--- _id: '27728' abstract: - lang: eng text: "\r\n Context:\r\n Whether prepubertal glucocorticoid status impacts on the timing of puberty is not clear.\r\n \ \r\n \r\n Objective:\r\n \ The objective of the study was to examine the relationship between prepubertal glucocorticoid status and early or late pubertal markers, independent of adrenarchal and nutritional status.\r\n \r\n \ \r\n Design and Participants:\r\n \ Prospective cohort study of healthy Caucasian children (n = 111, 56 boys) who provided both 24-h urine samples and weighed dietary records 1 and 2 yr before the start of pubertal growth spurt [age at take-off (ATO)].\r\n \ \r\n \r\n Measurements:\r\n \ Major urinary glucocorticoid and androgen metabolites determined by gas chromatography-mass spectrometry analysis were summed to assess daily overall cortisol (ΣC21) and adrenal androgen secretion; urinary free cortisol and cortisone measured by RIA were summed (UFF+UFE) as an indicator of potentially bioactive free glucocorticoids.\r\n \r\n \r\n \ Main Outcomes:\r\n The main outcomes included ATO, age at peak height velocity, age at menarche/voice break, ages at Tanner stage 2 for breast (girls) and genital (boys) development, and pubic hair.\r\n \r\n \r\n \ Results:\r\n In girls ΣC21, but not UFF+UFE, was associated with pubertal markers after adjusting for overall adrenal androgen, urinary nitrogen, and body fat. Girls with higher ΣC21 (fourth quartile) reached ATO 0.7 yr (P = 0.01) and menarche 0.9 yr later (P = 0.006) than girls with lower ΣC21 (first quartile). The ΣC21 tended to be also positively associated with age at Tanner stage 2 for breast (P = 0.1), Tanner stage 2 for pubic hair (P = 0.1), and age at peak height velocity (P = 0.06). In boys, neither the ΣC21 nor UFF+UFE was related to pubertal timing.\r\n \ \r\n \r\n Conclusion:\r\n \ An individually higher prepubertal glucocorticoid secretion level, even in physiological range, appears to delay early and late pubertal timing of healthy girls, particularly their onset of pubertal growth spurt and menarche.\r\n \ " author: - first_name: Lijie full_name: Shi, Lijie last_name: Shi - first_name: Stefan A. full_name: Wudy, Stefan A. last_name: Wudy - first_name: Anette full_name: Buyken, Anette id: '65985' last_name: Buyken - first_name: Christiane full_name: Maser-Gluth, Christiane last_name: Maser-Gluth - first_name: Michaela F. full_name: Hartmann, Michaela F. last_name: Hartmann - first_name: Thomas full_name: Remer, Thomas last_name: Remer citation: ama: Shi L, Wudy SA, Buyken A, Maser-Gluth C, Hartmann MF, Remer T. Prepubertal Glucocorticoid Status and Pubertal Timing. The Journal of Clinical Endocrinology & Metabolism. Published online 2011:E891-E898. doi:10.1210/jc.2010-2935 apa: Shi, L., Wudy, S. A., Buyken, A., Maser-Gluth, C., Hartmann, M. F., & Remer, T. (2011). Prepubertal Glucocorticoid Status and Pubertal Timing. The Journal of Clinical Endocrinology & Metabolism, E891–E898. https://doi.org/10.1210/jc.2010-2935 bibtex: '@article{Shi_Wudy_Buyken_Maser-Gluth_Hartmann_Remer_2011, title={Prepubertal Glucocorticoid Status and Pubertal Timing}, DOI={10.1210/jc.2010-2935}, journal={The Journal of Clinical Endocrinology & Metabolism}, author={Shi, Lijie and Wudy, Stefan A. and Buyken, Anette and Maser-Gluth, Christiane and Hartmann, Michaela F. and Remer, Thomas}, year={2011}, pages={E891–E898} }' chicago: Shi, Lijie, Stefan A. Wudy, Anette Buyken, Christiane Maser-Gluth, Michaela F. Hartmann, and Thomas Remer. “Prepubertal Glucocorticoid Status and Pubertal Timing.” The Journal of Clinical Endocrinology & Metabolism, 2011, E891–98. https://doi.org/10.1210/jc.2010-2935. ieee: 'L. Shi, S. A. Wudy, A. Buyken, C. Maser-Gluth, M. F. Hartmann, and T. Remer, “Prepubertal Glucocorticoid Status and Pubertal Timing,” The Journal of Clinical Endocrinology & Metabolism, pp. E891–E898, 2011, doi: 10.1210/jc.2010-2935.' mla: Shi, Lijie, et al. “Prepubertal Glucocorticoid Status and Pubertal Timing.” The Journal of Clinical Endocrinology & Metabolism, 2011, pp. E891–98, doi:10.1210/jc.2010-2935. short: L. Shi, S.A. Wudy, A. Buyken, C. Maser-Gluth, M.F. Hartmann, T. Remer, The Journal of Clinical Endocrinology & Metabolism (2011) E891–E898. date_created: 2021-11-23T15:53:56Z date_updated: 2022-01-06T06:57:44Z department: - _id: '17' - _id: '22' - _id: '571' doi: 10.1210/jc.2010-2935 language: - iso: eng page: E891-E898 publication: The Journal of Clinical Endocrinology & Metabolism publication_identifier: issn: - 0021-972X - 1945-7197 publication_status: published status: public title: Prepubertal Glucocorticoid Status and Pubertal Timing type: journal_article user_id: '61597' year: '2011' ...