{"language":[{"iso":"eng"}],"publication_status":"published","doi":"10.1093/ajcn/nqz273","publication":"The American Journal of Clinical Nutrition","type":"journal_article","date_updated":"2022-01-06T06:57:32Z","status":"public","year":"2019","author":[{"first_name":"Lukas","full_name":"Schwingshackl, Lukas","last_name":"Schwingshackl"},{"first_name":"Manuela","full_name":"Neuenschwander, Manuela","last_name":"Neuenschwander"},{"full_name":"Hoffmann, Georg","last_name":"Hoffmann","first_name":"Georg"},{"last_name":"Buyken","id":"65985","full_name":"Buyken, Anette","first_name":"Anette"},{"full_name":"Schlesinger, Sabrina","last_name":"Schlesinger","first_name":"Sabrina"}],"abstract":[{"lang":"eng","text":"<jats:title>ABSTRACT</jats:title>\r\n               <jats:sec>\r\n                  <jats:title>Background</jats:title>\r\n                  <jats:p>There is controversy on the relevance of dietary sugar intake for cardiometabolic health.</jats:p>\r\n               </jats:sec>\r\n               <jats:sec>\r\n                  <jats:title>Objective</jats:title>\r\n                  <jats:p>The aim of this network meta-analysis (NMA) was to assess how isocaloric substitutions of dietary sugar with other carbohydrates affect cardiometabolic risk factors, comparing different intervention studies.</jats:p>\r\n               </jats:sec>\r\n               <jats:sec>\r\n                  <jats:title>Methods</jats:title>\r\n                  <jats:p>We included randomized controlled trials (RCTs) investigating the isocaloric effect of substituting dietary sugars (fructose, glucose, sucrose) with other sugars or starch on cardiometabolic risk markers, including LDL cholesterol, triacylglycerol (TG), fasting glucose (FG), glycated hemoglobin (HbA1c), insulin resistance (HOMA-IR), uric acid, C-reactive protein (CRP), alanine transaminase (ALT), aspartate transaminase (AST), and liver fat content. To identify the most beneficial intervention for each outcome, random-effects NMA was conducted by calculating pooled mean differences (MDs) with 95% CIs, and by ranking the surface under the cumulative ranking curves (SUCRAs). The certainty of evidence was evaluated using the Confidence In Network Meta-Analysis tool.</jats:p>\r\n               </jats:sec>\r\n               <jats:sec>\r\n                  <jats:title>Results</jats:title>\r\n                  <jats:p>Thirty-eight RCTs, including 1383 participants, were identified. A reduction in LDL-cholesterol concentrations was shown for the exchange of sucrose with starch (MD: −0.23 mmol/L; 95% CI: −0.38, −0.07 mmol/L) or fructose with starch (MD: −0.22 mmol/L; 95% CI: −0.39, −0.05 mmol/L; SUCRAstarch: 98%). FG concentrations were also lower for the exchange of sucrose with starch (MD: −0.14 mmol/L; 95% CI: −0.29, 0.01 mmol/L; SUCRAstarch: 91%). Replacing fructose with an equivalent energy amount of glucose reduced HOMA-IR (MD: −0.36; 95% CI: −0.71, −0.02; SUCRAglucose: 74%) and uric acid (MD: −23.77 µmol/L; 95% CI: −44.21, −3.32 µmol/L; SUCRAglucose: 93%). The certainty of evidence was rated very low to moderate. No significant effects were observed for TG, HbA1c, CRP, ALT, and AST.</jats:p>\r\n               </jats:sec>\r\n               <jats:sec>\r\n                  <jats:title>Conclusions</jats:title>\r\n                  <jats:p>Our findings indicate that substitution of sucrose and fructose with starch yielded lower LDL cholesterol. Insulin resistance and uric acid concentrations were beneficially affected by replacement of fructose with glucose. Our findings are limited by the very low to moderate certainty of evidence. This review was registered at www.crd.york.ac.uk/prospero as CRD42018080297.</jats:p>\r\n               </jats:sec>"}],"publication_identifier":{"issn":["0002-9165","1938-3207"]},"department":[{"_id":"17"},{"_id":"22"},{"_id":"571"}],"_id":"27005","title":"Dietary sugars and cardiometabolic risk factors: a network meta-analysis on isocaloric substitution interventions","citation":{"bibtex":"@article{Schwingshackl_Neuenschwander_Hoffmann_Buyken_Schlesinger_2019, title={Dietary sugars and cardiometabolic risk factors: a network meta-analysis on isocaloric substitution interventions}, DOI={<a href=\"https://doi.org/10.1093/ajcn/nqz273\">10.1093/ajcn/nqz273</a>}, journal={The American Journal of Clinical Nutrition}, author={Schwingshackl, Lukas and Neuenschwander, Manuela and Hoffmann, Georg and Buyken, Anette and Schlesinger, Sabrina}, year={2019} }","short":"L. Schwingshackl, M. Neuenschwander, G. Hoffmann, A. Buyken, S. Schlesinger, The American Journal of Clinical Nutrition (2019).","chicago":"Schwingshackl, Lukas, Manuela Neuenschwander, Georg Hoffmann, Anette Buyken, and Sabrina Schlesinger. “Dietary Sugars and Cardiometabolic Risk Factors: A Network Meta-Analysis on Isocaloric Substitution Interventions.” <i>The American Journal of Clinical Nutrition</i>, 2019. <a href=\"https://doi.org/10.1093/ajcn/nqz273\">https://doi.org/10.1093/ajcn/nqz273</a>.","ieee":"L. Schwingshackl, M. Neuenschwander, G. Hoffmann, A. Buyken, and S. Schlesinger, “Dietary sugars and cardiometabolic risk factors: a network meta-analysis on isocaloric substitution interventions,” <i>The American Journal of Clinical Nutrition</i>, 2019, doi: <a href=\"https://doi.org/10.1093/ajcn/nqz273\">10.1093/ajcn/nqz273</a>.","mla":"Schwingshackl, Lukas, et al. “Dietary Sugars and Cardiometabolic Risk Factors: A Network Meta-Analysis on Isocaloric Substitution Interventions.” <i>The American Journal of Clinical Nutrition</i>, 2019, doi:<a href=\"https://doi.org/10.1093/ajcn/nqz273\">10.1093/ajcn/nqz273</a>.","ama":"Schwingshackl L, Neuenschwander M, Hoffmann G, Buyken A, Schlesinger S. Dietary sugars and cardiometabolic risk factors: a network meta-analysis on isocaloric substitution interventions. <i>The American Journal of Clinical Nutrition</i>. Published online 2019. doi:<a href=\"https://doi.org/10.1093/ajcn/nqz273\">10.1093/ajcn/nqz273</a>","apa":"Schwingshackl, L., Neuenschwander, M., Hoffmann, G., Buyken, A., &#38; Schlesinger, S. (2019). Dietary sugars and cardiometabolic risk factors: a network meta-analysis on isocaloric substitution interventions. <i>The American Journal of Clinical Nutrition</i>. <a href=\"https://doi.org/10.1093/ajcn/nqz273\">https://doi.org/10.1093/ajcn/nqz273</a>"},"user_id":"61597","date_created":"2021-10-29T13:45:47Z"}