TY - JOUR
AB - AbstractThe facile synthesis of highly functionalized building blocks with potential biological activity is of great interest to medicinal chemistry. The benzoxepinone core structures commonly exhibit biological activity. Thus, a short and efficient synthetic route towards benzoxepine containing scaffold, which enables late stage modification was developed. Namely, base-free catalytic Wittig reactions enabled the synthesis of bromobenzoxepinones from readily available starting materials. Subsequent, Suzuki–Miyaura and Stille reactions proved to be suitable methods to access a variety of benzoxepinone diaryl derivatives by late stage modification in only three steps. This three-step reaction sequence is suitable for high throughput applications and gives facile access to highly complex molecular structures, which are suitable for further functionalization. The antiproliferative properties of selected arylbenzoxepinones were tested in vitro on monolayer tumor cell line A549. Notably, in this initial screening, these compounds were found to be active in the micromolar range.
AU - Werner, Thomas
AU - Grandane, Aiga
AU - Pudnika, Linda
AU - Domraceva, Ilona
AU - Zalubovskis, Raivis
ID - 37946
IS - 19
JF - Synthesis
KW - Organic Chemistry
KW - Catalysis
SN - 0039-7881
TI - Base-Free Catalytic Wittig-/Cross-Coupling Reaction Sequence as Short Synthetic Strategy for the Preparation of Highly Functionalized Arylbenzoxepinones
VL - 53
ER -
TY - JOUR
AU - Paradies, Jan
AU - Andexer, Jennifer
AU - Beifuss, Uwe
AU - Beuerle, Florian
AU - Brasholz, Malte
AU - Breinbauer, Rolf
AU - Ernst, Martin
AU - Ganardi, Ruth
AU - Gulder, Tobias A. M.
AU - Hüttel, Wolfgang
AU - Kath‐Schorr, Stephanie
AU - Körber, Karsten
AU - Kordes, Markus
AU - Lehmann, Matthias
AU - Lindel, Thomas
AU - Luy, Burkhard
AU - Mück‐Lichtenfeld, Christian
AU - Muhle‐Goll, Claudia
AU - Niemeyer, Jochen
AU - Pfau, Roland
AU - Pietruszka, Jörg
AU - Röckl, Johannes L.
AU - Schaschke, Norbert
AU - Senge, Mathias O.
AU - Straub, Bernd F.
AU - Waldvogel, Siegfried R.
AU - Werner, Thomas
AU - Werz, Daniel B.
AU - Winter, Christian
ID - 37947
IS - 3
JF - Nachrichten aus der Chemie
KW - General Chemical Engineering
KW - General Chemistry
SN - 1439-9598
TI - Organische Chemie
VL - 69
ER -
TY - JOUR
AB -
A Mn–PNP complex proved to be a suitable catalyst for the transfer hydrogenation of amides, carbamates, urea derivatives and even polyurethanes.
AU - Liu, Xin
AU - Werner, Thomas
ID - 37944
IS - 31
JF - Chemical Science
KW - General Chemistry
SN - 2041-6520
TI - Indirect reduction of CO2 and recycling of polymers by manganese-catalyzed transfer hydrogenation of amides, carbamates, urea derivatives, and polyurethanes
VL - 12
ER -
TY - JOUR
AB - PMHS proved to be a suitable terminal reductant for P(iii)/P(v) redox cycling with a methyl-substituted phosphetane as catalyst and BuOAc as solvent. The formation of water by silanol condensation was identified as main pathway of siloxane formation.
AU - Tönjes, Jan
AU - Longwitz, Lars
AU - Werner, Thomas
ID - 37945
IS - 13
JF - Green Chemistry
KW - Pollution
KW - Environmental Chemistry
SN - 1463-9262
TI - Poly(methylhydrosiloxane) as a reductant in the catalytic base-free Wittig reaction
VL - 23
ER -
TY - CONF
AU - Dahm, Stephan
AU - Weigelt, Matthias
AU - Rieger, M.
ID - 38080
TI - Representations after mentally practiced one finger sequences are effector independent
ER -
TY - JOUR
AU - Wirth, Marisa A.
