: Dankers, Rhea id: '64668' last_name: Dankers - first_name: Harald full_name: Engler, Harald last_name: Engler - first_name: Raphael full_name: Hirtz, Raphael last_name: Hirtz - first_name: Denise full_name: Zwanziger, Denise last_name: Zwanziger - first_name: Corinna full_name: Grasemann, Corinna last_name: Grasemann - first_name: Triinu full_name: Peters, Triinu last_name: Peters - first_name: Anke full_name: Hinney, Anke last_name: Hinney - first_name: Jochen full_name: Antel, Jochen last_name: Antel - first_name: Manuel full_name: Föcker, Manuel last_name: Föcker - first_name: Lars full_name: Libuda, Lars id: '88682' last_name: Libuda orcid: 0000-0003-1603-3133 citation: ama: Schlarbaum L, Jankovic N, Bühlmeier J, et al. Does inflammation moderate the effect of vitamin D supplementation on depressive symptoms? Results of an interventional study in children and adolescents. European Journal of Nutrition. 2026;65(3). doi:10.1007/s00394-026-03920-0 apa: Schlarbaum, L., Jankovic, N., Bühlmeier, J., Hohoff, E., Dankers, R., Engler, H., Hirtz, R., Zwanziger, D., Grasemann, C., Peters, T., Hinney, A., Antel, J., Föcker, M., & Libuda, L. (2026). Does inflammation moderate the effect of vitamin D supplementation on depressive symptoms? Results of an interventional study in children and adolescents. European Journal of Nutrition, 65(3), Article 109. https://doi.org/10.1007/s00394-026-03920-0 bibtex: '@article{Schlarbaum_Jankovic_Bühlmeier_Hohoff_Dankers_Engler_Hirtz_Zwanziger_Grasemann_Peters_et al._2026, title={Does inflammation moderate the effect of vitamin D supplementation on depressive symptoms? Results of an interventional study in children and adolescents}, volume={65}, DOI={10.1007/s00394-026-03920-0}, number={3109}, journal={European Journal of Nutrition}, publisher={Springer Science and Business Media LLC}, author={Schlarbaum, Laura and Jankovic, Nicole and Bühlmeier, Judith and Hohoff, Eva and Dankers, Rhea and Engler, Harald and Hirtz, Raphael and Zwanziger, Denise and Grasemann, Corinna and Peters, Triinu and et al.}, year={2026} }' chicago: Schlarbaum, Laura, Nicole Jankovic, Judith Bühlmeier, Eva Hohoff, Rhea Dankers, Harald Engler, Raphael Hirtz, et al. “Does Inflammation Moderate the Effect of Vitamin D Supplementation on Depressive Symptoms? Results of an Interventional Study in Children and Adolescents.” European Journal of Nutrition 65, no. 3 (2026). https://doi.org/10.1007/s00394-026-03920-0. ieee: 'L. Schlarbaum et al., “Does inflammation moderate the effect of vitamin D supplementation on depressive symptoms? Results of an interventional study in children and adolescents,” European Journal of Nutrition, vol. 65, no. 3, Art. no. 109, 2026, doi: 10.1007/s00394-026-03920-0.' mla: Schlarbaum, Laura, et al. “Does Inflammation Moderate the Effect of Vitamin D Supplementation on Depressive Symptoms? Results of an Interventional Study in Children and Adolescents.” European Journal of Nutrition, vol. 65, no. 3, 109, Springer Science and Business Media LLC, 2026, doi:10.1007/s00394-026-03920-0. short: L. Schlarbaum, N. Jankovic, J. Bühlmeier, E. Hohoff, R. Dankers, H. Engler, R. Hirtz, D. Zwanziger, C. Grasemann, T. Peters, A. Hinney, J. Antel, M. Föcker, L. Libuda, European Journal of Nutrition 65 (2026). date_created: 2026-04-08T09:04:52Z date_updated: 2026-04-15T08:57:13Z ddc: - '570' doi: 10.1007/s00394-026-03920-0 file: - access_level: closed content_type: application/pdf creator: laura36 date_created: 2026-04-08T09:15:10Z date_updated: 2026-04-08T09:15:10Z file_id: '65377' file_name: 394_2026_Article_3920.pdf file_size: 939647 relation: main_file success: 1 file_date_updated: 2026-04-08T09:15:10Z has_accepted_license: '1' intvolume: ' 65' issue: '3' language: - iso: eng publication: European Journal of Nutrition publication_identifier: issn: - 1436-6207 - 1436-6215 publication_status: published publisher: Springer Science and Business Media LLC status: public title: Does inflammation moderate the effect of vitamin D supplementation on depressive symptoms? Results of an interventional study in children and adolescents type: journal_article user_id: '96697' volume: 65 year: '2026' ... --- _id: '65375' abstract: - lang: eng text: "Abstract\r\n Vitamin D has been associated with depression, potentially via anti-inflammatory mechanisms, yet data is scarce, particularly in adolescence. We investigated (1) whether lower vitamin D status is associated with greater depression severity and (2) whether this association is statistically moderated by inflammation in patients of a child and adolescent psychiatry department. At admission fasting morning venous blood was drawn. Serum vitamin D (25(OH)D) and C-reactive protein (CRP) were analyzed in all participants [n=465 (64.7%♀; 11.3-18.9 years)]. In a subsample [n=177], we additionally measured tumor necrosis factor-alpha, interferon-gamma and interleukin (IL)-1β, IL-6, IL-8, IL-10. Depression severity was assessed by the Beck Depression Inventory-II (BDI-II) [n=450], the Diagnostic System for Mental Disorders in Childhood and Adolescence via self-assessment (DISYPS Self) [n=441], and parent-assessment (DISYPS Proxy) [n=422]. Overall, 43.2% [n=201] were at risk for vitamin D deficiency (<30nmol/L), and 73.5%-83.2% –depending on assessment tool– showed at least mild depression. Linear regression revealed an inverse association between 25(OH)D and BDI-II in both crude and CRP-adjusted full-sample models. Logistic regressions showed a robust inverse association between 25(OH)D and DISYPS Proxy, but not for DISYPS Self. Although 25(OH)D was inversely correlated with some pro-inflammatory markers, neither their inclusion in regression models nor formal mediation analyses supported inflammation as a mediator of the vitamin D–depression association. Overall, our results suggest that vitamin D relates modestly to both depression and inflammation in adolescence. However, based on the measured parameters, we cannot confirm that anti-inflammatory effects are the link between vitamin D and depression." article_type: original author: - first_name: Laura full_name: Schlarbaum, Laura id: '96697' last_name: Schlarbaum - first_name: Nicole full_name: Jankovic, Nicole id: '105192' last_name: Jankovic orcid: https://orcid.org/0000-0002-9235-5356 - first_name: Judith full_name: Bühlmeier, Judith id: '89838' last_name: Bühlmeier - first_name: Harald full_name: Engler, Harald last_name: Engler - first_name: Raphael full_name: Hirtz, Raphael last_name: Hirtz - first_name: Corinna full_name: Grasemann, Corinna last_name: Grasemann - first_name: Triinu full_name: Peters, Triinu last_name: Peters - first_name: Anke full_name: Hinney, Anke last_name: Hinney - first_name: Jochen full_name: Antel, Jochen last_name: Antel - first_name: Johannes full_name: Hebebrand, Johannes last_name: Hebebrand - first_name: Manuel full_name: Föcker, Manuel last_name: Föcker - first_name: Lars full_name: Libuda, Lars id: '88682' last_name: Libuda orcid: 0000-0003-1603-3133 citation: ama: Schlarbaum L, Jankovic N, Bühlmeier J, et al. Does inflammation explain the association between vitamin D and depression? Results of a cross-sectional study in children and adolescents. British Journal of Nutrition. Published online 2026:1-37. doi:10.1017/s0007114526106928 apa: Schlarbaum, L., Jankovic, N., Bühlmeier, J., Engler, H., Hirtz, R., Grasemann, C., Peters, T., Hinney, A., Antel, J., Hebebrand, J., Föcker, M., & Libuda, L. (2026). Does inflammation explain the association between vitamin D and depression? Results of a cross-sectional study in children and adolescents. British Journal of Nutrition, 1–37. https://doi.org/10.1017/s0007114526106928 bibtex: '@article{Schlarbaum_Jankovic_Bühlmeier_Engler_Hirtz_Grasemann_Peters_Hinney_Antel_Hebebrand_et al._2026, title={Does inflammation explain the association between vitamin D and depression? Results of a cross-sectional study in children and adolescents}, DOI={10.1017/s0007114526106928}, journal={British Journal of Nutrition}, publisher={Cambridge University Press (CUP)}, author={Schlarbaum, Laura and Jankovic, Nicole and Bühlmeier, Judith and Engler, Harald and Hirtz, Raphael and Grasemann, Corinna and Peters, Triinu and Hinney, Anke and Antel, Jochen and Hebebrand, Johannes and et al.}, year={2026}, pages={1–37} }' chicago: Schlarbaum, Laura, Nicole Jankovic, Judith Bühlmeier, Harald Engler, Raphael Hirtz, Corinna Grasemann, Triinu Peters, et al. “Does Inflammation Explain the Association between Vitamin D and Depression? Results of a Cross-Sectional Study in Children and Adolescents.” British Journal of Nutrition, 2026, 1–37. https://doi.org/10.1017/s0007114526106928. ieee: 'L. Schlarbaum et al., “Does inflammation explain the association between vitamin D and depression? Results of a cross-sectional study in children and adolescents,” British Journal of Nutrition, pp. 1–37, 2026, doi: 10.1017/s0007114526106928.' mla: Schlarbaum, Laura, et al. “Does Inflammation Explain the Association between Vitamin D and Depression? Results of a Cross-Sectional Study in Children and Adolescents.” British Journal of Nutrition, Cambridge University Press (CUP), 2026, pp. 1–37, doi:10.1017/s0007114526106928. short: L. Schlarbaum, N. Jankovic, J. Bühlmeier, H. Engler, R. Hirtz, C. Grasemann, T. Peters, A. Hinney, J. Antel, J. Hebebrand, M. Föcker, L. Libuda, British Journal of Nutrition (2026) 1–37. date_created: 2026-04-08T09:06:17Z date_updated: 2026-04-28T14:24:58Z ddc: - '570' doi: 10.1017/s0007114526106928 file: - access_level: closed content_type: application/pdf creator: laura36 date_created: 2026-04-28T14:24:22Z date_updated: 2026-04-28T14:24:22Z file_id: '65504' file_name: does-inflammation-explain-the-association-between-vitamin-d-and-depression-results-of-a-cross-sectional-study-in-children-and-adolescents.pdf file_size: 715441 relation: main_file success: 1 file_date_updated: 2026-04-28T14:24:22Z has_accepted_license: '1' language: - iso: eng page: 1-37 publication: British Journal of Nutrition publication_identifier: issn: - 0007-1145 - 1475-2662 publication_status: published publisher: Cambridge University Press (CUP) status: public title: Does inflammation explain the association between vitamin D and depression? Results of a cross-sectional study in children and adolescents type: journal_article user_id: '96697' year: '2026' ... --- _id: '33383' author: - first_name: Judith full_name: Bühlmeier, Judith id: '89838' last_name: Bühlmeier - first_name: Stefanie full_name: Frölich, Stefanie last_name: Frölich - first_name: Christine full_name: Ludwig, Christine last_name: Ludwig - first_name: Nadja full_name: Knoll-Pientka, Nadja last_name: Knoll-Pientka - first_name: Börge full_name: Schmidt, Börge last_name: Schmidt - first_name: Manuel full_name: Föcker, Manuel last_name: Föcker - first_name: Lars full_name: Libuda, Lars id: '88682' last_name: Libuda orcid: 0000-0003-1603-3133 citation: ama: 'Bühlmeier J, Frölich S, Ludwig C, et al. Correction to: Changes in patterns of eating habits and food intake during the first German COVID-19 lockdown: results of a cross-sectional online survey. European Journal of Nutrition. 