TY - CHAP AU - Lorenz, Ramona AU - Endberg, Manuela AU - Eickelmann, Birgit ED - Ehmke, Timo ED - Kuhl, Poldi ED - Pietsch, Marcus ID - 28791 T2 - Lehrer. Bildung. Gestalten. Beiträge zur empirischen Forschung in der Lehrerbildung TI - Medienbezogene Kompetenzen von Lehrpersonen – Empirische Befunde und Perspektiven für die Lehrerausbildung ER - TY - CHAP AU - Drossel, Kerstin AU - Eickelmann, Birgit ED - Ehmke, Timo ED - Kuhl, Poldi ED - Pietsch, Marcus ID - 28792 T2 - Lehrer. Bildung. Gestalten. Beiträge zur empirischen Forschung in der Lehrerbildung TI - Die Implementation digitaler Medien gestalten: zur Bedeutung der Einstellungen von Fremdsprachenlehrkräften ER - TY - CHAP AU - Vennemann, Mario AU - Schwippert, Knut AU - Eickelmann, Birgit AU - Massek, Corinna ED - Eickelmann, Birgit ED - Bos, Wilfried ED - Gerick, Julia ED - Goldhammer, Frank ED - Schaumburg, Heike ED - Schwippert, Knut ED - Senkbeil, Martin ED - Vahrenhold, Jan ID - 28795 T2 - ICILS 2018 #Deutschland – Computer- und informationsbezogene Kompetenzen von Schülerinnen und Schülern im zweiten internationalen Vergleich und Kompetenzen im Bereich Computational Thinking TI - Computer- und informationsbezogene Kompetenzen von Schülerinnen und Schülern mit und ohne Migrationshintergrund im zweiten internationalen Vergleich ER - TY - CHAP AU - Senkbeil, Martin AU - Drossel, Kerstin AU - Eickelmann, Birgit AU - Vennemann, Mario ED - Eickelmann, Birgit ED - Bos, Wilfried ED - Gerick, Julia ED - Goldhammer, Frank ED - Schaumburg, Heike ED - Schwippert, Knut ED - Senkbeil, Martin ED - Vahrenhold, Jan ID - 28797 T2 - ICILS 2018 #Deutschland – Computer- und informationsbezogene Kompetenzen von Schülerinnen und Schülern im zweiten internationalen Vergleich und Kompetenzen im Bereich Computational Thinking TI - Soziale Herkunft und computer- und informationsbezogene Kompetenzen von Schülerinnen und Schülern im zweiten internationalen Vergleich ER - TY - CHAP AU - Gerick, Julia AU - Massek, Corinna AU - Eickelmann, Birgit AU - Labusch, Amelie ED - Eickelmann, Birgit ED - Bos, Wilfried ED - Gerick, Julia ED - Goldhammer, Frank ED - Schaumburg, Heike ED - Schwippert, Knut ED - Senkbeil, Martin ED - Vahrenhold, Jan ID - 28799 T2 - ICILS 2018 #Deutschland – Computer- und informationsbezogene Kompetenzen von Schülerinnen und Schülern im zweiten internationalen Vergleich und Kompetenzen im Bereich Computational Thinking TI - Computer- und informationsbezogene Kompetenzen von Mädchen und Jungen im zweiten internationalen Vergleich ER - TY - CHAP AU - Eickelmann, Birgit AU - Bos, Wilfried AU - Gerick, Julia AU - Goldhammer, Frank AU - Schaumburg, Heike AU - Schwippert, Knut AU - Senkbeil, Martin AU - Vahrenhold, Jan ED - Eickelmann, Birgit ED - Bos, Wilfried ED - Gerick, Julia ED - Goldhammer, Frank ED - Schaumburg, Heike ED - Schwippert, Knut ED - Senkbeil, Martin ED - Vahrenhold, Jan ID - 28814 T2 - ICILS 2018 #Deutschland – Computer- und informationsbezogene Kompetenzen von Schülerinnen und Schülern im zweiten internationalen Vergleich und Kompetenzen im Bereich Computational Thinking TI - Anlage, Forschungsdesign und Durchführung der Studie ICILS 2018 ER - TY - BOOK ED - Eickelmann, Birgit ED - Bos, Wilfried ED - Gerick, Julia ED - Goldhammer, Frank ED - Schaumburg, Heike ED - Schwippert, Knut ED - Senkbeil, Martin ED - Vahrenhold, Jan ID - 28819 TI - ICILS 2018 #Deutschland – Computer- und informationsbezogene Kompetenzen von Schülerinnen und Schülern im zweiten internationalen Vergleich und Kompetenzen im Bereich Computational Thinking ER - TY - DATA AU - Gerick, Julia AU - Eickelmann, Birgit