AU - Longwitz, Lars
AU - Kanwischer, Marion
AU - Gros, Peter
AU - Leinweber, Peter
AU - Werner, Thomas
ID - 37943
JF - Ecotoxicology and Environmental Safety
KW - Health
KW - Toxicology and Mutagenesis
KW - Public Health
KW - Environmental and Occupational Health
KW - Pollution
KW - General Medicine
SN - 0147-6513
TI - AMPA-15N – Synthesis and application as standard compound in traceable degradation studies of glyphosate
VL - 225
ER -
TY - CONF
AU - Budde, Kirsten
AU - Barela, J.A.
AU - Figueiredo, G.A.
AU - Weigelt, Matthias
ID - 38082
TI - Mental body rotation with egocentric and object-based transformations in different postures: sitting vs. standing
ER -
TY - JOUR
AB - AbstractThe development of the frustrated Lewis pair catalyzed hydrogenation of tertiary and secondary amides is reviewed. Detailed insight into our strategies in order to overcome challenges during the reaction development process is provided. Furthermore, the developed chemistry is extended to the hydrogenation of polyamides and of trifluoroacetamides for the convenient introduction of trifluoroethyl groups into organic molecules.
AU - Paradies, Jan
AU - Köring, Laura
AU - Sitte, Nikolai A.
ID - 35686
IS - 05
JF - Synthesis
KW - Organic Chemistry
KW - Catalysis
SN - 0039-7881
TI - Towards the Development of Frustrated Lewis Pair (FLP) Catalyzed Hydrogenations of Tertiary and Secondary Carboxylic Amides
VL - 54
ER -
TY - JOUR
AU - Zhou, Rundong
AU - Paradies, Jan
ID - 35687
IS - 46
JF - European Journal of Organic Chemistry
KW - Organic Chemistry
KW - Physical and Theoretical Chemistry
SN - 1434-193X
TI - Borane Catalyzed Redox Isomerization of 2‐Amino Chalcones: Hydride Abstraction or Hydride Migration?
VL - 2021
ER -
TY - JOUR
AU - Wicker, Garrit
AU - Schoch, Roland
AU - Paradies, Jan
ID - 22232
JF - Organic Letters
SN - 1523-7060
TI - Diastereoselective Synthesis of Dihydro-quinolin-4-ones by a Borane-Catalyzed Redox-Neutral endo-1,7-Hydride Shift
ER -
TY - JOUR
AU - Köring, Laura
AU - Sitte, Nikolai A.
AU - Bursch, Markus
AU - Grimme, Stefan
AU - Paradies, Jan
ID - 22233
JF - Chemistry – A European Journal
SN - 0947-6539
TI - Hydrogenation of secondary amides using phosphane oxide and frustrated Lewis pair catalysis
ER -
TY - CHAP
AU - Schmidt, Jochen
ED - Roth, Michael
ED - Thums, Barbara
ED - Uhlig, Mirco
ID - 36953
KW - todsündenprojekt_vor_rüberkopieren
T2 - Ethnographien des Selbst
TI - Bekenne Dich selbst – bekenne Dir selbst: Sakralisierung des Selbst und Kritik
ER -
TY - JOUR
AU - Gurinov, Andrei
AU - Benedikt, Sieland
AU - Kuzhelev, Andrey
AU - Elgabarty, Hossam
AU - Kühne, Thomas D
AU - Prisner, Thomas
AU - Paradies, Jan
AU - Baldus, Marc
AU - Ivanov, Konstantin L
AU - Pylaeva, Svetlana
ID - 22231
JF - Angewandte Chemie International Edition
SN - 1433-7851
TI - Mixed‐valence compounds as polarizing agents for Overhauser dynamic nuclear polarization in solids
ER -
TY - GEN
AU - Schmidt, Jochen
ID - 36952
KW - hermeneuthik
KW - Ethik
T2 - ZEE
TI - Leben in Würde als Leben in Übereinstimmung mit sich selbst? Hermeneutisch-ethische Überlegungen im Anschluss an Würde als Haltung von Eva Weber-Guskar
VL - 65
ER -
TY - GEN
AU - Böttger, Meret Amalia Elisabeth
ID - 32402
TI - IND-CCA Secure PKE Schemes - Based on Lattices
ER -
TY - JOUR
AU - Schmidt, Jochen
ID - 38112
IS - 3-4
JF - International Journal for the Study of the Christian Church
KW - Religious studies
SN - 1474-225X
TI - Between church and state, confession and science on the position of theological faculties at German universities
VL - 21
ER -
TY - JOUR
AU - Schmidt, Jochen
ID - 36248
JF - ZEE
TI - Leben in Würde als Leben in Übereinstimmung mit sich selbst? Hermeneutisch-ethische Überlegungen im Anschluss an Würde als Haltung von Eva Weber-Guskar