2022;61(6):3307-3308. doi:10.1007/s00394-022-02952-6' apa: 'Bühlmeier, J., Frölich, S., Ludwig, C., Knoll-Pientka, N., Schmidt, B., Föcker, M., & Libuda, L. (2022). Correction to: Changes in patterns of eating habits and food intake during the first German COVID-19 lockdown: results of a cross-sectional online survey. European Journal of Nutrition, 61(6), 3307–3308. https://doi.org/10.1007/s00394-022-02952-6' bibtex: '@article{Bühlmeier_Frölich_Ludwig_Knoll-Pientka_Schmidt_Föcker_Libuda_2022, title={Correction to: Changes in patterns of eating habits and food intake during the first German COVID-19 lockdown: results of a cross-sectional online survey}, volume={61}, DOI={10.1007/s00394-022-02952-6}, number={6}, journal={European Journal of Nutrition}, publisher={Springer Science and Business Media LLC}, author={Bühlmeier, Judith and Frölich, Stefanie and Ludwig, Christine and Knoll-Pientka, Nadja and Schmidt, Börge and Föcker, Manuel and Libuda, Lars}, year={2022}, pages={3307–3308} }' chicago: 'Bühlmeier, Judith, Stefanie Frölich, Christine Ludwig, Nadja Knoll-Pientka, Börge Schmidt, Manuel Föcker, and Lars Libuda. “Correction to: Changes in Patterns of Eating Habits and Food Intake during the First German COVID-19 Lockdown: Results of a Cross-Sectional Online Survey.” European Journal of Nutrition 61, no. 6 (2022): 3307–8. https://doi.org/10.1007/s00394-022-02952-6.' ieee: 'J. Bühlmeier et al., “Correction to: Changes in patterns of eating habits and food intake during the first German COVID-19 lockdown: results of a cross-sectional online survey,” European Journal of Nutrition, vol. 61, no. 6, pp. 3307–3308, 2022, doi: 10.1007/s00394-022-02952-6.' mla: 'Bühlmeier, Judith, et al. “Correction to: Changes in Patterns of Eating Habits and Food Intake during the First German COVID-19 Lockdown: Results of a Cross-Sectional Online Survey.” European Journal of Nutrition, vol. 61, no. 6, Springer Science and Business Media LLC, 2022, pp. 3307–08, doi:10.1007/s00394-022-02952-6.' short: J. Bühlmeier, S. Frölich, C. Ludwig, N. Knoll-Pientka, B. Schmidt, M. Föcker, L. Libuda, European Journal of Nutrition 61 (2022) 3307–3308. date_created: 2022-09-15T09:17:02Z date_updated: 2022-09-15T09:46:35Z department: - _id: '17' doi: 10.1007/s00394-022-02952-6 intvolume: ' 61' issue: '6' keyword: - Nutrition and Dietetics - Medicine (miscellaneous) language: - iso: eng page: 3307-3308 publication: European Journal of Nutrition publication_identifier: issn: - 1436-6207 - 1436-6215 publication_status: published publisher: Springer Science and Business Media LLC status: public title: 'Correction to: Changes in patterns of eating habits and food intake during the first German COVID-19 lockdown: results of a cross-sectional online survey' type: journal_article user_id: '89838' volume: 61 year: '2022' ... --- _id: '33382' author: - first_name: Raphael full_name: Hirtz, Raphael last_name: Hirtz - first_name: Lars full_name: Libuda, Lars id: '88682' last_name: Libuda orcid: 0000-0003-1603-3133 - first_name: Anke full_name: Hinney, Anke last_name: Hinney - first_name: Manuel full_name: Föcker, Manuel last_name: Föcker - first_name: Judith full_name: Bühlmeier, Judith id: '89838' last_name: Bühlmeier - first_name: Paul-Martin full_name: Holterhus, Paul-Martin last_name: Holterhus - first_name: Alexandra full_name: Kulle, Alexandra last_name: Kulle - first_name: Cordula full_name: Kiewert, Cordula last_name: Kiewert - first_name: Ronny full_name: Kuhnert, Ronny last_name: Kuhnert - first_name: Caroline full_name: Cohrdes, Caroline last_name: Cohrdes - first_name: Triinu full_name: Peters, Triinu last_name: Peters - first_name: Johannes full_name: Hebebrand, Johannes last_name: Hebebrand - first_name: Corinna full_name: Grasemann, Corinna last_name: Grasemann citation: ama: 'Hirtz R, Libuda L, Hinney A, et al. Age at menarche relates to depression in adolescent girls: Comparing a clinical sample to the general pediatric population. Journal of Affective Disorders. 2022;318:103-112. doi:10.1016/j.jad.2022.08.092' apa: 'Hirtz, R., Libuda, L., Hinney, A., Föcker, M., Bühlmeier, J., Holterhus, P.-M., Kulle, A., Kiewert, C., Kuhnert, R., Cohrdes, C., Peters, T., Hebebrand, J., & Grasemann, C. (2022). Age at menarche relates to depression in adolescent girls: Comparing a clinical sample to the general pediatric population. Journal of Affective Disorders, 318, 103–112. https://doi.org/10.1016/j.jad.2022.08.092' bibtex: '@article{Hirtz_Libuda_Hinney_Föcker_Bühlmeier_Holterhus_Kulle_Kiewert_Kuhnert_Cohrdes_et al._2022, title={Age at menarche relates to depression in adolescent girls: Comparing a clinical sample to the general pediatric population}, volume={318}, DOI={10.1016/j.jad.2022.08.092}, journal={Journal of Affective Disorders}, publisher={Elsevier BV}, author={Hirtz, Raphael and Libuda, Lars and Hinney, Anke and Föcker, Manuel and Bühlmeier, Judith and Holterhus, Paul-Martin and Kulle, Alexandra and Kiewert, Cordula and Kuhnert, Ronny and Cohrdes, Caroline and et al.}, year={2022}, pages={103–112} }' chicago: 'Hirtz, Raphael, Lars Libuda, Anke Hinney, Manuel Föcker, Judith Bühlmeier, Paul-Martin Holterhus, Alexandra Kulle, et al. “Age at Menarche Relates to Depression in Adolescent Girls: Comparing a Clinical Sample to the General Pediatric Population.” Journal of Affective Disorders 318 (2022): 103–12. https://doi.org/10.1016/j.jad.2022.08.092.' ieee: 'R. Hirtz et al., “Age at menarche relates to depression in adolescent girls: Comparing a clinical sample to the general pediatric population,” Journal of Affective Disorders, vol. 318, pp. 103–112, 2022, doi: 10.1016/j.jad.2022.08.092.' mla: 'Hirtz, Raphael, et al. “Age at Menarche Relates to Depression in Adolescent Girls: Comparing a Clinical Sample to the General Pediatric Population.” Journal of Affective Disorders, vol. 318, Elsevier BV, 2022, pp. 103–12, doi:10.1016/j.jad.2022.08.092.' short: R. Hirtz, L. Libuda, A. Hinney, M. Föcker, J. Bühlmeier, P.-M. Holterhus, A. Kulle, C. Kiewert, R. Kuhnert, C. Cohrdes, T. Peters, J. Hebebrand, C. Grasemann, Journal of Affective Disorders 318 (2022) 103–112. date_created: 2022-09-15T09:15:58Z date_updated: 2022-09-15T09:48:03Z department: - _id: '17' doi: 10.1016/j.jad.2022.08.092 extern: '1' intvolume: ' 318' keyword: - Psychiatry and Mental health - Clinical Psychology language: - iso: eng page: 103-112 publication: Journal of Affective Disorders publication_identifier: issn: - 0165-0327 publication_status: published publisher: Elsevier BV status: public title: 'Age at menarche relates to depression in adolescent girls: Comparing a clinical sample to the general pediatric population' type: journal_article user_id: '89838' volume: 318 year: '2022' ... --- _id: '32328' abstract: - lang: eng text: "Abstract\r\n Purpose\r\n \ The COVID-19 pandemic and public measures have a direct impact on the nutrition situation; studies show changes in food consumption, eating behavior or body weight but complex pattern analyses of changes rarely exist.\r\n \ \r\n Methods\r\n \ During the first German lockdown, a web-based survey was conducted among adults. It included 33 questions about changes in food intake, eating habits and physical activity, as well as anthropometrics and sociodemographic factors. Patterns of change were calculated based on changes in food intake and eating habits using two-step cluster analysis. To identify influencing factors for assignment to the patterns of change, binary logistic regression analyses were performed.\r\n \r\n Results\r\n \ Data from 2103 participants (81% female, 40 ± 14 years) were considered for analysis. Increased stockpiling, cooking, and variation in preparation was reported by 50–70%. The constant pattern (C-P, 36%) reported little change besides the above. The health-oriented pattern (HO-P; 37%) reported eating more healthy foods, avoiding unhealthy foods, and eating less and less frequently. The emotional-driven pattern (ED-P; 28%) exhibits higher influence of emotions on eating behavior, less avoidance of unhealthy foods, and increased consumption of sweets, pastries, and alcohol. The odds of changing eating behavior either to HO-P or ED-P were higher in women, people with migration background, younger participants, and increased with BMI categories.\r\n \r\n \ Conclusion\r\n Both, the ED-P and HO-P, exhibit distinctive reactions in eating habits and food intake when dealing with a distressing experience. In subgroups, these may lead to disturbances in eating behavior and increase the risk for eating disorders and obesity.\r\n \ " author: - first_name: Judith full_name: Bühlmeier, Judith id: '89838' last_name: Bühlmeier - first_name: Stefanie full_name: Frölich, Stefanie last_name: Frölich - first_name: Christine full_name: Ludwig, Christine last_name: Ludwig - first_name: Nadja full_name: Knoll-Pientka, Nadja last_name: Knoll-Pientka - first_name: Börge full_name: Schmidt, Börge last_name: Schmidt - first_name: Manuel full_name: Föcker, Manuel last_name: Föcker - first_name: Lars full_name: Libuda, Lars id: '88682' last_name: Libuda orcid: 0000-0003-1603-3133 citation: ama: 'Bühlmeier J, Frölich S, Ludwig C, et al. Changes in patterns of eating habits and food intake during the first German COVID-19 lockdown: results of a cross-sectional online survey. European Journal of Nutrition. Published online 2022. doi:10.1007/s00394-022-02919-7' apa: 'Bühlmeier, J., Frölich, S., Ludwig, C., Knoll-Pientka, N., Schmidt, B., Föcker, M., & Libuda, L. (2022). Changes in patterns of eating habits and food intake during the first German COVID-19 lockdown: results of a cross-sectional online survey. European Journal of Nutrition. https://doi.org/10.1007/s00394-022-02919-7' bibtex: '@article{Bühlmeier_Frölich_Ludwig_Knoll-Pientka_Schmidt_Föcker_Libuda_2022, title={Changes in patterns of eating habits and food intake during the first German COVID-19 lockdown: results of a cross-sectional online survey}, DOI={10.1007/s00394-022-02919-7}, journal={European Journal of Nutrition}, publisher={Springer Science and Business Media LLC}, author={Bühlmeier, Judith and Frölich, Stefanie and Ludwig, Christine and Knoll-Pientka, Nadja and Schmidt, Börge and Föcker, Manuel and Libuda, Lars}, year={2022} }' chicago: 'Bühlmeier, Judith, Stefanie Frölich, Christine Ludwig, Nadja Knoll-Pientka, Börge Schmidt, Manuel Föcker, and Lars Libuda. “Changes in Patterns of Eating Habits and Food Intake during the First German COVID-19 Lockdown: Results of a Cross-Sectional Online Survey.” European Journal of Nutrition, 2022. https://doi.org/10.1007/s00394-022-02919-7.' ieee: 'J. Bühlmeier et al., “Changes in patterns of eating habits and food intake during the first German COVID-19 lockdown: results of a cross-sectional online survey,” European Journal of Nutrition, 2022, doi: 10.1007/s00394-022-02919-7.' mla: 'Bühlmeier, Judith, et al. “Changes in Patterns of Eating Habits and Food Intake during the First German COVID-19 Lockdown: Results of a Cross-Sectional Online Survey.” European Journal of Nutrition, Springer Science and Business Media LLC, 2022, doi:10.1007/s00394-022-02919-7.' short: J. Bühlmeier, S. Frölich, C. Ludwig, N. Knoll-Pientka, B. Schmidt, M. Föcker, L. Libuda, European Journal of Nutrition (2022). date_created: 2022-07-06T15:15:01Z date_updated: 2022-10-26T15:48:54Z department: - _id: '35' doi: 10.1007/s00394-022-02919-7 keyword: - Nutrition and Dietetics - Medicine (miscellaneous) language: - iso: eng publication: European Journal of Nutrition publication_identifier: issn: - 1436-6207 - 1436-6215 publication_status: published publisher: Springer Science and Business Media LLC status: public title: 'Changes in patterns of eating habits and food intake during the first German COVID-19 lockdown: results of a cross-sectional online survey' type: journal_article user_id: '88682' year: '2022' ... --- _id: '33385' abstract: - lang: eng text: "Abstract\r\n Background\r\n \ In Sub-Saharan African countries, rapid urbanization and increasing socio-economic status are associated with a transition to decreased physical activity (PA). A more sedentary lifestyle is linked to increased body fat leading to increments in leptin levels. Since rodent and human studies in high-income countries have shown that starvation-induced hypoleptinemia triggers high PA, efforts are warranted to pursue the hypothesis that low leptin levels in lean children of low- and middle-income countries (LMIC) are also associated with high PA.\r\n \r\n Methods\r\n \ In this cross-sectional study, we assessed seven-day PA with triaxial accelerometry (ActiGraph GT3X) among 223 primary school children (9 to 12 years of age) in rural Tanzania. Moderate-to-vigorous PA (MVPA) and total accelerometer counts per day were outcome variables. Leptin was determined using enzyme linked immunosorbent assay tests from dried blood spots. Anthropometric assessments were conducted and food insecurity and socio-demographic data were gathered using semi-structured interviews.\r\n \r\n \ Results\r\n In this sample of school children in rural Tanzania, leptin concentrations (median: 0.91 ng/mL, P25: 0.55, P75: 1.69), body mass index z-scores (median: -1.35, P25: -1.93, P75: -0.82), and height-for-age-z-scores (median: -1.16, P25: -1.96, P75: -0.61) were low. In contrast, PA levels were high with a median MVPA time of 119 min/day. Linear regression confirmed that leptin levels were negatively associated with MVPA (beta: -18.1; 95%CI: -29.7; -6.5; p = 0.002) and total accelerometer counts (beta: -90,256; 95%CI: -154,146; -26,365; p = 0.006). Children residing in areas with better infrastructure had lower MVPA levels (p < 0.001) and tended to have higher leptin levels (p = 0.062) than children residing in areas only reachable via dirt roads.