AU - Steglich, Emilie ID - 28826 TI - Kurzzusammenfassung der Ergebnisse der prozessbegleitenden wissenschaftlichen Evaluation der Einführung von LOGINEO NRW an Pilotschulen ER - TY - DATA AU - Gerick, Julia AU - Eickelmann, Birgit AU - Steglich, Emilie ID - 28828 TI - Abschlussbericht zur prozessbegleitenden Evaluation der Einführung von LOGINEO NRW an Pilotschulen ER - TY - CHAP AU - Eickelmann, Birgit ED - Priebe, Botho ED - Böttcher, Wolfgang ED - Heinemann, Ulrich ED - Kubina, Christian ID - 28830 T2 - Steuerung und Qualitätsentwicklung im Fortbildungssystem. Probleme und Befunde – Standardbildung und Lösungsansätze TI - Lehrerfortbildung im Kontext der digitalen Transformation: Herausforderungen, Befunde und Perspektiven für eine zukunftsfähige Gestaltung des Bildungssystems ER - TY - JOUR AU - Brauer, Sascha ID - 2916 JF - Theoretical Computer Science SN - 0304-3975 TI - Complexity of single-swap heuristics for metric facility location and related problems VL - 754 ER - TY - JOUR AU - Perrar, Ines AU - Schmitting, Sarah AU - Della Corte, Karen W. AU - Buyken, Anette AU - Alexy, Ute ID - 27003 JF - European Journal of Nutrition SN - 1436-6207 TI - Age and time trends in sugar intake among children and adolescents: results from the DONALD study ER - TY - JOUR AU - Wong, Tommy H. T. AU - Buyken, Anette AU - Brand-Miller, Jennie C. AU - Louie, Jimmy Chun Yu ID - 27004 JF - European Journal of Nutrition SN - 1436-6207 TI - Is there a soft drink vs. alcohol seesaw? A cross-sectional analysis of dietary data in the Australian Health Survey 2011–12 ER - TY - JOUR AB - ABSTRACT Background There is controversy on the relevance of dietary sugar intake for cardiometabolic health. Objective The aim of this network meta-analysis (NMA) was to assess how isocaloric substitutions of dietary sugar with other carbohydrates affect cardiometabolic risk factors, comparing different intervention studies. Methods We included randomized controlled trials (RCTs) investigating the isocaloric effect of substituting dietary sugars (fructose, glucose, sucrose) with other sugars or starch on cardiometabolic risk markers, including LDL cholesterol, triacylglycerol (TG), fasting glucose (FG), glycated hemoglobin (HbA1c), insulin resistance (HOMA-IR), uric acid, C-reactive protein (CRP), alanine transaminase (ALT), aspartate transaminase (AST), and liver fat content. To identify the most beneficial intervention for each outcome, random-effects NMA was conducted by calculating pooled mean differences (MDs) with 95% CIs, and by ranking the surface under the cumulative ranking curves (SUCRAs). The certainty of evidence was evaluated using the Confidence In Network Meta-Analysis tool. Results Thirty-eight RCTs, including 1383 participants, were identified. A reduction in LDL-cholesterol concentrations was shown for the exchange of sucrose with starch (MD: −0.23 mmol/L; 95% CI: −0.38, −0.07 mmol/L) or fructose with starch (MD: −0.22 mmol/L; 95% CI: −0.39, −0.05 mmol/L; SUCRAstarch: 98%). FG concentrations were also lower for the exchange of sucrose with starch (MD: −0.14 mmol/L; 95% CI: −0.29, 0.01 mmol/L; SUCRAstarch: 91%). Replacing fructose with an equivalent energy amount of glucose reduced HOMA-IR (MD: −0.36; 95% CI: −0.71, −0.02; SUCRAglucose: 74%) and uric acid (MD: −23.77 µmol/L; 95% CI: −44.21, −3.32 µmol/L; SUCRAglucose: 93%). The certainty of evidence was rated very low to moderate. No significant effects were observed for TG, HbA1c, CRP, ALT, and AST. Conclusions Our findings indicate that substitution of sucrose and fructose with starch yielded lower