TY - JOUR AB - There is a distinct increase in the prevalence of depression with the onset of puberty. The role of peripubertal testosterone levels in boys in this context is insufficiently understood and may be modulated by a functional polymorphism of the androgen receptor gene (AR), a variable number of CAG repeats. Moreover, there is preliminary evidence that the relationship between testosterone, CAG repeat length, and the severity of depressive symptoms may differ between subclinical and overt depression, but this has neither been studied in a clinical sample of adolescents with depression nor compared between subclinical and overt depression in an adequately powered study. To investigate the relationship between free testosterone, CAG repeat length of the AR, depression status (subclinical vs. overt), and the severity of depressive symptoms, 118 boys treated as in- or daycare patients at a single psychiatric hospital were studied. Of these, 73 boys had at least mild depressive symptoms according to the Beck Depression Inventory-II (BDI-II > 13). Higher-order moderation analysis in the multiple regression framework revealed a constant relationship between free testosterone and depression severity irrespective of the number of CAG repeats in adolescents with a BDI-II score ≤ 13. In adolescents with a BDI-II score > 13, however, there was a significant negative relationship between free testosterone and BDI-II score in patients with <19 CAG repeats and a significant positive relationship regarding free testosterone and BDI-II score in those with more than 28 CAG repeats, even when considering important covariates. These results suggest that the effects of testosterone on mood in male adolescents with depression depend on the genetic make-up of the AR as well as on depression status. This complex relationship should be considered by future studies addressing mental health issues against an endocrine background and may, moreover, contribute to tailored treatment concepts in psychiatric medicine, especially in adults. AU - Hirtz, Raphael AU - Libuda, Lars AU - Hinney, Anke AU - Föcker, Manuel AU - Bühlmeier, Judith AU - Holterhus, Paul-Martin AU - Kulle, Alexandra AU - Kiewert, Cordula AU - Hebebrand, Johannes AU - Grasemann, Corinna ID - 27575 JF - Frontiers in Psychiatry SN - 1664-0640 TI - Size Matters: The CAG Repeat Length of the Androgen Receptor Gene, Testosterone, and Male Adolescent Depression Severity ER - TY - JOUR AB - (1) Background: Evidence has accumulated that patients with anorexia nervosa (AN) are at higher risk for vitamin D deficiency than healthy controls. In epidemiologic studies, low 25(OH) vitamin D (25(OH)D) levels were associated with depression. This study analyzed the relationship between 25(OH)D serum levels in adolescent patients and AN and depressive symptoms over the course of treatment. (2) Methods: 25(OH)D levels and depressive symptoms were analyzed in 93 adolescent (in-)patients with AN from the Anorexia Nervosa Day patient versus Inpatient (ANDI) multicenter trial at clinic admission, discharge, and 1 year follow up. Mixed regression models were used to analyze the relationship between 25(OH)D levels and depressive symptoms assessed by the Beck Depression Inventory (BDI-II). (3) Results: Although mean 25(OH)D levels constantly remained in recommended ranges (≥50 nmol/L) during AN treatment, levels decreased from (in)patient admission to 1 year follow up. Levels of 25(OH)D were neither cross-sectionally, prospectively, nor longitudinally associated with the BDI-II score. (4) Conclusions: This study did not confirm that 25(OH)D levels are associated with depressive symptoms in patients with AN. However, increasing risks of vitamin D deficiency over the course of AN treatment indicate that clinicians should monitor 25(OH)D levels. AU - Föcker, Manuel AU - Timmesfeld, Nina AU - Bühlmeier, Judith AU - Zwanziger, Denise AU - Führer, Dagmar AU - Grasemann, Corinna AU - Ehrlich, Stefan AU - Egberts, Karin AU - Fleischhaker, Christian AU - Wewetzer, Christoph AU - Wessing, Ida AU - Seitz, Jochen AU - Herpertz-Dahlmann, Beate AU - Hebebrand, Johannes AU - Libuda, Lars ID - 27571 JF - Nutrients SN - 2072-6643 TI - Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms ER - TY - JOUR AB - AbstractAnorexia nervosa (AN) is a severe eating disorder and often associated with altered humoral immune responses. However, distinct B cell maturation stages in peripheral blood in adolescents with AN have not been characterized. Treatment effects and the relationship between clinical and B cell parameters are also not fully understood. Here we investigated the phenotype of circulating B cell subsets and the relationship with body composition in adolescents with AN before (T0, n = 24) and after 6 weeks (T1, n = 20) of treatment. Using multi-parameter flow cytometry, we found increased percentages of antigen-experienced B cells and plasmablasts in patients with AN compared to healthy controls (n = 20). In contrast, percentages of CD1d+CD5+ B cells and transitional B cells with immunoregulatory roles were reduced at T0 and T1. These B cell frequencies correlated positively with fat mass, fat mass index (FMI), free fat mass index, and body mass index standard deviation score. In addition, scavenger-like receptor CD5 expression levels were downregulated on transitional B cells and correlated with fat mass and FMI in AN. Our findings that regulatory B cell subgroups were reduced in AN and their strong relationship with body composition parameters point toward an impact of immunoregulatory B cells in the pathogenesis of AN. AU - Freff, Jana AU - Schwarte, Kathrin AU - Bröker, Lisa AU - Bühlmeier, Judith AU - Kraft, Isabelle AU - Öztürk, Dana AU - Hinney, Anke AU - Arolt, Volker AU - Dannlowski, Udo AU - Romer, Georg AU - Baune, Bernhard T. AU - Hebebrand, Johannes AU - Föcker, Manuel AU - Alferink, Judith ID - 26632 JF - Scientific Reports SN - 2045-2322 TI - Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa ER - TY - JOUR AU - Hebebrand, Johannes AU - Antel, Jochen AU - Tan, Susanne AU - Wabitsch, Martin AU - Wiesing, Urban AU - Barth, Nikolaus AU - Ludwig, Christine AU - Bühlmeier, Judith AU - Libuda, Lars AU - Milos, Gabriella AU - Hinney, Anke ID - 26525 JF - Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie SN - 1422-4917 TI - Kurzzeitige Behandlung von Patient_innen mit Anorexia nervosa mit rekombinant hergestelltem Human-Leptin (Metreleptin): Rasch einsetzende positive Effekte auf Stimmung, Kognition und Verhalten ER - TY - JOUR AU - Kißling, Magdalena ID - 33410 JF - Der Deutschunterrich (2) TI - Vom ‚Komaglotzen‘ zum literar- und medienästhetischen Lernen. Konzeptualisierung eines fernsehseriellen Lehr-Lern-Settings am Beispiel des Teen Dramas ANNE WITH AN E. ER - TY - CHAP AU - Kißling, Magdalena ED - Dembeck, Till ED - Pavlik, Jennifer ID - 33419 T2 - Medienwissenschaften und Mediendidaktik im Dialog – Zum Status Quo von Medienbildung im Deutschunterricht TI - Intermedialer Literaturunterricht. Ein medienintegratives Differenzierungskonzept zur Förderung literarästhetischen Lernens am Beispiel ausgewählter Kinderromane für die Sekundarstufe I ER - TY - CHAP AU - Kißling, Magdalena ID - 33420 T2 - Kinder- und Jugendliteratur intermedial. Unterrichtsanregungen und -materialien zum literarischen Lernen im Medienverbund anhand von Emil und die Detektive (Gym/Ge) und Jakob der Lügner (BK). Erstellt von Masterstudierenden der Universität Paderborn TI - Einleitung ER - TY - CHAP AU - Öhlschläger, Claudia AU - Schneider, Martin ED - Steigerwald, Jörn ID - 32898 T2 - Komparatistik heute. Aktuelle Positionen der Vergleichenden Literatur- und Kulturwissenschaft TI - Passivität als Widerstand gegen die Macht der Verhältnisse? "Bartleby, the scrivener" aus literaturwissenschaftlicher und ökonomischer Perspektive ER - TY - CHAP AU - Knickenberg, Margarita AU - Stöcker, A AU - Zurbriggen, Carmen ED - Resch, K ED - Lindner, K.