TY - JOUR
AB - There is a distinct increase in the prevalence of depression with the onset of puberty. The role of peripubertal testosterone levels in boys in this context is insufficiently understood and may be modulated by a functional polymorphism of the androgen receptor gene (AR), a variable number of CAG repeats. Moreover, there is preliminary evidence that the relationship between testosterone, CAG repeat length, and the severity of depressive symptoms may differ between subclinical and overt depression, but this has neither been studied in a clinical sample of adolescents with depression nor compared between subclinical and overt depression in an adequately powered study. To investigate the relationship between free testosterone, CAG repeat length of the AR, depression status (subclinical vs. overt), and the severity of depressive symptoms, 118 boys treated as in- or daycare patients at a single psychiatric hospital were studied. Of these, 73 boys had at least mild depressive symptoms according to the Beck Depression Inventory-II (BDI-II > 13). Higher-order moderation analysis in the multiple regression framework revealed a constant relationship between free testosterone and depression severity irrespective of the number of CAG repeats in adolescents with a BDI-II score ≤ 13. In adolescents with a BDI-II score > 13, however, there was a significant negative relationship between free testosterone and BDI-II score in patients with <19 CAG repeats and a significant positive relationship regarding free testosterone and BDI-II score in those with more than 28 CAG repeats, even when considering important covariates. These results suggest that the effects of testosterone on mood in male adolescents with depression depend on the genetic make-up of the AR as well as on depression status. This complex relationship should be considered by future studies addressing mental health issues against an endocrine background and may, moreover, contribute to tailored treatment concepts in psychiatric medicine, especially in adults.
AU - Hirtz, Raphael
AU - Libuda, Lars
AU - Hinney, Anke
AU - Föcker, Manuel
AU - Bühlmeier, Judith
AU - Holterhus, Paul-Martin
AU - Kulle, Alexandra
AU - Kiewert, Cordula
AU - Hebebrand, Johannes
AU - Grasemann, Corinna
ID - 27575
JF - Frontiers in Psychiatry
SN - 1664-0640
TI - Size Matters: The CAG Repeat Length of the Androgen Receptor Gene, Testosterone, and Male Adolescent Depression Severity
ER -
TY - JOUR
AB - (1) Background: Evidence has accumulated that patients with anorexia nervosa (AN) are at higher risk for vitamin D deficiency than healthy controls. In epidemiologic studies, low 25(OH) vitamin D (25(OH)D) levels were associated with depression. This study analyzed the relationship between 25(OH)D serum levels in adolescent patients and AN and depressive symptoms over the course of treatment. (2) Methods: 25(OH)D levels and depressive symptoms were analyzed in 93 adolescent (in-)patients with AN from the Anorexia Nervosa Day patient versus Inpatient (ANDI) multicenter trial at clinic admission, discharge, and 1 year follow up. Mixed regression models were used to analyze the relationship between 25(OH)D levels and depressive symptoms assessed by the Beck Depression Inventory (BDI-II). (3) Results: Although mean 25(OH)D levels constantly remained in recommended ranges (≥50 nmol/L) during AN treatment, levels decreased from (in)patient admission to 1 year follow up. Levels of 25(OH)D were neither cross-sectionally, prospectively, nor longitudinally associated with the BDI-II score. (4) Conclusions: This study did not confirm that 25(OH)D levels are associated with depressive symptoms in patients with AN. However, increasing risks of vitamin D deficiency over the course of AN treatment indicate that clinicians should monitor 25(OH)D levels.
AU - Föcker, Manuel
AU - Timmesfeld, Nina
AU - Bühlmeier, Judith
AU - Zwanziger, Denise
AU - Führer, Dagmar
AU - Grasemann, Corinna
AU - Ehrlich, Stefan
AU - Egberts, Karin
AU - Fleischhaker, Christian
AU - Wewetzer, Christoph
AU - Wessing, Ida
AU - Seitz, Jochen
AU - Herpertz-Dahlmann, Beate
AU - Hebebrand, Johannes
AU - Libuda, Lars
ID - 27571
JF - Nutrients
SN - 2072-6643
TI - Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms
ER -
TY - JOUR
AB - AbstractAnorexia nervosa (AN) is a severe eating disorder and often associated with altered humoral immune responses. However, distinct B cell maturation stages in peripheral blood in adolescents with AN have not been characterized. Treatment effects and the relationship between clinical and B cell parameters are also not fully understood. Here we investigated the phenotype of circulating B cell subsets and the relationship with body composition in adolescents with AN before (T0, n = 24) and after 6 weeks (T1, n = 20) of treatment. Using multi-parameter flow cytometry, we found increased percentages of antigen-experienced B cells and plasmablasts in patients with AN compared to healthy controls (n = 20). In contrast, percentages of CD1d+CD5+ B cells and transitional B cells with immunoregulatory roles were reduced at T0 and T1. These B cell frequencies correlated positively with fat mass, fat mass index (FMI), free fat mass index, and body mass index standard deviation score. In addition, scavenger-like receptor CD5 expression levels were downregulated on transitional B cells and correlated with fat mass and FMI in AN. Our findings that regulatory B cell subgroups were reduced in AN and their strong relationship with body composition parameters point toward an impact of immunoregulatory B cells in the pathogenesis of AN.
