{"publication_status":"published","language":[{"iso":"eng"}],"publication":"Nutrients","date_updated":"2022-09-15T09:50:10Z","type":"journal_article","doi":"10.3390/nu11051085","article_number":"1085","author":[{"id":"88682","last_name":"Libuda","full_name":"Libuda, Lars","orcid":"0000-0003-1603-3133","first_name":"Lars"},{"full_name":"Laabs, Björn-Hergen","last_name":"Laabs","first_name":"Björn-Hergen"},{"first_name":"Christine","full_name":"Ludwig, Christine","last_name":"Ludwig"},{"first_name":"Judith","last_name":"Bühlmeier","id":"89838","full_name":"Bühlmeier, Judith"},{"first_name":"Jochen","last_name":"Antel","full_name":"Antel, Jochen"},{"first_name":"Anke","last_name":"Hinney","full_name":"Hinney, Anke"},{"last_name":"Naaresh","full_name":"Naaresh, Roaa","first_name":"Roaa"},{"last_name":"Föcker","full_name":"Föcker, Manuel","first_name":"Manuel"},{"first_name":"Johannes","last_name":"Hebebrand","full_name":"Hebebrand, Johannes"},{"first_name":"Inke R.","last_name":"König","full_name":"König, Inke R."},{"first_name":"Triinu","last_name":"Peters","full_name":"Peters, Triinu"}],"abstract":[{"text":"<jats:p>While observational studies show an association between 25(OH)vitamin D concentrations and depressive symptoms, intervention studies, which examine the preventive effects of vitamin D supplementation on the development of depression, are lacking. To estimate the role of lowered 25(OH)vitamin D concentrations in the etiology of depressive disorders, we conducted a two-sample Mendelian randomization (MR) study on depression, i.e., “depressive symptoms” (DS, n = 161,460) and “broad depression” (BD, n = 113,769 cases and 208,811 controls). Six single nucleotide polymorphisms (SNPs), which were genome-wide significantly associated with 25(OH)vitamin D concentrations in 79,366 subjects from the SUNLIGHT genome-wide association study (GWAS), were used as an instrumental variable. None of the six SNPs was associated with DS or BD (all p &gt; 0.05). MR analysis revealed no causal effects of 25(OH)vitamin D concentration, either on DS (inverse variance weighted (IVW); b = 0.025, SE = 0.038, p = 0.52) or on BD (IVW; b = 0.020, SE = 0.012, p = 0.10). Sensitivity analyses confirmed that 25(OH)vitamin D concentrations were not significantly associated with DS or BD. The findings from this MR study indicate no causal relationship between vitamin D concentrations and depressive symptoms, or broad depression. Conflicting findings from observational studies might have resulted from residual confounding or reverse causation.</jats:p>","lang":"eng"}],"extern":"1","year":"2019","status":"public","date_created":"2021-11-01T19:27:13Z","citation":{"mla":"Libuda, Lars, et al. “Vitamin D and the Risk of Depression: A Causal Relationship? Findings from a Mendelian Randomization Study.” <i>Nutrients</i>, 1085, 2019, doi:<a href=\"https://doi.org/10.3390/nu11051085\">10.3390/nu11051085</a>.","ama":"Libuda L, Laabs B-H, Ludwig C, et al. Vitamin D and the Risk of Depression: A Causal Relationship? Findings from a Mendelian Randomization Study. <i>Nutrients</i>. Published online 2019. doi:<a href=\"https://doi.org/10.3390/nu11051085\">10.3390/nu11051085</a>","ieee":"L. Libuda <i>et al.</i>, “Vitamin D and the Risk of Depression: A Causal Relationship? Findings from a Mendelian Randomization Study,” <i>Nutrients</i>, Art. no. 1085, 2019, doi: <a href=\"https://doi.org/10.3390/nu11051085\">10.3390/nu11051085</a>.","apa":"Libuda, L., Laabs, B.-H., Ludwig, C., Bühlmeier, J., Antel, J., Hinney, A., Naaresh, R., Föcker, M., Hebebrand, J., König, I. R., &#38; Peters, T. (2019). Vitamin D and the Risk of Depression: A Causal Relationship? Findings from a Mendelian Randomization Study. <i>Nutrients</i>, Article 1085. <a href=\"https://doi.org/10.3390/nu11051085\">https://doi.org/10.3390/nu11051085</a>","bibtex":"@article{Libuda_Laabs_Ludwig_Bühlmeier_Antel_Hinney_Naaresh_Föcker_Hebebrand_König_et al._2019, title={Vitamin D and the Risk of Depression: A Causal Relationship? Findings from a Mendelian Randomization Study}, DOI={<a href=\"https://doi.org/10.3390/nu11051085\">10.3390/nu11051085</a>}, number={1085}, journal={Nutrients}, author={Libuda, Lars and Laabs, Björn-Hergen and Ludwig, Christine and Bühlmeier, Judith and Antel, Jochen and Hinney, Anke and Naaresh, Roaa and Föcker, Manuel and Hebebrand, Johannes and König, Inke R. and et al.}, year={2019} }","chicago":"Libuda, Lars, Björn-Hergen Laabs, Christine Ludwig, Judith Bühlmeier, Jochen Antel, Anke Hinney, Roaa Naaresh, et al. “Vitamin D and the Risk of Depression: A Causal Relationship? Findings from a Mendelian Randomization Study.” <i>Nutrients</i>, 2019. <a href=\"https://doi.org/10.3390/nu11051085\">https://doi.org/10.3390/nu11051085</a>.","short":"L. Libuda, B.-H. Laabs, C. Ludwig, J. Bühlmeier, J. Antel, A. Hinney, R. Naaresh, M. Föcker, J. Hebebrand, I.R. König, T. Peters, Nutrients (2019)."},"user_id":"89838","department":[{"_id":"35"},{"_id":"22"},{"_id":"395"}],"publication_identifier":{"issn":["2072-6643"]},"title":"Vitamin D and the Risk of Depression: A Causal Relationship? Findings from a Mendelian Randomization Study","_id":"27026"}