{"doi":"10.1038/s41598-020-80693-4","_id":"26632","abstract":[{"lang":"eng","text":"<jats:title>Abstract</jats:title><jats:p>Anorexia nervosa (AN) is a severe eating disorder and often associated with altered humoral immune responses. However, distinct B cell maturation stages in peripheral blood in adolescents with AN have not been characterized. Treatment effects and the relationship between clinical and B cell parameters are also not fully understood. Here we investigated the phenotype of circulating B cell subsets and the relationship with body composition in adolescents with AN before (T0, n = 24) and after 6 weeks (T1, n = 20) of treatment. Using multi-parameter flow cytometry, we found increased percentages of antigen-experienced B cells and plasmablasts in patients with AN compared to healthy controls (n = 20). In contrast, percentages of CD1d<jats:sup>+</jats:sup>CD5<jats:sup>+</jats:sup> B cells and transitional B cells with immunoregulatory roles were reduced at T0 and T1. These B cell frequencies correlated positively with fat mass, fat mass index (FMI), free fat mass index, and body mass index standard deviation score. In addition, scavenger-like receptor CD5 expression levels were downregulated on transitional B cells and correlated with fat mass and FMI in AN. Our findings that regulatory B cell subgroups were reduced in AN and their strong relationship with body composition parameters point toward an impact of immunoregulatory B cells in the pathogenesis of AN.</jats:p>"}],"user_id":"89838","title":"Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa","department":[{"_id":"35"},{"_id":"22"},{"_id":"395"}],"author":[{"first_name":"Jana","full_name":"Freff, Jana","last_name":"Freff"},{"last_name":"Schwarte","full_name":"Schwarte, Kathrin","first_name":"Kathrin"},{"first_name":"Lisa","full_name":"Bröker, Lisa","last_name":"Bröker"},{"full_name":"Bühlmeier, Judith","last_name":"Bühlmeier","first_name":"Judith","id":"89838"},{"first_name":"Isabelle","last_name":"Kraft","full_name":"Kraft, Isabelle"},{"last_name":"Öztürk","full_name":"Öztürk, Dana","first_name":"Dana"},{"last_name":"Hinney","full_name":"Hinney, Anke","first_name":"Anke"},{"first_name":"Volker","full_name":"Arolt, Volker","last_name":"Arolt"},{"first_name":"Udo","full_name":"Dannlowski, Udo","last_name":"Dannlowski"},{"first_name":"Georg","last_name":"Romer","full_name":"Romer, Georg"},{"last_name":"Baune","full_name":"Baune, Bernhard T.","first_name":"Bernhard T."},{"full_name":"Hebebrand, Johannes","last_name":"Hebebrand","first_name":"Johannes"},{"full_name":"Föcker, Manuel","last_name":"Föcker","first_name":"Manuel"},{"first_name":"Judith","full_name":"Alferink, Judith","last_name":"Alferink"}],"type":"journal_article","publication":"Scientific Reports","date_created":"2021-10-20T18:56:17Z","publication_identifier":{"issn":["2045-2322"]},"citation":{"mla":"Freff, Jana, et al. “Alterations in B Cell Subsets Correlate with Body Composition Parameters in Female Adolescents with Anorexia Nervosa.” <i>Scientific Reports</i>, 2021, doi:<a href=\"https://doi.org/10.1038/s41598-020-80693-4\">10.1038/s41598-020-80693-4</a>.","chicago":"Freff, Jana, Kathrin Schwarte, Lisa Bröker, Judith Bühlmeier, Isabelle Kraft, Dana Öztürk, Anke Hinney, et al. “Alterations in B Cell Subsets Correlate with Body Composition Parameters in Female Adolescents with Anorexia Nervosa.” <i>Scientific Reports</i>, 2021. <a href=\"https://doi.org/10.1038/s41598-020-80693-4\">https://doi.org/10.1038/s41598-020-80693-4</a>.","ieee":"J. Freff <i>et al.</i>, “Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa,” <i>Scientific Reports</i>, 2021, doi: <a href=\"https://doi.org/10.1038/s41598-020-80693-4\">10.1038/s41598-020-80693-4</a>.","bibtex":"@article{Freff_Schwarte_Bröker_Bühlmeier_Kraft_Öztürk_Hinney_Arolt_Dannlowski_Romer_et al._2021, title={Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa}, DOI={<a href=\"https://doi.org/10.1038/s41598-020-80693-4\">10.1038/s41598-020-80693-4</a>}, journal={Scientific Reports}, author={Freff, Jana and Schwarte, Kathrin and Bröker, Lisa and Bühlmeier, Judith and Kraft, Isabelle and Öztürk, Dana and Hinney, Anke and Arolt, Volker and Dannlowski, Udo and Romer, Georg and et al.}, year={2021} }","apa":"Freff, J., Schwarte, K., Bröker, L., Bühlmeier, J., Kraft, I., Öztürk, D., Hinney, A., Arolt, V., Dannlowski, U., Romer, G., Baune, B. T., Hebebrand, J., Föcker, M., &#38; Alferink, J. (2021). Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa. <i>Scientific Reports</i>. <a href=\"https://doi.org/10.1038/s41598-020-80693-4\">https://doi.org/10.1038/s41598-020-80693-4</a>","ama":"Freff J, Schwarte K, Bröker L, et al. Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa. <i>Scientific Reports</i>. Published online 2021. doi:<a href=\"https://doi.org/10.1038/s41598-020-80693-4\">10.1038/s41598-020-80693-4</a>","short":"J. Freff, K. Schwarte, L. Bröker, J. Bühlmeier, I. Kraft, D. Öztürk, A. Hinney, V. Arolt, U. Dannlowski, G. Romer, B.T. Baune, J. Hebebrand, M. Föcker, J. Alferink, Scientific Reports (2021)."},"year":"2021","date_updated":"2022-09-15T09:50:35Z","extern":"1","publication_status":"published","status":"public","language":[{"iso":"eng"}]}