\r\n \r\n \ Conclusion\r\n Our cross-sectional field study is the first that supports the hypothesis of low leptin levels as a potential endocrine trigger of high PA in lean children of a LMIC. We observed early signs of a PA transition towards a less active lifestyle in a subgroup residing in areas with better infrastructure that concomitantly tended to have higher leptin concentrations. Considering that area-dependent PA differences were more pronounced among girls than boys, whereas differences in leptin levels were less pronounced, not only biological, but also external factors explain PA transition.\r\n " article_number: '933' author: - first_name: Christine full_name: Ludwig, Christine last_name: Ludwig - first_name: Nadja full_name: Knoll-Pientka, Nadja last_name: Knoll-Pientka - first_name: Akwilina full_name: Mwanri, Akwilina last_name: Mwanri - first_name: Celina full_name: Erfle, Celina last_name: Erfle - first_name: Vincent full_name: Onywera, Vincent last_name: Onywera - first_name: Mark S. full_name: Tremblay, Mark S. last_name: Tremblay - first_name: Judith full_name: Bühlmeier, Judith id: '89838' last_name: Bühlmeier - first_name: Agnes full_name: Luzak, Agnes last_name: Luzak - first_name: Maike full_name: Ferland, Maike last_name: Ferland - first_name: Holger full_name: Schulz, Holger last_name: Schulz - first_name: Lars full_name: Libuda, Lars id: '88682' last_name: Libuda orcid: 0000-0003-1603-3133 - first_name: Johannes full_name: Hebebrand, Johannes last_name: Hebebrand citation: ama: Ludwig C, Knoll-Pientka N, Mwanri A, et al. Low leptin levels are associated with elevated physical activity among lean school children in rural Tanzania. BMC Public Health. 2022;22(1). doi:10.1186/s12889-022-12949-9 apa: Ludwig, C., Knoll-Pientka, N., Mwanri, A., Erfle, C., Onywera, V., Tremblay, M. S., Bühlmeier, J., Luzak, A., Ferland, M., Schulz, H., Libuda, L., & Hebebrand, J. (2022). Low leptin levels are associated with elevated physical activity among lean school children in rural Tanzania. BMC Public Health, 22(1), Article 933. https://doi.org/10.1186/s12889-022-12949-9 bibtex: '@article{Ludwig_Knoll-Pientka_Mwanri_Erfle_Onywera_Tremblay_Bühlmeier_Luzak_Ferland_Schulz_et al._2022, title={Low leptin levels are associated with elevated physical activity among lean school children in rural Tanzania}, volume={22}, DOI={10.1186/s12889-022-12949-9}, number={1933}, journal={BMC Public Health}, publisher={Springer Science and Business Media LLC}, author={Ludwig, Christine and Knoll-Pientka, Nadja and Mwanri, Akwilina and Erfle, Celina and Onywera, Vincent and Tremblay, Mark S. and Bühlmeier, Judith and Luzak, Agnes and Ferland, Maike and Schulz, Holger and et al.}, year={2022} }' chicago: Ludwig, Christine, Nadja Knoll-Pientka, Akwilina Mwanri, Celina Erfle, Vincent Onywera, Mark S. Tremblay, Judith Bühlmeier, et al. “Low Leptin Levels Are Associated with Elevated Physical Activity among Lean School Children in Rural Tanzania.” BMC Public Health 22, no. 1 (2022). https://doi.org/10.1186/s12889-022-12949-9. ieee: 'C. Ludwig et al., “Low leptin levels are associated with elevated physical activity among lean school children in rural Tanzania,” BMC Public Health, vol. 22, no. 1, Art. no. 933, 2022, doi: 10.1186/s12889-022-12949-9.' mla: Ludwig, Christine, et al. “Low Leptin Levels Are Associated with Elevated Physical Activity among Lean School Children in Rural Tanzania.” BMC Public Health, vol. 22, no. 1, 933, Springer Science and Business Media LLC, 2022, doi:10.1186/s12889-022-12949-9. short: C. Ludwig, N. Knoll-Pientka, A. Mwanri, C. Erfle, V. Onywera, M.S. Tremblay, J. Bühlmeier, A. Luzak, M. Ferland, H. Schulz, L. Libuda, J. Hebebrand, BMC Public Health 22 (2022). date_created: 2022-09-15T09:21:56Z date_updated: 2022-10-27T08:37:03Z department: - _id: '35' - _id: '17' doi: 10.1186/s12889-022-12949-9 extern: '1' intvolume: ' 22' issue: '1' keyword: - Public Health - Environmental and Occupational Health language: - iso: eng publication: BMC Public Health publication_identifier: issn: - 1471-2458 publication_status: published publisher: Springer Science and Business Media LLC status: public title: Low leptin levels are associated with elevated physical activity among lean school children in rural Tanzania type: journal_article user_id: '14931' volume: 22 year: '2022' ... --- _id: '33386' abstract: - lang: eng text: "Abstract\r\n Background/objectives\r\n \ The transition to adolescence is characterised by considerable behavioural changes, including diet. This study describes the level of obesogenic eating behaviours in 10- and 15-year-olds, and their association with dietary intake.\r\n \r\n Subjects/methods\r\n \ Participants of the 10- and 15-year follow-ups of the German GINIplus and LISA birth cohort studies were included (N10 = 2257; N15 = 1880). Eating behaviours and dietary intake were assessed via self-report questionnaires. Sex-stratified, cross-sectional associations of “external eating”, “emotional eating” and “dietary restraint” (the latter at age 15 years only) with dietary intake (17 food groups—categorised into tertiles, macronutrients, and total energy) were assessed using multinomial logistic or multiple linear regression as required, adjusting for covariates and correcting for multiple testing.\r\n \r\n Results\r\n \ Reported levels of eating behaviours were low in both age-groups. External eating was higher in 10-year-old males than females, while all eating behaviours were most pronounced in 15-year-old females. At 10 years, emotional eating was associated with medium vegetable intake in females (Relative Risk Ratio (RRR) = 1.84, p = 0.0017). At 15 years, external eating was associated with total energy (kJ) in females (β = 718, p = 0.0002) and high butter intake in males (RRR = 1.96, p = 0.0019). Dietary restraint in females was inversely associated with total energy (β = −967, p < 0.0001) and omega-3 fatty acids (Means Ratio (MR) = 0.94, p = 0.0017), and positively associated with high fruit (RRR = 2.20, p = 0.0003) and whole grains (RRR = 1.94, p = 0.0013).\r\n \ \r\n Conclusion\r\n \ Obesogenic eating behaviour scores are low among children and adolescents of a predominantly high socioeconomic status population and present only few associations with specific aspects of diet, mainly among adolescent females.\r\n \ " author: - first_name: Anne full_name: Marb, Anne last_name: Marb - first_name: Lars full_name: Libuda, Lars id: '88682' last_name: Libuda orcid: 0000-0003-1603-3133 - first_name: Marie full_name: Standl, Marie last_name: Standl - first_name: Sibylle full_name: Koletzko, Sibylle last_name: Koletzko - first_name: Carl-Peter full_name: Bauer, Carl-Peter last_name: Bauer - first_name: Tamara full_name: Schikowski, Tamara last_name: Schikowski - first_name: Dietrich full_name: Berdel, Dietrich last_name: Berdel - first_name: Andrea full_name: von Berg, Andrea last_name: von Berg - first_name: Gunda full_name: Herberth, Gunda last_name: Herberth - first_name: Judith full_name: Bühlmeier, Judith id: '89838' last_name: Bühlmeier - first_name: Carla P. full_name: Harris, Carla P. last_name: Harris citation: ama: 'Marb A, Libuda L, Standl M, et al. Obesogenic eating behaviour and dietary intake in German children and adolescents: results from the GINIplus and LISA birth cohort studies. European Journal of Clinical Nutrition. Published online 2022. doi:10.1038/s41430-022-01125-2' apa: 'Marb, A., Libuda, L., Standl, M., Koletzko, S., Bauer, C.-P., Schikowski, T., Berdel, D., von Berg, A., Herberth, G., Bühlmeier, J., & Harris, C. P. (2022). Obesogenic eating behaviour and dietary intake in German children and adolescents: results from the GINIplus and LISA birth cohort studies. European Journal of Clinical Nutrition. https://doi.org/10.1038/s41430-022-01125-2' bibtex: '@article{Marb_Libuda_Standl_Koletzko_Bauer_Schikowski_Berdel_von Berg_Herberth_Bühlmeier_et al._2022, title={Obesogenic eating behaviour and dietary intake in German children and adolescents: results from the GINIplus and LISA birth cohort studies}, DOI={10.1038/s41430-022-01125-2}, journal={European Journal of Clinical Nutrition}, publisher={Springer Science and Business Media LLC}, author={Marb, Anne and Libuda, Lars and Standl, Marie and Koletzko, Sibylle and Bauer, Carl-Peter and Schikowski, Tamara and Berdel, Dietrich and von Berg, Andrea and Herberth, Gunda and Bühlmeier, Judith and et al.}, year={2022} }' chicago: 'Marb, Anne, Lars Libuda, Marie Standl, Sibylle Koletzko, Carl-Peter Bauer, Tamara Schikowski, Dietrich Berdel, et al. “Obesogenic Eating Behaviour and Dietary Intake in German Children and Adolescents: Results from the GINIplus and LISA Birth Cohort Studies.” European Journal of Clinical Nutrition, 2022. https://doi.org/10.1038/s41430-022-01125-2.' ieee: 'A. Marb et al., “Obesogenic eating behaviour and dietary intake in German children and adolescents: results from the GINIplus and LISA birth cohort studies,” European Journal of Clinical Nutrition, 2022, doi: 10.1038/s41430-022-01125-2.' mla: 'Marb, Anne, et al. “Obesogenic Eating Behaviour and Dietary Intake in German Children and Adolescents: Results from the GINIplus and LISA Birth Cohort Studies.” European Journal of Clinical Nutrition, Springer Science and Business Media LLC, 2022, doi:10.1038/s41430-022-01125-2.' short: A. Marb, L. Libuda, M. Standl, S. Koletzko, C.-P. Bauer, T. Schikowski, D. Berdel, A. von Berg, G. Herberth, J. Bühlmeier, C.P. Harris, European Journal of Clinical Nutrition (2022). date_created: 2022-09-15T09:25:50Z date_updated: 2022-10-27T08:34:52Z department: - _id: '17' - _id: '36' doi: 10.1038/s41430-022-01125-2 extern: '1' keyword: - Nutrition and Dietetics - Medicine (miscellaneous) language: - iso: eng publication: European Journal of Clinical Nutrition publication_identifier: issn: - 0954-3007 - 1476-5640 publication_status: published publisher: Springer Science and Business Media LLC status: public title: 'Obesogenic eating behaviour and dietary intake in German children and adolescents: results from the GINIplus and LISA birth cohort studies' type: journal_article user_id: '14931' year: '2022' ... --- _id: '32327' abstract: - lang: eng text: 'AbstractThere is preliminary evidence that adrenal steroids other than cortisol may be valuable biomarkers for major depressive disorder (MDD). So far, studies have been conducted in adults only, and conclusions are limited, mainly due to small sample sizes. Therefore, the present study assessed whether adrenal steroids serve as biomarkers for adolescent MDD. In 261 depressed adolescents (170 females) treated at a single psychiatric hospital, serum adrenal steroids (progesterone, 17-hydroxyprogesterone, 21-deoxycortisol, 11-deoxycortisol, cortisol, cortisone, deoxycorticosterone, corticosterone) were determined by liquid chromatography-tandem mass spectrometry. Findings were compared to that of an age- and sex-matched reference cohort (N = 255) by nonparametric analysis of variance. Nonparametric receiver operating characteristics (ROC) analyses were conducted to evaluate the diagnostic performance of single steroids and steroid ratios to classify depression status. Sensitivity analyses considered important confounders of adrenal functioning, and ROC results were verified by cross-validation. Compared to the reference cohort, levels of deoxycorticosterone and 21-deoxycortisol were decreased (P < 0.001). All other glucocorticoid- and mineralocorticoid-related steroids were increased (P < 0.001). The corticosterone to deoxycorticosterone ratio evidenced excellent classification characteristics, especially in females (AUC: 0.957; sensitivity: 0.902; specificity: 0.891). The adrenal steroid metabolome qualifies as a bio-readout reflecting adolescent MDD by a distinct steroid pattern that indicates dysfunction of the hypothalamus–pituitary–adrenal axis. Moreover, the corticosterone to deoxycorticosterone ratio may prospectively qualify to contribute to precision medicine in psychiatry by identifying those patients who might benefit from antiglucocorticoid treatment or those at risk for recurrence when adrenal dysfunction has not resolved.' article_number: '255' author: - first_name: Raphael full_name: Hirtz, Raphael last_name: Hirtz - first_name: Lars full_name: Libuda, Lars id: '88682' last_name: Libuda orcid: 0000-0003-1603-3133 - first_name: Anke full_name: Hinney, Anke last_name: Hinney - first_name: Manuel full_name: Föcker, Manuel last_name: Föcker - first_name: Judith full_name: Bühlmeier, Judith id: '89838' last_name: Bühlmeier - first_name: Paul-Martin full_name: Holterhus, Paul-Martin last_name: Holterhus - first_name: Alexandra full_name: Kulle, Alexandra last_name: Kulle - first_name: Cordula full_name: Kiewert, Cordula last_name: Kiewert - first_name: Berthold P. full_name: Hauffa, Berthold P. last_name: Hauffa - first_name: Johannes full_name: Hebebrand, Johannes last_name: Hebebrand - first_name: Corinna full_name: Grasemann, Corinna last_name: Grasemann citation: ama: 'Hirtz R, Libuda L, Hinney A, et al. The adrenal steroid profile in adolescent depression: a valuable bio-readout? Translational Psychiatry. 