Suggestive Evidence for Causal Effect of Leptin Levels on Risk for Anorexia Nervosa: Results of a Mendelian Randomization Study

T. Peters, J. Antel, R. Naaresh, B.-H. Laabs, M. Föcker, N. Albers, J. Bühlmeier, A. Hinney, L. Libuda, J. Hebebrand, Frontiers in Genetics (2021).

Download
No fulltext has been uploaded.
Journal Article | Published | English
Author
; ; ; ; ; ; ; ; ;
Abstract
<jats:p>Genetic correlations suggest a coexisting genetic predisposition to both low leptin levels and risk for anorexia nervosa (AN). To investigate the causality and direction of these associations, we performed bidirectional two-sample Mendelian randomization (MR) analyses using data of the most recent genome-wide association study (GWAS) for AN and both a GWAS and an exome-wide-association-study (EWAS) for leptin levels. Most MR methods with genetic instruments from GWAS showed a causal effect of lower leptin levels on higher risk of AN (e.g. IVW b = −0.923, <jats:italic>p</jats:italic> = 1.5 × 10<jats:sup>−4</jats:sup>). Because most patients with AN are female, we additionally performed analyses using leptin GWAS data of females only. Again, there was a significant effect of leptin levels on the risk of AN (e.g. IVW b = −0.826, <jats:italic>p</jats:italic> = 1.1 × 10<jats:sup>−04</jats:sup>). MR with genetic instruments from EWAS showed no overall effect of leptin levels on the risk for AN. For the opposite direction, MR revealed no causal effect of AN on leptin levels. If our results are confirmed in extended GWAS data sets, a low endogenous leptin synthesis represents a risk factor for developing AN.</jats:p>
Publishing Year
Journal Title
Frontiers in Genetics
ISSN
LibreCat-ID

Cite this

Peters T, Antel J, Naaresh R, et al. Suggestive Evidence for Causal Effect of Leptin Levels on Risk for Anorexia Nervosa: Results of a Mendelian Randomization Study. Frontiers in Genetics. Published online 2021. doi:10.3389/fgene.2021.733606
Peters, T., Antel, J., Naaresh, R., Laabs, B.-H., Föcker, M., Albers, N., Bühlmeier, J., Hinney, A., Libuda, L., & Hebebrand, J. (2021). Suggestive Evidence for Causal Effect of Leptin Levels on Risk for Anorexia Nervosa: Results of a Mendelian Randomization Study. Frontiers in Genetics. https://doi.org/10.3389/fgene.2021.733606
@article{Peters_Antel_Naaresh_Laabs_Föcker_Albers_Bühlmeier_Hinney_Libuda_Hebebrand_2021, title={Suggestive Evidence for Causal Effect of Leptin Levels on Risk for Anorexia Nervosa: Results of a Mendelian Randomization Study}, DOI={10.3389/fgene.2021.733606}, journal={Frontiers in Genetics}, author={Peters, Triinu and Antel, Jochen and Naaresh, Roaa and Laabs, Björn-Hergen and Föcker, Manuel and Albers, Nicola and Bühlmeier, Judith and Hinney, Anke and Libuda, Lars and Hebebrand, Johannes}, year={2021} }
Peters, Triinu, Jochen Antel, Roaa Naaresh, Björn-Hergen Laabs, Manuel Föcker, Nicola Albers, Judith Bühlmeier, Anke Hinney, Lars Libuda, and Johannes Hebebrand. “Suggestive Evidence for Causal Effect of Leptin Levels on Risk for Anorexia Nervosa: Results of a Mendelian Randomization Study.” Frontiers in Genetics, 2021. https://doi.org/10.3389/fgene.2021.733606.
T. Peters et al., “Suggestive Evidence for Causal Effect of Leptin Levels on Risk for Anorexia Nervosa: Results of a Mendelian Randomization Study,” Frontiers in Genetics, 2021, doi: 10.3389/fgene.2021.733606.
Peters, Triinu, et al. “Suggestive Evidence for Causal Effect of Leptin Levels on Risk for Anorexia Nervosa: Results of a Mendelian Randomization Study.” Frontiers in Genetics, 2021, doi:10.3389/fgene.2021.733606.

Export

Marked Publications

Open Data LibreCat

Search this title in

Google Scholar