@article{65374,
  author       = {{Schlarbaum, Laura and Jankovic, Nicole and Bühlmeier, Judith and Hohoff, Eva and Dankers, Rhea and Engler, Harald and Hirtz, Raphael and Zwanziger, Denise and Grasemann, Corinna and Peters, Triinu and Hinney, Anke and Antel, Jochen and Föcker, Manuel and Libuda, Lars}},
  issn         = {{1436-6207}},
  journal      = {{European Journal of Nutrition}},
  number       = {{3}},
  publisher    = {{Springer Science and Business Media LLC}},
  title        = {{{Does inflammation moderate the effect of vitamin D supplementation on depressive symptoms? Results of an interventional study in children and adolescents}}},
  doi          = {{10.1007/s00394-026-03920-0}},
  volume       = {{65}},
  year         = {{2026}},
}

@article{65375,
  abstract     = {{<jats:title>Abstract</jats:title>
                  <jats:p>Vitamin D has been associated with depression, potentially via anti-inflammatory mechanisms, yet data is scarce, particularly in adolescence. We investigated (1) whether lower vitamin D status is associated with greater depression severity and (2) whether this association is statistically moderated by inflammation in patients of a child and adolescent psychiatry department. At admission fasting morning venous blood was drawn. Serum vitamin D (25(OH)D) and C-reactive protein (CRP) were analyzed in all participants [n=465 (64.7%♀; 11.3-18.9 years)]. In a subsample [n=177], we additionally measured tumor necrosis factor-alpha, interferon-gamma and interleukin (IL)-1β, IL-6, IL-8, IL-10. Depression severity was assessed by the Beck Depression Inventory-II (BDI-II) [n=450], the Diagnostic System for Mental Disorders in Childhood and Adolescence via self-assessment (DISYPS Self) [n=441], and parent-assessment (DISYPS Proxy) [n=422]. Overall, 43.2% [n=201] were at risk for vitamin D deficiency (&lt;30nmol/L), and 73.5%-83.2% –depending on assessment tool– showed at least mild depression. Linear regression revealed an inverse association between 25(OH)D and BDI-II in both crude and CRP-adjusted full-sample models. Logistic regressions showed a robust inverse association between 25(OH)D and DISYPS Proxy, but not for DISYPS Self. Although 25(OH)D was inversely correlated with some pro-inflammatory markers, neither their inclusion in regression models nor formal mediation analyses supported inflammation as a mediator of the vitamin D–depression association. Overall, our results suggest that vitamin D relates modestly to both depression and inflammation in adolescence. However, based on the measured parameters, we cannot confirm that anti-inflammatory effects are the link between vitamin D and depression.</jats:p>}},
  author       = {{Schlarbaum, Laura and Jankovic, Nicole and Bühlmeier, Judith and Engler, Harald and Hirtz, Raphael and Grasemann, Corinna and Peters, Triinu and Hinney, Anke and Antel, Jochen and Hebebrand, Johannes and Föcker, Manuel and Libuda, Lars}},
  issn         = {{0007-1145}},
  journal      = {{British Journal of Nutrition}},
  pages        = {{1--37}},
  publisher    = {{Cambridge University Press (CUP)}},
  title        = {{{Does inflammation explain the association between vitamin D and depression? Results of a cross-sectional study in children and adolescents}}},
  doi          = {{10.1017/s0007114526106928}},
  year         = {{2026}},
}

@article{66301,
  author       = {{Schlarbaum, Laura and Jankovic, N. and Engler, H. and Hirtz, R. and Grasemann, C. and Peters, T. and Hinney, A. and Antel, J. and Hebebrand, J. and Föcker, M. and Libuda, Lars}},
  issn         = {{2772-4085}},
  journal      = {{Neuroscience Applied}},
  publisher    = {{Elsevier BV}},
  title        = {{{Vitamin D, inflammation and depressive symptoms in adolescents: analysis using observational and interventional data}}},
  doi          = {{10.1016/j.nsa.2026.106979}},
  volume       = {{5}},
  year         = {{2026}},
}