2022;12(1). doi:10.1038/s41398-022-01966-2' apa: 'Hirtz, R., Libuda, L., Hinney, A., Föcker, M., Bühlmeier, J., Holterhus, P.-M., Kulle, A., Kiewert, C., Hauffa, B. P., Hebebrand, J., & Grasemann, C. (2022). The adrenal steroid profile in adolescent depression: a valuable bio-readout? Translational Psychiatry, 12(1), Article 255. https://doi.org/10.1038/s41398-022-01966-2' bibtex: '@article{Hirtz_Libuda_Hinney_Föcker_Bühlmeier_Holterhus_Kulle_Kiewert_Hauffa_Hebebrand_et al._2022, title={The adrenal steroid profile in adolescent depression: a valuable bio-readout?}, volume={12}, DOI={10.1038/s41398-022-01966-2}, number={1255}, journal={Translational Psychiatry}, publisher={Springer Science and Business Media LLC}, author={Hirtz, Raphael and Libuda, Lars and Hinney, Anke and Föcker, Manuel and Bühlmeier, Judith and Holterhus, Paul-Martin and Kulle, Alexandra and Kiewert, Cordula and Hauffa, Berthold P. and Hebebrand, Johannes and et al.}, year={2022} }' chicago: 'Hirtz, Raphael, Lars Libuda, Anke Hinney, Manuel Föcker, Judith Bühlmeier, Paul-Martin Holterhus, Alexandra Kulle, et al. “The Adrenal Steroid Profile in Adolescent Depression: A Valuable Bio-Readout?” Translational Psychiatry 12, no. 1 (2022). https://doi.org/10.1038/s41398-022-01966-2.' ieee: 'R. Hirtz et al., “The adrenal steroid profile in adolescent depression: a valuable bio-readout?,” Translational Psychiatry, vol. 12, no. 1, Art. no. 255, 2022, doi: 10.1038/s41398-022-01966-2.' mla: 'Hirtz, Raphael, et al. “The Adrenal Steroid Profile in Adolescent Depression: A Valuable Bio-Readout?” Translational Psychiatry, vol. 12, no. 1, 255, Springer Science and Business Media LLC, 2022, doi:10.1038/s41398-022-01966-2.' short: R. Hirtz, L. Libuda, A. Hinney, M. Föcker, J. Bühlmeier, P.-M. Holterhus, A. Kulle, C. Kiewert, B.P. Hauffa, J. Hebebrand, C. Grasemann, Translational Psychiatry 12 (2022). date_created: 2022-07-06T15:14:39Z date_updated: 2023-01-06T11:48:51Z department: - _id: '35' doi: 10.1038/s41398-022-01966-2 intvolume: ' 12' issue: '1' keyword: - Biological Psychiatry - Cellular and Molecular Neuroscience - Psychiatry and Mental health language: - iso: eng publication: Translational Psychiatry publication_identifier: issn: - 2158-3188 publication_status: published publisher: Springer Science and Business Media LLC status: public title: 'The adrenal steroid profile in adolescent depression: a valuable bio-readout?' type: journal_article user_id: '88682' volume: 12 year: '2022' ... --- _id: '27571' abstract: - lang: eng text: '(1) Background: Evidence has accumulated that patients with anorexia nervosa (AN) are at higher risk for vitamin D deficiency than healthy controls. In epidemiologic studies, low 25(OH) vitamin D (25(OH)D) levels were associated with depression. This study analyzed the relationship between 25(OH)D serum levels in adolescent patients and AN and depressive symptoms over the course of treatment. (2) Methods: 25(OH)D levels and depressive symptoms were analyzed in 93 adolescent (in-)patients with AN from the Anorexia Nervosa Day patient versus Inpatient (ANDI) multicenter trial at clinic admission, discharge, and 1 year follow up. Mixed regression models were used to analyze the relationship between 25(OH)D levels and depressive symptoms assessed by the Beck Depression Inventory (BDI-II). (3) Results: Although mean 25(OH)D levels constantly remained in recommended ranges (≥50 nmol/L) during AN treatment, levels decreased from (in)patient admission to 1 year follow up. Levels of 25(OH)D were neither cross-sectionally, prospectively, nor longitudinally associated with the BDI-II score. (4) Conclusions: This study did not confirm that 25(OH)D levels are associated with depressive symptoms in patients with AN. However, increasing risks of vitamin D deficiency over the course of AN treatment indicate that clinicians should monitor 25(OH)D levels.' article_number: '2356' author: - first_name: Manuel full_name: Föcker, Manuel last_name: Föcker - first_name: Nina full_name: Timmesfeld, Nina last_name: Timmesfeld - first_name: Judith full_name: Bühlmeier, Judith id: '89838' last_name: Bühlmeier - first_name: Denise full_name: Zwanziger, Denise last_name: Zwanziger - first_name: Dagmar full_name: Führer, Dagmar last_name: Führer - first_name: Corinna full_name: Grasemann, Corinna last_name: Grasemann - first_name: Stefan full_name: Ehrlich, Stefan last_name: Ehrlich - first_name: Karin full_name: Egberts, Karin last_name: Egberts - first_name: Christian full_name: Fleischhaker, Christian last_name: Fleischhaker - first_name: Christoph full_name: Wewetzer, Christoph last_name: Wewetzer - first_name: Ida full_name: Wessing, Ida last_name: Wessing - first_name: Jochen full_name: Seitz, Jochen last_name: Seitz - first_name: Beate full_name: Herpertz-Dahlmann, Beate last_name: Herpertz-Dahlmann - first_name: Johannes full_name: Hebebrand, Johannes last_name: Hebebrand - first_name: Lars full_name: Libuda, Lars id: '88682' last_name: Libuda orcid: 0000-0003-1603-3133 citation: ama: 'Föcker M, Timmesfeld N, Bühlmeier J, et al. Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms. Nutrients. Published online 2021. doi:10.3390/nu13072356' apa: 'Föcker, M., Timmesfeld, N., Bühlmeier, J., Zwanziger, D., Führer, D., Grasemann, C., Ehrlich, S., Egberts, K., Fleischhaker, C., Wewetzer, C., Wessing, I., Seitz, J., Herpertz-Dahlmann, B., Hebebrand, J., & Libuda, L. (2021). Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms. Nutrients, Article 2356. https://doi.org/10.3390/nu13072356' bibtex: '@article{Föcker_Timmesfeld_Bühlmeier_Zwanziger_Führer_Grasemann_Ehrlich_Egberts_Fleischhaker_Wewetzer_et al._2021, title={Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms}, DOI={10.3390/nu13072356}, number={2356}, journal={Nutrients}, author={Föcker, Manuel and Timmesfeld, Nina and Bühlmeier, Judith and Zwanziger, Denise and Führer, Dagmar and Grasemann, Corinna and Ehrlich, Stefan and Egberts, Karin and Fleischhaker, Christian and Wewetzer, Christoph and et al.}, year={2021} }' chicago: 'Föcker, Manuel, Nina Timmesfeld, Judith Bühlmeier, Denise Zwanziger, Dagmar Führer, Corinna Grasemann, Stefan Ehrlich, et al. “Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms.” Nutrients, 2021. https://doi.org/10.3390/nu13072356.' ieee: 'M. Föcker et al., “Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms,” Nutrients, Art. no. 2356, 2021, doi: 10.3390/nu13072356.' mla: 'Föcker, Manuel, et al. “Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms.” Nutrients, 2356, 2021, doi:10.3390/nu13072356.' short: M. Föcker, N. Timmesfeld, J. Bühlmeier, D. Zwanziger, D. Führer, C. Grasemann, S. Ehrlich, K. Egberts, C. Fleischhaker, C. Wewetzer, I. Wessing, J. Seitz, B. Herpertz-Dahlmann, J. Hebebrand, L. Libuda, Nutrients (2021). date_created: 2021-11-18T19:23:23Z date_updated: 2022-09-15T09:42:11Z department: - _id: '35' - _id: '22' - _id: '395' doi: 10.3390/nu13072356 extern: '1' language: - iso: eng publication: Nutrients publication_identifier: issn: - 2072-6643 publication_status: published status: public title: 'Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms' type: journal_article user_id: '89838' year: '2021' ... --- _id: '26632' abstract: - lang: eng text: AbstractAnorexia nervosa (AN) is a severe eating disorder and often associated with altered humoral immune responses. However, distinct B cell maturation stages in peripheral blood in adolescents with AN have not been characterized. Treatment effects and the relationship between clinical and B cell parameters are also not fully understood. Here we investigated the phenotype of circulating B cell subsets and the relationship with body composition in adolescents with AN before (T0, n = 24) and after 6 weeks (T1, n = 20) of treatment. Using multi-parameter flow cytometry, we found increased percentages of antigen-experienced B cells and plasmablasts in patients with AN compared to healthy controls (n = 20). In contrast, percentages of CD1d+CD5+ B cells and transitional B cells with immunoregulatory roles were reduced at T0 and T1. These B cell frequencies correlated positively with fat mass, fat mass index (FMI), free fat mass index, and body mass index standard deviation score. In addition, scavenger-like receptor CD5 expression levels were downregulated on transitional B cells and correlated with fat mass and FMI in AN. Our findings that regulatory B cell subgroups were reduced in AN and their strong relationship with body composition parameters point toward an impact of immunoregulatory B cells in the pathogenesis of AN. author: - first_name: Jana full_name: Freff, Jana last_name: Freff - first_name: Kathrin full_name: Schwarte, Kathrin last_name: Schwarte - first_name: Lisa full_name: Bröker, Lisa last_name: Bröker - first_name: Judith full_name: Bühlmeier, Judith id: '89838' last_name: Bühlmeier - first_name: Isabelle full_name: Kraft, Isabelle last_name: Kraft - first_name: Dana full_name: Öztürk, Dana last_name: Öztürk - first_name: Anke full_name: Hinney, Anke last_name: Hinney - first_name: Volker full_name: Arolt, Volker last_name: Arolt - first_name: Udo full_name: Dannlowski, Udo last_name: Dannlowski - first_name: Georg full_name: Romer, Georg last_name: Romer - first_name: Bernhard T. full_name: Baune, Bernhard T. last_name: Baune - first_name: Johannes full_name: Hebebrand, Johannes last_name: Hebebrand - first_name: Manuel full_name: Föcker, Manuel last_name: Föcker - first_name: Judith full_name: Alferink, Judith last_name: Alferink citation: ama: Freff J, Schwarte K, Bröker L, et al. Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa. Scientific Reports. Published online 2021. doi:10.1038/s41598-020-80693-4 apa: Freff, J., Schwarte, K., Bröker, L., Bühlmeier, J., Kraft, I., Öztürk, D., Hinney, A., Arolt, V., Dannlowski, U., Romer, G., Baune, B. T., Hebebrand, J., Föcker, M., & Alferink, J. (2021). Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa. Scientific Reports. https://doi.org/10.1038/s41598-020-80693-4 bibtex: '@article{Freff_Schwarte_Bröker_Bühlmeier_Kraft_Öztürk_Hinney_Arolt_Dannlowski_Romer_et al._2021, title={Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa}, DOI={10.1038/s41598-020-80693-4}, journal={Scientific Reports}, author={Freff, Jana and Schwarte, Kathrin and Bröker, Lisa and Bühlmeier, Judith and Kraft, Isabelle and Öztürk, Dana and Hinney, Anke and Arolt, Volker and Dannlowski, Udo and Romer, Georg and et al.