---
_id: '27728'
abstract:
- lang: eng
text: "\r\n Context:\r\n Whether
prepubertal glucocorticoid status impacts on the timing of puberty is not clear.\r\n
\ \r\n \r\n Objective:\r\n
\ The objective of the study was to examine the relationship
between prepubertal glucocorticoid status and early or late pubertal markers,
independent of adrenarchal and nutritional status.\r\n \r\n
\ \r\n Design and Participants:\r\n
\ Prospective cohort study of healthy Caucasian children
(n = 111, 56 boys) who provided both 24-h urine samples and weighed dietary records
1 and 2 yr before the start of pubertal growth spurt [age at take-off (ATO)].\r\n
\ \r\n \r\n Measurements:\r\n
\ Major urinary glucocorticoid and androgen metabolites
determined by gas chromatography-mass spectrometry analysis were summed to assess
daily overall cortisol (ΣC21) and adrenal androgen secretion; urinary free cortisol
and cortisone measured by RIA were summed (UFF+UFE) as an indicator of potentially
bioactive free glucocorticoids.\r\n \r\n \r\n
\ Main Outcomes:\r\n The
main outcomes included ATO, age at peak height velocity, age at menarche/voice
break, ages at Tanner stage 2 for breast (girls) and genital (boys) development,
and pubic hair.\r\n \r\n \r\n
\ Results:\r\n In
girls ΣC21, but not UFF+UFE, was associated with pubertal markers after adjusting
for overall adrenal androgen, urinary nitrogen, and body fat. Girls with higher
ΣC21 (fourth quartile) reached ATO 0.7 yr (P = 0.01) and menarche 0.9 yr later
(P = 0.006) than girls with lower ΣC21 (first quartile). The ΣC21 tended to be
also positively associated with age at Tanner stage 2 for breast (P = 0.1), Tanner
stage 2 for pubic hair (P = 0.1), and age at peak height velocity (P = 0.06).
In boys, neither the ΣC21 nor UFF+UFE was related to pubertal timing.\r\n
\ \r\n \r\n Conclusion:\r\n
\ An individually higher prepubertal glucocorticoid secretion
level, even in physiological range, appears to delay early and late pubertal timing
of healthy girls, particularly their onset of pubertal growth spurt and menarche.\r\n
\ "
author:
- first_name: Lijie
full_name: Shi, Lijie
last_name: Shi
- first_name: Stefan A.
full_name: Wudy, Stefan A.
last_name: Wudy
- first_name: Anette
full_name: Buyken, Anette
id: '65985'
last_name: Buyken
- first_name: Christiane
full_name: Maser-Gluth, Christiane
last_name: Maser-Gluth
- first_name: Michaela F.
full_name: Hartmann, Michaela F.
last_name: Hartmann
- first_name: Thomas
full_name: Remer, Thomas
last_name: Remer
citation:
ama: Shi L, Wudy SA, Buyken A, Maser-Gluth C, Hartmann MF, Remer T. Prepubertal
Glucocorticoid Status and Pubertal Timing. The Journal of Clinical Endocrinology
& Metabolism. Published online 2011:E891-E898. doi:10.1210/jc.2010-2935
apa: Shi, L., Wudy, S. A., Buyken, A., Maser-Gluth, C., Hartmann, M. F., & Remer,
T. (2011). Prepubertal Glucocorticoid Status and Pubertal Timing. The Journal
of Clinical Endocrinology & Metabolism, E891–E898. https://doi.org/10.1210/jc.2010-2935
bibtex: '@article{Shi_Wudy_Buyken_Maser-Gluth_Hartmann_Remer_2011, title={Prepubertal
Glucocorticoid Status and Pubertal Timing}, DOI={10.1210/jc.2010-2935},
journal={The Journal of Clinical Endocrinology & Metabolism}, author={Shi,
Lijie and Wudy, Stefan A. and Buyken, Anette and Maser-Gluth, Christiane and Hartmann,
Michaela F. and Remer, Thomas}, year={2011}, pages={E891–E898} }'
chicago: Shi, Lijie, Stefan A. Wudy, Anette Buyken, Christiane Maser-Gluth, Michaela
F. Hartmann, and Thomas Remer. “Prepubertal Glucocorticoid Status and Pubertal
Timing.” The Journal of Clinical Endocrinology & Metabolism, 2011,
E891–98. https://doi.org/10.1210/jc.2010-2935.
ieee: 'L. Shi, S. A. Wudy, A. Buyken, C. Maser-Gluth, M. F. Hartmann, and T. Remer,
“Prepubertal Glucocorticoid Status and Pubertal Timing,” The Journal of Clinical
Endocrinology & Metabolism, pp. E891–E898, 2011, doi: 10.1210/jc.2010-2935.'
mla: Shi, Lijie, et al. “Prepubertal Glucocorticoid Status and Pubertal Timing.”
The Journal of Clinical Endocrinology & Metabolism, 2011, pp. E891–98,
doi:10.1210/jc.2010-2935.
short: L. Shi, S.A. Wudy, A. Buyken, C. Maser-Gluth, M.F. Hartmann, T. Remer, The
Journal of Clinical Endocrinology & Metabolism (2011) E891–E898.
date_created: 2021-11-23T15:53:56Z
date_updated: 2022-01-06T06:57:44Z
department:
- _id: '17'
- _id: '22'
- _id: '571'
doi: 10.1210/jc.2010-2935
language:
- iso: eng
page: E891-E898
publication: The Journal of Clinical Endocrinology & Metabolism
publication_identifier:
issn:
- 0021-972X
- 1945-7197
publication_status: published
status: public
title: Prepubertal Glucocorticoid Status and Pubertal Timing
type: journal_article
user_id: '61597'
year: '2011'
...