--- _id: '22926' abstract: - lang: eng text: Implant-associated infections are an increasingly severe burden on healthcare systems worldwide and many research activities currently focus on inhibiting microbial colonization of biomedically relevant surfaces. To obtain molecular-level understanding of the involved processes and interactions, we investigate the adsorption of synthetic adhesin-like peptide sequences derived from the type IV pili of the Pseudomonas aeruginosa strains PAK and PAO at abiotic model surfaces, i.e., Au, SiO2, and oxidized Ti. These peptides correspond to the sequences of the receptor-binding domain 128–144 of the major pilin protein, which is known to facilitate P. aeruginosa adhesion at biotic and abiotic surfaces. Using quartz crystal microbalance with dissipation monitoring (QCM-D), we find that peptide adsorption is material- as well as strain-dependent. At the Au surface, PAO(128–144) shows drastically stronger adsorption than PAK(128–144), whereas adsorption of both peptides is markedly reduced at the oxide surfaces with less drastic differences between the two sequences. These observations suggest that peptide adsorption is influenced by not only the peptide sequence, but also peptide conformation. Our results furthermore highlight the importance of molecular-level investigations to understand and ultimately control microbial colonization of surfaces. author: - first_name: Yu full_name: Yang, Yu last_name: Yang - first_name: Sabrina full_name: Schwiderek, Sabrina last_name: Schwiderek - first_name: Guido full_name: Grundmeier, Guido id: '194' last_name: Grundmeier - first_name: Adrian full_name: Keller, Adrian id: '48864' last_name: Keller orcid: 0000-0001-7139-3110 citation: ama: Yang Y, Schwiderek S, Grundmeier G, Keller A. Strain-Dependent Adsorption of Pseudomonas aeruginosa-Derived Adhesin-like Peptides at Abiotic Surfaces. Micro. 2021;1(1):129-139. doi:10.3390/micro1010010 apa: Yang, Y., Schwiderek, S., Grundmeier, G., & Keller, A. (2021). Strain-Dependent Adsorption of Pseudomonas aeruginosa-Derived Adhesin-like Peptides at Abiotic Surfaces. Micro, 1(1), 129–139. https://doi.org/10.3390/micro1010010 bibtex: '@article{Yang_Schwiderek_Grundmeier_Keller_2021, title={Strain-Dependent Adsorption of Pseudomonas aeruginosa-Derived Adhesin-like Peptides at Abiotic Surfaces}, volume={1}, DOI={10.3390/micro1010010}, number={1}, journal={Micro}, author={Yang, Yu and Schwiderek, Sabrina and Grundmeier, Guido and Keller, Adrian}, year={2021}, pages={129–139} }' chicago: 'Yang, Yu, Sabrina Schwiderek, Guido Grundmeier, and Adrian Keller. “Strain-Dependent Adsorption of Pseudomonas Aeruginosa-Derived Adhesin-like Peptides at Abiotic Surfaces.” Micro 1, no. 1 (2021): 129–39. https://doi.org/10.3390/micro1010010.' ieee: Y. Yang, S. Schwiderek, G. Grundmeier, and A. Keller, “Strain-Dependent Adsorption of Pseudomonas aeruginosa-Derived Adhesin-like Peptides at Abiotic Surfaces,” Micro, vol. 1, no. 1, pp. 129–139, 2021. mla: Yang, Yu, et al. “Strain-Dependent Adsorption of Pseudomonas Aeruginosa-Derived Adhesin-like Peptides at Abiotic Surfaces.” Micro, vol. 1, no. 1, 2021, pp. 129–39, doi:10.3390/micro1010010. short: Y. Yang, S. Schwiderek, G. Grundmeier, A. Keller, Micro 1 (2021) 129–139. date_created: 2021-08-03T06:07:33Z date_updated: 2022-01-06T06:55:43Z department: - _id: '302' doi: 10.3390/micro1010010 intvolume: ' 1' issue: '1' language: - iso: eng page: 129-139 publication: Micro publication_identifier: issn: - 2673-8023 publication_status: published status: public title: Strain-Dependent Adsorption of Pseudomonas aeruginosa-Derived Adhesin-like Peptides at Abiotic Surfaces type: journal_article user_id: '48864' volume: 1 year: '2021' ...