TY - JOUR AB - AbstractThe facile synthesis of highly functionalized building blocks with potential biological activity is of great interest to medicinal chemistry. The benzoxepinone core structures commonly exhibit biological activity. Thus, a short and efficient synthetic route towards benzoxepine containing scaffold, which enables late stage modification was developed. Namely, base-free catalytic Wittig reactions enabled the synthesis of bromobenzoxepinones from readily available starting materials. Subsequent, Suzuki–Miyaura and Stille reactions proved to be suitable methods to access a variety of benzoxepinone diaryl derivatives by late stage modification in only three steps. This three-step reaction sequence is suitable for high throughput applications and gives facile access to highly complex molecular structures, which are suitable for further functionalization. The antiproliferative properties of selected arylbenzoxepinones­ were tested in vitro on monolayer tumor cell line A549. Notably, in this initial screening, these compounds were found to be active in the micromolar range. AU - Werner, Thomas AU - Grandane, Aiga AU - Pudnika, Linda AU - Domraceva, Ilona AU - Zalubovskis, Raivis ID - 37946 IS - 19 JF - Synthesis KW - Organic Chemistry KW - Catalysis SN - 0039-7881 TI - Base-Free Catalytic Wittig-/Cross-Coupling Reaction Sequence as Short Synthetic Strategy for the Preparation of Highly Functionalized Arylbenzoxepinones VL - 53 ER - TY - JOUR AU - Paradies, Jan AU - Andexer, Jennifer AU - Beifuss, Uwe AU - Beuerle, Florian AU - Brasholz, Malte AU - Breinbauer, Rolf AU - Ernst, Martin AU - Ganardi, Ruth AU - Gulder, Tobias A. M. AU - Hüttel, Wolfgang AU - Kath‐Schorr, Stephanie AU - Körber, Karsten AU - Kordes, Markus AU - Lehmann, Matthias AU - Lindel, Thomas AU - Luy, Burkhard AU - Mück‐Lichtenfeld, Christian AU - Muhle‐Goll, Claudia AU - Niemeyer, Jochen AU - Pfau, Roland AU - Pietruszka, Jörg AU - Röckl, Johannes L. AU - Schaschke, Norbert AU - Senge, Mathias O. AU - Straub, Bernd F. AU - Waldvogel, Siegfried R. AU - Werner, Thomas AU - Werz, Daniel B. AU - Winter, Christian ID - 37947 IS - 3 JF - Nachrichten aus der Chemie KW - General Chemical Engineering KW - General Chemistry SN - 1439-9598 TI - Organische Chemie VL - 69 ER - TY - JOUR AB -

A Mn–PNP complex proved to be a suitable catalyst for the transfer hydrogenation of amides, carbamates, urea derivatives and even polyurethanes.

AU - Liu, Xin AU - Werner, Thomas ID - 37944 IS - 31 JF - Chemical Science KW - General Chemistry SN - 2041-6520 TI - Indirect reduction of CO2 and recycling of polymers by manganese-catalyzed transfer hydrogenation of amides, carbamates, urea derivatives, and polyurethanes VL - 12 ER - TY - JOUR AB -

PMHS proved to be a suitable terminal reductant for P(iii)/P(v) redox cycling with a methyl-substituted phosphetane as catalyst and BuOAc as solvent. The formation of water by silanol condensation was identified as main pathway of siloxane formation.

