{"date_created":"2021-11-01T19:11:56Z","user_id":"89838","citation":{"ama":"Libuda L, Timmesfeld N, Antel J, et al. Effect of vitamin D deficiency on depressive symptoms in child and adolescent psychiatric patients: results of a randomized controlled trial. <i>European Journal of Nutrition</i>. Published online 2020:3415-3424. doi:<a href=\"https://doi.org/10.1007/s00394-020-02176-6\">10.1007/s00394-020-02176-6</a>","bibtex":"@article{Libuda_Timmesfeld_Antel_Hirtz_Bauer_Führer_Zwanziger_Öztürk_Langenbach_Hahn_et al._2020, title={Effect of vitamin D deficiency on depressive symptoms in child and adolescent psychiatric patients: results of a randomized controlled trial}, DOI={<a href=\"https://doi.org/10.1007/s00394-020-02176-6\">10.1007/s00394-020-02176-6</a>}, journal={European Journal of Nutrition}, author={Libuda, Lars and Timmesfeld, Nina and Antel, Jochen and Hirtz, Raphael and Bauer, Jens and Führer, Dagmar and Zwanziger, Denise and Öztürk, Dana and Langenbach, Gina and Hahn, Denise and et al.}, year={2020}, pages={3415–3424} }","mla":"Libuda, Lars, et al. “Effect of Vitamin D Deficiency on Depressive Symptoms in Child and Adolescent Psychiatric Patients: Results of a Randomized Controlled Trial.” <i>European Journal of Nutrition</i>, 2020, pp. 3415–24, doi:<a href=\"https://doi.org/10.1007/s00394-020-02176-6\">10.1007/s00394-020-02176-6</a>.","ieee":"L. Libuda <i>et al.</i>, “Effect of vitamin D deficiency on depressive symptoms in child and adolescent psychiatric patients: results of a randomized controlled trial,” <i>European Journal of Nutrition</i>, pp. 3415–3424, 2020, doi: <a href=\"https://doi.org/10.1007/s00394-020-02176-6\">10.1007/s00394-020-02176-6</a>.","chicago":"Libuda, Lars, Nina Timmesfeld, Jochen Antel, Raphael Hirtz, Jens Bauer, Dagmar Führer, Denise Zwanziger, et al. “Effect of Vitamin D Deficiency on Depressive Symptoms in Child and Adolescent Psychiatric Patients: Results of a Randomized Controlled Trial.” <i>European Journal of Nutrition</i>, 2020, 3415–24. <a href=\"https://doi.org/10.1007/s00394-020-02176-6\">https://doi.org/10.1007/s00394-020-02176-6</a>.","short":"L. Libuda, N. Timmesfeld, J. Antel, R. Hirtz, J. Bauer, D. Führer, D. Zwanziger, D. Öztürk, G. Langenbach, D. Hahn, S. Ring, T. Peters, A. Hinney, J. Bühlmeier, J. Hebebrand, C. Grasemann, M. Föcker, European Journal of Nutrition (2020) 3415–3424.","apa":"Libuda, L., Timmesfeld, N., Antel, J., Hirtz, R., Bauer, J., Führer, D., Zwanziger, D., Öztürk, D., Langenbach, G., Hahn, D., Ring, S., Peters, T., Hinney, A., Bühlmeier, J., Hebebrand, J., Grasemann, C., &#38; Föcker, M. (2020). Effect of vitamin D deficiency on depressive symptoms in child and adolescent psychiatric patients: results of a randomized controlled trial. <i>European Journal of Nutrition</i>, 3415–3424. <a href=\"https://doi.org/10.1007/s00394-020-02176-6\">https://doi.org/10.1007/s00394-020-02176-6</a>"},"_id":"27022","title":"Effect of vitamin D deficiency on depressive symptoms in child and adolescent psychiatric patients: results of a randomized controlled trial","department":[{"_id":"35"},{"_id":"22"},{"_id":"395"}],"publication_identifier":{"issn":["1436-6207","1436-6215"]},"author":[{"first_name":"Lars","orcid":"0000-0003-1603-3133","id":"88682","last_name":"Libuda","full_name":"Libuda, Lars"},{"last_name":"Timmesfeld","full_name":"Timmesfeld, Nina","first_name":"Nina"},{"first_name":"Jochen","full_name":"Antel, Jochen","last_name":"Antel"},{"full_name":"Hirtz, Raphael","last_name":"Hirtz","first_name":"Raphael"},{"last_name":"Bauer","full_name":"Bauer, Jens","first_name":"Jens"},{"first_name":"Dagmar","last_name":"Führer","full_name":"Führer, Dagmar"},{"first_name":"Denise