-T. ED - Streese, B ED - Proyer, M ED - Schwab, S ID - 33433 T2 - Inklusive Schule und Schulentwicklung Theoretische Grundlagen, empirische Befunde und Praxisbeispiele aus Deutschland, Österreich und der Schweiz. TI - Inklusives Klassenklima. Zur Bedeutung der sozialen Dimension des Klassenklimas unter Berücksichtigung von Heterogenität ER - TY - CHAP AU - Knickenberg, Margarita AU - Zurbriggen, Carmen ED - Hagenauer, G ED - Raufelder, D ID - 33434 T2 - G. Hagenauer & D. Raufelder (Hrsg.), Soziale Eingebundenheit. Sozialbeziehungen im Fokus von Schule und Lehrer*innenbildung TI - Die Bedeutsamkeit von Peers für Jugendliche in der Sekundarstufe und in der Freizeit ER - TY - JOUR AU - Martin, A. AU - Herzig, Bardo ID - 33465 IS - 1 JF - Pädagogik Unterricht: Die Fachzeitschrift für die pädagogische Fächergruppe TI - Pädagogikunterricht und Digitalisierung: fachliches Lernen digital und digitales Lernen fachlich denken ER - TY - BOOK AU - Tulodziecki, G. AU - Herzig, Bardo AU - Grafe, S. ID - 33464 SN - 978-3-825-257460 TI - Medienbildung in Schule und Unterricht ER - TY - JOUR AU - Herzig, Bardo ID - 33462 IS - 23 JF - SchulVerwaltung spezial TI - Wie wirksam ist das Lernen mit digitalen Medien? Einblicke in den Stand der Forschung ER - TY - GEN AU - Bothe, Mike AU - Lutters, Nicole AU - Kenig, Eugeny Y. ID - 28212 TI - Examination of hazardous situations in industrial closed-loop processes using dynamic simulations ER - TY - GEN AU - Bothe, Mike AU - Lutters, Nicole AU - Kenig, Eugeny Y. ID - 22461 TI - Dynamic simulation of hazardous situations in industrial closed loop processes considering chemical absorption ER - TY - CONF AU - Markewitz, Friedrich ED - Hünecke, Rainer ID - 32701 T2 - Intertextualität. Vom Zitat zur Anspielung in Texten der deutschen Sprache vom 8. bis zum 19. Jahrhundert TI - Die Bedeutung von Intertextualität für die Beschreibung der historischen Textsorte Schulprogramm. Zu Text-Text- sowie Text-Textwelt-Beziehungen ER - TY - JOUR AU - Glowania, M AU - Lassmann, I AU - Ulrich, Tanja ID - 33314 IS - 2 JF - Praxis Sprache TI - Umsetzbarkeit des Wortschatzsammler-Therapiekonzepts bei Kindern mit Trisomie 21. Eine qualitative Einzelfallstudie VL - 66 ER - TY - JOUR AU - Ulrich, Tanja AU - Thater, S AU - Mennicken, S ID - 33313 IS - 2 JF - Logos TI - Kasusfähigkeiten mehrsprachiger Achtjähriger. Eine explorative Pilotstudie in Regelgrundschulen VL - 29 ER - TY - JOUR AB - While 2D Gibbsian particle systems might exhibit orientational order resulting in a lattice-like structure, these particle systems do not exhibit positional order if the interaction between particles satisfies some weak assumptions. Here we investigate to which extent particles within a box of size may fluctuate from their ideal lattice position. We show that particles near the center of the box typically show a displacement at least of order . Thus we extend recent results on the hard disk model to particle systems with fairly arbitrary particle spins and interaction. Our result applies to models such as rather general continuum Potts type models, e.g. with Widom–Rowlinson or Lenard-Jones-type interaction. AU - Richthammer, Thomas AU - Fiedler, Michael ID - 33481 JF - Stochastic Processes and their Applications TI - A lower bound on the displacement of particles in 2D Gibbsian particle systems VL - 132 ER - TY - GEN AB - Consider a set of jobs connected to a directed acyclic task graph with a fixed source and sink. The edges of this graph model precedence constraints and the jobs have to be scheduled with respect to those. We introduce the Server Cloud Scheduling problem, in which the jobs have to be processed either on a single local machine or on one of many cloud machines. Both the source and the sink have to be scheduled on the local machine. For each job, processing times both on the server and in the cloud are given. Furthermore, for each edge in the task graph, a communication delay is included in the input and has to be taken into account if one of the two jobs is scheduled on the server, the other in the cloud. The server can process jobs sequentially, whereas the cloud can serve as many as needed in parallel, but induces costs. We consider both makespan and cost minimization. The main results are an FPTAS with respect for the makespan objective for a fairly general case and strong hardness for the case with unit processing times and delays. AU - Maack, Marten AU - Meyer auf der Heide, Friedhelm AU - Pukrop, Simon ID - 27778 T2 - arXiv:2108.02109 TI - Full Version -- Server Cloud Scheduling ER -