AU - Tönjes, Jan AU - Longwitz, Lars AU - Werner, Thomas ID - 37945 IS - 13 JF - Green Chemistry KW - Pollution KW - Environmental Chemistry SN - 1463-9262 TI - Poly(methylhydrosiloxane) as a reductant in the catalytic base-free Wittig reaction VL - 23 ER - TY - CONF AU - Dahm, Stephan AU - Weigelt, Matthias AU - Rieger, M. ID - 38080 TI - Representations after mentally practiced one finger sequences are effector independent ER - TY - JOUR AU - Wirth, Marisa A. AU - Longwitz, Lars AU - Kanwischer, Marion AU - Gros, Peter AU - Leinweber, Peter AU - Werner, Thomas ID - 37943 JF - Ecotoxicology and Environmental Safety KW - Health KW - Toxicology and Mutagenesis KW - Public Health KW - Environmental and Occupational Health KW - Pollution KW - General Medicine SN - 0147-6513 TI - AMPA-15N – Synthesis and application as standard compound in traceable degradation studies of glyphosate VL - 225 ER - TY - CONF AU - Budde, Kirsten AU - Barela, J.A. AU - Figueiredo, G.A. AU - Weigelt, Matthias ID - 38082 TI - Mental body rotation with egocentric and object-based transformations in different postures: sitting vs. standing ER - TY - JOUR AB - AbstractThe development of the frustrated Lewis pair catalyzed hydrogenation of tertiary and secondary amides is reviewed. Detailed insight into our strategies in order to overcome challenges during the reaction development process is provided. Furthermore, the developed chemistry is extended to the hydrogenation of polyamides and of trifluoroacetamides for the convenient introduction of trifluoroethyl groups into organic molecules. AU - Paradies, Jan AU - Köring, Laura AU - Sitte, Nikolai A. ID - 35686 IS - 05 JF - Synthesis KW - Organic Chemistry KW - Catalysis SN - 0039-7881 TI - Towards the Development of Frustrated Lewis Pair (FLP) Catalyzed Hydrogenations of Tertiary and Secondary Carboxylic Amides VL - 54 ER - TY - JOUR AU - Zhou, Rundong AU - Paradies, Jan ID - 35687 IS - 46 JF - European Journal of Organic Chemistry KW - Organic Chemistry KW - Physical and Theoretical Chemistry SN - 1434-193X TI - Borane Catalyzed Redox Isomerization of 2‐Amino Chalcones: Hydride Abstraction or Hydride Migration? VL - 2021 ER - TY - JOUR AU - Wicker, Garrit AU - Schoch, Roland AU - Paradies, Jan ID - 22232 JF - Organic Letters SN - 1523-7060 TI - Diastereoselective Synthesis of Dihydro-quinolin-4-ones by a Borane-Catalyzed Redox-Neutral endo-1,7-Hydride Shift ER - TY - JOUR AU - Köring, Laura AU - Sitte, Nikolai A. AU - Bursch, Markus AU - Grimme, Stefan AU - Paradies, Jan ID - 22233 JF - Chemistry – A European Journal SN - 0947-6539 TI - Hydrogenation of secondary amides using phosphane oxide and frustrated Lewis pair catalysis ER - TY - CHAP AU - Schmidt, Jochen ED - Roth, Michael ED - Thums, Barbara ED - Uhlig, Mirco ID - 36953 KW - todsündenprojekt_vor_rüberkopieren T2 - Ethnographien des Selbst TI - Bekenne Dich selbst – bekenne Dir selbst: Sakralisierung des Selbst und Kritik ER - TY - JOUR AU - Gurinov, Andrei AU - Benedikt, Sieland AU - Kuzhelev, Andrey AU - Elgabarty, Hossam AU - Kühne, Thomas D AU - Prisner, Thomas AU - Paradies, Jan AU - Baldus, Marc AU - Ivanov, Konstantin L AU - Pylaeva, Svetlana ID - 22231 JF - Angewandte Chemie International Edition SN - 1433-7851 TI - Mixed‐valence compounds as polarizing agents for Overhauser dynamic nuclear polarization in solids ER - TY - GEN AU - Schmidt, Jochen ID - 36952 KW - hermeneuthik KW - Ethik T2 - ZEE TI - Leben in Würde als Leben in Übereinstimmung mit sich selbst? Hermeneutisch-ethische Überlegungen im Anschluss an Würde als Haltung von Eva Weber-Guskar VL - 65 ER - TY - GEN AU - Böttger, Meret Amalia Elisabeth ID - 32402 TI - IND-CCA Secure PKE Schemes - Based on Lattices ER - TY - JOUR AU - Schmidt, Jochen ID - 38112 IS - 3-4 JF - International Journal for the Study of the Christian Church KW - Religious studies SN - 1474-225X TI - Between church and state, confession