@article{66849,
  abstract     = {{<jats:title>Abstract</jats:title>
                  <jats:p>
                    Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (GFAP) are biomarkers of neuroaxonal and astrocytic damage but remain understudied in adolescent psychiatric populations. This study investigated sNfL and GFAP levels in 412 adolescents diagnosed with anorexia nervosa (AN) (
                    <jats:italic>n</jats:italic>
                     = 52), depression (
                    <jats:italic>n</jats:italic>
                     = 237), and other psychiatric disorders (
                    <jats:italic>n</jats:italic>
                     = 123). We assessed their diagnostic utility, correlation with disease severity, and longitudinal changes during AN treatment. Biomarkers were measured using Single Molecule Array technology, with Z-scores derived from reference datasets. Compared to population norms, both biomarkers were elevated in AN (sNfL: 1.15 ± 1.17; GFAP: 1.50 ± 0.84) and in depression (sNfL: 0.34 ± 1.10; GFAP: 0.58 ± 1.00). Patients with AN showed significantly higher biomarker levels than those with depression or other psychiatric disorders; importantly, this distinction remained evident in sensitivity analyses restricted to underweight individuals with depression. In AN, sNfL levels correlated with baseline weight loss (β = −0.45, R² = 0.20) and declined significantly during treatment, while GFAP changes were less pronounced. Neither marker correlated with depressive symptom severity. Bootstrapped ROC analyses showed moderate-to-good discriminatory power (AUCs 0.70–0.84) for distinguishing AN from depression. These findings suggest that neuroaxonal and astrocytic stress is a component of adolescent psychopathology, particularly in AN. sNfL appears sensitive to starvation-related neurobiological changes, with levels normalizing alongside weight restoration. GFAP showed similar but less robust trends. Accordingly, the observed biomarker changes reflect more than underweight alone, supporting a potential role in differential diagnosis and treatment monitoring.
                  </jats:p>}},
  author       = {{Pawlitzki, Marc and Masanneck, Lars and Schlarbaum, Laura and Jankovic, Nicole and Bittner, Stefan and Steffen, Falk and Kuhle, Jens and Benkert, Pascal and Repple, Jonathan and Bühlmeier, Judith and Hinney, Anke and Hebebrand, Johannes and Hirtz, Raphael and G. Meuth, Sven and Libuda, Lars and Föcker, Manuel}},
  issn         = {{2158-3188}},
  journal      = {{Translational Psychiatry}},
  number       = {{1}},
  publisher    = {{Springer Science and Business Media LLC}},
  title        = {{{Exploring serum biomarkers in paediatric psychiatry: the impact of NfL and GFAP}}},
  doi          = {{10.1038/s41398-026-04347-1}},
  volume       = {{16}},
  year         = {{2026}},
}

@article{66851,
  author       = {{Schlarbaum, Laura and Jankovic, N. and Engler, H. and Hirtz, R. and Grasemann, C. and Peters, T. and Hinney, A. and Antel, J. and Hebebrand, J. and Föcker, M. and Libuda, Lars}},
  issn         = {{2772-4085}},
  journal      = {{Neuroscience Applied}},
  publisher    = {{Elsevier BV}},
  title        = {{{Vitamin D, inflammation and depressive symptoms in adolescents: analysis using observational and interventional data}}},
  doi          = {{10.1016/j.nsa.2026.106979}},
  volume       = {{5}},
  year         = {{2026}},
}

@article{53788,
  abstract     = {{<jats:p>Globally, an unbalanced diet causes more deaths than any other factor. Due to a lack of knowledge, it is difficult for consumers to select healthy foods at the point of sale. Although different front-of-pack labeling schemes exist, their informative value is limited due to small sets of considered parameters and lacking information on ingredient composition. We developed and evalauated a manufacture-independent approach to quantify ingredient composition of 294 ready-to eat salads (distinguished into 73 subgroups) as test set. Nutritional quality was assessed by the nutriRECIPE-Index and compared to the Nutri-Score. The nutriRECIPE-Index comprises the calculation of energy-adjusted nutrient density of 16 desirable and three undesirable nutrients, which are weighted according to their degree of supply in the population. We show that the nutriRECIPE-Index has stronger discriminatory power compared to the Nutri-Score and discriminates as well or even better in 63 out of the 73 subgroups. This was evident in groups where seemingly similar products were compared, e.g., potato salads (Nutri-Score: C only, nutriRECIPE-Index: B, C and D). Moreover, the nutriRECIPE-Index is adjustable to any target population’s specific needs and supply situation, such as seniors, and children. Hence, a more sophisticated distinction between single food products is possible using the nutriRECIPE-Index.</jats:p>}},
  author       = {{Schlarbaum, Laura and Forner, Frank and Bohn, Kristin and Amberg, Michael and Mäder, Patrick and Lorkowski, Stefan and Meier, Toni}},
  issn         = {{2304-8158}},
  journal      = {{Foods}},
  number       = {{24}},
  publisher    = {{MDPI AG}},
  title        = {{{Nutritional Assessment of Ready-to-Eat Salads in German Supermarkets: Comparison of the nutriRECIPE-Index and the Nutri-Score}}},
  doi          = {{10.3390/foods11244011}},
  volume       = {{11}},
  year         = {{2022}},
}