---
_id: '22926'
abstract:
- lang: eng
text: Implant-associated infections are an increasingly severe burden on
healthcare systems worldwide and many research activities currently focus on inhibiting
microbial colonization of biomedically relevant surfaces. To obtain molecular-level
understanding of the involved processes and interactions, we investigate the adsorption
of synthetic adhesin-like peptide sequences derived from the type IV pili of the
Pseudomonas aeruginosa strains PAK and PAO at abiotic model surfaces, i.e., Au,
SiO2, and oxidized Ti. These peptides correspond to the sequences of the receptor-binding
domain 128–144 of the major pilin protein, which is known to facilitate P. aeruginosa
adhesion at biotic and abiotic surfaces. Using quartz crystal microbalance with
dissipation monitoring (QCM-D), we find that peptide adsorption is material- as
well as strain-dependent. At the Au surface, PAO(128–144) shows drastically stronger
adsorption than PAK(128–144), whereas adsorption of both peptides is markedly
reduced at the oxide surfaces with less drastic differences between the two sequences.
These observations suggest that peptide adsorption is influenced by not only the
peptide sequence, but also peptide conformation. Our results furthermore highlight
the importance of molecular-level investigations to understand and ultimately
control microbial colonization of surfaces.
author:
- first_name: Yu
full_name: Yang, Yu
last_name: Yang
- first_name: Sabrina
full_name: Schwiderek, Sabrina
last_name: Schwiderek
- first_name: Guido
full_name: Grundmeier, Guido
id: '194'
last_name: Grundmeier
- first_name: Adrian
full_name: Keller, Adrian
id: '48864'
last_name: Keller
orcid: 0000-0001-7139-3110
citation:
ama: Yang Y, Schwiderek S, Grundmeier G, Keller A. Strain-Dependent Adsorption of
Pseudomonas aeruginosa-Derived Adhesin-like Peptides at Abiotic Surfaces. Micro.
2021;1(1):129-139. doi:10.3390/micro1010010
apa: Yang, Y., Schwiderek, S., Grundmeier, G., & Keller, A. (2021). Strain-Dependent
Adsorption of Pseudomonas aeruginosa-Derived Adhesin-like Peptides at Abiotic
Surfaces. Micro, 1(1), 129–139. https://doi.org/10.3390/micro1010010
bibtex: '@article{Yang_Schwiderek_Grundmeier_Keller_2021, title={Strain-Dependent
Adsorption of Pseudomonas aeruginosa-Derived Adhesin-like Peptides at Abiotic
Surfaces}, volume={1}, DOI={10.3390/micro1010010},
number={1}, journal={Micro}, author={Yang, Yu and Schwiderek, Sabrina and Grundmeier,
Guido and Keller, Adrian}, year={2021}, pages={129–139} }'
chicago: 'Yang, Yu, Sabrina Schwiderek, Guido Grundmeier, and Adrian Keller. “Strain-Dependent
Adsorption of Pseudomonas Aeruginosa-Derived Adhesin-like Peptides at Abiotic
Surfaces.” Micro 1, no. 1 (2021): 129–39. https://doi.org/10.3390/micro1010010.'
ieee: Y. Yang, S. Schwiderek, G. Grundmeier, and A. Keller, “Strain-Dependent Adsorption
of Pseudomonas aeruginosa-Derived Adhesin-like Peptides at Abiotic Surfaces,”
Micro, vol. 1, no. 1, pp. 129–139, 2021.
mla: Yang, Yu, et al. “Strain-Dependent Adsorption of Pseudomonas Aeruginosa-Derived
Adhesin-like Peptides at Abiotic Surfaces.” Micro, vol. 1, no. 1, 2021,
pp. 129–39, doi:10.3390/micro1010010.
short: Y. Yang, S. Schwiderek, G. Grundmeier, A. Keller, Micro 1 (2021) 129–139.
date_created: 2021-08-03T06:07:33Z
date_updated: 2022-01-06T06:55:43Z
department:
- _id: '302'
doi: 10.3390/micro1010010
intvolume: ' 1'
issue: '1'
language:
- iso: eng
page: 129-139
publication: Micro
publication_identifier:
issn:
- 2673-8023
publication_status: published
status: public
title: Strain-Dependent Adsorption of Pseudomonas aeruginosa-Derived Adhesin-like
Peptides at Abiotic Surfaces
type: journal_article
user_id: '48864'
volume: 1
year: '2021'
...