AU - Freff, Jana
AU - Schwarte, Kathrin
AU - Bröker, Lisa
AU - Bühlmeier, Judith
AU - Kraft, Isabelle
AU - Öztürk, Dana
AU - Hinney, Anke
AU - Arolt, Volker
AU - Dannlowski, Udo
AU - Romer, Georg
AU - Baune, Bernhard T.
AU - Hebebrand, Johannes
AU - Föcker, Manuel
AU - Alferink, Judith
ID - 26632
JF - Scientific Reports
SN - 2045-2322
TI - Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa
ER -
TY - JOUR
AU - Hebebrand, Johannes
AU - Antel, Jochen
AU - Tan, Susanne
AU - Wabitsch, Martin
AU - Wiesing, Urban
AU - Barth, Nikolaus
AU - Ludwig, Christine
AU - Bühlmeier, Judith
AU - Libuda, Lars
AU - Milos, Gabriella
AU - Hinney, Anke
ID - 26525
JF - Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie
SN - 1422-4917
TI - Kurzzeitige Behandlung von Patient_innen mit Anorexia nervosa mit rekombinant hergestelltem Human-Leptin (Metreleptin): Rasch einsetzende positive Effekte auf Stimmung, Kognition und Verhalten
ER -
TY - JOUR
AU - Kißling, Magdalena
ID - 33410
JF - Der Deutschunterrich (2)
TI - Vom ‚Komaglotzen‘ zum literar- und medienästhetischen Lernen. Konzeptualisierung eines fernsehseriellen Lehr-Lern-Settings am Beispiel des Teen Dramas ANNE WITH AN E.
ER -
TY - CHAP
AU - Kißling, Magdalena
ED - Dembeck, Till
ED - Pavlik, Jennifer
ID - 33419
T2 - Medienwissenschaften und Mediendidaktik im Dialog – Zum Status Quo von Medienbildung im Deutschunterricht
TI - Intermedialer Literaturunterricht. Ein medienintegratives Differenzierungskonzept zur Förderung literarästhetischen Lernens am Beispiel ausgewählter Kinderromane für die Sekundarstufe I
ER -
TY - CHAP
AU - Kißling, Magdalena
ID - 33420
T2 - Kinder- und Jugendliteratur intermedial. Unterrichtsanregungen und -materialien zum literarischen Lernen im Medienverbund anhand von Emil und die Detektive (Gym/Ge) und Jakob der Lügner (BK). Erstellt von Masterstudierenden der Universität Paderborn
TI - Einleitung
ER -
TY - CHAP
AU - Öhlschläger, Claudia
AU - Schneider, Martin
ED - Steigerwald, Jörn
ID - 32898
T2 - Komparatistik heute. Aktuelle Positionen der Vergleichenden Literatur- und Kulturwissenschaft
TI - Passivität als Widerstand gegen die Macht der Verhältnisse? "Bartleby, the scrivener" aus literaturwissenschaftlicher und ökonomischer Perspektive
ER -
TY - CHAP
AU - Knickenberg, Margarita
AU - Stöcker, A
AU - Zurbriggen, Carmen
ED - Resch, K
ED - Lindner, K.-T.
ED - Streese, B
ED - Proyer, M
ED - Schwab, S
ID - 33433
T2 - Inklusive Schule und Schulentwicklung Theoretische Grundlagen, empirische Befunde und Praxisbeispiele aus Deutschland, Österreich und der Schweiz.
TI - Inklusives Klassenklima. Zur Bedeutung der sozialen Dimension des Klassenklimas unter Berücksichtigung von Heterogenität
ER -
TY - CHAP
AU - Knickenberg, Margarita
AU - Zurbriggen, Carmen
ED - Hagenauer, G
ED - Raufelder, D
ID - 33434
T2 - G. Hagenauer & D. Raufelder (Hrsg.), Soziale Eingebundenheit. Sozialbeziehungen im Fokus von Schule und Lehrer*innenbildung
TI - Die Bedeutsamkeit von Peers für Jugendliche in der Sekundarstufe und in der Freizeit
ER -
TY - JOUR
AU - Martin, A.