and science on the position of theological faculties at German universities VL - 21 ER - TY - JOUR AU - Schmidt, Jochen ID - 36248 JF - ZEE TI - Leben in Würde als Leben in Übereinstimmung mit sich selbst? Hermeneutisch-ethische Überlegungen im Anschluss an Würde als Haltung von Eva Weber-Guskar ER - TY - GEN AU - Schmidt, Jochen ID - 38113 TI - Rez. Olivia Mitscherlich-Schönherr (Hg.), Gelingendes Sterben. Zeitgenössische Theorien im interdisziplinären Dialog (Grenzgänge 1), ER - TY - JOUR AB - The present paper investigates factors contributing to the home advantage, by using the exceptional opportunity to study professional football matches played in the absence of spectators due to the COVID-19 pandemic in 2020. More than 40,000 matches before and during the pandemic, including more than 1,000 professional matches without spectators across the main European football leagues, have been analyzed. Results support the notion of a crowd-induced referee bias as the increased sanctioning of away teams disappears in the absence of spectators with regard to fouls (p < .001), yellow cards (p < .001), and red cards (p < .05). Moreover, the match dominance of home teams decreases significantly as indicated by shots (p < .001) and shots on target (p < .01). In terms of the home advantage itself, surprisingly, only a non-significant decrease is found. While the present paper supports prior research with regard to a crowd-induced referee bias, spectators thus do not seem to be the main driving factor of the home advantage. Results from amateur football, being naturally played in absence of a crowd, provide further evidence that the home advantage is predominantly caused by factors not directly or indirectly attributable to a noteworthy number of spectators. AU - Wunderlich, Fabian AU - Weigelt, Matthias AU - Rein, Robert AU - Memmert, Daniel ID - 37782 IS - 3 JF - PLOS ONE KW - Multidisciplinary SN - 1932-6203 TI - How does spectator presence affect football? Home advantage remains in European top-class football matches played without spectators during the COVID-19 pandemic VL - 16 ER - TY - JOUR AB - BACKGROUND: Previous studies suggest better visual-spatial processing when participants are tested in postures in which dynamic stability is challenged. The question arises if this is also true for the performance in mental body-rotation tasks (MBRT). AIM: Taking the embodied cognition approach into account, the first aim of the present study was to examine the potential influence of different demands on dynamic stability for two postures (parallel stand vs. tandem stand) on solving two versions of the MBRT, inducing either an object-based or an egocentric perspective transformation strategy. The second aim was to investigate if these different demands on dynamic stability are reflected in postural sway parameters. METHOD: Thirty participants (18 females and 12 males) were tested in the two MBRTs and in a control condition. All tasks were performed while standing on a balance beam in tandem stand and in a feet parallel position on a force plate. RESULTS: The results for response time and response error revealed effects of rotation angle and task, but no effect of posture. The analyzed Center of Pressure (CoP) data revealed a reduction of body sway during the MBRT for egocentric perspective transformations. CONCLUSION: The results indicate that participants performed better for egocentric than for object-based transformations and that the egocentric transformation leads to more postural stability than the object-based. AU - Budde, Kirsten AU - Jöllenbeck, Thomas AU - Barela, José A. AU - Figueiredo, Gabriella A. AU - Weigelt, Matthias ID - 37772 IS - 3 JF - Brazilian Journal of Motor Behavior KW - General Engineering SN - 2446-4902 TI - Mental body rotation with egocentric and object-based transformations in different postures: standing vs. balancing VL - 15 ER -