LDL cholesterol. Insulin resistance and uric acid concentrations were beneficially affected by replacement of fructose with glucose. Our findings are limited by the very low to moderate certainty of evidence. This review was registered at www.crd.york.ac.uk/prospero as CRD42018080297. AU - Schwingshackl, Lukas AU - Neuenschwander, Manuela AU - Hoffmann, Georg AU - Buyken, Anette AU - Schlesinger, Sabrina ID - 27005 JF - The American Journal of Clinical Nutrition SN - 0002-9165 TI - Dietary sugars and cardiometabolic risk factors: a network meta-analysis on isocaloric substitution interventions ER - TY - JOUR AB - Trend analyses suggest that free sugar (FS) intake—while still exceeding 10%E—has decreased among German children and adolescents since 2005, yet that intakes may shift from sugars naturally occurring in foods to added sugars as children age. Thus, we analysed time and age trends in FS intake (%E) from food groups among 3–18 year-olds (1985–2016) using 10,761 3-day dietary records from 1312 DONALD participants (660 boys, 652 girls) by use of polynomial mixed-effects regression models. Among girls, FS from sugar & sweets decreased from 1985 to 2016 (linear trend p < 0.0001), but not among boys (p > 0.05). In the total sample, FS intake from juices increased until 2000 and decreased since 2005 (linear, quadratic trend p < 0.0001). FS from sugar sweetened beverages (SSB) decreased non-linearly from 1985 to 2016 (girls: linear, quadratic, cubic trend p < 0.0001; boys: linear, quadratic, cubic trend p < 0.02). Younger children consumed more FS from juices than older ones, who had a higher FS intake from SSB. FS intake from sugar & sweets increased until early adolescence and decreased afterwards. Since sugar & sweets represent the main source of FS intake and the source with the least pronounced decline in intake, public health measures should focus on these products. AU - Perrar, Ines AU - Schadow, Alena M. AU - Schmitting, Sarah AU - Buyken, Anette AU - Alexy, Ute ID - 27006 JF - Nutrients SN - 2072-6643 TI - Time and Age Trends in Free Sugar Intake from Food Groups among Children and Adolescents between 1985 and 2016 ER - TY - JOUR AB - Abstract Background Blood immunoreactive biomarkers, such as C-reactive protein (CRP), and metabolic abnormalities have been associated with schizophrenia. Studies comprehensively and bidirectionally probing possible causal links between such blood constituents and liability to schizophrenia are lacking. Methods To disentangle putative causal links between CRP blood levels and schizophrenia in both directions, we conducted multiple univariable Mendelian-randomization (MR) analyses, ranging from fixed-effect to inverse variance-weighted (IVW), weighted-median, MR Egger and generalized summary-data-based Mendelian-randomization (GSMR) models. To prioritize metabolic risk factors for schizophrenia, a novel multivariable approach was applied: multivariable Mendelian-randomization–Bayesian model averaging (MR-BMA). Results All forward univariable MR analyses consistently showed that CRP has a protective effect on schizophrenia, whereas reverse MR analyses consistently suggested absent causal effects of schizophrenia liability on CRP blood levels. Using MR-BMA, as the top protective factors for schizophrenia we prioritized leucine and as the prime risk-factor triglycerides in medium very-low-density lipoprotein (VLDL). The five best-performing MR-BMA models provided one additional risk factor: triglycerides in large VLDL; and two additional protective factors: citrate and lactate. Conclusions Our results