}, year={2021} }' chicago: Freff, Jana, Kathrin Schwarte, Lisa Bröker, Judith Bühlmeier, Isabelle Kraft, Dana Öztürk, Anke Hinney, et al. “Alterations in B Cell Subsets Correlate with Body Composition Parameters in Female Adolescents with Anorexia Nervosa.” Scientific Reports, 2021. https://doi.org/10.1038/s41598-020-80693-4. ieee: 'J. Freff et al., “Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa,” Scientific Reports, 2021, doi: 10.1038/s41598-020-80693-4.' mla: Freff, Jana, et al. “Alterations in B Cell Subsets Correlate with Body Composition Parameters in Female Adolescents with Anorexia Nervosa.” Scientific Reports, 2021, doi:10.1038/s41598-020-80693-4. short: J. Freff, K. Schwarte, L. Bröker, J. Bühlmeier, I. Kraft, D. Öztürk, A. Hinney, V. Arolt, U. Dannlowski, G. Romer, B.T. Baune, J. Hebebrand, M. Föcker, J. Alferink, Scientific Reports (2021). date_created: 2021-10-20T18:56:17Z date_updated: 2022-09-15T09:50:35Z department: - _id: '35' - _id: '22' - _id: '395' doi: 10.1038/s41598-020-80693-4 extern: '1' language: - iso: eng publication: Scientific Reports publication_identifier: issn: - 2045-2322 publication_status: published status: public title: Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa type: journal_article user_id: '89838' year: '2021' ... --- _id: '26525' author: - first_name: Johannes full_name: Hebebrand, Johannes last_name: Hebebrand - first_name: Jochen full_name: Antel, Jochen last_name: Antel - first_name: Susanne full_name: Tan, Susanne last_name: Tan - first_name: Martin full_name: Wabitsch, Martin last_name: Wabitsch - first_name: Urban full_name: Wiesing, Urban last_name: Wiesing - first_name: Nikolaus full_name: Barth, Nikolaus last_name: Barth - first_name: Christine full_name: Ludwig, Christine last_name: Ludwig - first_name: Judith full_name: Bühlmeier, Judith id: '89838' last_name: Bühlmeier - first_name: Lars full_name: Libuda, Lars id: '88682' last_name: Libuda orcid: 0000-0003-1603-3133 - first_name: Gabriella full_name: Milos, Gabriella last_name: Milos - first_name: Anke full_name: Hinney, Anke last_name: Hinney citation: ama: 'Hebebrand J, Antel J, Tan S, et al. Kurzzeitige Behandlung von Patient_innen mit Anorexia nervosa mit                    rekombinant hergestelltem Human-Leptin (Metreleptin): Rasch einsetzende positive                    Effekte auf Stimmung, Kognition und Verhalten. Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie. Published online 2021:1-5. doi:10.1024/1422-4917/a000775' apa: 'Hebebrand, J., Antel, J., Tan, S., Wabitsch, M., Wiesing, U., Barth, N., Ludwig, C., Bühlmeier, J., Libuda, L., Milos, G., & Hinney, A. (2021). Kurzzeitige Behandlung von Patient_innen mit Anorexia nervosa mit                    rekombinant hergestelltem Human-Leptin (Metreleptin): Rasch einsetzende positive                    Effekte auf Stimmung, Kognition und Verhalten. Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, 1–5. https://doi.org/10.1024/1422-4917/a000775' bibtex: '@article{Hebebrand_Antel_Tan_Wabitsch_Wiesing_Barth_Ludwig_Bühlmeier_Libuda_Milos_et al._2021, title={Kurzzeitige Behandlung von Patient_innen mit Anorexia nervosa mit                    rekombinant hergestelltem Human-Leptin (Metreleptin): Rasch einsetzende positive                    Effekte auf Stimmung, Kognition und Verhalten}, DOI={10.1024/1422-4917/a000775}, journal={Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie}, author={Hebebrand, Johannes and Antel, Jochen and Tan, Susanne and Wabitsch, Martin and Wiesing, Urban and Barth, Nikolaus and Ludwig, Christine and Bühlmeier, Judith and Libuda, Lars and Milos, Gabriella and et al.}, year={2021}, pages={1–5} }' chicago: 'Hebebrand, Johannes, Jochen Antel, Susanne Tan, Martin Wabitsch, Urban Wiesing, Nikolaus Barth, Christine Ludwig, et al. “Kurzzeitige Behandlung von Patient_innen mit Anorexia nervosa mit                    rekombinant hergestelltem Human-Leptin (Metreleptin): Rasch einsetzende positive                    Effekte auf Stimmung, Kognition und Verhalten.” Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, 2021, 1–5. https://doi.org/10.1024/1422-4917/a000775.' ieee: 'J. Hebebrand et al., “Kurzzeitige Behandlung von Patient_innen mit Anorexia nervosa mit                    rekombinant hergestelltem Human-Leptin (Metreleptin): Rasch einsetzende positive                    Effekte auf Stimmung, Kognition und Verhalten,” Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, pp. 1–5, 2021, doi: 10.1024/1422-4917/a000775.' mla: 'Hebebrand, Johannes, et al. “Kurzzeitige Behandlung von Patient_innen mit Anorexia nervosa mit                    rekombinant hergestelltem Human-Leptin (Metreleptin): Rasch einsetzende positive                    Effekte auf Stimmung, Kognition und Verhalten.” Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, 2021, pp. 1–5, doi:10.1024/1422-4917/a000775.' short: J. Hebebrand, J. Antel, S. Tan, M. Wabitsch, U. Wiesing, N. Barth, C. Ludwig, J. Bühlmeier, L. Libuda, G. Milos, A. Hinney, Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie (2021) 1–5. date_created: 2021-10-19T09:55:10Z date_updated: 2022-09-15T09:50:49Z department: - _id: '35' - _id: '22' doi: 10.1024/1422-4917/a000775 extern: '1' language: - iso: ger page: 1-5 publication: Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie publication_identifier: issn: - 1422-4917 - 1664-2880 publication_status: published status: public title: 'Kurzzeitige Behandlung von Patient_innen mit Anorexia nervosa mit rekombinant hergestelltem Human-Leptin (Metreleptin): Rasch einsetzende positive Effekte auf Stimmung, Kognition und Verhalten' type: journal_article user_id: '89838' year: '2021' ... --- _id: '27022' abstract: - lang: eng text: "Abstract\r\nPurpose\r\nWhile observational studies revealed inverse associations between serum vitamin D levels [25(OH)D] and depression, randomized controlled trials (RCT) in children and adolescents are lacking. This RCT examined the effect of an untreated vitamin D deficiency compared to an immediate vitamin D3 supplementation on depression scores in children and adolescents during standard day and in-patient psychiatric treatment.\r\n\r\nMethods\r\nPatients with vitamin D deficiency [25(OH)D ≤ 30 nmol/l] and at least mild depression [Beck Depression Inventory II (BDI-II) > 13] (n = 113) were 1:1 randomized into verum (VG; 2640 IU vitamin D3/d) or placebo group (PG) in a double-blind manner. During the intervention period of 28 days, both groups additionally received treatment as usual. BDI-II scores were assessed as primary outcome, DISYPS-II (Diagnostic System for Mental Disorders in Childhood and Adolescence, Self- and Parent Rating) and serum total 25(OH)D were secondary outcomes.\r\n\r\nResults\r\nAt admission, 49.3% of the screened patients (n = 280) had vitamin D deficiency. Although the intervention led to a higher increase of 25(OH)D levels in the VG than in the PG (treatment difference: + 14 ng/ml; 95% CI 4.86–23.77; p = 0.003), the change in BDI-II scores did not differ (+ 1.3; 95% CI − 2.22 to 4.81; p = 0.466). In contrast, DISYPS parental ratings revealed pronounced improvements of depressive symptoms in the VG (− 0.68; 95% CI − 1.23 to − 0.13; p = 0.016).\r\n\r\nConclusion\r\nWhereas this study failed to show a vitamin D supplementation effect on self-rated depression in adolescent in- or daycare patients, parents reported less depressive symptoms in VG at the end of our study. Future trials should consider clinician-rated depressive symptoms as primary outcome.\r\n\r\nTrial registration\r\n“German Clinical Trials Register” (https://www.drks.de), registration number: DRKS00009758\r\n" author: - first_name: Lars full_name: Libuda, Lars id: '88682' last_name: Libuda orcid: 0000-0003-1603-3133 - first_name: Nina full_name: Timmesfeld, Nina last_name: Timmesfeld - first_name: Jochen full_name: Antel, Jochen last_name: Antel - first_name: Raphael full_name: Hirtz, Raphael last_name: Hirtz - first_name: Jens full_name: Bauer, Jens last_name: Bauer - first_name: Dagmar full_name: Führer, Dagmar last_name: Führer - first_name: Denise full_name: Zwanziger, Denise last_name: Zwanziger - first_name: Dana full_name: Öztürk, Dana last_name: Öztürk - first_name: Gina full_name: Langenbach, Gina last_name: Langenbach - first_name: Denise full_name: Hahn, Denise last_name: Hahn - first_name: Stefanie full_name: Ring, Stefanie last_name: Ring - first_name: Triinu full_name: Peters, Triinu last_name: Peters - first_name: Anke full_name: Hinney, Anke last_name: Hinney - first_name: Judith full_name: Bühlmeier, Judith id: '89838' last_name: Bühlmeier - first_name: Johannes full_name: Hebebrand, Johannes last_name: Hebebrand - first_name: Corinna full_name: Grasemann, Corinna last_name: Grasemann - first_name: Manuel full_name: Föcker, Manuel last_name: Föcker citation: ama: 'Libuda L, Timmesfeld N, Antel J, et al. Effect of vitamin D deficiency on depressive symptoms in child and adolescent psychiatric patients: results of a randomized controlled trial. European Journal of Nutrition. Published online 2020:3415-3424. doi:10.1007/s00394-020-02176-6' apa: 'Libuda, L., Timmesfeld, N., Antel, J., Hirtz, R., Bauer, J., Führer, D., Zwanziger, D., Öztürk, D., Langenbach, G., Hahn, D., Ring, S., Peters, T., Hinney, A., Bühlmeier, J., Hebebrand, J., Grasemann, C., & Föcker, M. (2020). Effect of vitamin D deficiency on depressive symptoms in child and adolescent psychiatric patients: results of a randomized controlled trial. European Journal of Nutrition, 3415–3424. https://doi.org/10.1007/s00394-020-02176-6' bibtex: '@article{Libuda_Timmesfeld_Antel_Hirtz_Bauer_Führer_Zwanziger_Öztürk_Langenbach_Hahn_et al._2020, title={Effect of vitamin D deficiency on depressive symptoms in child and adolescent psychiatric patients: results of a randomized controlled trial}, DOI={10.1007/s00394-020-02176-6}, journal={European Journal of Nutrition}, author={Libuda, Lars and Timmesfeld, Nina and Antel, Jochen and Hirtz, Raphael and Bauer, Jens and Führer, Dagmar and Zwanziger, Denise and Öztürk, Dana and Langenbach, Gina and Hahn, Denise and et al.}, year={2020}, pages={3415–3424} }' chicago: 'Libuda, Lars, Nina Timmesfeld, Jochen Antel, Raphael Hirtz, Jens Bauer, Dagmar Führer, Denise Zwanziger, et al. “Effect of Vitamin D Deficiency on Depressive Symptoms in Child and Adolescent Psychiatric Patients: Results of a Randomized Controlled Trial.” European Journal of Nutrition, 2020, 3415–24. https://doi.org/10.1007/s00394-020-02176-6.' ieee: 'L. Libuda et al., “Effect of vitamin D deficiency on depressive symptoms in child and adolescent psychiatric patients: results of a randomized controlled trial,” European Journal of Nutrition, pp. 3415–3424, 2020, doi: 10.1007/s00394-020-02176-6.' mla: 'Libuda, Lars, et al. “Effect of Vitamin D Deficiency on Depressive Symptoms in Child and Adolescent Psychiatric Patients: Results of a Randomized Controlled Trial.” European Journal of Nutrition, 2020, pp. 3415–24, doi:10.1007/s00394-020-02176-6.' short: L. Libuda, N. Timmesfeld, J. Antel, R. Hirtz, J. Bauer, D. Führer, D. Zwanziger, D. Öztürk, G. Langenbach, D. Hahn, S. Ring, T. Peters, A. Hinney, J. Bühlmeier, J. Hebebrand, C. Grasemann, M. Föcker, European Journal of Nutrition (2020) 3415–3424. date_created: 2021-11-01T19:11:56Z date_updated: 2022-09-15T09:49:57Z department: - _id: '35' - _id: '22' - _id: '395' doi: 10.1007/s00394-020-02176-6 extern: '1' language: - iso: eng page: 3415-3424 publication: European Journal of Nutrition publication_identifier: issn: - 1436-6207 - 1436-6215 publication_status: published status: public title: 'Effect of vitamin D deficiency on depressive symptoms in child and adolescent psychiatric patients: results of a randomized controlled trial' type: journal_article user_id: '89838' year: '2020' ... --- _id: '33389' abstract: - lang: eng text: "Abstract\r\nPurpose\r\nSpace flight and bed rest (BR) lead to a rapid decline in exercise capacity. Whey protein plus potassium bicarbonate diet-supplementation (NUTR) could attenuate this effect by improving oxidative metabolism. We evaluated the impact of 21-day BR and NUTR on fatigue resistance of plantar flexor muscles (PF) during repeated shortening contractions, and whether any change was related to altered energy metabolism and muscle oxygenation.\r\n\r\nMethods\r\nTen healthy men received a standardized isocaloric diet with (n = 5) or without (n = 5) NUTR. Eight bouts of 24 concentric plantar flexions (30 s each bout) with 20 s rest between bouts were employed. PF muscle size was assessed by means of peripheral quantitative computed tomography. PF muscle volume was assessed with magnetic resonance imaging. PF muscle force, contraction velocity, power and surface electromyogram signals were recorded during each contraction, as well as energy metabolism (31P nuclear magnetic resonance spectroscopy) and oxygenation (near-infrared spectroscopy). Cardiopulmonary parameters were measured during an incremental cycle exercise test.