{"abstract":[{"text":"<jats:sec>\r\n                  <jats:title>Context:</jats:title>\r\n                  <jats:p>Whether prepubertal glucocorticoid status impacts on the timing of puberty is not clear.</jats:p>\r\n               </jats:sec>\r\n               <jats:sec>\r\n                  <jats:title>Objective:</jats:title>\r\n                  <jats:p>The objective of the study was to examine the relationship between prepubertal glucocorticoid status and early or late pubertal markers, independent of adrenarchal and nutritional status.</jats:p>\r\n               </jats:sec>\r\n               <jats:sec>\r\n                  <jats:title>Design and Participants:</jats:title>\r\n                  <jats:p>Prospective cohort study of healthy Caucasian children (n = 111, 56 boys) who provided both 24-h urine samples and weighed dietary records 1 and 2 yr before the start of pubertal growth spurt [age at take-off (ATO)].</jats:p>\r\n               </jats:sec>\r\n               <jats:sec>\r\n                  <jats:title>Measurements:</jats:title>\r\n                  <jats:p>Major urinary glucocorticoid and androgen metabolites determined by gas chromatography-mass spectrometry analysis were summed to assess daily overall cortisol (ΣC21) and adrenal androgen secretion; urinary free cortisol and cortisone measured by RIA were summed (UFF+UFE) as an indicator of potentially bioactive free glucocorticoids.</jats:p>\r\n               </jats:sec>\r\n               <jats:sec>\r\n                  <jats:title>Main Outcomes:</jats:title>\r\n                  <jats:p>The main outcomes included ATO, age at peak height velocity, age at menarche/voice break, ages at Tanner stage 2 for breast (girls) and genital (boys) development, and pubic hair.</jats:p>\r\n               </jats:sec>\r\n               <jats:sec>\r\n                  <jats:title>Results:</jats:title>\r\n                  <jats:p>In girls ΣC21, but not UFF+UFE, was associated with pubertal markers after adjusting for overall adrenal androgen, urinary nitrogen, and body fat. Girls with higher ΣC21 (fourth quartile) reached ATO 0.7 yr (P = 0.01) and menarche 0.9 yr later (P = 0.006) than girls with lower ΣC21 (first quartile). The ΣC21 tended to be also positively associated with age at Tanner stage 2 for breast (P = 0.1), Tanner stage 2 for pubic hair (P = 0.1), and age at peak height velocity (P = 0.06). In boys, neither the ΣC21 nor UFF+UFE was related to pubertal timing.</jats:p>\r\n               </jats:sec>\r\n               <jats:sec>\r\n                  <jats:title>Conclusion:</jats:title>\r\n                  <jats:p>An individually higher prepubertal glucocorticoid secretion level, even in physiological range, appears to delay early and late pubertal timing of healthy girls, particularly their onset of pubertal growth spurt and menarche.</jats:p>\r\n               </jats:sec>","lang":"eng"}],"doi":"10.1210/jc.2010-2935","department":[{"_id":"17"},{"_id":"22"},{"_id":"571"}],"user_id":"61597","citation":{"chicago":"Shi, Lijie, Stefan A. Wudy, Anette Buyken, Christiane Maser-Gluth, Michaela F. Hartmann, and Thomas Remer. “Prepubertal Glucocorticoid Status and Pubertal Timing.” <i>The Journal of Clinical Endocrinology &#38; Metabolism</i>, 2011, E891–98. <a href=\"https://doi.org/10.1210/jc.2010-2935\">https://doi.org/10.1210/jc.2010-2935</a>.","bibtex":"@article{Shi_Wudy_Buyken_Maser-Gluth_Hartmann_Remer_2011, title={Prepubertal Glucocorticoid Status and Pubertal Timing}, DOI={<a href=\"https://doi.org/10.1210/jc.2010-2935\">10.1210/jc.2010-2935</a>}, journal={The Journal of Clinical Endocrinology &#38; Metabolism}, author={Shi, Lijie and Wudy, Stefan A. and Buyken, Anette and Maser-Gluth, Christiane and Hartmann, Michaela F. and Remer, Thomas}, year={2011}, pages={E891–E898} }","ama":"Shi L, Wudy SA, Buyken A, Maser-Gluth C, Hartmann MF, Remer T. Prepubertal Glucocorticoid Status and Pubertal Timing. <i>The Journal of Clinical Endocrinology &#38; Metabolism</i>. Published online 2011:E891-E898. doi:<a href=\"https://doi.org/10.1210/jc.2010-2935\">10.1210/jc.2010-2935</a>","short":"L. Shi, S.A. Wudy, A. Buyken, C. Maser-Gluth, M.F. Hartmann, T. Remer, The Journal of Clinical Endocrinology &#38; Metabolism (2011) E891–E898.","ieee":"L. Shi, S. A. Wudy, A. Buyken, C. Maser-Gluth, M. F. Hartmann, and T. Remer, “Prepubertal Glucocorticoid Status and Pubertal Timing,” <i>The Journal of Clinical Endocrinology &#38; Metabolism</i>, pp. E891–E898, 2011, doi: <a href=\"https://doi.org/10.1210/jc.2010-2935\">10.1210/jc.2010-2935</a>.","apa":"Shi, L., Wudy, S. A., Buyken, A., Maser-Gluth, C., Hartmann, M. F., &#38; Remer, T. (2011). Prepubertal Glucocorticoid Status and Pubertal Timing. <i>The Journal of Clinical Endocrinology &#38; Metabolism</i>, E891–E898. <a href=\"https://doi.org/10.1210/jc.2010-2935\">https://doi.org/10.1210/jc.2010-2935</a>","mla":"Shi, Lijie, et al. “Prepubertal Glucocorticoid Status and Pubertal Timing.” <i>The Journal of Clinical Endocrinology &#38; Metabolism</i>, 2011, pp. E891–98, doi:<a href=\"https://doi.org/10.1210/jc.2010-2935\">10.1210/jc.2010-2935</a>."},"type":"journal_article","page":"E891-E898","date_created":"2021-11-23T15:53:56Z","title":"Prepubertal Glucocorticoid Status and Pubertal Timing","publication":"The Journal of Clinical Endocrinology & Metabolism","author":[{"last_name":"Shi","full_name":"Shi, Lijie","first_name":"Lijie"},{"first_name":"Stefan A.","last_name":"Wudy","full_name":"Wudy, Stefan A."},{"first_name":"Anette","id":"65985","last_name":"Buyken","full_name":"Buyken, Anette"},{"last_name":"Maser-Gluth","full_name":"Maser-Gluth, Christiane","first_name":"Christiane"},{"first_name":"Michaela F.","last_name":"Hartmann","full_name":"Hartmann, Michaela F."},{"last_name":"Remer","full_name":"Remer, Thomas","first_name":"Thomas"}],"status":"public","date_updated":"2022-01-06T06:57:44Z","publication_status":"published","year":"2011","_id":"27728","publication_identifier":{"issn":["0021-972X","1945-7197"]},"language":[{"iso":"eng"}]}