TY - JOUR
AB - AbstractThe facile synthesis of highly functionalized building blocks with potential biological activity is of great interest to medicinal chemistry. The benzoxepinone core structures commonly exhibit biological activity. Thus, a short and efficient synthetic route towards benzoxepine containing scaffold, which enables late stage modification was developed. Namely, base-free catalytic Wittig reactions enabled the synthesis of bromobenzoxepinones from readily available starting materials. Subsequent, Suzuki–Miyaura and Stille reactions proved to be suitable methods to access a variety of benzoxepinone diaryl derivatives by late stage modification in only three steps. This three-step reaction sequence is suitable for high throughput applications and gives facile access to highly complex molecular structures, which are suitable for further functionalization. The antiproliferative properties of selected arylbenzoxepinones were tested in vitro on monolayer tumor cell line A549. Notably, in this initial screening, these compounds were found to be active in the micromolar range.
AU - Werner, Thomas
AU - Grandane, Aiga
AU - Pudnika, Linda
AU - Domraceva, Ilona
AU - Zalubovskis, Raivis
ID - 37946
IS - 19
JF - Synthesis
KW - Organic Chemistry
KW - Catalysis
SN - 0039-7881
TI - Base-Free Catalytic Wittig-/Cross-Coupling Reaction Sequence as Short Synthetic Strategy for the Preparation of Highly Functionalized Arylbenzoxepinones
VL - 53
ER -
TY - JOUR
AU - Paradies, Jan
AU - Andexer, Jennifer
AU - Beifuss, Uwe
AU - Beuerle, Florian
AU - Brasholz, Malte
AU - Breinbauer, Rolf
AU - Ernst, Martin
AU - Ganardi, Ruth
AU - Gulder, Tobias A. M.
AU - Hüttel, Wolfgang
AU - Kath‐Schorr, Stephanie
AU - Körber, Karsten
AU - Kordes, Markus
AU - Lehmann, Matthias
AU - Lindel, Thomas
AU - Luy, Burkhard
AU - Mück‐Lichtenfeld, Christian
AU - Muhle‐Goll, Claudia
AU - Niemeyer, Jochen
AU - Pfau, Roland
AU - Pietruszka, Jörg
AU - Röckl, Johannes L.
AU - Schaschke, Norbert
AU - Senge, Mathias O.
AU - Straub, Bernd F.
AU - Waldvogel, Siegfried R.
AU - Werner, Thomas
AU - Werz, Daniel B.
AU - Winter, Christian
ID - 37947
IS - 3
JF - Nachrichten aus der Chemie
KW - General Chemical Engineering
KW - General Chemistry
SN - 1439-9598
TI - Organische Chemie
VL - 69
ER -
TY - JOUR
AB -
A Mn–PNP complex proved to be a suitable catalyst for the transfer hydrogenation of amides, carbamates, urea derivatives and even polyurethanes.
AU - Liu, Xin
AU - Werner, Thomas
ID - 37944
IS - 31
JF - Chemical Science
KW - General Chemistry
SN - 2041-6520
TI - Indirect reduction of CO2 and recycling of polymers by manganese-catalyzed transfer hydrogenation of amides, carbamates, urea derivatives, and polyurethanes
VL - 12
ER -
TY - JOUR
AB - PMHS proved to be a suitable terminal reductant for P(iii)/P(v) redox cycling with a methyl-substituted phosphetane as catalyst and BuOAc as solvent. The formation of water by silanol condensation was identified as main pathway of siloxane formation.
AU - Tönjes, Jan
AU - Longwitz, Lars
AU - Werner, Thomas
ID - 37945
IS - 13
JF - Green Chemistry
KW - Pollution
KW - Environmental Chemistry
SN - 1463-9262
TI - Poly(methylhydrosiloxane) as a reductant in the catalytic base-free Wittig reaction
VL - 23
ER -
TY - CONF
AU - Dahm, Stephan
AU - Weigelt, Matthias
AU - Rieger, M.
ID - 38080
TI - Representations after mentally practiced one finger sequences are effector independent
ER -
TY - JOUR
AU - Wirth, Marisa A.
AU - Longwitz, Lars
AU - Kanwischer, Marion
AU - Gros, Peter
AU - Leinweber, Peter
AU - Werner, Thomas
ID - 37943
JF - Ecotoxicology and Environmental Safety
KW - Health
KW - Toxicology and Mutagenesis
KW - Public Health
KW - Environmental and Occupational Health
KW - Pollution
KW - General Medicine
SN - 0147-6513
TI - AMPA-15N – Synthesis and application as standard compound in traceable degradation studies of glyphosate
VL - 225
ER -
TY - CONF
AU - Budde, Kirsten
AU - Barela, J.A.
AU - Figueiredo, G.A.
AU - Weigelt, Matthias
ID - 38082
TI - Mental body rotation with egocentric and object-based transformations in different postures: sitting vs. standing
ER -
TY - JOUR
AB - AbstractThe development of the frustrated Lewis pair catalyzed hydrogenation of tertiary and secondary amides is reviewed. Detailed insight into our strategies in order to overcome challenges during the reaction development process is provided. Furthermore, the developed chemistry is extended to the hydrogenation of polyamides and of trifluoroacetamides for the convenient introduction of trifluoroethyl groups into organic molecules.
AU - Paradies, Jan
AU - Köring, Laura
AU - Sitte, Nikolai A.
ID - 35686
IS - 05
JF - Synthesis
KW - Organic Chemistry
KW - Catalysis
SN - 0039-7881
TI - Towards the Development of Frustrated Lewis Pair (FLP) Catalyzed Hydrogenations of Tertiary and Secondary Carboxylic Amides
VL - 54
ER -
TY - JOUR
AU - Zhou, Rundong
AU - Paradies, Jan
ID - 35687
IS - 46
JF - European Journal of Organic Chemistry
KW - Organic Chemistry
KW - Physical and Theoretical Chemistry
SN - 1434-193X
TI - Borane Catalyzed Redox Isomerization of 2‐Amino Chalcones: Hydride Abstraction or Hydride Migration?
VL - 2021
ER -
TY - JOUR
AU - Wicker, Garrit
AU - Schoch, Roland
AU - Paradies, Jan
ID - 22232
JF - Organic Letters
SN - 1523-7060
TI - Diastereoselective Synthesis of Dihydro-quinolin-4-ones by a Borane-Catalyzed Redox-Neutral endo-1,7-Hydride Shift
ER -