\r\n\r\nResults\r\nBR caused 10–15% loss of PF volume that was partly recovered 3 days after re-ambulation, as a consequence of fluid redistribution. Unexpectedly, PF fatigue resistance was not affected by BR or NUTR. BR induced a shift in muscle metabolism toward glycolysis and some signs of impaired muscle oxygen extraction. NUTR did not attenuate the BR-induced-shift in energy metabolism.\r\n\r\nConclusions\r\nTwenty-one days’ BR did not impair PF fatigue resistance, but the shift to glycolytic metabolism and indications of impaired oxygen extraction may be early signs of developing reduced muscle fatigue resistance.\r\n" author: - first_name: Alessandra full_name: Bosutti, Alessandra last_name: Bosutti - first_name: Edwin full_name: Mulder, Edwin last_name: Mulder - first_name: Jochen full_name: Zange, Jochen last_name: Zange - first_name: Judith full_name: Bühlmeier, Judith id: '89838' last_name: Bühlmeier - first_name: Bergita full_name: Ganse, Bergita last_name: Ganse - first_name: Hans full_name: Degens, Hans last_name: Degens citation: ama: Bosutti A, Mulder E, Zange J, Bühlmeier J, Ganse B, Degens H. Effects of 21 days of bed rest and whey protein supplementation on plantar flexor muscle fatigue resistance during repeated shortening contractions. European Journal of Applied Physiology. 2020;120(5):969-983. doi:10.1007/s00421-020-04333-5 apa: Bosutti, A., Mulder, E., Zange, J., Bühlmeier, J., Ganse, B., & Degens, H. (2020). Effects of 21 days of bed rest and whey protein supplementation on plantar flexor muscle fatigue resistance during repeated shortening contractions. European Journal of Applied Physiology, 120(5), 969–983. https://doi.org/10.1007/s00421-020-04333-5 bibtex: '@article{Bosutti_Mulder_Zange_Bühlmeier_Ganse_Degens_2020, title={Effects of 21 days of bed rest and whey protein supplementation on plantar flexor muscle fatigue resistance during repeated shortening contractions}, volume={120}, DOI={10.1007/s00421-020-04333-5}, number={5}, journal={European Journal of Applied Physiology}, publisher={Springer Science and Business Media LLC}, author={Bosutti, Alessandra and Mulder, Edwin and Zange, Jochen and Bühlmeier, Judith and Ganse, Bergita and Degens, Hans}, year={2020}, pages={969–983} }' chicago: 'Bosutti, Alessandra, Edwin Mulder, Jochen Zange, Judith Bühlmeier, Bergita Ganse, and Hans Degens. “Effects of 21 Days of Bed Rest and Whey Protein Supplementation on Plantar Flexor Muscle Fatigue Resistance during Repeated Shortening Contractions.” European Journal of Applied Physiology 120, no. 5 (2020): 969–83. https://doi.org/10.1007/s00421-020-04333-5.' ieee: 'A. Bosutti, E. Mulder, J. Zange, J. Bühlmeier, B. Ganse, and H. Degens, “Effects of 21 days of bed rest and whey protein supplementation on plantar flexor muscle fatigue resistance during repeated shortening contractions,” European Journal of Applied Physiology, vol. 120, no. 5, pp. 969–983, 2020, doi: 10.1007/s00421-020-04333-5.' mla: Bosutti, Alessandra, et al. “Effects of 21 Days of Bed Rest and Whey Protein Supplementation on Plantar Flexor Muscle Fatigue Resistance during Repeated Shortening Contractions.” European Journal of Applied Physiology, vol. 120, no. 5, Springer Science and Business Media LLC, 2020, pp. 969–83, doi:10.1007/s00421-020-04333-5. short: A. Bosutti, E. Mulder, J. Zange, J. Bühlmeier, B. Ganse, H. Degens, European Journal of Applied Physiology 120 (2020) 969–983. date_created: 2022-09-15T09:30:41Z date_updated: 2022-09-15T09:48:23Z doi: 10.1007/s00421-020-04333-5 extern: '1' intvolume: ' 120' issue: '5' keyword: - Physiology (medical) - Public Health - Environmental and Occupational Health - Orthopedics and Sports Medicine - General Medicine - Public Health - Environmental and Occupational Health - Physiology language: - iso: eng page: 969-983 publication: European Journal of Applied Physiology publication_identifier: issn: - 1439-6319 - 1439-6327 publication_status: published publisher: Springer Science and Business Media LLC status: public title: Effects of 21 days of bed rest and whey protein supplementation on plantar flexor muscle fatigue resistance during repeated shortening contractions type: journal_article user_id: '89838' volume: 120 year: '2020' ... --- _id: '27018' abstract: - lang: eng text: Acute anorexia nervosa (AN) constitutes an extreme physiological state. We aimed to detect state related metabolic alterations during inpatient admission and upon short- and long-term weight regain. In addition, we tested the hypothesis that metabolite concentrations adapt to those of healthy controls (HC) after long-term weight regain. Thirty-five female adolescents with AN and 25 female HC were recruited. Based on a targeted approach 187 metabolite concentrations were detected at inpatient admission (T0), after short-term weight recovery (T1; half of target-weight) and close to target weight (T2). Pattern hunter and time course analysis were performed. The highest number of significant differences in metabolite concentrations (N = 32) were observed between HC and T1. According to the detected main pattern, metabolite concentrations at T2 became more similar to those of HC. The course of single metabolite concentrations (e.g., glutamic acid) revealed different metabolic subtypes within the study sample. Patients with AN after short-term weight regain are in a greater “metabolic imbalance” than at starvation. After long-term weight regain, patients reach a metabolite profile similar to HC. Our results might be confounded by different metabolic subtypes of patients with AN. article_number: '7' author: - first_name: Manuel full_name: Föcker, Manuel last_name: Föcker - first_name: Alexander full_name: Cecil, Alexander last_name: Cecil - first_name: Cornelia full_name: Prehn, Cornelia last_name: Prehn - first_name: Jerzy full_name: Adamski, Jerzy last_name: Adamski - first_name: Muriel full_name: Albrecht, Muriel last_name: Albrecht - first_name: Frederike full_name: Adams, Frederike last_name: Adams - first_name: Anke full_name: Hinney, Anke last_name: Hinney - first_name: Lars full_name: Libuda, Lars id: '88682' last_name: Libuda orcid: 0000-0003-1603-3133 - first_name: Judith full_name: Bühlmeier, Judith id: '89838' last_name: Bühlmeier - first_name: Johannes full_name: Hebebrand, Johannes last_name: Hebebrand - first_name: Triinu full_name: Peters, Triinu last_name: Peters - first_name: Jochen full_name: Antel, Jochen last_name: Antel citation: ama: Föcker M, Cecil A, Prehn C, et al. Evaluation of Metabolic Profiles of Patients with Anorexia Nervosa at Inpatient Admission, Short- and Long-Term Weight Regain—Descriptive and Pattern Analysis. Metabolites. Published online 2020. doi:10.3390/metabo11010007 apa: Föcker, M., Cecil, A., Prehn, C., Adamski, J., Albrecht, M., Adams, F., Hinney, A., Libuda, L., Bühlmeier, J., Hebebrand, J., Peters, T., & Antel, J. (2020). Evaluation of Metabolic Profiles of Patients with Anorexia Nervosa at Inpatient Admission, Short- and Long-Term Weight Regain—Descriptive and Pattern Analysis. Metabolites, Article 7. https://doi.org/10.3390/metabo11010007 bibtex: '@article{Föcker_Cecil_Prehn_Adamski_Albrecht_Adams_Hinney_Libuda_Bühlmeier_Hebebrand_et al._2020, title={Evaluation of Metabolic Profiles of Patients with Anorexia Nervosa at Inpatient Admission, Short- and Long-Term Weight Regain—Descriptive and Pattern Analysis}, DOI={10.3390/metabo11010007}, number={7}, journal={Metabolites}, author={Föcker, Manuel and Cecil, Alexander and Prehn, Cornelia and Adamski, Jerzy and Albrecht, Muriel and Adams, Frederike and Hinney, Anke and Libuda, Lars and Bühlmeier, Judith and Hebebrand, Johannes and et al.}, year={2020} }' chicago: Föcker, Manuel, Alexander Cecil, Cornelia Prehn, Jerzy Adamski, Muriel Albrecht, Frederike Adams, Anke Hinney, et al. “Evaluation of Metabolic Profiles of Patients with Anorexia Nervosa at Inpatient Admission, Short- and Long-Term Weight Regain—Descriptive and Pattern Analysis.” Metabolites, 2020. https://doi.org/10.3390/metabo11010007. ieee: 'M. Föcker et al., “Evaluation of Metabolic Profiles of Patients with Anorexia Nervosa at Inpatient Admission, Short- and Long-Term Weight Regain—Descriptive and Pattern Analysis,” Metabolites, Art. no. 7, 2020, doi: 10.3390/metabo11010007.' mla: Föcker, Manuel, et al. “Evaluation of Metabolic Profiles of Patients with Anorexia Nervosa at Inpatient Admission, Short- and Long-Term Weight Regain—Descriptive and Pattern Analysis.” Metabolites, 7, 2020, doi:10.3390/metabo11010007. short: M. Föcker, A. Cecil, C. Prehn, J. Adamski, M. Albrecht, F. Adams, A. Hinney, L. Libuda, J. Bühlmeier, J. Hebebrand, T. Peters, J. Antel, Metabolites (2020). date_created: 2021-11-01T18:55:25Z date_updated: 2022-09-15T09:49:18Z department: - _id: '35' - _id: '22' - _id: '395' doi: 10.3390/metabo11010007 extern: '1' language: - iso: eng publication: Metabolites publication_identifier: issn: - 2218-1989 publication_status: published status: public title: Evaluation of Metabolic Profiles of Patients with Anorexia Nervosa at Inpatient Admission, Short- and Long-Term Weight Regain—Descriptive and Pattern Analysis type: journal_article user_id: '89838' year: '2020' ... --- _id: '27026' abstract: - lang: eng text: While observational studies show an association between 25(OH)vitamin D concentrations and depressive symptoms, intervention studies, which examine the preventive effects of vitamin D supplementation on the development of depression, are lacking. To estimate the role of lowered 25(OH)vitamin D concentrations in the etiology of depressive disorders, we conducted a two-sample Mendelian randomization (MR) study on depression, i.e., “depressive symptoms” (DS, n = 161,460) and “broad depression” (BD, n = 113,769 cases and 208,811 controls). Six single nucleotide polymorphisms (SNPs), which were genome-wide significantly associated with 25(OH)vitamin D concentrations in 79,366 subjects from the SUNLIGHT genome-wide association study (GWAS), were used as an instrumental variable. None of the six SNPs was associated with DS or BD (all p > 0.05). MR analysis revealed no causal effects of 25(OH)vitamin D concentration, either on DS (inverse variance weighted (IVW); b = 0.025, SE = 0.038, p = 0.52) or on BD (IVW; b = 0.020, SE = 0.012, p = 0.10). Sensitivity analyses confirmed that 25(OH)vitamin D concentrations were not significantly associated with DS or BD. The findings from this MR study indicate no causal relationship between vitamin D concentrations and depressive symptoms, or broad depression. Conflicting findings from observational studies might have resulted from residual confounding or reverse causation. article_number: '1085' author: - first_name: Lars full_name: Libuda, Lars id: '88682' last_name: Libuda orcid: 0000-0003-1603-3133 - first_name: Björn-Hergen full_name: Laabs, Björn-Hergen last_name: Laabs - first_name: Christine full_name: Ludwig, Christine last_name: Ludwig - first_name: Judith full_name: Bühlmeier, Judith id: '89838' last_name: Bühlmeier - first_name: Jochen full_name: Antel, Jochen last_name: Antel - first_name: Anke full_name: Hinney, Anke last_name: Hinney - first_name: Roaa full_name: Naaresh, Roaa last_name: Naaresh - first_name: Manuel full_name: Föcker, Manuel last_name: Föcker - first_name: Johannes full_name: Hebebrand, Johannes last_name: Hebebrand - first_name: Inke R. full_name: König, Inke R. last_name: König - first_name: Triinu full_name: Peters, Triinu last_name: Peters citation: ama: 'Libuda L, Laabs B-H, Ludwig C, et al. Vitamin D and the Risk of Depression: A Causal Relationship? Findings from a Mendelian Randomization Study. Nutrients. Published online 2019. doi:10.3390/nu11051085' apa: 'Libuda, L., Laabs, B.-H., Ludwig, C., Bühlmeier, J., Antel, J., Hinney, A., Naaresh, R., Föcker, M., Hebebrand, J., König, I. R., & Peters, T. (2019). Vitamin D and the Risk of Depression: A Causal Relationship? Findings from a Mendelian Randomization Study. Nutrients, Article 1085. https://doi.org/10.3390/nu11051085' bibtex: '@article{Libuda_Laabs_Ludwig_Bühlmeier_Antel_Hinney_Naaresh_Föcker_Hebebrand_König_et al._2019, title={Vitamin D and the Risk of Depression: A Causal Relationship? Findings from a Mendelian Randomization Study}, DOI={10.3390/nu11051085}, number={1085}, journal={Nutrients}, author={Libuda, Lars and Laabs, Björn-Hergen and Ludwig, Christine and Bühlmeier, Judith and Antel, Jochen and Hinney, Anke and Naaresh, Roaa and Föcker, Manuel and Hebebrand, Johannes and König, Inke R. and et al.