AU - Herzig, Bardo
ID - 33465
IS - 1
JF - Pädagogik Unterricht: Die Fachzeitschrift für die pädagogische Fächergruppe
TI - Pädagogikunterricht und Digitalisierung: fachliches Lernen digital und digitales Lernen fachlich denken
ER -
TY - BOOK
AU - Tulodziecki, G.
AU - Herzig, Bardo
AU - Grafe, S.
ID - 33464
SN - 978-3-825-257460
TI - Medienbildung in Schule und Unterricht
ER -
TY - JOUR
AU - Herzig, Bardo
ID - 33462
IS - 23
JF - SchulVerwaltung spezial
TI - Wie wirksam ist das Lernen mit digitalen Medien? Einblicke in den Stand der Forschung
ER -
TY - GEN
AU - Bothe, Mike
AU - Lutters, Nicole
AU - Kenig, Eugeny Y.
ID - 28212
TI - Examination of hazardous situations in industrial closed-loop processes using dynamic simulations
ER -
TY - GEN
AU - Bothe, Mike
AU - Lutters, Nicole
AU - Kenig, Eugeny Y.
ID - 22461
TI - Dynamic simulation of hazardous situations in industrial closed loop processes considering chemical absorption
ER -
TY - CONF
AU - Markewitz, Friedrich
ED - Hünecke, Rainer
ID - 32701
T2 - Intertextualität. Vom Zitat zur Anspielung in Texten der deutschen Sprache vom 8. bis zum 19. Jahrhundert
TI - Die Bedeutung von Intertextualität für die Beschreibung der historischen Textsorte Schulprogramm. Zu Text-Text- sowie Text-Textwelt-Beziehungen
ER -
TY - JOUR
AU - Glowania, M
AU - Lassmann, I
AU - Ulrich, Tanja
ID - 33314
IS - 2
JF - Praxis Sprache
TI - Umsetzbarkeit des Wortschatzsammler-Therapiekonzepts bei Kindern mit Trisomie 21. Eine qualitative Einzelfallstudie
VL - 66
ER -
TY - JOUR
AU - Ulrich, Tanja
AU - Thater, S
AU - Mennicken, S
ID - 33313
IS - 2
JF - Logos
TI - Kasusfähigkeiten mehrsprachiger Achtjähriger. Eine explorative Pilotstudie in Regelgrundschulen
VL - 29
ER -
TY - JOUR
AB - While 2D Gibbsian particle systems might exhibit orientational order resulting in a lattice-like structure, these particle systems do not exhibit positional order if the interaction between particles satisfies some weak assumptions. Here we investigate to which extent particles within a box of size may fluctuate from their ideal lattice position. We show that particles near the center of the box typically show a displacement at least of order . Thus we extend recent results on the hard disk model to particle systems with fairly arbitrary particle spins and interaction. Our result applies to models such as rather general continuum Potts type models, e.g. with Widom–Rowlinson or Lenard-Jones-type interaction.
AU - Richthammer, Thomas
AU - Fiedler, Michael
ID - 33481
JF - Stochastic Processes and their Applications
TI - A lower bound on the displacement of particles in 2D Gibbsian particle systems
VL - 132
ER -
TY - GEN
AB - Consider a set of jobs connected to a directed acyclic task graph with a
fixed source and sink. The edges of this graph model precedence constraints and
the jobs have to be scheduled with respect to those. We introduce the Server
Cloud Scheduling problem, in which the jobs have to be processed either on a
single local machine or on one of many cloud machines. Both the source and the
sink have to be scheduled on the local machine. For each job, processing times
both on the server and in the cloud are given. Furthermore, for each edge in
the task graph, a communication delay is included in the input and has to be
taken into account if one of the two jobs is scheduled on the server, the other
in the cloud. The server can process jobs sequentially, whereas the cloud can
serve as many as needed in parallel, but induces costs. We consider both
makespan and cost minimization. The main results are an FPTAS with respect for
the makespan objective for a fairly general case and strong hardness for the
case with unit processing times and delays.
AU - Maack, Marten
AU - Meyer auf der Heide, Friedhelm
AU - Pukrop, Simon
ID - 27778
T2 - arXiv:2108.02109
TI - Full Version -- Server Cloud Scheduling
ER -