{"language":[{"iso":"eng"}],"publication_status":"published","doi":"10.1007/s00394-020-02463-2","page":"3029-3041","publication":"European Journal of Nutrition","type":"journal_article","date_updated":"2022-01-06T06:57:32Z","status":"public","year":"2021","abstract":[{"lang":"eng","text":"<jats:title>Abstract</jats:title><jats:sec>\r\n                <jats:title>Purpose</jats:title>\r\n                <jats:p>To examine the association between fructose intake in adolescence and fatty liver indices (hepatic steatosis index (HSI), fatty liver index (FLI)) in young adulthood.</jats:p>\r\n              </jats:sec><jats:sec>\r\n                <jats:title>Methods</jats:title>\r\n                <jats:p>Overall, 246 participants of the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study who had a fasting blood sample in adulthood (18–36 years), at least two 3-day weighed dietary records for calculating fructose intakes and other fructose-containing sugars (total (TS), free (FS), added sugar (AS)) as well as two complete 24-h urine samples for calculating sugar excretion (fructose excretion (FE), fructose + sucrose excretion (FE + SE)) in adolescence (males: 9.5–16.5 years; females: 8.5–15.5 years) were analysed using multivariable linear regression analyses.</jats:p>\r\n              </jats:sec><jats:sec>\r\n                <jats:title>Results</jats:title>\r\n                <jats:p>On the level of dietary intake, no prospective associations were observed between adolescent fructose intake and both adult fatty liver indices, whereas higher FS intakes were associated with lower levels of HSI (<jats:italic>P</jats:italic><jats:sub>trend</jats:sub> = 0.02) and FLI (<jats:italic>P</jats:italic><jats:sub>trend</jats:sub> = 0.03). On the urinary excretion level, however, a higher FE (P<jats:sub>trend</jats:sub> = 0.03) and FE + SE (<jats:italic>P</jats:italic><jats:sub>trend</jats:sub> = 0.01) in adolescence were prospectively related to higher adult FLI values. No associations were observed between adolescent sugar excretion and adult HSI.</jats:p>\r\n              </jats:sec><jats:sec>\r\n                <jats:title>Conclusion</jats:title>\r\n                <jats:p>The present study does not provide unambiguous support for a detrimental impact of adolescent fructose intake on adult liver health. Nonetheless, further examinations estimating exposure by means of urinary excretion as well as dietary intake levels appear warranted.</jats:p>\r\n              </jats:sec>"}],"author":[{"last_name":"Perrar","full_name":"Perrar, Ines","first_name":"Ines"},{"first_name":"Anette","full_name":"Buyken, Anette","id":"65985","last_name":"Buyken"},{"first_name":"Katharina J.","last_name":"Penczynski","full_name":"Penczynski, Katharina J."},{"first_name":"Thomas","last_name":"Remer","full_name":"Remer, Thomas"},{"first_name":"Gunter G.","last_name":"Kuhnle","full_name":"Kuhnle, Gunter G."},{"first_name":"Christian","full_name":"Herder, Christian","last_name":"Herder"},{"first_name":"Michael","full_name":"Roden, Michael","last_name":"Roden"},{"first_name":"Karen","last_name":"Della Corte","full_name":"Della Corte, Karen"},{"full_name":"Nöthlings, Ute","last_name":"Nöthlings","first_name":"Ute"},{"first_name":"Ute","full_name":"Alexy, Ute","last_name":"Alexy"}],"publication_identifier":{"issn":["1436-6207","1436-6215"]},"department":[{"_id":"17"},{"_id":"22"},{"_id":"571"}],"_id":"27007","title":"Relevance of fructose intake in adolescence for fatty liver indices in young adulthood","citation":{"ama":"Perrar I, Buyken A, Penczynski KJ, et al. Relevance of fructose intake in adolescence for fatty liver indices in young adulthood. <i>European Journal of Nutrition</i>. Published online 2021:3029-3041. doi:<a href=\"https://doi.org/10.1007/s00394-020-02463-2\">10.1007/s00394-020-02463-2</a>","mla":"Perrar, Ines, et al. “Relevance of Fructose Intake in Adolescence for Fatty Liver Indices in Young Adulthood.” <i>European Journal of Nutrition</i>, 2021, pp. 3029–41, doi:<a href=\"https://doi.org/10.1007/s00394-020-02463-2\">10.1007/s00394-020-02463-2</a>.","bibtex":"@article{Perrar_Buyken_Penczynski_Remer_Kuhnle_Herder_Roden_Della Corte_Nöthlings_Alexy_2021, title={Relevance of fructose intake in adolescence for fatty liver indices in young adulthood}, DOI={<a href=\"https://doi.org/10.1007/s00394-020-02463-2\">10.1007/s00394-020-02463-2</a>}, journal={European Journal of Nutrition}, author={Perrar, Ines and Buyken, Anette and Penczynski, Katharina J. and Remer, Thomas and Kuhnle, Gunter G. and Herder, Christian and Roden, Michael and Della Corte, Karen and Nöthlings, Ute and Alexy, Ute}, year={2021}, pages={3029–3041} }","ieee":"I. Perrar <i>et al.</i>, “Relevance of fructose intake in adolescence for fatty liver indices in young adulthood,” <i>European Journal of Nutrition</i>, pp. 3029–3041, 2021, doi: <a href=\"https://doi.org/10.1007/s00394-020-02463-2\">10.1007/s00394-020-02463-2</a>.","chicago":"Perrar, Ines, Anette Buyken, Katharina J. Penczynski, Thomas Remer, Gunter G. Kuhnle, Christian Herder, Michael Roden, Karen Della Corte, Ute Nöthlings, and Ute Alexy. “Relevance of Fructose Intake in Adolescence for Fatty Liver Indices in Young Adulthood.” <i>European Journal of Nutrition</i>, 2021, 3029–41. <a href=\"https://doi.org/10.1007/s00394-020-02463-2\">https://doi.org/10.1007/s00394-020-02463-2</a>.","short":"I. Perrar, A. Buyken, K.J. Penczynski, T. Remer, G.G. Kuhnle, C. Herder, M. Roden, K. Della Corte, U. Nöthlings, U. Alexy, European Journal of Nutrition (2021) 3029–3041.","apa":"Perrar, I., Buyken, A., Penczynski, K. J., Remer, T., Kuhnle, G. G., Herder, C., Roden, M., Della Corte, K., Nöthlings, U., &#38; Alexy, U. (2021). Relevance of fructose intake in adolescence for fatty liver indices in young adulthood. <i>European Journal of Nutrition</i>, 3029–3041. <a href=\"https://doi.org/10.1007/s00394-020-02463-2\">https://doi.org/10.1007/s00394-020-02463-2</a>"},"user_id":"61597","date_created":"2021-10-29T13:48:27Z"}