}, year={2019} }' chicago: 'Libuda, Lars, Björn-Hergen Laabs, Christine Ludwig, Judith Bühlmeier, Jochen Antel, Anke Hinney, Roaa Naaresh, et al. “Vitamin D and the Risk of Depression: A Causal Relationship? Findings from a Mendelian Randomization Study.” Nutrients, 2019. https://doi.org/10.3390/nu11051085.' ieee: 'L. Libuda et al., “Vitamin D and the Risk of Depression: A Causal Relationship? Findings from a Mendelian Randomization Study,” Nutrients, Art. no. 1085, 2019, doi: 10.3390/nu11051085.' mla: 'Libuda, Lars, et al. “Vitamin D and the Risk of Depression: A Causal Relationship? Findings from a Mendelian Randomization Study.” Nutrients, 1085, 2019, doi:10.3390/nu11051085.' short: L. Libuda, B.-H. Laabs, C. Ludwig, J. Bühlmeier, J. Antel, A. Hinney, R. Naaresh, M. Föcker, J. Hebebrand, I.R. König, T. Peters, Nutrients (2019). date_created: 2021-11-01T19:27:13Z date_updated: 2022-09-15T09:50:10Z department: - _id: '35' - _id: '22' - _id: '395' doi: 10.3390/nu11051085 extern: '1' language: - iso: eng publication: Nutrients publication_identifier: issn: - 2072-6643 publication_status: published status: public title: 'Vitamin D and the Risk of Depression: A Causal Relationship? Findings from a Mendelian Randomization Study' type: journal_article user_id: '89838' year: '2019' ... --- _id: '27025' author: - first_name: Nadja full_name: Knoll-Pientka, Nadja last_name: Knoll-Pientka - first_name: Judith full_name: Bühlmeier, Judith id: '89838' last_name: Bühlmeier - first_name: Triinu full_name: Peters, Triinu last_name: Peters - first_name: Muriel full_name: Albrecht, Muriel last_name: Albrecht - first_name: Frederike full_name: Adams, Frederike last_name: Adams - first_name: Katharina full_name: Wustrau, Katharina last_name: Wustrau - first_name: Martin full_name: Teufel, Martin last_name: Teufel - first_name: Johannes full_name: Hebebrand, Johannes last_name: Hebebrand - first_name: Manuel full_name: Föcker, Manuel last_name: Föcker - first_name: Lars full_name: Libuda, Lars id: '88682' last_name: Libuda orcid: 0000-0003-1603-3133 citation: ama: 'Knoll-Pientka N, Bühlmeier J, Peters T, et al. Risk factors for a low weight gain in the early stage of adolescent anorexia nervosa inpatient treatment: findings from a pilot study. Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity. Published online 2019:911-919. doi:10.1007/s40519-019-00705-9' apa: 'Knoll-Pientka, N., Bühlmeier, J., Peters, T., Albrecht, M., Adams, F., Wustrau, K., Teufel, M., Hebebrand, J., Föcker, M., & Libuda, L. (2019). Risk factors for a low weight gain in the early stage of adolescent anorexia nervosa inpatient treatment: findings from a pilot study. Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity, 911–919. https://doi.org/10.1007/s40519-019-00705-9' bibtex: '@article{Knoll-Pientka_Bühlmeier_Peters_Albrecht_Adams_Wustrau_Teufel_Hebebrand_Föcker_Libuda_2019, title={Risk factors for a low weight gain in the early stage of adolescent anorexia nervosa inpatient treatment: findings from a pilot study}, DOI={10.1007/s40519-019-00705-9}, journal={Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity}, author={Knoll-Pientka, Nadja and Bühlmeier, Judith and Peters, Triinu and Albrecht, Muriel and Adams, Frederike and Wustrau, Katharina and Teufel, Martin and Hebebrand, Johannes and Föcker, Manuel and Libuda, Lars}, year={2019}, pages={911–919} }' chicago: 'Knoll-Pientka, Nadja, Judith Bühlmeier, Triinu Peters, Muriel Albrecht, Frederike Adams, Katharina Wustrau, Martin Teufel, Johannes Hebebrand, Manuel Föcker, and Lars Libuda. “Risk Factors for a Low Weight Gain in the Early Stage of Adolescent Anorexia Nervosa Inpatient Treatment: Findings from a Pilot Study.” Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity, 2019, 911–19. https://doi.org/10.1007/s40519-019-00705-9.' ieee: 'N. Knoll-Pientka et al., “Risk factors for a low weight gain in the early stage of adolescent anorexia nervosa inpatient treatment: findings from a pilot study,” Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity, pp. 911–919, 2019, doi: 10.1007/s40519-019-00705-9.' mla: 'Knoll-Pientka, Nadja, et al. “Risk Factors for a Low Weight Gain in the Early Stage of Adolescent Anorexia Nervosa Inpatient Treatment: Findings from a Pilot Study.” Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity, 2019, pp. 911–19, doi:10.1007/s40519-019-00705-9.' short: N. Knoll-Pientka, J. Bühlmeier, T. Peters, M. Albrecht, F. Adams, K. Wustrau, M. Teufel, J. Hebebrand, M. Föcker, L. Libuda, Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity (2019) 911–919. date_created: 2021-11-01T19:22:52Z date_updated: 2022-09-15T09:49:32Z department: - _id: '35' - _id: '22' - _id: '395' doi: 10.1007/s40519-019-00705-9 extern: '1' language: - iso: eng page: 911-919 publication: Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity publication_identifier: issn: - 1590-1262 publication_status: published status: public title: 'Risk factors for a low weight gain in the early stage of adolescent anorexia nervosa inpatient treatment: findings from a pilot study' type: journal_article user_id: '89838' year: '2019' ... --- _id: '27521' author: - first_name: Johannes full_name: Hebebrand, Johannes last_name: Hebebrand - first_name: Gabriella full_name: Milos, Gabriella last_name: Milos - first_name: Martin full_name: Wabitsch, Martin last_name: Wabitsch - first_name: Martin full_name: Teufel, Martin last_name: Teufel - first_name: Dagmar full_name: Führer, Dagmar last_name: Führer - first_name: Judith full_name: Bühlmeier, Judith id: '89838' last_name: Bühlmeier - first_name: Lars full_name: Libuda, Lars id: '88682' last_name: Libuda orcid: 0000-0003-1603-3133 - first_name: Christine full_name: Ludwig, Christine last_name: Ludwig - first_name: Jochen full_name: Antel, Jochen last_name: Antel citation: ama: Hebebrand J, Milos G, Wabitsch M, et al. Clinical Trials Required to Assess Potential Benefits and Side Effects of Treatment of Patients With Anorexia Nervosa With Recombinant Human Leptin. Frontiers in Psychology. Published online 2019. doi:10.3389/fpsyg.2019.00769 apa: Hebebrand, J., Milos, G., Wabitsch, M., Teufel, M., Führer, D., Bühlmeier, J., Libuda, L., Ludwig, C., & Antel, J. (2019). Clinical Trials Required to Assess Potential Benefits and Side Effects of Treatment of Patients With Anorexia Nervosa With Recombinant Human Leptin. Frontiers in Psychology. https://doi.org/10.3389/fpsyg.2019.00769 bibtex: '@article{Hebebrand_Milos_Wabitsch_Teufel_Führer_Bühlmeier_Libuda_Ludwig_Antel_2019, title={Clinical Trials Required to Assess Potential Benefits and Side Effects of Treatment of Patients With Anorexia Nervosa With Recombinant Human Leptin}, DOI={10.3389/fpsyg.2019.00769}, journal={Frontiers in Psychology}, author={Hebebrand, Johannes and Milos, Gabriella and Wabitsch, Martin and Teufel, Martin and Führer, Dagmar and Bühlmeier, Judith and Libuda, Lars and Ludwig, Christine and Antel, Jochen}, year={2019} }' chicago: Hebebrand, Johannes, Gabriella Milos, Martin Wabitsch, Martin Teufel, Dagmar Führer, Judith Bühlmeier, Lars Libuda, Christine Ludwig, and Jochen Antel. “Clinical Trials Required to Assess Potential Benefits and Side Effects of Treatment of Patients With Anorexia Nervosa With Recombinant Human Leptin.” Frontiers in Psychology, 2019. https://doi.org/10.3389/fpsyg.2019.00769. ieee: 'J. Hebebrand et al., “Clinical Trials Required to Assess Potential Benefits and Side Effects of Treatment of Patients With Anorexia Nervosa With Recombinant Human Leptin,” Frontiers in Psychology, 2019, doi: 10.3389/fpsyg.2019.00769.' mla: Hebebrand, Johannes, et al. “Clinical Trials Required to Assess Potential Benefits and Side Effects of Treatment of Patients With Anorexia Nervosa With Recombinant Human Leptin.” Frontiers in Psychology, 2019, doi:10.3389/fpsyg.2019.00769. short: J. Hebebrand, G. Milos, M. Wabitsch, M. Teufel, D. Führer, J. Bühlmeier, L. Libuda, C. Ludwig, J. Antel, Frontiers in Psychology (2019). date_created: 2021-11-17T11:03:32Z date_updated: 2022-09-15T09:49:02Z department: - _id: '35' - _id: '22' - _id: '395' doi: 10.3389/fpsyg.2019.00769 extern: '1' language: - iso: eng publication: Frontiers in Psychology publication_identifier: issn: - 1664-1078 publication_status: published status: public title: Clinical Trials Required to Assess Potential Benefits and Side Effects of Treatment of Patients With Anorexia Nervosa With Recombinant Human Leptin type: journal_article user_id: '89838' year: '2019' ... --- _id: '33401' abstract: - lang: eng text: "Zusammenfassung\r\n Hintergrund Die begleitende Ernährungstherapie von Intensivpatienten stellt eine besondere Herausforderung in der klinischen Routine dar und erfordert die Implementation von leitlinienbasierten Handlungsanweisungen.\r\n Methoden In einer retrospektiven Analyse wurde die Umsetzung der klinikinternen Handlungsanweisung zur Ernährung kritisch kranker Patienten (Gültigkeitszeitraum September 2013 bis Januar 2016) sowie der Anordnung zur Ernährungstherapie auf einer operativen Intensivstation des Universitätsklinikums Bonn an Daten des Ernährungsmanagements von 31 Langzeit-Intensivpatienten (7 Frauen; Alter: 60 ± 17 Jahre; BMI: 28 ± 10 kg/m2; Dauer des Intensivaufenthalts: 34 ± 16 Tage) evaluiert. Ausgewertet wurden Daten zur Initiation, zum Ablauf sowie zur Berechnung und Umsetzung der Energie- und Proteinzufuhr. Dazu wurden jeweils die im Stationsalltag angeordnete bzw. protokollierte Zufuhr, die protokollierte Zufuhr abzüglich Reflux sowie das retrospektiv beurteilte Ziel, welches durch die klinikinterne Handlungsanweisung indiziert war, miteinander verglichen (linear gemischtes Modell).\r\n Ergebnisse Mit der enteralen Ernährung wurde im Mittel an Tag 4 ± 3, mit der (supplementierenden) parenteralen an Tag 3 ± 3 begonnen. Die Energiezufuhr wurde mit Korrekturfaktoren als ein Vielfaches des Grundumsatzes nach Harris & Benedict berechnet. Der individuell verwendete Korrekturfaktor zur Berechnung der angeordneten Energiezufuhr wich über die gesamte Dauer des stationären Aufenthalts 0,1 ± 0,3 vom retrospektiv als angemessen erachteten Korrekturfaktor ab. Hieraus resultierte eine Abweichung der angeordneten Energiezufuhr vom Energieziel von 123 ± 528 kcal/24 h. Insbesondere in den Tagen 1 – 10 betrug die Abweichung des angeordneten vom retrospektiv als angemessen erachteten Korrekturfaktor 0,2 ± 0,4, was zu einer Differenz zwischen angeordneter Energiezufuhr und Energieziel von 426 ± 772 kcal/24 h führte. Die protokollierte Proteinzufuhr lag über die gesamte Behandlungsdauer bei 1,1 g/kg KG/24 h, während das retrospektiv ermittelte Proteinziel 1,0 g/kg KG/24 h betrug.\r\n Schlussfolgerung Die Analyse liefert vertrauenswürdige Daten zur Implementation einer individualisierten Ernährungstherapie von Langzeit-Intensivpatienten auf einer operativen Intensivstation; diese können zur Weiterentwicklung von entsprechenden Handlungsanweisungen genutzt werden. Defizite bestehen sowohl im zeitlichen Ablauf (zu später Beginn) als auch in der Anordnung der Energie-/Nährstoffzufuhr. Umfassende Schulungen des ärztlichen und pflegerischen Personals zur Anwendung/Umsetzung der Ernährungstherapie sind zu empfehlen." author: - first_name: Ellen full_name: Dresen, Ellen last_name: Dresen - first_name: Carsten full_name: Weißbrich, Carsten last_name: Weißbrich - first_name: Judith full_name: Bühlmeier, Judith id: '89838' last_name: Bühlmeier - first_name: Christina full_name: Weisheit, Christina last_name: Weisheit - first_name: Sarah full_name: Egert, Sarah last_name: Egert - first_name: Christian full_name: Putensen, Christian last_name: Putensen - first_name: Peter full_name: Stehle, Peter last_name: Stehle citation: ama: Dresen E, Weißbrich C, Bühlmeier J, et al. Retrospektive Evaluation der Umsetzung einer klinikinternen Handlungsanweisung zur Ernährungstherapie von Intensivpatienten. Aktuelle Ernährungsmedizin. 