add to a growing body of literature hinting at metabolic changes—in particular of triglycerides—independently of medication status in schizophrenia. We also highlight the absent effects of genetic liability to schizophrenia on CRP levels. AU - Lin, Bochao D AU - Alkema, Anne AU - Peters, Triinu AU - Zinkstok, Janneke AU - Libuda, Lars AU - Hebebrand, Johannes AU - Antel, Jochen AU - Hinney, Anke AU - Cahn, Wiepke AU - Adan, Roger AU - Luykx, Jurjen J ID - 27023 JF - International Journal of Epidemiology SN - 0300-5771 TI - Assessing causal links between metabolic traits, inflammation and schizophrenia: a univariable and multivariable, bidirectional Mendelian-randomization study ER - TY - JOUR AU - Kalhoff, Hermann AU - Mesch, Christina M. AU - Stimming, Madlen AU - Israel, Andreas AU - Spitzer, Christoph AU - Beganovic, Latifa AU - Perez, Rocio Estella AU - Koletzko, Berthold AU - Warschburger, Petra AU - Kersting, Mathilde AU - Libuda, Lars ID - 27024 JF - European Journal of Clinical Nutrition SN - 0954-3007 TI - Effects of LC-PUFA supply via complementary food on infant development—a food based intervention (RCT) embedded in a total diet concept ER - TY - CONF AU - Drewel, Marvin AU - Gausemeier, Jürgen AU - Vaßholz, Mareen AU - Homburg, Nils ED - Gausemeier, Jürgen ED - Bauer, Wilhelm ED - Dumitrescu, Roman ID - 27101 T2 - Symposium für Vorausschau und Technologieplanung, Band 15 TI - Einstieg in die Plattformökonomie ER - TY - JOUR AB - Mithilfe von Industrie 4.0-Reifegradmodellen können Unternehmen ihren Leistungsstand im Kontext Industrie 4.0 systematisch erfassen. Mit der Ermittlung des Status Quos ist in aller Regel die Frage verbunden „Wo wollen wir zukünftig hin?“. Vor dem Hintergrund, dass Unternehmen aus unterschiedlichen Gründen nicht immer das grundsätzlich Mögliche einführen können, ist die Beantwortung dieser Frage nicht trivial. Ist sich ein Unternehmen über seine I4.0-Zielposition vermeintlich im Klaren, führen äußere Einflüsse häufig dazu, dass die Zielerreichung erschwert wird, was oftmals eine Anpassung der Zielposition zur Folge hat. Es gilt also, diese Umstände bereits in der Planung zu berücksichtigen. Der vorliegende Beitrag zeigt auf, wie Umfeldentwicklungen bei der Ermittlung einer Erfolg versprechenden I4.0-Zielposition von Unternehmen einbezogen werden können. AU - Pierenkemper, Christoph AU - Reinhold, Jannik AU - Dumitrescu, Roman AU - Gausemeier, Jürgen ID - 27102 JF - Industrie 4.0 Management (5) TI - Erfolg versprechende Industrie 4.0-Zielposition - Ermittlung unter Berücksichtigung zukünftiger Umfeldentwicklungen ER - TY - CONF AB - One of the notable drivers of the fourth industrial revolution is the collection of vast amounts of data along the entire lifecycle of a product. The analysis of product lifecycle data in conjunction with product hypotheses leads to promising potentials in strategic product planning. In this thesis paper, we postulate the need for data-driven product generation and retrofit planning as an interdisciplinary field of research. We define and analyze the key concepts and derive requirements in a structured way. Based on an exhaustive research of existing approaches, we structure open research questions and propose a roadmap in order to shape future research efforts. AU - Massmann, Melina AU - Meyer, Maurice AU - Dumitrescu, Roman AU - von Enzberg, Sebastian AU - Frank, Maximilian AU - Koldewey, Christian AU - Kühn, Arno AU - Reinhold, Jannik ID - 27103 T2 - Proceedings of the CIRP DESIGN TI - Significance and Challenges of Data-driven Product Generation and Retrofit Planning ER -