ER -
TY - GEN
AU - Schmidt, Jochen
ID - 38113
TI - Rez. Olivia Mitscherlich-Schönherr (Hg.), Gelingendes Sterben. Zeitgenössische Theorien im interdisziplinären Dialog (Grenzgänge 1),
ER -
TY - JOUR
AB - The present paper investigates factors contributing to the home advantage, by using the exceptional opportunity to study professional football matches played in the absence of spectators due to the COVID-19 pandemic in 2020. More than 40,000 matches before and during the pandemic, including more than 1,000 professional matches without spectators across the main European football leagues, have been analyzed. Results support the notion of a crowd-induced referee bias as the increased sanctioning of away teams disappears in the absence of spectators with regard to fouls (p < .001), yellow cards (p < .001), and red cards (p < .05). Moreover, the match dominance of home teams decreases significantly as indicated by shots (p < .001) and shots on target (p < .01). In terms of the home advantage itself, surprisingly, only a non-significant decrease is found. While the present paper supports prior research with regard to a crowd-induced referee bias, spectators thus do not seem to be the main driving factor of the home advantage. Results from amateur football, being naturally played in absence of a crowd, provide further evidence that the home advantage is predominantly caused by factors not directly or indirectly attributable to a noteworthy number of spectators.
AU - Wunderlich, Fabian
AU - Weigelt, Matthias
AU - Rein, Robert
AU - Memmert, Daniel
ID - 37782
IS - 3
JF - PLOS ONE
KW - Multidisciplinary
SN - 1932-6203
TI - How does spectator presence affect football? Home advantage remains in European top-class football matches played without spectators during the COVID-19 pandemic
VL - 16
ER -
TY - JOUR
AB - BACKGROUND: Previous studies suggest better visual-spatial processing when participants are tested in postures in which dynamic stability is challenged. The question arises if this is also true for the performance in mental body-rotation tasks (MBRT).
AIM: Taking the embodied cognition approach into account, the first aim of the present study was to examine the potential influence of different demands on dynamic stability for two postures (parallel stand vs. tandem stand) on solving two versions of the MBRT, inducing either an object-based or an egocentric perspective transformation strategy. The second aim was to investigate if these different demands on dynamic stability are reflected in postural sway parameters.
METHOD: Thirty participants (18 females and 12 males) were tested in the two MBRTs and in a control condition. All tasks were performed while standing on a balance beam in tandem stand and in a feet parallel position on a force plate.
RESULTS: The results for response time and response error revealed effects of rotation angle and task, but no effect of posture. The analyzed Center of Pressure (CoP) data revealed a reduction of body sway during the MBRT for egocentric perspective transformations.
CONCLUSION: The results indicate that participants performed better for egocentric than for object-based transformations and that the egocentric transformation leads to more postural stability than the object-based.
AU - Budde, Kirsten
AU - Jöllenbeck, Thomas
AU - Barela, José A.
AU - Figueiredo, Gabriella A.
AU - Weigelt, Matthias
ID - 37772
IS - 3
JF - Brazilian Journal of Motor Behavior
KW - General Engineering
SN - 2446-4902
TI - Mental body rotation with egocentric and object-based transformations in different postures: standing vs. balancing
VL - 15
ER -