","last_name":"Zwanziger","full_name":"Zwanziger, Denise"},{"full_name":"Öztürk, Dana","last_name":"Öztürk","first_name":"Dana"},{"full_name":"Langenbach, Gina","last_name":"Langenbach","first_name":"Gina"},{"first_name":"Denise","last_name":"Hahn","full_name":"Hahn, Denise"},{"first_name":"Stefanie","last_name":"Ring","full_name":"Ring, Stefanie"},{"full_name":"Peters, Triinu","last_name":"Peters","first_name":"Triinu"},{"first_name":"Anke","full_name":"Hinney, Anke","last_name":"Hinney"},{"full_name":"Bühlmeier, Judith","last_name":"Bühlmeier","id":"89838","first_name":"Judith"},{"first_name":"Johannes","last_name":"Hebebrand","full_name":"Hebebrand, Johannes"},{"first_name":"Corinna","last_name":"Grasemann","full_name":"Grasemann, Corinna"},{"last_name":"Föcker","full_name":"Föcker, Manuel","first_name":"Manuel"}],"abstract":[{"lang":"eng","text":"<jats:title>Abstract</jats:title><jats:sec>\r\n<jats:title>Purpose</jats:title>\r\n<jats:p>While observational studies revealed inverse associations between serum vitamin D levels [25(OH)D] and depression, randomized controlled trials (RCT) in children and adolescents are lacking. This RCT examined the effect of an untreated vitamin D deficiency compared to an immediate vitamin D<jats:sub>3</jats:sub> supplementation on depression scores in children and adolescents during standard day and in-patient psychiatric treatment.</jats:p>\r\n</jats:sec><jats:sec>\r\n<jats:title>Methods</jats:title>\r\n<jats:p>Patients with vitamin D deficiency [25(OH)D ≤ 30 nmol/l] and at least mild depression [Beck Depression Inventory II (BDI-II) &gt; 13] (<jats:italic>n</jats:italic> = 113) were 1:1 randomized into verum (VG; 2640 IU vitamin D<jats:sub>3</jats:sub>/d) or placebo group (PG) in a double-blind manner. During the intervention period of 28 days, both groups additionally received treatment as usual. BDI-II scores were assessed as primary outcome, DISYPS-II (Diagnostic System for Mental Disorders in Childhood and Adolescence, Self- and Parent Rating) and serum total 25(OH)D were secondary outcomes.</jats:p>\r\n</jats:sec><jats:sec>\r\n<jats:title>Results</jats:title>\r\n<jats:p>At admission, 49.3% of the screened patients (<jats:italic>n</jats:italic> = 280) had vitamin D deficiency. Although the intervention led to a higher increase of 25(OH)D levels in the VG than in the PG (treatment difference: + 14 ng/ml; 95% CI 4.86–23.77; <jats:italic>p</jats:italic> = 0.003), the change in BDI-II scores did not differ (+ 1.3; 95% CI − 2.22 to 4.81; <jats:italic>p</jats:italic> = 0.466). In contrast, DISYPS parental ratings revealed pronounced improvements of depressive symptoms in the VG (− 0.68; 95% CI − 1.23 to − 0.13; <jats:italic>p</jats:italic> = 0.016).</jats:p>\r\n</jats:sec><jats:sec>\r\n<jats:title>Conclusion</jats:title>\r\n<jats:p>Whereas this study failed to show a vitamin D supplementation effect on self-rated depression in adolescent in- or daycare patients, parents reported less depressive symptoms in VG at the end of our study. Future trials should consider clinician-rated depressive symptoms as primary outcome.</jats:p>\r\n</jats:sec><jats:sec>\r\n<jats:title>Trial registration</jats:title>\r\n<jats:p>“German Clinical Trials Register” (<jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"uri\" xlink:href=\"https://www.drks.de\">https://www.drks.de</jats:ext-link>), registration number: DRKS00009758</jats:p>\r\n</jats:sec>"}],"extern":"1","year":"2020","status":"public","type":"journal_article","date_updated":"2022-09-15T09:49:57Z","publication":"European Journal of Nutrition","page":"3415-3424","doi":"10.1007/s00394-020-02176-6","publication_status":"published","language":[{"iso":"eng"}]}