TY - JOUR AB - AbstractThe facile synthesis of highly functionalized building blocks with potential biological activity is of great interest to medicinal chemistry. The benzoxepinone core structures commonly exhibit biological activity. Thus, a short and efficient synthetic route towards benzoxepine containing scaffold, which enables late stage modification was developed. Namely, base-free catalytic Wittig reactions enabled the synthesis of bromobenzoxepinones from readily available starting materials. Subsequent, Suzuki–Miyaura and Stille reactions proved to be suitable methods to access a variety of benzoxepinone diaryl derivatives by late stage modification in only three steps. This three-step reaction sequence is suitable for high throughput applications and gives facile access to highly complex molecular structures, which are suitable for further functionalization. The antiproliferative properties of selected arylbenzoxepinones­ were tested in vitro on monolayer tumor cell line A549. Notably, in this initial screening, these compounds were found to be active in the micromolar range. AU - Werner, Thomas AU - Grandane, Aiga AU - Pudnika, Linda AU - Domraceva, Ilona AU - Zalubovskis, Raivis ID - 37946 IS - 19 JF - Synthesis KW - Organic Chemistry KW - Catalysis SN - 0039-7881 TI - Base-Free Catalytic Wittig-/Cross-Coupling Reaction Sequence as Short Synthetic Strategy for the Preparation of Highly Functionalized Arylbenzoxepinones VL - 53 ER - TY - JOUR AU - Paradies, Jan AU - Andexer, Jennifer AU - Beifuss, Uwe AU - Beuerle, Florian AU - Brasholz, Malte AU - Breinbauer, Rolf AU - Ernst, Martin AU - Ganardi, Ruth AU - Gulder, Tobias A. M. AU - Hüttel, Wolfgang AU - Kath‐Schorr, Stephanie AU - Körber, Karsten AU - Kordes, Markus AU - Lehmann, Matthias AU - Lindel, Thomas AU - Luy, Burkhard AU - Mück‐Lichtenfeld, Christian AU - Muhle‐Goll, Claudia AU - Niemeyer, Jochen AU - Pfau, Roland AU - Pietruszka, Jörg AU - Röckl, Johannes L. AU - Schaschke, Norbert AU - Senge, Mathias O. AU - Straub, Bernd F. AU - Waldvogel, Siegfried R. AU - Werner, Thomas AU - Werz, Daniel B. AU - Winter, Christian ID - 37947 IS - 3 JF - Nachrichten aus der Chemie KW - General Chemical Engineering KW - General Chemistry SN - 1439-9598 TI - Organische Chemie VL - 69 ER - TY - JOUR AB -

A Mn–PNP complex proved to be a suitable catalyst for the transfer hydrogenation of amides, carbamates, urea derivatives and even polyurethanes.

AU - Liu, Xin AU - Werner, Thomas ID - 37944 IS - 31 JF - Chemical Science KW - General Chemistry SN - 2041-6520 TI - Indirect reduction of CO2 and recycling of polymers by manganese-catalyzed transfer hydrogenation of amides, carbamates, urea derivatives, and polyurethanes VL - 12 ER - TY - JOUR AB -

PMHS proved to be a suitable terminal reductant for P(iii)/P(v) redox cycling with a methyl-substituted phosphetane as catalyst and BuOAc as solvent. The formation of water by silanol condensation was identified as main pathway of siloxane formation.

AU - Tönjes, Jan AU - Longwitz, Lars AU - Werner, Thomas ID - 37945 IS - 13 JF - Green Chemistry KW - Pollution KW - Environmental Chemistry SN - 1463-9262 TI - Poly(methylhydrosiloxane) as a reductant in the catalytic base-free Wittig reaction VL - 23 ER - TY - CONF AU - Dahm, Stephan AU - Weigelt, Matthias AU - Rieger, M. ID - 38080 TI - Representations after mentally practiced one finger sequences are effector independent ER - TY - JOUR AU - Wirth, Marisa A. AU - Longwitz, Lars AU - Kanwischer, Marion AU - Gros, Peter AU - Leinweber, Peter AU - Werner, Thomas ID - 37943 JF - Ecotoxicology and Environmental Safety KW - Health KW - Toxicology and Mutagenesis KW - Public Health KW - Environmental and Occupational Health KW - Pollution KW - General Medicine SN - 0147-6513 TI - AMPA-15N – Synthesis and application as standard compound in traceable degradation studies of glyphosate VL - 225 ER - TY - CONF AU - Budde, Kirsten AU - Barela, J.A. AU - Figueiredo, G.A. AU - Weigelt, Matthias ID - 38082 TI - Mental body rotation with egocentric and object-based transformations in different postures: sitting vs. standing ER - TY - JOUR AB - AbstractThe development of the frustrated Lewis pair catalyzed hydrogenation of tertiary and secondary amides is reviewed. Detailed insight into our strategies in order to overcome challenges during the reaction development process is provided. Furthermore, the developed chemistry is extended to the hydrogenation of polyamides and of trifluoroacetamides for the convenient introduction of trifluoroethyl groups into organic molecules. AU - Paradies, Jan AU - Köring, Laura AU - Sitte, Nikolai A. ID - 35686 IS - 05 JF - Synthesis KW - Organic Chemistry KW - Catalysis SN - 0039-7881 TI - Towards the Development of Frustrated Lewis Pair (FLP) Catalyzed Hydrogenations of Tertiary and Secondary Carboxylic Amides VL - 54 ER - TY - JOUR AU - Zhou, Rundong AU - Paradies, Jan ID - 35687 IS - 46 JF - European Journal of Organic Chemistry KW - Organic Chemistry KW - Physical and Theoretical Chemistry SN - 1434-193X TI - Borane Catalyzed Redox Isomerization of 2‐Amino Chalcones: Hydride Abstraction or Hydride Migration? VL - 2021 ER - TY - JOUR AU - Wicker, Garrit AU - Schoch, Roland AU - Paradies, Jan ID - 22232 JF - Organic Letters SN - 1523-7060 TI - Diastereoselective Synthesis of Dihydro-quinolin-4-ones by a Borane-Catalyzed Redox-Neutral endo-1,7-Hydride Shift ER -