2019;44(04):237-247. doi:10.1055/a-0915-4994 apa: Dresen, E., Weißbrich, C., Bühlmeier, J., Weisheit, C., Egert, S., Putensen, C., & Stehle, P. (2019). Retrospektive Evaluation der Umsetzung einer klinikinternen Handlungsanweisung zur Ernährungstherapie von Intensivpatienten. Aktuelle Ernährungsmedizin, 44(04), 237–247. https://doi.org/10.1055/a-0915-4994 bibtex: '@article{Dresen_Weißbrich_Bühlmeier_Weisheit_Egert_Putensen_Stehle_2019, title={Retrospektive Evaluation der Umsetzung einer klinikinternen Handlungsanweisung zur Ernährungstherapie von Intensivpatienten}, volume={44}, DOI={10.1055/a-0915-4994}, number={04}, journal={Aktuelle Ernährungsmedizin}, publisher={Georg Thieme Verlag KG}, author={Dresen, Ellen and Weißbrich, Carsten and Bühlmeier, Judith and Weisheit, Christina and Egert, Sarah and Putensen, Christian and Stehle, Peter}, year={2019}, pages={237–247} }' chicago: 'Dresen, Ellen, Carsten Weißbrich, Judith Bühlmeier, Christina Weisheit, Sarah Egert, Christian Putensen, and Peter Stehle. “Retrospektive Evaluation der Umsetzung einer klinikinternen Handlungsanweisung zur Ernährungstherapie von Intensivpatienten.” Aktuelle Ernährungsmedizin 44, no. 04 (2019): 237–47. https://doi.org/10.1055/a-0915-4994.' ieee: 'E. Dresen et al., “Retrospektive Evaluation der Umsetzung einer klinikinternen Handlungsanweisung zur Ernährungstherapie von Intensivpatienten,” Aktuelle Ernährungsmedizin, vol. 44, no. 04, pp. 237–247, 2019, doi: 10.1055/a-0915-4994.' mla: Dresen, Ellen, et al. “Retrospektive Evaluation der Umsetzung einer klinikinternen Handlungsanweisung zur Ernährungstherapie von Intensivpatienten.” Aktuelle Ernährungsmedizin, vol. 44, no. 04, Georg Thieme Verlag KG, 2019, pp. 237–47, doi:10.1055/a-0915-4994. short: E. Dresen, C. Weißbrich, J. Bühlmeier, C. Weisheit, S. Egert, C. Putensen, P. Stehle, Aktuelle Ernährungsmedizin 44 (2019) 237–247. date_created: 2022-09-15T09:51:53Z date_updated: 2022-09-15T09:52:14Z doi: 10.1055/a-0915-4994 extern: '1' intvolume: ' 44' issue: '04' keyword: - Nutrition and Dietetics - Medicine (miscellaneous) language: - iso: ger page: 237-247 publication: Aktuelle Ernährungsmedizin publication_identifier: issn: - 0341-0501 - 1438-9916 publication_status: published publisher: Georg Thieme Verlag KG status: public title: Retrospektive Evaluation der Umsetzung einer klinikinternen Handlungsanweisung zur Ernährungstherapie von Intensivpatienten type: journal_article user_id: '89838' volume: 44 year: '2019' ... --- _id: '33390' author: - first_name: P. full_name: Frings-Meuthen, P. last_name: Frings-Meuthen - first_name: G. full_name: Bernhardt, G. last_name: Bernhardt - first_name: Judith full_name: Bühlmeier, Judith id: '89838' last_name: Bühlmeier - first_name: N. full_name: Baecker, N. last_name: Baecker - first_name: F. full_name: May, F. last_name: May - first_name: M. full_name: Heer, M. last_name: Heer citation: ama: 'Frings-Meuthen P, Bernhardt G, Bühlmeier J, Baecker N, May F, Heer M. The negative effect of unloading exceeds the bone-sparing effect of alkaline supplementation: a bed rest study. Osteoporosis International. 2018;30(2):431-439. doi:10.1007/s00198-018-4703-6' apa: 'Frings-Meuthen, P., Bernhardt, G., Bühlmeier, J., Baecker, N., May, F., & Heer, M. (2018). The negative effect of unloading exceeds the bone-sparing effect of alkaline supplementation: a bed rest study. Osteoporosis International, 30(2), 431–439. https://doi.org/10.1007/s00198-018-4703-6' bibtex: '@article{Frings-Meuthen_Bernhardt_Bühlmeier_Baecker_May_Heer_2018, title={The negative effect of unloading exceeds the bone-sparing effect of alkaline supplementation: a bed rest study}, volume={30}, DOI={10.1007/s00198-018-4703-6}, number={2}, journal={Osteoporosis International}, publisher={Springer Science and Business Media LLC}, author={Frings-Meuthen, P. and Bernhardt, G. and Bühlmeier, Judith and Baecker, N. and May, F. and Heer, M.}, year={2018}, pages={431–439} }' chicago: 'Frings-Meuthen, P., G. Bernhardt, Judith Bühlmeier, N. Baecker, F. May, and M. Heer. “The Negative Effect of Unloading Exceeds the Bone-Sparing Effect of Alkaline Supplementation: A Bed Rest Study.” Osteoporosis International 30, no. 2 (2018): 431–39. https://doi.org/10.1007/s00198-018-4703-6.' ieee: 'P. Frings-Meuthen, G. Bernhardt, J. Bühlmeier, N. Baecker, F. May, and M. Heer, “The negative effect of unloading exceeds the bone-sparing effect of alkaline supplementation: a bed rest study,” Osteoporosis International, vol. 30, no. 2, pp. 431–439, 2018, doi: 10.1007/s00198-018-4703-6.' mla: 'Frings-Meuthen, P., et al. “The Negative Effect of Unloading Exceeds the Bone-Sparing Effect of Alkaline Supplementation: A Bed Rest Study.” Osteoporosis International, vol. 30, no. 2, Springer Science and Business Media LLC, 2018, pp. 431–39, doi:10.1007/s00198-018-4703-6.' short: P. Frings-Meuthen, G. Bernhardt, J. Bühlmeier, N. Baecker, F. May, M. Heer, Osteoporosis International 30 (2018) 431–439. date_created: 2022-09-15T09:32:11Z date_updated: 2022-09-15T09:44:04Z doi: 10.1007/s00198-018-4703-6 extern: '1' intvolume: ' 30' issue: '2' keyword: - Endocrinology - Diabetes and Metabolism language: - iso: eng page: 431-439 publication: Osteoporosis International publication_identifier: issn: - 0937-941X - 1433-2965 publication_status: published publisher: Springer Science and Business Media LLC status: public title: 'The negative effect of unloading exceeds the bone-sparing effect of alkaline supplementation: a bed rest study' type: journal_article user_id: '89838' volume: 30 year: '2018' ... --- _id: '33392' abstract: - lang: eng text: "Abstract\r\n \r\n Context\r\n \ The effects of energy-balanced bed rest on metabolic flexibility have not been thoroughly examined.\r\n \r\n \ \r\n Objective\r\n \ We investigated the effects of 21 days of bed rest, with and without whey protein supplementation, on metabolic flexibility while maintaining energy balance. We hypothesized that protein supplementation mitigates metabolic inflexibility by preventing muscle atrophy.\r\n \r\n \ \r\n Design and Setting\r\n \ Randomized crossover longitudinal study conducted at the German Aerospace Center, Cologne, Germany.\r\n \r\n \ \r\n Participants and Interventions\r\n \ Ten healthy men were randomly assigned to dietary countermeasure or isocaloric control diet during a 21-day bed rest.\r\n \r\n \ \r\n Outcome Measures\r\n \ Before and at the end of the bed rest, metabolic flexibility was assessed during a meal test. Secondary outcomes were glucose tolerance by oral glucose tolerance test, body composition by dual energy X-ray absorptiometry, ectopic fat storage by magnetic resonance imaging, and inflammation and oxidative stress markers.\r\n \r\n \r\n \ Results\r\n Bed rest decreased the ability to switch from fat to carbohydrate oxidation when transitioning from fasted to fed states (i.e., metabolic inflexibility), antioxidant capacity, fat-free mass (FFM), and muscle insulin sensitivity along with greater fat deposition in muscle (P &lt; 0.05 for all). Changes in fasting insulin and inflammation were not observed. However, glucose tolerance was reduced during acute overfeeding. Protein supplementation did not prevent FFM loss and metabolic alterations.\r\n \ \r\n \r\n Conclusions\r\n \ Physical inactivity triggers metabolic inflexibility, even when energy balance is maintained. Although reduced insulin sensitivity and increased fat deposition were observed at the muscle level, systemic glucose intolerance was detected only in response to a moderately high-fat meal. This finding supports the role of physical inactivity in metabolic inflexibility and suggests that metabolic inflexibility precedes systemic glucose intolerance.\r\n " author: - first_name: Floriane full_name: Rudwill, Floriane last_name: Rudwill - first_name: Donal full_name: O’Gorman, Donal last_name: O’Gorman - first_name: Etienne full_name: Lefai, Etienne last_name: Lefai - first_name: Isabelle full_name: Chery, Isabelle last_name: Chery - first_name: Alexandre full_name: Zahariev, Alexandre last_name: Zahariev - first_name: Sylvie full_name: Normand, Sylvie last_name: Normand - first_name: Allan F full_name: Pagano, Allan F last_name: Pagano - first_name: Angèle full_name: Chopard, Angèle last_name: Chopard - first_name: Anthony full_name: Damiot, Anthony last_name: Damiot - first_name: Claire full_name: Laurens, Claire last_name: Laurens - first_name: Leanne full_name: Hodson, Leanne last_name: Hodson - first_name: Emmanuelle full_name: Canet-Soulas, Emmanuelle last_name: Canet-Soulas - first_name: Martina full_name: Heer, Martina last_name: Heer - first_name: Petra Frings full_name: Meuthen, Petra Frings last_name: Meuthen - first_name: Judith full_name: Bühlmeier, Judith id: '89838' last_name: Bühlmeier - first_name: Natalie full_name: Baecker, Natalie last_name: Baecker - first_name: Laure full_name: Meiller, Laure last_name: Meiller - first_name: Guillemette full_name: Gauquelin-Koch, Guillemette last_name: Gauquelin-Koch - first_name: Stéphane full_name: Blanc, Stéphane last_name: Blanc - first_name: Chantal full_name: Simon, Chantal last_name: Simon - first_name: Audrey full_name: Bergouignan, Audrey last_name: Bergouignan citation: ama: Rudwill F, O’Gorman D, Lefai E, et al. Metabolic Inflexibility Is an Early Marker of Bed-Rest–Induced Glucose Intolerance Even When Fat Mass Is Stable. The Journal of Clinical Endocrinology &amp; Metabolism. 2018;103(5):1910-1920. doi:10.1210/jc.2017-02267 apa: Rudwill, F., O’Gorman, D., Lefai, E., Chery, I., Zahariev, A., Normand, S., Pagano, A. F., Chopard, A., Damiot, A., Laurens, C., Hodson, L., Canet-Soulas, E., Heer, M., Meuthen, P. F., Bühlmeier, J., Baecker, N., Meiller, L., Gauquelin-Koch, G., Blanc, S., … Bergouignan, A. (2018). Metabolic Inflexibility Is an Early Marker of Bed-Rest–Induced Glucose Intolerance Even When Fat Mass Is Stable. The Journal of Clinical Endocrinology &amp; Metabolism, 103(5), 1910–1920. https://doi.org/10.1210/jc.2017-02267 bibtex: '@article{Rudwill_O’Gorman_Lefai_Chery_Zahariev_Normand_Pagano_Chopard_Damiot_Laurens_et al._2018, title={Metabolic Inflexibility Is an Early Marker of Bed-Rest–Induced Glucose Intolerance Even When Fat Mass Is Stable}, volume={103}, DOI={10.1210/jc.2017-02267}, number={5}, journal={The Journal of Clinical Endocrinology &amp; Metabolism}, publisher={The Endocrine Society}, author={Rudwill, Floriane and O’Gorman, Donal and Lefai, Etienne and Chery, Isabelle and Zahariev, Alexandre and Normand, Sylvie and Pagano, Allan F and Chopard, Angèle and Damiot, Anthony and Laurens, Claire and et al.}, year={2018}, pages={1910–1920} }' chicago: 'Rudwill, Floriane, Donal O’Gorman, Etienne Lefai, Isabelle Chery, Alexandre Zahariev, Sylvie Normand, Allan F Pagano, et al. “Metabolic Inflexibility Is an Early Marker of Bed-Rest–Induced Glucose Intolerance Even When Fat Mass Is Stable.” The Journal of Clinical Endocrinology &amp; Metabolism 103, no. 5 (2018): 1910–20. https://doi.org/10.1210/jc.2017-02267.' ieee: 'F. Rudwill et al., “Metabolic Inflexibility Is an Early Marker of Bed-Rest–Induced Glucose Intolerance Even When Fat Mass Is Stable,” The Journal of Clinical Endocrinology &amp; Metabolism, vol. 103, no. 5, pp. 1910–1920, 2018, doi: 10.1210/jc.2017-02267.' mla: Rudwill, Floriane, et al. “Metabolic Inflexibility Is an Early Marker of Bed-Rest–Induced Glucose Intolerance Even When Fat Mass Is Stable.” The Journal of Clinical Endocrinology &amp; Metabolism, vol. 103, no. 5, The Endocrine Society, 2018, pp. 1910–20, doi:10.1210/jc.2017-02267. short: F. Rudwill, D. O’Gorman, E. Lefai, I. Chery, A. Zahariev, S. Normand, A.F. Pagano, A. Chopard, A. Damiot, C. Laurens, L. Hodson, E. Canet-Soulas, M. Heer, P.F. Meuthen, J. Bühlmeier, N. Baecker, L. Meiller, G. Gauquelin-Koch, S. Blanc, C. Simon, A. Bergouignan, The Journal of Clinical Endocrinology &amp; Metabolism 103 (2018) 1910–1920. date_created: 2022-09-15T09:33:08Z date_updated: 2022-09-15T09:44:47Z doi: 10.1210/jc.2017-02267 extern: '1' intvolume: ' 103' issue: '5' keyword: - Biochemistry (medical) - Clinical Biochemistry - Endocrinology - Biochemistry - Endocrinology - Diabetes and Metabolism language: - iso: eng page: 1910-1920 publication: The Journal of Clinical Endocrinology & Metabolism publication_identifier: issn: - 0021-972X - 1945-7197 publication_status: published publisher: The Endocrine Society status: public title: Metabolic Inflexibility Is an Early Marker of Bed-Rest–Induced Glucose Intolerance Even When Fat Mass Is Stable type: journal_article user_id: '89838' volume: 103 year: '2018' ...