---
_id: '30119'
abstract:
- lang: eng
text: "Abstract\r\n Background\r\n
\ Subjective Memory Complaints (SMC) in elderly people due
to preclinical Alzheimer’s Disease may be associated with dysregulation of the
Kynurenine Pathway (KP), with an increase in neurotoxic metabolites that affect
cognition. Golf is a challenging sport with high demands on motor, sensory, and
cognitive abilities, which might bear the potential to attenuate the pathological
changes of preclinical AD. This trial investigated the feasibility of learning
to play golf for elderly with cognitive problems and its effects on cognitive
functions and the KP.\r\n \r\n Methods\r\n
\ In a 22-week single-blinded randomized controlled trial,
elderly people with SMC were allocated to the golf (n = 25,
180 min training/week) or control group (n = 21). Primary
outcomes were feasibility (golf exam, adherence, adverse events) and general cognitive
function (Alzheimer’s Disease Assessment Scale). Secondary outcomes include specific
cognitive functions (Response Inhibition, Corsi Block Tapping Test, Trail Making
Test), KP metabolites and physical performance (6-Minute-Walk-Test). Baseline-adjusted
Analysis-of-Covariance was conducted for each outcome.\r\n \r\n
\ Results\r\n 42
participants were analyzed. All participants that underwent the golf exam after
the intervention passed it (20/23). Attendance rate of the golf intervention was
75 %. No adverse events or drop-outs related to the intervention occurred. A significant
time*group interaction (p = 0.012, F = 7.050, Cohen’s
d = 0.89) was found for correct responses on the Response Inhibition task, but
not for ADAS-Cog. Moreover, a significant time*group interaction for Quinolinic
acid to Tryptophan ratios (p = 0.022, F = 5.769, Cohen’s
d = 0.84) in favor of the golf group was observed. An uncorrected negative correlation
between attendance rate and delta Quinolinic acid to Kynurenic acid ratios in
the golf group (p = 0.039, r=-0.443)
was found as well.\r\n \r\n Conclusions\r\n
\ The findings indicate that learning golf is feasible and
safe for elderly people with cognitive problems. Preliminary results suggest positive
effects on attention and the KP. To explore the whole potential of golfing and
its effect on cognitive decline, a larger cohort should be studied over a longer
period with higher cardiovascular demands.\r\n \r\n
\ Trial registration\r\n The
trial was retrospectively registered (2nd July 2018) at the German Clinical Trials
Register (DRKS00014921).\r\n
\ "
article_number: '200'
author:
- first_name: Julia K.
full_name: Stroehlein, Julia K.
last_name: Stroehlein
- first_name: Solveig
full_name: Vieluf, Solveig
last_name: Vieluf
- first_name: Philipp
full_name: Zimmer, Philipp
last_name: Zimmer
- first_name: Alexander
full_name: Schenk, Alexander
last_name: Schenk
- first_name: Max
full_name: Oberste, Max
last_name: Oberste
- first_name: Christian Johannes
full_name: Gölz, Christian Johannes
id: '33725'
last_name: Gölz
orcid: 0000-0003-0536-1481
- first_name: Franziska
full_name: van den Bongard, Franziska
last_name: van den Bongard
- first_name: Claus
full_name: Reinsberger, Claus
id: '48978'
last_name: Reinsberger
citation:
ama: 'Stroehlein JK, Vieluf S, Zimmer P, et al. Learning to play golf for elderly
people with subjective memory complaints: feasibility of a single‐blinded randomized
pilot trial. BMC Neurology. 2021;21(1). doi:10.1186/s12883-021-02186-9'
apa: 'Stroehlein, J. K., Vieluf, S., Zimmer, P., Schenk, A., Oberste, M., Gölz,
C. J., van den Bongard, F., & Reinsberger, C. (2021). Learning to play golf
for elderly people with subjective memory complaints: feasibility of a single‐blinded
randomized pilot trial. BMC Neurology, 21(1), Article 200. https://doi.org/10.1186/s12883-021-02186-9'
bibtex: '@article{Stroehlein_Vieluf_Zimmer_Schenk_Oberste_Gölz_van den Bongard_Reinsberger_2021,
title={Learning to play golf for elderly people with subjective memory complaints:
feasibility of a single‐blinded randomized pilot trial}, volume={21}, DOI={10.1186/s12883-021-02186-9},
number={1200}, journal={BMC Neurology}, publisher={Springer Science and Business
Media LLC}, author={Stroehlein, Julia K. and Vieluf, Solveig and Zimmer, Philipp
and Schenk, Alexander and Oberste, Max and Gölz, Christian Johannes and van den
Bongard, Franziska and Reinsberger, Claus}, year={2021} }'
chicago: 'Stroehlein, Julia K., Solveig Vieluf, Philipp Zimmer, Alexander Schenk,
Max Oberste, Christian Johannes Gölz, Franziska van den Bongard, and Claus Reinsberger.
“Learning to Play Golf for Elderly People with Subjective Memory Complaints: Feasibility
of a Single‐blinded Randomized Pilot Trial.” BMC Neurology 21, no. 1 (2021).
https://doi.org/10.1186/s12883-021-02186-9.'
ieee: 'J. K. Stroehlein et al., “Learning to play golf for elderly people
with subjective memory complaints: feasibility of a single‐blinded randomized
pilot trial,” BMC Neurology, vol. 21, no. 1, Art. no. 200, 2021, doi: 10.1186/s12883-021-02186-9.'
mla: 'Stroehlein, Julia K., et al. “Learning to Play Golf for Elderly People with
Subjective Memory Complaints: Feasibility of a Single‐blinded Randomized Pilot
Trial.” BMC Neurology, vol. 21, no. 1, 200, Springer Science and Business
Media LLC, 2021, doi:10.1186/s12883-021-02186-9.'
short: J.K. Stroehlein, S. Vieluf, P. Zimmer, A. Schenk, M. Oberste, C.J. Gölz,
F. van den Bongard, C. Reinsberger, BMC Neurology 21 (2021).
date_created: 2022-02-25T12:02:57Z
date_updated: 2023-02-06T09:30:38Z
department:
- _id: '35'
- _id: '17'
- _id: '176'
doi: 10.1186/s12883-021-02186-9
intvolume: ' 21'
issue: '1'
keyword:
- Clinical Neurology
- General Medicine
language:
- iso: eng
publication: BMC Neurology
publication_identifier:
issn:
- 1471-2377
publication_status: published
publisher: Springer Science and Business Media LLC
status: public
title: 'Learning to play golf for elderly people with subjective memory complaints:
feasibility of a single‐blinded randomized pilot trial'
type: journal_article
user_id: '33213'
volume: 21
year: '2021'
...