@article{37946, abstract = {{AbstractThe facile synthesis of highly functionalized building blocks with potential biological activity is of great interest to medicinal chemistry. The benzoxepinone core structures commonly exhibit biological activity. Thus, a short and efficient synthetic route towards benzoxepine containing scaffold, which enables late stage modification was developed. Namely, base-free catalytic Wittig reactions enabled the synthesis of bromobenzoxepinones from readily available starting materials. Subsequent, Suzuki–Miyaura and Stille reactions proved to be suitable methods to access a variety of benzoxepinone diaryl derivatives by late stage modification in only three steps. This three-step reaction sequence is suitable for high throughput applications and gives facile access to highly complex molecular structures, which are suitable for further functionalization. The antiproliferative properties of selected arylbenzoxepinones­ were tested in vitro on monolayer tumor cell line A549. Notably, in this initial screening, these compounds were found to be active in the micromolar range.}}, author = {{Werner, Thomas and Grandane, Aiga and Pudnika, Linda and Domraceva, Ilona and Zalubovskis, Raivis}}, issn = {{0039-7881}}, journal = {{Synthesis}}, keywords = {{Organic Chemistry, Catalysis}}, number = {{19}}, pages = {{3545--3554}}, publisher = {{Georg Thieme Verlag KG}}, title = {{{Base-Free Catalytic Wittig-/Cross-Coupling Reaction Sequence as Short Synthetic Strategy for the Preparation of Highly Functionalized Arylbenzoxepinones}}}, doi = {{10.1055/a-1509-6078}}, volume = {{53}}, year = {{2021}}, } @article{37947, author = {{Paradies, Jan and Andexer, Jennifer and Beifuss, Uwe and Beuerle, Florian and Brasholz, Malte and Breinbauer, Rolf and Ernst, Martin and Ganardi, Ruth and Gulder, Tobias A. M. and Hüttel, Wolfgang and Kath‐Schorr, Stephanie and Körber, Karsten and Kordes, Markus and Lehmann, Matthias and Lindel, Thomas and Luy, Burkhard and Mück‐Lichtenfeld, Christian and Muhle‐Goll, Claudia and Niemeyer, Jochen and Pfau, Roland and Pietruszka, Jörg and Röckl, Johannes L. and Schaschke, Norbert and Senge, Mathias O. and Straub, Bernd F. and Waldvogel, Siegfried R. and Werner, Thomas and Werz, Daniel B. and Winter, Christian}}, issn = {{1439-9598}}, journal = {{Nachrichten aus der Chemie}}, keywords = {{General Chemical Engineering, General Chemistry}}, number = {{3}}, pages = {{38--68}}, publisher = {{Wiley}}, title = {{{Organische Chemie}}}, doi = {{10.1002/nadc.20214105947}}, volume = {{69}}, year = {{2021}}, } @article{37944, abstract = {{

A Mn–PNP complex proved to be a suitable catalyst for the transfer hydrogenation of amides, carbamates, urea derivatives and even polyurethanes.

}}, author = {{Liu, Xin and Werner, Thomas}}, issn = {{2041-6520}}, journal = {{Chemical Science}}, keywords = {{General Chemistry}}, number = {{31}}, pages = {{10590--10597}}, publisher = {{Royal Society of Chemistry (RSC)}}, title = {{{Indirect reduction of CO2 and recycling of polymers by manganese-catalyzed transfer hydrogenation of amides, carbamates, urea derivatives, and polyurethanes}}}, doi = {{10.1039/d1sc02663a}}, volume = {{12}}, year = {{2021}}, } @article{37945, abstract = {{

PMHS proved to be a suitable terminal reductant for P(iii)/P(v) redox cycling with a methyl-substituted phosphetane as catalyst and BuOAc as solvent. The formation of water by silanol condensation was identified as main pathway of siloxane formation.

}}, author = {{Tönjes, Jan and Longwitz, Lars and Werner, Thomas}}, issn = {{1463-9262}}, journal = {{Green Chemistry}}, keywords = {{Pollution, Environmental Chemistry}}, number = {{13}}, pages = {{4852--4857}}, publisher = {{Royal Society of Chemistry (RSC)}}, title = {{{Poly(methylhydrosiloxane) as a reductant in the catalytic base-free Wittig reaction}}}, doi = {{10.1039/d1gc00953b}}, volume = {{23}}, year = {{2021}}, } @inproceedings{38080, author = {{Dahm, Stephan and Weigelt, Matthias and Rieger, M.}}, title = {{{Representations after mentally practiced one finger sequences are effector independent}}}, year = {{2021}}, } @article{37943, author = {{Wirth, Marisa A. and Longwitz, Lars and Kanwischer, Marion and Gros, Peter and Leinweber, Peter and Werner, Thomas}}, issn = {{0147-6513}}, journal = {{Ecotoxicology and Environmental Safety}}, keywords = {{Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health, Pollution, General Medicine}}, publisher = {{Elsevier BV}}, title = {{{AMPA-15N – Synthesis and application as standard compound in traceable degradation studies of glyphosate}}}, doi = {{10.1016/j.ecoenv.2021.112768}}, volume = {{225}}, year = {{2021}}, } @inproceedings{38082, author = {{Budde, Kirsten and Barela, J.A. and Figueiredo, G.A. and Weigelt, Matthias}}, title = {{{Mental body rotation with egocentric and object-based transformations in different postures: sitting vs. standing}}}, year = {{2021}}, } @article{35686, abstract = {{AbstractThe development of the frustrated Lewis pair catalyzed hydrogenation of tertiary and secondary amides is reviewed. Detailed insight into our strategies in order to overcome challenges during the reaction development process is provided. Furthermore, the developed chemistry is extended to the hydrogenation of polyamides and of trifluoroacetamides for the convenient introduction of trifluoroethyl groups into organic molecules.}}, author = {{Paradies, Jan and Köring, Laura and Sitte, Nikolai A.}}, issn = {{0039-7881}}, journal = {{Synthesis}}, keywords = {{Organic Chemistry, Catalysis}}, number = {{05}}, pages = {{1287--1300}}, publisher = {{Georg Thieme Verlag KG}}, title = {{{Towards the Development of Frustrated Lewis Pair (FLP) Catalyzed Hydrogenations of Tertiary and Secondary Carboxylic Amides}}}, doi = {{10.1055/a-1681-3972}}, volume = {{54}}, year = {{2021}}, } @article{35687, author = {{Zhou, Rundong and Paradies, Jan}}, issn = {{1434-193X}}, journal = {{European Journal of Organic Chemistry}}, keywords = {{Organic Chemistry, Physical and Theoretical Chemistry}}, number = {{46}}, pages = {{6334--6339}}, publisher = {{Wiley}}, title = {{{Borane Catalyzed Redox Isomerization of 2‐Amino Chalcones: Hydride Abstraction or Hydride Migration?}}}, doi = {{10.1002/ejoc.202100883}}, volume = {{2021}}, year = {{2021}}, } @article{22232, author = {{Wicker, Garrit and Schoch, Roland and Paradies, Jan}}, issn = {{1523-7060}}, journal = {{Organic Letters}}, pages = {{3626--3630}}, title = {{{Diastereoselective Synthesis of Dihydro-quinolin-4-ones by a Borane-Catalyzed Redox-Neutral endo-1,7-Hydride Shift}}}, doi = {{10.1021/acs.orglett.1c01018}}, year = {{2021}}, }